Javier Oltra, Annegret Habich, Christopher G Schwarz, Zuzana Nedelska, Scott A Przybelski, Anna Inguanzo, Patricia Diaz-Galvan, Val J Lowe, Ketil Oppedal, Maria C Gonzalez, Nathalie Philippi, Frederic Blanc, Frederik Barkhof, Afina W Lemstra, Jakub Hort, Alessandro Padovani, Irena Rektorova, Laura Bonanni, Federico Massa, Milica G Kramberger, John-Paul Taylor, Jon G Snaedal, Zuzana Walker, Angelo Antonini, Thomas Dierks, Barbara Segura, Carme Junque, Eric Westman, Bradley F Boeve, Dag Aarsland, Kejal Kantarci, Daniel Ferreira
INTRODUCTION: Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI). METHODS: We included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 ± 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 ± 9 years, 72% males)...
December 22, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association