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https://www.readbyqxmd.com/read/29162316/the-association-of-maternal-prenatal-vitamin-d-levels-and-child-current-wheeze
#1
Shanda Vereen, Mehmet Kocak, Praveen K Potukuchi, Terryl J Hartman, Frances Tylavsky, Kecia N Carroll
No abstract text is available yet for this article.
November 18, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29154122/broncho-vaxom-in-pediatric-recurrent-respiratory-tract-infections-a-systematic-review-and-meta-analysis
#2
REVIEW
Ju Yin, Baoping Xu, Xiantao Zeng, Kunling Shen
OBJECTIVES: Assess the efficacy and safety of Broncho-Vaxom in pediatric recurrent respiratory tract infections (RRTIs). METHODS: Published randomized controlled trials (RCTs) of Broncho-Vaxom for pediatric RRTI were searched using PubMed, Embase, Cochrane Library, CBM, CNKI, WanFang Data, and VIP databases up to January 2017. Risk of bias was evaluated in accordance to the guidelines of the Cochrane collaboration and the level of evidence was graded according to the GRADE...
November 16, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29151195/risk-factors-in-preschool-children-for-predicting-asthma-during-the-preschool-age-and-the-early-school-age-a-systematic-review-and-meta-analysis
#3
REVIEW
Yixia Bao, Zhimin Chen, Enmei Liu, Li Xiang, Deyu Zhao, Jianguo Hong
PURPOSE OF REVIEW: The aim of this study was to identify risk factors of asthma among children < 6 years old (preschool age) for predicting asthma during the preschool age and early school age (≤ 10 years of age). METHOD OF THE STUDY: MEDLINE, Cochrane, EMBASE, and Google Scholar databases were searched until June 30, 2017. Prospective or retrospective cohort and case-control studies were included. Studies had to have evaluated risk factors or a predictive model for developing asthma in children ≤ 6 years of age or persistent asthma in early school age...
November 18, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29148182/reliability-validity-and-minimal-detectable-change-of-computerised-respiratory-sounds-in-patients-with-chronic-obstructive-pulmonary-disease
#4
Ana Oliveira, Susan Lage, João Rodrigues, Alda Marques
INTRODUCTION: Computerised respiratory Sounds (CRS) are closely related to the movement of air within the tracheobronchial tree, and are promising outcome measures in patients with chronic obstructive pulmonary disease (COPD). However, CRS measurement properties have been poorly tested. OBJECTIVE: To assess the reliability, validity, and the minimal detectable changes (MDC) of CRS in patients with stable COPD. METHODS: Fifty patients (36♂, 67...
November 17, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29147472/recurrent-dyspnea-and-wheezing-pulmonary-function-test-and-dynamic-computed-tomography-may-unfold-the-diagnosis-of-tracheobronchomalacia
#5
REVIEW
Ashish Kumar Roy, Moni Roy, Ghaly Kerolus
Tracheomalacia patients often present with nonspecific symptoms like cough, wheezing and dyspnea. Tracheomalacia diagnosis is usually attributed to alternative common conditions such as asthma or chronic obstructive lung disease. Certain maneuvers, like forced expiration, or recumbent position may elicit subtle signs of tracheomalacia. Ordering novel pulmonary function testing in sitting upright and supine positions may provide additional clues to suspect tracheomalacia, which can be confirmed by either dynamic chest tomography or bronchoscopy...
2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29146301/association-of-sputum-and-blood-eosinophil-concentrations-with-clinical-measures-of-copd-severity-an-analysis-of-the-spiromics-cohort
#6
Annette T Hastie, Fernando J Martinez, Jeffrey L Curtis, Claire M Doerschuk, Nadia N Hansel, Stephanie Christenson, Nirupama Putcha, Victor E Ortega, Xingnan Li, R Graham Barr, Elizabeth E Carretta, David J Couper, Christopher B Cooper, Eric A Hoffman, Richard E Kanner, Eric Kleerup, Wanda K O'Neal, Richard Paine, Stephen P Peters, Neil E Alexis, Prescott G Woodruff, MeiLan K Han, Deborah A Meyers, Eugene R Bleecker
BACKGROUND: Increased concentrations of eosinophils in blood and sputum in chronic obstructive pulmonary disease (COPD) have been associated with increased frequency of exacerbations, reduced lung function, and corticosteroid responsiveness. We aimed to assess whether high eosinophil concentrations in either sputum or blood are associated with a severe COPD phenotype, including greater exacerbation frequency, and whether blood eosinophils are predictive of sputum eosinophils. METHODS: We did a multicentre observational study analysing comprehensive baseline data from SPIROMICS in patients with COPD aged 40-80 years who had a smoking history of at least 20 pack-years, recruited from six clinical sites and additional subsites in the USA between Nov 12, 2010, and April 21, 2015...
November 13, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29144247/the-child-opportunity-index-and-disparities-in-pediatric-asthma-hospitalizations-across-one-ohio-metropolitan-area-2011-2013
#7
Andrew F Beck, Bin Huang, Kathryn Wheeler, Nikki R Lawson, Robert S Kahn, Carley L Riley
OBJECTIVES: To determine whether the Child Opportunity Index (COI), a nationally available measure of relative educational, health/environmental, and social/economic opportunity across census tracts within metropolitan areas, is associated with population- and patient-level asthma morbidity. STUDY DESIGN: This population-based retrospective cohort study was conducted between 2011 and 2013 in a southwest Ohio county. Participants included all children aged 1-16 years with hospitalizations or emergency department visits for asthma or wheezing at a major pediatric hospital...
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29143374/asthma-and-lung-function-in-adulthood-after-a-viral-wheezing-episode-in-early-childhood
#8
Katri Backman, Hertta Ollikainen, Eija Piippo-Savolainen, Kirsi Nuolivirta, Matti Korppi
BACKGROUND: Viral etiology of infection has a significant role in the long-term outcome of early-childhood wheezing. OBJECTIVE: This study examines asthma and lung function in adulthood after early-childhood wheezing induced by respiratory syncytial virus (RSV) and rhinovirus (RV). METHODS: A total of 100 children were hospitalized for a wheezing episode at less than 24 months of age from 1992 to 1993 in Kuopio University Hospital (Finland)...
November 16, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29141272/peripheral-airway-dysfunction-and-relationship-with-symptoms-in-smokers-with-preserved-spirometry
#9
Kanika Jetmalani, Cindy Thamrin, Claude S Farah, Amy Bertolin, David G Chapman, Norbert Berend, Cheryl M Salome, Gregory G King
BACKGROUND AND OBJECTIVE: Smokers develop respiratory symptoms and peripheral airway dysfunction even when spirometry is preserved. Multiple breath nitrogen washout (MBNW) and impulse oscillometry system (IOS) are potentially useful measures of peripheral airway function but they have not been compared in such subjects. We hypothesized that MBNW and IOS are jointly abnormal in smokers with normal spirometry and that these abnormalities relate to respiratory symptoms. METHODS: Eighty smokers with normal spirometry completed a symptom questionnaire, had ventilation heterogeneity in diffusion (Sacin) and convection-dependent (Scond) airways and trapped gas volume at functional residual capacity as a percentage of vital capacity (%VtrFRC/VC) measured by MBNW...
November 15, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29138546/prediction-models-for-exacerbations-in-different-copd-patient-populations-comparing-results-of-five-large-data-sources
#10
Martine Hoogendoorn, Talitha L Feenstra, Melinde Boland, Andrew H Briggs, Sixten Borg, Sven-Arne Jansson, Nancy A Risebrough, Julia F Slejko, Maureen Pmh Rutten-van Mölken
Background and objectives: Exacerbations are important outcomes in COPD both from a clinical and an economic perspective. Most studies investigating predictors of exacerbations were performed in COPD patients participating in pharmacological clinical trials who usually have moderate to severe airflow obstruction. This study was aimed to investigate whether predictors of COPD exacerbations depend on the COPD population studied. Methods: A network of COPD health economic modelers used data from five COPD data sources - two population-based studies (COPDGene(®) and The Obstructive Lung Disease in Norrbotten), one primary care study (RECODE), and two studies in secondary care (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoint and UPLIFT) - to estimate and validate several prediction models for total and severe exacerbations (= hospitalization)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29136347/pro-inflammatory-mediator-responses-from-neonatal-airway-epithelial-cells-and-early-childhood-wheeze
#11
Steve Turner, David Miller, Garry M Walsh, Alison Scaife, Ultan F Power, Michael D Shields, Graham Devereux
BACKGROUND: Airway epithelial cell (AEC) function differs between children with and without asthma. Here, we associated neonatal AEC function with asthma symptoms at 4 years of age. METHODS: Nasal AEC were collected from neonates within 48 h of birth. Cells were cultured and stimulated with tumor necrosis factor alpha/interleukin-1 beta (TNFα/IL-1β), lipopolysaccharide (LPS), or house dust mite (HDM). Absolute concentrations of pro-inflammatory mediators in the culture supernatant were quantified and expressed as median [interquartile range] in pg/mg protein...
November 14, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29135910/sleep-disordered-breathing-in-children-with-recurrent-wheeze-asthma-a-single-centre-study
#12
Marco Zaffanello, Emma Gasperi, Laura Tenero, Michele Piazza, Angelo Pietrobelli, Luca Sacchetto, Franco Antoniazzi, Giorgio Piacentini
The relationship between asthma and sleep-disordered breathing is bidirectional due to common risk factors that promote airway inflammation. Obstructive sleep-disordered breathing and recurrent wheeze/asthma are conditions that involve the upper and the lower respiratory system, respectively. The aim of the present study was to investigate the sleep disordered breathing in children with recurrent wheeze/asthma. This was a retrospective study concerning children older than 2 years who underwent-between January 2014 and November 2016-an in-laboratory overnight polygraphic study...
November 14, 2017: Children
https://www.readbyqxmd.com/read/29132465/-application-of-flexible-bronchoscopy-in-children-with-respiratory-diseases
#13
Li-Ping Wang, Shou-Ping Chen, Yu-Ying Huang, Fang-Fang Qin, Wen Ou, Hong-Dong Liu, Xiao-Fang Deng, Lei Lou, Jing Tao, Yu-Xia Cui
OBJECTIVE: To investigate the significance of flexible bronchoscopy in children with respiratory diseases. METHODS: A retrospective analysis was performed for the clinical data of 80 children who were hospitalized due to respiratory diseases (including severe pneumonia, Mycoplasma pneumoniae pneumonia with atelectasis/lung consolidation/local emphysema, protracted pneumonia, coughing and wheezing of unknown cause, chronic cough of unknown cause, and laryngeal stridor) and who underwent flexible bronchoscopy/alveolar lavage...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29131887/effect-of-an-intervention-to-promote-breastfeeding-on-asthma-lung-function-and-atopic-eczema-at-age-16-years-follow-up-of-the-probit-randomized-trial
#14
Carsten Flohr, A John Henderson, Michael S Kramer, Rita Patel, Jennifer Thompson, Sheryl L Rifas-Shiman, Seungmi Yang, Konstantin Vilchuck, Natalia Bogdanovich, Mikhail Hameza, Richard M Martin, Emily Oken
Importance: Atopic diseases, including asthma and atopic eczema, are the most common chronic conditions of childhood. Objective: To investigate whether an intervention to promote prolonged and exclusive breastfeeding protects against asthma, atopic eczema, and low lung function in adolescence. Design, Setting, and Participants: Follow-up of the Promotion of Breastfeeding Intervention Trial (PROBIT), a cluster randomized trial in 30 Belarusian maternity hospitals and affiliated polyclinics; recruitment of 17 046 healthy term infants took place from June 15, 1996, to December 31, 1997...
November 13, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29128708/childhood-brain-tumours-early-infections-and-immune-stimulation-a-pooled-analysis-of-the-escale-and-estelle-case-control-studies-sfce-france
#15
Judith E Lupatsch, Helen D Bailey, Brigitte Lacour, Christelle Dufour, Anne-Isabelle Bertozzi, Pierre Leblond, Cécile Faure-Conter, Isabelle Pellier, Claire Freycon, François Doz, Stéphanie Puget, Stéphane Ducassou, Laurent Orsi, Jacqueline Clavel
BACKGROUND: Few studies have investigated whether early infections and factors potentially related to early immune stimulation might be involved in the aetiology of childhood brain tumours (CBT). In this study, we investigated the associations between CBT with early day-care attendance, history of early common infections, atopic conditions (asthma/wheezing, eczema, allergic rhinitis), early farm residence/visits and contact with animals. METHODS: We pooled data from two nationwide French case-control studies, the ESCALE and ESTELLE studies...
November 10, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29127129/heart-failure-in-dilated-cardiomyopathy-mimicking-asthma-triggered-by-pneumonia
#16
Kenichi Tetsuhara, Satoshi Tsuji, Katsutoshi Nakano, Mitsuru Kubota
Heart failure is a rare cause of wheezing and may develop into a critical condition in children. Few cases report patients with heart failure, secondary to dilated cardiomyopathy, with high fever. A 23-month-old girl visited the emergency department with high fever, cough, first wheezing episode, chest retraction and tachycardia. The chest X-ray revealed consolidation on the left lower lung field; the cardiothoracic ratio was 60%. She was diagnosed with bronchial asthma triggered by pneumonia, which remained unchanged during four visits...
November 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29122909/critical-pitfall-another-cause-of-wheezing
#17
Takeshi Saraya, Hiroki Nunokawa, Mitsuru Sada, Hajime Takizawa
No abstract text is available yet for this article.
November 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29119851/clinical-characteristics-of-children-infected-with-enterovirus-d68-in-an-outpatient-clinic-and-the-association-with-bronchial-asthma
#18
Tsutomu Itagaki, Yoko Aoki, Yohei Matoba, Shizuka Tanaka, Tatsuya Ikeda, Katsumi Mizuta, Yoko Matsuzaki
BACKGROUND: All reports of increases in severe respiratory disease associated with human enterovirus D68 (EV-D68) are from hospital settings. However, there are few reports describing clinical characteristics in less severely affected populations. METHODS: We conducted a retrospective observational study from January 2010 to December 2015 in Yamagata, Japan. Using regional passive surveillance, 5794 respiratory specimens were collected from children who initially presented to an outpatient clinic with acute respiratory symptoms...
November 9, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29117468/zoonotic-helminth-exposure-and-risk-of-allergic-diseases-a-study-of-two-generations-in-norway
#19
Nils Oskar Jõgi, Cecilie Svanes, Silver Peeter Siiak, Erin Logan, John W Holloway, Jannicke Igland, Ane Johannessen, Michael Levin, Francisco Gomez Real, Vivi Schlunssen, William G C Horsnell, Randi J Bertelsen
BACKGROUND: Animal and human studies indicate that definitive host helminth infections may confer protection from allergies. However, zoonotic helminths, such as Toxocara species (spp.), have been associated with increased allergies. OBJECTIVE: We describe the prevalence of Toxocara spp. and Ascaris spp. seropositivity, and associations with allergic diseases and sensitisation, in two generations in Bergen, Norway. METHODS: Serum levels of total IgG4, anti-Toxocara spp...
November 8, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29116535/prevalence-of-asthma-and-associated-factors-among-male-late-adolescents-in-tabriz-iran
#20
Mohammad Ghanbari Ghozikali, Khalil Ansarin, Kazem Naddafi, Ramin Nabizadeh Nodehi, Kamyar Yaghmaeian, Mohammad Sadegh Hassanvand, Masud Yunesian
Asthma is an important chronic disease all over the world. The aim of this study was to determine the prevalence of asthma in a population of male late adolescents and its association with some contributing risk factors in northwest of Iran. This cross-sectional study was carried out in selected high schools of Tabriz, Iran, in 2016. The asthma prevalence and patient background information were examined using a questionnaire that prepared by the ISAAC. One hundred forty-two out of 1134 subjects (12.4%) identified to have asthma, 23...
November 8, 2017: Environmental Science and Pollution Research International
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