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https://www.readbyqxmd.com/read/29779923/a-viral-vectored-rsv-vaccine-induces-long-lived-humoral-immunity-in-cotton-rats
#1
Jessica L Grieves, Zhiwei Yin, Adolfo Garcia-Sastre, Ignacio Mena, Mark E Peeples, Heidi P Risman, Hannah Federman, Marvin J Sandoval, Russell K Durbin, Joan E Durbin
Human respiratory syncytial virus (RSV) is the leading cause of lower airway disease in infants worldwide and repeatedly infects immunocompetent individuals throughout life. Severe lower airway RSV infection during infancy can be life-threatening, but is also associated with important sequelae including development of asthma and recurrent wheezing in later childhood. The basis for the inadequate, short-lived adaptive immune response to RSV infection is poorly understood, but it is widely recognized that RSV actively antagonizes Type I interferon (IFN) production...
May 17, 2018: Vaccine
https://www.readbyqxmd.com/read/29779007/is-oral-dexamethasone-as-good-as-oral-prednisolone-for-childhood-wheeze-requiring-steroids
#2
Jiske Steensma, Chris Bird
No abstract text is available yet for this article.
May 19, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29769485/changes-of-peak-expiratory-flow-rate-in-adult-asthmatic-patient
#3
S Nasreen, A Nessa, F Islam, A Khanam, R Sultana, R Rahman, M Hossain
Asthma is a common pulmonary disorder characterizerized by airway inflammation, airway- hyper reactivity, and reversible airflow obstruction. The classic triad of symptoms is wheezing, chronic episodic dyspnea and chronic cough. The prevalence of asthma increased steadily over the latter part of the last century, first in the developed and then in the developing world. The number of people with asthma in the world may be as high as 334 million. Asthma in Bangladesh appears to be a substantial public health problem: an estimated 11...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29768461/pet-keeping-in-childhood-and-asthma-and-allergy-among-children-in-tianjin-area-china
#4
Shugang Luo, Yuexia Sun, Jing Hou, Xiangrui Kong, Pan Wang, Qingnan Zhang, Jan Sundell
This study aims to find out the relationship between pet keeping in childhood and asthma and allergy among children aged 0-8 years old in Tianjin, China. Parental or guardians reports of 7360 children were analyzed. 1490 (21.6%) families kept pets at the time of the survey (current), among them 4.0% cats, and 14.7% dogs. For the first year of life of children (early), 1196 (18.4%) families kept pets, and among them 3.2% cats, and 13.7% dogs. Exposure to a pet in early childhood significantly increased the risk of current wheeze, current dry cough, and diagnosed rhinitis...
2018: PloS One
https://www.readbyqxmd.com/read/29768270/associations-of-current-wheeze-and-body-mass-index-with-perennial-and-seasonal-allergic-rhinitis-in-young-adults
#5
Munehiro Matsumoto, Satoshi Konno, Hirokazu Kimura, Nozomu Takei, Hiroki Kimura, Kaoruko Shimizu, Houman Goudarzi, Masaru Suzuki, Satoshi Hashino, Masaharu Nishimura
BACKGROUND: The coexistence of asthma and allergic rhinitis (AR) and its distinct association with obesity have been reported. However, few studies have differentiated the two types of AR, i.e., perennial (PAR) and seasonal AR (SAR), with regard to their associations with asthma and obesity. The aim of this study was to evaluate the coexistence of current wheeze and two types of AR and the impact of body mass index (BMI) on these two conditions in Japanese young adults. METHODS: First-year students from Hokkaido University were enrolled into this study from 2011 to 2016...
May 16, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29764459/health-related-quality-of-life-by-allergy-symptoms-in-elementary-school-students
#6
Sang-Kyu Kim, Min-Woo Jo, Seon-Ha Kim
BACKGROUND: Globally, allergic diseases are very common in childhood and may affect children's quality of life. This study aimed to explore health-related quality of life of elementary school students with allergy symptoms using the EQ-5D-Y and to examine the validity and feasibility of the EQ-5D-Y. METHODS: The study subjects were the students within 50 elementary schools which voluntarily participated in research project. In this sample population, the EQ-5D-Y questionnaire was self-administered by the students, and demographic and health information were collected from the student's parents...
May 15, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29762532/pregnancy-trimester-specific-exposure-to-ambient-air-pollution-and-child-respiratory-health-outcomes-in-the-first-2-years-of-life-effect-modification-by-maternal-pre-pregnancy-bmi
#7
Shu-E Soh, Anne Goh, Oon Hoe Teoh, Keith M Godfrey, Peter D Gluckman, Lynette Pei-Chi Shek, Yap-Seng Chong
Prenatal exposure to air pollution is associated with childhood respiratory health; however, no previous studies have examined maternal pre-pregnancy body mass index (BMI) as a potential effect modifier. We investigated whether maternal pre-pregnancy BMI modified the association of trimester-specific air pollution divided into quartiles of exposure (Q1⁻4) on respiratory health in the Growing Up in Singapore towards healthy Outcomes (GUSTO) study ( n = 953) in 2-year-old children. For episodes of wheezing, children of overweight/obese mothers and who were exposed to particulate matter less than 2...
May 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29761786/association-of-a-four-locus-gene-model-including-il13-il4-fcer1b-and-adrb2-with-the-asthma-predictive-index-and-atopy-in-chinese-han-children
#8
S Bai, L Hua, X Wang, Q Liu, Y Bao
BACKGROUND AND OBJECTIVE: Asthma is a complex and heterogeneous disease. We found that gene-gene interactions among IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 in asthmatic children of Chinese Han nationality. This four-locus set constituted an optimal statistical interaction model. Objective: This study examined associations of the four-gene model consisting of IL13, IL4, FCER1B, and ADRB2 with the Asthma Predictive Index (API) and atopy in Chinese Han children...
May 11, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29760926/diffuse-endobronchial-metastasis-from-sigmoid-carcinoma-presenting-as-wheezing-and-respiratory-failure
#9
Nattawat Jantarangsi, Poonchavist Chantranuwatana, Naricha Chirakalwasan
A 66-year-old Thai man with underlying asthma, history of traumatic right haemothorax, and sigmoid carcinoma with bladder invasion developed productive cough, whitish sputum, dyspnoea, and wheezing for 2 months. Physical examination showed generalized expiratory wheezing in both lungs. Computed tomography scan of the chest revealed diffuse thickening of bronchial wall, predominantly at lower lobes; several various sizes of pulmonary nodules; diffuse interlobular septal thickening; multiple enlarged mediastinal lymph nodes and hilar lymph nodes; and right pleural effusion...
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29760843/multicenter-study-of-albuterol-use-among-infants-hospitalized-with-bronchiolitis
#10
Anna Condella, Jonathan M Mansbach, Kohei Hasegawa, Peter S Dayan, Ashley F Sullivan, Janice A Espinola, Carlos A Camargo
Introduction: Although bronchiolitis is a common reason for infant hospitalization, significant heterogeneity persists in its management. The American Academy of Pediatrics currently recommends that inhaled albuterol not be used in routine care of children with bronchiolitis. Our objective was to identify factors associated with pre-admission (e.g., emergency department or primary care) use of albuterol among infants hospitalized for bronchiolitis. Methods: We analyzed data from a 17-center observational study of 1,016 infants (age <1 year) hospitalized with bronchiolitis between 2011-2014...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29757892/exposures-to-single-use-detergent-sacs-reported-to-a-statewide-poison-control-system-2013-2015
#11
Rais Vohra, Serena Huntington, Yelena Fenik, Derek Phan, Nancy Ta, Richard J Geller
BACKGROUND: Single-use detergent sacs (SUDSs) represent a relatively new household hazard to children. Brand differences and packaging changes may contribute to differential risks with accidental exposure. We sought to identify high-risk features from SUDS exposures in children and to assess whether product packaging changed trends in SUDS exposures reported to poison centers. METHODS: In this institutional review board-approved, retrospective chart review of SUDS exposures from January 2013 to August 2015, deidentified case records of a large statewide poison control system were extracted and analyzed for clinical associations and trends...
May 2, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29756989/under-diagnosis-and-over-diagnosis-of-asthma
#12
Shawn D Aaron, Louis Philippe Boulet, Helen K Reddel, Andrea Gershon
Asthma is diagnosed based on patients' respiratory symptoms of wheeze, cough, chest tightness and/or dyspnea together with physiologic evidence of variable and reversible expiratory airflow limitation. In the United States 7.6% of adults and 8.4% of children self-report a physician diagnosis of current asthma. Population-based studies in children, adults and the elderly suggest that from 20% to 70% of asthmatics in the community remain undiagnosed and hence untreated. Under-diagnosis of asthma has been found to be associated with under-reporting of respiratory symptoms by patients to their physicians as well as poor socio-economic status...
May 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29755960/long-sun-exposures-influencing-high-sub-cutaneous-synthesis-of-vitamin-d3-may-be-associated-with-exacerbation-of-symptoms-in-allergic-asthma
#13
L G D'Cruz, S A Husain, T Wells, C Morgan, P J Stanczyk, A Satgunarajah, J Kashir, B L Calver, L M Blayney, F A Lai
Objectives: Does excessive sun-exposure, non-use of sunscreen and/or high doses of vitamin-D3 supplements provoke exacerbation of asthma? Design: Clinical examinations, retrospective records-access and questionnaire surveys were distributed to a convenience sample of allergic-asthma patient (n=183). Setting: Patients (19-89 years) attending the outpatient respiratory clinics at Maidstone Hospital were enrolled. Results: 90...
March 26, 2018: Journal of Aging Research & Clinical Practice
https://www.readbyqxmd.com/read/29754411/a-case-study-of-nurse-practitioner-care-compared-to-general-practitioner-care-for-children-with-respiratory-tract-infections
#14
Saskia F van Vugt, Alma C van de Pol, Frits G W Cleveringa, Rebecca K Stellato, Marieke P Kappers, Niek J de Wit, Roger A M J Damoiseaux
AIM: To compare quality of care provided by nurse practitioners with care provided by general practitioners for children with respiratory tract infections in the Netherlands. BACKGROUND: Nurse practitioners increasingly manage acute conditions in general practice, with opportunities for more protocolled care. Studies on quality of nurse practitioners' care for children with respiratory tract infections are limited to the US health care system and do not take into account baseline differences in illness severity...
May 13, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29748253/prevalence-estimates-and-risk-factors-for-early-childhood-wheeze-across-europe-the-europrevall-birth-cohort
#15
Anna Selby, Alasdair Munro, Kate E Grimshaw, Victoria Cornelius, Thomas Keil, Linus Grabenhenrich, Michael Clausen, Ruta Dubakiene, Alessandro Fiocchi, Marek L Kowalski, Nikolaos G Papadopoulos, Marta Reche, Sigurveig T Sigurdardottir, Aline B Sprikkelman, Paraskevi Xepapadaki, E N Clare Mills, Kirsten Beyer, Graham Roberts
BACKGROUND: Preschool wheeze is an important problem worldwide. No comparative population-based studies covering different countries have previously been undertaken. OBJECTIVE: To assess the prevalence of early childhood wheeze across Europe and evaluate risk factors focusing on food allergy, breast feeding and smoke exposure. METHODS: Infants from nine countries were recruited into the EuroPrevall birth cohort. At 12 and 24 months, data on wheeze, allergic signs/symptoms, feeding, smoke exposure, infections and day care attendance were collected using questionnaires...
May 10, 2018: Thorax
https://www.readbyqxmd.com/read/29746377/risk-factors-for-severe-community-acquired-pneumonia-among-children-hospitalized-with-cap-younger-than-5-years-of-age
#16
Wei Shan, Ting Shi, Kaile Chen, Jian Xue, Yin Wang, Jia Yu, Genming Zhao, Jianmei Tian, Tao Zhang
BACKGROUND: CAP causes great morbidity and mortality as well as enormous economic burden worldwide. This study intended to describe the clinical characteristics of CAP and explore the risk factors of severe CAP among children in downtown Suzhou, China. METHODS: This was a retrospective study of childhood hospitalizations in Soochow University Affiliated Children's Hospital (SCH) from January 1, 2010 to December 31, 2014. Children who were residents of downtown Suzhou, 29 days to <5 years of age, with discharge diagnosis codes (ICD-10) J09 to J18 and J20 to J22 were included...
May 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29743784/high-prevalence-of-chronic-respiratory-symptoms-among-autorickshaw-drivers-of-urban-puducherry-south-india
#17
Peter Stephen, Thulasingam Mahalakshmy, Rajaram Manju, Karthik B Laksham, Sudalai Subramani, Kanhu Panda, Sonali Sarkar
Context: Auto-rickshaw (three wheelers open cabin type of vehicle) drivers are exposed to traffic air pollution. Studies have demonstrated reduced pulmonary function among drivers. However, limited studies have determined the prevalence of chronic respiratory symptoms or chronic obstructive pulmonary disease (COPD) among drivers. Aims: Among auto-rickshaw drivers of urban Puducherry to determine prevalence of (i) chronic respiratory symptoms by using Indian Study on Epidemiology of Asthma, Respiratory Symptoms, and Chronic Bronchitis (INSEARCH) questionnaire and (ii) COPD by measuring peak expiratory flow rate (PEFR)...
January 2018: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29742646/burden-of-human-metapneumovirus-and-respiratory-syncytial-virus-infections-in-asthmatic-children
#18
Takashi Furuta, Shunji Hasegawa, Makoto Mizutani, Takashi Iwai, Noriko Ohbuchi, Shoji Kawano, Norimichi Tashiro, Masashi Uchida, Masanari Hasegawa, Masashi Motoyama, Takaomi Sekino, Kenji Nakatsuka, Kiyoshi Ichihara, Komei Shirabe, Shouichi Ohga
BACKGROUND: Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are the leading causes of acute respiratory illness in children. Clinical burden of each infection on the respiratory distress in asthmatic patients remains unclear. The purpose of the study is to clarify the effect of these infections on the severity of asthmatic children in the seasonal outbreaks. METHODS: A total of 1,217 pediatric inpatients with hMPV (n=114) or RSV (n=1,103) infection in Yamaguchi prefecture, Japan between 2011 and 2014 were enrolled...
May 4, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29741642/a-cross-sectional-surveillance-study-of-the-frequency-and-etiology-of-acute-respiratory-illness-among-pregnant-women
#19
Anne M Hause, Vasanthi Avadhanula, Maurizio L Maccato, Phillip M Pinell, Nanette Bond, Patricia Santarcangelo, Laura Ferlic-Stark, Flor M Munoz, Pedro A Piedra
Background: Other than influenza, little is known about the consequences of viral acute respiratory illness (ARI) on pregnant women and fetuses. Our objectives were to determine the frequency of ARI due to respiratory viruses and the associated clinical outcomes during pregnancy. Methods: Pregnant women in their second or third trimester were enrolled if they reported having symptoms of ARI or were healthy within the preceding 2 weeks. Nasopharyngeal secretions were evaluated for respiratory viruses by molecular diagnostic assays...
May 5, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29736695/severe-asthma-challenges-and-pitfalls-in-management
#20
REVIEW
Anirban Maitra
A small but significant subset of asthmatic children show a lack of response to standard management, resulting in further intensification of therapy to optimise symptom control and may remain symptomatic despite maximal therapy. Severe asthma results in increased risk of adverse outcomes whilst contributing significantly to the economic burden on the nation's health resources. The ERS / ATS guidelines were published in 2014 and form the basis of identifying, evaluating and managing severe asthmatic children...
May 7, 2018: Indian Journal of Pediatrics
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