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Allergic rhinitis and comorbidities

Naghmeh Radhakrishna, Tunn Ren Tay, Fiona Hore-Lacy, Robert Stirling, R Hoy, Eli Dabscheck, Mark Hew
Objective Multiple extra-pulmonary comorbidities contribute to difficult asthma, but their diagnosis can be challenging and time consuming. Previous data on comorbidity detection have focused on clinical assessment, which may miss certain conditions. We aimed to locate relevant validated screening questionnaires to identify extra-pulmonary comorbidities that contribute to difficult asthma, and evaluate their performance during a difficult asthma evaluation. Methods MEDLINE was searched to identify key extra-pulmonary comorbidities that contribute to difficult asthma...
October 7, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Chih-Ying Lee, Mu-Hong Chen, Mei-Jy Jeng, Ju-Wei Hsu, Shih-Jen Tsai, Ya-Mei Bai, Giun-Yi Hung, Hsiu-Ju Yen, Tzeng-Ji Chen, Tung-Ping Su
Atopic dermatitis (AD) is one of the common allergic diseases in children. The presence of allergic diseases was found to have association with the risk of developing attention-deficit hyperactivity disorder (ADHD) or autistic spectrum disorder (ASD) in children, but it is still inconclusive. This study was to investigate the longitudinal relationship between AD developed during toddlerhood and subsequent development of ADHD or ASD in later childhood. Toddlers born between 1998 and 2008 and diagnosed with AD at the age younger than 3 years and older than 1 month were retrieved from Taiwan's National Health Insurance Research Database...
September 2016: Medicine (Baltimore)
Dan Xu, Yingshuo Wang, Zhimin Chen, Shuxian Li, Yungai Cheng, Li Zhang, Lingzhi Zhao
BACKGROUND: Asthma is a global problem. Prevalence varies among different countries and cities. We aimed to obtain the prevalence, describe the characteristics, and discover factors that may relate to asthma in Hangzhou. METHODS: This cross-sectional study was conducted in Hangzhou. The subjects were children aged 14 years and younger. A control group of non-asthma children that matched in age and sex with each asthmatic patient was also randomly selected and interviewed...
September 27, 2016: Respiratory Research
Pascal Demoly, Yoshitaka Okamoto, William H Yang, Philippe Devillier, Karl-Christian Bergmann
INTRODUCTION: The once-daily 300 index of reactivity (IR) house dust mite (HDM) tablet (Actair®; Stallergenes Greer, Antony, France/Shionogi & Co. Ltd., Osaka, Japan) is the first sublingual immunotherapy (SLIT) tablet to be approved for the treatment of HDM-induced allergic rhinitis. AREAS COVERED: This drug profile reviews the current body of evidence on the efficacy, safety and tolerability of the 300 IR HDM tablet, its pharmacodynamics, and its role in clinical practice...
September 15, 2016: Expert Review of Clinical Immunology
Louis Jacob, Thomas Keil, Karel Kostev
BACKGROUND: Using routine healthcare data, the goal of this study was to examine the association between asthma and comorbid disorders in children in Germany. METHODS: Patients with a diagnosis of asthma documented by a German pediatrician in 2015 were identified. Demographic data included age and gender. Patients younger than 6 and older than 17 and individuals followed for less than a year before index date were excluded. Each patient was matched for age, sex, and physician with an asthma-free control...
October 5, 2016: Pediatric Allergy and Immunology
Chieh-Hsin Wu, Zi-Hao Zhang, Ming-Kung Wu, Chiu-Huan Wang, Ying-Yi Lu, Chih-Lung Lin
BACKGROUND: Osteoporosis and migraine are both important public health problems and may have overlapping pathophysiological mechanisms. The aim of this study was to use a Taiwanese population-based dataset to assess migraine risk in osteoporosis patients. METHODS: The Taiwan National Health Insurance Research Database was used to analyse data for 40,672 patients aged ≥20 years who had been diagnosed with osteoporosis during 1996-2010. An additional 40,672 age-matched patients without osteoporosis were randomly selected as the non-osteoporosis group...
2016: SpringerPlus
Miguel Román-Rodríguez, Job F M van Boven, Freya Vargas, Cecilia C Contreras, Gema Lamelas, Salvador Gestoso, Miguel Góngora, Maite Corredor, Magdalena Esteva
BACKGROUND: There is a worldwide over-prescription of inhaled corticosteroids (ICS) in patients with chronic obstructive pulmonary disease (COPD), off-label prescribing, and unnecessary prescription of high doses. OBJECTIVES: Our aim was to assess the prescription rate of ICS and to identify sociodemographic and clinical factors associated with ICS prescription among patients with COPD, treated in Balearic primary healthcare. METHODS: This cross-sectional study included all patients with a clinical COPD diagnosis, who attended a primary care centre of the Balearic Islands (Spain) during 2012...
September 6, 2016: European Journal of General Practice
Ozlem Atan Sahin, Nuray Kececioglu, Muhittin Serdar, Aysel Ozpinar
BACKGROUND: There are many consequences of mold exposure related to respiratory system health of children This retrospective cohort study aims to find the association between adenoid hypertrophy and mold exposure in children living in damp environments. METHODS: Children with history of recurrent respiratory tract infections were enrolled in the study between June 2012 and June 2013 and were followed up for adenoid hypertrophy from June 2013 to June 2016. One hundred and forty two children were residents of moldy houses and 242 were living in normal houses...
September 2016: International Journal of Pediatric Otorhinolaryngology
Kathrin Damm, Janina Volk, Andreas Horn, Jean-Pierre Allam, Ninette Troensegaard-Petersen, Niels Serup-Hansen, Thomas Winkler, Ivonne Thiessen, Kathrin Borchert, Eike G Wüstenberg, Thomas Mittendorf
BACKGROUND: Allergic Rhinitis (AR) is a common disorder in Europe with Allergic Asthma (AA) as a frequent comorbidity. Allergy immunotherapy (AIT) is the only causal therapy of AR and AA, and can be administered as subcutaneous injections at the physician or as sublingual drops or tablets at home. The usual treatment duration is 3 years. OBJECTIVE: This study aimed to elicit patient preferences to identify the AIT administration mode preferred by patients. METHODS: A discrete-choice-experiment (DCE) was developed to determine how people weight different treatment options using a paper-based questionnaire from June to September 2014, including 16 study centres...
December 2016: Health Economics Review
Hung-Rong Yen, Wan-Yu Lai, Chih-Hsin Muo, Mao-Feng Sun
Background Large-scale surveys of complementary traditional Chinese medicine (TCM) use in pediatric cancer patients are lacking. The aim of our study was to investigate the use of TCM in pediatric cancer patients. Methods We analyzed cancer patients younger than 18 years (n = 12 965) who were registered in the National Health Insurance Research Database in Taiwan between 2001 and 2011. Patients were categorized into TCM or non-TCM users based on their use of TCM. Results In Taiwan, 8086 (62.4%) children with cancer sought TCM treatment at some point...
July 12, 2016: Integrative Cancer Therapies
Sumit Bose, Leslie C Grammer, Anju T Peters
Chronic rhinosinusitis (CRS) is a persistent inflammatory disease that affects a multitude of people worldwide. The pathogenesis of CRS involves many factors including genetics, status of the sinonasal microbiome, infections, and environmental influences. Comorbidities associated with CRS include asthma, allergic rhinitis, bronchiectasis, and certain kinds of immunodeficiency. CRS can be divided into different subtypes based on endotypes and phenotypes. Infectious CRS is one such category. The etiology of infectious CRS is usually secondary to chronic bacterial infection that commonly begins with a viral upper respiratory tract infection...
July 2016: Journal of Allergy and Clinical Immunology in Practice
B J Pelz, J B Wechsler, K Amsden, K Johnson, A M Singh, B K Wershil, A F Kagalwalla, P J Bryce
BACKGROUND: Links between food allergens and eosinophilic esophagitis (EoE) have been established, but the interplay between EoE- and IgE-associated immediate hypersensitivity to foods remains unclear. OBJECTIVE: We sought to determine the prevalence of IgE-associated food allergy at the time of diagnosis of EoE in children and to determine whether differences existed in presentation and disease compared to subjects with EoE alone. METHODS: Eosinophilic esophagitis patients were stratified based on the diagnosis of IgE-associated immediate hypersensitivity (EoE + IH vs...
July 8, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Thomas Delate, Nathan Rader, Daniel W Jenkins, Ryan Lowe
OBJECTIVE: The goal of this study was to examine the impact of a multi-disciplinary intervention designed to improve appropriate albuterol inhaler utilization among patients with asthma. METHODS: This was a pre-post retrospective analysis. The study intervention included written information sent directly to patients, educated prescribers, and enhanced pharmacist training on appropriate albuterol inhaler utilization. Eligible study patients had a diagnosis of asthma and purchased at least two albuterol inhalers between 07/12/2012 and 06/30/2013 (pre-period) and 7/01/2013 to 06/30/2014 (post-period)...
July 6, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Zhenhong Li, Jocelyn Celestin, Richard F Lockey
Obstructive sleep apnea syndrome (OSAS) may be central neurologic (<5%) or obstructive (>95%) in origin and is a relatively prevalent condition in children. It affects 1%-5% of children aged 2-8 years and is caused by a variety of different pathophysiologic abnormalities. Cardiovascular, metabolic, and neurocognitive comorbidities can occur in both children and adults when left untreated. It also can cause severe behavioral problems in children. The American Academy of Pediatrics recommends that all children be screened with an appropriate history and physical examination for symptoms and signs suggestive of OSAS...
September 2016: Journal of Allergy and Clinical Immunology in Practice
Niyazi Altıntoprak, Murat Kar, Nuray Bayar Muluk, Tugba Oktemer, Kagan Ipci, Leman Birdane, Mitat Aricigil, Mehmet Senturk, Sameer Ali Bafaqeeh, Cemal Cingi
We here provide an update on the literature regarding local allergic rhinitis (LAR). In reviewing LAR, we have included an updated definition, classifications, mechanisms, comorbidities, and recommendations for diagnosis and treatment for LAR, as well as the defined research areas for future evidence-based studies. LAR is a localised nasal allergic response in the absence of systemic atopy characterised by local production of specific IgE (sIgE) antibodies, a TH2 pattern of mucosal cell infiltration during natural exposure to aeroallergens, and a positive nasal allergen provocation test response, with the release of inflammatory mediators...
August 2016: International Journal of Pediatric Otorhinolaryngology
Joo Kyung Kim, Soo Haeng Lee, Bho Hyeon Lee, Chang Youl Lee, Do Jin Kim, Kyung Hoon Min, Sung Kyoung Kim, Kwang Ha Yoo, Ki-Suck Jung, Yong Il Hwang
INTRODUCTION: COPD exacerbation negatively impacts the patient's quality of life and lung function, increases mortality, and increases socioeconomic costs. In a real-world setting, the majority of patients with COPD have mild-to-moderate airflow limitation. Therefore, it is important to evaluate COPD exacerbation in patients with mild-to-moderate airflow limitation, although most studies have focused on the patients with moderate or severe COPD. The objective of this study was to evaluate factors associated with COPD exacerbation in patients with mild-to-moderate airflow limitation...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Tunn Ren Tay, Naghmeh Radhakrishna, Fiona Hore-Lacy, Catherine Smith, Ryan Hoy, Eli Dabscheck, Mark Hew
BACKGROUND AND OBJECTIVE: Little is known about how comorbidities affect difficult asthma patients across different domains of asthma outcomes. We hypothesized that comorbidities in difficult asthma significantly influence asthma outcomes. METHODS: We analysed 90 consecutive patients who underwent systematic assessment at our hospital's difficult asthma clinic. Eight comorbidities were assessed in all patients. They were allergic rhinitis, chronic rhinosinusitis (CRS), gastroesophageal reflux disease, obesity, obstructive sleep apnoea, anxiety or depression, dysfunctional breathing (DB) and vocal cord dysfunction (VCD)...
July 1, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
P G Gibson, H Reddel, V M McDonald, G Marks, C Jenkins, A Gillman, J Upham, M Sutherland, J Rimmer, F Thien, G P Katsoulotos, M Cook, I Yang, C Katelaris, S Bowler, D Langton, P Robinson, C Wright, V Yozghatlian, S Burgess, P Sivakumaran, A Jaffe, J Bowden, P A B Wark, K Y Yan, V Kritikos, M Peters, M Hew, A Aminazad, M Bint, M Guo
BACKGROUND: Severe asthma is a high impact disease. Omalizumab targets the allergic inflammatory pathway; however, effectiveness data in a population with significant comorbidities are limited. AIMS: To describe severe allergic asthma, omalizumab treatment outcomes and predictors of response among the Australian Xolair Registry participants. METHODS: A web-based post-marketing surveillance registry was established to characterise the use, effectiveness and adverse effects of omalizumab (Xolair) for severe allergic asthma...
September 2016: Internal Medicine Journal
Jayanta Gupta, Elisabet Johansson, Jonathan A Bernstein, Ranajit Chakraborty, Gurjit K Khurana Hershey, Marc E Rothenberg, Tesfaye B Mersha
Atopic dermatitis (AD), food allergy, allergic rhinitis, and asthma are common atopic disorders of complex etiology. The frequently observed atopic march from early AD to asthma, allergic rhinitis, or both later in life and the extensive comorbidity of atopic disorders suggest common causal mechanisms in addition to distinct ones. Indeed, both disease-specific and shared genomic regions exist for atopic disorders. Their prevalence also varies among races; for example, AD and asthma have a higher prevalence in African Americans when compared with European Americans...
September 2016: Journal of Allergy and Clinical Immunology
Mahboobeh Mahdavinia, Faraz Bishehsari, Waqas Hayat, Christopher D Codispoti, Shahram Sarrafi, Inna Husain, Arpita Mehta, Mohamed Benhammuda, Mary C Tobin, Sindhura Bandi, Philip S LoSavio, Jill S Jeffe, Erica L Palmisano, Robert P Schleimer, Pete S Batra
BACKGROUND: An association between chronic rhinosinusitis (CRS) and gastroesophageal reflux disease (GERD) has been previously reported; however, the underlying factors linking CRS and GERD remain to be elucidated. OBJECTIVE: To assess the association of GERD and CRS using prospective and retrospective approaches. METHODS: The retrospective study comprised a large cohort of CRS cases, whereas the prospective arm evaluated a series of CRS cases and controls...
August 2016: Annals of Allergy, Asthma & Immunology
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