keyword
https://read.qxmd.com/read/38536822/immediate-postnatal-prediction-of-death-or-bronchopulmonary-dysplasia-among-very-preterm-and-very-low-birth-weight-infants-based-on-gradient-boosting-decision-trees-algorithm-a-nationwide-database-study-in-japan
#1
JOURNAL ARTICLE
Kota Yoneda, Tomohisa Seki, Yoshimasa Kawazoe, Kazuhiko Ohe, Naoto Takahashi
INTRODUCTION: Bronchopulmonary dysplasia (BPD) poses a substantial global health burden. Individualized treatment strategies based on early prediction of the development of BPD can mitigate preterm birth complications; however, previously suggested predictive models lack early postnatal applicability. We aimed to develop predictive models for BPD and mortality based on immediate postnatal clinical data. METHODS: Clinical information on very preterm and very low birth weight infants born between 2008 and 2018 was extracted from a nationwide Japanese database...
2024: PloS One
https://read.qxmd.com/read/38536661/trial-of-labor-after-2-previous-cesareans-a-multicenter-study
#2
JOURNAL ARTICLE
Yael Gold Zamir, Tzuria Peled, Hila Hochler, Hen Y Sela, Ari Weiss, Michal Lipschuetz, Joshua Isaac Rosenbloom, Sorina Grisaru-Granovsky, Misgav Rottenstreich
BACKGROUND: Trial of labor after cesarean after 2 cesarean deliveries is linked to a lower success rate of vaginal delivery and higher rates of adverse obstetrical outcomes than trial of labor after cesarean after 1 previous cesarean delivery. OBJECTIVE: This study aimed to investigate the factors associated with failed trial of labor after cesarean among women with 2 previous cesarean deliveries. STUDY DESIGN: This was a multicenter retrospective cohort study, which included all women with singleton pregnancies attempting trial of labor after cesarean after 2 previous cesarean deliveries between 2003 and 2021...
December 1, 2023: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/38535883/sustaining-the-continued-effectiveness-of-an-antimicrobial-stewardship-program-in-preterm-infants
#3
JOURNAL ARTICLE
Tommaso Zini, Francesca Miselli, Chiara D'Esposito, Lucia Fidanza, Riccardo Cuoghi Costantini, Lucia Corso, Sofia Mazzotti, Cecilia Rossi, Eugenio Spaggiari, Katia Rossi, Licia Lugli, Luca Bedetti, Alberto Berardi
BACKGROUND: There are wide variations in antibiotic use in neonatal intensive care units (NICUs). Limited data are available on antimicrobial stewardship (AS) programs and long-term maintenance of AS interventions in preterm very-low-birth-weight (VLBW) infants. METHODS: We extended a single-centre observational study carried out in an Italian NICU. Three periods were compared: I. "baseline" (2011-2012), II. "intervention" (2016-2017), and III. "maintenance" (2020-2021)...
March 7, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535563/lung-microbiota-and-ventilator-associated-pneumonia-in-the-neonatal-period
#4
REVIEW
Fermín García-Muñoz Rodrigo, Lourdes Urquía Martí, Marta Siguero Onrubia, Moreyba Borges Luján, Gloria Galán Henríquez, Desiderio Reyes Suárez
The lung microbiota is a complex community of microorganisms that colonize the respiratory tract of individuals from, or even before, birth. Although the lungs were traditionally believed to be sterile, recent research has shown that there is a diversity of bacterial species in the respiratory system. Knowledge about the lung microbiota in newborns and its relationship with bacterial infections is of vital importance to understand the pathogenesis of respiratory diseases in neonatal patients undergoing mechanical ventilation...
March 1, 2024: Pathogens
https://read.qxmd.com/read/38534675/impact-of-genital-infections-and-antibiotic-use-on-incidence-of-preterm-birth-a-retrospective-observational-study
#5
JOURNAL ARTICLE
Daniela Teodora Marti, Felix Bratosin, Ovidiu Rosca, Roxana Folescu, Cosmin Citu, Adrian Ratiu, Zoran Laurentiu Popa
This study investigates the complex interplay among genital infections, antibiotic usage, and preterm birth. This study aims to identify common genital pathogens associated with preterm births, assess the impact of various antibiotic treatments on pregnancy outcomes, and understand antibiotic resistance patterns among these pathogens. This study included 71 pregnant women who experienced preterm birth and 94 women with genital infections who delivered at term. Various maternal characteristics, medical history, signs and symptoms, gestational weight, gestational age, type of birth, vaginal pH, Nugent scores, and vaginal flora were analyzed...
March 5, 2024: Antibiotics
https://read.qxmd.com/read/38534435/the-bad-father-paternal-role-in-biology-of-pregnancy-and-in-birth-outcome
#6
REVIEW
Stefano Raffaele Giannubilo, Daniela Marzioni, Giovanni Tossetta, Ramona Montironi, Maria Liberata Meccariello, Andrea Ciavattini
Pregnancy is generally studied as a biological interaction between a mother and a fetus; however, the father, with his characteristics, lifestyle, genetics, and living environment, is by no means unrelated to the outcome of pregnancy. The half of the fetal genetic heritage of paternal derivation can be decisive in cases of inherited chromosomal disorders, and can be the result of de novo genetic alterations. In addition to the strictly pathological aspects, paternal genetics may transmit thrombophilic traits that affect the implantation and vascular construction of the feto-placental unit, lead to placenta-mediated diseases such as pre-eclampsia and fetal growth retardation, and contribute to the multifactorial genesis of preterm delivery...
March 3, 2024: Biology
https://read.qxmd.com/read/38534428/probiotics-supplementation-during-pregnancy-can-they-exert-potential-beneficial-effects-against-adverse-pregnancy-outcomes-beyond-gestational-diabetes-mellitus
#7
JOURNAL ARTICLE
Efthymios Poulios, Eleni Pavlidou, Sousana K Papadopoulou, Kalliopi Rempetsioti, Athanasios Migdanis, Maria Mentzelou, Maria Chatzidimitriou, Ioannis Migdanis, Odysseas Androutsos, Constantinos Giaginis
BACKGROUND: Probiotics, as supplements or food ingredients, are considered to exert promising healthy effects when administered in adequate quantity. Probiotics' healthy effects are related with the prevention of many diseases, as well as decreasing symptom severity. Currently, the most available data concerning their potential health effects are associated with metabolic disorders, including gestational diabetes mellitus. There is also clinical evidence supporting that they may exert beneficial effects against diverse adverse pregnancy outcomes...
February 28, 2024: Biology
https://read.qxmd.com/read/38533296/retrospective-comparative-analysis-of-neonatal-mortality-and-morbidity-in-preterm-singleton-and-multiple-births-single-center-experience
#8
JOURNAL ARTICLE
Mohammad Alhasoon, Bader Alqahtani, Mohamad Alreefi, Abdulaziz Homedi, Ghadah Alnami, Saif Alsaif, Kamal Ali
Objective. To compare mortality and major neonatal morbidities between singleton preterm infants and preterm infants of multiple gestations born <33 weeks' gestation. Method. Case-control study of preterm multiples and singletons <33 weeks' born at King Abdul-Aziz Medical City Riyadh (KAMC-R) between January 2017 and December 2020. Out-born infants and infants with lethal congenital abnormalities were excluded from the study. Mortality and major neonatal morbidities including bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), sepsis and surgical necrotizing enterocolitis (NEC) were compared between preterm singletons and multiples...
2024: Global Pediatric Health
https://read.qxmd.com/read/38532618/extended-period-of-ventilation-before-delayed-cord-clamping-augments-left-to-right-shunting-and-decreases-systemic-perfusion-at-birth-in-preterm-lambs
#9
JOURNAL ARTICLE
Joseph J Smolich, Kelly R Kenna, Jonathan P Mynard
Previous studies have suggested that an extended period of ventilation before delayed cord clamping (DCC) augments birth-related rises in pulmonary arterial (PA) blood flow. However, it is unknown whether this greater rise in PA flow is accompanied by increases in left ventricular (LV) output and systemic arterial perfusion or whether it reflects enhanced left-to-right shunting across the ductus arteriosus and/or foramen ovale (FO), with decreased systemic arterial perfusion. Using an established preterm lamb birth transition model, this study compared the effect of a short (∼40 s, n = 11), moderate (∼2 min, n = 11) or extended (∼5 min, n = 12) period of initial mechanical lung ventilation before DCC on flow probe-derived perinatal changes in PA flow, LV output, total systemic arterial blood flow, ductal shunting and FO shunting...
March 26, 2024: Journal of Physiology
https://read.qxmd.com/read/38532124/the-joint-effects-of-prenatal-exposure-to-pm-2-5-constituents-and-reduced-fetal-growth-on-children-s-accelerated-growth-in-the-first-3-years-a-birth-cohort-study
#10
JOURNAL ARTICLE
Shuang Zhou, Tiantian Li, Na Han, Kai Zhang, Gongbo Chen, Yi Zhang, Qin Li, Yuelong Ji, Jue Liu, Hui Wang, Jianlin Hu, Ting Liu, Hein Raat, Yuming Guo, Haijun Wang
BACKGROUND: Prenatal fine particulate matter (PM2.5 ) constituents exposure and reduced fetal growth may be risk factors for accelerated growth in early childhood, an important indicator for lifelong health. OBJECTIVE: The study investigated whether the joint effects are present between PM2.5 constituents and reduced fetal growth. METHODS: The study was embedded in a birth cohort in China, including 5424 mother-child pairs. Prenatal PM2.5 and its constituents' [organic carbon (OC), elementary carbon (EC), ammonium (NH4 + ), nitrate (NO3 - ), and sulfate (SO4 2- )] concentrations were estimated based on maternal residential addresses...
March 26, 2024: Journal of Exposure Science & Environmental Epidemiology
https://read.qxmd.com/read/38531818/inhibition-of-the-endoplasmic-reticulum-stress-associated-ire-1-pathway-alleviates-preterm-birth
#11
JOURNAL ARTICLE
Liyin Qiu, Hui Liu, Shali Chen, Yiting Wu, Jianying Yan
BACKGROUND: Premature birth (PTB) remains a major global health concern due to its association with neonatal morbidity and mortality. The unfolded protein response (UPR) within the endoplasmic reticulum (ER) is tightly regulated by Inositol-requiring enzyme type 1 (IRE-1), a pivotal cellular modulator. This study seeks to elucidate the role of the ER stress (ERS)-related IRE-1 pathway in PTB. METHODS: Human placental trophoblast cells HTR8/Svneo were exposed to the ER-stress inducer tunicamycin (TM)...
March 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38531715/preterm-birth-increases-cerebral-palsy-hazards-in-children-of-mothers-with-chronic-hypertension-in-pregnancy
#12
JOURNAL ARTICLE
Yi-Chien Huang, Hung-Chih Lin, Yu-Tzu Chang, Ming-Luen Tsai, Yu-Chia Chang, Lan-Wan Wang
BACKGROUND: Children of mothers with chronic-hypertension in pregnancy have high rates of preterm-birth (<37 weeks of gestation) and small-for-gestational-age (SGA), both of which are risk factors of cerebral palsy (CP). This study investigated the cumulative risks of CP in children exposed to maternal chronic-hypertension vs. other types of hypertensive-disorders-of-pregnancy (HDP), and whether preterm-birth and SGA potentiate the antenatal impact of chronic-hypertension to increase CP hazards...
March 24, 2024: Pediatrics and Neonatology
https://read.qxmd.com/read/38531673/natural-proliferative-phase-frozen-embryo-transfer-a-new-approach-which-may-facilitate-scheduling-without-hindering-pregnancy-outcomes
#13
JOURNAL ARTICLE
Catarina Mendes Godinho, Sérgio Reis Soares, Sofia Gouveia Nunes, Juan M Mascarós Martínez, Samuel Santos-Ribeiro
STUDY QUESTION: How does a natural proliferative phase (NPP) strategy for frozen embryo transfer (FET) compare with the conventional artificial (AC) and natural (NC) endometrial preparation protocols in terms of live birth rates (LBR)? SUMMARY ANSWER: This study supports the hypothesis that, just as for NC, NPP-FET may be a superior alternative to AC in terms of LBR. WHAT IS KNOWN ALREADY: Although FETs are increasing worldwide, the optimal FET protocol is still largely controversial...
March 26, 2024: Human Reproduction
https://read.qxmd.com/read/38531550/blood-pressure-trends-following-birth-in-infants-born-under-25-weeks-gestational-age-a-retrospective-cohort-study
#14
JOURNAL ARTICLE
Emma Persad, Björn Brindefalk, Alexander Rakow
OBJECTIVE: The aim of our study was to describe postnatal blood pressure (BP) trends and evaluate relevant dynamics and outcomes for a subgroup of extremely preterm (EPT) infants. DESIGN: Retrospective observational cohort study. SETTING: Patients admitted to Karolinska University Hospital Stockholm. PATIENTS: EPT infants born between 22+0 and 24+6 weeks' gestational age (GA) undergoing invasive, continuous BP monitoring through an umbilical arterial catheter...
March 25, 2024: BMJ Paediatrics Open
https://read.qxmd.com/read/38531390/factors-associated-with-maternal-morbidity-among-black-women-in-the-united-states
#15
JOURNAL ARTICLE
Catrine Ibrahim Ibrahim Sous, William Moravec, Emily A DeFranco, Elizabeth Kelly, Robert M Rossi
OBJECTIVE: Non-Hispanic Black people (NHBP) have a 3-fold higher rate of maternal mortality compared to other racial groups. Racial disparities in maternal morbidity are well described however there are substantial differences in cultural, economic, and social determinants of health among racial groups. We sought to study the, at-risk, non-Hispanic Black population as its own cohort to identify factors most associated with severe maternal morbidity (SMM). METHODS: This is a population-based retrospective case control study of all livebirths in the U...
March 26, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38530680/impact-of-asthma-medications-during-pregnancy-on-asthma-exacerbation-maternal-and-neonatal-outcomes
#16
JOURNAL ARTICLE
Sangmin Lee, Erin Hetherington, Richard Leigh, Kaylee Ramage, Amy Metcalfe
BACKGROUND: Asthma affects 5% to 13% of pregnant women, and many require daily pharmacotherapy to achieve asthma control; however, adherence to medication during pregnancy often decreases. OBJECTIVE: To understand the association between the use of or adherence to asthma medication with asthma exacerbation and maternal/neonatal outcomes. METHODS: Using linked population-based administrative databases from Alberta, Canada (2012-2018), pregnant women with asthma were categorized based on asthma medication use 1 year before pregnancy: short-acting β-agonists (SABA), inhaled corticosteroids (ICS), and ICS with long-acting β-agonists (ICS+LABA)...
March 7, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38530261/effect-of-early-vs-late-inguinal-hernia-repair-on-serious-adverse-event-rates-in-preterm-infants-a-randomized-clinical-trial
#17
JOURNAL ARTICLE
Martin L Blakely, Andrea Krzyzaniak, Melvin S Dassinger, Claudia Pedroza, Jorn-Hendrik Weitkamp, Ankush Gosain, Michael Cotten, Susan R Hintz, Henry Rice, Sherry E Courtney, Kevin P Lally, Namasivayam Ambalavanan, Catherine M Bendel, Kim Chi T Bui, Casey Calkins, Nicole M Chandler, Roshni Dasgupta, Jonathan M Davis, Katherine Deans, Daniel A DeUgarte, Jeffrey Gander, Carl-Christian A Jackson, Martin Keszler, Karen Kling, Stephen J Fenton, Kimberley A Fisher, Tyler Hartman, Eunice Y Huang, Saleem Islam, Frances Koch, Shabnam Lainwala, Aaron Lesher, Monica Lopez, Meghna Misra, Jamie Overbey, Brenda Poindexter, Robert Russell, Steven Stylianos, Douglas Y Tamura, Bradley A Yoder, Donald Lucas, Donald Shaul, P Ben Ham, Colleen Fitzpatrick, Kara Calkins, Aaron Garrison, Diomel de la Cruz, Shahab Abdessalam, Charlotte Kvasnovsky, Bradley J Segura, Joel Shilyansky, Lynne M Smith, Jon E Tyson
IMPORTANCE: Inguinal hernia repair in preterm infants is common and is associated with considerable morbidity. Whether the inguinal hernia should be repaired prior to or after discharge from the neonatal intensive care unit is controversial. OBJECTIVE: To evaluate the safety of early vs late surgical repair for preterm infants with an inguinal hernia. DESIGN, SETTING, AND PARTICIPANTS: A multicenter randomized clinical trial including preterm infants with inguinal hernia diagnosed during initial hospitalization was conducted between September 2013 and April 2021 at 39 US hospitals...
March 26, 2024: JAMA
https://read.qxmd.com/read/38529692/prenatal-and-postnatal-exposure-to-antibiotics-and-risk-of-food-allergy-in-the-offspring-a-nationwide-birth-cohort-study-in-south-korea
#18
JOURNAL ARTICLE
Jiyeon Oh, Myeongcheol Lee, Jaeyu Park, Hyeon Jin Kim, Seung Won Lee, Masoud Rahmati, Ai Koyanagi, Lee Smith, Min Seo Kim, Guillermo F López Sánchez, Elena Dragioti, Chanyang Min, Nikolaos G Papadopoulos, Youn Ho Shin, Jae Il Shin, Dong Keon Yon
BACKGROUND: There are only preliminary studies examining the associations of postnatal antibiotic exposure with food allergy in childhood, and the effect of antibiotic exposure in utero has not been resolved. Thus, we aimed to investigate the effect of prenatal and postnatal antibiotic exposure on the risk of food allergy in childhood. METHODS: Using the nationwide birth cohort in South Korea, all 3,163,206 infants (pairing mother; n = 2,322,735) born in South Korea between 2010 and 2017 were included in the analysis...
March 2024: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38529052/effect-of-a-multifaceted-approach-on-perceived-support-among-mothers-of-preterm-infants-a-quasi-experimental-study
#19
JOURNAL ARTICLE
Parisa Mohagheghi, Fatemeh Razavinia, Ahmad Khosravi, Seyedeh Saeedeh Mousavi
INTRODUCTION: Mothers of preterm infants need support to deal with the issues caused by the early birth of their infants. OBJECTIVE: The authors examined the impact of a multifaceted supportive approach on the mothers' perceived support levels. METHODS: The present quasi-experimental study was performed on 143 mother-preterm infant pairs, in two neonatal intensive care units (NICUs) of referral and educational hospitals in Tehran, Iran. The base of developed interventions was known to support system patterns of mothers with preterm infants...
2024: SAGE Open Nursing
https://read.qxmd.com/read/38528861/pre-pregnancy-body-mass-index-gestational-diabetes-mellitus-and-gestational-weight-gain-individual-and-combined-effects-on-fetal-growth
#20
JOURNAL ARTICLE
Yanyu Lyu, Mingming Cui, Lingling Zhang, Guang Zheng, Hanxiao Zuo, Qingyong Xiu, Prakesh S Shah
BACKGROUND: Pre-pregnancy body mass index (BMI), gestational diabetes mellitus (GDM), and gestational weight gain (GWG) are interlinked and may play a complex role in fetal growth. We aimed to examine the relationship between pre-pregnancy BMI, GDM, GWG, and fetal growth outcomes and explore the contribution of GDM and GWG to the relationship between Pre-pregnancy obesity/overweight and large-for-gestational-age (LGA) in a prospective cohort. METHODS: We prospectively recruited women in the first trimester and having one-step GDM screened with a 75-g oral glucose tolerance test between 24 and 28 weeks of gestation ( n  = 802)...
2024: Frontiers in Public Health
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