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https://www.readbyqxmd.com/read/29536431/translational-application-of-measuring-mitochondrial-functions-in-blood-cells-obtained-from-patients-with-acute-poisoning
#1
David H Jang, Utsha G Khatri, Anita Mudan, Jennifer S Love, Shawn Owiredu, David M Eckmann
It is conservatively estimated that 5,000 deaths per year and 20,000 injuries in the USA are due to poisonings caused by chemical exposures (e.g., carbon monoxide, cyanide, hydrogen sulfide, phosphides) that are cellular inhibitors. These chemical agents result in mitochondrial inhibition resulting in cardiac arrest and/or shock. These cellular inhibitors have multi-organ effects, but cardiovascular collapse is the primary cause of death marked by hypotension, lactic acidosis, and cardiac arrest. The mitochondria play a central role in cellular metabolism where oxygen consumption through the electron transport system is tightly coupled to ATP production and regulated by metabolic demands...
March 13, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29526148/utilisation-of-preconception-care-services-and-determinants-of-poor-uptake-among-a-cohort-of-women-in-abakaliki-southeast-nigeria
#2
Napoleon N Ekem, Lucky O Lawani, Robinson C Onoh, Chukwuemeka A Iyoke, Leonard O Ajah, Emeka O Onwe, Azubuike K Onyebuchi, Love C Okafor
Preconception care (PCC) is a preventive strategy for maternal and perinatal morbidity and mortality. This study aimed to assess the level of awareness and utilisation of PCC services. A descriptive cross-sectional survey was conducted at a teaching hospital. Interviewer-administered questionnaires were used to extract information. A total of 450 participants responded; 44.2% (190/450) were aware, 31.7% (143/450) had good knowledge, while only 10.3% (46/450) received PCC. Health care providers were the main source of information (77...
March 12, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29524867/low-intensity-violence-and-the-social-determinants-of-adolescent-health-among-three-east-african-pastoralist-communities
#3
Ivy L Pike, Charles Hilton, Matthias Österle, Owuor Olungah
Recently, strong pleas have emerged to place the health of adolescents on the global health agenda. To reposition adolescence front and center, scholars argue that we must work toward a richly contextualized approach that considers the role that social environments play in shaping the final stages of growth and development. We aim to contribute to this deeper understanding of the social determinants of global adolescent health by offering a case study of three nomadic pastoralist communities from northern Kenya...
April 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29495488/analysis-of-health-behaviors-and-personal-values-of-childless-women-pregnant-women-and-women-who-recently-delivered
#4
Grzegorz Józef Nowicki, Patrycja Misztal-Okońska, Barbara Ślusarska, Ewa Rudnicka-Drożak, Magdalena Młynarska, Artur Czekierdowski
Preconception lifestyle modifications and reduction of several known risk factors may have an influence on future pregnancy outcomes. The aim of the study was to analyze health behaviors and personal values as well as to assess the relationship between these factors in women without children, in pregnant women and in women who had already delivered babies. The questionnaire survey included the Health Behavior Inventory (HBI), the Personal Value List (PVL) and sociodemographic data and was conducted in 538 women...
February 27, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29482525/internet-based-grief-therapy-for-bereaved-individuals-after-loss-due-to-haematological-cancer-study-protocol-of-a-randomized-controlled-trial
#5
Rahel Hoffmann, Julia Große, Michaela Nagl, Dietger Niederwieser, Anja Mehnert, Anette Kersting
BACKGROUND: Approximately 10% of the individuals experiencing the death of a loved one develop prolonged grief disorder (PGD) after bereavement. Family members of haematological cancer patients might be particularly burdened since their loss experience is preceded by a very strenuous time of disease and aggressive treatment. However, support needs of relatives of cancer patients often remain unmet, also after the death of the patient. Therapeutic possibilities are enhanced by providing easily available and accessible Internet-based therapies...
February 27, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29438560/hiite-hiv-1-incidence-and-infection-time-estimator
#6
Sung Yong Park, Tanzy M T Love, Shivankur Kapoor, Ha Youn Lee, John Hancock
Motivation: Around 2.1 million new HIV-1 infections were reported in 2015, alerting that the HIV-1 epidemic remains a significant global health challenge. Precise incidence assessment strengthens epidemic monitoring efforts and guides strategy optimization for prevention programs. Estimating the onset time of HIV-1 infection can facilitate optimal clinical management and identify key populations largely responsible for epidemic spread and thereby infer HIV-1 transmission chains. Our goal is to develop a genomic assay estimating the incidence and infection time in a single cross-sectional survey setting...
February 9, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29432396/gathering-tips-from-carers-to-support-people-with-dementia-an-adaptation-of-the-top-5-program-for-community-use
#7
Kerrie Westaway, Oliver Frank, Russell Shute, Anna Moffat, Vanessa LeBlanc, Debra Rowett, Natalie Blacker, Elizabeth Roughead
AIM: Behavioral and psychological symptoms of dementia are often managed inappropriately with antipsychotic medicines. The TOP 5 program, which involves recording up to five relevant and meaningful tips that assist in personalizing care for the person with dementia, has been tested in the hospital setting and transitions of care in Australia, and has been found to be useful. Our study aimed to adapt the TOP 5 program as a strategy to support people with dementia in a primary care setting and to test the acceptability of our adapted TOP 5 program materials...
February 9, 2018: International Journal of Evidence-based Healthcare
https://www.readbyqxmd.com/read/29397383/facilitating-factors-of-self-care-among-hiv-positive-young-women-in-iran-a-qualitative-study
#8
Fatemeh Oskouie, Farzaneh Kashefi, Forough Rafii, Mohammad Mehdi Gouya, Marzieh Vahid-Dastjerdi
Background Providing care for chronic disease such as HIV is a growing challenge in the world. In order to address the challenges of linkage and care in chronic disease management, we need to identify factors that can influence people to get more involved in self-care. This study was part of an extensive qualitative study conducted in Tehran, Iran in 2016. Methods The data were collected through semi-structured interviews conducted on 25 women with HIV, and were analyzed using grounded theory. Four main themes were identified as facilitating self-care among participants: health system support, clinicians' support, family support and improved life expectancy...
February 5, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29229011/making-sense-of-loss-through-spirituality-perspectives-of-african-american-family-members-who-have-experienced-the-death-of-a-close-family-member-to-cancer
#9
Jill B Hamilton, Nakia C Best, Jessica S Wells, Valarie C Worthy
OBJECTIVE: Among African Americans, spirituality is meaning or purpose in life and a faith in God who is in control of health and there to provide support and guidance in illness situations. Using qualitative methods, we explored the use of spirituality to make sense of the end-of-life and bereavement experiences among family members of a deceased cancer patient. METHOD: Data in this report come from 19 African Americans who experienced the loss of a family member to cancer...
December 12, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29180054/-a-therapeutic-education-program-for-parents-of-children-with-asd-preliminary-results-about-the-effectiveness-of-the-etap-program
#10
C Derguy, M Poumeyreau, S Pingault, K M'bailara
Autism Spectrum Disorders (ASD) are characterized by particularities of cognitive and socio-adaptive functioning. Daily, they require specific interventions for the disabled person as well as support for parents who often report deterioration in their physical and mental health. To this end, the latest Autism Plan 2013-2017 highlights the need "to help families to be present and active alongside their loved ones, to avoid situations of exhaustion and stress and to enable them to play their role fully in the long term"...
November 24, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29170758/design-and-rationale-for-a-technology-based-healthy-lifestyle-intervention-in-older-adults-grieving-the-loss-of-a-spouse
#11
Sarah T Stahl, James Emanuel, Steven M Albert, Mary Amanda Dew, Richard Schulz, Gregg Robbins-Welty, Charles F Reynolds
Introduction: Experiencing the death of a spouse during late life is associated with an increased risk of developing debilitating mental health problems. Healthy lifestyle practices, such as regular exercise, healthy eating, and good sleep hygiene are promising strategies to influence the mental health and associated physical symptoms of late-life spousal bereavement. Objective: This paper describes the design and rationale of an intervention development study addressing selective and indicated prevention of depression, anxiety, and/or complicated grief disorder(s) among adults 60 years and older who are grieving the recent loss (within 8 months) of a spouse or partner...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29141482/obstetric-practice-guidelines-labor-s-love-lost
#12
Wayne R Cohen, Emanuel A Friedman
Implementation of clinical practice guidelines may moderate health care costs, improve care, reduce medicolegal liability, and provide a uniformity in care allowing meaningful investigation of treatments and outcomes. However, new guidelines are often uncritically embraced by clinicians, risk management organizations, insurance companies, and the courts as the standard of care. Adoption of incompletely vetted recommendations can lead to patient harm. Recent recommendations made by the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine for assessment and management of labor provide an example of well-intended guidelines adopted uncritically...
January 31, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29102557/textual-analysis-of-general-surgery-residency-personal-statements-topics-and-gender-differences
#13
Laura Ostapenko, Cheryl Schonhardt-Bailey, Jessica Walling Sublette, Douglas S Smink, Nora Y Osman
PURPOSE: Applicants to US general surgery residency training programs submit standardized applications. Applicants use the personal statement to express their individual rationale for a career in surgery. Our research explores common topics and gender differences within the personal statements of general surgery applicants. METHODS: We analyzed the electronic residency application service personal statements of 578 applicants (containing 3,82,405 words) from Liaison Committee on Medical Education-accredited medical schools to a single ACGME-accredited general surgery program using an automated textual analysis program to identify common topics and gender differences...
October 25, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29072233/effects-of-parental-attitudes-on-the-use-of-addictive-substances-in-high-school-students
#14
C Öztekin, T Şengezer, A Özkara
BACKGROUND: Substance abuse is a major public health problem including social and economic aspects. Although multidimensional data about substance abuse are limited in our country, the fact that Turkey is located at the crossroads of Europe and Asia with a young population creating a promising market brings out the necessity of maintaining high awareness on substance abuse. Smoking, alcohol, and substance use are important health problems of adolescence period and families play a major role on adaptation to the changes in growth and development period...
September 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29072148/patient-family-eol-communication-and-its-predictors-reports-from-caregivers-of-latino-patients-in-the-rural-u-s-mexico-border-region
#15
Eunjeong Ko, Jaehoon Lee, Carlos Ramirez, Denicka Lopez, Stephanie Martinez
OBJECTIVE: Family caregivers play an important role in end-of-life (EoL) decision making when the patient is unable to make his/her own decisions. While communication about EoL care between patients and family is perhaps a first step toward advance care planning (ACP)/EoL decisions, not every culture puts great value on open communication about this topic. The aims of the present study were to explore EoL communication and the aspects of communication among caregivers of Latino patients in the rural United States (U...
October 26, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28976401/-sexual-life-in-elderly-patients-with-cardiovascular-disease
#16
Hakan Karpuz
Sexual activity is an important component of patient and partner quality of life for men and women with cardiovascular disease, including many elderly patients. Older adults desire sexual intimacy when there is a partner and a health status that allows sexual relationships. Older individuals desire to love and enjoy sexual activity in relation to personal circumstances, and when health status allows them to experience close relations, most often within marriage especially in our country. Normal changes occur in the phases of sexual cycle with aging, male erectile dysfunction and female sexual dysfunction increase with age...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28966794/analysis-of-il-6-il-1%C3%AE-and-tnf-%C3%AE-production-in-monocytes-isolated-from-multiple-sclerosis-patients-treated-with-disease-modifying-drugs
#17
Sarah E Fiedler, Joshua D George, Haley N Love, Edward Kim, Rebecca Spain, Dennis Bourdette, Sonemany Salinthone
OBJECTIVE AND DESIGN: The etiology of multiple sclerosis (MS) is unknown, but blood derived monocytes/macrophages are believed to be involved in the pathogenesis through phagocytosis of myelin and production of inflammatory mediators. The objective of this study is to examine inflammatory cytokines that are present at elevated levels in active MS lesions to determine whether there are differences between classically stimulated monocytes isolated from healthy control (HC) and relapsing-remitting MS (RRMS) subjects taking disease modifying drugs (DMDs), including dimethyl fumarate (DMF)...
May 2017: Journal of Systems and Integrative Neuroscience
https://www.readbyqxmd.com/read/28953810/-a-labour-of-love-a-king-s-college-london-psychiatry-society-event-to-challenge-the-stigma-attached-to-mental-health-problems-in-post-natal-women
#18
Ahmed Hankir, Phillipa Brothwood, Bethany Crocker, Mao Fong Lim, Isabel Lever, Frederick Carrick, Rashid Zaman, Charlotte Wilson Jones
BACKGROUND: On the 9th October 2000, Dr Daksha Emson, a London based psychiatrist with bipolar affective disorder, tragically killed herself and her three-month-old baby daughter during a psychotic episode. An independent inquiry into Dr Emson's death concluded that mental health stigma in the National Health Service was a factor that contributed to her death. Despite the morbidity and mortality attributed to the stigma attached to post-natal mental health problems there are very few programmes that have been developed to challenge it...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28916405/love-death-a-retrospective-and-prospective-follow-up-mortality-study-over-45-years
#19
Lena Lange, Barbara Zedler, Marcel A Verhoff, Markus Parzeller
BACKGROUND: Although sexual activity can cause moderate stress, it can cause natural death in individuals with pre-existing illness. The aim of this study was to identify additional pre-existing health problems, sexual practices, and potential circumstances that may trigger fatal events. METHODS: This medicolegal postmortem, retrospective, and prospective study is based on data of autopsies performed at the Institute of Legal Medicine of the University hospital, Goethe-University, Frankfurt/Main, Germany...
October 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28905680/roma-never-die-alone
#20
Tania Garcia-Espinel, Laura Aso, Gisela Redondo-Sama, Ainhoa Flecha
A common characteristic of Roma as a cultural group is that they do not allow their elderly to die alone. Nevertheless, rooted in a mainstream cultural perspective of health provision services, public institutions usually do not allow Roma people to be with their loved ones in their last moments. Following the communicative methodology, we conducted a communicative case study on the death of the most relevant female Roma leader in Catalonia. She was accompanied by more than two hundred family members and friends in her room and corridor at an important hospital in Barcelona...
September 1, 2017: Qualitative Health Research
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