Claudio Pisano, Graziella Pratesi, Diletta Laccabue, Franco Zunino, Pietro Lo Giudice, Augusta Bellucci, Licia Pacifici, Barbara Camerini, Loredana Vesci, Massimo Castorina, Sandra Cicuzza, Giovanni Tredici, Paola Marmiroli, Gabriella Nicolini, Stefania Galbiati, Menotti Calvani, Paolo Carminati, Guido Cavaletti
PURPOSE: Antineoplastic drugs belonging to platinum or taxane families are severely neurotoxic, inducing the onset of disabling peripheral neuropathies with different clinical signs. Acetyl-L-carnitine (ALC) is a natural occurring compound with a neuroprotective activity in several experimental paradigms. In this study we have tested the hypothesis that ALC may have a protective role on cisplatin and paclitaxel-induced neuropathy. EXPERIMENTAL DESIGN: Sensory nerve conduction velocity (SNCV) was measured in rats before, at end, and after an additional follow-up period from treatments with cisplatin, paclitaxel, or with the respective combination with ALC...
November 15, 2003: Clinical Cancer Research