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Depression impairment

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https://www.readbyqxmd.com/read/29923530/a-study-on-prevalence-of-depression-and-associated-risk-factors-among-elderly-in-a-rural-block-of-tamil-nadu
#1
M Buvneshkumar, K R John, M Logaraj
Background: Depression among elderly is an important public health problem responsible for considerable morbidity and disability. Causes of depression are multifactorial and often preventable. As there was dearth of community studies in Tamil Nadu, the present study was undertaken. Objectives: The objective of this study is to estimate the prevalence of depression and to assess the factors which are associated with depression among elderly. Methods: A cross-sectional study was done from July 2014 to July 2015 among elderly in Kattankulathur block with a sample size of 690 by cluster sampling method...
April 2018: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29923072/symptomatic-and-functional-recovery-in-depression-in-later-life
#2
Rose M Collard, Sanne Wassink-Vossen, Aart H Schene, Paul Naarding, Peter Verhaak, Richard C Oude Voshaar, Hannie C Comijs
OBJECTIVES: Functional limitations give an indication of the total impact of diseases, such as depression, on individuals health and recovery. This study examines the change in several domains of functioning over 2 years in older persons depressed at baseline (non-remitted group and remitted group after 2 years) and in a non-depressed comparison group. METHODS: Data were used from a cohort study (Netherlands Study of Depression in Older persons [NESDO]) consisting of depressed older persons ≥ 60 years (N = 378) and a non-depressed comparison group (N = 132) with 2 years of follow-up (attrition rate 24%)...
June 19, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29922522/delayed-post-hypoxic-leukoencephalopathy-a-case-series-and-review-of-the-literature
#3
Nakul Katyal, Naureen Narula, Pravin George, Premkumar Nattanamai, Christopher R Newey, Jonathan M Beary
Delayed post-hypoxic leukoencephalopathy (DPHL) is a unique clinical entity that presents with cognitive impairment days to weeks after an episode of acute hypoxic brain injury. Frequently hypoxia is unrecognized as a mechanism for clinical decline and extensive workup ensues. We present two cases of DPHL highlighting the neuroimaging findings. In both patients, a cerebral hypoxic event was followed by a recovery phase with subsequent delayed clinical decline. Patient 1 suffered hypoxia from drug-induced respiratory depression and lack of post-operative positive airway pressure (PAP) support...
April 15, 2018: Curēus
https://www.readbyqxmd.com/read/29922224/neuroendocrine-abnormalities-following-traumatic-brain-injury-an-important-contributor-to-neuropsychiatric-sequelae
#4
REVIEW
Amir M Molaie, Jamie Maguire
Neuropsychiatric symptoms following traumatic brain injury (TBI) are common and contribute negatively to TBI outcomes by reducing overall quality of life. The development of neurobehavioral sequelae, such as concentration deficits, depression, anxiety, fatigue, and loss of emotional well-being has historically been attributed to an ambiguous "post-concussive syndrome," considered secondary to frank structural injury and axonal damage. However, recent research suggests that neuroendocrine dysfunction, specifically hypopituitarism, plays an important role in the etiology of these symptoms...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29922222/cognitive-deficits-are-attenuated-in-neuroglobin-overexpressing-mice-exposed-to-a-model-of-obstructive-sleep-apnea
#5
Deepti Nair, Vijay Ramesh, David Gozal
Background: Obstructive sleep apnea (OSA) is a highly prevalent disease manifesting as intermittent hypoxia during sleep (IH) and is increasingly recognized as being independently associated with neurobehavioral deficits. These deficits may be due to increased apoptosis in the hippocampus and cerebral cortex, as well as increased oxidative stress and inflammation. It has been reported that neuroglobin (Ngb) is upregulated in response to hypoxia-ischemia insults and exhibits a protective role in ischemia-reperfusion brain injury...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29922189/aberrant-neural-activity-in-patients-with-bipolar-depressive-disorder-distinguishing-to-the-unipolar-depressive-disorder-a-resting-state-functional-magnetic-resonance-imaging-study
#6
Meihui Qiu, Huifeng Zhang, David Mellor, Jun Shi, Chuangxin Wu, Yueqi Huang, Jianye Zhang, Ting Shen, Daihui Peng
This study aims to explore the intrinsic patterns of spontaneous activity of bipolar depression (BD) patients by analyzing the fractional amplitude of low frequency fluctuation (fALFF) that help differentiate BD from unipolar depressive disorder(UD). Twenty eight patients with BD, 47 patients with UD and 29 healthy controls were enrolled to receive the resting-state functional magnetic resonance imaging (rs-fMRI) scans. The group differences of fALFF values were calculated among three groups. In addition, the correlations between the clinical variables and mfALFF values were estimated...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29922049/sarcopenic-obesity-and-cognitive-performance
#7
Magdalena I Tolea, Stephanie Chrisphonte, James E Galvin
Background: Sarcopenia and obesity both negatively impact health including cognitive function. Their coexistence, however, can pose an even higher threat likely surpassing their individual effects. We assessed the relationship of sarcopenic obesity with performance on global- and subdomain-specific tests of cognition. Patients and methods: The study was a cross-sectional analysis of data from a series of community-based aging and memory studies. The sample consisted of a total of 353 participants with an average age of 69 years with a clinic visit and valid cognitive (eg, Montreal Cognitive Assessment, animal naming), functional (eg, grip strength, chair stands), and body composition (eg, muscle mass, body mass index, percent body fat) measurements...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29921614/peptidoglycan-induces-disseminated-intravascular-coagulation-in-baboons-through-activation-of-both-coagulation-pathways
#8
Narcis I Popescu, Robert Silasi, Ravi S Keshari, Alanson Girton, Tarea Burgett, Sacha S Zeerleder, David Gailani, Andras Gruber, Florea Lupu, K Mark Coggeshall
Anthrax infections exhibit progressive coagulopathies that may contribute to the sepsis pathophysiology observed in fulminant disease. The hemostatic imbalance is recapitulated in primate models of late-stage disease but is uncommon in toxemic models suggesting contribution of other bacterial pathogen associated molecular patterns (PAMPs). Peptidoglycan (PGN) is a bacterial PAMP that engages cellular components at the crosstalk between innate immunity and hemostasis. We hypothesized that PGN is critical for anthrax-induced coagulopathies and investigated the activation of blood coagulation in response to a sterile PGN infusion in primates...
June 19, 2018: Blood
https://www.readbyqxmd.com/read/29921540/poor-nutritional-status-among-low-income-older-adults-examining-the-interconnection-between-self-care-capacity-food-insecurity-and-depression
#9
Seung Eun Jung, Seoyoun Kim, Alex Bishop, Janice Hermann
BACKGROUND: Understanding of the mechanisms of how food insecurity and poor physical and mental health status are interrelated with nutritional status among older adults is needed due to their unique health and social needs. OBJECTIVE: To examine the complex relationships between self-care capacity, depressive symptoms, food insecurity, and nutritional status among low-income older adults. DESIGN: The cross-sectional study was conducted from February 2017 to May 2017...
June 16, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29921145/the-burden-of-bereavement-early-onset-depression-and-impairment-in-youths-bereaved-by-sudden-parental-death-in-a-7-year-prospective-study
#10
Steven Pham, Giovanna Porta, Candice Biernesser, Monica Walker Payne, Satish Iyengar, Nadine Melhem, David A Brent
OBJECTIVE: The authors sought to determine the long-term impact of sudden parental death on youths and pathways between youth bereavement and impairment. METHODS: Youths (N=216) who lost a parent to suicide, accident, or sudden natural death and nonbereaved youths (N=172) were followed periodically for up to 7 years. The incidence and prevalence of disorder and of functional impairment, as well as pathways to impairment, were assessed using Cox and mixed-effects logistic regression and structural equation modeling...
June 20, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29921144/a-randomized-controlled-trial-of-parent-child-psychotherapy-targeting-emotion-development-for-early-childhood-depression
#11
Joan L Luby, Deanna M Barch, Diana Whalen, Rebecca Tillman, Kenneth E Freedland
OBJECTIVE: Clinical depression in children as young as age 3 has been validated, and prevalence rates are similar to the school-age disorder. Homotypic continuity between early and later childhood depression has been observed, with alterations in brain function and structure similar to those reported in depressed adults. These findings highlight the importance of identifying and treating depression as early as developmentally possible, given the relative treatment resistance and small effect sizes for treatments later in life...
June 20, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29920978/effects-of-intrinsic-factors-on-the-clinical-pharmacokinetics-of-vortioxetine
#12
Grace Chen, George G Nomikos, John Affinito, William Jacobson, Zhen Zhao, Shining Wang, Jinhui Xie
Vortioxetine is an antidepressant agent with multimodal activity that is approved for the treatment of major depressive disorder at doses of 5 to 20 mg once daily. Vortioxetine is a medium-clearance drug that undergoes extensive metabolism via several cytochrome P450 isozymes. A series of single- and multiple-dose pharmacokinetic studies were performed to evaluate the impact of intrinsic (ie, subject-related) factors, such as age, sex, race, and renal and hepatic function, on the pharmacokinetics of vortioxetine...
June 19, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29920297/resting-frontal-brain-asymmetry-is-linked-to-future-depressive-symptoms-in-women
#13
Jennifer L Stewart, John J B Allen
This longitudinal pilot study examined whether baseline resting frontal electroencephalographic (EEG) asymmetry correlates with depressive symptoms during the most impaired two-week period in the following year. Current-source-density (CSD) transformed resting frontal EEG asymmetry, severity of depression symptoms (Beck Depression Inventory - II), and stress (indexed by negative life events; NLE) were recorded in never-depressed young adults with no current DSM-IV diagnosis (38 women, 16 men) at baseline. One year later, depression symptoms and NLEs experienced during the interim were assessed...
June 16, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29920178/risk-factors-for-depression-in-long-term-care-a-systematic-review
#14
Rebecca Chau, David W Kissane, Tanya E Davison
OBJECTIVES: Depression rates are substantially higher among older adults in long-term care compared to older adults in the community. Furthermore, the needs of older adults in long-term care are increasingly complex, and risk factors that contribute to depression in this population are unclear. This limits not only the identification of those at risk of depression but the development of therapeutic interventions. This review summarises the evidence on risk factors for depression. METHODS: Searches were performed using CINAHL, Cochrane Library, Ovid Medline, PsycINFO and Scopus for research published 1980-2017...
June 19, 2018: Clinical Gerontologist
https://www.readbyqxmd.com/read/29919988/amygdala-and-emotionality-in-parkinson-s-disease-an-integrative-review-of-the-neuropsychological-evidence
#15
(no author information available yet)
Parkinson\'s disease (PD) is often accompanied by significant changes in emotionality, such as apathy, anhedonia, anxiety and depression. The present review summarizes the empirical evidence, including amygdala changes and psychological changes in emotionality in people suffering with PD. Seventeen empirical full-text articles including research on both amygdala and emotionality in PD were reviewed.The changes in amygdala volumes as well as changes in binding potentials, functional connectivity, regional homogeneity and regional cerebral blood flow were found to have various impacts on emotionality in people with PD...
May 19, 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29917056/sustained-activation-of-postsynaptic-5-ht2a-receptors-gates-plasticity-at-prefrontal-cortex-synapses
#16
Coralie Berthoux, Alexander Barre, Joël Bockaert, Philippe Marin, Carine Bécamel
The prefrontal cortex (PFC) plays a key role in many high-level cognitive processes. It is densely innervated by serotonergic neurons originating from the dorsal and median raphe nuclei, which profoundly influence PFC activity. Among the 5-HT receptors abundantly expressed in PFC, 5-HT2A receptors located in dendrites of layer V pyramidal neurons control neuronal excitability and mediate the psychotropic effects of psychedelic hallucinogens, but their impact on glutamatergic transmission and synaptic plasticity remains poorly characterized...
June 16, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29916889/a-new-technique-in-management-of-depressed-posttracheostomy-scars
#17
Sevgi Kurt Yazar, Erkan Yüce, Merdan Serin, Memet Yazar, Zeliha Gül, Fatih Irmak, Serhat Selami Şirvan
BACKGROUND: The goals of tracheostomy scar revision are filling of the depressed area, providing easy sliding of skin over the trachea. There are various techniques described to correct this situation. In this article, a modification of split sternocleidomastoid (SCM) muscle flap used in the correction of posttracheostomy defects is described. METHODS: Thirteen patients who had depressed scars after tracheostomy are included in this study. The mean patient age was 44 years (range, 27-56 years)...
June 19, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29916565/-care-related-intervention-in-rehabilitative-pneumology-pulmonary-rehabilitation-in-chronic-obstructive-broncopneumopathies-copd-can-benefit-from-a-multidisciplinary-approach
#18
Michele Vitacca, Dina Visca, Antonio Spanevello
OBJECTIVES: Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation. Cardiovascular diseases, osteoporosis, depression/anxiety, musculoskeletal impairment and obstructive sleep apnea are frequent and important comorbidities in COPD, often under-diagnosed, and associated with poor health status and prognosis. METHODS: Pulmonary rehabilitation improves symptoms, quality of life, pulmonary function, and health care in patients with chronic respiratory disease...
February 2018: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29915770/frontal-meningioma-with-psychiatric-symptoms
#19
Suria Hussin, Siti Suhaila Mohd Yusoff, Faridah Mohd Zin, Ab Rahman Izaini Ghani
Frontal meningioma is often asymptomatic and patient may present with psychiatric symptoms. We report a case of 45- year-old female patient with no premorbid medical illness presented with 6 months history of depressive symptoms and changes in personality. Her worsening cognitive impairment brought her to psychiatry clinic and led to further investigation with contrast-enhanced computed tomography (CECT) Brain. The result showed well defined markedly enhancing lesion in the frontal region measuring 5.5 cm X5...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915554/full-spectrum-of-reported-symptoms-of-bilateral-vestibulopathy-needs-further-investigation-a-systematic-review
#20
Florence Lucieer, Stijn Duijn, Vincent Van Rompaey, Angelica Pérez Fornos, Nils Guinand, Jean Philippe Guyot, Herman Kingma, Raymond van de Berg
Objective: To systematically review the symptoms reported by patients with bilateral vestibulopathy (BV) in clinical studies and case reports. This would serve as the first step in establishing a validated patient-reported outcome measures (PROM) for BV. Methods: A search on symptoms reported by patients with BV was performed in PubMed, and all publications covering these symptoms were included. Exclusion criteria comprised reviews and insufficient details about the frequency of occurrence of symptoms...
2018: Frontiers in Neurology
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