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Depression impairment

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https://www.readbyqxmd.com/read/29689718/subjective-cognitive-decline-objective-cognition-and-depression-in-older-hispanics-screened-for-memory-impairment
#1
Zvinka Z Zlatar, Martha C Muniz, Sarah Espinoza, Roberto Gratianne, Tamar H Gollan, Douglas Galasko, David P Salmon
Subjective cognitive decline (SCD) is common in older adults and may be an early marker of future cognitive decline. Research suggest that SCD is more closely related to concurrent symptoms of depression than to objective cognitive performance in non-Hispanic Whites, but it is unknown whether the associations of SCD, cognition, and depression manifest differently in Hispanic older adults. We examined if SCD is associated with objective cognitive performance or with depression symptoms in 145 Hispanic individuals ages 60 or older referred by community health clinics for screening of cognitive complaints...
April 14, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29689582/-late-life-depression-diagnosis-pathophysiology-and-therapeutic-strategies
#2
Forugh S Dafsari, Frank Jessen
Late-life depression is a frequent and severe mental disorder. It is characterized by alterations in mood as well as cognitive deficits and somatic symptoms. LLD is associated with various adverse outcomes, such as reduced quality of life, negative impact on physical comorbidities, functional impairments, increased suicide and non-suicide mortality. Moreover, LLD serves as a risk factor for developing all-cause dementia, including Alzheimer´s disease. It leads to a frequent use of health care services and remains a serious public health concern...
April 2018: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29689500/neural-correlates-of-top-down-regulation-and-generation-of-negative-affect-in-major-depressive-disorder
#3
Elena Goetz Davis, Lara C Foland-Ross, Ian H Gotlib
Major depressive disorder (MDD) is characterized by biased information processing that leads to difficulties regulating negative affect, which includes difficulty decreasing negative affect as well as maladaptively increasing negative affect via cognitive processes. To examine the underlying neural correlates, we scanned depressed and never-depressed adults as they completed a cognitive reappraisal task which required decreasing negative affect while viewing a negative image (down-regulation) and increasing negative affect while viewing a neutral image (emotion generation)...
April 7, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29689442/ameliorating-mitochondrial-dysfunction-restores-carbon-ion-induced-cognitive-deficits-via-co-activation-of-nrf2-and-pink1-signaling-pathway
#4
Yang Liu, Jiawei Yan, Cao Sun, Guo Li, Sirui Li, Luwei Zhang, Cuixia Di, Lu Gan, Yupei Wang, Rong Zhou, Jing Si, Hong Zhang
Carbon ion therapy is a promising modality in radiotherapy to treat tumors, however, a potential risk of induction of late normal tissue damage should still be investigated and protected. The aim of the present study was to explore the long-term cognitive deficits provoked by a high-linear energy transfer (high-LET) carbon ions in mice by targeting to hippocampus which plays a crucial role in memory and learning. Our data showed that, one month after 4 Gy carbon ion exposure, carbon ion irradiation conspicuously resulted in the impaired cognitive performance, neurodegeneration and neuronal cell death, as well as the reduced mitochondrial integrity, the disrupted activities of tricarboxylic acid cycle flux and electron transport chain, and the depressed antioxidant defense system, consequently leading to a decline of ATP production and persistent oxidative damage in the hippocampus region...
April 14, 2018: Redox Biology
https://www.readbyqxmd.com/read/29689055/does-a-patient-s-health-potential-affect-the-social-valuation-of-health-services
#5
Jeff Richardson, Angelo Iezzi, Aimee Maxwell
BACKGROUND: Patients with a permanent impairment may be unable to reach full health. Consequently health services which cure illnesses which are unrelated to the impairment may increase health less than services for patients with no impairment. While it has been argued that this should not lead to discrimination against impaired patients there is little evidence to determine whether this equity-efficiency trade-off is consistent with social values. OBJECTIVES: To measure the effect of permanent impairment upon the social valuation of services for unrelated illnesses...
2018: PloS One
https://www.readbyqxmd.com/read/29688389/modulation-of-gsk-3%C3%AE-%C3%AE-catenin-signaling-contributes-to-learning-and-memory-impairment-in-a-rat-model-of-depression
#6
Jiaojie Hui, Jianping Zhang, Mengjia Pu, Xingliang Zhou, Liang Dong, Xuqiang Mao, Guofeng Shi, Jian Zou, Jingjing Wu, Dongmei Jiang, Guangjun Xi
Background: It is widely accepted that cognitive processes, such as learning and memory, are affected in depression, but the molecular mechanisms underlying the interactions of these 2 disorders are not clearly understood. Recently, glycogen synthase kinase-3 beta (GSK-3β)/β-catenin signaling was shown to play an important role in the regulation of learning and memory. Methods: The present study used a rat model of depression, chronic unpredictable stress, to determine whether hippocampal GSK-3β/β-catenin signaling was involved in learning and memory alterations...
April 23, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29687328/determinants-of-quality-of-life-and-psychological-status-in-adults-with-psoriasis
#7
Zhenli Kwan, Yii Bonn Bong, Leng Leng Tan, Shu Xian Lim, Adrian Sze Wai Yong, Chin Chwen Ch'ng, Maw Pin Tan, Rokiah Ismail
We investigated whether disease severity and clinical manifestations were associated with depression, anxiety, stress and quality of life in adults with psoriasis. Participants were recruited from a dermatology outpatient clinic at a teaching hospital. Information on sociodemographic characteristics, disease severity, presence of arthropathy and head involvement was specifically recorded. Disease severity was assessed using the Psoriasis Area and Severity Index (PASI). Quality of life and psychological symptoms were measured using the Dermatology Life Quality Index (DLQI) and the Depression Anxiety Stress Scale (DASS), respectively...
April 23, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29686643/inhibition-of-mtorc1-signaling-reverts-cognitive-and-affective-deficits-in-a-mouse-model-of-parkinson-s-disease
#8
Débora Masini, Alessandra Bonito-Oliva, Maëlle Bertho, Gilberto Fisone
Non-motor symptoms, including cognitive deficits and affective disorders, are frequently diagnosed in Parkinson's disease (PD) patients and are only partially alleviated by dopamine replacement therapy. Here, we used a 6-hydroxydopamine (6-OHDA) mouse model of PD to examine the effects exerted on non-motor symptoms by inhibition of the mammalian target of rapamycin complex 1 (mTORC1), which is involved in the control of protein synthesis, cell growth, and metabolism. We show that rapamycin, which acts as an allosteric inhibitor of mTORC1, counteracts the impairment of novel object recognition...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29686630/visual-impairment-is-associated-with-depressive-symptoms-results-from-the-nationwide-german-degs1-study
#9
Alexander K Schuster, Jonas Tesarz, Jasmin Rezapour, Manfred E Beutel, Bernd Bertram, Norbert Pfeiffer
Introduction: Visual impairment (VI) is associated with a variety of comorbidities including physical and mental health in industrial countries. Our aim is to examine associations between self-reported impairment and depressive symptoms in the German population. Methods: The point prevalence of self-reported VI in Germany was computed using data from the German Health Interview and Examination Survey for adults from 2008 to 2011 ( N  = 7.783, 50.5% female, age range 18-79 years)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29685870/effectiveness-of-an-internet-and-app-based-intervention-for-college-students-with-elevated-stress-randomized-controlled-trial
#10
Mathias Harrer, Sophia Helen Adam, Rebecca Jessica Fleischmann, Harald Baumeister, Randy Auerbach, Ronny Bruffaerts, Pim Cuijpers, Ronald C Kessler, Matthias Berking, Dirk Lehr, David Daniel Ebert
BACKGROUND: Mental health problems are highly prevalent among college students. Most students with poor mental health, however, do not receive professional help. Internet-based self-help formats may increase the utilization of treatment. OBJECTIVE: The aim of this randomized controlled trial was to evaluate the efficacy of an internet-based, app-supported stress management intervention for college students. METHODS: College students (n=150) with elevated levels of stress (Perceived Stress Scale 4-item version, PSS-4 ≥8) were randomly assigned to either an internet- and mobile-based stress intervention group with feedback on demand or a waitlist control group...
April 23, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29684613/low-or-excess-levels-of-dietary-cholesterol-impaired-immunity-and-aggravated-inflammation-response-in-young-grass-carp-ctenopharyngodon-idella
#11
Xiao-Zhong Wang, Wei-Dan Jiang, Lin Feng, Pei Wu, Yang Liu, Yun-Yun Zeng, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Xiao-Qiu Zhou
The present study explored the effect of cholesterol on the immunity and inflammation response in the immune organs (head kidney, spleen and skin) of young grass carp (Ctenopharyngodon idella) fed graded levels of dietary cholesterol (0.041-1.526%) for 60 days and then infected with Aeromonas hydrophila for 14 days. The results showed that low levels of cholesterol (1) depressed the innate immune components [lysozyme (LZ), acid phosphatase (ACP), complements and antimicrobial peptides] and adaptive immune component [immunoglobulin M (IgM)], (2) up-regulated the mRNA levels of pro-inflammatory cytokines [interleukin 1β (IL-1β), IL-6, IL-8, IL-12p35, IL-12p40, IL-15, IL-17D, tumor necrosis factor α (TNF-α) and interferon γ2 (IFN-γ2)], partly due to the activated nuclear factor kappa B (NF-κB) signalling, and (3) down-regulated the mRNA levels of anti-inflammatory cytokines [IL-4/13B, IL-10, IL-11, transforming growth factor (TGF)-β1 and TGF-β2], partly due to the suppression of target of rapamycin (TOR) signalling in the immune organs of young grass carp...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684438/the-cytoskeleton-in-couch-potato-ism-insights-from-a-murine-model-of-impaired-actin-dynamics
#12
Karen Gertz, Ria Uhlemann, Anna Foryst-Ludwig, Ruben Marquina Barrientos, Kai Kappert, Christa Thöne-Reineke, Pierre Djoufack, Clemens Kirschbaum, Klaus B Fink, Andreas Heinz, Ulrich Kintscher, Matthias Endres, Golo Kronenberg
Evidence for a critical pathophysiological role of aberrant cytoskeletal dynamics is being uncovered in a growing number of neuropsychiatric syndromes. A sedentary lifestyle as well as overt psychopathology is prevalent in patients with the metabolic syndrome. Using mice deficient in gelsolin (Gsn-/- ), a crucial actin-severing protein, we here investigated reduced actin turnover as a potential common driver of metabolic disturbances, sedentary behavior, and an anxious/depressive phenotype. Gelsolin deficiency resulted in reduced lifespan...
April 20, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29684199/patterns-of-ses-health-disparities-among-older-adults-in-three-upper-middle-and-two-high-income-countries
#13
Mary McEniry, Rafael Samper-Ternent, Carmen Elisa Flórez, Renata Pardo, Carlos Cano-Gutierrez
Objectives: To examine the socioeconomic status (SES) health gradient for obesity, diabetes, and hypertension within a diverse group of health outcomes and behaviors among older adults (60+) in upper middle-income countries benchmarked with high-income countries. Method : We used data from three upper middle-income settings (Colombia-SABE-Bogotá, Mexico-SAGE, and South Africa-SAGE) and two high-income countries (England-ELSA and US-HRS) to estimate logistic regression models using age, gender, and education to predict health and health behaviors...
April 19, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29684094/quantitative-analyses-of-factors-related-to-anxiety-and-depression-in-patients-with-retinitis-pigmentosa
#14
Mayumi Sainohira, Takehiro Yamashita, Hiroto Terasaki, Shozo Sonoda, Kazunori Miyata, Yusuke Murakami, Yasuhiro Ikeda, Takeshi Morimoto, Takao Endo, Takashi Fujikado, Junko Kamo, Taiji Sakamoto
The purpose of this study is to determine the factors related to anxiety and depression in patients with retinitis pigmentosa (RP). The status of anxiety and depression was determined in RP patients with the Hospital Anxiety and Depression Scale (HADS) questionnaire which consisted of subscales for HADS-anxiety (HADS-A) and HADS-depression (HADS-D). The vision-specific quality of life (VSQOL) was assessed with the National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ25). The correlations between the HADS-A or HADS-D scores and vision-related clinical parameters such as the best-corrected visual acuity (BCVA), Functional Acuity Score, Functional Field Score, Functional Vision Score, the NEI- VFQ25 subscale score were determined...
2018: PloS One
https://www.readbyqxmd.com/read/29684091/impaired-visual-working-and-verbal-memory-in-first-episode-drug-naive-patients-with-major-depressive-disorder-in-a-chinese-population
#15
Ce Chen, Wen-Hui Jiang, Wei Wang, Xian-Cang Ma, Ye Li, Jin Wu, Kenji Hashimoto, Cheng-Ge Gao
Cognitive impairment has been observed in patients with major depressive disorder (MDD). However, it remains unclear whether the deficits in specific cognitive domains are present in first-episode, drug-naïve patients or medicated patients. In the present study, using the CogState battery (CSB) Chinese language version, we evaluated the visual, working, and verbal memory in first-episode drug-naive patients and medicated patients with MDD in a Chinese population. We measured the cognitive function in first-episode drug-naïve patients (n = 36), medicated MDD patients (n = 71), and age- and sex-matched healthy control subjects (n = 59) in a Chinese population...
2018: PloS One
https://www.readbyqxmd.com/read/29683028/the-factors-associated-with-anxiety-symptom-severity-in-older-adults-living-in-nursing-homes-and-other-residential-aged-care-facilities
#16
Alexandra S Creighton, Tanya E Davison, David W Kissane
OBJECTIVE: This study aimed to identify the biopsychosocial factors associated with anxiety among a residential aged care sample. METHOD: A total of 178 residents ( M age = 85.4 years, SD = 7.4 years) with mild cognitive impairment or normal cognition participated. Participants completed the Geriatric Anxiety Inventory (GAI) and a set of measures assessing cognition, depression, self-perceived health, mastery, attachment, perceived social support, social engagement, functional status, the experience of a fall, and other negative life events...
April 1, 2018: Journal of Aging and Health
https://www.readbyqxmd.com/read/29682701/selective-effects-of-5-ht2c-receptor-modulation-on-performance-of-a-novel-valence-probe-visual-discrimination-task-and-probabilistic-reversal-learning-in-mice
#17
Benjamin U Phillips, Sigma Dewan, Simon R O Nilsson, Trevor W Robbins, Christopher J Heath, Lisa M Saksida, Timothy J Bussey, Johan Alsiö
RATIONALE: Dysregulation of the serotonin (5-HT) system is a pathophysiological component in major depressive disorder (MDD), a condition closely associated with abnormal emotional responsivity to positive and negative feedback. However, the precise mechanism through which 5-HT tone biases feedback responsivity remains unclear. 5-HT2C receptors (5-HT2CRs) are closely linked with aspects of depressive symptomatology, including abnormalities in reinforcement processes and response to stress...
April 22, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29682584/patient-related-determinants-of-glycaemic-control-in-people-with-type-2-diabetes-in-the-gulf-cooperation-council-countries-a-systematic-review
#18
REVIEW
Mohammed J Alramadan, Afsana Afroz, Sultana Monira Hussain, Mohammed Ali Batais, Turky H Almigbal, Hassan Ahmad Al-Humrani, Ahmed Albaloshi, Lorena Romero, Dianna J Magliano, Baki Billah
The aim of this systematic review is to assess patient-related factors affecting glycaemic control among people with type 2 diabetes in the Arabian Gulf Council countries. MEDLINE, Embase, PsycINFO, CINAHL, and Cochrane CENTRAL databases were searched from their date of inception to May 2016. Two researchers independently identified eligible studies and assessed the risk of bias. A total of 13 studies met the inclusion criteria. One study was population based, six recruited participants from multiple centres, and the remaining were single centred...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29682494/cognitive-changes-and-brain-volume-reduction-in-patients-with-nonalcoholic-fatty-liver-disease
#19
Branka Filipović, Olivera Marković, Vesna Đurić, Branislav Filipović
Studies of psychological condition of patients suffering from nonalcoholic fatty liver disease are rather equivocal about the results: while some claim that NAFLD patients suffer from anxiety and depression more than non-NAFLD controls, others do not withstand those findings. Lower cognitive potentials have also been reported, both in patient related and in animal model-based investigations, and correlated with assessed brain tissue changes. We hypothesized that NAFLD, as a condition, affects the brain tissue and, subsequently, the cognitive state...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29682233/personality-factors-and-cognitive-functioning-in-elderly-with-parkinson-s-disease
#20
Neusa Maria de Oliveira Chardosim, Camila Rosa Oliveira, Manuela Polidoro Lima, Marianne Farina, Valéria Gonzatti, Dalton Breno Costa, Aline Sória Pereira, Luis Henrique Paloski, Tatiana Quarti Irigaray, Irani Iracema de Lima Argimon
Parkinson's disease (PD) is a chronic and progressive neurological disease, resulting from cell degeneration in the substantia nigra, responsible for the production of dopamine. Objective: This study aimed to characterize the cognitive functioning, personality factors and prevalence of depressive and anxiety symptoms in individuals with Parkinson's disease (PD). Furthermore, this study sought to analyze whether personality factors were predictors of cognitive functioning. Methods: The sample consisted of 30 elderly with PD...
January 2018: Dementia & Neuropsychologia
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