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https://www.readbyqxmd.com/read/28336432/behavioral-abnormalities-and-reduced-norepinephrine-in-ep4-receptor-associated-protein-eprap-deficient-mice
#1
Risako Fujikawa, Sei Higuchi, Taichi Ikedo, Manabu Nagata, Kosuke Hayashi, Tao Yang, Takeshi Miyata, Masayuki Yokode, Manabu Minami
EP4 receptor-associated protein (EPRAP) is a newly identified molecule that regulates macrophage activation. We recently demonstrated the presence of EPRAP in the mice brain; however, little is known about the function of EPRAP in this tissue. Therefore, we investigated the role of EPRAP in behavior and emotion using behavioral analysis in mice. In this study, we subjected EPRAP-deficient (KO) mice and wild-type C57BL/6 (WT) mice to a battery of behavioral tests. EPRAP-KO mice tended to have shorter latencies to fall in the wire hang test, but had normal neuromuscular strength...
March 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28335040/-new-ways-of-diagnosing-adhd-in-adults
#2
Marco Grabemann, Marco Zimmermann, Laura Strunz, Monika Ebbert-Grabemann, Norbert Scherbaum, Bernhard Kis, Christian Mette
Objective Diagnosing Attention-Deficit-Hyperactivity Disorder (ADHD) in adults requires that ADHD has already been present in childhood. However, recall of ADHD-symptoms in childhood is fallible, for example influenced by mood. Furthermore, diagnostics need a procedure to handle oblivion and judgment biases. The Essen-Interview-for-school-days-related-biography (EIS-B) addresses these problems and offers a tool for retrospectively diagnosing childhood ADHD in adults. Method 36 patients with ADHD, 27 patients with depression or adjustment disorders and 39 healthy controls were included in the pilot study...
March 23, 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/28333743/climate-change-and-mental-health
#3
Janna Trombley, Stephanie Chalupka, Laura Anderko
: Climate change is an enormous challenge for our communities, our country, and our world. Recently much attention has been paid to the physical impacts of climate change, including extreme heat events, droughts, extreme storms, and rising sea levels. However, much less attention has been paid to the psychological impacts. This article examines the likely psychological impacts of climate change, including anxiety, stress, and depression; increases in violence and aggression; and loss of community identity. Nurses can play a vital role in local and regional climate strategies by preparing their patients, health care facilities, and communities to effectively address the anticipated mental health impacts of climate change...
April 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28333546/pharmacokinetics-and-safety-of-vortioxetine-in-pediatric-patients
#4
Robert L Findling, Adelaide S Robb, Melissa DelBello, Michael Huss, Nora McNamara, Elias Sarkis, Russell Scheffer, Lis H Poulsen, Grace Chen, Ole Michael Lemming, Johan Areberg, Philippe Auby
OBJECTIVE: The primary objectives of this study were to evaluate the pharmacokinetics (PK) and tolerability of single and multiple doses of vortioxetine in children and adolescents with a depressive or anxiety disorder and to provide supportive information for appropriate dosing regimens for pediatric clinical trials. METHODS: This prospective, open-label, multinational, multisite, multiple-dose trial enrolled 48 patients (children and adolescents; 1:1 ratio) divided into 8 cohorts (4 adolescent and 4 child), with each cohort including 6 patients...
March 23, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28333524/developmental-origins-of-infant-emotion-regulation-mediation-by-temperamental-negativity-and-moderation-by-maternal-sensitivity
#5
Jenna C Thomas, Nicole Letourneau, Tavis S Campbell, Lianne Tomfohr-Madsen, Gerald F Giesbrecht
Emotion regulation is essential to cognitive, social, and emotional development and difficulties with emotion regulation portend future socioemotional, academic, and behavioral difficulties. There is growing awareness that many developmental outcomes previously thought to begin their development in the postnatal period have their origins in the prenatal period. Thus, there is a need to integrate evidence of prenatal influences within established postnatal factors, such as infant temperament and maternal sensitivity...
April 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28332122/cognitive-impairments-and-predominant-polarity-in-bipolar-disorder-a-cross-sectional-study
#6
Gabriel Okawa Belizario, Alexandre Duarte Gigante, Cristiana Castanho de Almeida Rocca, Beny Lafer
BACKGROUND: Bipolar disorder (BD) patients exhibit cognitive impairments during euthymic states. Studies suggest that manic episodes may be correlated to cognitive impairments. The present study investigated the relationship between predominant polarity and the cognitive deficits frequently detected in bipolar patients. We hypothesize that mania predominant polarity (MPP) patients should exhibit greater cognitive impairments in comparison to depressive (DPP) and indefinite predominant polarity (IPP) patients and healthy control (HC) individuals...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28332022/the-no-problems-problem-an-empirical-analysis-of-ceiling-effects-on-the-eq-5d-5l
#7
Alexander Konnopka, Hans-Helmut Koenig
AIM: To analyze the association between ceiling effects on the EQ-5D 5L and morbidity in a general population sample. METHODS: We used a cross-sectional sample of the German general population (n = 5007) to describe the frequency of health state "11111" and "no problems"-answers on the five single dimensions stratified by the number of diseases for which participants utilized health care during the last 6 months. For the five single dimensions we also used specific criteria to analyze their discriminative ability...
March 22, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28331356/individual-and-dyadic-coping-in-chronic-pain-patients
#8
Andrea Burri, Michèle Blank Gebre, Guy Bodenmann
The purpose of the current cross-sectional study was to test the associations between individual coping responses to pain, dyadic coping, and perceived social support, with a number of pain outcomes, including pain intensity, functional disability, and pain adjustment, in a sample of N = 43 patients suffering from chronic pain in Switzerland. In contrast to previous research, we were interested not only in specific pain coping but also in more general stress coping strategies and their potential influence on pain outcomes...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28328830/effects-of-cannabis-use-and-subclinical-depression-on-the-p3-event-related-potential-in-an-emotion-processing-task
#9
Lucy J Troup, Robert D Torrence, Jeremy A Andrzejewski, Jacob T Braunwalder
The effects of residual cannabis use on emotional expression recognition and the P3 event-related potential in participants who scored highly for subclinical depression were investigated. Comparisons were made between participants who were classified as depressed or nondepressed cannabis users, depressed non-cannabis users and controls who neither used cannabis nor were characterized as being depressed. In an emotional expression recognition task, participants were asked to respond to faces depicting happy, angry, fearful, and neutral faces either implicitly, explicitly, or empathically...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328699/a-mindfulness-program-adapted-for-adolescents-with-chronic-pain-feasibility-acceptability-and-initial-outcomes
#10
Danielle A Ruskin, Michelle M Gagnon, Sara A Kohut, Jennifer N Stinson, Kathryn S Walker
OBJECTIVES: Pediatric chronic pain is a major health issue which can lead to significant interference in daily functioning. Mindfulness-based interventions (MBI's), which emphasize acceptance rather than control of pain, have gained increasing attention as a viable treatment option among adults with chronic pain. The effectiveness of MBIs for chronic pain in pediatric populations remains largely unknown. This prospective pre-post interventional study was conducted to examine the feasibility, acceptability, and initial effectiveness of an 8-week group MBI for adolescents (MBI-A) with chronic pain...
March 21, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28327492/pet-therapy-an-effective-strategy-to-care-for-the-elderly-an-experimental-study-in-a-nursing-home
#11
Alfonso Sollami, Elisa Gianferrari, Manuela Alfieri, Giovanna Artioli, Chiara Taffurelli
BACKGROUND AND AIM: There has recently been a growing interest towards patients' affective and emotional needs, especially in relational therapies, which are considered vital as to increase the understanding of those needs and patients' well-being. In particular, we paid attention to those patients who are forced to spend the last phase of their existence in residential facilities, namely elderly people in nursing homes, who often feel marginalized, useless, depressed, unstimulated or unable to communicate...
March 14, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28326945/descending-facilitation
#12
Min Zhuo
It is documented that sensory transmission, including pain, is subject to endogenous inhibitory and facilitatory modulation at the dorsal horn of the spinal cord. Descending facilitation has received a lot of attention, due to its potentially important roles in chronic pain. Recent investigation using neurobiological approaches has further revealed the link between cortical potentiation and descending facilitation. Cortical-spinal top-down facilitation, including those relayed through brainstem neurons, provides powerful control for pain transmission at the level of the spinal cord...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28326521/anxiety-and-depression-in-women-undergoing-infertility-treatment
#13
Paulina Gdańska, Ewa Drozdowicz-Jastrzębska, Barbara Grzechocińska, Maria Radziwon-Zaleska, Piotr Węgrzyn, Mirosław Wielgoś
Infertility is a significant problem for millions of couples. Recently more attention is being paid to the relationship between infertility treatment with the use of Assisted Reproductive Techniques and the presence of mental disturbances, of which anxiety and depression are the most common. We present a review of recent studies evaluating the influence of anxiety and depression on fertility treatment outcomes and the effect of Assisted Reproductive Techniques treatment on the presence of anxiety and depression among women...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28326115/self-injury-and-suicide-attempt-in-relation-with-trauma-and-dissociation-among-adolescents-with-dissociative-and-non-dissociative-disorders
#14
Filiz Kılıç, Murat Coşkun, Hasan Bozkurt, İlyas Kaya, Salih Zoroğlu
OBJECTIVE: To explore the role of trauma and dissociation over self-injurious behaviors (SIB) and suicide attempts (SA) in adolescents. METHODS: A total of 207 adolescents participated in the study. After conducting diagnostic interview, participants were divided into five groups as subjects with dissociative disorders (DD), attention deficit hyperactivity disorder (ADHD), major depressive disorder (MDD) and anxiety disorders (AD), and a control group (CG) without any psychiatric disorder...
March 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28325682/5-httlpr-moderates-the-association-between-attention-away-from-angry-faces-and-prospective-depression-among-youth
#15
Jessica L Jenness, Jami F Young, Benjamin L Hankin
Attention bias to emotion has been studied as a risk factor associated with depression. No study has examined whether attention bias within the context of measured genetic risk leads to increased risk for clinical depressive episodes over time. The current study investigated whether genetic risk, as indexed by the serotonin-transporter-linked polymorphic region (5-HTTLPR), moderated the relationship between attention bias to emotional faces and clinical depression onset prospectively across 18-months in a community sample of youth (n = 428; mean age = 11...
February 24, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28325027/identifying-the-effects-of-visceral-interoception-on-human-brain-connectome-a-multivariate-analysis-of-covariance-of-fmri-data
#16
Behnaz Jarrahi, Dante Mantini
Sources of variations in the neural circuitry of the human brain and interrelationship between intrinsic connectivity networks (ICNs) are still a matter of debate and ongoing research. Here, we applied a multivariate analysis of covariance (MANCOVA) based on high-dimensional independent component analysis (ICA) to identify the effects of interoception and related variables on human brain connectome. Fifteen healthy right-handed subjects (all females, age range 21 - 48 years; mean age = 30.3, SD = 8.7 years) underwent a blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) that included continuous intravesical saline infusion and drainage...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28323506/emotional-and-psychosocial-factors-associated-with-drunkenness-and-the-use-of-tobacco-and-cannabis-in-adolescence-independent-or-interactive-effects
#17
Irene García-Moya, María José Ortiz Barón, Carmen Moreno
BACKGROUND: Although previous research has examined emotional and psychosocial factors associated with substance use, there is a paucity of studies examining both at the same time, and insufficient attention has been paid to how these factors may interact. OBJECTIVES: The aim of this study was to simultaneously examine the contributions from emotional (emotional control and depression) and psychosocial (peers' conventional behavior, peers' substance use and parent-child relationships) factors to drunkenness and the use of tobacco and cannabis in adolescence...
March 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28323074/an-obesogenic-refined-low-fat-diet-disrupts-attentional-and-behavioral-control-processes-in-a-vigilance-task-in-rats
#18
Aaron P Blaisdell, Traci Biedermann, Eric Sosa, Ava Abuchaei, Neveen Youssef, Sylvie Bradesi
Diets consisting of refined foods (REF) are associated with poor physical (e.g., obesity and diabetes) and mental (e.g., depression) health and impaired cognition. Few animal studies have explored the causal links between diet processing and health. Instead, most studies focus on the role of macronutrients, especially carbohydrate and fat concurrently with how processed are the ingredients. We previously showed that a REF low fat diet (LFD) caused greater adiposity and impaired motivation compared to an unrefined control (CON) diet consisting of similar macronutrient ratios (Blaisdell et al...
March 18, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28321605/long-term-effects-of-stimulant-exposure-on-cerebral-blood-flow-response-to-methylphenidate-and-behavior-in-attention-deficit-hyperactivity-disorder
#19
Anouk Schrantee, C Bouziane, E E Bron, S Klein, M A Bottelier, J J S Kooij, S A R B Rombouts, L Reneman
Stimulant prescription rates for attention deficit hyperactivity disorder (ADHD) are increasing, even though potential long-term effects on the developing brain have not been well-studied. A previous randomized clinical trial showed short-term age-dependent effects of stimulants on the DA system. We here assessed the long-term modifying effects of age-of-first-stimulant treatment on the human brain and behavior. 81 male adult ADHD patients were stratified into three groups: 1) early stimulant treatment (EST; <16 years of age) 2) late stimulant treatment (LST: ≥23 years of age) and 3) stimulant treatment naive (STN; no history of stimulant treatment)...
March 20, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28319003/insulin-resistance-and-cognitive-performance-in-type-2-diabetes-the-maastricht-study
#20
Stefan L C Geijselaers, Simone J S Sep, Miranda T Schram, Martin P J van Boxtel, Ronald M A Henry, Frans R J Verhey, Abraham A Kroon, Nicolaas C Schaper, Pieter C Dagnelie, Carla J H van der Kallen, Coen D A Stehouwer, Geert Jan Biessels
AIMS: Type 2 diabetes, hyperinsulinemia, and insulin resistance are associated with cognitive impairment. Experimental studies indicate that insulin signaling in the brain is related to cognitive performance. Here we evaluated whether insulin-related variables contribute to the variance in cognitive performance among individuals with type 2 diabetes. METHODS: A total of 806 individuals with type 2 diabetes (mean age 62±8years, HbA1c 6.9±1.1%) completed a neuropsychological test battery...
February 12, 2017: Journal of Diabetes and its Complications
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