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https://www.readbyqxmd.com/read/28830030/multivariate-trajectories-across-multiple-domains-of-health-related-quality-of-life-in-children-with-new-onset-epilepsy
#1
Tolulope T Sajobi, Meng Wang, Mark A Ferro, Anita Brobbey, Shane Goodwin, Kathy N Speechley, Samuel Wiebe
The diagnosis of epilepsy in children is known to impact the trajectory of their health-related quality of life (HRQOL) over time. However, there is limited knowledge about variations in longitudinal trajectories across multiple domains of HRQOL. This study aims to characterize the heterogeneity in HRQOL trajectories across multiple HRQOL domains and to evaluate predictors of differences among the identified trajectory groups in children with new-onset epilepsy. Data were obtained from the Health Related Quality of Life in Children with Epilepsy Study (HERQULES), a prospective multi-center study of 373 children newly diagnosed with new-onset epilepsy who were followed up over 2years...
August 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28829979/clinical-and-demographic-predictors-of-response-to-rtms-treatment-in-unipolar-and-bipolar-depressive-disorders
#2
Reza Rostami, Reza Kazemi, Michael A Nitsche, Fatemeh Gholipour, M A Salehinejad
OBJECTIVE: Previous studies investigated predictors of repetitive transcranial magnetic stimulation (rTMS) response in depressive disorders but there is still limited knowledge about clinical predictors. Moreover, predictors of rTMS response in bipolar depression (BDD) are less studied than unipolar depression (UDD). METHODS: We performed a binary logistic regression analysis in 248 patients with depressive disorders (unipolar N=102, bipolar N=146) who received 20 sessions of DLPFC rTMS (High-frequency rTMS, low-frequency rTMS, bilateral rTMS) to investigate significant clinical and demographic predictors of rTMS response...
July 24, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28828734/neurocognitive-assessment-of-emotional-context-sensitivity
#3
Sarah Myruski, George A Bonanno, Olga Gulyayeva, Laura J Egan, Tracy A Dennis-Tiwary
Sensitivity to emotional context is an emerging construct for characterizing adaptive or maladaptive emotion regulation, but few measurement approaches exist. The current study combined behavioral and neurocognitive measures to assess context sensitivity in relation to self-report measures of adaptive emotional flexibility and well-being. Sixty-six adults completed an emotional go/no-go task using happy, fearful, and neutral faces as go and no-go cues, while EEG was recorded to generate event-related potentials (ERPs) reflecting attentional selection and discrimination (N170) and cognitive control (N2)...
August 21, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28828401/abnormalities-in-dynamic-brain-activity-caused-by-mild-traumatic-brain-injury-are-partially-rescued-by-the-cannabinoid-type-2-receptor-inverse-agonist-smm-189
#4
Yu Liu, Samuel S McAfee, Natalie M Guley, Nobel Del Mar, Wei Bu, Scott A Heldt, Marcia G Honig, Bob M Moore, Anton Reiner, Detlef H Heck
Mild traumatic brain injury (mTBI) can cause severe long-term cognitive and emotional deficits, including impaired memory, depression, and persevering fear, but the neuropathological basis of these deficits is uncertain. As medial prefrontal cortex (mPFC) and hippocampus play important roles in memory and emotion, we used multi-site, multi-electrode recordings of oscillatory neuronal activity in local field potentials (LFPs) in awake, head-fixed mice to determine if the functioning of these regions was abnormal after mTBI, using a closed-skull focal cranial blast model...
July 2017: ENeuro
https://www.readbyqxmd.com/read/28828207/cerebral-gray-matter-volume-reduction-in-subcortical-vascular-mild-cognitive-impairment-patients-and-subcortical-vascular-dementia-patients-and-its-relation-with-cognitive-deficits
#5
Maoyu Li, Yao Meng, Minzhong Wang, Shuang Yang, Hui Wu, Bin Zhao, Guangbin Wang
INTRODUCTION: Subcortical vascular mild cognitive impairment (svMCI) is the predementia stage of subcortical vascular dementia (SVaD). The aim of this research is to explore and compare cerebral gray matter (GM) volume reduction in svMCI patients and SVaD patients, and to investigate the relationship between cerebral GM volume reduction and cognitive deficits. METHODS: Thirty one svMCI patients, 29 SVaD patients, and 31 healthy controls were recruited in our research...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828187/exercise-promotes-neuroplasticity-in-both-healthy-and-depressed-brains-an-fmri-pilot-study
#6
Joanne Gourgouvelis, Paul Yielder, Bernadette Murphy
Memory impairments are a frequently reported cognitive symptom in people suffering from major depressive disorder (MDD) and often persist despite antidepressant therapy. Neuroimaging studies have identified abnormal hippocampal activity during memory processes in MDD. Exercise as an ad-on treatment for MDD is a promising therapeutic strategy shown to improve mood, cognitive function, and neural structure and function. To advance our understanding of how exercise impacts neural function in MDD, we must also understand how exercise impacts healthy individuals without MDD...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28827697/gait-speed-rather-than-dynapenia-is-a-simple-indicator-for-complex-care-needs-a-cross-sectional-study-using-minimum-data-set
#7
Tzu-Ya Huang, Chih-Kuang Liang, Hsiu-Chu Shen, Hon-I Chen, Mei-Chen Liao, Ming-Yueh Chou, Yu-Te Lin, Liang-Kung Chen
The impact of dynapenia on the complexity of care for residents of long-term care facilities (LTCF) remains unclear. The present study evaluated associations between dynapenia, care problems and care complexity in 504 residents of Veterans Care Homes (VCHs) in Taiwan. Subjects with dynapenia, defined as low muscle strength (handgrip strength <26 kg), were older adults with lower body mass index (BMI), slow gait speed, and higher numbers of Resident Assessment Protocol (RAP) triggers. After adjusting for age, education, BMI, and Charlson's comorbidity index (CCI), only age, education, BMI and gait speed were independently associated with higher numbers of RAP triggers, but not dynapenia or handgrip strength (kg)...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28826872/determinants-of-behavioral-and-psychological-symptoms-of-dementia-a-scoping-review-of-the-evidence
#8
Ann Kolanowski, Marie Boltz, Elizabeth Galik, Laura N Gitlin, Helen C Kales, Barbara Resnick, Kimberly S Van Haitsma, Amy Knehans, Jane E Sutterlin, Justine S Sefcik, Wen Liu, Darina V Petrovsky, Lauren Massimo, Andrea Gilmore-Bykovskyi, Margaret MacAndrew, Glenna Brewster, Vycki Nalls, Ying-Ling Jao, Naomi Duffort, Danny Scerpella
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are prevalent in people with neurodegenerative diseases. PURPOSE: In this scoping review the Kales, Gitlin and Lykestos framework is used to answer the question: What high quality evidence exists for the patient, caregiver and environmental determinants of five specific BPSD: aggression, agitation, apathy, depression and psychosis? METHOD: An a priori review protocol was developed; 692 of 6013 articles retrieved in the search were deemed eligible for review...
June 16, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28826415/differentiating-bipolar-disorders-from-unipolar-depression-by-applying-the-brief-assessment-of-cognition-in-affective-disorders
#9
C-Y Lee, L-J Wang, Y Lee, C-F Hung, Y-C Huang, M-I Lee, S-Y Lee
BACKGROUND: Scholars continue to argue about whether bipolar disorders (BD) and unipolar depression (UD) are distinguishable with regard to neurocognitive function. This study aims to explore the cognitive profiles of UD and BD by applying the Brief Assessment of Cognition in Affective Disorders (BAC-A) for neuropsychological assessment. METHOD: This cross-sectional study included 68 patients with UD, 67 patients with BD, and 135 healthy control subjects. We evaluated the participants' cognitive functions at euthymic status using the BAC-A, which is made up of six traditional cognitive subtests and the Affective Processing Test...
August 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28826327/positive-memory-enhancement-training-for-individuals-with-major-depressive-disorder
#10
Kimberly A Arditte Hall, Rudi De Raedt, Kiara R Timpano, Jutta Joormann
When in a negative mood state, individuals with major depressive disorder (MDD) may have difficulties recalling positive autobiographical memories in a manner that repairs that negative mood. Using cognitive bias modification techniques, investigators have successfully altered different aspects of cognition among individuals with MDD. However, little has been done to investigate the modification of positive autobiographical memory recall. This study examined the impact of a novel positive memory enhancement training (PMET) on the memories and subjective affective experiences of individuals with MDD (N = 27)...
August 22, 2017: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/28822879/patient-recall-of-specific-cognitive-therapy-contents-predicts-adherence-and-outcome-in-adults-with-major-depressive-disorder
#11
Lu Dong, Xin Zhao, Stacie L Ong, Allison G Harvey
The current study examined whether and which specific contents of patients' memory for cognitive therapy (CT) were associated with treatment adherence and outcome. Data were drawn from a pilot RCT of forty-eight depressed adults, who received either CT plus Memory Support Intervention (CT + Memory Support) or CT-as-usual. Patients' memory for treatment was measured using the Patient Recall Task and responses were coded into cognitive behavioral therapy (CBT) codes, such as CBT Model and Cognitive Restructuring, and non-CBT codes, such as individual coping strategies and no code...
August 10, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28822756/differences-in-psychosocial-and-behavioral-variables-by-dietary-screening-tool-risk-category-in-older-adults
#12
Geoffrey W Greene, Ingrid Lofgren, Chelsea Paulin, Mary L Greaney, Phillip G Clark
BACKGROUND: The Dietary Screening Tool (DST) has been validated as a dietary screening instrument for older adults defining three categories of potential nutritional risk based on DST score cutoffs. Previous research has found that older adults classified as being "at risk" differed from those categorized as being "not at risk" for a limited number of health-related variables. The relationship between risk categories and a wide variety of variables has not yet been explored. This research will contribute to an increased understanding of clustering of multiple health concerns in this population...
August 17, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28822299/avoidance-and-depression-vulnerability-an-examination-of-avoidance-in-remitted-and-currently-depressed-individuals
#13
Leanne Quigley, Alainna Wen, Keith S Dobson
Behavioral theories posit that depression is characterized by heightened levels of avoidance, and recent research has supported this notion. Whether avoidance persists after remission from depression is unknown, however. In this study, we investigated levels of cognitive and behavioral avoidance in remitted, currently, and never depressed individuals. We also examined relationships among avoidance and purported adaptive and maladaptive emotion regulation strategies. Remitted depressed individuals exhibited levels of cognitive and behavioral avoidance, in social and nonsocial domains, that were greater than nonclinical control individuals but lower than currently depressed individuals...
July 27, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28821923/ankg-hemizygous-mice-present-cognitive-impairment-and-elevated-anxiety-depressive-like-traits-associated-with-decreased-expression-of-gaba-receptors-and-postsynaptic-density-protein
#14
Cui Liu, Ling Zhang, Jie Wu, Xiaolong Sui, Yanfeng Xu, Lan Huang, Yunlin Han, Hua Zhu, Yanhong Li, Xiuping Sun, Chuan Qin
Recent genome-wide association studies (GWAS) of patient populations and genetic linkage assessments have demonstrated that the ankyrin-G (AnkG) gene is involved in neuropsychiatric disorders, including bipolar disorder, schizophrenia, and Alzheimer's disease, but it remains unclear how the genetic variants of AnkG contribute to neuropsychiatric disorders. Here, we generated AnkG hemizygous mice using the gene trapping approach. Homozygous AnkG was embryonically lethal. Western blotting and real-time polymerase chain reaction (qPCR) assessments of wild type (WT) and AnkG (+/-) mutant mice demonstrated a 50% reduction of ANKG levels, at the gene and protein levels, in AnkG hemizygous mice...
August 18, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28820903/prominent-facilitation-at-beta-and-gamma-frequency-range-revealed-with-physiological-calcium-concentration-in-adult-mouse-piriform-cortex-in-vitro
#15
Marie Gleizes, Simon P Perrier, Caroline Fonta, Lionel G Nowak
Neuronal activity is characterized by a diversity of oscillatory phenomena that are associated with multiple behavioral and cognitive processes, yet the functional consequences of these oscillations are not fully understood. Our aim was to determine whether and how these different oscillatory activities affect short-term synaptic plasticity (STP), using the olfactory system as a model. In response to odorant stimuli, the olfactory bulb displays a slow breathing rhythm as well as beta and gamma oscillations...
2017: PloS One
https://www.readbyqxmd.com/read/28819922/therapeutic-alliance-client-need-for-approval-and-perfectionism-as-differential-moderators-of-response-to-ehealth-and-traditionally-delivered-treatments-for-comorbid-depression-and-substance-use-problems
#16
Frances J Kay-Lambkin, Amanda L Baker, Kerrin Palazzi, Terry J Lewin, Brian J Kelly
PURPOSE: This study sought to undertake an exploratory analysis of the impact of therapeutic alliance and dysfunctional attitudes (perfectionism and need for approval) on outcomes for participants receiving therapist-delivered and eHealth interventions for comorbid depression and alcohol/cannabis use problems. These factors have been shown in previous research to moderate response to psychological treatment for depression and related disorders. METHOD: Participants (N = 274) with concurrent depression and alcohol/cannabis misuse were randomized to 10 sessions of therapist-delivered cognitive behavior therapy/motivational interviewing (CBT/MI), computer-delivered CBT/MI with brief therapist assistance (SHADE CBT/MI), or supportive counseling (PCT)...
August 17, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28819579/dual-task-performance-in-gba-parkinson-s-disease
#17
Karin Srulijes, Kathrin Brockmann, Senait Ogbamicael, Markus A Hobert, Ann-Kathrin Hauser, Claudia Schulte, Jasmin Fritzen, Michael Schwenk, Thomas Gasser, Daniela Berg, Walter Maetzler
INTRODUCTION: Parkinson's disease patients carrying a heterozygous mutation in the gene glucocerebrosidase (GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson's disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT) requires a smooth integration of motor and nonmotor operations. This study compared the DT performances between GBA-PD and iPD patients. METHODS: Eleven GBA-PD patients (p...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28819339/depression-after-stroke-in-sub-saharan-africa-a-systematic-review-and-meta-analysis
#18
REVIEW
Akin Ojagbemi, Onoja Akpa, Fisayo Elugbadebo, Mayowa Owolabi, Bruce Ovbiagele
OBJECTIVE: We aimed to conduct a systematic review and meta-analysis of prevalence and characteristics of poststroke depression (PSD) in sub-Saharan Africa (SSA). METHODS: We searched Medline, PsycINFO, and African Journals OnLine using keywords for stroke and depression and the .mp. operator for all 54 SSA countries/regions. Further information was retrieved through a manual search of references from relevant published and unpublished articles. We included only peer-reviewed original studies with epidemiological or experimental designs, conducted random-effect meta-analysis, and identified the most commonly associated factors by weight (inverse of variance method)...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28819243/temporal-profiling-of-depression-vulnerability-in-a-preclinical-model-of-sustained-depression
#19
D Riga, L J M Schmitz, W J G Hoogendijk, A B Smit, S Spijker
Major Depression is a prevalent mental disorder that is characterized by negative mood and reduced motivation, and frequently results in social withdrawal and memory-related deficits. Repeated stressors, such as adverse life events, increase the risk for development of the disorder. Consequently, individual variability in stress response greatly weighs on depression-vulnerability and -resilience. Here, we employed the social defeat-induced persistent stress (SDPS) paradigm to identify depression-prone individuals and to examine the temporal development of depression in the months following exposure to brief defeat stress...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818761/the-effect-of-disability-and-depression-on-cognitive-function-and-screening-factors
#20
Chun-Min Chen, Li-Fan Liu
INTRODUCTION: There is increasing evidence that subtle losses in cognitive function may be symptomatic of a transition to early dementia. The objectives of this study were to: 1) test the effect of depressive symptoms and/or disability on cognitive impairment, 2) explore the interaction between depression and disability and the association with cognitive impairment, and 3) evaluate risk factors of health assessment to discriminate between elderly people with or without cognitive impairment...
July 31, 2017: Archives of Gerontology and Geriatrics
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