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https://www.readbyqxmd.com/read/28437452/enhanced-antibacterial-metabolite-production-through-the-application-of-statistical-methodologies-by-a-streptomyces-nogalater-niist-a30-isolated-from-western-ghats-forest-soil
#1
Jubi Jacob, Reshma Uma Rajendran, Syama Hari Priya, Jayamurthy Purushothaman, Dileep Kumar Bhaskaran Nair Saraswathy Amma
Streptomyces strains isolated from Nelliyampathy forest soil of Western Ghats, Kerala, India were evaluated for their antibacterial efficacy against two indicator pathogenic bacteria (Escherichia coli and Staphylococcus aureus). Among 140 strains tested, sixteen recorded potent antibacterial properties and were further screened against eleven bacterial pathogens. A strain identified as Streptomyces nogalater and designated as NIIST A30 exhibited maximum inhibition against all the test pathogens. Among the eight fermentation media tested, inorganic salts starch broth recorded the best for antibacterial production...
2017: PloS One
https://www.readbyqxmd.com/read/28417301/overview-of-coronary-heart-disease-risk-initiatives-in-south-asia
#2
REVIEW
Ankur Kalra, Deepak L Bhatt, Sanjay Rajagopalan, Kunal Suri, Sundeep Mishra, Romaina Iqbal, Salim S Virani
PURPOSE OF REVIEW: Cardiovascular disease (CVD) is now the leading cause of morbidity and mortality worldwide. Industrialization and economic growth have led to an unprecedented increment in the burden of CVD and their risk factors in less industrialized regions of the world. While there are abundant data on CVD and their risk factors from longitudinal cohort studies done in the West, good-quality data from South Asia are lacking. RECENT FINDINGS: Several multi-institutional, observational, prospective registries, and epidemiologic cohorts in South Asia have been established to systematically evaluate the burden of CVD and their risk factors...
June 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28417039/a-true-human-tail-in-a-neonate-case-report-and-literature-review
#3
Mahesh K Pillai, Smitha T Nair
A true human tail is a benign vestigial caudal cutaneous structure composed of adipose, connective tissue, muscle, vessels, nerves and mechanoreceptors. A true human tail can be distinguished from a pseudotail as the latter is commonly associated with underlying spinal dysraphism, which requires specialised management. True human tails are very rare, with fewer than 40 cases reported to date. We report a healthy one-day-old male newborn who was referred to the Bharath Hospital, Kottayam, Kerala, India, in 2014 with a cutaneous appendage arising from the lumbosacral region...
February 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28410705/patients-perception-towards-directly-observed-treatment-a-qualitative-study-from-kollam-district-kerala-southern-india
#4
P S Rakesh, Shibu Balakrishnan, V Krishnaveni, Vishnu Narayanan, Swapna Pillai, Sumi Merin Thomas
BACKGROUND: The Direct Observation of Treatment (DOT) is an important component of the country's TB Control strategy. Standards of TB care in India and the End TB strategy emphasised the importance of a patient-centered approach to foster adherence. A qualitative study was conducted to explore the perception of people with Tuberculosis in Kerala regarding DOT, mechanisms to make the treatment of TB more patients centered and to identify the preferable mechanisms to ensure adherence. METHODS: Six focus group discussions were conducted - two among people with TB from rural area, two among people with TB in urban area, one among multipurpose health workers of rural area and one among key field staff of TB control in urban area...
April 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28407807/subclinical-inflammation-associated-with-prolonged-timp-1-upregulation-and-arterial-stiffness-after-gestational-diabetes-mellitus-a-hospital-based-cohort-study
#5
Tiina Vilmi-Kerälä, Anneli Lauhio, Taina Tervahartiala, Outi Palomäki, Jukka Uotila, Timo Sorsa, Ari Palomäki
BACKGROUND: Gestational diabetes mellitus (GDM) has significant implications for the future health of the mother. Some clinical studies have suggested subclinical inflammation and vascular dysfunction after GDM. We aimed to study whether concentrations of high-sensitivity C-reactive protein (hsCRP), tissue inhibitor of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-8 (MMP-8) and -9, as well as values of arterial stiffness differ between women with and without a history of GDM a few years after delivery...
April 13, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28400936/clinical-profile-and-management-of-poisoning-with-suicide-tree-an-observational-study
#6
M Suraj Menon, Prasantha Kumar, C I Jayachandran
INTRODUCTION: The clinical features, management, and the associations of dosage in poisoning with the cardiotoxic plant Cerbera odollam (suicide tree), responsible for more than half of plant poisoning deaths in the South Indian State of Kerala alone, have not been evaluated. There are only few studies on its clinical features and none on the usage of cardiac pacing in its management, given its rarity in the Western world. We depend on data for similar toxins to form our management protocols...
October 2016: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/28400039/population-access-to-reperfusion-services-for-st-segment-elevation-myocardial-infarction-in-kerala-india
#7
Anoop Mathew, Jabir Abdullakutty, Placid Sebastian, Sunitha Viswanathan, Cibu Mathew, Venugopalan Nair, Padinhare P Mohanan, A George Koshy
BACKGROUND: Population access to timely reperfusion is a decisive factor in determining the success and acceptability of any regional system of ST-segment elevation myocardial infarction (STEMI) care. We sought to determine the proportion of population of the southern Indian state of Kerala having timely access to STEMI reperfusion. METHODS: We identified the STEMI reperfusion facilities available at all acute-care hospitals, in Kerala, by conducting a cross-sectional survey...
April 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28384971/awareness-of-dental-trauma-management-among-school-teachers-of-kannur-kerala-india
#8
Divya Chandukutty, Faizal C Peedikayil, Chandru T Premkumar, Dhanesh Narasimhan, Deepak Jose
INTRODUCTION: Dental trauma can overtake dental caries and periodontal disease as the most significant threat to dental health among young people. The prognosis of traumatized teeth depends on prompt and appropriate treatment. The role of school teachers in the prevention of traumatic dental injuries is a topic that has received a great deal of attention in recent years. However, studies conducted in different regions of the world have demonstrated that teachers and other lay people's knowledge about traumatic dental injuries is inadequate and their behavior does not contribute to reduce the sequelae...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28361823/prevalence-correlates-of-tobacco-use-among-adolescents-in-kerala-india
#9
T S Jaisoorya, K V Beena, M Beena, Dalia C Jose, K Ellangovan, K Thennarasu, Vivek Benegal
BACKGROUND & OBJECTIVES: Most tobacco users who initiate its use during adolescence are likely to continue the use into adulthood and contribute to the 90 per cent of premature deaths among tobacco users. In this context the prevalence, patterns and correlates of tobacco use were studied among adolescent school students in Kerala, India. METHODS: Total 7560 students from classes 8, 10 and 12, within the age group of 12-19 yr, across 73 schools in Ernakulam district, Kerala, India, selected by cluster random sampling, completed a self-administered questionnaire incorporating standardized instruments...
November 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28358589/evaluation-of-genetic-diversity-population-structure-and-relationship-between-legendary-vechur-cattle-and-crossbred-cattle-of-kerala-state-india
#10
G Radhika, T V Aravindakshan, S Jinty, K Ramya
The legendary Vechur cattle of Kerala, described as a very short breed, and the crossbred (CB) Sunandini cattle population exhibited great phenotypic variation; hence, the present study attempted to analyze the genetic diversity existing between them. A set of 14 polymorphic microsatellites were chosen from FAO-ISAG panel and amplified from genomic DNA isolated from blood samples of 30 Vechur and 64 unrelated crossbred cattle, using fluorescent labeled primers. Both populations revealed high genetic diversity as evidenced from high observed number of alleles, Polymorphic Information Content and expected heterozygosity...
March 30, 2017: Animal Biotechnology
https://www.readbyqxmd.com/read/28356147/genotypic-and-phenotypic-characterization-of-g6pd-deficiency-in-bengali-adults-with-severe-and-uncomplicated-malaria
#11
Katherine Plewes, Ingfar Soontarawirat, Aniruddha Ghose, Germana Bancone, Hugh W F Kingston, M Trent Herdman, Stije J Leopold, Haruhiko Ishioka, Md Abul Faiz, Nicholas M Anstey, Nicholas P J Day, Md Amir Hossain, Mallika Imwong, Arjen M Dondorp, Charles J Woodrow
BACKGROUND: Control of malaria increasingly involves administration of 8-aminoquinolines, with accompanying risk of haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Few data on the prevalence and genotypic basis of G6PD deficiency are available from Bangladesh, where malaria remains a major problem in the South (Chittagong Division). The aim of this study was to determine the prevalence of G6PD deficiency, and associated G6PD genotypes, in adults with falciparum malaria in southern Bangladesh...
March 29, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28352198/antimicrobial-susceptibility-profile-treatment-outcome-and-serotype-distribution-of-clinical-isolates-of-salmonella-enterica-subspecies-enterica-a-2-year-study-from-kerala-south-india
#12
Deepa Harichandran, Kavitha Radhakrishnan Dinesh
BACKGROUND/PURPOSE: Typhoid and paratyphoid fever continue to be important causes of illness and death in parts of Asia, being associated with poor sanitation and consumption of unsafe food and water. Antimicrobial resistance has emerged to traditional first-line drugs, namely, the fluoroquinolones, as well as to third-generation cephalosporins, posing challenges to treatment. Azithromycin has proven to be an effective alternative for treatment of uncomplicated typhoid fever. The purpose of this study was to determine the antimicrobial susceptibility, clinical outcome and serotype distribution pattern of clinical isolates belonging to Salmonella enterica subspecies enterica...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28351753/the-brief-multidimensional-students-life-satisfaction-scale-bmslss-reliability-validity-and-gender-invariance-in-an-indian-adolescent-sample
#13
Jayana Hashim, Shaljan Areepattamannil
This study examined the internal consistency reliability, factorial, convergent, discriminant, and predictive validity, as well as gender invariance of the Brief Multidimensional Students' Life Satisfaction Scale (BMSLSS; Seligson, Huebner, & Valois, 2003) in a sample of 445 adolescents (Mage = 16.04 years) hailing from the southernmost state of India, Kerala. The study also examined the test-retest reliability (n = 392) of the BMSLSS. The Cronbach's alpha coefficient suggested that the BMSLSS was reliable...
March 25, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28327413/domestic-dogs-as-reservoir-hosts-for-leishmania-donovani-in-the-southernmost-western-ghats-in-india
#14
P Jambulingam, N Pradeep Kumar, S Nandakumar, K P Paily, R Srinivasan
The peripheral blood samples from domestic dogs (n=47) and wild rats (n=25) in the Kani Tribe settlements, located southernmost part of the Western Ghats, Thiruvananthapuram district, Kerala, India were examined for Leishmania infection. This area is known for cases of leishmaniasis with cutaneous manifestations and sandfly abundance. The tribes domesticate dogs to protect them from untoward activities of wild animals. Leishmania donovani parasite DNA was detected only from 6.4% (n=3) of the blood samples collected from the domestic dogs by amplification of the diagnostic kinetoplast mini-circle DNA and PCR-RFLP analysis of the UTR region of heat shock protein 70 (hsp70) gene...
March 19, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28323558/reproductive-tract-infections-attitude-and-barriers-among-marginalized-fisher-women-in-kerala-south-india
#15
Manoj A Thomas, Poornima Narayan
Reproductive tract infections (RTIs) are the cause of severe gynecological and maternal morbidity in India. In marginalized communities, women persevere quietly when faced with a culturally sensitive health issue such as an RTI. To hypothesize on the differential health behavior and low levels of reported incidents among women living in marginalized communities, we undertake an exploratory study in a coastal fishermen community in South India. We identify barriers influencing decisions to seek curative and preventive medical care...
April 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28316881/occurrence-of-concurrent-infections-with-multiple-serotypes-of-dengue-viruses-during-2013-2015-in-northern-kerala-india
#16
Manchala Nageswar Reddy, Ranjeet Dungdung, Lathika Valliyott, Rajendra Pilankatta
BACKGROUND: Dengue is a global human public health threat, causing severe morbidity and mortality. The occurrence of sequential infection by more than one serotype of dengue virus (DENV) is a major contributing factor for the induction of Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS), two major medical conditions caused by DENV infection. However, there is no specific drug or vaccine available against dengue infection. There are reports indicating the increased incidence of concurrent infection of dengue in several tropical and subtropical regions...
2017: PeerJ
https://www.readbyqxmd.com/read/28316390/sem-studies-on-acanthocephalan-parasite-echinorhynchus-veli-infecting-the-fish-synaptura-orientalis-bl-sch-1801
#17
S H Sheema, M V John, P V George
Echinorhynchus veli (George and Nadakal, 1978), an acanthocephalid worm infesting the estuarine flat fish, Synaptura orientalis, was collected from the Veli lake, Kerala. The parasite was recovered from the intestine of the host fish. The detailed surface morphology was studied with the help of scanning electron microscope. The study revealed a cylindrical, medially swollen proboscis with a flat apex, backward directed hooks, each with smooth surface, broad base, pointed tip and an epidermal elevation at the point of insertion...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28298838/median-and-common-peroneal-neuropathy-in-coir-workers-of-alappuzha-district-kerala
#18
Sadanandavalli Retnaswami Chandra, Biji Anand, Thomas Gregor Issac
INTRODUCTION: Coir work, in a large number of people involves mechanically rolling the coconut fibers into coir which is later subjected to various processes. The primary work is done as a cottage industry specially by women in the sitting posture for several hours. This study reports evidence of median and common peroneal neuropathy electrophysiologically in people who had been engaged in this job for several years. This study was initiated to establish the possible relationship between coir work and symptomatic neuropathies which was seen in that region with all investigations "for other causes not" contributing to the etiological diagnosis...
January 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28290398/government-medical-college-trivandrum-fifty-years-of-neurosurgery-in-kerala-state
#19
Anil Kumar Peethambaran, Raj S Chandran
The Department of Neurosurgery founded in the Trivandrum Medical College, Kerala, the first teaching hospital in Kerala state, is celebrating its 50th anniversary. The history of Neurosurgery in this Institute is synonymous with the history of Neurosurgery in the state as this was the first medical college to start a Neurosurgery department within the state.The students after undergoing their rigorous training in the department, went on to establish advanced neurosurgical centres throughout Kerala and in several other parts of the country...
March 2017: Neurology India
https://www.readbyqxmd.com/read/28267469/acute-coronary-syndrome-quality-improvement-in-kerala-acs-quik-rationale-and-design-for-a-cluster-randomized-stepped-wedge-trial
#20
Mark D Huffman, Padinhare Purayil Mohanan, Raji Devarajan, Abigail S Baldridge, Dimple Kondal, Lihui Zhao, Mumtaj Ali, Donald M Lloyd-Jones, Dorairaj Prabhakaran
Ischemic heart disease is the leading cause of death in India, and there are likely more myocardial infarctions in India than in any other country in the world. We have previously reported heterogeneous care for patients with myocardial infarction in Kerala, a state in southern India, including both gaps in optimal care and inappropriate care. Based on that prior work, limitations from previous nonrandomized quality improvement studies and promising gains in process of care measures demonstrated from previous randomized trials, we and the Cardiological Society of India-Kerala chapter sought to develop, implement, and evaluate a quality improvement intervention to improve process of care measures and clinical outcomes for these patients...
March 2017: American Heart Journal
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