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https://www.readbyqxmd.com/read/29024348/obesity-as-a-risk-factor-for-alzheimer-s-disease-weighing-the-evidence
#1
REVIEW
S Alford, D Patel, N Perakakis, C S Mantzoros
Alzheimer's disease (AD) is the sixth leading cause of death in the USA today; therefore, it is imperative that public health initiatives and clinical strategies are developed to prevent and effectively treat AD. Despite the enormous impact that AD has on individuals, families, society, and the health care system, there are no biomarkers to clearly identify those at risk for AD, public health prevention strategies in place, or treatments to address the underlying pathology or stop the progression of AD. There is ample scientific as well as empirical evidence that obesity and its metabolic and vascular comorbidities are related to AD and likely in the causative pathway...
October 10, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29023974/diabetes-related-major-lower-limb-amputation-incidence-is-strongly-related-to-diabetic-foot-service-provision-and-improves-with-enhancement-of-services-peer-review-of-the-south-west-of-england
#2
R B Paisey, A Abbott, R Levenson, A Harrington, D Browne, J Moore, M Bamford, M Roe
AIMS: To investigate the relationship between high diabetes-related lower limb amputation incidence and foot care services in the South-West region of England. METHODS: The introduction of 10 key elements of foot care service provision in one area of the South-West resulted in stabilization of foot ulcer incidence and sustained reduction in amputation incidence from 2007. Services introduced included administrative support, standardized general practice foot screening, improved community podiatry staffing, hospital multidisciplinary foot clinics, effective care pathways, availability of an orthotist and audit...
October 11, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28992159/compliance-with-accreditation-and-recommended-hospital-care-a-danish-nationwide-population-based-study
#3
Anne Mette Falstie-Jensen, Søren Bie Bogh, Erik Hollnagel, Søren Paaske Johnsen
Objective: To examine the association between compliance with accreditation and recommended hospital care. Design: A Danish nationwide population-based follow-up study based on data from six national, clinical quality registries between November 2009 and December 2012. Setting: Public, non-psychiatric Danish hospitals. Participants: Patients with acute stroke, chronic obstructive pulmonary disease, diabetes, heart failure, hip fracture and bleeding/perforated ulcers...
October 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28981239/-diabetes-care-pathways-and-the-diabetic-convention-in-2017
#4
V de Brouckère, L Plat
Diabetes is a chronic, pandemic disorder which has a growing impact on healthcare costs and leads to severe micro- and macro-vascular complications. In 2009, Belgium introduced " care trajectories " (CT), a program which allows multidisciplinary management of this disease. CT is built on a partnership between three parties: the patient (central to the concept), the general practitioner (GP) and the diabetologist. The GP is responsible for the medical management according to an individualized care plan. The specialist's task is to update the GPs' knowledge and to coach them...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28979077/developing-an-integrated-treatment-pathway-for-a-post-coronary-artery-bypass-grating-cabg-geriatric-patient-with-comorbid-hypertension-and-type-1-diabetes-mellitus-for-treating-acute-hypoglycemia-and-electrolyte-imbalance
#5
Atta Abbas Naqvi, Amna Shah, Rizwan Ahmad, Niyaz Ahmad
INTRODUCTION: The ailments afflicting the elderly population is a well-defined specialty of medicine. It calls for an immaculately designed health-care plan to treat diseases in geriatrics. For chronic illnesses such as diabetes mellitus (DM), coronary heart disease, and hypertension (HTN), they require proper management throughout the rest of patient's life. An integrated treatment pathway helps in treatment decision-making and improving standards of health care for the patient. CASE PRESENTATION: This case describes an exclusive clinical pharmacist-driven designing of an integrated treatment pathway for a post-coronary artery bypass grafting (CABG) geriatric male patient with DM type I and HTN for the treatment of hypoglycemia and electrolyte imbalance...
July 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28956976/parastomal-hernia-and-physical-activity-are-patients-getting-the-right-advice
#6
Sarah Russell
This article draws on a large nationwide survey (2631 respondents) that investigated the physical health and wellbeing of people living with stomas in the UK. It specifically considers the findings relating to parastomal hernia (where additional loops of bowel protrude through the abdominal wall around the stoma, creating a bulge). In this survey, 26% of respondents reported that they had a medically diagnosed parastomal hernia, which is below average when compared with other estimates. The impact of parastomal hernia on physical activity levels was the most significant finding: 32% of those with a medically diagnosed hernia reported being 'much less active' than they were prior to their surgery (compared with 19% without a hernia)...
September 28, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28956186/diabetic-nephropathy-a-tangled-web-to-unweave
#7
REVIEW
Corey Magee, David J Grieve, Chris J Watson, Derek P Brazil
Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease globally. Given the increasing incidence of diabetes, many experts hold the view that DN will eventually progress toward pandemic proportions. Whilst hyperglycaemia-induced vascular dysfunction is the primary initiating mechanism in DN, its progression is also driven by a heterogeneous set of pathological mechanisms, including oxidative stress, inflammation and fibrosis. Current treatment strategies for DN are targeted against the fundamental dysregulation of glycaemia and hypertension...
September 27, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28949996/the-impact-of-team-based-interprofessional-comprehensive-assessments-on-the-diagnosis-and-management-of-diabetic-foot-ulcers-a-retrospective-cohort-study
#8
Ranjani Somayaji, James A Elliott, Reneeka Persaud, Morgan Lim, Laurie Goodman, R Gary Sibbald
BACKGROUND: Diabetic foot ulcers (DFU) are increasingly prevalent, and associated with significant morbidity, mortality, and cost. An interprofessional approach to DFU management is critical given the etiological complexity involved. This study aimed to assess the impact of an interprofessional team approach on DFU diagnosis and management for a cohort of patients receiving treatment in an Ontario Canada home care setting. METHODS: A retrospective cohort study of patients attending a large regional Community Care Access Centre (CCAC) between February 11, 2013-September 30, 2014 was conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28945454/review-of-integrated-behavioral-health-in-primary-care-step-by-step-guidance-for-assessment-and-intervention-second-edition
#9
Stacy A Ogbeide
Reviews the book, Integrated Behavioral Health in Primary Care: Step-By-Step Guidance for Assessment and Intervention (Second Edition) by Anne C. Dobmeyer, Mark S. Oordt, Jeffrey L. Goodie, and Christopher L. Hunter (see record 2016-59132-000). This comprehensive book is well organized and covers many of the complex issues faced within the Primary Care Behavioral Health (PCBH) model and primary care setting: from uncontrolled type II diabetes to posttraumatic stress disorder. Primary care has changed since the initial release of this book, and the second edition covers many of these changes with up-to-date literature such as population health and the patient-centered medical home...
September 2017: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/28939397/national-survey-of-emergency-physicians-concerning-home-based-care-options-as-alternatives-to-emergency-department-based-hospital-admissions
#10
Amy R Stuck, Christopher Crowley, James Killeen, Edward M Castillo
BACKGROUND: Emergency departments (EDs) in the United States play a prominent role in hospital admissions, especially for the growing population of older adults. Home-based care, rather than hospital admission from the ED, provides an important alternative, especially for older adults who have a greater risk of adverse events, such as hospital-acquired infections, falls, and delirium. OBJECTIVE: The objective of the survey was to understand emergency physicians' (EPs) perspectives on home-based care alternatives to hospitalization from the ED...
September 19, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28938479/pulmonary-function-and-sleep-breathing-two-new-targets-for-type-2-diabetes-care
#11
Albert Lecube, Rafael Simó, Maria Pallayova, Naresh M Punjabi, Carolina López-Cano, Cecilia Turino, Cristina Hernández, Ferran Barbé
Population based studies showing the negative impact of type 2 diabetes (T2D) on lung function are overviewed. Among the well-recognized pathophysiological mechanisms, the metabolic pathways related to insulin resistance, low-grade chronic inflammation, leptin resistance, microvascular damage, and autonomic neuropathy are emphasized. Histopathological changes are exposed, and findings reported from experimental models are clearly differentiated from those described in humans. The accelerated decline in pulmonary function that appears in patients with cystic fibrosis with related abnormalities of glucose tolerance and diabetes is considered as an example to further investigate the relationship between T2D and the lung...
September 4, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28923179/drugs-and-hyperglycemia-a-practical-guide
#12
REVIEW
Vandana Jain, Ronak Kumar Patel, Zaureen Kapadia, Sneha Galiveeti, Maryann Banerji, Lisel Hope
Drug-induced diabetes is one of the factors contributing to the increasing incidence of diabetes worldwide. This review considers the frequency, pathogenesis and treatment of drug-induced diabetes. Drugs that induce diabetes include hormonal therapy, especially glucocorticoids and androgen blockers, cardiovascular drugs, especially statins, beta-blockers and diuretics, antipsychotics, especially clozapine, olanzapine and quetiapine, antiretrovirals (protease inhibitors and non-reverse transcriptase inhibitors - NRTIs) and other drugs (mechanistic target of rapamycin inhibitors -mTORs, post organ transplantation drugs, tyrosine kinase inhibitors and interferon-alpha)...
October 2017: Maturitas
https://www.readbyqxmd.com/read/28921676/perioperative-passport-empowering-people-with-diabetes-along-their-surgical-journey
#13
E Page, F Akiboye, S Jackson, C Kerry, R Round, G Rayman
AIM: To determine whether a handheld 'perioperative passport' could improve the experience of perioperative care for people with diabetes and overcome some of the communication issues commonly identified in inpatient extracts. METHODS: Individuals with diabetes undergoing elective surgery requiring at least an overnight stay were identified via a customized information technology system. Those allocated to the passport group were given the perioperative passport before their hospital admission...
September 18, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28894635/topical-naltrexone-is-a-safe-and-effective-alternative-to-standard-treatment-of-diabetic-wounds
#14
Patricia J McLaughlin, Jarrett D Cain, Michelle B Titunick, Joseph W Sassani, Ian S Zagon
Objective: Diabetes affects more than 29 million individuals in the United States, resulting in healthcare costs approaching $245 billion. Approximately 15% of these individuals will develop a chronic, non-healing foot ulcer (diabetic foot ulcer [DFU]) that, if untreated, may lead to amputation. The current treatments for DFU are expensive, have significant side-effects, and often result in non-compliance. A new topical treatment is described that accelerates cutaneous wound repair and is disease modifying by targeting underlying aberrant diabetic pathways...
September 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28890661/association-of-angiotensin-converting-enzyme-gene-polymorphisms-and-nephropathy-in-diabetic-patients-at-a-tertiary-care-centre-in-south-india
#15
Mukta Wyawahare, Revathy Neelamegam, Saranya Vilvanathan, R Soundravally, A K Das, C Adithan
BACKGROUND: Genetic polymorphisms of the angiotensin-renin pathway have been thought to influence the development of diabetic nephropathy. However, there are conflicting results regarding this association in previous studies on populations with varying ethnicity. AIMS: Primary aim was to compare the frequency of distribution of angiotensin-converting enzyme (ACE) gene (insertion/deletion [I/D]) polymorphism in Tamilian Indian type 2 diabetic individuals with and without microalbuminuria...
2017: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/28870707/interventions-to-improve-%C3%AE-cell-mass-and-function
#16
Prosenjit Mondal, Amit Prasad, Khyati Girdhar
Diabetes mellitus (T2DM) has become an epidemiologically important disease worldwide and is also becoming a great matter of concern due to the effects associated with it like: high morbidity, elevated health care cost and shortened life span. T2DM is a chronic metabolic disease characterized by insulin resistance as well as β-cell dysfunction. It is widely accepted that in the face of insulin resistance, euglycemia can be maintained by increase in pancreatic β-cell mass and insulin secretion. This compensation is largely due to enhanced secretion of insulin by the β-cell mass, which is present initially, and thereby subsequent increases in β-cell mass provide additional insulin secretion...
September 1, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28852954/pressure-ulcers-are-associated-with-6-month-mortality-in-elderly-patients-with-hip-fracture-managed-in-orthogeriatric-care-pathway
#17
Emmanuelle Magny, Helene Vallet, Judith Cohen-Bittan, Mathieu Raux, Antony Meziere, Marc Verny, Bruno Riou, Frédéric Khiami, Jacques Boddaert
Despite orthogeriatric management, 12% of the elderly experienced PUs after hip fracture surgery. PUs were significantly associated with a low albumin level, history of atrial fibrillation coronary artery disease, and diabetes. The risk ratio of death at 6 months associated with pressure ulcer was 2.38 (95% CI 1.31-4.32%, p = 0.044). INTRODUCTION: Pressure ulcers in hip fracture patients are frequent and associated with a poor outcome. An orthogeriatric management, recommended by international guidelines in hip fracture patients and including pressure ulcer prevention and treatment, could influence causes and consequences of pressure ulcer...
August 29, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28851413/a-large-cluster-randomized-trial-of-outcome-based-pathways-to-improve-home-based-wound-care
#18
Merrick Zwarenstein, Salimah Shariff, Nicole Mittmann, Anita Stern, Katie N Dainty
BACKGROUND: Although not always recognized as a pressing health care problem, wounds are a common, complex and costly condition. The burden of treating wounds is growing rapidly due to increasing health care costs, an aging population and a sharp rise in the incidence of diabetes and obesity worldwide. The Integrated Client Care (ICC) Project was a multi-year initiative to develop and test a new, integrated model of wound care within the home care sector in Ontario, Canada to improve health outcomes for patients and decrease system costs...
August 29, 2017: Trials
https://www.readbyqxmd.com/read/28840487/revascularization-strategies-in-stemi-with-multivessel-disease-deciding-on-culprit-versus-complete-ad-hoc-or-staged
#19
REVIEW
Shalin Patel, Steven R Bailey
PURPOSE OF REVIEW: This review will address the clinical conundrum of those who may derive clinical benefit from complete revascularization of coronary stenosis that are discovered at the time of ST segment elevation myocardial infarction (STEMI). The decision to revascularize additional vessels with angiographic stenosis beyond the culprit lesion remains controversial, as does the timing of revascularization. RECENT FINDINGS: STEMI patients represent a high-risk patient population that have up to a 50% prevalence of multivessel disease...
August 24, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28836996/random-or-predictable-adoption-patterns-of-chronic-care-management-practices-in-physician-organizations
#20
Isomi M Miake-Lye, Emmeline Chuang, Hector P Rodriguez, Gerald F Kominski, Elizabeth M Yano, Stephen M Shortell
BACKGROUND: Theories, models, and frameworks used by implementation science, including Diffusion of Innovations, tend to focus on the adoption of one innovation, when often organizations may be facing multiple simultaneous adoption decisions. For instance, despite evidence that care management practices (CMPs) are helpful in managing chronic illness, there is still uneven adoption by physician organizations. This exploratory paper leverages this natural variation in uptake to describe inter-organizational patterns in adoption of CMPs and to better understand how adoption choices may be related to one another...
August 24, 2017: Implementation Science: IS
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