Masaharu Shinkai, Noriyuki Katsumata, Shinichi Kawai, Shoichi Kuyama, Osamu Sasaki, Yasuhiro Yanagita, Minoru Yoshida, Shima Uneda, Yasushi Tsuji, Hidenori Harada, Yasunori Nishida, Yasuhiro Sakamoto, Daisuke Himeji, Hitoshi Arioka, Kazuhiro Sato, Ryo Katsuki, Hiroki Shomura, Hideshi Nakano, Hideaki Ohtani, Kazutaka Sasaki, Takeshi Adachi
PURPOSE: We investigated whether twice-daily administration of a bilayer tablet formulation of tramadol (35% immediate-release [IR] and 65% sustained-release) is as effective as four-times-daily IR tramadol capsules for managing cancer pain. METHODS: This randomized, double-blind, double-dummy, active-comparator, non-inferiority study enrolled opioid-naïve patients using non-steroidal anti-inflammatory drugs or acetaminophen (paracetamol) to manage cancer pain and self-reported pain (mean value over 3 days ≥ 25 mm on a 100-mm visual analog scale [VAS])...
December 29, 2023: Supportive Care in Cancer