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https://www.readbyqxmd.com/read/28188930/microrna-135a-regulates-sodium-calcium-exchanger-gene-expression-and-cardiac-electrical-activity
#1
Eric Duong, Jiening Xiao, Xiao Yan Qi, Stanley Nattel
BACKGROUND: Complete atrioventricular block (CAVB) causes arrhythmogenic remodeling and increases the risk of Torsades de Pointes (TdP) arrhythmias. MicroRNAs (miRNAs) are key regulators of gene-expression that contribute to cardiac remodeling. OBJECTIVE: To assess miRNA changes after complete atrioventricular block (CAVB) and identify novel candidates potentially involved in arrhythmogenic cardiac remodeling. METHODS: CAVB was induced in mice via His bundle ablation...
February 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28123343/let-7a-is-an-antihypertrophic-regulator-in-the-heart-via-targeting-calmodulin
#2
Xin Zhou, Fei Sun, Shenjian Luo, Wei Zhao, Ti Yang, Guiye Zhang, Ming Gao, Renzhong Lu, You Shu, Wei Mu, Yanan Zhuang, Fengzhi Ding, Chaoqian Xu, Yanjie Lu
Background: MicroRNAs (miRNAs) have been emerged as important regulator in a multiple of cardiovascular disease, including arrhythmia, cardiac hypertrophy and fibrosis, and myocardial infarction. The aim of this study was to investigate whether miRNA let-7a has antihypertrophic effects in angiotensin II (AngII)-induced cardiac hypertrophy. Methods: Neonatal rat ventricular myocytes (NRVMs) were exposed to AngII for 36 h as a cellular model of hypertrophy; subcutaneous injection of AngII for 2 weeks was used to establish a mouse model of cardiac hypertrophy in vivo study...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28081514/role-of-mirna-1-in-regulating-connexin-43-in-ischemia-reperfusion-heart-injury-a-rat-model
#3
Bo Bian, Xue-Fang Yu, Guo-Qin Wang, Tian-Ming Teng
MiRNA-1 may participate in regulating ischemia-reperfusion injury (IRI) by affecting the expression and distribution of connexin 43 (Cx43). The aim of this study is to investigate miR-1 expression and its potential role in regulating Cx43 during ischemic postconditioning (IPOST) in a rat model. Fifty-five Wistar male rats were randomly divided into five groups: N, IR, IPOST, agomir-1, and antagomir-1 group. The hearts were perfused with the Langendorff system. The reperfusion arrhythmia (RA) and myocardial infarct size were observed and recorded...
January 3, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/27987400/an-insertion-deletion-polymorphism-within-3-utr-of-ryr2-modulates-sudden-unexplained-death-risk-in-chinese-populations
#4
Shouyu Wang, Zhixiang Zhang, Ya Yang, Chaoqun Wang, Ruiyang Tao, Shuxiang Hu, Zhixia Yin, Qing Zhang, Lijuan Li, Yan He, Shaohua Zhu, Chengtao Li, Suhua Zhang, Jianhua Zhang, Lihui Sheng, Fangyu Wu, Bin Luo, Yuzhen Gao
Sudden unexplained death (SUD) constitutes a part of the overall sudden death that can not be underestimated. Over the last years, genetic testing on SUD has revealed that inherited channelopathies might play important roles in the pathophysiology of this disease. Ryanodine receptor type-2 (RYR2) is a kind of ion channel extensively distributed in the sarcoplasmic reticulum (SR) of myocardium. Studies on RYR2 have suggested that either dysfunction or abnormal expression of it could lead to arrhythmia, which may cause cardiac arrest...
December 9, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27690014/new-treatment-strategies-for-alcohol-induced-heart-damage
#5
Joaquim Fernández-Solà, Ana Planavila Porta
High-dose alcohol misuse induces multiple noxious cardiac effects, including myocyte hypertrophy and necrosis, interstitial fibrosis, decreased ventricular contraction and ventricle enlargement. These effects produce diastolic and systolic ventricular dysfunction leading to congestive heart failure, arrhythmias and an increased death rate. There are multiple, dose-dependent, synchronic and synergistic mechanisms of alcohol-induced cardiac damage. Ethanol alters membrane permeability and composition, interferes with receptors and intracellular transients, induces oxidative, metabolic and energy damage, decreases protein synthesis, excitation-contraction coupling and increases cell apoptosis...
September 29, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27488468/oxidized-low-density-lipoprotein-ox-ldl-cholesterol-induces-the-expression-of-mirna-223-and-l-type-calcium-channel-protein-in-atrial-fibrillation
#6
Fengping He, Xin Xu, Shuguo Yuan, Liangqiu Tan, Lingjun Gao, Shaochun Ma, Shebin Zhang, Zhanzhong Ma, Wei Jiang, Fenglian Liu, Baofeng Chen, Beibei Zhang, Jungang Pang, Xiuyan Huang, Jiaqiang Weng
Atrial fibrillation (AF) is the most common sustained arrhythmia causing high morbidity and mortality. While changing of the cellular calcium homeostasis plays a critical role in AF, the L-type calcium channel α1c protein has suggested as an important regulator of reentrant spiral dynamics and is a major component of AF-related electrical remodeling. Our computational modeling predicted that miRNA-223 may regulate the CACNA1C gene which encodes the cardiac L-type calcium channel α1c subunit. We found that oxidized low-density lipoprotein (ox-LDL) cholesterol significantly up-regulates both the expression of miRNA-223 and L-type calcium channel protein...
August 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27422887/elevated-serum-microrna-483-5p-levels-may-predict-patients-at-risk-of-post-operative-atrial-fibrillation
#7
Leanne Harling, Jonathan Lambert, Hutan Ashrafian, Ara Darzi, Nigel J Gooderham, Thanos Athanasiou
OBJECTIVES: Post-operative atrial fibrillation (POAF) is the commonest post-operative cardiac arrhythmia, affecting ∼1 in 3 patients undergoing coronary artery bypass grafting (CABG). Although its aetiology is complex, atrial substrate changes may pre-dispose to its onset. This study aims to ascertain the atrial microRNA signature of POAF and determine the potential for circulating microRNA as a pre-operative biomarker for this arrhythmia. METHODS: Thirty-four patients undergoing non-emergent, on-pump CABG were prospectively recruited...
January 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27420053/micrornas-in-valvular-heart-diseases-potential-role-as-markers-and-actors-of-valvular-and-cardiac-remodeling
#8
REVIEW
Cécile Oury, Laurence Servais, Nassim Bouznad, Alexandre Hego, Alain Nchimi, Patrizio Lancellotti
miRNAs are a class of over 5000 noncoding RNAs that regulate more than half of the protein-encoding genes by provoking their degradation or preventing their translation. miRNAs are key regulators of complex biological processes underlying several cardiovascular disorders, including left ventricular hypertrophy, ischemic heart disease, heart failure, hypertension and arrhythmias. Moreover, circulating miRNAs herald promise as biomarkers in acute myocardial infarction and heart failure. In this context, this review gives an overview of studies that suggest that miRNAs could also play a role in valvular heart diseases...
July 13, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27322747/mir-223-3p-as-a-novel-microrna-regulator-of-expression-of-voltage-gated-k-channel-kv4-2-in-acute-myocardial-infarction
#9
Xue Liu, Ying Zhang, Weijie Du, Haihai Liang, Hua He, Lu Zhang, Zhenwei Pan, Xuelian Li, Chaoqian Xu, Yuhong Zhou, Leimin Wang, Ming Qian, Tianyi Liu, Hongli Yin, Yanjie Lu, Baofeng Yang, Hongli Shan
BACKGROUND/AIMS: Acute myocardial infarction (AMI) is a devastating cardiovascular disease with a high rate of morbidity and mortality, partly due to enhanced arrhythmogenicity. MicroRNAs (miRNAs) have been shown to participate in the regulation of cardiac ion channels and the associated arrhythmias. The purpose of this study was to test our hypothesis that miR-223-3p contributes to the electrical disorders in AMI via modulating KCND2, the gene encoding voltage-gated channel Kv4.2 that carries transient outward K+ current Ito...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27306406/p38-mapk-mir-1-are-involved-in-the-protective-effect-of-egcg-in-high-glucose-induced-cx43-downregulation-in-neonatal-rat-cardiomyocytes
#10
Lu Yu, Hongmei Yu, Xiaoting Li, Chongying Jin, Yanbo Zhao, Shengjie Xu, Xia Sheng
The remodeling of cardiac gap junctions contributes to various arrhythmias in a diabetic heart. We previously reported that Epigallocatechin-3-gallate (EGCG) attenuated connexin43 (Cx43) protein downregulation induced by high glucose (HG) in neonatal rat cardiomyocytes, but Cx43 mRNA expression was not affected. It indicated the possible mechanisms of post-transcriptional regulation, which still remains unclear. As microRNAs (miRNAs) regulate gene expression widely at post-transcriptional level, we measured miR-1/206 in cardiomyocytes treated with HG and EGCG by quantitative RT-PCR and investigated their relationship with signal transduction pathways...
August 2016: Cell Biology International
https://www.readbyqxmd.com/read/27213338/microrna-19b-downregulates-gap-junction-protein-alpha1-and-synergizes-with-microrna-1-in-viral-myocarditis
#11
Junyi Lin, Aimin Xue, Liliang Li, Beixu Li, Yuhua Li, Yiwen Shen, Ning Sun, Ruizhen Chen, Hongfei Xu, Ziqin Zhao
Viral myocarditis (VMC) is a life-threatening disease that leads to heart failure or cardiac arrhythmia. A large number of researches have revealed that mircroRNAs (miRNAs) participate in the pathological processes of VMC. We previously reported that miR-1 repressed the expression of gap junction protein α1 (GJA1) in VMC. In this study, miR-19b was found to be significantly upregulated using the microarray analysis in a mouse model of VMC, and overexpression of miR-19b led to irregular beating pattern in human cardiomyocytes derived from the induced pluripotent stem cells (hiPSCs-CMs)...
May 18, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27056419/cardiac-specific-mirna-in-cardiogenesis-heart-function-and-cardiac-pathology-with-focus-on-myocardial-infarction
#12
REVIEW
Dimitry A Chistiakov, Alexander N Orekhov, Yuri V Bobryshev
Cardiac miRNAs (miR-1, miR133a, miR-208a/b, and miR-499) are abundantly expressed in the myocardium. They play a central role in cardiogenesis, heart function and pathology. While miR-1 and miR-133a predominantly control early stages of cardiogenesis supporting commitment of cardiac-specific muscle lineage from embryonic stem cells and mesodermal precursors, miR-208 and miR-499 are involved in the late cardiogenic stages mediating differentiation of cardioblasts to cardiomyocytes and fast/slow muscle fiber specification...
May 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/26926467/micrornas-as-candidate-drug-targets-for-cardiovascular-diseases
#13
Pengzhou Hang, Jing Guo, Chuan Sun, Zhimin Du
MicroRNAs (miRNAs) are small conserved noncoding RNAs which function as post-transcriptional regulators of gene expression. Studies over the last 20 years have revealed the essential functions of miRNAs in regulating cardiovascular biology (such as cardiovascular cell differentiation, growth, proliferation and apoptosis) and crucial roles in controlling cardiovascular disease (CVD), indicating the potential of these small molecules as therapeutic targets and/or agents for CVD. Moreover, miRNAs in the circulation or other body fluids are stable and readily detectable, and more importantly often disease-associated, which makes them promising novel biomarkers for diagnosis and prognosis of CVDs...
February 29, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/26859843/micrornas-as-biomarkers-for-acute-atrial-remodeling-in-marathon-runners-the-mirathon-study-a-sub-study-of-the-munich-marathon-study
#14
Sebastian Clauss, Reza Wakili, Bianca Hildebrand, Stefan Kääb, Eva Hoster, Ina Klier, Eimo Martens, Alan Hanley, Henner Hanssen, Martin Halle, Thomas Nickel
INTRODUCTION: Physical activity is beneficial for individual health, but endurance sport is associated with the development of arrhythmias like atrial fibrillation. The underlying mechanisms leading to this increased risk are still not fully understood. MicroRNAs are important mediators of proarrhythmogenic remodeling and have potential value as biomarkers in cardiovascular diseases. Therefore, the objective of our study was to determine the value of circulating microRNAs as potential biomarkers for atrial remodeling in marathon runners (miRathon study)...
2016: PloS One
https://www.readbyqxmd.com/read/26835117/the-role-of-micrornas-in-antiarrhythmic-therapy-for-atrial-fibrillation
#15
Sebastian Clauss, Moritz F Sinner, Stefan Kääb, Reza Wakili
Atrial fibrillation (AF) is the most common arrhythmia worldwide and has an enormous impact on our healthcare system as it is a major contributor of morbidity and mortality. Although there are several therapeutic options available, treatment of AF still remains challenging. AF pathophysiology is complex and still incompletely understood. In general, our understanding of AF is based on two mechanistic paradigms as functional hallmarks of AF: ectopic activity and reentry. Both ectopic activity and reentry are the result of remodelling processes...
December 2015: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/26783232/pancr-the-pitx2-adjacent-noncoding-rna-is-expressed-in-human-left-atria-and-regulates-pitx2c-expression
#16
Shamone R Gore-Panter, Jeffrey Hsu, John Barnard, Christine S Moravec, David R Van Wagoner, Mina K Chung, Jonathan D Smith
BACKGROUND: Genome-wide studies reveal that genetic variants at chromosome 4q25 constitute the strongest locus associated with atrial fibrillation, the most frequent arrhythmia. However, the mechanisms underlying this association are unknown. Our goal is to find and characterize left atrial-expressed transcripts in the chromosome 4q25 atrial fibrillation risk locus that may play a role in atrial fibrillation pathogenesis. METHODS AND RESULTS: RNA sequencing performed on human left/right pairs identified an intergenic long noncoding RNA adjacent to the PITX2 gene, which we have named PANCR (PITX2 adjacent noncoding RNA)...
January 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/26671473/the-regulatory-function-of-microrna-1-in-arrhythmias
#17
REVIEW
Caixiu Liao, Yajun Gui, Yuan Guo, Danyan Xu
Arrhythmia, the basis of which is cardiomyocyte ion channel abnormalities, poses a serious threat to human health. A large number of studies have demonstrated that miRNA-1(miR-1) is involved in the occurrence of arrhythmia in many myocardial pathological conditions by post-transcriptionally regulating a variety of ion channels and proteins related to cardiac electrical activity. We aim at emphasizing the relationship between miR-1 and ion channels and proteins involved in the process of arrhythmia. In addition, we will pay attention to its future therapeutic prospects...
February 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/26503985/pivotal-role-of-mir-448-in-the-development-of-ros-induced-cardiomyopathy
#18
Sergii Kyrychenko, Viktoriia Kyrychenko, Myriam A Badr, Yoshiyuki Ikeda, Junichi Sadoshima, Natalia Shirokova
AIMS: Nicotinamide adenine dinucleotide oxidases (NOXs) are important contributors to cellular oxidative stress in the cardiovascular system. The NOX2 isoform is upregulated in numerous disorders, including dystrophic cardiomyopathy, where it drives the progression of the disease. However, mechanisms underlying NOX2 overexpression are still unknown. We investigated the role of microRNAs (miRs) in the regulation of NOX2 expression. METHODS AND RESULTS: Duchenne muscular dystrophy (DMD) was used as a model of cardiomyopathy...
December 1, 2015: Cardiovascular Research
https://www.readbyqxmd.com/read/26476318/hexabromocyclododecane-exposure-induces-cardiac-hypertrophy-and-arrhythmia-by-inhibiting-mir-1-expression-via-up-regulation-of-the-homeobox-gene-nkx2-5
#19
Meifang Wu, Di Wu, Chonggang Wang, Zhizhun Guo, Bowen Li, Zhenghong Zuo
Hexabromocyclododecane (HBCD) is one of the most widely used brominated flame retardants. Although studies have reported that HBCD can cause a wide range of toxic effects on animals including humans, limited information can be found about its cardiac toxicity. In the present study, zebrafish embryos were exposed to HBCD at low concentrations of 0, 2, 20 and 200 nM. The results showed that HBCD exposure could induce cardiac hypertrophy and increased deposition of collagen. In addition, disordered calcium (Ca(2+)) handling was observed in H9C2 rat cardiomyocyte cells exposed to HBCD...
January 25, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/26221607/micrornas-novel-players-in-aortic-aneurysm
#20
REVIEW
Xian-ming Fu, Yang-zhao Zhou, Zhao Cheng, Xiao-bo Liao, Xin-min Zhou
An aortic aneurysm (AA) is a common disease with potentially life-threatening complications. Despite significant improvements in the diagnosis and treatment of AA, the associated morbidity and mortality remain high. MicroRNAs (miRNAs, miR) are small noncoding ribonucleic acids that negatively regulate gene expression at the posttranscriptional level by inhibiting mRNA translation or promoting mRNA degradation. miRNAs are recently reported to be critical modulators for vascular cell functions such as cell migration, contraction, differentiation, proliferation, and apoptosis...
2015: BioMed Research International
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