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https://www.readbyqxmd.com/read/27830156/administration-of-traditional-chinese-blood-circulation-activating-drugs-for-microvascular-complications-in-patients-with-type-2-diabetes-mellitus
#1
REVIEW
Lisha He, Han Wang, Chengjuan Gu, Xinhui He, Linhua Zhao, Xiaolin Tong
Traditional Chinese medicine (TCM) is an important complementary strategy for treating diabetes mellitus (DM) in China. Traditional Chinese blood circulation activating drugs are intended to guide an overall approach to the prevention and treatment of microvascular complications of DM. The core mechanism is related to the protection of the vascular endothelium and the basement membrane. Here, we reviewed the scientific evidence underpinning the use of blood circulation activating drugs to prevent and treat DM-induced microvascular complications, including diabetic nephropathy (DN), diabetic peripheral neuropathy (DPN), and diabetic retinopathy (DR)...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27782944/chronic-sciatic-neuropathy-in-rat-reduces-voluntary-wheel-running-activity-with-concurrent-chronic-mechanical-allodynia
#2
Ryan A Whitehead, Nicholas L Lam, Melody S Sun, Joshua Sanchez, Shahani Noor, Arden G Vanderwall, Timothy R Petersen, Hugh B Martin, Erin D Milligan
BACKGROUND: Animal models of peripheral neuropathy produced by a number of manipulations are assessed for the presence of pathologic pain states such as allodynia. Although stimulus-induced behavioral assays are frequently used and important to examine allodynia (ie, sensitivity to light mechanical touch; von Frey fiber test), other measures of behavior that reflect overall function are not only complementary to stimulus-induced responsive measures, but are also critical to gain a complete understanding of the effects of the pain model on quality of life, a clinically relevant aspect of pain on general function...
October 24, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27763908/ultrasonographic-and-surgical-findings-of-acute-radial-neuropathy-following-blunt-trauma
#3
Seok-Youl Choi, Jong Woong Park, Dong Hwee Kim
Ultrasonographic study is useful for decision making of treatment for focal neuropathy with unusual electrodiagnostic findings. We present a patient with severe acute radial neuropathy with sensory sparing around the distal arm secondary to twisting of the radial nerve following blunt trauma. A 24-year-old man with a 2-week history of left wrist drop and severe pain around the left elbow presented after hitting the left distal arm on the doorknob. The left wrist and finger extensions were grade 0, but elbow extension could not be tested because of severe pain during this action...
November 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27740993/ultrasound-in-neurology
#4
Georgios Tsivgoulis, Andrei V Alexandrov
PURPOSE OF REVIEW: Low cost, avoidance of irradiation, and high temporal resolution are inherent advantages of ultrasound imaging that translate into multiple clinical uses in many domains of neurology. This article presents clinical uses of ultrasound examination in cerebrovascular, neurodegenerative, and peripheral nervous system diseases. RECENT FINDINGS: Modern treatment and prevention of ischemic stroke rely on prompt diagnosis. Ultrasonography has found a place as a noninvasive screening test and bedside technique that provides estimates of the degree of stenosis as well as hemodynamic and structural information about intracranial and extracranial vessels in real time...
October 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27638136/between-genetics-and-biology-is-enmg-useful-in-peripheral-neuropathy-diagnosis-and-management
#5
E Stålberg
Neurography and EMG are complementary techniques used in the diagnosis and monitoring of neuropathies. Both assess function of the peripheral nervous system and provide clinically useful information regarding the functional status of peripheral nerves. This information is not readily obtainable using biochemical, genetic or imaging techniques. I will discuss the role of these techniques in the diagnosis and management of neuropathies and some limitations of these techniques. These methods are routinely used in an EMG lab...
October 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27358589/acupuncture-could-it-become-everyday-practice-in-oncology
#6
REVIEW
Aneta Kilian-Kita, Mirosława Puskulluoglu, Kamil Konopka, Krzysztof Krzemieniecki
Acupuncture is a complementary and alternative medical treatment (CAM) which is increasingly used in the care of cancer patients. Traditionally derived from Chinese medicine, nowadays it is becoming a part of evidence-based oncology. The use of acupuncture in these patients has been recommended by the American Cancer Society (ACS) for the treatment of side effects associated with conventional cancer therapy and cancer-related ailments. A growing body of evidence supports the use of acupuncture in the treatment of cancer-induced pain and chemotherapy-related nausea and vomiting...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/27246283/recent-advances-in-diagnostic-strategies-for-diabetic-peripheral-neuropathy
#7
REVIEW
Jong Chul Won, Tae Sun Park
Diabetes is an increasing epidemic in Korea, and associated diabetic peripheral neuropathy (DPN) is its most common and disabling complication. DPN has an insidious onset and heterogeneous clinical manifestations, making it difficult to detect high-risk patients of DPN. Early diagnosis is recommended and is the key factor for a better prognosis and preventing diabetic foot ulcers, amputation, or disability. However, diagnostic tests for DPN are not clearly established because of the various pathophysiology developing from the nerve injury to clinical manifestations, differences in mechanisms according to the type of diabetes, comorbidities, and the unclear natural history of DPN...
June 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27113066/-clinical-features-and-diagnosis-of-pelizaeus-merzbacher-disease-five-case-reports
#8
E Espinosa, P R Mera-Solarte, J E Cote-Orozco
INTRODUCTION: Pelizaeus-Merzbacher disease is an infrequent hypomyelinating disorder caused by alterations in the PLP1 gene, which leads to a fault in the axonal myelination of the oligodendrocytes in the central nervous system. Two forms have been reported, according to the severity of the presentation: connatal and classic. It is characterised by neonatal hypotonia, delayed psychomotor development, progressive spasticity predominantly in the lower limbs and nystagmus, with pyramidal and extrapyramidal signs and symptoms; the connatal form is far more severe...
May 1, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27088476/ultrasonographic-and-surgical-findings-of-acute-radial-neuropathy-following-blunt-trauma-a-case-report
#9
Seok-Youl Choi, Jong Woong Park, Dong Hwee Kim
Ultrasonographic study is useful for decision making of treatment for focal neuropathy with unusual electrodiagnostic findings. We present a patient with severe acute radial neuropathy with sensory sparing around the distal arm secondary to twisting of the radial nerve following blunt trauma. A 24-year-old man with a 2-week history of left wrist drop and severe pain around the left elbow presented after hitting the left distal arm on the doorknob. The left wrist and finger extensions were grade 0, but elbow extension could not be tested because of severe pain during this action...
April 15, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/26652982/natural-products-and-complementary-therapies-for-chemotherapy-induced-peripheral-neuropathy-a-systematic-review
#10
REVIEW
Cloé Brami, Ting Bao, Gary Deng
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious dose-limiting side-effect without any FDA-approved treatment option. Prior reviews focus mostly on pharmacological interventions, but nonpharmaceutical interventions have also been evaluated. A Web of Science and PubMed database search to identify relevant RCTs from January 2005 to May 2015 included the terms: CIPN, cancer; and supplements, vitamin E, goshajinkigan, kampo, acetyl-L-carnitine, carnitine, alpha-lipoic acid, omega-3, glutamine, or glutamate; or massage, acupuncture, mind-body practice, yoga, meditation, Tai-Chi, physical activity, or exercise...
February 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/26485261/targeting-neuropathic-pain-consider-these-alternatives
#11
REVIEW
Mary Onysko, Presley Legerski, Jessica Potthoff, Michael Erlandson
When patients with painful peripheral neuropathy fail to respond to--or are unable to tolerate--standard therapies, consider these lesser-known treatments.
August 2015: Journal of Family Practice
https://www.readbyqxmd.com/read/26331047/peripheral-nerve-axonal-excitability-studies-expanding-the-neurophysiologist-s-armamentarium
#12
William Huynh, Matthew C Kiernan
Nerve excitability studies have emerged as a recent novel non-invasive technique that offers complementary information to that provided by more conventional nerve conduction studies, the latter which provide only limited indices of peripheral nerve function. Such novel tools allow for the assessment of peripheral axonal biophysical properties that include ion channels, energy-dependent pumps and membrane potential in health and disease. With improvements in technique and development of protocols, a typical study can be completed in a short period of time and rapid measurement of multiple excitability indices can be achieved that provide insight into different aspects of peripheral nerve function...
2015: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/26315368/evaluation-of-extensor-digitorum-brevis-thickness-in-healthy-subjects-a-comparative-analysis-of-nerve-conduction-studies-and-ultrasound-scans
#13
COMPARATIVE STUDY
Jung Im Seok, Francis O Walker, Sang Gyu Kwak
OBJECTIVES: (1) To evaluate the relationship between the thickness and compound muscle action potential (CMAP) of the extensor digitorum brevis (EDB) muscle; (2) to obtain reference values for distal lower extremity muscle thickness as a possible measure of peripheral neuropathy; and (3) to evaluate various factors associated with unexplained EDB atrophy. METHODS: We measured the thickness of EDB, abductor hallucis brevis (AHB) and tibialis anterior (TA) muscles in 80 healthy volunteers with ultrasound and assessed EDB CMAP with fibular nerve stimulation...
February 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/26019423/comparison-of-high-resolution-sonography-and-electrophysiology-in-the-diagnosis-of-carpal-tunnel-syndrome
#14
Meena Angamuthu Kanikannan, Demudu Babu Boddu, Umamahesh, Sailaja Sarva, Padmaja Durga, Rupam Borgohain
BACKGROUND: The diagnostic accuracy of high-resolution ultrasonography (HRUS) in comparison to electro-diagnostic testing (EDX) in carpal tunnel syndrome (CTS) is debatable. OBJECTIVE: The aim of this study was to compare the diagnostic accuracy of HRUS with EDX in patients with various grades of CTS and CTS associated with peripheral neuropathy (CTS + PNP). MATERIALS AND METHODS: A prospective cohort of 57 patients with possible CTS was studied along with matched controls...
April 2015: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/25957985/somatosensory-evoked-potentials-in-the-assessment-of-peripheral-neuropathies-commented-results-of-a-survey-among-french-speaking-practitioners-and-recommendations-for-practice
#15
R Morizot-Koutlidis, N André-Obadia, J-C Antoine, S Attarian, S S Ayache, E Azabou, S Benaderette, J-P Camdessanché, J Cassereau, P Convers, J d'Anglejean, A Delval, M-C Durand, O Etard, G Fayet, E Fournier, J Franques, M Gavaret, D Guehl, J-M Guerit, E Krim, N Kubis, A Lacour, P Lozeron, F Mauguière, P-E Merle, F Mesrati, V Mutschler, G Nicolas, T Nordine, V Pautot, Y Péréon, P Petiot, J Pouget, J Praline, H Salhi, A Trébuchon, L Tyvaert, C Vial, J-M Zola, J Zyss, J-P Lefaucheur
BACKGROUND: Somatosensory evoked potentials (SSEPs) are increasingly performed for the assessment of peripheral neuropathies, but no practical guidelines have yet been established in this specific application. STUDY AIM: To determine the relevant indication criteria and optimal technical parameters for SSEP recording in peripheral neuropathy investigation. METHODS: A survey was conducted among the French-speaking practitioners with experience of SSEP recording in the context of peripheral neuropathies...
May 2015: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/25788678/nociceptor-beta-ii-delta-and-epsilon-isoforms-of-pkc-differentially-mediate-paclitaxel-induced-spontaneous-and-evoked-pain
#16
Ying He, Zaijie Jim Wang
As one of the most effective and frequently used chemotherapeutic agents, paclitaxel produces peripheral neuropathy (paclitaxel-induced peripheral neuropathy or PIPN) that negatively affects chemotherapy and persists after cancer therapy. The mechanisms underlying this dose-limiting side effect remain to be fully elucidated. This study aimed to investigate the role of nociceptor protein kinase C (PKC) isoforms in PIPN. Employing multiple complementary approaches, we have identified a subset of PKC isoforms, namely βII, δ, and ϵ, were activated by paclitaxel in the isolated primary afferent sensory neurons...
March 18, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/25653385/ultrasound-in-the-diagnosis-of-peripheral-neuropathy-structure-meets-function-in-the-neuromuscular-clinic
#17
REVIEW
Elena Gallardo, Yu-Ichi Noto, Neil G Simon
Peripheral nerve ultrasound (US) has emerged as a promising technique for the diagnosis of peripheral nerve disorders. While most experience with US has been reported in the context of nerve entrapment syndromes, the role of US in the diagnosis of peripheral neuropathy (PN) has recently been explored. Distinctive US findings have been reported in patients with hereditary, immune-mediated, infectious and axonal PN; US may add complementary information to neurophysiological studies in the diagnostic work-up of PN...
October 2015: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/25620065/nerve-ultrasound-in-a-case-of-multifocal-motor-neuropathy-without-conduction-block
#18
Kalliopi Pitarokoili, Ralf Gold, Min-Suk Yoon
INTRODUCTION: Multifocal nerve enlargements and ultrastructural changes either corresponding or not to sites of existing conduction blocks have been described in demyelinating polyneuropathies using multiple imaging techniques. METHODS: Using the emerging technique of peripheral nerve ultrasonography we investigated the peripheral nerves of a patient with multifocal motor neuropathy (MMN) without conduction block. RESULTS: In this case of MMN without conduction blocks we found multifocal nerve enlargements in the ultrasonography and electrodiagnostic signs of acute and chronic denervation associated with positive anti-GM1 IgM antibodies...
August 2015: Muscle & Nerve
https://www.readbyqxmd.com/read/25347605/is-mycophenolate-mofetil-an-alternative-agent-to-corticosteroids-in-traumatic-nerve-paralysis
#19
RANDOMIZED CONTROLLED TRIAL
Savaş Korlu, Yusuf Vayisoglu, Ulku Comelekoglu, Savas Aktas, Rabia Bozdogan Arpaci, Serap Yalin, Ahmet Dagtekin, Lokman Ayaz, Ozlen Tubay Bagdatoğlu, Damla Koca, Hasan Basri Kirbas, Bahar Tasdelen, Derya Umit Talas
OBJECTIVE: The effects of an immunosuppressive agent, mycophenolate mofetil (MM), were investigated and compared with those of methylprednisolone (MP) and dexamethasone (DXM) on the traumatic nerve function. STUDY DESIGN: This is a randomized controlled animal study. MATERIALS AND METHODS: This experimental study was performed on 84 male Wistar albino rats. The rats were assigned to 12 groups each consisting of 7 animals. The groups were formed according to application of normal-dose DXM (group 1A-B), high-dose MP (group 2A-B), normal-dose MP (group 3A-B), MM (group 4A-B), and MM with high-dose MP combination therapies (group VA-B)...
November 2014: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/25239074/role-of-the-trek2-potassium-channel-in-cold-and-warm-thermosensation-and-in-pain-perception
#20
Vanessa Pereira, Jérôme Busserolles, Marine Christin, Maïly Devilliers, Laura Poupon, Wassim Legha, Abdelkrim Alloui, Youssef Aissouni, Emmanuel Bourinet, Florian Lesage, Alain Eschalier, Michel Lazdunski, Jacques Noël
Two-pore domain background K(+) channels (K2p or KCNK) produce hyperpolarizing currents that control cell membrane polarity and neuronal excitability throughout the nervous system. The TREK2 channel as well as the related TREK1 and TRAAK channels are mechanical-, thermal- and lipid-gated channels that share many regulatory properties. TREK2 is one of the major background channels expressed in rodent nociceptive neurons of the dorsal root ganglia that innervate the skin and deep body tissues, but its role in somatosensory perception and nociception has remained poorly understood...
December 2014: Pain
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