keyword
https://read.qxmd.com/read/38535945/long-term-environmental-methylmercury-exposure-is-associated-with-peripheral-neuropathy-and-cognitive-impairment-among-an-amazon-indigenous-population
#1
JOURNAL ARTICLE
Bruno H Rebouças, Gabriel T Kubota, Rogério A A Oliveira, Bruna D Pinto, Roberta M Cardoso, Ana C S Vasconcellos, Paulo C Basta
Widespread contamination of the Amazon basin with mercury has been reported to occur since at least the mid-80s due to heavy gold mining activity. Although initial studies have indicated that this may lead to deleterious neurological consequences to the indigenous populations living in the region, further research is needed to better characterize the neurological burden of such long-term exposure. With this aim, a cross-sectional exploratory study has been conducted with the Yanomami indigenous population residing in a northern Amazon region...
March 12, 2024: Toxics
https://read.qxmd.com/read/38534355/recent-research-trends-in-neuroinflammatory-and-neurodegenerative-disorders
#2
REVIEW
Jessica Cohen, Annette Mathew, Kirk D Dourvetakis, Estella Sanchez-Guerrero, Rajendra P Pangeni, Narasimman Gurusamy, Kristina K Aenlle, Geeta Ravindran, Assma Twahir, Dylan Isler, Sara Rukmini Sosa-Garcia, Axel Llizo, Alison C Bested, Theoharis C Theoharides, Nancy G Klimas, Duraisamy Kempuraj
Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions of these disease pathogeneses is currently not clearly understood. These disorders show dysregulated neuroimmune and inflammatory responses, including activation of neurons, glial cells, and neurovascular unit damage associated with excessive release of proinflammatory cytokines, chemokines, neurotoxic mediators, and infiltration of peripheral immune cells into the brain, as well as entry of inflammatory mediators through damaged neurovascular endothelial cells, blood-brain barrier and tight junction proteins...
March 14, 2024: Cells
https://read.qxmd.com/read/38516041/post-translational-modifications-of-beta-amyloid-alter-its-transport-in-the-blood-brain-barrier-in-vitro-model
#3
JOURNAL ARTICLE
Kseniya B Varshavskaya, Irina Yu Petrushanko, Vladimir A Mitkevich, Evgeny P Barykin, Alexander A Makarov
One of the hallmarks of Alzheimer's disease (AD) is the accumulation of beta-amyloid peptide (Aβ) leading to formation of soluble neurotoxic Aβ oligomers and insoluble amyloid plaques in various parts of the brain. Aβ undergoes post-translational modifications that alter its pathogenic properties. Aβ is produced not only in brain, but also in the peripheral tissues. Such Aβ, including its post-translationally modified forms, can enter the brain from circulation by binding to RAGE and contribute to the pathology of AD...
2024: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/38498731/car19-monitoring-by-peripheral-blood-immunophenotyping-reveals-histology-specific-expansion-and-toxicity
#4
JOURNAL ARTICLE
Mark P Hamilton, Erin Craig, Cesar Gentille Sanchez, Alain Mina, John Tamaresis, Nadia Kirmani, Zachary Ehlinger, Shriya Syal, Zinaida Good, Brian Sworder, Joseph Schroers-Martin, Ying Lu, Lori Muffly, Robert S Negrin, Sally Arai, Robert Lowsky, Everett Meyer, Andrew R Rezvani, Judith A Shizuru, Wen-Kai Weng, Parveen Shiraz, Surbhi Sidana, Sushma Bharadwaj, Melody Smith, Saurabh Dahiya, Bita Sahaf, David M Kurtz, Crystal L Mackall, Robert Tibshirani, Ash A Alizadeh, Matthew J Frank, David B Miklos
Chimeric antigen receptor (CAR) T cells directed against CD19 (CAR19) are a revolutionary treatment for B-cell lymphomas. CAR19 cell expansion is necessary for CAR19 function but is also associated with toxicity. To define the impact of CAR19 expansion on patient outcomes, we prospectively followed a cohort of 236 patients treated with CAR19 (brexucabtagene autoleucel or axicabtagene ciloleucel) for mantle cell (MCL), follicular (FL), and large B-cell lymphoma (LBCL) over the course of five years and obtained CAR19 expansion data using peripheral blood immunophenotyping for 188 of these patients...
March 18, 2024: Blood Advances
https://read.qxmd.com/read/38469410/neuropredict-study-of-the-predictive-value-of-abcb1-genetic-polymorphisms-and-associated-clinical-factors-in-chronic-chemotherapy-induced-peripheral-neuropathy-cipn
#5
JOURNAL ARTICLE
Alicia Vargas-Aliaga, María De la Haba, María José Contreras, Cristina Morales Estevez, Ignacio Porras, María Teresa Cano, Gema Pulido, María Auxiliadora Gómez, Pablo Flores-Paco, De La Haba-Rodriguez Juan, Enrique Aranda
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common entity (30%-40%) and can significantly limit the quality of life of patients, especially those that persist for more than 6 months after treatment (chronic neuropathy). Studies have shown a possible association between the presence of genetic polymorphisms in ABCB1 and the development of acute CIPN, although this relationship with chronic CIPN remains unexplored. This is an analytical observational case-control study defined by the presence (cases) or absence (controls) of CIPN at 6 months after the end of the neurotoxic drug...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38467790/neurological-autoimmunity-in-melanoma-patients-a-comparison-between-those-exposed-and-non-exposed-to-immune-checkpoint-inhibitors
#6
JOURNAL ARTICLE
Andreu Vilaseca, Antonio Farina, Macarena Villagrán-García, Antoine Pegat, Marie Benaiteau, Nicolás Lundahl Ciano-Petersen, Le-Duy Do, Véronique Rogemond, David Gonçalves, Dimitri Psimaras, Cristina Birzu, Jérôme Honnorat, Bastien Joubert
BACKGROUND: The clinical spectrum of melanoma-associated neurological autoimmunity, whether melanoma-associated paraneoplastic neurological syndromes (PNS) or induced by immune checkpoint inhibitors (ICI), is not well characterized. We aim to describe the clinical spectrum of melanoma-associated neurological autoimmunity. METHODS: A systematic review of the literature combined with patients from French databases of paraneoplastic neurological syndromes was conducted...
March 11, 2024: Journal of Neurology
https://read.qxmd.com/read/38466644/biomarkers-of-efficacy-and-safety-of-the-academic-bcma-cart-ari0002h-for-the-treatment-of-refractory-multiple-myeloma
#7
JOURNAL ARTICLE
Aina Oliver-Caldés, Marta Español-Rego, Aintzane Zabaleta, Veronica Gonzalez-Calle, Sergio Navarro-Velázquez, Susana Inoges, Ascensión López-Díaz de Cerio, Valentin Cabañas, Nieves López-Muñoz, Paula Rodriguez-Otero, Juan Luis Reguera-Ortega, David F Moreno, Núria Martínez-Cibrian, Lucía López-Corral, Lorena Pérez-Amill, Beatriz Martin-Antonio, Laura Rosinol, Joan Cid, Natalia Tovar, Joaquin Saez-Peñataro, Miriam Lopez-Parra, Eulalia Olesti, Elena Guillen, Sara Varea, Luis Gerardo Rodríguez-Lobato, Anthony M Battram, Marta-Sonia Gonzalez-Perez, Andres Sanchez-Salinas, Azucena González-Navarro, Valentin Ortiz-Maldonado, Julio Delgado, Felipe Prosper, Manel Juan, Joaquin Martinez-Lopez, Jose M Moraleda, Maria Victoria Mateos, Alvaro Urbano-Ispizua, Bruno Paiva, Mariona Pascal, Carlos Fernández de Larrea
BACKGROUND: BCMA-CARTs improve results obtained with conventional therapy in the treatment of relapsed/refractory multiple myeloma. However, the high demand and expensive costs associated with CART therapy might prove unsustainable for health systems. Academic CARTs could potentially overcome these issues. Moreover, response biomarkers and resistance mechanisms need to be identified and addressed to improve efficacy and patient selection. Here, we present clinical and ancillary results of the 60 patients treated with the academic BCMA-CART, ARI0002h, in the CARTBCMA-HCB-01 trial...
March 11, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38464172/the-primary-cilium-and-its-hedgehog-signaling-in-nociceptors-contribute-to-inflammatory-and-neuropathic-pain
#8
Kerry Tucker, Lindsey Fitzsimons, Larissa Staurengo-Ferrari, Oliver Bogen, Dioneia Araldi, Ivan Bonet, Ethan Jordan, Jon Levine
The primary cilium, a 1-3 μm long hair-like structure protruding from the surface of almost all cells in the vertebrate body, is critical for neuronal development and also functions in the adult. As the migratory neural crest settles into dorsal root ganglia (DRG) sensory neurons elaborate a single primary cilium at their soma that is maintained into adult stages. While it is not known if primary cilia are expressed in nociceptors, or their potential function in the mature DRG neuron, recent studies have shown a role for Hedgehog, whose signaling demonstrates a dependence on primary cilia, in nociceptor sensitization...
February 26, 2024: Research Square
https://read.qxmd.com/read/38459770/inflammation-in-obsessive-compulsive-disorder-a-literature-review-and-hypothesis-based-potential-of-transcranial-photobiomodulation
#9
REVIEW
David Richer Araujo Coelho, Joshua D Salvi, Willians Fernando Vieira, Paolo Cassano
Obsessive-compulsive disorder (OCD) is a disabling neuropsychiatric disorder that affects about 2%-3% of the global population. Despite the availability of several treatments, many patients with OCD do not respond adequately, highlighting the need for new therapeutic approaches. Recent studies have associated various inflammatory processes with the pathogenesis of OCD, including alterations in peripheral immune cells, alterations in cytokine levels, and neuroinflammation. These findings suggest that inflammation could be a promising target for intervention...
March 2024: Journal of Neuroscience Research
https://read.qxmd.com/read/38451915/%C3%AE-amyloid-peptide-modulates-peripheral-immune-responses-and-neuroinflammation-in-rats
#10
JOURNAL ARTICLE
Krishnendu Adhikary, Satyajit Mohanty, Bidyut Bandyopadhyay, Rajkumar Maiti, Koushik Bhattacharya, Prithviraj Karak
Alzheimer's disease (AD) is characterized by immune system dysregulation, impacting both central and peripheral immune responses. The study aimed to investigate the mechanism behind the neurotoxic effects of β-amyloid (Aβ) peptide in the rat brain including the study of neuroinflammation, neurodegeneration, and alterations in peripheral immune responses (PIR). The neuroinflammation brought on by Aβ1-42 and is unknown to influence PIR. Animal models were prepared, after 28 days, control, sham, and treated rats were anaesthetized and inflammatory markers of hippocampus and serum levels (reactive oxygen species, nitrite, tumor necrosis factor-α, and interleukin-1β), and some markers of PIR (splenic mononuclear cells or MNC, cytotoxicity and phagocytic index of the white blood cells leukocyte adhesion inhibition index or LAI), as well as polymorphonuclear cells of the spleen, were assessed...
January 1, 2024: Biomolecular Concepts
https://read.qxmd.com/read/38450073/neuroinflammation-and-acquired-traumatic-cns-injury-a-mini-review
#11
REVIEW
Michelle H Theus
Acquired traumatic central nervous system (CNS) injuries, including traumatic brain injury (TBI) and spinal cord injury (SCI), are devastating conditions with limited treatment options. Neuroinflammation plays a pivotal role in secondary damage, making it a prime target for therapeutic intervention. Emerging therapeutic strategies are designed to modulate the inflammatory response, ultimately promoting neuroprotection and neuroregeneration. The use of anti-inflammatory agents has yielded limited support in improving outcomes in patients, creating a critical need to re-envision novel approaches to both quell deleterious inflammatory processes and upend the progressive cycle of neurotoxic inflammation...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38437959/ursolic-acid-alleviates-paclitaxel-induced-peripheral-neuropathy-through-ppar%C3%AE-activation
#12
JOURNAL ARTICLE
Yulian Yang, Zhongzheng He, Shuangchan Wu
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) reduces the overall quality of life and leads to interruption of chemotherapy. Ursolic acid, a triterpenoid naturally which presents in fruit peels and in many herbs and spices, can function as a peroxisome proliferator-activated receptor γ (PPARγ) agonist, and has been widely used as an herbal medicine with a wide spectrum of pharmacological activities, including anti-cancer, anti-inflammatory and neuroprotective effect...
March 2, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38436780/silica-nanoparticles-decrease-glutamate-uptake-in-blood-brain-barrier-components
#13
JOURNAL ARTICLE
Fredy Sánchez-Cano, Luisa C Hernández-Kelly, Arturo Ortega
Glutamate is the major excitatory amino acid in the vertebrate brain, playing an important role in most brain functions. It exerts its activity through plasma membrane receptors and transporters, expressed both in neurons and glia cells. Overstimulation of neuronal glutamate receptors is linked to cell death in a process known as excitotoxicity, that is prevented by the efficient removal of the neurotransmitter through glutamate transporters enriched in the glia plasma membrane and in the components of the blood-brain barrier (BBB)...
March 4, 2024: Neurotoxicity Research
https://read.qxmd.com/read/38428887/efficacy-of-the-traditional-chinese-medicine-buyang-huanwu-decoction-at-preventing-taxane-induced-peripheral-neuropathy-in-breast-cancer-patients-a-prospective-randomized-controlled-study
#14
JOURNAL ARTICLE
Fan Luo, Donggui Wan, Jun Liu, Dongmei Chen, Mengqi Yuan, Chenyang Zhang, Qing Liu
BACKGROUND: Buyang Huanwu Decoction (BYHWD) is a traditional Chinese prescription, originally derived from Yi Lin Gai Cuo during the Qing Dynasty. This study aimed to evaluate the efficacy and safety of BYHWD in the prevention of taxane-induced peripheral neuropathy (TIPN) in patients with breast cancer. METHODS: This single-center, statistician-blinded, parallel-group, simple randomized, no-treatment controlled study was conducted at the China-Japan Friendship Hospital in Beijing...
March 1, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38423763/single-cell-analysis-of-rohon-beard-neurons-implicates-fgf-signaling-in-axon-maintenance-and-cell-survival
#15
JOURNAL ARTICLE
Adam M Tuttle, Lauren N Miller, Lindsey J Royer, Hua Wen, Jimmy J Kelly, Nicholas L Calistri, Laura M Heiser, Alex V Nechiporuk
Peripheral sensory neurons are a critical part of the nervous system that transmit a multitude of sensory stimuli to the central nervous system. During larval and juvenile stages in zebrafish, this function is mediated by Rohon-Beard somatosensory neurons (RBs). RBs are optically accessible and amenable to experimental manipulation, making them a powerful system for mechanistic investigation of sensory neurons. Previous studies provided evidence that RBs fall into multiple subclasses; however, the number and molecular make up of these potential RB subtypes have not been well defined...
February 29, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38419365/peripheral-nervous-system-and-neuromuscular-disorders-in-the-emergency-department-a-review
#16
JOURNAL ARTICLE
Ajith Sivadasan, Miguel A Cortel-LeBlanc, Achelle Cortel-LeBlanc, Hans Katzberg
INTRODUCTION: Acute presentations and emergencies in neuromuscular disorders (NMDs) often challenge clinical acumen. The objective of this review is to refine the reader's approach to history taking, clinical localization and early diagnosis, as well as emergency management of neuromuscular emergencies. METHODS: An extensive literature search was performed to identify relevant studies. We prioritized meta-analysis, systematic reviews, and position statements where possible to inform any recommendations...
February 28, 2024: Academic Emergency Medicine
https://read.qxmd.com/read/38419079/human-serum-derived-%C3%AE-synuclein-auto-antibodies-mediate-nmda-receptor-dependent-degeneration-of-cns-neurons
#17
JOURNAL ARTICLE
Pretty Garg, Franziska Würtz, Fabian Hobbie, Klemens Buttgereit, Abhishek Aich, Kristian Leite, Peter Rehling, Sebastian Kügler, Mathias Bähr
BACKGROUND: Presence of autoantibodies against α-synuclein (α-syn AAb) in serum of the general population has been widely reported. That such peripheral factors may be involved in central nervous system pathophysiology was demonstrated by detection of immunoglobulins (IgGs) in cerebrospinal fluid and brain of Parkinson's disease (PD) patients. Thus, blood-borne IgGs may reach the brain parenchyma through an impaired blood-brain barrier (BBB). FINDINGS: The present study aims to evaluate the patho-physiological impact of α-syn AAbs on primary brain cells, i...
February 28, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38399359/netazepide-an-antagonist-of-cholecystokinin-type-2-receptor-prevents-vincristine-induced-sensory-neuropathy-in-mice
#18
JOURNAL ARTICLE
Amandine Bernard, Mohamad Mroué, Sylvie Bourthoumieu, Malcolm Boyce, Laurence Richard, Franck Sturtz, Claire Demiot, Aurore Danigo
Among the vinca-alkaloid class, vincristine is a potent chemotherapeutic agent with significant neurotoxic effects and is employed to address a wide spectrum of cancer types. Recently, the therapeutic potential of the cholecystokinin type 2 receptor (CCK2R) as a target for vincristine-induced peripheral neuropathy (VIPN) was demonstrated. In this study, the impact of preventive CCK2R blockade using netazepide (Trio Medicines Ltd., London, UK) was investigated in a mouse model of vincristine-induced peripheral neuropathy...
January 23, 2024: Pharmaceuticals
https://read.qxmd.com/read/38387248/neurotoxicant-effects-of-bisphenol-a-nonylphenol-and-tert%C3%A2-butyl-phenol-in-the-nile-tilapia-oreochromis-niloticus
#19
JOURNAL ARTICLE
Armando Vega-López, Israel Lara-Vega, Genaro Atonal-Brioso, Minerva Nájera-Martínez
Worldwide production of alkyl phenols and ethoxylated alkyl phenols is high due to their broad industrial uses. It has been widely documented that they are endocrine disruptors, and it has been suggested that they could exert neurotoxic effects. However, a lack of information about the neurotoxic effects of APs and APEs prevails. In this study, the bisphenol A (BPA), 4-nonylphenol (NP), and 3‑tert-butylphenol (tertBP) effects on brain and spinal cord of Nile tilapia exposed to environmental concentrations were evaluated by assessing acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and carboxylesterases (CES) activities, and γ-aminobutyric acid (GABA) levels and their effects were evaluated by molecular docking...
February 20, 2024: Aquatic Toxicology
https://read.qxmd.com/read/38386999/reinfusion-of-cd19-car-t-cells-for-relapse-prevention-and-treatment-in-children-with-acute-lymphoblastic-leukemia
#20
JOURNAL ARTICLE
Regina M Myers, Kaitlin J Devine, Yimei Li, Sophie Lawrence, Allison Barz Leahy, Hongyan Liu, Lauren Vernau, Colleen Callahan, Diane Baniewicz, Stephan Kadauke, Regina McGuire, Gerald Wertheim, Irina Kulikovskaya, Vanessa Gonzalez, Joseph A Fraietta, Amanda DiNofia, Stephen P Hunger, Susan R Rheingold, Richard Aplenc, Carl H June, Stephan A Grupp, Lisa Wray, Shannon L Maude
Relapse after CD19-directed chimeric antigen receptor (CAR)-modified T-cells remains a substantial challenge. Short CAR T-cell persistence contributes to relapse risk, necessitating novel approaches to prolong durability. CAR T-cell reinfusion (CARTr) represents a potential strategy to reduce the risk of, or treat, relapsed disease after initial CAR infusion (CARTi). We conducted a retrospective review of reinfusion of murine (CTL019) or humanized (huCART19) anti-CD19.4-1BB CAR T-cells across 3 clinical trials or commercial tisagenlecleucel for relapse prevention [peripheral B-cell recovery (BCR) or bone marrow hematogones ≤6 months after CARTi], minimal residual disease (MRD) or relapse, or nonresponse to CARTi...
February 22, 2024: Blood Advances
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