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REVIEW
David Richer Araujo Coelho, Maia Gersten, Alma Sanchez Jimenez, Felipe Fregni, Paolo Cassano, Willians Fernando Vieira
INTRODUCTION: Neuropathic pain (NP) significantly impacts quality of life and often coexists with affective disorders such as anxiety and depression. Addressing both NP and its psychiatric manifestations requires a comprehensive understanding of therapeutic options. This study aimed to review the main pharmacological and non-pharmacological treatments for NP and comorbid affective disorders to describe their mechanisms of action and how they are commonly used in clinical practice. METHODS: A review was conducted across five electronic databases, focusing on pharmacological and non-pharmacological treatments for NP and its associated affective disorders...
April 4, 2024: Pain Practice: the Official Journal of World Institute of Pain
#2
JOURNAL ARTICLE
Wei Wang, Xixi Liu
BACKGROUND: Herpes Zoster Neuralgia (HZN) and Post-Herpetic Neuralgia (PHN) are neuropathic pain conditions following Varicella Zoster Virus infection. PHN primarily affects individuals aged 60 and above and the pervasive and severe neuropathic pain in PHN leads to significant emotional and psychological distress in approximately 80%-90% of patients, precipitating a decline in their overall quality of life and that of their families. Galectin-3, a pro-inflammatory factor, is implicated in inflammatory responses, potentially influencing neuronal damage and pain signal transmission...
February 9, 2024: Alternative Therapies in Health and Medicine
#3
JOURNAL ARTICLE
María Fernanda Pérez Hernández, Alejandra Calderón Vallejo, Sergio de Jesús Aguilar Castillo, Daniel Cuauhtémoc Gómez Jiménez, Eduardo Rodríguez Guerrero, Fátima Aguilar Morales, Macedonia Guadalupe Moreno Tovar, Miguel Alfredo Zurita Muñóz, Antonio Eduardo Bautista Cortéz, Claudia Camelia Calzada Mendoza, Mónica Ascención De Nova Ocampo, Juan Manuel Ordóñez Rodríguez, Mónica Luz Gómez Esquivel, Alberto García Méndez, Octavio Flores Gil, Víctor Manuel Macías Zaragoza, Gabriela Yanet Cortés Moreno, Citlaltepetl Salinas Lara, Germán Velázquez García, Héctor Iván Saldivar Cerón, Lucia Monserrat Pérez Navarro, Laura Ávila Jiménez, Jaime Héctor Gómez Zamudio, Margarita Díaz Flores, Miguel Cruz López, María Esther Ocharan Hernández, José de Jesús Peralta Romero
BACKGROUND: Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes mellitus (T2DM); its diagnosis and treatment are based on symptomatic improvement. However, as pharmacological therapy causes multiple adverse effects, the implementation of acupunctural techniques, such as electroacupuncture (EA) has been suggested as an alternative treatment. Nonetheless, there is a lack of scientific evidence, and its mechanisms are still unclear. We present the design and methodology of a new clinical randomized trial, that investigates the effectiveness of EA for the treatment of DPN...
February 15, 2024: BMC complementary medicine and therapies
#4
Paolo Piterà, Isabella Springhetti, Angelo Alito, Federica Verme, Jacopo Maria Fontana, Paolo Capodaglio
Phantom limb pain (PLP) is a challenging condition affecting a significant proportion of amputees. In this article, we describe the case of a 54-year-old Paralympic athlete with phantom limb syndrome following right leg amputation and widespread sports-related enthesitic pain who underwent a whole-body cryostimulation (WBC) cycle, an emerging treatment known for its rapid pain-relieving and anti-inflammatory effects. Assessments were conducted before and after a 10-session WBC cycle, including pain and quality of life assessment and use of medications...
December 22, 2023: Medicina
#5
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2021/8985721.].
2023: Evidence-based Complementary and Alternative Medicine: ECAM
#6
REVIEW
Praag Bhardwaj, Navdeep Ahuja, Ashwin Parchani, Shiana Singh, Dilasha Sethi, Monika Pathania
Yoga is an ancient wisdom comprising a multitude of physical and mental practices that are aimed toward a state of optimum physical, mental, social, and spiritual health. Neuropathic pain (NP) is caused by a lesion or disease of the somatosensory nervous system that is often unresponsive to currently available modes of treatment, portending an inferior quality of life for patients. This systematic review and meta-analysis aim to investigate the effect and the potential role of yoga in NP syndromes. PubMed, Scopus, Elton Bryson Stephens Company (EBSCO), and Cochrane Library were screened for randomized controlled trials (RCTs) assessing the effects of yoga in patients on NP...
October 2023: Journal of Family Medicine and Primary Care
#7
D Del Prete, G Ferrone, C Riso, A Piersanti, F Antonicelli, A Russo, A Modoni, M Rossi
BACKGROUND: Brachial plexus injury is a serious peripheral nerve injury that severely disables upper limbs and affects patients' daily life and work Acupuncture and Electroacupuncture have traditionally been used to treat neuropathic pain. However, there is still lacking evidence as regard to their effects on pain following traumatic nerve and plexus lesions. Neurotmesis after brachial plexus injury also causes movement disorders of the denervated muscles and loss of sensory function in the skin...
2023: La Clinica Terapeutica
#8
REVIEW
Anushka Dekhne, Harmin D Goklani, Neel Doshi, Rishabh Baskara Salian, Siddharth Kamal Gandhi, Priyansh Patel
Neuralgia is characterized by chronic pain resulting from damage or diseases in the somatosensory system, including nerves responsible for transmitting sensory information. Current treatments for neuropathic pain, which is a type of neuralgia, have limited success rates and can cause unwanted side effects. Since 1989, botulinum toxin-A (BTX-A), derived from the potent neurotoxin Clostridium botulinum , has been used to treat neuropathic pain in humans. BTX-A has shown analgesic effects by inhibiting the release of neurotransmitters involved in pain transmission...
October 2023: Curēus
#9
JOURNAL ARTICLE
Deciphering the Molecular Mechanism of Escin against Neuropathic Pain: A Network Pharmacology Study.
Xi Li, Yating Wu, Haoyan Wang, Zaiqi Li, Xian Ding, Chongyang Dou, Lin Hu, Guizhi Du, Guihua Wei
BACKGROUND: Escin is the main active component in Aesculus hippocastanum . It has been demonstrated that escin has anti-inflammatory properties. This study combined the methods of network pharmacology, molecular docking, and molecular dynamics to explore the molecular mechanism of escin against neuropathic pain (NP). METHODS: The Swiss Target Prediction and the Pharm Mapper database were employed for predicting the targets of escin. Also, the candidate targets of NP were gathered via the databases including Therapeutic Targets, DisGeNet, GeneCards, DrugBank, and OMIM...
2023: Evidence-based Complementary and Alternative Medicine: ECAM
#10
JOURNAL ARTICLE
Ichiro Okayasu, Mizuki Tachi, Erika Suzue, Nanae Ito, Yu Ozaki, Gaku Mishima, Shinji Kurata, Takao Ayuse
The patient was a 56-year-old woman who complained of chronic pain involving her tongue. We diagnosed her with burning mouth syndrome (BMS) based on exclusion of any local factors or systemic conditions. The patient not only had tongue pain but also had other signs and symptoms like scalloped tongue, dry mouth, and headache. To manage these additional issues, we used Goreisan, an herbal Kampo medicine, as a complementary alternative medicine (CAM) approach along with cognitive behavioral therapy (CBT). The patient's BMS was successfully managed with the combination of CAM and CBT, which may suggest that the pathophysiology for BMS might be nociplastic pain rather than purely nociceptive or neuropathic...
September 1, 2023: Anesthesia Progress
#11
REVIEW
M Huissoud, M Boussac, K Joineau, E Harroch, C Brefel-Courbon, E Descamps
Chronic pain is a non-motor symptom affecting from 60 to 80% of patients with Parkinson's disease (PD). PD patients can suffer from different types of pain, either specific or not specific of the disease, and depending on various pathophysiological mechanisms (nociceptive, nociplastic or neuropathic), which can be present at any stage of the disease. Non-pharmacological interventions (NPIs) are essential to complement routine care interventions in PD pain management. Moreover, in the literature, it has been shown that 42% of PD patients are already using complementary therapies...
October 11, 2023: Revue Neurologique
#12
REVIEW
Xintong Li, Yang Liu, Zheng Jing, Baozhu Fan, Weimin Pan, Shigang Mao, Yabing Han
OBJECTIVE: To evaluate the effectiveness of acupuncture in relieving diabetic neuropathic pain and to establish a more reliable and efficient foundation for acupuncture practice in diabetes care. METHODS: The Chinese National Knowledge Infrastructure, Wanfang database, Chongqing Weipu, Chinese Biomedical Literature Database, PubMed, Embase, and Cochrane Library were all searched for a randomized controlled trial research of acupuncture for DNP. Two researchers independently performed literature screening, quality evaluation, and data extraction...
November 2023: Complementary Therapies in Medicine
#13
JOURNAL ARTICLE
Sri-Arun Iamjan, Siriluk Veerasakul, Samur Thanoi, Waree Tiyaboonchai, Sutisa Nudmamud-Thanoi
OBJECTIVES: To investigate the effects of solid lipid microparticle (SLM) creams containing a long pepper extract (LPE) or piperine on neuropathy-related pain and the expression of Glial fibrillary acidic protein (GFAP) as a measure of astrogliosis. METHODS: Neuropathic pain in male Spraque Dawley rats was induced by sciatic nerve ligation (SNL) and followed by treatment with LPE-SLM, piperine-SLM, capsaicin or vehicle creams. The pain score was assessed by thermal hyperalgesia test...
September 18, 2023: Journal of Complementary & Integrative Medicine
#14
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2022/8547095.].
2023: Evidence-based Complementary and Alternative Medicine: ECAM
#15
JOURNAL ARTICLE
Amir Mahmoud Ahmadzade, Ghazaleh Pourali, Seyed Behzad Mirheidari, Matin Shirazinia, Mahdieh Hamedi, Ali Mehri, Hesam Amirbeik, Sajjad Saghebdoust, Zahra Tayarani-Najaran, Thozhukat Sathyapalan, Fatemeh Forouzanfar, Amirhossein Sahebkar
Neuropathic pain is a disabling condition caused by various diseases and can profoundly impact the quality of life. Unfortunately, current treatments often do not produce complete amelioration and can be associated with potential side effects. Recently, herbal drugs have garnered more attention as an alternative or a complementary treatment. In this article, we summarized the results of randomized clinical trials to evaluate the effects of various phytomedicines on neuropathic pain. In addition, we discussed their main bioactive components and potential mechanisms of action to provide a better view of the application of herbal drugs for treating neuropathic pain...
July 14, 2023: Current Pharmaceutical Biotechnology
#16
REVIEW
Brandon Goodwin, Maanas Chiplunkar, Ryan Salerno, Kylon Coombs, Umar Sannoh, Vrushank Shah, Nicholas Averell, Usmaan Al-Shebab, Deanna Janora
Aim: To investigate the potential benefit of topical capsaicin formulations. Materials & methods: A narrative systematic review was employed. Results: About 8% capsaicin patches were found to significantly reduce symptoms of diabetic peripheral neuropathy. Capsaicin was found to improve sleep quality (p = 0.02). Capsaicin patch exposure for 60 min showed significant reduction in symptoms (-32.8%). Capsaicin cream significantly reduced pain at weeks two and six (p = 0...
May 2023: Pain Management
#17
RANDOMIZED CONTROLLED TRIAL
Kristina Lagerstedt, Anna Efverman
OBJECTIVE: Since there is a lack of effective pharmacological therapies for chemotherapy-induced neuropathy and many patients ask for integrative cancer therapies such as acupuncture, the objective of this pilot study was to describe patients' experiences, and to study the feasibility and short-term effects of genuine acupuncture for chemotherapy-induced neuropathic pain and unpleasant sensations compared to sham acupuncture. METHODS: The pilot study used mixed methods, collecting quantitative and qualitative data...
2023: Integrative Cancer Therapies
#18
JOURNAL ARTICLE
Bin Xiao, Lishu Zhao, Yong Huang, Anqi Ma, Baoshun Pei, Zhengyu Li, Fei Gu
BACKGROUND: Clinical rehabilitation for brachial plexus injury is difficult in terms of chronic pain and dysfunction. Physiotherapy is considered a routine intervention for rehabilitation. Common physical therapy may require a variety of instruments. One approach that does not need instruments, but belongs to the field of complementary and alternative medicine, is naprapathy. Naprapathy, also called Tuina in China, has been applied in rehabilitation after brachial plexus injury for a long time...
May 29, 2023: JMIR Research Protocols
#19
REVIEW
Sanchita Dewanjee, Md Sohel, Md Shahadat Hossain, Farzana Ansari, Md Tofikul Islam, Farhana Sultana, Abdullah Al Mamun, Md Monirul Islam, Mohammad Nurul Amin
INTRODUCTION: People are treating their neuropathic pain with several approved and licensed pharmacological drugs. But due to having existing limitations like low efficacy with some side effects, there needs to be a more effective alternative and complementary therapeutic options. PURPOSE: s: The study was designed to discuss the mechanistic role of several clinically proven natural products that have been shown to play a significant role against different nerve pain or neuropathic pain...
May 2023: Heliyon
#20
REVIEW
Yuan Chang-Halabi, José Cordero, Xander Sarabia, Daniela Villalobos, Nelson P Barrera
Ionotropic receptors are ligand-gated ion channels triggering fast neurotransmitter responses. Among them, P2X and 5-HT3 receptors have been shown to physically interact each other and functionally inducing cross inhibitory responses. Nevertheless, despite the importance of P2X4 and 5-HT3A receptors that mediate for example neuropathic pain and psychosis respectively, complementary evidence has recently started to move forward in the understanding of this interaction. In this review, we discuss current evidence supporting the mechanism of crosstalking between both receptors, from the structural to the transduction pathway level...
May 6, 2023: Neuropharmacology
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