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Neuropathic pain complementary

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https://www.readbyqxmd.com/read/28275350/blockade-of-p2x4-receptors-inhibits-neuropathic-pain-related-behavior-by-preventing-mmp-9-activation-and-consequently-pronociceptive-interleukin-release-in-a-rat-model
#1
Agnieszka M Jurga, Anna Piotrowska, Wioletta Makuch, Barbara Przewlocka, Joanna Mika
Neuropathic pain is still an extremely important problem in today's medicine because opioids, which are commonly used to reduce pain, have limited efficacy in this type of pathology. Therefore, complementary therapy is needed. Our experiments were performed in rats to evaluate the contribution of the purinergic system, especially P2X4 receptor (P2X4R), in the modulation of glia activation and, consequently, the levels of nociceptive interleukins after chronic constriction injury (CCI) of the right sciatic nerve, a rat model of neuropathic pain...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28162257/-intramedullary-astrocytomas-a-french-retrospective-multicenter-study
#2
F Parker, C Campello, J-P Lejeune, P David, A Herbrecht, N Aghakhani, M Messerer
AIM: The authors report the results of a multicenter retrospective series with a long-term follow-up and the analysis of clinical, radiological, surgical data as well as the complementary treatments in patients with intramedullary astrocytomas (IA). MATERIALS AND METHODS: We performed a retrospective analysis of all the patients with IA operated on between 1984 and 2011 at 7 French centers (Kremlin-Bicêtre, Lille, Lyon, Marseille, Montpellier, Nice, and Nîmes)...
February 2, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28162253/-intramedullary-ependymomas-a-french-retrospective-multicenter-study-of-221%C3%A2-cases
#3
N Aghakhani, M Messerer, P David, A Herbrecht, F Parker
AIM: Intramedullary ependymomas (IE) are the most frequent intramedullary tumors in the adult population. The gold standard treatment is to obtain gross total removal without any new postoperative neurological deficit. The authors report the results of a multicenter series with a long-term follow-up and the analysis of clinical, radiological, surgical data as well as the complementary treatments. MATERIALS AND METHODS: A retrospective analysis of adult patients with IE operated on between January 1984 and December 2011 at 7 French centers (Bordeaux, Kremlin-Bicêtre, Lille, Lyon, Marseille, Montpellier, Nice, and Nîmes) was performed...
February 2, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28155755/changing-general-medical-practices-in-the-management-of-neuropathic-pain
#4
Mathieu Poucher, Claude Cherrier, Anne-Christelle Poucher, Paolo Di Patrizio
Objective: The objective of this study was to determine current practices in the Lorraine region in the treatment of neuropathic pain and to assess the challenges faced by general practitioners (GPs). Methods: We conducted a qualitative study by the focus group technique, by constituting a balanced panel of GPs to meet diversification requirements. The number of focus groups was defined to obtain data saturation. The lead author of this study acted as an observer, while a facilitator was responsible for moderating the debate...
October 19, 2016: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28112552/acupuncture-for-the-treatment-of-peripheral-neuropathy-a-systematic-review-and-meta-analysis
#5
Alexandra Dimitrova, Charles Murchison, Barry Oken
OBJECTIVES: Neuropathy and its associated pain pose great therapeutic challenges. While there has been a recent surge in acupuncture use and research, little remains known about its effects on nerve function. This review aims to assess the efficacy of acupuncture in the treatment of neuropathy of various etiologies. METHODS: The Medline, AMED, Cochrane, Scopus, CINAHL, and clintrials.gov databases were systematically searched from inception to July 2015. Randomized controlled trials (RCTs) assessing acupuncture's efficacy for poly- and mononeuropathy were reviewed...
March 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28090451/potential-of-pet-mri-for-imaging-of-non-oncologic-musculoskeletal-disease
#6
REVIEW
Feliks Kogan, Audrey P Fan, Garry E Gold
Early detection of musculoskeletal disease leads to improved therapies and patient outcomes, and would benefit greatly from imaging at the cellular and molecular level. As it becomes clear that assessment of multiple tissues and functional processes are often necessary to study the complex pathogenesis of musculoskeletal disorders, the role of multi-modality molecular imaging becomes increasingly important. New positron emission tomography-magnetic resonance imaging (PET-MRI) systems offer to combine high-resolution MRI with simultaneous molecular information from PET to study the multifaceted processes involved in numerous musculoskeletal disorders...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28054832/a-qualitative-exploration-of-living-with-chronic-neuropathic-pain-after-spinal-cord-injury-an-italian-perspective
#7
Valentina Buscemi, Elizabeth Cassidy, Cherry Kilbride, Frances Ann Reynolds
PURPOSE: The purpose of this study is to understand how people with spinal cord injury (SCI) in Italy experienced and managed chronic neuropathic pain (CNP), and their perspectives of Italian healthcare services. METHOD: Nine people with SCI participated. Two focus groups (three and four individuals) and one semi-structured interview were audio-recorded and transcribed. One "virtual interview" was conducted via e-mail. A qualitative thematic analysis was undertaken...
January 5, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27782944/chronic-sciatic-neuropathy-in-rat-reduces-voluntary-wheel-running-activity-with-concurrent-chronic-mechanical-allodynia
#8
Ryan A Whitehead, Nicholas L Lam, Melody S Sun, Joshua Sanchez, Shahani Noor, Arden G Vanderwall, Timothy R Petersen, Hugh B Martin, Erin D Milligan
BACKGROUND: Animal models of peripheral neuropathy produced by a number of manipulations are assessed for the presence of pathologic pain states such as allodynia. Although stimulus-induced behavioral assays are frequently used and important to examine allodynia (ie, sensitivity to light mechanical touch; von Frey fiber test), other measures of behavior that reflect overall function are not only complementary to stimulus-induced responsive measures, but are also critical to gain a complete understanding of the effects of the pain model on quality of life, a clinically relevant aspect of pain on general function...
January 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27243753/the-%C3%AE-7-nicotinic-receptor-dual-allosteric-agonist-and-positive-allosteric-modulator-gat107-reverses-nociception-in-mouse-models-of-inflammatory-and-neuropathic-pain
#9
Deniz Bagdas, Jenny L Wilkerson, Abhijit Kulkarni, Wisam Toma, Shakir AlSharari, Zulfiye Gul, Aron H Lichtman, Roger L Papke, Ganesh A Thakur, M Imad Damaj
BACKGROUND AND PURPOSE: Orthosteric agonists and positive allosteric modulators (PAMs) of the α7 nicotinic ACh receptor (nAChR) represent novel therapeutic approaches for pain modulation. Moreover, compounds with dual function as allosteric agonists and PAMs, known as ago-PAMs, add further regulation of receptor function. EXPERIMENTAL APPROACH: Initial studies examined the α7 ago-PAM, GAT107, in the formalin, complete Freund's adjuvant (CFA), LPS inflammatory pain models, the chronic constriction injury neuropathic pain model and the tail flick and hot plate acute thermal nociceptive assays...
August 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27008300/pudendal-neuralgia-due-to-pudendal-nerve-entrapment-warning-signs-observed-in-two-cases-and-review-of-the-literature
#10
Stephanie Ploteau, Claire Cardaillac, Marie-Aimee Perrouin-Verbe, Thibault Riant, Jean-Jacques Labat
Pudendal neuralgia is a chronic neuropathic pelvic pain that is often misdiagnosed and inappropriately treated. The Nantes criteria provide a basis for the diagnosis of pudendal neuralgia due to pudendal nerve entrapment. The 5 essential diagnostic criteria are pain situated in the anatomical territory of the pudendal nerve, worsened by sitting, the patient is not woken at night by the pain, and no objective sensory loss is detected on clinical examination. The fifth criterion is a positive pudendal nerve block...
March 2016: Pain Physician
https://www.readbyqxmd.com/read/26996621/rational-basis-for-the-use-of-bergamot-essential-oil-in-complementary-medicine-to-treat-chronic-pain
#11
REVIEW
L Rombolà, D Amantea, R Russo, A Adornetto, L Berliocchi, L Tridico, M T Corasaniti, S Sakurada, T Sakurada, G Bagetta, L A Morrone
In complementary medicine, aromatherapy uses essential oils to improve agitation and aggression observed in dementia, mood, depression, anxiety and chronic pain. Preclinical research studies have reported that the essential oil obtained from bergamot (BEO) fruit (Citrus bergamia, Risso) modifies normal and pathological synaptic plasticity implicated, for instance, in nociceptive and neuropathic pain. Interestingly, recent results indicated that BEO modulates sensitive perception of pain in different models of nociceptive, inflammatory and neuropathic pain modulating endogenous systems...
2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/26929531/burning-mouth-syndrome-current-concepts
#12
REVIEW
Cibele Nasri-Heir, Julyana Gomes Zagury, Davis Thomas, Sowmya Ananthan
Burning mouth syndrome (BMS) is a chronic pain condition. It has been described by the International Headache Society as "an intra-oral burning or dysesthetic sensation, recurring daily for more than 2 h/day for more than 3 months, without clinically evident causative lesions." BMS is frequently seen in women in the peri-menopausal and menopausal age group in an average female/male ratio of 7:1. The site most commonly affected is the anterior two-thirds of the tongue. The patient may also report taste alterations and oral dryness along with the burning...
October 2015: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/26870745/association-of-computerized-texture-features-on-mri-with-early-treatment-response-following-laser-ablation-for-neuropathic-cancer-pain-preliminary-findings
#13
Pallavi Tiwari, Shabbar F Danish, Benjamin Jiang, Anant Madabhushi
Laser interstitial thermal therapy (LITT) has recently emerged as a new treatment modality for cancer pain management that targets the cingulum (pain center in the brain) and has shown promise over radio frequency (RF)-based ablation, due to magnetic resonance image (MRI) guidance that allows for precise ablation. Since laser ablation for pain management is currently exploratory and is only performed at a few centers worldwide, its short- and long-term effects on the cingulum are currently unknown. Traditionally, treatment effects for neurological conditions are evaluated by monitoring changes in intensities and/or volume of the ablation zone on post-treatment Gadolinium-contrast T1-w (Gd-T1) MRI...
October 2015: Journal of Medical Imaging
https://www.readbyqxmd.com/read/26705410/simultaneous-quantification-of-unmyelinated-nerve-fibers-in-sural-nerve-and-in-skin
#14
Mathilde Duchesne, Laurent Magy, Laurence Richard, Pierre Ingrand, Jean-Philippe Neau, Stéphane Mathis, Jean-Michel Vallat
Peripheral polyneuropathies are common and their diagnosis may be challenging. We compared the results from sural-nerve and skin biopsies in 33 patients with a polyneuropathy and neuropathic pain examined in our hospital over a 6-year period. The biopsies were all from the same lower limb of each patient. Intraepidermal nerve fiber (IENF) densities in the skin were determined by fluorescence microscopy; unmyelinated fiber densities in sural-nerve biopsies (UFNB) were determined by electron microscopy. There was no correlation with age or gender in either biopsy type; there was a weak trend to correlation between UFNB density and IENF density, possibly because of the small sample size...
January 2016: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/26641136/a-pharmacological-treatment-algorithm-for-localized-neuropathic-pain
#15
Massimo Allegri, Ralf Baron, Guy Hans, Gerardo Correa-Illanes, Victor Mayoral Rojals, Gerard Mick, Michael Serpell
Neuropathic pain is caused by a lesion or disease affecting the somatosensory system and is difficult to manage, often proving refractory to existing treatments. In more than half of cases, it is localized and affects a specific, clearly circumscribed area of the body (localized neuropathic pain, or LNP). A recently developed screening tool enables patients with probable neuropathic pain/LNP to be identified quickly and easily. In view of the conflicting current treatment recommendations, an advisory board of pain specialists met in June 2015 to develop a complementary treatment guidance algorithm, for use in the primary care setting and by non-pain specialists...
2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/26614725/managing-neuropathic-pain
#16
REVIEW
Robert Carter Wellford Jones, Erin Lawson, Miroslav Backonja
Neuropathic pain (NP) arises from injuries or diseases affecting the somatosensory component of the nervous system at any level of the peripheral or central nervous system. NP is diagnosed based on common neurologic signs and symptoms. NP is best treated with a combination of multiple therapeutic approaches, and treatments include conservative, complementary, medical, interventional, and surgical treatment modalities. Goals of treatment are the same as in pain management and include improvement in pain control and in coping skills as well as restoration of functional status...
January 2016: Medical Clinics of North America
https://www.readbyqxmd.com/read/26608254/systemic-administration-of-resveratrol-suppress-the-nociceptive-neuronal-activity-of-spinal-trigeminal-nucleus-caudalis-in-rats
#17
Shiori Takehana, Kenta Sekiguchi, Maki Inoue, Yoshiko Kubota, Yukihiko Ito, Kei Yui, Yoshihito Shimazu, Mamoru Takeda
Although a modulatory role has been reported for the red wine polyphenol resveratrol on several types of ion channels and excitatory synaptic transmission in the nervous system, the acute effects of resveratrol in vivo, particularly on nociceptive transmission of the trigeminal system, remain to be determined. The aim of the present study was to investigate whether acute intravenous resveratrol administration to rats attenuates the excitability of wide dynamic range (WDR) spinal trigeminal nucleus caudalis (SpVc) neurons in response to nociceptive and non-nociceptive mechanical stimulation in vivo...
January 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/26522832/omeprazole-increases-the-efficacy-of-a-soluble-epoxide-hydrolase-inhibitor-in-a-pge%C3%A2-induced-pain-model
#18
Sumanta Kumar Goswami, Bora Inceoglu, Jun Yang, Debin Wan, Sean D Kodani, Carlos Antonio Trindade da Silva, Christophe Morisseau, Bruce D Hammock
Epoxyeicosatrienoic acids (EETs) are potent endogenous analgesic metabolites produced from arachidonic acid by cytochrome P450s (P450s). Metabolism of EETs by soluble epoxide hydrolase (sEH) reduces their activity, while their stabilization by sEH inhibition decreases both inflammatory and neuropathic pain. Here, we tested the complementary hypothesis that increasing the level of EETs through induction of P450s by omeprazole (OME), can influence pain related signaling by itself, and potentiate the anti-hyperalgesic effect of sEH inhibitor...
December 15, 2015: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/26485261/targeting-neuropathic-pain-consider-these-alternatives
#19
REVIEW
Mary Onysko, Presley Legerski, Jessica Potthoff, Michael Erlandson
When patients with painful peripheral neuropathy fail to respond to--or are unable to tolerate--standard therapies, consider these lesser-known treatments.
August 2015: Journal of Family Practice
https://www.readbyqxmd.com/read/26335279/the-cupcig-cam-use-in-primary-care-in-germany-study-part-i-pain-study-protocol-of-a-pilot-trial-to-assess-feasibility-acceptability-and-perceived-effectiveness-of-cam-in-pain-disorders-in-primary-care
#20
Martin Schencking, Andreas Sönnichsen, Susanne Bassüner, Marcus Redaelli
BACKGROUND: There is limited valid data available on CAM procedures for chronic joint and neuropathic pain in primary care in Germany. Indiviual CAM qualifications of the general practitioners (GPs) and the potential of cost reduction through CAM treatment are almost unknown. The aim of this pilot trial preceding the main study is to examine the survey mode, to estimate the response rate by GPs with or without an additional qualification for CAM, and to identify the status quo in therapeutic approaches for chronic pain disorders in primary care...
2015: Forschende Komplementärmedizin, Research in Complementary Medicine
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