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https://www.readbyqxmd.com/read/28930945/effects-of-propranolol-and-clonidine-on-brain-edema-blood-brain-barrier-permeability-and-endothelial-glycocalyx-disruption-following-fluid-percussion-brain-injury-in-the-rat
#1
Gustav Folmer Genét, Peter Bentzer, Morten Bagge Hansen, Sisse Rye Ostrowski, Pär Ingemar Johansson
BACKGROUND: Traumatic brain injury causes a disruption of the vascular endothelial glycocalyx layer that is associated with an overactivation of the sympathoadrenal system. We hypothesized that early and unselective beta-blockade with propranolol alone or in combination with the alfa2-agonist clonidine would decrease brain edema, blood-brain-barrier permeability and glycocalyx disruption at 24 hours after trauma. METHODS: We subjected fifty-three adult male Sprague-Dawley rats to lateral fluid-percussion brain injury and randomized infusion with propranolol (n=16), propranolol+clonidine (n=16), vehicle (n=16) or sham (n=5) for 24 hours...
September 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28929453/effects-of-long-term-ingestion-of-white-tea-on-oxidation-produced-by-aging-and-acute-oxidative-damage-in-rats
#2
Cristóbal Espinosa Ruiz, Lorena Cabrera, José Ángel López-Jiménez, Salvador Zamora, Francisca Pérez-Llamas
The infusion tea extracted from the leaves of the plant Camellia sinensis can be used in the prevention of cancer, cardiovascular and neurodegenerative diseases, and aging, while adriamycin (ADR) is an anticancer drug that increases oxidative stress in cells. The present study evaluated the protective effect of the long-term consumption of white tea used at two different doses against the oxidative stress produced by aging and acute oxidation caused ADR treatment. At wearing, rats received distilled water (control), or 0...
September 19, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28924484/diabetic-ketoacidosis-producing-extreme-hyperkalemia-in-a-patient-with-type-1-diabetes-on-hemodialysis
#3
Hodaka Yamada, Shunsuke Funazaki, Masafumi Kakei, Kazuo Hara, San-E Ishikawa
Diabetic ketoacidosis (DKA) is a critical complication of type 1 diabetes associated with water and electrolyte disorders. Here, we report a case of DKA with extreme hyperkalemia (9.0 mEq/L) in a patient with type 1 diabetes on hemodialysis. He had a left frontal cerebral infarction resulting in inability to manage his continuous subcutaneous insulin infusion pump. Electrocardiography showed typical changes of hyperkalemia, including absent P waves, prolonged QRS interval and tented T waves. There was no evidence of total body water deficit...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28912711/increased-hippocampal-probdnf-contributes-to-memory-impairments-in-aged-mice
#4
Mona Buhusi, Chris Etheredge, Ann-Charlotte Granholm, Catalin V Buhusi
Memory decline during aging or accompanying neurodegenerative diseases, represents a major health problem. Neurotrophins have long been considered relevant to the mechanisms of aging-associated cognitive decline and neurodegeneration. Mature Brain-Derived Neurotrophic Factor (BDNF) and its precursor (proBDNF) can both be secreted in response to neuronal activity and exert opposing effects on neuronal physiology and plasticity. In this study, biochemical analyses revealed that increased levels of proBDNF are present in the aged mouse hippocampus relative to young and that the level of hippocampal proBDNF inversely correlates with the ability to perform in a spatial memory task, the water radial arm maze (WRAM)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28904323/effects-of-bittern-water-on-cariogenic-bacteria-and-saliva-secretion
#5
Mariko Ohtsu, Muneaki Tamura, Hideto Sasaki, Shuichi Sato, Masatake Asano
The effects of bittern water (BW), obtained from the ocean floor, on cariogenic bacteria and saliva secretion were examined. Streptococcus mutans was mixed with BW for 1, 3, 5, 10, and 20 min to explore the bactericidal effects of BW against cariogenic bacteria. Bacterial viability was calculated by counting the number of colony-forming units on Brain Heart Infusion agar plates. The results indicated a bacterial viability of more than 35% even after 20 min of incubation. Subsequently, the effects of BW on saliva secretion and the salivary concentration of secretory IgA (sIgA) were examined...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28895389/study-of-nutritional-value-of-dried-tea-leaves-and-infusions-of-black-green-and-white-teas-from-chinese-plantations
#6
Maria Czernicka, Grzegorz Zaguła, Marcin Bajcar, Bogdan Saletnik, Czesław Puchalski
Background: The processing of tea leaves determines the contents of bioactive ingredients, hence it should be expected that each variety of tea, black, red or green, will represent a different package of compounds of physiological importance. Taste and aroma, as well as price and brand are the main factors impacting consumers’ preferences with regard to tea of their choice; on the other hand consumers less frequently pay attention to the chemical composition and nutritional value of tea...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28895237/a-comprehensive-characterisation-of-rosemary-tea-obtained-from-rosmarinus-officinalis-l-collected-in-a-sub-humid-area-of-tunisia
#7
Mariem Achour, Raquel Mateos, Maha Ben Fredj, Ali Mtiraoui, Laura Bravo, Saad Saguem
INTRODUCTION: Rosemary (Rosmarinus officinalis L.) is an aromatic plant common in Tunisia and it is widely consumed as a tea in traditional cuisine and in folk medicine to treat various illnesses. Currently, most research efforts have been focused on rosemary essential oil, alcoholic and aqueous extracts, however, little is reported on rosemary infusion composition. OBJECTIVE: To investigate compounds present in rosemary tea obtained from Rosmarinus officinalis L...
September 12, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28894626/ultraviolet-light-assisted-extraction-of-flavonoids-and-allantoin-from-aqueous-and-alcoholic-extracts-of-symphytum-officinale
#8
Marwan S M Al-Nimer, Zainab Wahbee
AIM: Symphytum officinale (comfrey) is a medicinal plant commonly used in decoction and to treat ailments. It protects the skin against ultraviolet (UV)-irradiation. UV irradiation may induce variable effects on the constituents of herbal extracts and thereby may limit or improve the advantages of using these extracts as medicinal supplements. This study aimed to assess the effect of UV radiations including UV-A, UV-B, and UV-C on the constituents of S. officinale aqueous and alcoholic extracts...
July 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28886249/chronic-5-ht-sub-2-sub-receptor-blockade-unmasks-the-role-of-5-ht-sub-1f-sub-receptors-in-the-inhibition-of-the-rat-cardioaccelerator-sympathetic-outflow
#9
José Ángel García-Pedraza, Oswaldo Hernández-Abreu, Mónica García, Asunción Morán, Carlos M Villalón
Serotonin (5-hydroxytryptamine; 5-HT) inhibits the rat cardioaccelerator sympathetic outflow by 5-HT<sub>1B/1D/5</sub> receptors. Since chronic blockade of sympatho-excitatory 5-HT<sub>2</sub> receptors is beneficial in several cardiovascular pathologies, this study investigated whether sarpogrelate (a 5-HT<sub>2</sub> receptor antagonist) alters the pharmacological profile of the above sympatho-inhibition. Rats were pretreated during 2 weeks with sarpogrelate in drinking water (30 mg/kg...
September 8, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28881312/lc-ms-ms-assay-for-the-quantitation-of-the-ribonucleotide-reductase-inhibitor-triapine-in-human-plasma
#10
Julia Matsumoto, Brian F Kiesel, Robert A Parise, Jianxia Guo, Sarah Taylor, Marilyn Huang, Julie L Eiseman, S Percy Ivy, Charles Kunos, Edward Chu, Jan H Beumer
The ribonucleotide reductase inhibitor and radiosensitizer triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP), NSC 663249) is clinically being evaluated via the intravenous (IV) route for the treatment of cervical and vulvar cancer in combination with primary cisplatin chemoradiation. The need for a 2-h infusion and frequent administration of triapine is logistically challenging, prompting us to pursue oral (PO) administration. In support of the clinical trial investigating oral triapine in combination with chemoradiation, we developed and validated a novel LC-MS/MS assay for the quantification of triapine in 50μL human plasma...
August 31, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28877076/disruption-of-the-with-no-lysine-kinase-ste20-proline-alanine-rich-kinase-pathway-reduces-the-hypertension-induced-by-angiotensin-ii
#11
Luz G Cervantes-Perez, Maria Castaneda-Bueno, Jose V Jimenez, Norma Vazquez, Lorena Rojas-Vega, Dario R Alessi, Norma A Bobadilla, Gerardo Gamba
OBJECTIVE: The hypertensive effect of angiotensin II (AngII), a peptide hormone, is dependent on its intrarenal actions and the activation of the renal Na-Cl cotransporter (NCC), by AngII requires integrity of the with no lysine kinase/STE20-proline alanine-rich kinase (WNK/SPAK) signaling pathway. Here, we analyzed if the integrity of the WNK/SPAK pathway is required for AngII infusion to induce arterial hypertension. METHODS: We tested the effect of AngII or aldosterone administration on the blood pressure and on pNCC/NCC ratio in SPAK knock-in mice in which the kinase and thus NCC cannot be activated by WNK kinases...
September 14, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28873637/rapid-analysis-of-fungicides-in-tea-infusions-using-ionic-liquid-immobilized-fabric-phase-sorptive-extraction-with-the-assistance-of-surfactant-fungicides-analysis-using-il-fpse-assisted-with-surfactant
#12
Miyi Yang, Yihan Gu, Xiaoling Wu, Xuefei Xi, Xiaoling Yang, Wenfeng Zhou, Haozhe Zeng, Sanbing Zhang, Runhua Lu, Haixiang Gao, Jing Li
A green, simple, inexpensive, and sensitive ionic liquid immobilized fabric phase sorptive extraction method coupled with high performance liquid chromatography was developed for rapid screening and simultaneous determination of four fungicides (azoxystrobin, chlorothalonil, cyprodinil and trifloxystrobin) residues in tea infusions. This IL modified extraction fiber is capable of extracting target analytes directly from complicated tea water matrices with the addition of surfactant. A series of extraction conditions were investigated by one-factor-at-a-time approach and orthogonal test...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28868535/configurable-microfluidic-platform-for-investigating-therapeutic-delivery-from-biomedical-device-coatings
#13
Zidong Li, Erkin Seker
Advanced biomedical device coatings have shown significant promise in delivery of therapeutics (e.g., small-molecule drugs, proteins) for a wide range of medical interventions ranging from targeted cancer therapy to management of atherosclerosis. In order to accelerate the development of such coatings, there is a need for tools to investigate the loading capacity and release kinetics with high temporal resolution and in a variety of physiological conditions. To address this need, we report a microfluidic platform, where the coating on a substrate can be mounted onto the microchannel and the device can be configured in two physiologically-relevant modes: (i) flow-mode allows for monitoring the release from the coating in contact with a liquid flowing at a specific rate, modeling the case of a drug-eluting stent...
September 4, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28865383/fluoride-concentrations-in-traditional-and-herbal-teas-health-risk-assessment
#14
Suchismita Das, Letuzia M de Oliveira, Evandro da Silva, Yungen Liu, Lena Q Ma
Traditional tea (Camellia sinensis) and herbal tea are being consumed across the world. However, long term consumption of tea can increase the chances of fluorosis owing to the presence of fluoride (F) in teas. Therefore, it is imperative to assess the health risk associated with tea consumption. The main objectives of this study were to: 1) estimate total F in 47 popular teas, including traditional and herbal teas and F concentrations in 1% (w/v) infusion of 5 min, and 2) assess the exposure risks of F from tea consumption in children and adults...
August 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28861607/glomerular-and-tubular-effects-of-nitric-oxide-no-are-regulated-by-angiotensin-ii-ang-ii-in-an-age-dependent-manner-through-activation-of-both-angiotensin-receptors-at1rs-and-at2rs-in-conscious-lambs
#15
Angela E Vinturache, Francine G Smith
Renin-angiotensin (RAS) and nitric oxide (NO) systems and the balance and interaction between them are considered of primary importance in maintaining fluid and electrolyte homeostasis. It has been suggested that the effects of NO may be modulated at least in part by the angiotensin (Ang) II, yet the roles of angiotensin receptor type 1 (AT1R) and type 2 (AT2R) are not well understood. Even though both Ang II and NO are elevated at birth and during the newborn period, their contribution to the adaptation of the newborn to life after birth as well as their physiological roles during development are poorly understood...
August 31, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28860992/rewarding-effects-of-operant-dry-licking-behavior-on-neuronal-firing-in-the-nucleus-accumbens-core
#16
Enrico Patrono, Jumpei Matsumoto, Hiroshi Nishimaru, Yusaku Takamura, Ikhruud C Chinzorig, Taketoshi Ono, Hisao Nishijo
Certain eating behaviors are characterized by a trend of elevated food consumption. However, neural mechanisms mediating the motivation for food consumption are not fully understood. Food impacts the brain-rewarding-system via both oral-sensory and post-ingestive information. Recent studies have reported an important role of visceral gut information in mediating dopamine (DA) release in the brain rewarding system. This is independent of oral sensation, suggesting a role of the gut-brain-DA-axis in feeding behavior...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28860165/influence-of-nutrient-ingestion-on-amino-acid-transporters-and-protein-synthesis-in-human-skeletal-muscle-after-sprint-exercise
#17
Håkan Claes Rundqvist, Mona Esbjörnsson, Olav Rooyackers, Ted Osterlund, Marcus Moberg, William Apró, Eva Blomstrand, Eva Jansson
Nutrient ingestion is known to increase the exercise-induced stimulation of muscle protein synthesis following resistance exercise. Less is known about the effect of nutrients on muscle protein synthesis following sprint exercise. At two occasions separated by one month, twelve healthy subjects performed three 30-s sprints with 20-min rest between bouts. In randomized order, they consumed a drink with essential amino acids and maltodextrin (nutrient) or flavored water (placebo). Muscle biopsies were obtained 80 and 200 min after the last sprint and blood samples were taken repeatedly during the experiment...
August 31, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28857895/cecal-intubation-time-between-cap-assisted-water-exchange-and-water-exchange-colonoscopy-a-randomized-controlled-trial
#18
Chih-Wei Tseng, Malcolm Koo, Yu-Hsi Hsieh
BACKGROUND AND AIM: The water exchange (WE) method can decrease the discomfort of the patients undergoing colonoscopy. It also provides salvage cleansing and improves adenoma detection, but a longer intubation time is required. Cap-assisted colonoscopy leads to a significant reduction in cecal intubation time compared with traditional colonoscopy with air insufflation. The aim of this study was to investigate whether combined cap-assisted colonoscopy and water exchange (CWE) could decrease the cecal intubation time compared with WE...
August 29, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28856625/inhibition-of-p2x7-receptor-ameliorates-nuclear-factor-kappa-b-mediated-neuroinflammation-induced-by-status-epilepticus-in-rat-hippocampus
#19
Cheng Huang, Xiao-Sa Chi, Rui Li, Xin Hu, Hai-Xia Xu, Jin-Mei Li, Dong Zhou
P2X7 receptor (P2X7R) has been reported participating in neuroinflammation in multiple neurological diseases. We explored the role of P2X7R in a rat status epilepticus (SE) model induced by coriaria lactone (CL) and its association with neuroinflammation. Thirty minutes after intracerebroventricular infusion with P2X7R antagonists Brilliant blue G (BBG), A-438079, A-740003, or agonists 2',3'-O-(4-benzoylbenzoyl)-adenosine 5'-triphosphate (BzATP), SE was induced by intramuscular injection of CL in Sprague-Dawley rats...
August 30, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28836787/self-healing-superhydrophobic-materials-showing-quick-damage-recovery-and-long-term-durability
#20
Liming Wang, Chihiro Urata, Tomoya Sato, Matt W England, Atsushi Hozumi
Superhydrophobic coatings/materials are important for a wide variety of applications, but the majority of these man-made coatings/materials still suffer from poor durability because of their lack of self-healing ability. Here, we report novel superhydrophobic materials which can quickly self-heal from various severe types of damage. In this study, we used poly(dimethylsiloxane) (PDMS) infused with two liquids: trichloropropylsilane, which reacts with ambient moisture to self-assemble into grass-like microfibers (named silicone micro/nanograss) on the surfaces and low-viscosity silicone oil (SO), which remains within the PDMS matrices and acts as a self-healing agent...
September 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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