Marjolein Garsen, Baranca Buijsers, Marloes Sol, Lena Gockeln, Ramon Sonneveld, Toin H van Kuppevelt, Mark de Graaf, Jacob van den Born, Jan A A M Kamps, Daniël H van Raalte, Rutger W van der Meer, Hildo J Lamb, Jan-Luuk Hillebrands, Ton J Rabelink, Marissa L Maciej-Hulme, Guido Krenning, Tom Nijenhuis, Johan van der Vlag
BACKGROUND: Proteinuria is associated with many glomerular diseases and a risk factor for the progression to renal failure. We previously showed that heparanase (HPSE) is essential for the development of proteinuria, whereas peroxisome proliferator-activated receptor ɣ (PPARɣ) agonists can ameliorate proteinuria. Since a recent study showed that PPARɣ regulates HPSE expression in liver cancer cells, we hypothesized that PPARɣ agonists exert their reno-protective effect by inhibiting glomerular HPSE expression...
March 6, 2023: EBioMedicine