keyword
https://read.qxmd.com/read/38485342/jtt-654-an-11-beta-hydroxysteroid-dehydrogenase-type-1-inhibitor-improves-hypertension-and-diabetic-kidney-injury-by-suppressing-angiotensinogen-production
#1
JOURNAL ARTICLE
Shiro Heitaku, Tomohiko Sasase, Tomohiro Sotani, Mimi Maki, Takashi Kawai, Hisayo Morinaga, Jun Nishiu
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays an important role in regulating the expression of glucocorticoid actions in target tissues. Overexpression of 11β-HSD1 in mouse adipose tissue causes a metabolic syndrome-like phenotype, leading to hypertension. Although, many 11β-HSD1 inhibitors have been studied, few have shown a clear ameliorative effect against hypertension. We investigated whether JTT-654, a novel 11β-HSD1 inhibitor, ameliorated hypertension and elucidated the underlying mechanisms...
April 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38460271/novel-thiazolidin-4-one-benzenesulfonamide-hybrids-as-ppar%C3%AE-agonists-design-synthesis-and-in-vivo-anti-diabetic-evaluation
#2
JOURNAL ARTICLE
Islam H Ali, Rasha M Hassan, Ahmed M El Kerdawy, Mahmoud T Abo-Elfadl, Heba M I Abdallah, Francesca Sciandra, Iman A Y Ghannam
In the current study, two series of novel thiazolidin-4-one benzenesulfonamide arylidene hybrids 9a-l and 10a-f were designed, synthesized and tested in vitro for their PPARɣ agonistic activity. The phenethyl thiazolidin-4-one sulphonamide 9l showed the highest PPARɣ activation % by 41.7%. Whereas, the 3-methoxy- and 4-methyl-4-benzyloxy thiazolidin-4-one sulphonamides 9i, and 9k revealed moderate PPARɣ activation % of 31.7, and 32.8%, respectively, in addition, the 3-methoxy-3-benzyloxy thiazolidin-4-one sulphonamide 10d showed PPARɣ activation % of 33...
February 29, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38328413/long-term-benefits-of-dapagliflozin-on-renal-outcomes-of-type-2-diabetes-under-routine-care-a-comparative-effectiveness-study-on-propensity-score-matched-cohorts-at-low-renal-risk
#3
JOURNAL ARTICLE
Gian Paolo Fadini, Enrico Longato, Mario Luca Morieri, Stefano Del Prato, Angelo Avogaro, Anna Solini
BACKGROUND: Despite the overall improvement in care, people with type 2 diabetes (T2D) experience an excess risk of end-stage kidney disease. We evaluated the long-term effectiveness of dapagliflozin on kidney function and albuminuria in patients with T2D. METHODS: We included patients with T2D who initiated dapagliflozin or comparators from 2015 to 2020. Propensity score matching (PSM) was performed to balance the two groups. The primary endpoint was the change in estimated glomerular filtration rate (eGFR) from baseline to the end of observation...
March 2024: The Lancet regional health. Europe
https://read.qxmd.com/read/38137521/the-safety-and-efficacy-of-combining-saxagliptin-and-pioglitazone-therapy-in-streptozocin-induced-diabetic-rats
#4
JOURNAL ARTICLE
Ahmed Mohamed Othman, Ibrahim Ashour Ibrahim, Samy M Saleh, Dina M Abo-Elmatty, Noha M Mesbah, Asmaa R Abdel-Hamed
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic progressive disease due to insulin resistance. Oxidative stress complicates the etiology of T2DM. Saxagliptin is a selective dipeptidyl peptidase-4 (DPP-4) inhibitor, while Pioglitazone is a thiazolidinedione insulin sensitizer. This study aimed to assess the effect of Saxagliptin and Pioglitazone monotherapy and combination therapy on the biochemical and biological parameters in streptozotocin (STZ)-induced diabetic rats. METHODS: The study included thirty-five male albino rats...
December 13, 2023: Biomedicines
https://read.qxmd.com/read/38128823/canagliflozin-improves-fatty-acid-oxidation-and-ferroptosis-of-renal-tubular-epithelial-cells-via-foxa1-cpt1a-axis-in-diabetic-kidney-disease
#5
JOURNAL ARTICLE
Tian Gan, Qingzhu Wang, Yi Song, Mingwei Shao, Yanyan Zhao, Feng Guo, Fangyi Wei, Xunjie Fan, Wei Zhang, Yuanyuan Luo, Duo Chen, Shanshan Wang, Guijun Qin
Impaired fatty acid oxidation (FAO) is a metabolic hallmark of renal tubular epithelial cells (RTECs) under diabetic conditions. Disturbed FAO may promote cellular oxidative stress and insufficient energy production, leading to ferroptosis subsequently. Canagliflozin, an effective anti-hyperglycemic drug, may exert potential reno-protective effects by upregulating FAO and inhibiting ferroptosis in RTECs. However, the mechanisms involved remain unclear. The present study is aimed to characterize the detailed mechanisms underlying the impact of canagliflozin on FAO and ferroptosis...
December 19, 2023: Molecular and Cellular Endocrinology
https://read.qxmd.com/read/38024775/renoprotective-potency-of-sitagliptin-versus-pioglitazone-in-type-2-diabetic-patients-impact-on-lncmiat
#6
JOURNAL ARTICLE
Mohamed A Kandeil, Mohamed A Shaarawy, Hamdy A Mourad, Mohamed O Mahmoud
Background: Diabetes mellitus (DM) represents one of the most important reasons for chronic kidney diseases due to the high level of blood glucose that destructs blood vessels. Objective: The present study focused on investigating the protective impact of sitagliptin on kidney complication in type 2 diabetes mellitus (T2DM) patients in comparison to pioglitazone to examine which has the superior effect against the nephritic complication of DM. Methods: Eighty adult subjects were classified into four groups: control group, pioglitazone-treated T2DM patients (P group), sitagliptin-treated T2DM patients for less than one year (SL group), and sitagliptin-treated T2DM patients for more than one year (SM group)...
November 14, 2023: ACS Omega
https://read.qxmd.com/read/37958504/pioglitazone-protects-tubular-epithelial-cells-during-kidney-fibrosis-by-attenuating-mirna-dysregulation-and-autophagy-dysfunction-induced-by-tgf-%C3%AE
#7
JOURNAL ARTICLE
Anna Manzéger, Gantsetseg Garmaa, Miklós M Mózes, Georg Hansmann, Gábor Kökény
Excessive renal TGF-β production and pro-fibrotic miRNAs are important drivers of kidney fibrosis that lack any efficient treatment. Dysfunctional autophagy might play an important role in the pathogenesis. We aimed to study the yet unknown effects of peroxisome proliferator-activated receptor-γ (PPARγ) agonist pioglitazone (Pio) on renal autophagy and miRNA dysregulation during fibrosis. Mouse primary tubular epithelial cells (PTEC) were isolated, pre-treated with 5 µM pioglitazone, and then stimulated with 10 ng/mL TGF-β1 for 24 h...
October 24, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37762244/postprandial-hyperlipidemia-its-pathophysiology-diagnosis-atherogenesis-and-treatments
#8
REVIEW
Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama
Postprandial hyperlipidemia showing postprandial increases in serum triglyceride (TG) is associated with the development of atherosclerotic cardiovascular disease (ASCVD). To diagnose postprandial hyperlipidemia, the oral fat loading test (OFLT) should be performed; however, this test is very time-consuming and is difficult to perform. Elevated serum TG levels reflect an increase in TG-rich lipoproteins (TRLs), such as chylomicrons (CM), very low-density lipoproteins (VLDL), and their remnants (CM remnants [CMRs] and VLDL remnants [VLDLRs])...
September 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37749346/modulation-of-ppar-%C3%AE-srebp-1c-and-inflammatory-mediators-by-luteolin-ameliorates-%C3%AE-cell-dysfunction-and-renal-damage-in-a-rat-model-of-type-2-diabetes-mellitus
#9
JOURNAL ARTICLE
Syed Ilyas Shehnaz, Anitha Roy, Rajagopalan Vijayaraghavan, Senthilkumar Sivanesan, Natesan Pazhanivel
BACKGROUND: Natural products have been recommended as a complementary therapy for type 2 diabetes mellitus (T2DM) due to constraints of safety and tolerability of existing anti-diabetic agents. Luteolin exhibits anti-diabetic and anti-inflammatory effects. Hence, the impact of luteolin on glucose homoeostasis and organ damage was investigated in high-fat diet (HFD) and streptozotocin (STZ) induced T2DM in rats. METHODS AND RESULTS: Male Wistar rats were maintained on HFD (provided 55% energy as fat) for 10 days...
September 26, 2023: Molecular Biology Reports
https://read.qxmd.com/read/37554909/dlbs3233-enhances-nephrin-and-podocin-expression-also-reduces-oxidative-stress-marker-and-insulin-receptor-serine-diabetic-rats-podocytes
#10
JOURNAL ARTICLE
Chandra I Mohani, Achmad Rudijanto, Aulanni'am Aulanni'am, Setyawati Soeharto
UNLABELLED: Numerous oxidative stresses are detected in patients with diabetic kidney disease, resulting in insulin resistance that damages the pancreas and kidney. Renal podocytes insensitive to insulin lead to decreased nephrin and podocin and increased insulin receptor serine. The authors did an experiment on diabetic rats to examine the effect of DLBS3233 on repairing insulin resistance. MATERIALS AND METHODS: Thirty adult male Wistar rats were randomly divided into six groups ( n =5 per group): group of nondiabetic rats as a negative control (group 1); untreated diabetic rats (group 2); diabetic rats treated with DLBS3233 4...
August 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/37493956/pioglitazone-a-ppar-y-agonist-as-one-of-the-new-therapeutic-candidates-for-c3-glomerulopathy
#11
JOURNAL ARTICLE
Elia Balestra, Egidio Barbi, Viola Ceconi, Vittorio Di Maso, Ester Conversano, Marco Pennesi
BACKGROUND: C3-glomerulopathy (C3G) is a rare pediatric kidney disease characterised by dysregulation of the alternative complement pathway, with glomerular deposition of C3. C3G may often present as a steroid-resistant nephrotic syndrome (SRNS), and there is no established effective therapy: the usual treatment involves corticosteroids and immunosuppressive drugs. Pioglitazone, a PPAR-γ agonist with a protective action on podocytes, was reported in a few cases as helpful in reducing proteinuria when combined with steroids...
July 26, 2023: Pediatric Nephrology
https://read.qxmd.com/read/37180728/preeclamptic-programming-unevenly-perturbs-inflammatory-and-renal-vasodilatory-outcomes-of-endotoxemia-in-rat-offspring-modulation-by-losartan-and-pioglitazone
#12
JOURNAL ARTICLE
Hagar A Morgaan, Marwa Y Sallam, Hanan M El-Gowelli, Sahar M El-Gowilly, Mahmoud M El-Mas
Introduction: Preeclampsia (PE) enhances the vulnerability of adult offspring to serious illnesses. The current study investigated whether preeclamptic fetal programming impacts hemodynamic and renal vasodilatory disturbances in endotoxic adult offspring and whether these interactions are influenced by antenatal therapy with pioglitazone and/or losartan. Methods: PE was induced by oral administration of L-NAME (50 mg/kg/day) for the last 7 days of pregnancy. Adult offspring was treated with lipopolysaccharides (LPS, 5 mg/kg) followed 4-h later by hemodynamic and renovascular studies...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37156296/the-protective-role-of-peroxisome-proliferator-activated-receptor-gamma-in-lipotoxic-podocytes
#13
JOURNAL ARTICLE
Almudena G Carrasco, Adriana Izquierdo-Lahuerta, Ángela M Valverde, Lan Ni, Elena Flores-Salguero, Richard J Coward, Gema Medina-Gómez
Podocytes are specialized epithelial cells that maintain the glomerular filtration barrier. These cells are susceptible to lipotoxicity in the obese state and irreversibly lost during kidney disease leading to proteinuria and renal injury. PPARγ is a nuclear receptor whose activation can be renoprotective. This study examined the role of PPARγ in the lipotoxic podocyte using a PPARγ knockout (PPARγKO) cell line and since the activation of PPARγ by Thiazolidinediones (TZD) is limited by their side effects, it explored other alternative therapies to prevent podocyte lipotoxic damage...
July 2023: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
https://read.qxmd.com/read/37029756/novel-hits-for-autosomal-dominated-polycystic-kidney-disease-adpkd-targeting-derived-by-in-silico-screening-on-zinc-15-natural-product-database
#14
JOURNAL ARTICLE
Mojgan Nejabat, Farzin Hadizadeh, Masoud Nejabat, Omid Rajabi
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disorder that leads to growth cysts in the kidney, ultimately resulting in loss of function. Currently, no effective drug therapy can be safely used in the clinic. So, looking for effective therapeutic drugs is urgent for treating ADPKD. Our natural product library was prepared based on the ZINC-15 database. Lipinski's rule of five, drug-likeness, and toxicity screening of the designed library were evaluated. Swiss model online server was used for modeling of GANAB target...
April 8, 2023: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/36988379/impact-of-peroxisome-proliferator-activated-receptor-agonist-drugs-in-a-model-of-nephrotoxicity-in-rats
#15
JOURNAL ARTICLE
Azza A Ali, Eman B Saad, Rana H Abd El-Rhman, Ola M Abd El-Raouf, Amany M Gad
Doxorubicin (DOX) is one of the basic anticancer drugs, nonetheless its use is restricted due to noxious side effects. Kidney failure is one of the main side effects that restrict its medical use. The current study assessed the nephroprotective effects of fenofibrate and pioglitazone against the renal injury induced by doxorubicin in rats and illustrated the probable mechanisms underlying these protective effects. For this purpose, Male Sprague-Dawley rats weighing (200-230 g) were allocated into seven groups treated for 15 days as following: control (50% corn oil + 50% DMSO p...
March 29, 2023: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/36975210/evaluation-of-sida-cordifolia-and-sida-rhombifolia-extracts-in-a-rat-model-of-streptozotocin-induced-diabetic-nephropathy
#16
JOURNAL ARTICLE
Mohd Imran, Sahaya Mercy Jaquline Robert, Manju Sharma, Vidhu Aeri
BACKGROUND: Sida cordifolia and Sida rhombifolia are regarded as useful herbs as they have been shown to be effective, inexpensive and harmless in the prevention of diabetes, and are recognized as valuable therapeutic substances. OBJECTIVES: The purpose of this study was to assess the effect of S. cordifolia and S. rhombifolia in the treatment of diabetic nephropathy using a rat model. MATERIAL AND METHODS: Extracts of S. cordifolia and S...
March 28, 2023: Polimery W Medycynie
https://read.qxmd.com/read/36960265/evaluation-of-usage-of-a-fracture-risk-assessment-by-frax-tool-in-adults-with-type-2-diabetes-mellitus
#17
JOURNAL ARTICLE
Sílvia Santos Monteiro, Tiago da Silva Santos, Liliana Fonseca, Jorge Dores
BACKGROUND: Fragility fractures are increasingly recognized as a complication of type 2 diabetes mellitus (T2DM). The FRAX-Port® is a calculation tool that assesses the 10-year risk of either major and hip fracture, integrating several clinical risk factors, including T2DM. We aimed to evaluate the fracture risk in adults with T2DM and determine the rate of patients at high risk for fracture under anti-osteoporotic therapy. METHODS: We developed a cross-sectional study, including a convenience sample of adults with T2DM, followed in our tertiary center between 2019 and 2022...
February 2023: Curēus
https://read.qxmd.com/read/36901853/the-ppar-%C3%AE-agonist-pioglitazone-modulates-proliferation-and-migration-in-huvec-haosmc-and-human-arteriovenous-fistula-derived-cells
#18
JOURNAL ARTICLE
Carmen Ciavarella, Ilenia Motta, Francesco Vasuri, Teresa Palumbo, Anthony Paul Lisi, Alice Costa, Annalisa Astolfi, Sabrina Valente, Piera Versura, Eugenio F Fornasiero, Raffaella Mauro, Mauro Gargiulo, Gianandrea Pasquinelli
The failure of arteriovenous fistulas (AVFs) following intimal hyperplasia (IH) increases morbidity and mortality rates in patients undergoing hemodialysis for chronic kidney disease. The peroxisome-proliferator associated receptor (PPAR-γ) may be a therapeutic target in IH regulation. In the present study, we investigated PPAR-γ expression and tested the effect of pioglitazone, a PPAR-γ agonist, in different cell types involved in IH. As cell models, we used Human Endothelial Umbilical Vein Cells (HUVEC), Human Aortic Smooth Muscle Cells (HAOSMC), and AVF cells (AVFCs) isolated from (i) normal veins collected at the first AVF establishment (T0), and (ii) failed AVF with IH (T1)...
February 23, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36889200/synthesis-in-silico-studies-and-biological-evaluation-of-pyrimidine-based-thiazolidinedione-derivatives-as-potential-anti-diabetic-agent
#19
JOURNAL ARTICLE
Shaista Amin, Khursheed A Sheikh, Ashif Iqubal, Mohammad Ahmed Khan, M Shaquiquzzaman, Sharba Tasneem, Suruchi Khanna, A K Najmi, Mymoona Akhter, Anzarul Haque, Tarique Anwer, M Mumtaz Alam
Despite the advancements in the management of Diabetes mellitus, the design and synthesis of drug molecule which ameliorates the hyperglycemia and associated secondary complications in diabetic patients, still remains a challenge. Herein, we report the synthesis, characterization and anti-diabetic evaluation of pyrimidine-thiazolidinedione derivatives. The synthesized compounds were characterized by 1 H NMR, 13 C NMR, FTIR and Mass Spectroscopic analytical techniques. The in-silico ADME studies depicted that the compounds were within the permissible limits of the Lipinski's rule of five...
March 3, 2023: Bioorganic Chemistry
https://read.qxmd.com/read/36889064/peroxisome-proliferator-activated-receptor-%C3%A9-agonist-mediated-inhibition-of-heparanase-expression-reduces-proteinuria
#20
JOURNAL ARTICLE
Marjolein Garsen, Baranca Buijsers, Marloes Sol, Lena Gockeln, Ramon Sonneveld, Toin H van Kuppevelt, Mark de Graaf, Jacob van den Born, Jan A A M Kamps, Daniël H van Raalte, Rutger W van der Meer, Hildo J Lamb, Jan-Luuk Hillebrands, Ton J Rabelink, Marissa L Maciej-Hulme, Guido Krenning, Tom Nijenhuis, Johan van der Vlag
BACKGROUND: Proteinuria is associated with many glomerular diseases and a risk factor for the progression to renal failure. We previously showed that heparanase (HPSE) is essential for the development of proteinuria, whereas peroxisome proliferator-activated receptor ɣ (PPARɣ) agonists can ameliorate proteinuria. Since a recent study showed that PPARɣ regulates HPSE expression in liver cancer cells, we hypothesized that PPARɣ agonists exert their reno-protective effect by inhibiting glomerular HPSE expression...
March 6, 2023: EBioMedicine
keyword
keyword
92816
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.