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https://www.readbyqxmd.com/read/27888608/efficacy-and-safety-of-combined-intraventricular-fibrinolysis-with-lumbar-drainage-for-prevention-of-permanent-shunt-dependency-after-intracerebral-hemorrhage-with-severe-ventricular-involvement-a-randomized-trial-and-individual-patient-data-meta-analysis
#1
Dimitre Staykov, Joji B Kuramatsu, Jürgen Bardutzky, Bastian Volbers, Stefan T Gerner, Stephan P Kloska, Arnd Doerfler, Stefan Schwab, Hagen B Huttner
Objective Intraventricular hemorrhage (IVH) is a negative prognostic factor in intracerebral hemorrhage (ICH) and is associated with permanent shunt dependency in a substantial proportion of patients after ICH. IVH treatment by intraventricular fibrinolysis (IVF) was recently linked to reduced mortality rates in the CLEAR III study and IVF represents a safe and effective strategy to hasten clot resolution that may reduce shunt rates. Additionally, promising results from observational studies reported reductions in shunt dependency for a combined treatment approach of IVF plus lumbar drains (LD)...
November 26, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27863131/conditions-of-microvessel-occlusion-for-blood-coagulation-in-flow
#2
A Bouchnita, T Galochkina, P Kurbatova, P Nony, V Volpert
Vessel occlusion is a perturbation of blood flow inside a blood vessel because of the fibrin clot formation. As a result, blood circulation in the vessel can be slowed down or even stopped. This can provoke the risk of cardiovascular events. In order to explore this phenomenon, we used a previously developed mathematical model of blood clotting to describe the concentrations of blood factors with a reaction-diffusion system of equations. The Navier-Stokes equations were used to model blood flow and we treated the clot as a porous medium...
November 10, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27823634/purification-and-characterization-of-novel-fibrin-ogen-olytic-protease-from-curcuma-aromatica-salisb-role-in-hemostasis
#3
B R Shivalingu, H K Vivek, B S Priya, K N Soujanya, S Nanjunda Swamy
BACKGROUND: The proteases from turmeric species have procoagulant and fibrinogenolytic activity. This provides a scientific basis for traditional use of turmeric to stop bleeding and promote wound healing processes. PURPOSE: Our previous studies revealed that fibrinogenolytic action of crude enzyme fraction of Curcuma aromatica Salisb., was found to be more influential than those of Curcuma longa L., Curcuma caesia Roxb., Curcuma amada Roxb. and Curcuma zedoria (Christm...
December 1, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27803814/is-anticoagulation-discontinuation-achievable-with-citrate-dialysate-during-hdf-sessions
#4
Thibault Dolley-Hitze, Emmanuel Oger, Didier Hamel, Marie-Laure Lombart, Isabelle Hermès
Citrate dialysate has been developed for few years to replace acetate and HCl concentrates. In Online Postdilution Hemodiafiltration (OL-POST-HDF), several issues are remaining concerning the possibility of stopping anticoagulation during sessions and the side effects of citrate solutions on calcium metabolism. This 1-year monocentric retrospective study included all patients exposed to citrate in OL-POST-HDF with nadroparin decrease for more than one month. Clotting events, serum calcium, PTH, hemoglobin, CRP, depuration parameters, and treatments administrated were recorded for analysis...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27668535/potential-blood-clotting-factors-and-anticoagulants
#5
Ng Zhang Jin, Subash C B Gopinath
Hemostasis initiates a wound healing process and stops bleeding of blood within a damaged tissue, an important process in human and animal systems. However, this process needs to revert temporarily during surgery and analyze the clotting mechanism. In the past decade, heparin has been used widely as an anticoagulant in surgery to prevent unwanted blood clotting as it is not expensive, not difficult to control, lack of suitable replacement as well as less harmful to the human. However, heparin has several disadvantages, which include thrombocytopenia and non-specific plasma binding...
September 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27660900/is-stopping-heparin-safe-in-patients-on-extracorporeal-membrane-oxygenation-treatment
#6
Yoon Sang Chung, Dai Yun Cho, Dong Suep Sohn, Wang Soo Lee, Hoyoun Won, Dong Hoon Lee, Hyun Kang, Joonhwa Hong
Anticoagulation treatment during extracorporeal membrane oxygenation (ECMO) treatment is unavoidable. However, discontinuation of heparin infusion is necessary when challenges associated with the use of heparin, such as bleeding and thrombocytopenia, are encountered. The medical records of 94 adult (age ≥ 18 years) patients treated with ECMO from January 2011 to March 2015, at Chung-Ang University Hospital, Seoul, Korea, were reviewed. Among the 94 patients, 55 patients underwent ECMO treatment for 3 or more days...
September 20, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27650566/-the-role-of-rotational-thromboelastometry-rotem-in-the-perioperative-period-in-a-warfarinized-patient-case-report
#7
M Durila, J Schützner, T Vymazal
UNLABELLED: Warfarin overdose with unmeasurable values of the prothrombin time (PT-INR) is a significant problem in the preoperative preparation of the patient for acute invasive surgery. In contrast to conventional blood clotting assays, rotational thromboelastometry (ROTEM) evaluates the coagulation profile of the whole blood and provides a more complex view of the coagulation status of the patient. Thromboelastometry results are available within about 10 minutes and help us to provide targeted "bedside" therapy of coagulopathy in a bleeding patient...
2016: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/27515209/is-oral-contraceptive-induced-headache-dependent-on-patent-foramen-ovale-clinical-dynamics-evidence-based-hypothesis-and-possible-patient-oriented-management
#8
Benito Chiofalo, Antonio Simone Laganà, Giovanna Imbesi, Salvatore Giovanni Vitale, Ursula Catena, Federica Campolo, Gabriele Lanzo, Gabriele Centini, Onofrio Triolo
Secondary headache is one of the most common side effect during oral contraceptive (OC) treatment and it leads many patients to stop the therapy. Patent foramen ovale (PFO) is an interatrial communication that spontaneously closes at birth in about 75% of the population. However, in the rest of adults PFO maintains a direct communication between the right and left side of circulation. In these patients PFO is a tunnel-like structure that could allow a blood clot to pass from the right to the left side of circulation, thus can cause paradoxical embolization...
September 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27456749/heparin-binding-copolymer-reverses-effects-of-unfractionated-heparin-enoxaparin-and-fondaparinux-in-rats-and-mice
#9
Bartlomiej Kalaska, Kamil Kaminski, Joanna Miklosz, Shin-Ichi Yusa, Emilia Sokolowska, Agnieszka Blazejczyk, Joanna Wietrzyk, Irena Kasacka, Krzysztof Szczubialka, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
The parenteral anticoagulants may cause uncontrolled and life-threatening bleeding. Protamine, the only registered heparin antidote, is partially effective against low-molecular weight heparins, completely ineffective against fondaparinux and may cause unacceptable toxicity. Therefore, we aimed to develop a synthetic compound for safe and efficient neutralization of all parenteral anticoagulants. We synthesized pegylated PMAPTAC block copolymers, and then, we selected a lead heparin-binding copolymer (HBC)...
July 5, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27388764/idarucizumab-a-review-as-a-reversal-agent-for-dabigatran
#10
Yahiya Y Syed
Idarucizumab (Praxbind(®)), a humanized monoclonal antibody, is a specific reversal agent for the direct oral thrombin inhibitor dabigatran, available as its prodrug dabigatran etexilate (Pradaxa(®)). Idarucizumab is approved in several countries (including the USA, the EU, Canada and Australia) for use in adult patients on dabigatran when the reversal of its anticoagulant effects is required for emergency surgery/procedures or in the event of life-threatening or uncontrolled bleeding. In the ongoing pivotal RE-VERSE AD trial in these populations (n = 90), intravenous idarucizumab 5 g reversed dabigatran-induced prolongation of dilute thrombin time (dTT) and ecarin clotting time (ECT) within minutes...
August 2016: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/27256966/venovenous-extracorporeal-membrane-oxygenation-with-prophylactic-subcutaneous-anticoagulation-only-an-observational-study-in-more-than-60-patients
#11
Kirsten Krueger, Axel Schmutz, Barbara Zieger, Johannes Kalbhenn
Extracorporeal lung support and therapeutic anticoagulation are dogmatically linked for most clinicians in fear of clotting of the extracorporeal circuit. In the last decade, however, we have learned that bleeding complications in the course of extracorporeal membrane oxygenation (ECMO) therapy are common and not occasionally limiting or fatal. Even though international guidelines lowered the PTT-target values, ECMO therapy without anticoagulation has only been reported sporadically in case reports heretofore...
June 3, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27207416/flow-and-delta-p-dictate-where-thrombin-fibrin-and-von-willebrand-factor-will-be-found
#12
Scott L Diamond
Hemostasis occurs in two different topological scenarios: complete severing of a vessel or disruption of the vessel wall. Either to meet the daily rigors of active life or during an acute trauma, hemostasis involves the regulated and self-limiting production of thrombin to stop bleeding. In contrast, arterial and venous thrombosis typically involves the unregulated, intraluminal growth of a clot, in the absence of bleeding. For either hemostasis or thrombosis, the presence of flow and pressure gradients (delta-P, ΔP) dictates when and where thrombin and fibrin are located and in what quantity...
May 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27100752/coagulation-factor-concentrate-based-therapy-for-remote-damage-control-resuscitation-rdcr-a-reasonable-alternative
#13
Marc Maegele
The concept of remote damage control resuscitation (RDCR) is still in its infancy and there is significant work to be done to improve outcomes for patients with life-threatening bleeding secondary to injury. The prehospital phase of resuscitation is critical and if shock and coagulopathy can be rapidly minimized before hospital admission this will very likely reduce morbidity and mortality. The optimum transfusion strategy for these patients is still highly debated and the potential implications of the recently published pragmatic, randomize, optimal platelet, and plasma ratios trial (PROPPR) for RDCR have been reviewed...
April 2016: Transfusion
https://www.readbyqxmd.com/read/27055976/the-role-of-lipoprotein-a-in-clotting-reactions-during-lipoprotein-apheresis-a-case-report
#14
Kathryn Matney, Mary Berg, James M Falko, Nicole L Draper
In individuals with familial hypercholesterolemia (FH) who are unable to reach a target low-density lipoprotein level on a drug regimen, lipoprotein apheresis (LA) may be the treatment of choice. Severe reactions involving clotting during LA are not well described in the literature. We report a case of a 63-year-old woman with FH and markedly elevated lipoprotein(a) (Lp[a]) levels who experienced such a reaction while undergoing LA with a dextran-sulfate cellulose column on the Kaneka MA-01 Liposorber system...
March 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27015254/a-budget-impact-model-of-hemophilia-bypassing-agent-prophylaxis-relative-to-recombinant-factor-viia-on-demand
#15
Darshan A Mehta, Abiola O Oladapo, Joshua D Epstein, Aaron R Novack, Ellis J Neufeld, Joel W Hay
BACKGROUND: Hemophilia patients use factor-clotting concentrates (factor VIII for hemophilia A and factor IX for hemophilia B) for improved blood clotting. These products are used to prevent or stop bleeding episodes. However, some hemophilia patients develop inhibitors (i.e., the patient's immune system develops antibodies against these factor concentrates). Hence, these patients do not respond well to the factor concentrates. A majority of hemophilia patients with inhibitors are managed on-demand with the following bypassing agents: recombinant factor VIIa (rFVIIa) and activated prothrombin complex concentrate (aPCC)...
February 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27010641/optical-aggregometry-of-red-blood-cells-associated-with-the-blood-clotting-reaction-in-extracorporeal-circulation-support
#16
Daisuke Sakota, Ryo Kosaka, Masahiro Nishida, Osamu Maruyama
The aggregability of red blood cell (RBCs) is associated with the contribution of plasma proteins, such as fibrinogen and lipoproteids, to blood-clotting. Hence, we hypothesized that RBC aggregability reflects the blood-clotting reaction. A noninvasive optical monitoring method to measure RBC aggregability for the assessment of blood-clotting stage during mechanical circulatory support was developed. An in vitro thrombogenic test was conducted with a rotary blood pump using heparinized fresh porcine blood. Near-infrared laser light at a wavelength of 785 nm was guided by an optical fiber...
September 2016: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/26990599/repair-of-congenital-diaphragmatic-hernia-during-extracorporeal-life-support-experience-with-six-neonates
#17
Sudesh Prabhu, Adrian C Mattke, Ben Anderson, Craig McBride, Lucy Cooke, Tom Karl, Nelson Alphonso
BACKGROUND: The management of congenital diaphragmatic hernia (CDH) in neonates has evolved considerably over the last three decades. Initial stabilization followed by surgical repair is the current standard of care. A subset fails to achieve adequate oxygenation with medical management, including the use of high frequency oscillation and inhaled nitric oxide. The mortality in this group exceeds 80% without additional management strategies. Extracorporeal life support (ECLS) is a well-established modality for managing these neonates with CDH and has been shown to improve early survival in selected cases...
September 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/26988465/correlation-between-fix-genotype-and-pharmacokinetics-of-nonacog-alpha-according-to-a-multicentre-italian-study
#18
M Morfini, A Dragani, E Paladino, P Radossi, G Di Minno, M G Mazzucconi, G Rossetti, G Barillari, M Napolitano, G Tagariello
INTRODUCTION: Pharmacokinetic (PK) studies on recombinant FIX concentrate, Nonacog alpha, were conducted with different sampling time designs which gave rise to not complete and homogenous outcomes. In addition, patient's FIX genotype/PK relationship has never been investigated. AIM: Investigate how different sampling times may affect PK parameters and try to find a FIX genotype/PK relationship. PATIENTS AND METHODS: A cohort pharmacokinetic, Nonacog Alpha single-dose, open-label, non-comparative study was conducted in eight Comprehensive Care Haemophilia Centres in Italy...
July 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/26970218/manifestation-of-tranexamic-acid-toxicity-in-chronic-kidney-disease-and-kidney-transplant-patients-a-report-of-four-cases-and-review-of-literature
#19
Terry King-Wing Ma, Kai-Ming Chow, Bonnie Ching-Ha Kwan, Chi-Bon Leung, Cheuk Chun Szeto, Philip Kam-To Li
BACKGROUND: Tranexamic acid (TXA) is a synthetic anti-fibrinolytic agent commonly used for the prevention and treatment of bleeding disorders. Since renal excretion is the main route of elimination, patients with chronic kidney disease (CKD) are at risk of TXA toxicity. METHODS: From 2005 to 2014, we encountered four CKD patients who experienced severe complications related to TXA. Clinical manifestations and outcome of these patients were recorded. We then performed a qualitative literature review of published cases of TXA toxicity in CKD patients in the PubMed database from 1 January 1972 to 31 December 2015...
March 10, 2016: Nephrology
https://www.readbyqxmd.com/read/26959230/identification-of-analytical-factors-affecting-complex-proteomics-profiles-acquired-in-a-factorial-design-study-with-analysis-of-variance-simultaneous-component-analysis
#20
Vikram Mitra, Natalia Govorukhina, Gooitzen Zwanenburg, Huub Hoefsloot, Inge Westra, Age Smilde, Theo Reijmers, Ate G J van der Zee, Frank Suits, Rainer Bischoff, Péter Horvatovich
Complex shotgun proteomics peptide profiles obtained in quantitative differential protein expression studies, such as in biomarker discovery, may be affected by multiple experimental factors. These preanalytical factors may affect the measured protein abundances which in turn influence the outcome of the associated statistical analysis and validation. It is therefore important to determine which factors influence the abundance of peptides in a complex proteomics experiment and to identify those peptides that are most influenced by these factors...
April 19, 2016: Analytical Chemistry
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