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https://www.readbyqxmd.com/read/29932039/effect-of-prolonged-anti-hm1-imss-entamoeba-histolytica-antibody-activity-in-humoral-and-cellular-immunity-of-experimentally-induced-animal-model
#1
Swati Bagde, Vinod Singh
BACKGROUND: The Cellular immunity plays an important role in amoebic infections, whereas humoral immune responses have little influence on the outcome of the disease. Chronic infestation with E. histolytica, a common protozoan parasite, has been associated with autoimmune phenomena, including the appearance of antibodies to colonic epithelial cells. The mechanism whereby the protozoan parasite E. histolytica causes suppression of the immune response to allow it to survive in humans is unclear...
June 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29907099/loss-of-job-related-right-to-healthcare-associated-with-employment-turnover-challenges-for-the-mexican-health-system
#2
Germán Guerra, Emilio Gutiérrez-Calderón, Nelly Salgado de Snyder, Víctor Hugo Borja-Aburto, Adolfo Martínez-Valle, Miguel Ángel González-Block
BACKGROUND: The Mexican health system segments access and right to healthcare according to worker position in the labour market. In this contribution we analyse how access and continuity of healthcare gets interrupted by employment turnover in the labour market, including its formal and informal sectors, as experienced by affiliates to the Mexican Institute of Social Security (IMSS) at national level, and of workers with type 2 diabetes (T2DM) in Mexico City. METHODS: Using data from the National Employment and Occupation Survey, 2014, and from IMSS electronic medical records for workers in Mexico City, we estimated annual employment turnover rates to measure the loss of healthcare access due to labour market dynamics...
June 15, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29906025/malignant-tumors-as-cause-of-disability-at-the-instituto-mexicano-del-seguro-social
#3
Edgar Jesús Zitle-García, Alma Lucila Sauceda-Valenzuela, Iván de Jesús Ascencio-Montiel, Jesús García-Paredes
Background: Cancer represents an important issue in health, with the economic impact that it takes. The aim of this paper is to analyze the epidemiological characteristics of a population with social security who was diagnosed with some type of cancer and required a disability pension. Methods: Observational study, retrolective cohort type, carried out at the Instituto Mexicano del Seguro Social (IMSS) with IMSS beneficiaries ruled with a state of disability due to malignancy during the period 2006 to 2012...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29902370/the-instituto-mexicano-del-seguro-social-gives-dialysis-therapies-to-426-students-without-cost
#4
Antonio Méndez-Durán, Manuel Humberto Ignorosa-Luna, Gilberto Pérez-Aguilar, Francisco Jesús Rivera-Rodríguez, Luis Rafael López-Ocaña
Background: The Instituto Mexicano del Seguro Social (IMSS) is the institution with the greatest health coverage in Mexico. In adherence to existing and committed to provide specialized services to specific populations (vulnerable age groups, such as children and young people in primary, secondary and higher education, productive and without social security educational training), this gives the renal replacement therapy -peritoneal dialysis and hemodialysis- at no cost to students. Methods: Cross-sectional and retrospective study conducted from 1 to 30 September 2016; Census Patients with Chronical Renal Failure, sociodemographic and type of therapy are identified; direct costs are estimated...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29895448/risk-factors-for-acquiring-hcv-at-a-healthcare-center-in-hidalgo-mexico
#5
R Contreras-Omaña, F J García-Lemus, A García-Camacho
INTRODUCTION AND AIMS: The approach to HCV infection begins with the directed search for risk factors linked to its acquisition. Therefore, our primary aim was to identify the prevalence of risk factors associated with HCV infections in insured individuals seen at the Hidalgo delegation of the IMSS. MATERIALS AND METHODS: An observational, descriptive, cross-sectional study was conducted through validated surveys that identified major and minor risk factors. In cases of major risk factors, the Advanced Quality™ RAPID-ANTI-HCV TEST Accutrack® tests were applied to detect anti-HCV...
June 9, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29768584/mortality-from-type-2-diabetes-and-implementation-of-the-prevenimss-program-a-time-series-study-in-mexico-1998-2015
#6
Oswaldo Sinoe Medina-Gómez, Ismael Seth Medina-Reyes
Type 2 diabetes is the leading cause of morbidity and mortality in the world. In Mexico it is the first cause of mortality, disability, and potential years of life lost due to premature death. The Mexican Institute of Social Security (IMSS) implemented the PREVENIMSS strategy. The aim of the current study was to estimate the program's effect on the mortality trend from type 2 diabetes, based on an interrupted time series analysis. At the beginning of the target period, the diabetes mortality rate was higher in IMSS beneficiaries than in the control population...
May 10, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29735375/which-additional-augmented-fixation-procedure-decreases-surgical-failure-after-proximal-humeral-fracture-with-medial-comminution-fibular-allograft-or-inferomedial-screws
#7
Doo-Sup Kim, Doo-Hyung Lee, Yong-Min Chun, Sang-Jin Shin
BACKGROUND: The purpose of this study was to compare clinical and radiologic results between treatment with locking plate fixation and fibular allograft augmentation (FA) and treatment with locking plate fixation and additional inferomedial screws (IMSs) in 3- or 4-part proximal humeral fractures with medial comminution in geriatric patients. METHODS: We enrolled 164 patients with 3- or 4-part proximal humeral fractures with medial comminution who were treated with locking plates...
May 4, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29689063/estimation-of-the-marginal-effect-of-regular-drug-use-on-multiple-sclerosis-in-the-iranian-population
#8
Ibrahim Abdollahpour, Saharnaz Nedjat, Mohammad Ali Mansournia, Tibor Schuster
There are only few reports regarding the role of lifetime drug or substance use in multiple sclerosis (MS) etiology. In this study, we investigated the potential effect of drug or substance exposure on the onset of MS diagnosis. We conducted a population-based incident case control study in Tehran. Cases (n = 547) were 15-50 years old persons with MS identified from the Iranian Multiple Sclerosis Society (IMSS) register during August 7, 2013, and November 17, 2015. Population-based controls (n = 1057) were 15-50 years old and were recruited by random digit telephone dialing...
2018: PloS One
https://www.readbyqxmd.com/read/29684901/an%C3%A3-lisis-de-costo-de-la-enfermedad-del-tratamiento-las-complicaciones-e-intervenciones-de-la-hipercolesterolemia-en-m%C3%A3-xico-en-2016
#9
German Baeza-Cruz, Gustavo Peniche-Otero, Mónica E Alva-Esqueda, Mariana Naranjo-Muedano, Noé Soria-Suárez, Héctor J Morales-Flores
OBJETIVOS: Describir los costos y el impacto económico de la atención de pacientes diagnosticados con hipercolesterolemia en México en el año 2016. METODOLOGíA: Se desarrolla una evaluación económica del tipo análisis de costo de la enfermedad donde se cuantifican los recursos médicos utilizados para el tratamiento de la hipercolesterolemia así como para sus complicaciones. Los costos de los recursos médicos utilizados son obtenidos de los costos unitarios por nivel de atención del Instituto Mexicano del Seguro Social (IMSS) así como de las licitaciones publicadas en el portal de compras del IMSS...
April 20, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29680306/10-years-analysis-of-diabetes-related-major-lower-extremity-amputations-in-mexico
#10
Iván de Jesús Ascencio-Montiel
BACKGROUND: Little is known about diabetes-related major lower extremity amputations (DMLEA) burden in México. AIM OF THE STUDY: To describe DMLEA hospitalization rates, in-hospital survival rates, characteristics associated with all-cause in-hospital mortality and direct costs of hospitalization during the 2005-2015 period, in the two principal Health Institutions in Mexico: the Mexican Institute of Social Security (IMSS) and the Ministry of Health (MoH). METHODS: A secondary data analysis was conducted using hospital discharge information obtained from administrative databases...
April 18, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29624974/cost-of-hospitalizations-for-older-adults-at-one-imss-regional-general-hospital
#11
Víctor Granados-García, Sergio Sánchez-García, Ricardo Ramírez-Aldana, Carmen Zúñiga-Trejo, María Claudia Espinel-Bermúdez
Background: Population aging has a direct impact on the increasing demand of health services and on medical care costs. The objective was to carry out a cost analysis of health care costs in older adults in a regional general hospital of the Instituto Mexicano del Seguro Social. Methods: A calculation of the costs was done based on a retrospective collection of health care data. Unit prices were used to estimate costs. These were reported in 2016 Mexican pesos. A cost analysis was carried out by means of a regression model...
2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29624968/self-perception-of-oral-health-in-older-adults-from-mexico-city
#12
Ángel Cárdenas-Bahena, Laura Bárbara Velázquez-Olmedo, José Armando Falcón-Flores, Itzel Estela García-Zámano, Rosa Elena Montes-Salmerón, Gustavo Gil Reza-Bravo, Sergio Sánchez-García
Background: Quality of life related to oral health is assessed through the individual’s self-perceived oral health (SPOH). The objective is to determine SPOH in relation to socio-demographic and health characteristics in older adults beneficiaries from the Instituto Mexicano del Seguro Social (IMSS) in Mexico City. Methods: Cross-sectional study. We used data collection with questionnaire and assessment scales related to socio-demographic, health and dependency variables, as well as the visit to the dentist, the use of removable dental prostheses and SPOH...
2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29624362/reorganization-and-clinical-management-for-hypertension-control-at-primary-healthcare
#13
Paula Ramírez-Palacios, Katia Gallegos-Carrillo, Marcela Galicia-Naranjo, Daniela Antúnez-Albarrán, Jorge Montes-Alvarado, Luis Durán-Arenas
Background: In Mexico, 40% of hypertensive patients see their blood pressure under control. The evidence to keep hypertension (HT) under control is scarce, particularly in older adults who have the highest prevalence and require more health services. The objective was to determine the impact of a double intervention to increase the percentage of hypertensive patients with blood pressure levels under control and estimate differences among adults and older adults. Methods: Quasi-experimental design including reorganization and training to physicians using clinical guidelines in four primary healthcare units at the Instituto Mexicano del Seguro Social (IMSS)...
2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29624333/aging-and-health
#14
Sergio Sánchez-García
For the Instituto Mexicano del Seguro Social (IMSS), population aging represents a major challenge as a social security institution. This is why the Epidemiological Research and Health Care Services Unit/Aging Area has developed multi-disciplinary research concerning the older adult population, in order to contribute with programs of prevention, detection and attention of that age group and develop policies with plural perspective in which the voices of the older adults can be heard.
2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29623621/resources-and-costs-associated-with-the-treatment-of-advanced-and-metastatic-gastric-cancer-in-the-mexican-public-sector-a-patient-chart-review
#15
Miguel Quintana, José A Toriz, Diego Novick, Kyla Jones, Brenda S Botello, Juan Alejandro Silva
BACKGROUND: Little evidence is available on the management and cost of treating patients with advanced or metastatic gastric cancer (GC). This study evaluates patient characteristics, treatment patterns, and resource utilization for these patients in Mexico. METHODS: Data were collected from three centers of investigation (tertiary level). Patients were ≥18 years of age, diagnosed between 1 January 2009 and 1 January 2015, had advanced or metastatic GC, received first-line fluoropyrimidine/platinum, and had ≥3 months follow-up after discontinuing first-line treatment...
June 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29558734/synthesis-antiamoebic-activity-and-docking-studies-of-metronidazole-triazole-styryl-hybrids
#16
Beena Negi, Prija Poonan, Mohammad Fawad Ansari, Deepak Kumar, Sakshi Aggarwal, Ramandeep Singh, Amir Azam, Diwan S Rawat
A series of 22 novel metronidazole-triazole-styryl hybrids were synthesized and evaluated for their in vitro antiamoebic activity against HM1: IMSS strain of Entamoeba histolytica. Some of the hybrids were found to be more active (IC50  = 0.12-0.35 μM) than the reference drug metronidazole (IC50  = 1.79 μM). The most active compounds were found to be non-toxic (up to 50 μM) against the Vero cells showing a good safety profile of these hybrids. The docking and ADMET studies were also conducted to investigate the probable mode of action...
April 25, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29554130/aig1-affects-in-vitro-and-in-vivo-virulence-in-clinical-isolates-of-entamoeba-histolytica
#17
Kumiko Nakada-Tsukui, Tsuyoshi Sekizuka, Emi Sato-Ebine, Aleyla Escueta-de Cadiz, Dar-der Ji, Kentaro Tomii, Makoto Kuroda, Tomoyoshi Nozaki
The disease state of amebiasis, caused by Entamoeba histolytica, varies from asymptomatic to severe manifestations that include dysentery and extraintestinal abscesses. The virulence factors of the pathogen, and host defense mechanisms, contribute to the outcomes of infection; however, the underlying genetic factors, which affect clinical outcomes, remain to be fully elucidated. To identify these genetic factors in E. histolytica, we used Illumina next-generation sequencing to conduct a comparative genomic analysis of two clinical isolates obtained from diarrheal and asymptomatic patients (strains KU50 and KU27, respectively)...
March 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29432612/loss-of-job-related-right-to-healthcare-is-associated-with-reduced-quality-and-clinical-outcomes-of-diabetic-patients-in-mexico
#18
Svetlana V Doubova, Víctor Hugo Borja-Aburto, Germán Guerra-Y-Guerra, V Nelly Salgado-de-Snyder, Miguel Ángel González-Block
Objectives: The Mexican Institute of Social Security (IMSS) provides a package of health, economic and social benefits to workers employed in private firms within the formal labour market and to their economic dependants. Affiliates have a right to these benefits only while they remain contracted, thus posing a risk for the continuity of healthcare. This study evaluates the association between the time (in days) without the right to healthcare due to job loss in the formal labour market and the quality of healthcare and clinical outcomes among IMSS affiliates with Type 2 diabetes mellitus (T2DM)...
May 1, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29415659/increasing-prevalence-of-familial-recurrence-of-multiple-sclerosis-in-iran-a-population-based-study-of-tehran-registry-1999-2015
#19
Sharareh Eskandarieh, Narges Sistany Allahabadi, Malihe Sadeghi, Mohammad Ali Sahraian
BACKGROUND: Tehran is the capital of Iran with an increasing multiple sclerosis (MS) prevalence. A retrospective population-based study was conducted to evaluate the trends of MS prevalence in Tehran. METHODS: A population-based survey was conducted for the period 1999 to 2015, based on Iranian MS Society (IMSS) registry system of Tehran, the capital city of Iran. Point regression analysis was applied on MS trend data to find annual percent change (APC). The logistic regression analysis was used to estimate the odds ratio (OR) for individual variables in order to assess factors associating with familial recurrence of MS...
February 7, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29409117/comparison-of-secretome-profile-of-pathogenic-and-non-pathogenic-entamoeba-histolytica
#20
Chun-Seob Ahn, Jeong-Geun Kim, Myeong Heon Shin, Young Ah Lee, Yoon Kong
The obligatory intracellular protozoan parasite Entamoeba histolytica causes amebic dysentery and liver abscess. E. histolytica adheres to the host tissues in a contact-dependent manner. E. histolytica excretory-secretory products (ESP) might play critical roles during invasion. We comparatively analyzed the secretome profile of E. histolytica pathogenic HM-1:IMSS and non-pathogenic Rahman strains. The two ESP revealed similar but distinct spotting patterns. In both ESP, alcohol dehydrogenase, enolase 1, and transketolase, which control classical carbohydrate metabolism and other moonlighting effects, constituted the most abundant fractions...
April 2018: Proteomics
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