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Prognostic factor

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https://www.readbyqxmd.com/read/29792166/the-pdgfr%C3%AE-erk1-2-pathway-regulates-cdcp1-expression-in-triple-negative-breast-cancer
#1
Luca Forte, Federica Turdo, Cristina Ghirelli, Piera Aiello, Patrizia Casalini, Marilena Valeria Iorio, Elvira D'Ippolito, Patrizia Gasparini, Roberto Agresti, Beatrice Belmonte, Gabriella Sozzi, Lucia Sfondrini, Elda Tagliabue, Manuela Campiglio, Francesca Bianchi
BACKGROUND: CDCP1, a transmembrane protein with tumor pro-metastatic activity, was recently identified as a prognostic marker in TNBC, the most aggressive breast cancer subtype still lacking an effective molecular targeted therapy. The mechanisms driving CDCP1 over-expression are not fully understood, although several stimuli derived from tumor microenvironment, such as factors present in Wound Healing Fluids (WHFs), reportedly increase CDCP1 levels. METHODS: The expression of CDCP1, PDGFRβ and ERK1/2cell was tested by Western blot after stimulation of MDA-MB-231 cells with PDGF-BB and, similarly, in presence or not of ERK1/2 inhibitor in a panel of TNBC cell lines...
May 23, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29791927/treatment-outcome-of-reconstruction-for-isolated-posterior-cruciate-injury-subjective-and-objective-evaluations
#2
Satoshi Ochiai, Tetsuo Hagino, Shinya Senga, Takashi Yamashita, Hirotaka Haro
There is no consensus regarding the treatment method and outcome of posterior cruciate ligament (PCL) injury. We hypothesized that although the outcome of PCL reconstruction was favorable in terms of knee stability, the outcome was unsatisfactory in terms of patient-based assessments. The purpose of this study is to evaluate the treatment outcomes of knees that underwent reconstruction for PCL injury by subjective and objective assessments, and to analyze the correlation between various assessments. Twenty-three patients who underwent PCL reconstruction were studied...
May 23, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29791488/comparison-of-the-validity-of-smear-and-culture-conversion-as-a-prognostic-marker-of-treatment-outcome-in-patients-with-multidrug-resistant-tuberculosis
#3
Kefyalew Addis Alene, Kerri Viney, Hengzhong Yi, Emma S McBryde, Kunyun Yang, Liqiong Bai, Darren J Gray, Zuhui Xu, Archie C A Clements
BACKGROUND: The World Health Organization (WHO) has conditionally recommended the use of sputum smear microscopy and culture examination for the monitoring of multidrug-resistant tuberculosis (MDR-TB) treatment. We aimed to assess and compare the validity of smear and culture conversion at different time points during treatment for MDR-TB, as a prognostic marker for end-of-treatment outcomes. METHODS: We undertook a retrospective observational cohort study using data obtained from Hunan Chest Hospital, China and Gondar University Hospital, Ethiopia...
2018: PloS One
https://www.readbyqxmd.com/read/29791066/application-of-denaturing-capillary-electrophoresis-for-the-detection-of-prognostic-mutations-in-isocitrate-dehydrogenase-1-and-isocitrate-dehydrogenase-2-genes-in-brain-tumors
#4
Lucie Benesova, Barbora Belsanova, Filip Kramar, Tereza Halkova, Vladimir Benes, Marek Minarik
Malignant transformation in gliomas is frequently supplemented by somatic mutations in isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 genes. It has recently emerged that mutations in these genes are associated with prolonged survival and should be used as prognostic factor in management of brain cancer patients. There are several approaches in use for the detection of isocitrate dehydrogenase 1 and 2 mutations, however, these often exhibit shortcomings such as convoluted protocols with long processing time, complex (and costly) dedicated fluorescent probes and/or high demand on amounts of input DNA...
May 23, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29790934/pediatric-pituitary-adenomas-early-and-long-term-surgical-outcome-in-a-series-of-85-consecutive-patients
#5
Lina Raffaella Barzaghi, Marco Losa, Jody Filippo Capitanio, Luigi Albano, Giovanna Weber, Pietro Mortini
BACKGROUND: Young age has been reported as a negative prognostic factor for pituitary adenomas (PAs). They are very uncommon in children and adolescents; therefore, surgical outcomes are poorly described. OBJECTIVE: To report results of microsurgical transsphenoidal approach (MTSA) in pediatric PAs. METHODS: The study retrospectively analyzed 3040 PAs treated in our institute, according to the adenoma subtype and then divided into pediatric (≤18 yr) and adult groups (>18 yr)...
May 22, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29790692/serum-concentrations-of-vegf-and-bfgf-in-the-course-of-propranolol-therapy-of-infantile-hemangioma-in-children-are-we-closer-to-understand-the-mechanism-of-action-of-propranolol-on-hemangiomas
#6
Lidia Babiak-Choroszczak, Kaja Giżewska-Kacprzak, Elżbieta Gawrych, Katarzyna Fischer, Anna Walecka, Lidia Puchalska-Niedbał, Justyna Rajewska-Majchrzak, Maciej Bagłaj
BACKGROUND: Propranolol has become the treatment of choice for infantile hemangiomas (IH). Neither the pathogenesis of IH nor the mechanism of action of propranolol on them are well understood. Possible explanations include the inhibition of angiogenesis by decreasing vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), induction of vascular endothelial cell apoptosis and vasoconstriction. OBJECTIVES: The aim of the study was to assess serum concentrations of VEGF and bFGF in the course of propranolol therapy of IH in children, and to assess their clinical implications...
May 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790306/the-role-of-novel-prognostic-markers-prox1-and-foxc2-in-carcinogenesis-of-oral-squamous-cell-carcinoma
#7
Neha S Agnihotri, Madhusudan Astekar
Oral squamous cell carcinoma is the most common malignant tumor of the head and neck regions and accounts for more than 90% of cancers in the oral cavity. The angiogenesis, lymphangiogenesis and epithelial mesenchymal transition are known to be pivotal for tumor progression and metastasis. In the last decade, much data has been generated concerning the molecular mechanisms of angiogenesis, lymphangiogenesis and its significance in pathological conditions. The main angiogenic and lymphangiogenic factors have been identified as vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor receptor 2 (VEGFR-2), forkhead box (FOX) C2 while vascular endothelial growth factor C/D (VEGF-C/D), vascular endothelial growth factor receptor 3 (VEGFR-3), Prospero homeobox 1 (PROX1), LYVE-1, podoplanin, Tie/Angioprotein (Ang) 2 and EphrinB2 respectively...
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29790179/merkel-cell-carcinoma-clinical-outcome-and-prognostic-factors-in-351-patients
#8
Linde M van Veenendaal, Alexander C J van Akkooi, Cees Verhoef, Dirk Jan Grünhagen, W Martin C Klop, Gerlof D Valk, Margot E T Tesselaar
BACKGROUND: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine carcinoma of the skin. AIM: To describe clinical outcome and prognostic factors of MCC patients in two expert-centers. METHOD: Patients with histologically confirmed MCC in 1990-2014 were included. Data on patient, tumor characteristics and treatment were retrospectively collected. RESULTS: A total of 351 Patients were evaluated, 153 (44%) males, median age 74 years (range 28-94)...
May 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29790177/mri-based-emvi-positivity-predicts-systemic-recurrence-in-rectal-cancer-patients-with-a-good-tumor-response-to-chemoradiotherapy-followed-by-surgery
#9
Min Soo Cho, Youn Young Park, Jiho Yoon, Seung Yoon Yang, Seung Hyuk Baik, Kang Young Lee, Ik Yong Kim, Nam Kyu Kim
BACKGROUND: This study aimed to determine the prognostic value of baseline magnetic resonance imaging-based extramural vascular invasion status (EMVI) among rectal cancer patients with a good tumor response to standard chemoradiotherapy followed by surgery. METHODS: A total of 359 patients with ypT0-2/N0 disease from The Yonsei Multicenter Colorectal Cancer Electronic Database were retrospectively included between January 2000 and December 2014. Magnetic resonance images and medical records were reviewed to investigate risk factors for tumor recurrence...
May 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29790124/colorectal-cancer-why-does-side-matter
#10
Claire Gallois, Simon Pernot, Aziz Zaanan, Julien Taieb
Colorectal cancer (CRC) is a heterogeneous disease, and the search for clinical and molecular prognostic and predictive factors is thus necessary to better tailor each individual patient's management. Primary tumor location (PTL) seems to act as a master prognostic factor pooling different clinical, pathological, and molecular poor prognostic factors. In fact, right-sided (RS) CRC patients are more frequently female and elderly with microsatellite unstable, BRAF mutated, CpG island methylator phenotype (CIMP)-high, poorly differentiated tumors, compared to left-sided (LS) CRC patients...
May 22, 2018: Drugs
https://www.readbyqxmd.com/read/29789764/a-single-institution-analysis-of-low-dose-rate-brachytherapy-5-year-reported-survival-and-late-toxicity-outcomes
#11
REVIEW
Michael Chao, Sandra Spencer, Mario Guerrieri, Wei Ding, Mehran Goharian, Huong Ho, Michael Ng, Danielle Healey, Alwin Tan, Chee Cham, Daryl Lim Joon, Nathan Lawrentschuk, Douglas Travis, Shomik Sengupta, Yee Chan, Andrew Troy, Trung Pham, David Clarke, Peter Liodakis, Damien Bolton
Purpose: To report the 5-year biochemical relapse-free survival (BRFS), overall survival (OS), and long-term toxicity outcomes of patients treated with low-dose-rate (LDR) brachytherapy as monotherapy for low- to intermediate-risk prostate cancer. Material and methods: Between 2004 and 2011, 371 patients were treated with LDR brachytherapy as monotherapy. Of these, 102 patients (27%) underwent transurethral resection of the prostate (TURP) prior to implantation...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789493/critical-appraisal-of-advanced-glycation-end-products-ages-and-circulating-soluble-receptors-for-advanced-glycation-end-products-srage-as-a-predictive-biomarkers-for-cardiovascular-disease-in-hemodialysis-patients
#12
Adel M A Assiri, Hala F M Kamel, Abeer A ALrefai
The interaction of advanced glycation end products (AGE) and their receptors promote vascular complications of diabetes in hemodialysis (HD) patients. The soluble form of the receptor for the advanced glycation end-products (sRAGE) has been studied as a vascular biomarker in various diseases with controversial results. Our aim was to evaluate the association of the serum levels of the AGEs and their receptor sRAGE with cardiovascular disease (CVD) and the cardiovascular risk factors among HD patients. There were 130 HD patients and 80 age and gender matched control subjects were involved; 31...
May 22, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29789444/short-term-seizure-outcomes-in-childhood-epilepsy
#13
Kari Modalsli Aaberg, Inger Johanne Bakken, Morten I Lossius, Camilla Lund Søraas, Kamath K Tallur, Camilla Stoltenberg, Richard Chin, Pål Surén
BACKGROUND AND OBJECTIVES: Seizure freedom is the optimal response to antiepileptic treatment. In previous studies, it has been shown that between 61% and 71% of children with epilepsy achieve seizure freedom, whereas 7% to 20% have drug-resistant epilepsy. The definition of drug resistance has not been consistent across studies, and there is a lack of contemporary population-based data. We used data from a large nationwide child cohort to provide such information, implementing the current standard definition of drug resistance...
May 22, 2018: Pediatrics
https://www.readbyqxmd.com/read/29789351/development-and-validation-of-two-clinical-prediction-models-to-inform-clinical-decision-making-for-lumbar-spinal-fusion-surgery-for-degenerative-disorders-and-rehabilitation-following-surgery-protocol-for-a-prospective-observational-study
#14
Alison B Rushton, Martin L Verra, Andrew Emms, Nicola R Heneghan, Deborah Falla, Michael Reddington, Ashley A Cole, Paul Willems, Lorin Benneker, David Selvey, Michael Hutton, Martijn W Heymans, J Bart Staal
INTRODUCTION: Potential predictors of poor outcome will be measured at baseline: (1) preoperatively to develop a clinical prediction model to predict which patients are likely to have favourable outcome following lumbar spinal fusion surgery (LSFS) and (2) postoperatively to predict which patients are likely to have favourable long-term outcomes (to inform rehabilitation). METHODS AND ANALYSIS: Prospective observational study with a defined episode inception of the point of surgery...
May 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29789268/making-individual-prognoses-in-psychiatry-using-neuroimaging-and-machine-learning
#15
REVIEW
Ronald J Janssen, Janaina Mourão-Miranda, Hugo G Schnack
Psychiatric prognosis is a difficult problem. Making a prognosis requires looking far into the future, as opposed to making a diagnosis, which is concerned with the current state. During the follow-up period, many factors will influence the course of the disease. Combined with the usually scarcer longitudinal data and the variability in the definition of outcomes/transition, this makes prognostic predictions a challenging endeavor. Employing neuroimaging data in this endeavor introduces the additional hurdle of high dimensionality...
April 22, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29789186/a-population-based-assessment-of-depression-and-anxiety-in-patients-with-brachial-plexus-injuries
#16
Sarah M Yannascoli, Dustin Stwalley, Mohammed J Saeed, Margaret A Olsen, Christopher J Dy
PURPOSE: Reactive depression and anxiety are common after major life changes such as brachial plexus injuries (BPI). The purpose of this study was to evaluate the incidence and risk factors for coded depression and coded anxiety among patients with BPI using a national database of commercial insurance claims. METHODS: We used the Truven MarketScan database from 2007 to 2013 to identify commercially insured patients aged 18 to 64 years who underwent BPI surgery. For comparison, a control group without BPI was frequency-matched 10:1 by age group, sex, number of provider visits, and length of insurance enrollment...
May 19, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29789013/prognostic-significance-of-pd-l1-expression-and-cd8-t-cell-infiltration-in-pulmonary-neuroendocrine-tumors
#17
Haiyue Wang, Zhongwu Li, Bin Dong, Wei Sun, Xin Yang, Ruping Liu, Lixin Zhou, Xiaozheng Huang, Ling Jia, Dongmei Lin
BACKGROUND: Recent research supports a significant role of immune checkpoint inhibitors in the treatment of solid tumors. However, relevant reports for programmed death-ligand 1 (PD-L1) and CD8+ tumor-infiltrating lymphocytes (TILs) in pulmonary neuroendocrine tumors (PNETs) have not been fully studied. Therefore, we investigated PNETs for the expression of PD-L1 and infiltration by CD8+ TILs as well as the prognostic value of both factors. METHODS: In total, 159 specimens of PNETs (35 TC, 2 AC, 28 LCNEC, 94 SCLC) were included in this study...
May 22, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29788830/response-disease-free-interval-and-overall-survival-of-cats-with-nasal-planum-squamous-cell-carcinoma-treated-with-a-fractionated-vs-a-single-dose-protocol-of-strontium-plesiotherapy
#18
Davide Berlato, Sue Murphy, Silja Laberke, Sara Verganti
Objectives The main aim of the study was to establish response, disease-free interval (DFI) and overall survival of cats with nasal planum squamous cell carcinoma (SCC) treated with Sr90 plesiotherapy. A secondary aim was to determine whether a fractionated protocol is more effective than a single-dose protocol in terms of response, DFI and overall survival. The third aim was to evaluate whether we can identify prognostic factors that influence overall survival. Methods This was a retrospective study that included cats with a diagnosis of nasal planum SCC treated with Sr90 plesiotherapy at a single institution...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29788741/foxa1-and-ck7-expression-in-esophageal-squamous-cell-carcinoma-and-its-prognostic-significance
#19
Y Xu, W Wang, L Li, J Liu, X Wu, J Yu, H Wang, W Cui, R Zhang
Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors in human. Some ESCC cells express adenocarcinoma cell markers, such as Cytokeratin 7 (CK7), but the clinical significance of these cells in ESCC is unknown. Immunohistochemical analysis of CK7 and Fork head box protein A1(FOXA1, an upstream regulator of CK7) was performed on 610 ESCC specimens using tissue microarray. In total, positive staining of CK7 was 59/594 (10%). CK7 expression was correlated with ESCC differentiation (P=0...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29788230/tumor-infiltrating-lymphocytes-in-patients-receiving-trastuzumab-pertuzumab-based-chemotherapy-a-tryphaena-substudy
#20
Michail Ignatiadis, Gert Van den Eynden, Salgado Roberto, Marco Fornili, Yacine Bareche, Christine Desmedt, Françoise Rothé, Marion Maetens, David Venet, Esther Holgado, Virginia McNally, Astrid Kiermaier, Heidi M Savage, Timothy R Wilson, Javier Cortes, Andreas Schneeweiss, Karen Willard-Gallo, Elia Biganzoli, Christos Sotiriou
Background: There is an urgent requirement to identify biomarkers to tailor treatment in human epidermal growth factor receptor 2 (HER2)-amplified early breast cancer treated with trastuzumab/pertuzumab-based chemotherapy. Methods: Among the 225 patients randomly assigned to trastuzumab/pertuzumab concurrently or sequentially with an anthracycline-containing regimen or concurrently with an anthracycline-free regimen in the Tryphaena trial, we determined the percentage of tumor-infiltrating lymphocytes (TILs) at baseline in 213 patients, of which 126 demonstrated a pathological complete response (pCR; ypT0/is ypN0), with 28 demonstrating event-free survival (EFS) events...
May 18, 2018: Journal of the National Cancer Institute
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