Rebecca L Joyce, Gareth R Tibbs, J David Warren, Christopher J Costa, Kelly Aromolaran, R Lea Sanford, Olaf S Andersen, Zhucui Li, Guoan Zhang, Dianna E Willis, Peter A Goldstein
2,6-di- tert -butylphenol (2,6-DTBP) ameliorates mechanical allodynia and thermal hyperalgesia produced by partial sciatic nerve ligation in mice, and selectively inhibits HCN1 channel gating. We hypothesized that the clinically utilized non-anesthetic dimerized congener of 2,6-DTBP, probucol (2,6-di- tert -butyl-4-[2-(3,5-di- tert -butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol), would relieve the neuropathic phenotype that results from peripheral nerve damage, and that the anti-hyperalgesic efficacy in vivo would correlate with HCN1 channel inhibition in vitro...
2023: Neurobiology of Pain