Nicholas Jex, John P Greenwood, Richard M Cubbon, Oliver J Rider, Amrit Chowdhary, Sharmaine Thirunavukarasu, Sindhoora Kotha, Marilena Giannoudi, Anna McGrane, Amanda Maccannell, Marcella Conning-Rowland, Sam Straw, Henry Procter, Sotiris Papaspyros, Betsy Evans, Kalyana Javangula, Antonella Ferrara, Walid Elmahdy, Pankaj Kaul, Hui Xue, Peter Swoboda, Peter Kellman, Ladislav Valkovič, Lee Roberts, David Beech, Mark T Kearney, Sven Plein, Marc R Dweck, Eylem Levelt
BACKGROUND: Type 2 diabetes (T2D) is associated with an increased risk of left ventricular dysfunction after aortic valve replacement (AVR) in patients with severe aortic stenosis (AS). Persistent impairments in myocardial energetics and myocardial blood flow (MBF) may underpin this observation. Using phosphorus magnetic resonance spectroscopy and cardiovascular magnetic resonance, this study tested the hypothesis that patients with severe AS and T2D (AS-T2D) would have impaired myocardial energetics as reflected by the phosphocreatine to ATP ratio (PCr/ATP) and vasodilator stress MBF compared with patients with AS without T2D (AS-noT2D), and that these differences would persist after AVR...
September 25, 2023: Circulation