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Xu Zhao, Jing Yu
OBJECTIVE: To assess the efficacy and safety of a novel hormone therapy, drospirenone combined with 17-β-estradiol (DRSP/E2) in postmenopausal hypertensive women. DESIGN AND METHOD: A systemic literature search of PubMed, Embase, Cochrane Library, Web of Science (up to Oct. 2015) was performed. Studies were screened independently by two researchers according to the inclusion and exclusion criteria which included only the randomized controlled trials (RCT) about the drospirenone with 17-β-estradiol for postmenopausal women with hypertension...
September 2016: Journal of Hypertension
Shaoxiao Wang, Siyuan Zhang, Chuan Xu, Addie Barron, Floyd Galiano, Dhaval Patel, Yong Joo Lee, Guy A Caldwell, Kim A Caldwell, Stephan N Witt
We have been investigating the role that phosphatidylethanolamine (PE) and phosphatidylcholine (PC) content plays in modulating the solubility of the Parkinson's disease protein alpha-synuclein (α-syn) using Saccharomyces cerevisiae and Caenorhabditis elegans. One enzyme that synthesizes PE is the conserved enzyme phosphatidylserine decarboxylase (Psd1/yeast; PSD-1/worms), which is lodged in the inner mitochondrial membrane. We previously found that decreasing the level of PE due to knockdown of Psd1/psd-1 affects the homeostasis of α-syn in vivo...
2016: PloS One
Jessyca Couto Otoni, Julia Noschang, Thábata Yaedu Okamoto, Diego Rosseman Vieira, Michel Souto Mayor Petry, Lucas de Araujo Ramos, Paula Nicole Vieira Pinto Barbosa, Almir Galvão Vieira Bitencourt, Rubens Chojniak
To evaluate the imaging methods used at the emergency department (ED) of a cancer center, with emphasis on computed tomography (CT). A descriptive, retrospective, single-center study was conducted by reviewing imaging exams and medical records, after approval of the institution's Ethics Review Board. The demographic data, cancer history, and imaging exam requested were evaluated for all patients and the indications and results of head, chest, and abdominopelvic CT scans were also evaluated. During the study period, there were 8710 visits to the ED, and 5999 imaging studies were requested in 3788 patients (43...
October 8, 2016: Emergency Radiology
Anne M Lynch, Brandie D Wagner, Naresh Mandava, Alan G Palestine, Peter M Mourani, Emily A McCourt, Scott C N Oliver, Steven H Abman
Purpose: Retinopathy of prematurity (ROP) is a vision-threatening disease associated with abnormal retinal vascular development. Proteins from the insulin-like growth factor pathway are related to ROP. However, there is a paucity of research on the role of other proteins in ROP. The aim of this study was to identify plasma proteins related to clinically significant ROP. Methods: We measured 1121 plasma proteins in the early neonatal period in infants at risk for ROP using an aptamer-based proteomic technology...
September 1, 2016: Investigative Ophthalmology & Visual Science
Xu Zhao, Jing Yu
OBJECTIVE: To assess the efficacy and safety of a novel hormone therapy, drospirenone combined with 17-β-estradiol (DRSP/E2) in postmenopausal hypertensive women. DESIGN AND METHOD: A systemic literature search of PubMed, Embase, Cochrane Library, Web of Science (up to Oct. 2015) was performed. Studies were screened independently by two researchers according to the inclusion and exclusion criteria which included only the randomized controlled trials (RCT) about the drospirenone with 17-β-estradiol for postmenopausal women with hypertension...
September 2016: Journal of Hypertension
I Vagner, C Varlam, I Faurescu, D Faurescu, D Bogdan, F Bucura
The method consisted in combustion, using a Parr bomb type 1121, of a sediment - tritium free promoter mixture. The proper ratio sediment to promoter in our experiments was between 1:3 and 1:2, higher ratio resulting in unreliable results, due to incomplete combustion of the sample. The described method was used to measure the estuarine sediment sample from the 2nd International OBT Intercomparison Exercise, the average reported value being 163±12Bqkg(-1) dry matter (k=2).
September 9, 2016: Applied Radiation and Isotopes
Dhelio Pereira, André Daher, Graziela Zanini, Ivan Maia, Lais Fonseca, Luciana Pitta, Rosilene Ruffato, Paola Marchesini, Cor Jesus Fontes
BACKGROUND: Malaria remains a major public health problem, with half the world population at risk of contracting malaria. The effects of Plasmodium vivax on prosperity and longevity have been highlighted in several recent clinical case reports. The first line of vivax treatment drugs has seen no radical innovation for more than 60 years. This study introduces a subtle incremental innovation to vivax treatment: a chloroquine and primaquine co-blister. The co-blister includes a new chloroquine formulation incorporating coated tablets to mask the drug's bitter taste and user-friendly packaging containing tablets of each drug, which may improve patient adherence and facilitate the appropriate use of the drugs...
2016: Malaria Journal
R Abdul Fiyaz, Ashutosh K Yadav, S Gopala Krishnan, Ranjith K Ellur, Bishnu M Bashyal, Nitasha Grover, Prolay K Bhowmick, M Nagarajan, K K Vinod, Nagendra K Singh, Kumble V Prabhu, Ashok K Singh
BACKGROUND: Bakanae or foot rot disease caused by Fusarium fujikuroi [teleomorph: Gibberella fujikuroi (Sawada) Ito] is emerging as a serious disease in rice. The disease causes both quantitative and qualitative losses to the grains under the field conditions. Breeding for resistance to Bakanae disease is a promising strategy to manage this emerging disease. In this study, we used a population of 168 F14 recombinant inbred lines (RILs) derived from two indica rice parents Pusa 1342, a highly resistant variety and Pusa Basmati 1121, a highly susceptible variety to map quantitative trait loci (QTLs) governing resistance against Bakanae disease...
December 2016: Rice
Matthew J Maurice, Daniel Ramirez, Ryan J Nelson, Peter A Caputo, Önder Kara, Ercan Malkoç, Jihad H Kaouk
INTRODUCTION: The surgical morbidity of ipsilateral synchronous multifocality (ISM) is poorly characterized. We assessed the impact of ISM on complications after robotic partial nephrectomy (RPN). PATIENTS AND METHODS: We abstracted data on RPN cases performed between 2006 and 2015 at our institution. Multifocal disease was characterized by >1 renal mass on preoperative imaging or >1 mass excision during RPN. The primary outcome was the rate of overall postoperative complications...
October 3, 2016: Journal of Endourology
Aaron S Farberg, Adam C Rigel, Darrell S Rigel
The American Academy of Dermatology and dermatologists' themselves, have recommended public education and patient counseling regarding sunscreen. The purpose of this study was to determine US dermatologists' actual sunscreen perceptions as well as their recommendations and personal usage. 540 practicing US dermatologists responded to an online survey that assessed each physician's perception of safety and efficacy of sunscreen, recommendation factors, and personal usage. Dermatologists have an overall positive view of sunscreen...
September 1, 2016: Journal of Drugs in Dermatology: JDD
Duane B Corbett, Amal Wanigatunga, Vincenzo Valiani, Eileen Handberg, Christopher Janelle, Todd M Manini
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Njeri Wabiri, Matthew Chersich, Olive Shisana, Duane Blaauw, Helen Rees, Ntabozuko Dwane
BACKGROUND: Rates of maternal mortality and morbidity vary markedly, both between and within countries. Documenting these variations, in a very unequal society like South Africa, provides useful information to direct initiatives to improve services. The study describes inequalities over time in access to maternal health services in South Africa, and identifies differences in maternal health outcomes between population groups and across geographical areas. METHODS: Data were analysed from serial population-level household surveys that applied multistage-stratified sampling...
2016: BMC Pregnancy and Childbirth
Rebecca K Randell, Ian Rollo, Timothy J Roberts, Kortney Dalrymple, Asker E Jeukendrup, James M Carter
INTRODUCTION: The aim of this study was to describe maximal fat oxidation (MFO) rates in an athletic population. METHOD: In total, 1121 athletes (933 males, 188 females), from a variety of sports and competitive level, undertook a graded exercise test on a treadmill in a fasted state (≥5 h fasted). Rates of fat oxidation were determined using indirect calorimetry. RESULTS: Average MFO was 0.59 ± 0.18 g[BULLET OPERATOR]min, ranging from 0...
August 29, 2016: Medicine and Science in Sports and Exercise
Fei Zhou, Li-Xin Qiu, Lei Cheng, Meng-Yun Wang, Jin Li, Meng-Hong Sun, Ya-Jun Yang, Jiu-Cun Wang, Li Jin, Ya-Nong Wang, Qing-Yi Wei
Interleukin-17 plays a crucial role in inflammation-related carcinogenesis. We hypothesize that genetic variants in IL-17 are associated with gastric cancer (GCa) risk, and we genotyped five potentially functional single nucleotide polymorphisms (SNPs) (rs1974226 G > A, rs2275913 A > G, rs3819024 A > G, rs4711998 A > G, and rs8193036 C > T) of IL-17 in 1121 GCa patients and 1216 cancer-free controls in an eastern Chinese population. Logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI)...
August 25, 2016: Oncotarget
Christine de la Loge, Svetlana Dimova, Knut Mueller, George Phillips, Tracy L Durgin, Paul Wicks, Simon Borghs
OBJECTIVE: The online PatientsLikeMe® Epilepsy Community allows patients with epilepsy to record, monitor, and share their demographic, disease, and treatment characteristics, providing valuable insights into patient perceptions and understanding of epilepsy. The objective of this retrospective analysis was to characterize the profile of users and their disease and identify factors predictive of poor health-related quality of life (HRQoL), while assessing the platform's potential in providing patient-reported data for research purposes...
October 2016: Epilepsy & Behavior: E&B
Magnus P Lindgren, J Gustav Smith, Xinjun Li, Jan Sundquist, Kristina Sundquist, Bengt Zöller
BACKGROUND: The familial risks of heart failure (HF) remain largely undetermined. This nationwide follow-up study aimed at determining risk of hospitalization for HF conferred by affected siblings. METHODS AND RESULTS: Swedish Multi-generation Register data, with records of at least one full sibling available at start of follow-up, were linked to the Hospital Discharge Register data for 1987-2010. The oldest participants were aged 78years in 2010. Relative risks, standardized incidence ratios (SIRs), of HF hospitalization were calculated for individuals with siblings hospitalized with HF compared with those whose siblings were not...
November 15, 2016: International Journal of Cardiology
G Emanuel, J Charlton, M Ashworth, M C Gulliford, A Dregan
OBJECTIVE: To compare differences in cardiovascular (CV) risk factors assessment and management among patients with rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) with that of matched controls. METHODS: A matched cohort study was conducted using primary care electronic health records for one London borough. All patients diagnosed with RA or IBD, and matched controls registered with local general practices on 12th of January 2014 were identified. The study compared assessment and treatment of CV risk factors (blood pressure, body mass index, cholesterol and smoking) in the year before, the year after, and 5 years after RA and IBD diagnosis...
August 17, 2016: Heart: Official Journal of the British Cardiac Society
S Biffani, M Del Corvo, R Capoferri, A Pedretti, M Luini, J L Williams, G Pagnacco, F Minvielle, G Minozzi
The possibility of using genetic control strategies to increase disease resistance to infectious diseases relies on the identification of markers to include in the breeding plans. Possible incomplete exposure of mastitis-free (control) animals, however, is a major issue to find relevant markers in genetic association studies for infectious diseases. Usually, designs based on elite dairy sires are used in association studies, but an epidemiological case-control strategy, based on cows repeatedly field-tested could be an alternative for disease traits...
August 18, 2016: Animal: An International Journal of Animal Bioscience
Chao Li, Jianjun Sun, Qian Xiang, Yan Liang, Nan Zhao, Zhuo Zhang, Qianxin Liu, Yimin Cui
MicroRNA-21 (miRNA-21) has recently been shown to be a promising prognostic tumor biomarker. However, few studies have not supported this idea and have shown inconsistent data. Thus, we conducted a meta-analysis to elucidate the predictive value of miRNA-21 in gliomas. The relevant studies were identified by performing online search in PubMed, EMBASE and Web of Science databases up to Apr 2016. This meta-analysis study included seven eligible studies, consisting of 1121 gliomas and 533 glioblastoma multiforme (GBM) patients...
August 16, 2016: Journal of Neuro-oncology
Ranjith K Ellur, Apurva Khanna, Gopala Krishnan S, Prolay K Bhowmick, K K Vinod, M Nagarajan, Kalyan K Mondal, Nagendra K Singh, Kuldeep Singh, Kumble Vinod Prabhu, Ashok K Singh
Basmati rice is preferred internationally because of its appealing taste, mouth feel and aroma. Pusa Basmati 1121 (PB1121) is a widely grown variety known for its excellent grain and cooking quality in the international and domestic market. It contributes approximately USD 3 billion to India's forex earning annually by being the most traded variety. However, PB1121 is highly susceptible to bacterial blight (BB) disease. A novel BB resistance gene Xa38 was incorporated in PB1121 from donor parent PR114-Xa38 using a modified marker-assisted backcross breeding (MABB) scheme...
2016: Scientific Reports
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