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https://www.readbyqxmd.com/read/28680934/improving-rational-thermal-comfort-prediction-by-using-subpopulation-characteristics-a-case-study-at-hermitage-amsterdam
#1
Rick Kramer, Lisje Schellen, Henk Schellen, Boris Kingma
This study aims to improve the prediction accuracy of the rational standard thermal comfort model, known as the Predicted Mean Vote (PMV) model, by (1) calibrating one of its input variables "metabolic rate," and (2) extending it by explicitly incorporating the variable running mean outdoor temperature (RMOT) that relates to adaptive thermal comfort. The analysis was performed with survey data (n = 1121) and climate measurements of the indoor and outdoor environment from a one year-long case study undertaken at Hermitage Amsterdam museum in the Netherlands...
2017: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/28674415/mboat7-rs641738-variant-and-hepatocellular-carcinoma-in-non-cirrhotic-individuals
#2
Benedetta Donati, Paola Dongiovanni, Stefano Romeo, Marica Meroni, Misti McCain, Luca Miele, Salvatore Petta, Silvia Maier, Chiara Rosso, Laura De Luca, Ester Vanni, Stefania Grimaudo, Renato Romagnoli, Fabio Colli, Flaminia Ferri, Rosellina Margherita Mancina, Paula Iruzubieta, Antonio Craxi, Anna Ludovica Fracanzani, Antonio Grieco, Stefano Ginanni Corradini, Alessio Aghemo, Massimo Colombo, Giorgio Soardo, Elisabetta Bugianesi, Helen Reeves, Quentin M Anstee, Silvia Fargion, Luca Valenti
Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C > T MBOAT7/TMC4 variant predisposes to progressive NAFLD, but the impact on hepatic carcinogenesis is unknown. In Italian NAFLD patients, the rs641738 T allele was associated with NAFLD-HCC (OR 1.65, 1.08-2.55; n = 765), particularly in those without advanced fibrosis (p < 0.001). The risk T allele was linked to 3'-UTR variation in MBOAT7 and to reduced MBOAT7 expression in patients without severe fibrosis...
July 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28660146/bile-cast-nephropathy-in-patients-with-acute-kidney-injury-due-to-hepatorenal-syndrome-a-postmortem-kidney-biopsy-study
#3
Suman Lata Nayak, Manoj Kumar, Chhagan Bihari, Archana Rastogi
Background and Aims: The role of bile cast nephropathy (BCN) in pathogenesis of hepatorenal syndrome (HRS) in decompensated cirrhosis and acute on chronic liver failure (ACLF) is unknown. This study aimed to determine the frequency of BCN detected on postmortem renal biopsy among patients with decompensated cirrhosis and ACLF who had been admitted with acute kidney injury due to HRS (HRA-AKI) and expired during that hospitalization. Methods: One-hundred-twenty-seven postmortem renal biopsies with adequate size (>1 cm in length) were included for analysis...
June 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28642559/little-evidence-to-support-or-refute-interventions-for-the-management-of-burning-mouth-syndrome
#4
Debra K Fischoff, Silvia Spivakovsky
Data sourcesCochrane Oral Health's Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), Medline Ovid, Embase Ovid, US National Institutes of Health Ongoing Trials Register (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform. Handsearch of the proceedings from the British Society for Oral Medicine (BSOM), British Society for Dental Research (BSDR) and the International Association for Dental Research (IADR).Study selectionAll included studies were randomised placebo controlled trials comparing a treatment to placebo with no language or year of publication restrictions...
June 23, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28587264/being-in-the-chemotherapy-suite-versus-being-in-the-oncology-ward-an-analytical-view-of-two-hospital-sites-occupied-by-people-experiencing-cancer
#5
Catherine Hughes, Kate van Heugten, Sally Keeling, Francisc Szekely
How do people with cancer occupy places within the health system during their journey through palliative care? The answer to this question was explored by the authors as part of a wider ethnographic study of eight people's journeys from referral to palliative care services to the end of life. This article reports on findings that have emerged from ongoing analysis that has been completed in the years proceeding data collection. An ethnographic research design was used to collect data about the participants and their family members over a three-year period...
June 5, 2017: Cancers
https://www.readbyqxmd.com/read/28586207/primadorac-a-free-web-interface-for-the-assignment-of-partial-charges-chemical-topology-and-bonded-parameters-in-organic-or-drug-molecules
#6
Piero Procacci
We present PrimaDORAC, a simple and freely accessible web interface for generating the topology and the parameter files of organic or drug molecules to be used in molecular mechanics or molecular dynamics calculations. The interface relies on our in-house FORTRAN90 parser, working on the recently released Generalized Amber Force Field parameter set (GAFF2). AM1/BCC charges are computed using the Public Domain MOPAC7 program and the bond charge corrections (BCC) reported in Jakalian, A.; Jack, D. B.; Bayly, C...
June 14, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28555474/fine-scale-mapping-of-malaria-infection-clusters-by-using-routinely-collected-health-facility-data-in-urban-dar-es-salaam-tanzania
#7
Yeromin P Mlacha, Prosper P Chaki, Alpha D Malishee, Victoria M Mwakalinga, Nicodem J Govella, Alex J Limwagu, John M Paliga, Daniel F Msellemu, Zawadi D Mageni, Dianne J Terlouw, Gerry F Killeen, Stefan Dongus
This study investigated whether passively collected routine health facility data can be used for mapping spatial heterogeneities in malaria transmission at the level of local government housing cluster administrative units in Dar es Salaam, Tanzania. From June 2012 to January 2013, residential locations of patients tested for malaria at a public health facility were traced based on their local leaders' names and geo-referencing the point locations of these leaders' houses. Geographic information systems (GIS) were used to visualise the spatial distribution of malaria infection rates...
May 11, 2017: Geospatial Health
https://www.readbyqxmd.com/read/28550466/schizophrenia-symptomatic-associations-with-diffusion-tensor-imaging-measured-fractional-anisotropy-of-brain-a-meta-analysis
#8
Xu Yang, Ding Cao, Xiumei Liang, Jiannong Zhao
PURPOSE: Several studies have examined the relationships between diffusion tensor imaging (DTI)-measured fractional anisotropy (FA) and the symptoms of schizophrenia, but results vary across the studies. The aim of this study was to carry out a meta-analysis of correlation coefficients reported by relevant studies to evaluate the correlative relationships between FA of various parts of the brain and schizophrenia symptomatic assessments. METHODS: Literature was searched in several electronic databases, and study selection was based on précised eligibility criteria...
May 26, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28549434/the-potential-of-task-shifting-in-scaling-up-services-for-prevention-of-mother-to-child-transmission-of-hiv-a-time-and-motion-study-in-dar-es-salaam-tanzania
#9
Helga Naburi, Anna Mia Ekström, Phares Mujinja, Charles Kilewo, Karim Manji, Gunnel Biberfeld, David Sando, Guerino Chalamila, Till Bärnighausen
BACKGROUND: In many African countries, prevention of mother-to-child transmission of HIV (PMTCT) services are predominantly delivered by nurses. Although task-shifting is not yet well established, community health workers (CHWs) are often informally used as part of PMTCT delivery. According to the 2008 World Health Organization (WHO) Task-shifting Guidelines, many PMTCT tasks can be shifted from nurses to CHWs. METHODS: The aim of this time and motion study in Dar es Salaam, Tanzania, was to estimate the potential of task-shifting in PMTCT service delivery to reduce nurses' workload and health system costs...
May 26, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28517022/impact-and-management-of-left-ventricular-function-on-the-prognosis-of-takotsubo-syndrome
#10
Ibrahim El-Battrawy, Uzair Ansari, Siegfried Lang, Michael Behnes, Katja Schramm, Christian Fastner, Xiaobo Zhou, Jürgen Kuschyk, Erol Tülümen, Susanne Röger, Martin Borggrefe, Ibrahim Akin
BACKGROUND: Early research has proposed that patients with Takotsubo syndrome (TTS) could have a higher mortality rate than the general population. Our study was conducted to determine the short- and long-term outcome of TTS patients associated with a significantly compromised left ventricular function on hospital admission. MATERIALS AND METHODS: Our institutional database constituted a collective of 112 patients diagnosed with TTS between 2003 and 2015. The patients were classified into two groups based on the left ventricular ejection fraction (LVEF), with those presenting with a LVEF > 35% on admission categorized into one group (n = 65, 58%) and those presenting with LVEF ≤ 35% (n=47, 42%) categorized into another group...
May 18, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28485570/tuning-porosity-and-surface-area-in-mesoporous-silicon-for-application-in-li-ion-battery-electrodes
#11
John B Cook, Hyung-Seok Kim, Terri C Lin, Shauna Robbennolt, Eric Detsi, Bruce S Dunn, Sarah H Tolbert
This work aims to improve the poor cycle lifetime of silicon-based anodes for Li-ion batteries by tuning microstructural parameters such as pore size, pore volume, and specific surface area in chemically synthesized mesoporous silicon. Here we have specifically produced two different mesoporous silicon samples from the magnesiothermic reduction of ordered mesoporous silica in either argon or forming gas. In situ X-ray diffraction studies indicate that samples made in Ar proceed through a Mg2Si intermediate, and this results in samples with larger pores (diameter ≈ 90 nm), modest total porosity (34%), and modest specific surface area (50 m(2) g(-1))...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28467231/smoking-behaviors-among-adolescents-in-foster-care-a-gender-based-analysis
#12
Svetlana Shpiegel, Steve Sussman, Scott E Sherman, Omar El Shahawy
BACKGROUND AND OBJECTIVES: Adolescents in foster care are at high risk for cigarette smoking. However, it is not clear how their smoking behaviors vary by gender. The present study examined lifetime and current smoking among males and females, and explored gender-specific risk factors for engagement in smoking behaviors. METHOD: Data from the Multi Site Evaluation of Foster Youth Programs was used to evaluate patterns of smoking among adolescents aged 12-18 years (N = 1121; 489 males, 632 females)...
May 3, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28464035/modelling-risk-adjusted-variation-in-length-of-stay-among-australian-and-new-zealand-icus
#13
Lahn D Straney, Andrew A Udy, Aidan Burrell, Christoph Bergmeir, Sue Huckson, D James Cooper, David V Pilcher
PURPOSE: Comparisons between institutions of intensive care unit (ICU) length of stay (LOS) are significantly confounded by individual patient characteristics, and currently there is a paucity of methods available to calculate risk-adjusted metrics. METHODS: We extracted de-identified data from the Australian and New Zealand Intensive Care Society (ANZICS) Adult Patient Database for admissions between January 1 2011 and December 31 2015. We used a mixed-effects log-normal regression model to predict LOS using patient and admission characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28459929/behavioral-approach-to-appropriate-antimicrobial-prescribing-in-hospitals-the-dutch-unique-method-for-antimicrobial-stewardship-dumas-participatory-intervention-study
#14
Jonne J Sikkens, Michiel A van Agtmael, Edgar J G Peters, Kamilla D Lettinga, Martijn van der Kuip, Christina M J E Vandenbroucke-Grauls, Cordula Wagner, Mark H H Kramer
Importance: Inappropriate antimicrobial prescribing leads to antimicrobial resistance and suboptimal clinical outcomes. Changing antimicrobial prescribing is a complex behavioral process that is not often taken into account in antimicrobial stewardship programs. Objective: To examine whether an antimicrobial stewardship approach grounded in behavioral theory and focusing on preserving prescriber autonomy and participation is effective in improving appropriateness of antimicrobial prescribing in hospitals...
May 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28387195/orthopedic-surgeons-knowledge-regarding-risk-of-radiation-exposition-a-survey-analysis
#15
Nejat Tunçer, Ersin Kuyucu, Şafak Sayar, Gökhan Polat, İrem Erdil, İbrahim Tuncay
INTRODUCTION: The purpose of this study is to evaluate the knowledge levels of orthopedic surgeons working in Turkey about the uses and possible risks of fluoroscopy and assess methods for preventing radiation damage. METHODS: A questionnaire with a total of 12 questions was sent to 1121 orthopedic surgeons working in Turkey. The questionnaire evaluated participants' knowledge about the uses and risks of fluoroscopy and methods for preventing damage. One thousand and twenty-four orthopedic surgeons were found to be suitable for inclusion in the study...
2017: SICOT-J
https://www.readbyqxmd.com/read/28367525/the-distribution-of-orbscan-indices-in-young-population
#16
Hassan Hashemi, Mehdi Khabazkhoob, Negareh Yazdani, Hadi Ostadimoghaddam, Payam Nabovati, Raheleh Moravej, AbbasAli Yekta
PURPOSE: To determine the distribution of anterior eye biometry indices, such as keratometry pachymetry, anterior chamber depth (ACD), pupil diameter, and corneal diameter, as measured by Orbscan instrument in a young Iranian population. METHODS: A cross-sectional study was conducted, and subjects were selected through multistage cluster sampling from the students of Mashhad University of Medical Sciences. Objective and subjective refraction were performed followed by Orbscan imaging...
March 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28366342/pharmacokinetics-of-rotigotine-transdermal-system-in-adolescents-with-idiopathic-restless-legs-syndrome-willis-ekbom-disease
#17
Jan-Peer Elshoff, John Hudson, Daniel L Picchietti, Keith Ridel, Arthur S Walters, Kimberly Doggett, Kimberly Moran, Marga Oortgiesen, Francisco Ramirez, Erwin Schollmayer
OBJECTIVE: To investigate the pharmacokinetics (PK) of rotigotine transdermal system in adolescents with moderate-to-severe idiopathic restless legs syndrome (RLS). METHODS: This multicenter, open-label, dose-escalation study enrolled patients ≥13 to <18 years of age. Rotigotine transdermal patches were applied daily and up-titrated weekly: 0.5, 1, 2, 3 mg/24 h. Blood samples were collected on the final day of each dose step. Primary PK variables were the apparent total body clearance (CL/f; L/h) and volume of distribution at steady state (VSS/f; L) of unconjugated rotigotine for each dose step, calculated for the PK per-protocol set (PKPPS)...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28328718/validity-of-daily-and-weekly-self-reported-training-load-measures-in-adolescent-athletes
#18
Padraic J Phibbs, Gregory Roe, Ben Jones, Dale B Read, Jonathon Weakley, Joshua Darrall-Jones, Kevin Till
Phibbs, PJ, Roe, G, Jones, B, Read, DB, Weakley, J, Darrall-Jones, J, and Till, K. Validity of daily and weekly self-reported training load measures in adolescent athletes. J Strength Cond Res 31(4): 1121-1126, 2017-The primary aim of the study was to assess the level of agreement between the criterion session rating of perceived exertion (sRPE30min) and a practical measure of a self-reported Web-based training load questionnaire 24 hours after training (sRPE24h) in adolescent athletes. The secondary aim was to assess the agreement between weekly summated sRPE24h values (∑sRPE24h) and a weekly Web-based training diary (sRPEweekly) for all field-based training accumulated on a subsequent training week...
April 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28282851/twenty-four-hour-real-time-continuous-monitoring-of-cerebral-edema-in-rabbits-based-on-a-noninvasive-and-noncontact-system-of-magnetic-induction
#19
Gen Li, Ke Ma, Jian Sun, Gui Jin, Mingxin Qin, Hua Feng
Cerebral edema is a common disease, secondary to craniocerebral injury, and real-time continuous monitoring of cerebral edema is crucial for treating patients after traumatic brain injury. This work established a noninvasive and noncontact system by monitoring the magnetic induction phase shift (MIPS) which is associated with brain tissue conductivity. Sixteen rabbits (experimental group n = 10, control group, n = 6) were used to perform a 24 h MIPS and intracranial pressure (ICP) simultaneously monitored experimental study...
March 8, 2017: Sensors
https://www.readbyqxmd.com/read/28271424/a-randomized-controlled-multisite-study-of-behavioral-interventions-for-veterans-with-mental-illness-and-antipsychotic-medication-associated-obesity
#20
Zachary D Erickson, Crystal L Kwan, Hollie A Gelberg, Irina Y Arnold, Valery Chamberlin, Jennifer A Rosen, Chandresh Shah, Charles T Nguyen, Gerhard Hellemann, Dixie R Aragaki, Charles F Kunkel, Melissa M Lewis, Neena Sachinvala, Patrick A Sonza, Joseph M Pierre, Donna Ames
BACKGROUND: Weight gain and other metabolic sequelae of antipsychotic medications can lead to medication non-adherence, reduced quality of life, increased costs, and premature mortality. Of the approaches to address this, behavioral interventions are less invasive, cost less, and can result in sustained long-term benefits. OBJECTIVE: We investigated behavioral weight management interventions for veterans with mental illness across four medical centers within the Veterans Affairs (VA) Healthcare System...
April 2017: Journal of General Internal Medicine
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