keyword
MENU ▼
Read by QxMD icon Read
search

1120

keyword
https://www.readbyqxmd.com/read/29451143/familial-nonmedullary-thyroid-carcinoma-a-retrospective-analysis-of-117-families
#1
Ya-Bing Zhang, Xiao-Xin Wang, Xi-Wei Zhang, Zheng-Jiang Li, Jie Liu, Zhen-Gang Xu, Ping-Zhang Tang
Background: The first and most important step in characterizing familial nonmedullary thyroid carcinoma (NMTC) is to distinguish the true familial patients, which is the prerequisite for all accurate analyses. This study aimed to investigate whether patients from families with ≥3 first-degree relatives affected with NMTC have different characteristics than patients from families with only two affected members, and to compare these patients with those with sporadic disease. Methods: We analyzed the clinicopathological features and prognosis of 209 familial and 1120 sporadic cases of NMTC...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29423211/depressive-affect-in-incident-hemodialysis-patients
#2
Kathryn A McDougall, John W Larkin, Rebecca L Wingard, Yue Jiao, Sophia Rosen, Lin Ma, Len A Usvyat, Franklin W Maddux
Background: The prevalence of depressive affect is not well defined in the incident hemodialysis (HD) population. We investigated the prevalence of and associated risk factors and hospitalization rates for depressive affect in incident HD patients. Methods: We performed a prospective investigation using the Patient Health Questionnaire 2 (PHQ2) depressive affect assessment. From January to July of 2013 at 108 in-center clinics randomly selected across tertiles of baseline quality measures, we contacted 577 and 543 patients by telephone for depressive affect screening...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29406563/spectrum-of-apc-and-mutyh-germ-line-mutations-in-russian-patients-with-colorectal-malignancies
#3
G A Yanus, T A Akhapkina, A O Ivantsov, E V Preobrazhenskaya, S N Aleksakhina, I V Bizin, A P Sokolenko, N V Mitiushkina, E S Kuligina, E N Suspitsin, A R Venina, M M Holmatov, O A Zaitseva, O S Yatsuk, D V Pashkov, A M Belyaev, A V Togo, E N Imyanitov, A G Iyevleva
Distribution of cancer-predisposing mutations demonstrates significant interethnic variations. This study aimed to evaluate patterns of APC and MUTYH germ-line mutations in Russian patients with colorectal malignancies. APC gene defects were identified in 26/38 (68%) subjects with colon polyposis; 8/26 (31%) APC mutations were associated with two known mutational hotspots (p.E1309Dfs*4 (n = 5) and p.Q1062fs* (n = 3)), while 6/26 (23%) mutations were novel (p.K73Nfs*6, p.S254Hfs*12, p.S1072Kfs*9, p.E1547Kfs*11, p...
February 6, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29401610/an-image-based-small-molecule-screen-identifies-vimentin-as-a-pharmacologically-relevant-target-of-simvastatin-in-cancer-cells
#4
Kathryn P Trogden, Rachel A Battaglia, Parijat Kabiraj, Victoria J Madden, Harald Herrmann, Natasha T Snider
Vimentin is a cytoskeletal intermediate filament protein that is expressed in mesenchymal cells and cancer cells during the epithelial-mesenchymal transition. The goal of this study was to identify vimentin-targeting small molecules by using the Tocriscreen library of 1120 biochemically active compounds. We monitored vimentin filament reorganization and bundling in adrenal carcinoma SW13 vimentin-positive (SW13-vim+) cells via indirect immunofluorescence. The screen identified 18 pharmacologically diverse hits that included 2 statins-simvastatin and mevastatin...
January 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29400618/the-longitudinal-relationship-between-generalized-self-efficacy-and-physical-activity-in-school-aged-children
#5
Yao-Chuen Li, Divya Joshi, Sara King-Dowling, John Hay, Brent E Faught, John Cairney
Our understanding of the longitudinal relationship between generalized self-efficacy (GSE) and physical activity in children and youth is limited. The purpose of this study was to investigate the effect of GSE towards physical activity on sedentary behaviours and physical activity in school-aged children over time. A total of 2278 nine-year-old children (1120 girls and 1158 boys) were recruited at baseline and followed for seven waves of data collection from 2005 to 2008. All children completed questionnaires at each wave assessing their GSE (adequacy, predilection, and enjoyment), sedentary behaviours, free play, and organized activity...
February 5, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29390730/paradigmatic-variation-of-vowels-in-expressive-speech-acoustic-description-and-dimensional-analysis
#6
Albert Rilliard, Christophe d'Alessandro, Marc Evrard
Acoustic variation in expressive speech at the syllable level is studied. As emotions or attitudes can be conveyed by short spoken words, analysis of paradigmatic variations in vowels is an important issue to characterize the expressive content of such speech segments. The corpus contains 160 sentences produced under seven expressive conditions (Neutral, Anger, Fear, Surprise, Sensuality, Joy, Sadness) acted by a French female speaker (a total of 1120 sentences, 13 140 vowels). Eleven base acoustic parameters are selected for voice source and vocal tract related feature analysis...
January 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29369894/is-the-appropriate-use-criteria-for-type-ii-supracondylar-humerus-fractures-really-appropriate
#7
Mauricio Silva, Erin M Delfosse, Howard Park, Hemali Panchal, Edward Ebramzadeh
INTRODUCTION: The Appropriate Use Criteria for the treatment of supracondylar humerus fractures (SCHFs), developed by American Academy of Orthopaedic Surgeons, recommends pinning for all type II SCHFs. However, previous studies have suggested that, with close follow-up some of the less severe type II SCHF's can be successfully treated without surgery. Our purpose was to analyze data collected prospectively on a large cohort of type II SCHF's. METHODS: We reviewed clinical and radiographic information on all type II pediatric SCHF (n=1120) that were enrolled in a prospective registry and were followed for a minimum of 8 weeks...
January 24, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29352654/resistance-training-during-a-12-week-protein-supplemented-vlcd-treatment-enhances-weight-loss-outcomes-in-obese-patients
#8
Edward Jo, Phillip R Worts, Marcus L Elam, Ann Frost Brown, Andy V Khamoui, Do-Houn Kim, Ming-Chia Yeh, Michael J Ormsbee, Carla M Prado, Angelina Cain, Katie Snyder, Jeong-Su Kim
BACKGROUND: This investigation evaluated the efficacy by which resistance training enhances body composition, metabolic, and functional outcomes for obese patients undergoing a 12-week medically supervised hypocaloric treatment. METHODS: This was a single-blind, randomized, parallel-group prospective trial. Morbidly obese patients were prescribed a 12-week proprietary very low calorie diet (VLCD) treatment (Optifast®) with supplemental protein (1120 kcals/day) and were placed in one of two groups for 14 weeks: 1) Standard Treatment Control (CON) (n = 5) or 2) Resistance Training (RT) (n = 6)...
December 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29328267/25%C3%A2-%C3%A2-w-single-frequency-low-noise-fiber-mopa-at-1120%C3%A2-%C3%A2-nm
#9
Benoît Gouhier, Germain Guiraud, Sergio Rota-Rodrigo, Jian Zhao, Nicholas Traynor, Giorgio Santarelli
This Letter reports on the development of a 25 W single-frequency, all-fiber master oscillator power amplifier (MOPA) operating at 1120 nm. By heating the gain fiber at 75°C, an output power of 25.3 W is achieved with an optical-to-optical efficiency of 53.5%. The output shows no sign of stimulated Brillouin scattering and the signal to amplified spontaneous emission ratio is close to 40 dB. A M2 value of 1.15 and a polarization extinction ratio of 17 dB are measured. The relative intensity noise of the output is also characterized, reaching -155  dBc/Hz at 10 MHz at the maximum output power...
January 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29300410/a-critical-assessment-of-the-environmental-fate-of-linear-and-cyclic-volatile-methylsiloxanes-using-multimedia-fugacity-models
#10
Dimitri Panagopoulos, Matthew MacLeod
We apply multimedia models to systematically evaluate the fate profile of cyclic volatile methyl siloxanes (VMS) D4, D5 and D6, and the linear VMS L4 and L5 using recently reported measurements of their partition ratios between organic carbon and water (KOC), their salting out constants (Ks), and their enthalpy of sorption to organic carbon (ΔHOC). Our assessment follows a multi-stage strategy where the environmental fate of the chemicals is explored in generic regional models with increasing fidelity to the real system and in a region-specific model...
January 4, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29224257/models-of-care-for-non-invasive-ventilation-in-the-acute-copd-comparison-of-three-tertiary-hospitals-act3-study
#11
Kerry Parker, Vara Perikala, Ali Aminazad, Zheng Deng, Brigitte Borg, Catherine Buchan, Jo Toghill, Louis B Irving, Jeremy Goldin, David Charlesworth, Ajay Mahal, Suhith Illesinghe, Matthew T Naughton, Alan Young
BACKGROUND AND OBJECTIVE: Non-invasive ventilation (NIV) improves clinical outcomes in hypercapnic acute exacerbations of COPD (AECOPD), but the optimal model of care remains unknown. METHODS: We conducted a prospective observational non-inferiority study comparing three models of NIV care: general ward (Ward) (1:4 nurse to patient ratio, thrice weekly consultant ward round), a high dependency unit (HDU) (1:2 ratio, twice daily ward round) and an intensive care unit (ICU) (1:1 ratio, twice daily ward round) model in three similar teaching tertiary hospitals...
December 10, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29210393/a-high-performance-electrochemical-supercapacitor-based-on-a-polyaniline-reduced-graphene-oxide-electrode-and-a-copper-ii-ion-active-electrolyte
#12
Yangxi Luo, Qin'e Zhang, Wenjing Hong, Zongyuan Xiao, Hua Bai
Active electrolyte enhanced supercapacitors (AEESCs) have received increasing attention because of their large specific capacitance and easy fabrication process. The better matching between the active electrolyte and the counter electrode and the slow self-discharge rate are the challenges of this type of supercapacitor. In this paper, a novel AEESC with polyaniline/reduced graphene oxide hydrogel (PANI/RGOHG) as the anode and Cu(ii) ions as the cathodic active electrolyte is constructed. Experimental results demonstrate that the electrode potentials of PANI and Cu(ii) can match perfectly, thus the device has a wide working voltage range...
December 6, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29203914/synthetically-lethal-nanoparticles-for-treatment-of-endometrial-cancer
#13
Kareem Ebeid, Xiangbing Meng, Kristina W Thiel, Anh-Vu Do, Sean M Geary, Angie S Morris, Erica L Pham, Amaraporn Wongrakpanich, Yashpal S Chhonker, Daryl J Murry, Kimberly K Leslie, Aliasger K Salem
Uterine serous carcinoma, one of the most aggressive types of endometrial cancer, is characterized by poor outcomes and mutations in the tumour suppressor p53. Our objective was to engender synthetic lethality to paclitaxel (PTX), the frontline treatment for endometrial cancer, in tumours with mutant p53 and enhance the therapeutic efficacy using polymeric nanoparticles (NPs). First, we identified the optimal NP formulation through comprehensive analyses of release profiles and cellular-uptake and cell viability studies...
December 4, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/29203011/automated-recognition-of-rear-seat-occupants-head-position-using-kinect%C3%A2-3d-point-cloud
#14
Helen Loeb, Jinyong Kim, Kristy Arbogast, Jonny Kuo, Sjaan Koppel, Suzanne Cross, Judith Charlton
INTRODUCTION: Child occupant safety in motor-vehicle crashes is evaluated using Anthropomorphic Test Devices (ATD) seated in optimal positions. However, child occupants often assume suboptimal positions during real-world driving trips. Head impact to the seat back has been identified as one important injury causation scenario for seat belt restrained, head-injured children (Bohman et al., 2011). There is therefore a need to understand the interaction of children with the Child Restraint System to optimize protection...
December 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/29194117/nonsmall-cell-lung-cancer-from-hiv-infected-patients-expressed-programmed-cell-death-ligand-1-with-marked-inflammatory-infiltrates
#15
Charlotte Domblides, Martine Antoine, Cécile Hamard, Nathalie Rabbe, Anita Rodenas, Thibault Vieira, Perrine Crequit, Jacques Cadranel, Armelle Lavolé, Marie Wislez
OBJECTIVE: Immunotherapies targeting the programmed cell death-1 (PD-1)/PD-ligand 1 (PD-L1) checkpoint improved prognosis in lung cancer. PD-1/PD-L1 status, however, has not been investigated in human immunodeficiency virus (HIV)-positive patients. This study assessed PD-L1 status and tumor immune-cell infiltration in nonsmall cell lung cancer (NSCLC) in HIV patients. METHODS: Consecutive HIV patients treated between 1996 and 2014 were enrolled. PD-L1 tumor expression was assessed using immunohistochemistry with two antibodies (clones 5H1 and E1L3N), and tumor immune-cell infiltration with CD3, CD4, CD8, CD20, CD163, and MPO...
February 20, 2018: AIDS
https://www.readbyqxmd.com/read/29172901/correction-to-j-med-food-2017-20-1113-1120-doi-10-1089-jmf-2017-3951
#16
(no author information available yet)
No abstract text is available yet for this article.
November 27, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29161936/a-morphological-and-quantitative-analysis-of-lung-ct-scan-in-patients-with-acute-respiratory-distress-syndrome-and-in-cardiogenic-pulmonary-edema
#17
Giordano Vergani, Massimo Cressoni, Francesco Crimella, Camilla L'Acqua, Erminio Sisillo, Martina Gurgitano, Alessandro Liguori, Andrea Annoni, Gianpaolo Carrafiello, Davide Chiumello
BACKGROUND: The acute respiratory distress syndrome (ARDS) and cardiogenic pulmonary edema (CPE) are both characterized by an increase in lung edema that can be measured by computed tomography (CT). The aim of this study was to compare possible differences between patients with ARDS and CPE in the morphologic pattern, the aeration, and the amount and distribution of edema within the lung. METHODS: Lung CT was performed at a mean positive end-expiratory pressure level of 5 cm H2O in both groups...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29156654/a-dual-band-frequency-reconfigurable-origami-magic-cube-antenna-for-wireless-sensor-network-applications
#18
Syed Imran Hussain Shah, Sungjoon Lim
In this paper, a novel dual band frequency reconfigurable antenna using an origami magic cube is proposed for wireless sensor network (WSN) applications. The proposed origami antenna consists of a meandered monopole folded onto three sides of the magic cube. A microstrip open-ended stub is loaded on the meandered monopole. The proposed origami magic cube can be mechanically folded and unfolded. The proposed antenna operates at 1.57 GHZ and 2.4 GHz in the folded state. In the unfolded state, the proposed antenna operates at 900 MHz and 2...
November 20, 2017: Sensors
https://www.readbyqxmd.com/read/29140520/therapeutic-target-database-update-2018-enriched-resource-for-facilitating-bench-to-clinic-research-of-targeted-therapeutics
#19
Ying Hong Li, Chun Yan Yu, Xiao Xu Li, Peng Zhang, Jing Tang, Qingxia Yang, Tingting Fu, Xiaoyu Zhang, Xuejiao Cui, Gao Tu, Yang Zhang, Shuang Li, Fengyuan Yang, Qiu Sun, Chu Qin, Xian Zeng, Zhe Chen, Yu Zong Chen, Feng Zhu
Extensive efforts have been directed at the discovery, investigation and clinical monitoring of targeted therapeutics. These efforts may be facilitated by the convenient access of the genetic, proteomic, interactive and other aspects of the therapeutic targets. Here, we describe an update of the Therapeutic target database (TTD) previously featured in NAR. This update includes: (i) 2000 drug resistance mutations in 83 targets and 104 target/drug regulatory genes, which are resistant to 228 drugs targeting 63 diseases (49 targets of 61 drugs with patient prevalence data); (ii) differential expression profiles of 758 targets in the disease-relevant drug-targeted tissue of 12 615 patients of 70 diseases; (iii) expression profiles of 629 targets in the non-targeted tissues of 2565 healthy individuals; (iv) 1008 target combinations of 1764 drugs and the 1604 target combination of 664 multi-target drugs; (v) additional 48 successful, 398 clinical trial and 21 research targets, 473 approved, 812 clinical trial and 1120 experimental drugs, and (vi) ICD-10-CM and ICD-9-CM codes for additional 482 targets and 262 drugs against 98 disease conditions...
November 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29137901/impact-of-femoral-stem-design-on-failure-after-anterior-approach-total-hip-arthroplasty
#20
Krishna R Cidambi, Steven L Barnett, Paige R Mallette, Jay J Patel, Nader A Nassif, Robert S Gorab
BACKGROUND: An increased rate of complications related to femoral component failure has been described with less invasive total hip arthroplasty (THA). This study evaluated the incidence of femoral complications associated with the direct anterior approach for THA. METHODS: Retrospective review was performed of the initial 1120 consecutive patients who underwent direct anterior THA by 2 surgeons. RESULTS: A total of 899 patients (80.3%) had a 2-year follow-up (range, 2-8 years)...
November 11, 2017: Journal of Arthroplasty
keyword
keyword
92785
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"