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Winnie A Okeyo, Norah P Saarman, Michael Mengual, Kirstin Dion, Rosemary Bateta, Paul O Mireji, Sylvance Okoth, Johnson O Ouma, Collins Ouma, Joel Ochieng, Grace Murilla, Serap Aksoy, Adalgisa Caccone
BACKGROUND: Glossina pallidipes is a major vector of both Human and Animal African Trypanosomiasis (HAT and AAT) in Kenya. The disease imposes economic burden on endemic regions in Kenya, including south-western Kenya, which has undergone intense but unsuccessful tsetse fly control measures. We genotyped 387 G. pallidipes flies at 13 microsatellite markers to evaluate levels of temporal genetic variation in two regions that have been subjected to intensive eradication campaigns from the 1960s to the 1980s...
October 10, 2017: Parasites & Vectors
Teresa Vanessa Fiorentino, Maria Adelaide Marini, Elena Succurro, Francesco Andreozzi, Angela Sciacqua, Marta Letizia Hribal, Francesco Perticone, Giorgio Sesti
AIMS: Hemoglobin glycation index (HGI), which is the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose levels, represents a measure of the degree of non-enzymatic glycation of hemoglobin and it has been found to be positively associated with diabetic complications. Herein we investigated whether HGI is associated with hepatic steatosis and related biomarkers in subjects without diabetes. METHODS: 1120 White individuals without diabetes were stratified in quartiles according to HGI levels...
October 6, 2017: Diabetes Research and Clinical Practice
Ellen Nogueira Pangrazi, Raquel Frenedoso da Silva, Larissa Akemi Kido, Fabio Montico, Valéria Helena Alves Cagnon
Prostate cancer progression mechanism has been linked to epithelial proliferation, tumor invasion ability and growth factors. Nintedanib (BIBF 1120) has been reported as being FGF and VEGF pathway inhibitors, exhibiting antitumor activity. Thus, the objective herein was to characterize the early Nintedanib treatment effects on the structure and molecules involved in the basal membrane, the extracellular matrix maintenance, in addition to the angiogenesis and mitogenic processes at different grades of prostatic tumor development in TRAMP mice...
October 5, 2017: Cell Biology International
Chanaka Nadeeshan Kahathuduwa, Tyler Davis, Michael O'Boyle, Lori Ann Boyd, Shao-Hua Chin, Dmitrii Paniukov, Martin Binks
OBJECTIVES: Calorie restriction via total meal replacement (TMR) results in greater reduction of food cravings compared to reduced-calorie typical diet (TD). Direct evidence of the impact of these interventions on human brain fMRI food-cue reactivity (fMRI-FCR) and functional connectivity is absent. We examined the effects of a 3-week 1120 kcal/d TMR intervention as compared to an iso-caloric TD intervention using an fMRI-FCR paradigm. METHODS: Thirty-two male and female subjects with obesity (19-60 years; 30-39...
September 25, 2017: Appetite
Sébastien Loranger, Vladimir Karpov, Gregory W Schinn, Raman Kashyap
Distributed feedback (DFB) fiber lasers have been demonstrated to be excellent narrow-linewidth (kilohertz range) single-frequency laser sources. However, this type of laser is normally limited to rare-earth-doped fibers. Raman gain offers an alternative, operating at any arbitrary wavelength. We demonstrate here linearly polarized, single-frequency, DFB fiber Bragg grating Raman lasers with, to the best of our knowledge, the lowest pump threshold of 350 mW, an output power of up to 50 mW at 1120 nm, an 8.5% slope efficiency, and 300 mW of output power at 1178 nm...
October 1, 2017: Optics Letters
Hanwei Zhang, Long Huang, Pu Zhou, Xiaolin Wang, Jiangming Xu, Xiaojun Xu
We report on the demonstration of a high power, high beam quality random fiber laser. It is a half-open cavity based on 130-m-long large mode area step-index fiber with a core diameter of 20 μm and a numerical aperture of 0.08. The random laser cavity, whose central wavelength is 1120 nm, is pumped by a 1070 nm Yb-doped fiber oscillator. The maximum output power is 418 W with respect to the injected pump power of 588 W, corresponding to the optical-to-optical efficiency of 71%. The output power, spectral, and temporal characteristics are carefully presented and discussed, showing that such a cavity can export high power random laser stably and effectively...
September 1, 2017: Optics Letters
Paul J Jones, Blake Riser, Jingsong Zhang
Thermal decomposition of t-butyl hydroperoxide and di-t-butyl peroxide was investigated using flash pyrolysis (in a short reaction time of <100 μs) and vacuum-ultraviolet (λ = 118.2 nm) single-photon ionization time-of-flight mass spectrometry (VUV-SPI-TOFMS) at temperatures up to 1120 K and quantum computational methods. Acetone and methyl radical were detected as the predominant products in the initial decomposition of di-t-butyl peroxide via O-O bond fission. In the initial dissociation of t-butyl hydroperoxide, acetone, methyl radical, isobutylene, and isobutylene oxide products were identified...
October 10, 2017: Journal of Physical Chemistry. A
Ayca Yilmaz, Isil Karagoz-Kucukay
PURPOSE: To evaluate the efficacy of different obturation techniques in root canals instrumented either by hand or rotary instruments with regard to the percentage of gutta- percha-filled area (PGFA). MATERIALS AND METHODS: One hundred and sixty extracted mandibular premolars with single, straight root canals were studied. Root canals were prepared to an apical size of 30 by hand with a modified crown-down technique or the ProTaper and HEROShaper systems. Teeth were divided into eight groups (n=20) according to the following instrumentation and obturation techniques: G1: Hand files+lateral condensation (LC), G2: Hand files+Thermafil, G3: ProTaper+LC, G4: ProTaper+single-cone, G5: ProTaper+ProTaper-Obturator, G6: HEROShaper+LC, G7: HEROShaper+single-cone, G8: HEROShaper+HEROfill...
2017: J Istanb Univ Fac Dent
Stephen A Mears, Kathryn Dickinson, Kurt Bergin-Taylor, Reagan Dee, Jack Kay, Lewis J James
PURPOSE: To examine the effect on short duration, high intensity cycling time trial performance when a semi-solid breakfast containing carbohydrate or a taste and texture matched placebo is ingested 90 minutes pre-exercise compared to a water control. METHODS: Thirteen well trained cyclists (25 ± 8 years, 71.1 ± 5.9 kg, 1.76 ± 0.04 m, 383 ± 46 Wmax, VO2peak 4.42 ± 0.53 L·min(-1)) performed three experimental trials examining breakfast ingestion 90 minutes before a 10 minute steady state cycle (60% Wmax) and a ~20 minute time trial (to complete a workload target of 376 ± 36 kJ)...
September 27, 2017: International Journal of Sports Physiology and Performance
M V Epifanova, M E Chalyi, A O Krasnov
AIM: To determine the quantitative and qualitative composition of growth factors (PDGF-AA, PDGF-BB, VEGF, VEGF-D, FGF-acid, FGF-basic) and platelets in various modifications of APRP. MATERIALS AND METHODS: Blood of 12 male volunteers (control group) and 12 patients with ED was used to prepare APRP and the subsequently determine the concentration of growth factors. The growth factor concentrations (FGF acid, FGF basic, PDGF-AA, PDGF-BB, VEGF, VEGF-D) was determined using a flow cytometry-based xMAP Luminex (Gen-Probe) system...
September 2017: Urologii︠a︡
Shih-Pin Chen, Jong-Ling Fuh, Ming-Yi Chung, Ying-Chao Lin, Yi-Chu Liao, Yen-Feng Wang, Chia-Lin Hsu, Ueng-Cheng Yang, Ming-Wei Lin, Jen-Jie Chiou, Po-Jen Wang, Ping-Kun Chen, Pi-Chuan Fan, Jer-Yuan Wu, Yuan-Tsong Chen, Lung-Sen Kao, Cathy Shen-Jang Fann, Shuu-Jiun Wang
Background Susceptibility genes for migraine, despite it being a highly prevalent and disabling neurological disorder, have not been analyzed in Asians by genome-wide association study (GWAS). Methods We conducted a two-stage case-control GWAS to identify susceptibility genes for migraine without aura in Han Chinese residing in Taiwan. In the discovery stage, we genotyped 1005 clinic-based Taiwanese migraine patients and 1053 population-based sex-matched controls using Axiom Genome-Wide CHB Array. In the replication stage, we genotyped 27 single-nucleotide polymorphisms with p < 10(-4) in 1120 clinic-based migraine patients and 604 sex-matched normal controls by using Sequenom...
January 1, 2017: Cephalalgia: An International Journal of Headache
Jens Fichtner, Nicole Hofmann, Anna Rienmüller, Niels Buchmann, Jens Gempt, Jan S Kirschke, Florian Ringel, Bernhard Meyer, Yu-Mi Ryang
BACKGROUND: Recent studies could show higher accuracy rates of image-guided pedicle screw placement compared to freehand placement. However, data focusing on the impact of spinal navigation on the rate of revision surgeries due to misplaced pedicle screws (PS) are scarce. OBJECTIVE: This study is aimed at identifying the rate of revision surgeries for misplaced PS comparing 3D fluoroscopic navigation (3DFL) to freehand (FH) PS placement. METHODS: A retrospective analysis of a total of 2232 patients (mean age 65...
September 22, 2017: World Neurosurgery
Javier Angeles-Martínez, Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, José Manuel Fragoso, Eyerahi Bravo-Flores, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
Interleukin IL-15 (IL-15) has been implicated in the development of coronary artery disease (CAD). The aim of the present study was to evaluate the role of IL-15 gene polymorphisms as susceptibility markers for development of subclinical atherosclerosis (SA) and cardiovascular risk factors in Mexican population. Four IL-15 gene polymorphisms (rs4956403, rs3806798, rs1057972 and rs10833) were analyzed in a group of 397 individuals with SA and 1120 controls. Under different inheritance models adjusted by traditional risk factors, the rs10833T allele was associated with increased risk of developing SA [OR=1...
September 15, 2017: Cytokine
(no author information available yet)
Gene identification in epilepsy has mainly been limited to large families segregating genes of major effect and de novo mutations in epileptic encephalopathies. Many families that present with common non-acquired focal epilepsies and genetic generalized epilepsies remain unexplained. We assembled a cohort of 'genetically enriched' common epilepsies by collecting and phenotyping families containing multiple individuals with unprovoked seizures. We aimed to determine if specific clinical epilepsy features aggregate within families, and whether this segregation of phenotypes may constitute distinct 'familial syndromes' that could inform genomic analyses...
August 1, 2017: Brain: a Journal of Neurology
Cornelia Laule, Thorarin A Bjarnason, Irene M Vavasour, Anthony L Traboulsee, G R Wayne Moore, David K B Li, Alex L MacKay
Prolonged spin-spin relaxation times in tumour tissue have been observed since some of the earliest nuclear magnetic resonance investigations of the brain. Over the last three decades, numerous studies have sought to characterize tumour morphology and malignancy using quantitative assessment of T 2 relaxation times, although attempts to categorize and differentiate tumours have had limited success. However, previous work must be interpreted with caution as relaxation data were typically acquired using a variety of multiple echo sequences with a range of echoes and T 2 decay curves and were frequently fit with monoexponential analysis...
September 11, 2017: Journal of Neurology
Se Yeon Choi, Byoung Geol Choi, Seung-Woon Rha, Jae Kyeong Byun, Min Suk Shim, Hu Li, Ahmed Mashaly, Cheol Ung Choi, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Myung Ho Jeong
BACKGROUND: Diabetes Mellitus (DM) is an important factor of adverse cardiovascular events in acute ST-segment elevation myocardial infarction (STEMI) patients. Renin-angiotensin-aldosterone system (RAAS) inhibitors is associated with improved clinical outcomes, however, there are limited data comparing the effectiveness of two different RAAS inhibitors in STEMI patients with DM undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). METHODS: A total of 3811 eligible STEMI patients with DM were enrolled in Korea Acute Myocardial Infarction Registry (KAMIR)...
August 12, 2017: International Journal of Cardiology
I Bizjak, C Fiala, L Berggren, H Hognert, I Sääv, J Bring, K Gemzell-Danielsson
OBJECTIVE: To assess the efficacy and safety of medical termination of pregnancy (MTOP) when no intrauterine pregnancy (IUP) is confirmed on ultrasound. DESIGN: Retrospective case-note review. SETTING: Two gynaecological clinics in Vienna, Austria, and Gothenburg, Sweden. POPULATION: All women with gestations of ≤49 days undergoing an MTOP during 2004-14 (Vienna) and 2012-15 (Gothenburg). METHODS: Two study cohorts were created: women with and women without a confirmed IUP...
August 30, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
Khalida Itriyeva, Ronald Feinstein, Linda Carmine
Background Concussions, a form of mild traumatic brain injury, are a current "hot topic" in sports and medicine, with current research focusing on diagnosis, treatment, and the long-term effects of repeated concussions on development of chronic traumatic encephalopathy. Concussions represent 8.9% of all high school athletic injuries, and pediatricians see many of these patients in their practices, however evolving guidelines and recommendations have resulted in varying practices among providers. Objective To assess how local pediatricians in New York Chapter 2 of the American Academy of Pediatrics (AAP) diagnose and treat concussion patients, and to evaluate the need for continuing education in this area...
August 25, 2017: International Journal of Adolescent Medicine and Health
Christopher G Fawsitt, Jane Bourke, Aileen Murphy, Brendan McElroy, Jennifer E Lutomski, Rosemary Murphy, Richard A Greene
BACKGROUND: The Irish government has committed to expand midwifery-led care alongside consultant-led care nationally, although very little is known about the potential net benefits of this reconfiguration. OBJECTIVES: To formally compare the costs and benefits of the major models of care in Ireland, with a view to informing priority setting using the contingent valuation technique and cost-benefit analysis. METHODS: A marginal payment scale willingness-to-pay question was adopted from an ex ante perspective...
August 21, 2017: Applied Health Economics and Health Policy
Guangxin Li, Chao Wang, Meichen Feng, Wude Yang, Fangzhou Li, Ruiyun Feng
The growth status of winter wheat in irrigated field and rainfed field are obviously different and the field types may have an effect on the predictive accuracy of hyperspectral model. The objectives of the present study were to understand the difference of spectral sensitive wavelengths for leaf area index (LAI) in two field types and realize its hyperspectral prediction. In study, a total of 31 and 28 sample sites in irrigated fields and rainfed fields respectively were selected from Wenxi County, and the LAI and canopy spectra were also collected at the main grow stage of winter wheat...
2017: PloS One
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