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https://www.readbyqxmd.com/read/28209612/microrna-520f-reverses-epithelial-to-mesenchymal-transition-by-targeting-adam9-and-tgfbr2
#1
Jasmijn Gm van Kampen, Onno van Hooij, Cornelius Fj Jansen, Frank P Smit, Paula I van Noort, Iman J Schultz, Roel Qj Schaapveld, Jack A Schalken, Gerald W Verhaegh
Reversing epithelial-to-mesenchymal transition (EMT) in cancer cells has been widely considered as an approach to combat cancer progression and therapeutic resistance, but a limited number of broadly comprehensive investigations of microRNAs involved in this process have been conducted. In this study, we screened a library of 1120 microRNA for their ability to transcriptionally activate the E-cadherin gene CDH1 in a promoter reporter assay as a measure of EMT reversal. By this approach, we defined miR-520f as a novel EMT-reversing microRNA...
February 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28202209/characteristics-and-prognosis-of-japanese-male-and-female-lung-cancer-patients-the-biobank-japan-project
#2
Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Makoto Hirata, Akiko Nagai, Zentaro Yamagata, Toshiharu Ninomiya, Kaori Muto, Yutaka Kiyohara, Koichi Matsuda, Yoichiro Kamatani, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi
BACKGROUND: In Japanese males and females, lung cancer is currently the second and fourth most common type of cancer, and the first and second leading cause of cancer-related deaths, respectively. METHODS: Of all Japanese male and female lung cancer patients aged ≥20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 764 males and 415 females were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry...
February 13, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28193045/contribution-of-ribonucleic-acid-rna-to-the-fourier-transform-infrared-ftir-spectrum-of-eukaryotic-cells
#3
Paolo Zucchiatti, Elisa Mitri, Saša Kenig, Fulvio Billè, George Kourousias, Diana Eva Bedolla, Lisa Vaccari
We report on an optimized protocol for the digestion of cellular RNA, which minimally affects the cell membrane integrity, maintaining substantially unaltered the vibrational contributions of the other cellular macromolecules. The design of this protocol allowed us to collect the first Fourier transform infrared (FTIR) spectra of intact hydrated B16 mouse melanoma cells deprived of RNA and to highlight the in-cell diagnostic spectral features of it. Complementing the cellular results with the FTIR analysis of extracted RNA, ds-DNA, ss-cDNA and isolated nuclei, we verified that the spectral component centered at ∼1220 cm(-1) is a good qualitative and semiquantitative marker of cellular DNA, since it is minimally affected by cellular RNA removal...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28187745/a-systematic-review-of-undisplaced-femoral-neck-fracture-treatments-for-patients-over-65%C3%A2-years-of-age-with-a-focus-on-union-rates-and-avascular-necrosis
#4
Dan-Feng Xu, Fang-Gang Bi, Chi-Yuan Ma, Zheng-Fa Wen, Xun-Zi Cai
BACKGROUND: It remains unclear whether conservative treatment should be used to treat the common undisplaced femoral neck fractures that develop in the elderly. Herein, we systematically review the rates of union and avascular necrosis after conservative and surgical treatment of undisplaced femoral neck fractures. METHODS: We searched the EMBASE, PubMed, OVID, Cochrane Library, Web of Science, and Scopus databases for randomized controlled trials or observational studies that assessed the outcomes of conservative or surgical treatments of undisplaced femoral neck fractures...
February 10, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28187633/integrative-taxonomy-reveals-the-first-record-and-a-new-species-for-the-previously-monotypic-genus-i-tethytimea-i-tethyida-tethyidae-in-the-gulf-of-mexico
#5
José Antonio Cruz-Barraza, Cristina Vega, Enrique Ávila, Laura Elena Vázquez-Maldonado
The first record of the previous monotypic genus Tethytimea and the description of a new species from cryptic habitats of Gulf of Mexico are presented. Tethytimea carmelita sp. nov., is a red orange cushion shaped sponge (about 5 mm thick) with a tuberculate to granular surface. The spicular complement is formed by tylostyles (200-1120 µm length), smooth spheres (12.5-55 µm in diameter); megasters-spheroxyasters (12.5-90 µm in diameter); and micrasters in two categories: oxy-strongylasters (12.5-27.5 µm in diameter) and spherotylasters (2...
January 25, 2017: Zootaxa
https://www.readbyqxmd.com/read/28173887/an-empirical-analysis-of-the-cost-of-rearing-dairy-heifers-from-birth-to-first-calving-and-the-time-taken-to-repay-these-costs
#6
A C Boulton, J Rushton, D C Wathes
Rearing quality dairy heifers is essential to maintain herds by replacing culled cows. Information on the key factors influencing the cost of rearing under different management systems is, however, limited and many farmers are unaware of their true costs. This study determined the cost of rearing heifers from birth to first calving in Great Britain including the cost of mortality, investigated the main factors influencing these costs across differing farming systems and estimated how long it took heifers to repay the cost of rearing on individual farms...
February 8, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28147598/multiple-scattering-in-random-dispersions-of-spherical-scatterers-effects-of-shear-acoustic-interactions
#7
Valerie J Pinfield, Derek Michael Forrester
The propagation of acoustic waves through a suspension of spherical particles in a viscous liquid is investigated, through application of a multiple scattering model. The model is based on the multiple scattering formulation of Luppé, Conoir, and Norris [J. Acoust. Soc. Am. 131, 1113-1120 (2012)] which incorporated the effects of thermal and shear wave modes on propagation of the acoustic wave mode. Here, the model is simplified for the case of solid particles in a liquid, in which shear waves make a significant contribution to the effective properties...
January 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28141621/high-incidence-and-prevalence-of-drug-related-movement-disorders-in-young-patients-with-psychotic-disorders
#8
Thierry Q Mentzel, Ritsaert Lieverse, Oswald Bloemen, Wolfgang Viechtbauer, Peter N van Harten
BACKGROUND: Drug-related movement disorders (DRMDs) reduce quality of life and contribute to medication noncompliance of patients with psychotic disorders. Little is known about the epidemiology of DRMDs in relatively young patients a few years after onset of psychosis. This is an important period to study, as the impact of the antipsychotic treatment on the long-term potentiation of the neural pathways associated with psychotic disorders and DRMDs is still minimal. This study investigated the prevalence, incidence, persistence, and clinical correlates of DRMDs in patients during their first years after disease onset...
January 30, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28114631/differences-in-clinical-activity-and-medicare-payments-for-female-vs-male-ophthalmologists
#9
Ashvini K Reddy, Gregory W Bounds, Sophie J Bakri, Lynn K Gordon, Justine R Smith, Julia A Haller, Audina M Berrocal, Jennifer E Thorne
Importance: The number of women in ophthalmology is rising. Little is known about their clinical activity and collections. Objective: To examine whether charges, as reflected in reimbursements from the Centers for Medicare & Medicaid Services (CMS) to ophthalmologists, differ by sex and how disparity relates to differences in clinical activity. Design, Setting, and Participants: Retrospective review of the CMS database for payments to ophthalmologists from January 1, 2012, through December 31, 2013...
January 19, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28112857/sensitive-detection-of-carcinoembryonic-antigen-using-stability-limited-few-layer-black-phosphorus-as-an-electron-donor-and-a-reservoir
#10
Jian Peng, Youqun Lai, Yuanyuan Chen, Jun Xu, Liping Sun, Jian Weng
The instability of few-layer black phosphorus (FL-BP) hampers its further applications. Here, it can be demonstrated that the instability of FL-BP can also be the advantage for application in biosensor. First, gold nanoparticle/FL-BP (BP-Au) hybrid is facilely synthesized by mixing Au precursor with FL-BP. BP-Au shows outstanding catalytic activity (K = 1120 s(-1) g(-1) ) and low activation energy (17.53 kJ mol(-1) ) for reducing 4-nitrophenol, which is attributed to the electron-reservoir and electron-donor properties of FL-BP, and synergistic interaction of Au nanoparticles and FL-BP...
January 23, 2017: Small
https://www.readbyqxmd.com/read/28059421/hierarchical-nitrogen-doped-porous-graphene-reduced-fluorographene-sulfur-hybrids-for-high-performance-lithium-sulfur-batteries
#11
Zhixuan Liu, Jie Li, Jingwei Xiang, Shuai Cheng, Hao Wu, Na Zhang, Lixia Yuan, Wenfeng Zhang, Jia Xie, Yunhui Huang, Haixin Chang
It is a great challenge to obtain high performance cathodes with a high sulfur loading and good cycle performance due to the dissolution of intermediate lithium polysulfides in lithium-sulfur batteries. Herein, we report a novel hierarchical hybrid composed of nitrogen-doped porous graphene (NG), reduced fluorographene or graphene fluoride (RFG), and sulfur as a composite cathode in the Li-S batteries. In comparison with sulfur composites based on only either nitrogen-doped porous graphene or pure reduced fluorographene, the hierarchical hybrid of RFG, NG, and sulfur (NG-RFG/S) shows a better reversible capacity and rate capability performance due to a better confinement effect of lithium polysulfides and sulfur...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28059364/1120-nm-khz-linewidth-single-polarization-single-frequency-yb-doped-phosphate-fiber-laser
#12
Changsheng Yang, Qilai Zhao, Zhouming Feng, Mingying Peng, Zhongmin Yang, Shanhui Xu
A spectrally clean kHz-linewidth single-polarization single-frequency distributed Bragg reflector Yb-doped phosphate fiber (YPF) laser at 1120 nm (> 1100 nm) for the first time is demonstrated. By enhancing the reflectivity of output fiber Bragg grating and optimizing the length of YPF to implement the effective ASE suppression and single-longitudinal-mode long-wavelength lasing, a stable output power of over 62 mW is achieved from a 31-mm-long highly YPF with a linewidth of 5.7 kHz. The signal to noise ratio of > 67 dB, the polarization extinction ratio of > 25 dB, and the relative intensity noise of < -150 dB/Hz for the frequencies above 10...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28054562/identification-of-a-drug-targeting-an-intrinsically-disordered-protein-involved-in-pancreatic-adenocarcinoma
#13
José L Neira, Jennifer Bintz, María Arruebo, Bruno Rizzuti, Thomas Bonacci, Sonia Vega, Angel Lanas, Adrián Velázquez-Campoy, Juan L Iovanna, Olga Abián
Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and regulatory functions. Often associated with human diseases, they constitute drug-development targets. NUPR1 is a multifunctional IDP, over-expressed and involved in pancreatic ductal adenocarcinoma (PDAC) development. By screening 1120 FDA-approved compounds, fifteen candidates were selected, and their interactions with NUPR1 were characterized by experimental and simulation techniques. The protein remained disordered upon binding to all fifteen candidates...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28045646/initial-experience-of-using-dual-energy-ct-with-an-iodine-overlay-image-for-hand-psoriatic-arthritis-comparison-study-with-contrast-enhanced-mr-imaging
#14
Takeshi Fukuda, Yoshinori Umezawa, Shinjiro Tojo, Takenori Yonenaga, Akihiko Asahina, Hidemi Nakagawa, Kunihiko Fukuda
Purpose To determine the feasibility of dual-energy (DE) computed tomography (CT) with an iodine overlay image (IOI) for evaluation of psoriatic arthritis in the hand. Materials and Methods Approval from the institutional ethics committee and written informed consent from all patients were obtained. This prospective study included 16 patients who had psoriasis with finger joint symptoms from January 2015 to January 2016. Contrast material-enhanced (CE) DE CT and 1.5-T CE magnetic resonance (MR) imaging were performed within 1 month of each other...
December 29, 2016: Radiology
https://www.readbyqxmd.com/read/28036026/simultaneous-determination-and-pharmacokinetic-study-of-six-components-in-rat-plasma-by-hplc-ms-ms-after-oral-administration-of-acanthopanax-sessiliflorus-fruit-extract
#15
Peng Du, Mingdao Lei, Yu Liu, Shilin Yang
A specific and reliable HPLC-MS/MS method was developed and validated for the simultaneous determination of protocatechuic acid (PCA), scopolin, (-)-pinoresinol-4,4'-di-O-β-d-glucopyranoside (PDG), acanthoside D, acanthoside B and hyperin in rat plasma for the first time. The analytes were separated on a C18 column (50 × 2.1 mm, 1.8 µm) and a triple-quadrupole mass spectrometer equipped with an electrospray ionization (ESI) source was used for detection. The rat plasma sample was prepared using the protein precipitation procedure...
December 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28027610/effects-of-low-intensity-pulsed-ultrasound-on-implant-osseointegration-in-ovariectomized-rats
#16
Hongbo Zhou, Yongfu Hou, Zhimin Zhu, Weixiong Xiao, Qian Xu, Lei Li, Xin Li, Wenchuan Chen
OBJECTIVES: To investigate the effect of low-intensity pulsed ultrasound (US) on peri-implant bone healing and osseointegration under osteoporotic conditions. METHODS: Seventy-two 12-week-old female Sprague Dawley rats received bilateral ovariectomies. Twelve weeks later, titanium implants were bilaterally placed in the proximal tibial metaphysis. The right tibia was exposed to low-intensity pulsed US (40 mW/cm(2) , spatial and temporal average) for 20 min/d starting the 2nd day after implantation, and the left tibia served as a control without stimulation...
April 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28026027/the-contemporary-value-of-peak-creatine-kinase-mb-after-st-segment-elevation-myocardial-infarction-above-other-clinical-and-angiographic-characteristics-in-predicting-infarct-size-left-ventricular-ejection-fraction-and-mortality
#17
Minke H T Hartman, Ruben N Eppinga, Pieter J J Vlaar, Chris P H Lexis, Erik Lipsic, Joost D E Haeck, Dirk J van Veldhuisen, Iwan C C van der Horst, Pim van der Harst
BACKGROUND: Complex multimarker approaches to predict outcome after ST-elevation myocardial infarction (STEMI) have only considered a single baseline sample, while neglecting easily obtainable peak creatine kinase and creatine kinase-MB (CK-MB) values during hospitalization. METHODS: We studied 476 patients undergoing primary percutaneous coronary intervention for STEMI and cardiac magnetic resonance imaging (CMRI) at 4-6 months after STEMI. We determined the association with cardiac biomarkers (peak CK-MB, peak troponin T, N-terminal pro-brain natriuretic peptide), clinical and angiographic characteristics with infarct size, and LVEF, followed by association with mortality in 1120 STEMI patients...
December 27, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/28008892/tunable-growth-of-perpendicular-cobalt-ferrite-nanosheets-on-reduced-graphene-oxide-for-energy-storage
#18
Bitao Dong, Mingyan Li, Chunhui Xiao, Dawei Ding, Guoxin Gao, Shujiang Ding
Ultrathin cobalt ferrite nanosheets have been successfully assembled on the surface of reduced graphene oxide (rGO) via only adjusting the volume ratio of ethanol and deionized (DI) water and a post calcination treatment. The perpendicular ultrathin cobalt ferrite nanosheets supported by rGO sheets (CoFe2O4 NSs@rGO) can be obtained when the volume ratio of ethanol and DI water is 10:30. Correspondingly, the hierarchical porous films covering the total rGO sheets will be formed nanosheets. When evaluated as the electrodes for lithium ion batteries (LIBs) and supercapacitors (SCs), the resultant CoFe2O4 NSs@rGO hybrids exhibit highly enhanced electrochemical performance...
February 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28006969/urban-and-rural-mortality-and-survival-in-medieval-england
#19
Brittany S Walter, Sharon N DeWitte
BACKGROUND: Late medieval England underwent intensive urbanisation, particularly in its largest city: London. Urban dwellers were exposed to factors such as high population density, elevated risk of infection, unsanitary living conditions and precarious food supplies. AIM: To assess whether the urban environment was more detrimental to health than the rural environment, this study compares risks of mortality and survival, as proxies for health, in medieval urban vs rural England...
January 17, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/27993539/the-association-between-hdl-particle-concentration-and-incident-metabolic-syndrome-in-the-multi-ethnic-dallas-heart-study
#20
Preethi Mani, Hao-Yu Ren, Ian J Neeland, Darren K McGuire, Colby R Ayers, Amit Khera, Anand Rohatgi
AIMS: Metabolic syndrome (MetS) increases atherosclerotic cardiovascular disease (ASCVD) risk. Low HDL cholesterol (HDL-C) is a diagnostic criterion of MetS and a major ASCVD risk factor. HDL particle concentration (HDL-P) associates with incident ASCVD independent of HDL-C, but its association with incident MetS has not been studied. We hypothesized that HDL-P would be inversely associated with incident metabolic syndrome independent of HDL-C and markers of adiposity and insulin resistance...
December 12, 2016: Diabetes & Metabolic Syndrome
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