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https://www.readbyqxmd.com/read/28430774/is-nintedanib-effective-for-idiopathic-pulmonary-fibrosis
#1
Alejandro Jeldres, Gonzalo Labarca
Idiopathic pulmonary fibrosis has poor prognosis and effective therapies are scarce. In the search for treatments that can modify the course of the disease, nintedanib (BIBF 1120), a tyrosine kinase inhibitor, has emerged as an alternative. However, its role is still unclear. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple sources of information. We identified seven systematic reviews including seven randomized trials overall. We extracted data, conducted a meta-analysis and generated a summary of findings table using the GRADE approach...
April 10, 2017: Medwave
https://www.readbyqxmd.com/read/28415046/cost-benefit-effectiveness-of-angiotensin-ii-receptor-blockers-in-patients-with-uncomplicated-hypertension-a-comparative-analysis
#2
Alberto Mazza, Antonella Paola Sacco, Danyelle M Townsend, Gianni Bregola, Edgardo Contatto, Isabella Cappello, Laura Schiavon, Emilio Ramazzina, Domenico Rubello
OBJECTIVE: The treatment of hypertensive patients (HTs) requires a long-term commitment of compliance for the patient and resources by the healthcare system. This poses an economic dilemma in countries where universal healthcare is standard. The aim of this study was to evaluate the costs/health benefit and effectiveness of treatment with angiotensin-II receptor blockers (ARBs) in uncomplicated essential hypertension. DESIGN AND METHODS: The daily and annual economic commitment for treating patients with ARBs was estimated using pharmacy dispensing records and the BP-lowering effects of candesartan, irbesartan, losartan, olmesartan, telmisartan and valsartan was evaluated retrospectively...
April 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28412645/a-hidden-structural-vulnerability-in-the-thrombospondin-2-deficient-aorta-increases-the-propensity-to-intramural-delamination
#3
C Bellini, N J Kristofik, M R Bersi, T R Kyriakides, J D Humphrey
Mice lacking thrombospondin-2 (TSP2) represent an animal model of impaired collagen fibrillogenesis. Collagen constitutes ~1/3 of the wall of the normal murine descending thoracic aorta (DTA) and is thought to confer mechanical strength at high pressures. Microstructural analysis of the DTA from TSP2-null mice revealed irregular and disorganized collagen fibrils in the adventitia and at the interface between the media and adventitia. Yet, biaxial mechanical tests performed under physiologic loading conditions showed that most mechanical metrics, including stress and stiffness, were not different between mutant and control DTAs at 20- and 40-weeks of age, thus suggesting that the absence of TSP2 is well compensated under normal conditions...
March 9, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28405593/molecular-couplings-and-energy-exchange-between-dna-and-water-mapped-by-femtosecond-infrared-spectroscopy-of-backbone-vibrations
#4
Yingliang Liu, Biswajit Guchhait, Torsten Siebert, Benjamin P Fingerhut, Thomas Elsaesser
Molecular couplings between DNA and water together with the accompanying processes of energy exchange are mapped via the ultrafast response of DNA backbone vibrations after OH stretch excitation of the water shell. Native salmon testes DNA is studied in femtosecond pump-probe experiments under conditions of full hydration and at a reduced hydration level with two water layers around the double helix. Independent of their local hydration patterns, all backbone vibrations in the frequency range from 940 to 1120 cm(-1) display a quasi-instantaneous reshaping of the spectral envelopes of their fundamental absorption bands upon excitation of the water shell...
July 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/28405345/lower-glycemic-load-meals-reduce-diurnal-glycemic-oscillations-in-women-with-risk-factors-for-gestational-diabetes
#5
Nathalie V Kizirian, Janina Goletzke, Shannon Brodie, Fiona S Atkinson, Tania P Markovic, Glynis P Ross, Anette Buyken, Jennie P Brand-Miller
OBJECTIVE: Maternal glycemia plays a key role in fetal growth. We hypothesized that lower glycemic load (GL) meals (lower glycemic index, modestly lower carbohydrate) would substantially reduce day-long glucose variability in women at risk of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: A crossover study of 17 women (mean±SD age 34.8±4 years; gestational weeks 29.3±1.3; body mass index 23.8±4.7 kg/m(2)) who consumed a low GL or a high GL diet in random order, 1-day each, over 2 consecutive days...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28390881/safe-selection-of-outpatient-joint-arthroplasty-patients-with-medical-risk-stratification-the-outpatient-arthroplasty-risk-assessment-score
#6
R Michael Meneghini, Mary Ziemba-Davis, Marshall K Ishmael, Alexander L Kuzma, Peter Caccavallo
BACKGROUND: Current patient selection criteria and medical risk stratification methods for outpatient primary total joint arthroplasty (TJA) surgery are unproven. This study assessed the predictive ability of a medically based risk assessment score in selecting patients for outpatient and short stay surgery. METHODS: A retrospective review of 1120 consecutive primary TJAs in an early discharge program was performed. An Outpatient Arthroplasty Risk Assessment ("OARA") score was developed by a high-volume arthroplasty surgeon and perioperative internal medicine specialist to stratify patients as "low-moderate risk (≤59)" and "not appropriate" (≥60) for early discharge...
March 14, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28386943/pinus-taeda-forest-growth-predictions-in-the-21-st-century-vary-with-site-mean-annual-temperature-and-site-quality
#7
Carlos A Gonzalez-Benecke, Robert O Teskey, Heather Dinon-Aldridge, Timothy A Martin
Climate projections from 20 downscaled global climate models (GCMs) were used with the 3-PG model to predict the future productivity and water use of planted loblolly pine (Pinus taeda) growing across the southeastern U.S. Predictions were made using Representative Concentration Pathways (RCP) 4.5 and 8.5. These represent scenarios in which total radiative forcing stabilizes before 2100 (RCP 4.5) or continues increasing throughout the century (RCP 8.5). Thirty six sites evenly distributed across the native range of the species were used in the analysis...
April 7, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28367775/mental-health-service-use-depression-panic-disorder-and-life-events-among-swedish-young-adults-in-2000-and-2010-a-repeated-cross-sectional-population-study-in-stockholm-county-sweden
#8
A Lundin, Y Forsell, C Dalman
AIMS: The use of specialised psychiatric services for depression and anxiety has increased steadily among young people in Sweden during recent years. It is not known to what extent this service use is due to an increase in psychiatric morbidity, or whether other adversities explain these trends. The aim of this study is to examine if there is increased use of psychiatric services among young adults in Sweden between 2000 and 2010, and if so, to what extent this increase is associated with differences in depression, anxiety and negative life events...
April 3, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28360131/a-small-molecule-screen-reveals-that-hsp90%C3%AE-promotes-the-conversion-of-ipsc-derived-endoderm-to-a-hepatic-fate-and-regulates-hnf4a-turnover
#9
Ran Jing, Cameron B Duncan, Stephen A Duncan
We have previously shown that the transcription factor HNF4A is required for the formation of hepatic progenitor cells from endoderm that has been derived from human induced pluripotent stem cells. We reasoned that we could uncover regulatory pathways with novel roles in hepatocyte differentiation by identifying cellular processes that regulate HNF4A. We, therefore, performed a screen of 1120 small molecules with well-characterized mechanisms of action to detect those that affect the abundance of HNF4A in iPSC-derived hepatic progenitor cells...
March 30, 2017: Development
https://www.readbyqxmd.com/read/28357931/monitoring-exposure-and-risk-assessment-of-sulfur-dioxide-residues-in-fresh-or-dried-fruits-and-vegetables-in-china
#10
Tiantian Lou, Weisu Huang, Xiaodan Wu, Mengmeng Wang, Liying Zhou, Baiyi Lu, Lufei Zheng, Yinzhou Hu
Sulfur dioxide residues in 20 kinds of fresh or dried fruits and vegetables collected from 23 provinces of China (Jilin, Beijing, Shanxi, Shandong, Henan, Hebei, Jiangsu, Anhui, Shanghai, Zhejiang, Fujian, Guangdong, Guangxi, Yunnan, Guizhou, Hunan, Hubei, Chongqing, Sichuan, Gansu, Neimenggu, Xinjiang, Hainan) were analyzed, and a health risk assessment was performed. The detection rates of sulfur dioxide residues in fresh vegetables, fresh fruits, dried vegetables and dried fruits were 11.1%~95.9%, 12.6%~92...
March 30, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28350034/spectrophotometric-analysis-at-the-single-cell-level-elucidating-dispersity-within-melanic-immortalized-cell-populations
#11
Luis Polo-Parada, Gerardo Gutiérrez-Juárez, David Cywiak, Rafael Pérez-Solano, Gary A Baker
It is widely held that the melanosome is an exemplar of the absorption features of melanin-containing cells, which are assumed to be uniform in both size and optical characteristics. In recent years, however, it has become increasingly apparent that this is a strikingly poor assumption. Indeed, melanin extracted from natural sources and synthetic melanin both show wide variability in their degree of polymerization (molecular weight) and spectroscopic characteristics. In the current study, imaging spectrophotometry performed on individual cells of immortalized melanin-producing cell lines revealed broad distributions in their sizes: 9...
March 28, 2017: Analyst
https://www.readbyqxmd.com/read/28303128/a-high-throughput-screening-platform-of-microbial-natural-products-for-the-discovery-of-molecules-with-antibiofilm-properties-against-salmonella
#12
Sonia Paytubi, Mercedes de La Cruz, Jose R Tormo, Jesús Martín, Ignacio González, Victor González-Menendez, Olga Genilloud, Fernando Reyes, Francisca Vicente, Cristina Madrid, Carlos Balsalobre
In this report, we describe a High-Throughput Screening (HTS) to identify compounds that inhibit biofilm formation or cause the disintegration of an already formed biofilm using the Salmonella Enteritidis 3934 strain. Initially, we developed a new methodology for growing Salmonella biofilms suitable for HTS platforms. The biomass associated with biofilm at the solid-liquid interface was quantified by staining both with resazurin and crystal violet, to detect living cells and total biofilm mass, respectively...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28302636/pharmacist-provided-medicines-reconciliation-within-24%C3%A2-hours-of-admission-and-on-discharge-a-randomised-controlled-pilot-study
#13
Brit Cadman, David Wright, Amanda Bale, Garry Barton, James Desborough, Eman A Hammad, Richard Holland, Helen Howe, Ian Nunney, Lisa Irvine
BACKGROUND: The UK government currently recommends that all patients receive medicines reconciliation (MR) from a member of the pharmacy team within 24 hours of admission and subsequent discharge. The cost-effectiveness of this intervention is unknown. A pilot study to inform the design of a future randomised controlled trial to determine effectiveness and cost-effectiveness of a pharmacist-delivered service was undertaken. METHOD: Patients were recruited 7 days a week from 5 adult medical wards in 1 hospital over a 9 month period and randomised using an automated system to intervention (MR within 24 hours of admission and at discharge) or usual care which may include MR (control)...
March 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28209612/mirna-520f-reverses-epithelial-to-mesenchymal-transition-by-targeting-adam9-and-tgfbr2
#14
Jasmijn G M van Kampen, Onno van Hooij, Cornelius F Jansen, Frank P Smit, Paula I van Noort, Iman Schultz, Roel Q J Schaapveld, Jack A Schalken, Gerald W Verhaegh
Reversing epithelial-to-mesenchymal transition (EMT) in cancer cells has been widely considered as an approach to combat cancer progression and therapeutic resistance, but a limited number of broadly comprehensive investigations of miRNAs involved in this process have been conducted. In this study, we screened a library of 1120 miRNA for their ability to transcriptionally activate the E-cadherin gene CDH1 in a promoter reporter assay as a measure of EMT reversal. By this approach, we defined miR-520f as a novel EMT-reversing miRNA...
February 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28202209/characteristics-and-prognosis-of-japanese-male-and-female-lung-cancer-patients-the-biobank-japan-project
#15
Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Makoto Hirata, Akiko Nagai, Zentaro Yamagata, Toshiharu Ninomiya, Kaori Muto, Yutaka Kiyohara, Koichi Matsuda, Yoichiro Kamatani, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi
BACKGROUND: In Japanese males and females, lung cancer is currently the second and fourth most common type of cancer, and the first and second leading cause of cancer-related deaths, respectively. METHODS: Of all Japanese male and female lung cancer patients aged ≥20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 764 males and 415 females were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry...
March 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28193045/contribution-of-ribonucleic-acid-rna-to-the-fourier-transform-infrared-ftir-spectrum-of-eukaryotic-cells
#16
Paolo Zucchiatti, Elisa Mitri, Saša Kenig, Fulvio Billè, George Kourousias, Diana Eva Bedolla, Lisa Vaccari
We report on an optimized protocol for the digestion of cellular RNA, which minimally affects the cell membrane integrity, maintaining substantially unaltered the vibrational contributions of the other cellular macromolecules. The design of this protocol allowed us to collect the first Fourier transform infrared (FTIR) spectra of intact hydrated B16 mouse melanoma cells deprived of RNA and to highlight the in-cell diagnostic spectral features of it. Complementing the cellular results with the FTIR analysis of extracted RNA, ds-DNA, ss-cDNA and isolated nuclei, we verified that the spectral component centered at ∼1220 cm(-1) is a good qualitative and semiquantitative marker of cellular DNA, since it is minimally affected by cellular RNA removal...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28187745/a-systematic-review-of-undisplaced-femoral-neck-fracture-treatments-for-patients-over-65%C3%A2-years-of-age-with-a-focus-on-union-rates-and-avascular-necrosis
#17
Dan-Feng Xu, Fang-Gang Bi, Chi-Yuan Ma, Zheng-Fa Wen, Xun-Zi Cai
BACKGROUND: It remains unclear whether conservative treatment should be used to treat the common undisplaced femoral neck fractures that develop in the elderly. Herein, we systematically review the rates of union and avascular necrosis after conservative and surgical treatment of undisplaced femoral neck fractures. METHODS: We searched the EMBASE, PubMed, OVID, Cochrane Library, Web of Science, and Scopus databases for randomized controlled trials or observational studies that assessed the outcomes of conservative or surgical treatments of undisplaced femoral neck fractures...
February 10, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28187633/integrative-taxonomy-reveals-the-first-record-and-a-new-species-for-the-previously-monotypic-genus-i-tethytimea-i-tethyida-tethyidae-in-the-gulf-of-mexico
#18
José Antonio Cruz-Barraza, Cristina Vega, Enrique Ávila, Laura Elena Vázquez-Maldonado
The first record of the previous monotypic genus Tethytimea and the description of a new species from cryptic habitats of Gulf of Mexico are presented. Tethytimea carmelita sp. nov., is a red orange cushion shaped sponge (about 5 mm thick) with a tuberculate to granular surface. The spicular complement is formed by tylostyles (200-1120 µm length), smooth spheres (12.5-55 µm in diameter); megasters-spheroxyasters (12.5-90 µm in diameter); and micrasters in two categories: oxy-strongylasters (12.5-27.5 µm in diameter) and spherotylasters (2...
January 25, 2017: Zootaxa
https://www.readbyqxmd.com/read/28173887/an-empirical-analysis-of-the-cost-of-rearing-dairy-heifers-from-birth-to-first-calving-and-the-time-taken-to-repay-these-costs
#19
A C Boulton, J Rushton, D C Wathes
Rearing quality dairy heifers is essential to maintain herds by replacing culled cows. Information on the key factors influencing the cost of rearing under different management systems is, however, limited and many farmers are unaware of their true costs. This study determined the cost of rearing heifers from birth to first calving in Great Britain including the cost of mortality, investigated the main factors influencing these costs across differing farming systems and estimated how long it took heifers to repay the cost of rearing on individual farms...
February 8, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28147598/multiple-scattering-in-random-dispersions-of-spherical-scatterers-effects-of-shear-acoustic-interactions
#20
Valerie J Pinfield, Derek Michael Forrester
The propagation of acoustic waves through a suspension of spherical particles in a viscous liquid is investigated, through application of a multiple scattering model. The model is based on the multiple scattering formulation of Luppé, Conoir, and Norris [J. Acoust. Soc. Am. 131, 1113-1120 (2012)] which incorporated the effects of thermal and shear wave modes on propagation of the acoustic wave mode. Here, the model is simplified for the case of solid particles in a liquid, in which shear waves make a significant contribution to the effective properties...
January 2017: Journal of the Acoustical Society of America
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