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Aadil Kazi, Cheryl Haslam, Myanna Duncan, Stacy Clemes, Ricardo Twumasi
This article presents baseline data from 1120 employees across 10 worksites enrolled in a workplace physical activity intervention. The study provides new data on physical activity, sedentary behaviour and health and highlights gender, geographical, job type and industrial sector differences. Sitting at work accounted for more than 60% of participants' total daily sitting time on work days. Weekly and monthly hours worked, body mass index (BMI) and waist circumference were significantly higher for workers in the private sector compared to the public sector...
June 21, 2018: Ergonomics
Yulin Lai, Liwen Zhao, Jia Hu, Jing Quan, Peijie Chen, Jinling Xu, Xin Guan, Yongqing Lai, Liangchao Ni
Subsequently to the publication of the article, the authors have recognized a need to correct some of its content in order to clarify the accuracy of the article's information. First, Dr Yongqing Lai should have been included as the joint corresponding author for this paper. Therefore, the information in the correspondence box should have been as follows (changes are indicated in bold): Correspondence to: Professor Liangchao Ni or Dr Yongqing Lai, Department of Urology, Peking University Shenzhen Hospital, 1120 Lianhua Road, Shenzhen, Guangdong 518036, P...
June 1, 2018: Molecular Medicine Reports
Yalda Baradaran-Heravi, Lubina Dillen, Hung Phuoc Nguyen, Sara Van Mossevelde, Jonathan Baets, Peter De Jonghe, Sebastiaan Engelborghs, Peter P De Deyn, Mathieu Vandenbulcke, Rik Vandenberghe, Philip Van Damme, Patrick Cras, Eric Salmon, Matthis Synofzik, Peter Heutink, Carlo Wilke, Javier Simon-Sanchez, Ricard Rojas-Garcia, Janina Turon-Sans, Alberto Lleó, Ignacio Illán-Gala, Jordi Clarimón, Barbara Borroni, Alessandro Padovani, Pau Pastor, Monica Diez-Fairen, Miquel Aguilar, Ellen Gelpi, Raquel Sanchez-Valle, Sergi Borrego-Ecija, Radoslav Matej, Eva Parobkova, Benedetta Nacmias, Sandro Sorbi, Silvia Bagnoli, Alexandre de Mendonça, Catarina Ferreira, Matthew J Fraidakis, Janine Diehl-Schmid, Panagiotis Alexopoulos, Maria Rosário Almeida, Isabel Santana, Christine Van Broeckhoven, Julie van der Zee
We evaluated the genetic contribution of the T cell-restricted intracellular antigen-1 gene (TIA1) in a European cohort of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) patients. Exonic resequencing of TIA1 in 1120 patients (693 FTD, 341 ALS, 86 FTD-ALS) and 1039 controls identified in total 5 rare heterozygous missense variants, affecting the TIA1 low-complexity domain (LCD). Only 1 missense variant, p.Met290Thr, identified in a familial FTD patient with disease onset at 64 years, was absent from controls yet received a combined annotation-dependent depletion score of 11...
May 23, 2018: Neurobiology of Aging
Qiu-Yue Zhong, Elizabeth W Karlson, Bizu Gelaye, Sean Finan, Paul Avillach, Jordan W Smoller, Tianxi Cai, Michelle A Williams
BACKGROUND: We examined the comparative performance of structured, diagnostic codes vs. natural language processing (NLP) of unstructured text for screening suicidal behavior among pregnant women in electronic medical records (EMRs). METHODS: Women aged 10-64 years with at least one diagnostic code related to pregnancy or delivery (N = 275,843) from Partners HealthCare were included as our "datamart." Diagnostic codes related to suicidal behavior were applied to the datamart to screen women for suicidal behavior...
May 29, 2018: BMC Medical Informatics and Decision Making
Aljohara A Alhassan, Ethar M Alqadhib, Nada W Taha, Raneem A Alahmari, Mahmoud Salam, Adel F Almutairi
BACKGROUND: Addiction to smartphone usage is a common worldwide problem among adults, which might negatively affect their wellbeing. This study investigated the prevalence and factors associated with smartphone addiction and depression among a Middle Eastern population. METHODS: This cross-sectional study was conducted in 2017 using a web-based questionnaire distributed via social media. Responses to the Smartphone Addiction Scale - Short version (10-items) were rated on a 6-point Likert scale, and their percentage mean score (PMS) was commuted...
May 25, 2018: BMC Psychiatry
Jan C van der Meijden, Michelle E Kruijshaar, Dimitris Rizopoulos, Pieter A van Doorn, Nadine A M E van der Beek, Ans T van der Ploeg
BACKGROUND: Pompe disease is a rare metabolic myopathy. In adult patients, progressive weakness of limb-girdle and respiratory muscles often leads to wheelchair and respirator dependency. Clinical studies have shown enzyme replacement therapy (ERT) to positively affect motor and respiratory outcomes. Here we investigate whether ERT reduces patients' risk of needing a wheelchair or respirator. METHODS: Data were collected as part of a prospective international survey, the IPA/Erasmus MC Pompe survey, which was conducted annually between 2002 and 2016...
May 22, 2018: Orphanet Journal of Rare Diseases
Catrina Banks Whitley, Jeffrey L Boyer
Ancestral Puebloan people in the North American Southwest suffered high rates of disease, poor health, and early age-at-death. Four individuals with skeletal expressions of cancer were found in a pre-Columbian population in the Taos Valley - Reports of malignant neoplasms in the archaeological record are uncommon and their presence in four of 82 individuals is a high occurrence. This study continues Whitley and Boyer's (2012) research testing whether concentrations of ionizing radiation were sufficiently high to induce cancer and related health issues...
August 23, 2017: International Journal of Paleopathology
Hai-Hsuan Cheng, Liang-Ming Whang, Tse-Fu Yi, Cheng-Pin Liu, Tsair-Fuh Lin, Mao-Song Yeh
A pilot-scale single-stage anaerobic fluidized membrane bioreactor (AFMBR) was firstly used in this study to treat cold-rolling emulsion wastewater from steel industry. It was continuously operated for 302 days with influent COD concentration of 860-1120 mg/L. Under a hydraulic retention time of 1.5 d, the average effluent COD concentration of 72 mg/L achieved corresponding 90% of COD removal. The permeate flux was varied between 1.7 and 2.9 L/m2 /h during operation which decreased with increased biomass concentration inside AFMBR...
May 9, 2018: Bioresource Technology
Miriam L Haaksma, Amaia Calderón-Larrañaga, Marcel G M Olde Rikkert, René J F Melis, Jeannie-Marie S Leoutsakos
OBJECTIVE: We sought to replicate a previously published prediction model for progression, developed in the Cache County Dementia Progression Study, using a clinical cohort from the National Alzheimer's Coordinating Center. METHODS: We included 1120 incident Alzheimer disease (AD) cases with at least one assessment after diagnosis, originating from 31 AD centres from the United States. Trajectories of the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating sum of boxes (CDR-sb) were modelled jointly over time using parallel-process growth mixture models in order to identify latent classes of trajectories...
May 15, 2018: International Journal of Geriatric Psychiatry
Tetsutaro Cho, Toru Nakajima, Yoichi Ueno, Koki Kato, Kotaro Sato
Aim: To investigate the relationship between caregiver burden and patient falls, and the incidence of falls in patients receiving home health care. Methods: A prospective cohort study was conducted on patients receiving home health care provided by 3 home-care support clinics and their primary caregivers from November 2015 to February 2016. Cox proportional hazards analysis was performed on the Burden Index of Caregivers (BIC) and the presence of falls. Results: Of the eligible 114 subjects, 47 were included in the final analysis...
May 2018: Journal of General and Family Medicine
Luísa Magalhães, Xavier de Montaudouin, Etelvina Figueira, Rosa Freitas
Resulting mainly from atmospheric carbon dioxide (CO2 ) build-up, seawater temperature rise is among the most important climate change related factors affecting costal marine ecosystems. Global warming will have implications on the water cycle, increasing the risk of heavy rainfalls and consequent freshwater input into the oceans but also increasing the frequency of extreme drought periods with consequent salinity increase. For Europe, by the end of the century, projections describe an increase of CO2 concentration up to 1120 ppm (corresponding to 0...
May 6, 2018: Science of the Total Environment
Nicole Larson, Ying Chen, Melanie Wall, Megan R Winkler, Andrea B Goldschmit, Dianne Neumark-Sztainer
There is a high prevalence of overweight among U.S. young adults and the intergenerational implications of excess weight gain at this life stage are great. We used Project EAT (Eating and Activity in Teens and Young Adults) study data to identify personal, behavioral, and environmental factors that predicted healthy weight maintenance during the transition from adolescence to adulthood and as individuals progressed from the third to fourth decade of life. The sample included 1120 young adults who were secondary school students in Minneapolis-St...
May 1, 2018: Preventive Medicine
J-M Tillema, S D Weigand, M Dayan, Y Shu, O H Kantarci, C F Lucchinetti, J D Port
BACKGROUND AND PURPOSE: The 2010 McDonald criteria are designed to sensitively detect MS; however, the low specificity of these criteria can occasionally lead to the misdiagnosis of MS. The purpose of this study was to determine whether a novel double inversion recovery MR imaging technique has the potential to increase the specificity of diagnostic criteria distinguishing MS from non-MS white matter lesions. MATERIALS AND METHODS: This was a cross-sectional observational study...
June 2018: AJNR. American Journal of Neuroradiology
Chao Guo, Bin Tuo, Tian Su, Li Ting Zheng, Xiang Yu Liu, Fang Yin, Dong He, En- Ong Yan
Understanding variation of carbon (C), nitrogen (N) and phosphorus (P) stoichiometry in common plant species across islands along a latitude gradient is insightful to reveal the adaptation strategies of plant species to environmental changes. Five common herbaceous species including Artemisia argyi, Setaira viridis, Humulus japonicus, Ophiopog onjaponicus, and Oxalis corniculata were sampled in 125 plots across nine islands in Eastern China. C, N and P contents in leaves, stems, and roots of five plant species were measured, and their relationships with soil C, N and P contents as well as mean annual air temperature (MAT) and mean annual precipitation (MAP) were investigated...
February 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Saroj Kumar Giri, Manoj Kumar Tripathi, Nachiket Kotwaliwale
Probiotic soy-cheese spread was prepared by fermenting soymilk with specific probiotic starter culture, and there after processing the coagulated mass. Soy cheese spread samples had more than 109  cfu/g of viable probiotic count at the time of preparation; and had around 17.6% protein, 25.3% fat and 19.8% total soluble sugar. Compared to commercially available dairy cheese spread, probiotic soy cheese spread had significantly higher protein and anti-oxidant activity. Soy cheese spreads, prepared from pure soymilk as well as by mixing with dairy milk, were studied with respect to the differences in their rheological behavior during storage at refrigerated conditions...
May 2018: Journal of Food Science and Technology
Ellen G East, Matthew Gabbeart, Emily Roberts, Lili Zhao, Julie M Jorns
Prolonged time from specimen excision to adequate formalin exposure, or cold ischemic time (CIT), negatively impacts estrogen receptor (ER), progesterone receptor (PR) and HER-2 biomarker studies routinely performed on breast specimens. Current guidelines recommend CIT of ≤1 h. Since formalin penetrates resections slowly, optimal fixation requires incision. We evaluated the efficacy of a rapid triage protocol developed to optimize CIT. We identified 2821 specimens: 650 (23.0%) excisional biopsies (EB), 1051 (37...
March 6, 2018: Annals of Diagnostic Pathology
Melissa G Lechner, Chirag M Vyas, Ole-Petter R Hamnvik, Erik K Alexander, P Reed Larsen, Toni K Choueiri, Trevor E Angell
BACKGROUND: Tyrosine kinase inhibitor (TKI)-induced thyroid dysfunction is recognized as a common adverse effect of treatment, but the importance of incident hypothyroidism during TKI therapy remains unclear. This study analyzed the prognostic significance of hypothyroidism during TKI therapy in cancer patients. METHODS: This was a retrospective cohort study of adult patients with advanced nonthyroidal cancer treated with TKI and available thyroid function testing at three affiliated academic hospitals from 2000 to 2017...
April 2018: Thyroid: Official Journal of the American Thyroid Association
Samantha L Yaussy, Sharon N DeWitte
Famine has the potential to target frail individuals who are at greater risk of mortality than their peers. Although children have been at elevated risk of mortality during recent famines, little is known about the risks posed to children during the medieval period. This study uses burials from the St. Mary Spital cemetery (SRP98), London (c. 1120-1540) to examine the relationships among non-adult age at death, burial type (attritional or famine), and four skeletal lesions (porotic hyperostosis, cribra orbitalia, linear enamel hypoplasia [LEH], and periosteal new bone formation)...
April 4, 2018: International Journal of Paleopathology
Minggui Pan, Mubarika Alavi, Lisa J Herrinton
INTRODUCTION: We investigated the effect of inflammatory biomarkers (neutrophil, platelet, and lymphocyte counts) on risk of progression in patients with metastatic melanoma treated with an immune checkpoint inhibitor targeting programmed cell death protein-1 (PD-1). METHODS: This retrospective cohort study included 108 patients with malignant melanoma treated with an anti-PD-1 checkpoint inhibitor from August 2014 through December 2015. The outcome was disease progression noted on imaging or clinical examination...
March 30, 2018: Permanente Journal
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