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https://www.readbyqxmd.com/read/29666519/effect-of-composition-and-storage-time-on-some-physico-chemical-and-rheological-properties-of-probiotic-soy-cheese-spread
#1
Saroj Kumar Giri, Manoj Kumar Tripathi, Nachiket Kotwaliwale
Probiotic soy-cheese spread was prepared by fermenting soymilk with specific probiotic starter culture, and there after processing the coagulated mass. Soy cheese spread samples had more than 109  cfu/g of viable probiotic count at the time of preparation; and had around 17.6% protein, 25.3% fat and 19.8% total soluble sugar. Compared to commercially available dairy cheese spread, probiotic soy cheese spread had significantly higher protein and anti-oxidant activity. Soy cheese spreads, prepared from pure soymilk as well as by mixing with dairy milk, were studied with respect to the differences in their rheological behavior during storage at refrigerated conditions...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29661737/a-rapid-triage-protocol-to-optimize-cold-ischemic-time-for-breast-resection-specimens
#2
Ellen G East, Matthew Gabbeart, Emily Roberts, Lili Zhao, Julie M Jorns
Prolonged time from specimen excision to adequate formalin exposure, or cold ischemic time (CIT), negatively impacts estrogen receptor (ER), progesterone receptor (PR) and HER-2 biomarker studies routinely performed on breast specimens. Current guidelines recommend CIT of ≤1 h. Since formalin penetrates resections slowly, optimal fixation requires incision. We evaluated the efficacy of a rapid triage protocol developed to optimize CIT. We identified 2821 specimens: 650 (23.0%) excisional biopsies (EB), 1051 (37...
March 6, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29652597/hypothyroidism-during-tyrosine-kinase-inhibitor-therapy-is-associated-with-longer-survival-in-patients-with-advanced-nonthyroidal-cancers
#3
Melissa G Lechner, Chirag M Vyas, Ole-Petter R Hamnvik, Erik K Alexander, P Reed Larsen, Toni K Choueiri, Trevor E Angell
BACKGROUND: Tyrosine kinase inhibitor (TKI)-induced thyroid dysfunction is recognized as a common adverse effect of treatment, but the importance of incident hypothyroidism during TKI therapy remains unclear. This study analyzed the prognostic significance of hypothyroidism during TKI therapy in cancer patients. METHODS: This was a retrospective cohort study of adult patients with advanced nonthyroidal cancer treated with TKI and available thyroid function testing at three affiliated academic hospitals from 2000 to 2017...
April 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29626661/patterns-of-frailty-in-non-adults-from-medieval-london
#4
Samantha L Yaussy, Sharon N DeWitte
Famine has the potential to target frail individuals who are at greater risk of mortality than their peers. Although children have been at elevated risk of mortality during recent famines, little is known about the risks posed to children during the medieval period. This study uses burials from the St. Mary Spital cemetery (SRP98), London (c. 1120-1540) to examine the relationships among non-adult age at death, burial type (attritional or famine), and four skeletal lesions (porotic hyperostosis, cribra orbitalia, linear enamel hypoplasia [LEH], and periosteal new bone formation)...
April 4, 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29616914/association-of-inflammatory-markers-with-disease-progression-in-patients-with-metastatic-melanoma-treated-with-immune-checkpoint-inhibitors
#5
Minggui Pan, Mubarika Alavi, Lisa J Herrinton
INTRODUCTION: We investigated the effect of inflammatory biomarkers (neutrophil, platelet, and lymphocyte counts) on risk of progression in patients with metastatic melanoma treated with an immune checkpoint inhibitor targeting programmed cell death protein-1 (PD-1). METHODS: This retrospective cohort study included 108 patients with malignant melanoma treated with an anti-PD-1 checkpoint inhibitor from August 2014 through December 2015. The outcome was disease progression noted on imaging or clinical examination...
March 30, 2018: Permanente Journal
https://www.readbyqxmd.com/read/29611229/relationship-between-environmental-factors-age-of-onset-and-familial-history-in-japanese-patients-with-psoriasis
#6
Bolortuya Bayaraa, Shinichi Imafuku
Psoriasis is a chronic inflammatory disease that often involves the skin and joints. Psoriasis develops at any age and the distribution of age of onset of psoriasis is bimodal in Japan. Also, male predominance is distinct in Japanese psoriatic patients. To clarify the relationship between sex difference and habitual/environmental status, age and incidence of familial psoriasis, we analyzed data from the Fukuoka University Psoriasis Registry. A total of 1120 Japanese patients (751 men, 369 women) were analyzed...
April 3, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29607495/acupuncture-for-acute-stroke
#7
REVIEW
Mangmang Xu, Dan Li, Shihong Zhang
BACKGROUND: Sensory stimulation via acupuncture has been reported to alter activities of numerous neural systems by activating multiple efferent pathways. Acupuncture, one of the main physical therapies in Traditional Chinese Medicine, has been widely used to treat patients with stroke for over hundreds of years. This is the first update of the Cochrane Review originally published in 2005. OBJECTIVES: To assess whether acupuncture could reduce the proportion of people with death or dependency, while improving quality of life, after acute ischemic or hemorrhagic stroke...
March 30, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29577605/increased-factor-viii-plays-a-significant-role-in-plasma-hypercoagulability-phenotype-of-patients-with-cirrhosis
#8
Thomas Sinegre, Cédric Duron, Thomas Lecompte, Bruno Pereira, Sylvie Massoulier, Géraldine Lamblin, Armand Abergel, Aurélien Lebreton
BACKGROUND: In cirrhosis, thrombin generation (TG) studied in the presence of thrombomodulin (TM) indicates plasma hypercoagulability. Although the role of protein C (PC) deficiency has been investigated, the influence of factor VIII (FVIII) increase has never been addressed. OBJECTIVES: We investigated the roles of high FVIII and low PC in increased TG performed with TM. METHODS: Blood samples were prospectively collected from 35 healthy controls and 93 patients with cirrhosis (n=61 Child-Turcotte-Pugh (CTP) A, n=19 CTP-B, and n=13 CTP-C) and FVIII levels >150% (n=48) and/or PC levels <70% (n=88)...
March 26, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29547661/a-fully-automated-image-analysis-method-to-quantify-lung-fibrosis-in-the-bleomycin-induced-rat-model
#9
Shanon Seger, Manuel Stritt, Enrico Vezzali, Oliver Nayler, Patrick Hess, Peter M A Groenen, Anna K Stalder
Intratracheal administration of bleomycin induces fibrosis in the lung, which is mainly assessed by histopathological grading that is subjective. Current literature highlights the need of reproducible and quantitative pulmonary fibrosis analysis. If some quantitative studies looked at fibrosis parameters separately, none of them quantitatively assessed both aspects: lung tissue remodeling and collagenization. To ensure reliable quantification, support vector machine learning was used on digitalized images to design a fully automated method that analyzes two important aspects of lung fibrosis: (i) areas having substantial tissue remodeling with appearance of dense fibrotic masses and (ii) collagen deposition...
2018: PloS One
https://www.readbyqxmd.com/read/29534500/burden-of-severe-fungal-infections-in-burkina-faso
#10
Sanata Bamba, Adama Zida, Ibrahim Sangaré, Mamoudou Cissé, David W Denning, Christophe Hennequin
Because of the limited access to more powerful diagnostic tools, there is a paucity of data regarding the burden of fungal infections in Burkina Faso. The aim of this study was to estimate the incidence and prevalence of serious fungal infections in this sub-Saharan country. We primarily used the national demographic data and performed a PubMed search to retrieve all published papers on fungal infections from Burkina Faso and its surrounding West African countries. Considering the prevalence of HIV infection (0...
March 11, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29517177/basilic-vein-transposition-for-unsuitable-upper-arm-hemodialysis-needle-access-segment-may-attenuate-concurrent-hand-ischemia
#11
Michael W M Gerrickens, Roel H D Vaes, Bastiaan Govaert, Joep A W Teijink, Marc R Scheltinga
INTRODUCTION: Some hemodialysis patients with a brachial arteriovenous fistula (AVF) have an unsuitable upper arm needle access segment (NAS) necessitating basilic vein transposition (BVT). It was frequently observed that a portion of these patients spontaneously experienced a warmer and less painful dialysis hand after BVT. Aim of this study was to determine whether BVT for an inadequate NAS attenuated hemodialysis access-induced distal ischemia in patients with a brachial AVF. METHODS: Patients with a brachial AVF and an unsuitable NAS also reporting hand ischemia and scheduled to undergo BVT between 2005 and 2016 in a single facility were studied...
March 8, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29510321/the-use-of-%C3%AE-rays-analysis-by-hpge-detector-to-assess-the-gross-alpha-and-beta-activities-in-waters
#12
M F S Casagrande, D M Bonotto
This paper describes an alternative method for evaluating gross alpha and beta radioactivity in waters by using γ-rays analysis performed with hyper-pure germanium detector (HPGe). Several gamma emissions related to α and β- decays were used to provide the activity concentration data due to natural radionuclides commonly present in waters like40 K and those belonging to the238 U and232 Th decay series. The most suitable gamma emissions related to β- decays were214 Bi (1120.29 keV,238 U series) and208 Tl (583...
February 23, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29492086/multidisciplinary-team-mdt-meeting-and-radiologist-workload-a-prospective-review-in-a-tertiary-care-hospital
#13
Sadaf Nasir, Saleha Anwar, Moinuddin Ahmed
Objective: To quantify the increase in workload associated with multidisciplinary team meetings for radiologists in a tertiary care hospital over a period of 15 months. Methods: Data was collected prospectively regarding number of multidisciplinary team meetings, number of clinical cases discussed, number of individual imaging studies reviewed, and preparation time of residents, senior registrar and consultants and the delivery time of meeting. Results: Total 223 meetings were held over 15 months (April 2014 to June 2015) for 12 clinical specialty areas...
November 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29475294/highly-efficient-nanosecond-560-nm-source-by-shg-of-a-combined-yb-raman-fiber-amplifier
#14
T H Runcorn, R T Murray, J R Taylor
We demonstrate a nanosecond 560 nm pulse source based on frequency-doubling the output of a combined Yb-Raman fiber amplifier, achieving a pulse energy of 2.0 µJ with a conversion efficiency of 32% from the 976 nm pump light. By introducing a continuous-wave 1120 nm signal before the cladding pumped amplifier of a pulsed Yb:fiber master oscillator power amplifier system operating at 1064 nm, efficient conversion to 1120 nm occurs within the fiber amplifier due to stimulated Raman scattering. The output of the combined Yb-Raman amplifier is frequency-doubled to 560 nm using a periodically poled lithium tantalate crystal with a conversion efficiency of 47%, resulting in an average power of 3...
February 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29453300/school-based-lifestyle-education-involving-parents-for-reducing-subjective-psychosomatic-symptoms-in-japanese-adolescents-study-protocol-for-a-cluster-randomised-controlled-trial
#15
Junko Watanabe, Mariko Watanabe, Kazue Yamaoka, Misa Adachi, Asuka Nemoto, Toshiro Tango
INTRODUCTION: Severe subjective psychosomatic symptoms (SPS) in adolescents are a major public health concern, and lifestyle modification interventions for reducing SPS are important topics. Recently, we developed a school-based lifestyle education involving parents for reducing SPS of adolescents (SPRAT), an improved version of the programme from our previous study Programme for adolescent of lifestyle education in Kumamoto (PADOK). This study aimed to evaluate the effectiveness of SPRAT in reducing SPS among adolescents...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29451143/familial-nonmedullary-thyroid-carcinoma-a-retrospective-analysis-of-117-families
#16
Ya-Bing Zhang, Xiao-Xin Wang, Xi-Wei Zhang, Zheng-Jiang Li, Jie Liu, Zhen-Gang Xu, Ping-Zhang Tang
Background: The first and most important step in characterizing familial nonmedullary thyroid carcinoma (NMTC) is to distinguish the true familial patients, which is the prerequisite for all accurate analyses. This study aimed to investigate whether patients from families with ≥3 first-degree relatives affected with NMTC have different characteristics than patients from families with only two affected members, and to compare these patients with those with sporadic disease. Methods: We analyzed the clinicopathological features and prognosis of 209 familial and 1120 sporadic cases of NMTC...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29423211/depressive-affect-in-incident-hemodialysis-patients
#17
Kathryn A McDougall, John W Larkin, Rebecca L Wingard, Yue Jiao, Sophia Rosen, Lin Ma, Len A Usvyat, Franklin W Maddux
Background: The prevalence of depressive affect is not well defined in the incident hemodialysis (HD) population. We investigated the prevalence of and associated risk factors and hospitalization rates for depressive affect in incident HD patients. Methods: We performed a prospective investigation using the Patient Health Questionnaire 2 (PHQ2) depressive affect assessment. From January to July of 2013 at 108 in-center clinics randomly selected across tertiles of baseline quality measures, we contacted 577 and 543 patients by telephone for depressive affect screening...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29406563/spectrum-of-apc-and-mutyh-germ-line-mutations-in-russian-patients-with-colorectal-malignancies
#18
G A Yanus, T A Akhapkina, A O Ivantsov, E V Preobrazhenskaya, S N Aleksakhina, I V Bizin, A P Sokolenko, N V Mitiushkina, E Sh Kuligina, E N Suspitsin, A R Venina, M M Holmatov, O A Zaitseva, O S Yatsuk, D V Pashkov, A M Belyaev, A V Togo, E N Imyanitov, A G Iyevleva
Distribution of cancer-predisposing mutations demonstrates significant interethnic variations. This study aimed to evaluate patterns of APC and MUTYH germ-line mutations in Russian patients with colorectal malignancies. APC gene defects were identified in 26/38 (68%) subjects with colon polyposis; 8/26 (31%) APC mutations were associated with 2 known mutational hotspots (p.E1309Dfs*4 [n = 5] and p.Q1062fs* [n = 3]), while 6/26 (23%) mutations were novel (p.K73Nfs*6, p.S254Hfs*12, p.S1072Kfs*9, p.E1547Kfs*11, p...
February 6, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29401610/an-image-based-small-molecule-screen-identifies-vimentin-as-a-pharmacologically-relevant-target-of-simvastatin-in-cancer-cells
#19
Kathryn P Trogden, Rachel A Battaglia, Parijat Kabiraj, Victoria J Madden, Harald Herrmann, Natasha T Snider
Vimentin is a cytoskeletal intermediate filament protein that is expressed in mesenchymal cells and cancer cells during the epithelial-mesenchymal transition. The goal of this study was to identify vimentin-targeting small molecules by using the Tocriscreen library of 1120 biochemically active compounds. We monitored vimentin filament reorganization and bundling in adrenal carcinoma SW13 vimentin-positive (SW13-vim+) cells via indirect immunofluorescence. The screen identified 18 pharmacologically diverse hits that included 2 statins-simvastatin and mevastatin...
January 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29400618/the-longitudinal-relationship-between-generalized-self-efficacy-and-physical-activity-in-school-aged-children
#20
Yao-Chuen Li, Divya Joshi, Sara King-Dowling, John Hay, Brent E Faught, John Cairney
Our understanding of the longitudinal relationship between generalized self-efficacy (GSE) and physical activity in children and youth is limited. The purpose of this study was to investigate the effect of GSE towards physical activity on sedentary behaviours and physical activity in school-aged children over time. A total of 2278 nine-year-old children (1120 girls and 1158 boys) were recruited at baseline and followed for seven waves of data collection from 2005 to 2008. All children completed questionnaires at each wave assessing their GSE (adequacy, predilection, and enjoyment), sedentary behaviours, free play, and organized activity...
February 5, 2018: European Journal of Sport Science
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