keyword
https://read.qxmd.com/read/38531811/changes-in-perampanel-pharmacokinetics-and-cytochrome-p450-3a4-activity-before-during-and-after-pregnancy
#1
JOURNAL ARTICLE
Yoshiaki Yamamoto, Naoto Akita, Hiroki Nogimoto, Wakana Suzuki, Katsumi Imai, Yukitoshi Takahashi, Yoshiyuki Kagawa
This study evaluated perampanel pharmacokinetics and cytochrome P450 3A4 (CYP3A4) activity, assessed using the level of 4β-hydroxycholesterol (4β-OHC) as an endogenous biomarker of CYP3A4, before, during, and after pregnancy in a woman with epilepsy and compared these measurements with those from a control group of nonpregnant women with epilepsy. A 21-year-old pregnant woman was being treated with perampanel (serum concentration: 1120 ng/mL), lacosamide, and lamotrigine. After the first trimester, the lamotrigine concentration decreased markedly; however, the perampanel concentration remained almost unchanged (range, 1130-1320 ng/mL)...
March 26, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38506282/effect-of-guided-implant-placement-learning-experiences-on-freehand-skills-a-pilot-study
#2
JOURNAL ARTICLE
Caroline Carrico, Lenart Skrjanc, Domen Kanduti, George Deeb, Janina Golob Deeb
OBJECTIVES: Guided implant systems can be used as a training approach for placing implants. This in vitro prospective randomized pilot study evaluated the learning progression and skill development in freehand placement of two implants supporting a three-unit fixed prosthesis on a simulation model among novice operators. MATERIAL AND METHODS: Four senior dental students with no prior implant placement experience participated in the study. As a baseline, each student placed two mandibular and two maxillary implants by freehand technique on a simulation model...
April 2024: Clinical and Experimental Dental Research
https://read.qxmd.com/read/38493709/enterovirus-and-parechovirus-meningoencephalitis-in-infants-a-ten-year-prospective-observational-study-in-a-neonatal-intensive-care-unit
#3
JOURNAL ARTICLE
Carlo Pietrasanta, Andrea Ronchi, Laura Bassi, Agnese De Carli, Luca Caschera, Francesco Maria Lo Russo, Beatrice Letizia Crippa, Silvia Pisoni, Riccardo Crimi, Giacomo Artieri, Laura Pellegrinelli, Robertino Dilena, Giorgio Conte, Fabio Mosca, Monica Fumagalli, Lorenza Pugni
BACKGROUND: Non-polio enteroviruses (EV) and human parechoviruses (HPeV) are known etiological agents of meningoencephalitis in neonates. However, reports of neuroradiological findings and neurodevelopmental outcomes in this population are scarce. OBJECTIVES: to describe clinical characteristics, neuroradiological findings and, in a subset of patients, neurodevelopmental outcomes in a cohort of infants with EV or HPeV meningoencephalitis within 60 days of life. STUDY DESIGN: clinical/laboratory data, neuroradiological findings (cranial ultrasound, cUS, brain magnetic resonance imaging, MRI), and neurodevelopmental outcomes assessed by Ages and Stages Questionnaires - third edition were prospectively collected...
March 5, 2024: Journal of Clinical Virology
https://read.qxmd.com/read/38488955/clinical-effectiveness-of-pit-and-fissure-sealants-in-primary-and-permanent-teeth-of-children-and-adolescents-an-umbrella-review
#4
S Amend, C Boutsiouki, J Winter, D Kloukos, R Frankenberger, N Krämer
PURPOSE: This umbrella review aimed to critically appraise the evidence published in systematic reviews (SRs) on the clinical effectiveness of sealants compared with each other/the non-use in primary/permanent teeth of children and adolescents with at least 12-month follow-up. METHODS: A systematic literature search on 4 electronic databases was conducted up to January 18th, 2023. Following handsearching, two review authors independently screened retrieved articles, extracted data, and assessed the risk of bias (RoB) using the risk of bias in systematic reviews (ROBIS) tool...
March 15, 2024: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://read.qxmd.com/read/38485689/self-reported-preoperative-depressive-symptoms-and-survival-after-cardiac-surgery
#5
JOURNAL ARTICLE
Anna Falk, Ulrik Sartipy, Malin Stenman
OBJECTIVES: Depression has been associated with increased cardiovascular morbidity and mortality. This study aimed to determine whether self-reported preoperative depressive symptoms were associated with worse long-term survival in patients undergoing cardiac surgery. METHODS: This population-based, observational cohort study included patients who had undergone cardiac surgery at Karolinska University Hospital between 2013 and 2016. Self-reported data about depressive symptoms were collected using the Patient Health Questionnaire (PHQ-9) and other patient data were collected from the institutional surgical database and medical charts...
March 14, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38482032/enhanced-sunlight-driven-catalysis-for-hydrogen-generation-and-dye-remediation-using-synergistic-p-co-3-o-4-n-tio-2-nanocomposites
#6
JOURNAL ARTICLE
Sandhya S Gadge, Ratna Chauhan, Dattatray J Late, Indra Jeet Chaudhary, Muthupandian Ashokkumar, Suresh Gosavi
In this study, p-Co3 O4 /n-TiO2 nanocomposites were synthesized using different ratios of cobalt and titanium precursors through a hydrothermal method. These nanocomposites demonstrated notable potential in photocatalytic applications for hydrogen production and orange-red dye degradation under sunlight. Various techniques, including XRD, Raman spectroscopy, XPS, FESEM, TEM, and BET analysis, were used to comprehensively characterize their structural, morphological, and optical properties. The nanocomposites exhibited both cubic and tetragonal phases of Co3 O4 and TiO2 , and their combined effect resulted in a narrowed band gap...
March 12, 2024: Nanoscale advances
https://read.qxmd.com/read/38476518/predicting-postsurgical-complications-of-peripheral-nerve-decompression-nsqip-analysis-of-frailty-measures-versus-historic-proxies
#7
JOURNAL ARTICLE
Arya A Akhavan, Helen Liu, Eric Alerte, Taylor Ibelli, Suhas K Etigunta, Abigail Katz, Annet S Kuruvilla, Peter J Taub
BACKGROUND: Peripheral nerve decompression (PND) is generally safe, and newer techniques allow frail patients to undergo PND at less common sites. Current literature suggests patient frailty measures may more accurately predict postsurgical complications versus other proxies, but no current literature examines frailty in PND. METHODS: The authors reviewed data from the National Surgical Quality Improvement Program for patients who underwent PND outside the most common sites from 2013 to 2019...
2024: Eplasty
https://read.qxmd.com/read/38464931/efficacy-and-safety-of-remimazolam-in-bronchoscopic-sedation-a-meta-analysis
#8
JOURNAL ARTICLE
Ying Zhou, Cheng Zhao, Yi-Xun Tang, Ji-Tong Liu
BACKGROUND: Remimazolam is a new benzodiazepine used for procedural sedation and general anesthesia. Several studies have used remimazolam for bendable bronchoscopy. AIM: To assess the safety and efficacy of remimazolam for sedation in patients undergoing bendable bronchoscopy by performing a meta-analysis of randomized controlled trials (RCTs). METHODS: We searched the EMBASE, PubMed, Cochrane Library, and Web of Science databases for RCTs on bendable bronchoscopic procedural sedation with remimazolam vs conventional sedatives (CS)...
February 26, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38457590/intelligent-diagnosis-of-lung-nodule-images-based-on-machine-learning-in-the-context-of-lung-teaching
#9
JOURNAL ARTICLE
Miaomiao Li, Lilei Zhuang, Sheng Hu, Li Sun, Yangxiang Liu, Zhengwei Dou, Tao Jiang
The vast majority of intelligent diagnosis models have widespread problems, which seriously affect the medical staff judgment of patients' injuries. So depending on the situation, you need to use different algorithms, The study suggests a model for intelligent diagnosis of lung nodule images based on machine learning, and a support vector machine-based machine learning algorithm is selected. In order to improve the diagnostic accuracy of intelligent diagnosis of lung nodule images as well as the diagnostic model of lung nodule images...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38456532/influence-of-repulsion-on-entropy-scaling-and-density-scaling-of-monatomic-fluids
#10
JOURNAL ARTICLE
Denis Saric, Ian H Bell, Gabriela Guevara-Carrion, Jadran Vrabec
Entropy scaling is applied to the shear viscosity, self-diffusion coefficient, and thermal conductivity of simple monatomic fluids. An extensive molecular dynamics simulation series is performed to obtain these transport properties and the residual entropy of three potential model classes with variable repulsive exponents: n, 6 Mie (n = 9, 12, 15, and 18), Buckingham's exponential-six (α = 12, 14, 18, and 30), and Tang-Toennies (αT = 4.051, 4.275, and 4.600). A wide range of liquid and supercritical gas- and liquid-like states is covered with a total of 1120 state points...
March 14, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38426231/improving-the-measurement-properties-of-the-amyotrophic-lateral-sclerosis-functional-rating-scale-revised-alsfrs-r-deriving-a-valid-measurement-total-for-the-calculation-of-change
#11
JOURNAL ARTICLE
Carolyn A Young, Amina Chaouch, Christopher J Mcdermott, Ammar Al-Chalabi, Suresh K Chhetri, Kevin Talbot, Andrea Malaspina, Roger Mills, Alan Tennant
BACKGROUND: The Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) total score is a widely used measure of functional status in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS), but recent evidence has raised doubts about its validity. The objective was to examine the measurement properties of the ALSFRS-R, aiming to produce valid measurement from all 12 scale items. METHOD: Longitudinal ALSFRS-R data were collected between 2013-2020 from 1120 people with ALS recruited from 35 centers, together with other scales in the Trajectories of Outcomes in Neurological Conditions-ALS (TONiC-ALS) study...
March 1, 2024: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://read.qxmd.com/read/38416484/abatacept-could-prevent-progression-to-rheumatoid-arthritis
#12
JOURNAL ARTICLE
Emily Harris
No abstract text is available yet for this article.
February 28, 2024: JAMA
https://read.qxmd.com/read/38399047/effect-of-silicon-dioxide-nanoparticles-on-the-sintering-properties-of-beta-tricalcium-phosphate-composites
#13
JOURNAL ARTICLE
Kazuaki Hashimoto, Masahiko Oiwa, Hirobumi Shibata
Composite sintered bodies comprising silicon dioxide (SiO2 ) nanoparticles dispersed in β-tricalcium phosphate (β-TCP) were prepared. The addition of nano-sized colloidal SiO2 to the β-TCP produced well-dispersed secondary phase nanoparticles that promoted densification by suppressing grain growth and increasing linear shrinkage of the sintered bodies. The SiO2 was found not to react with the β-TCP at 1120 °C and the substitution of silicon for phosphorous to produce a solid solution did not occur...
February 7, 2024: Materials
https://read.qxmd.com/read/38397387/mapping-expression-quantitative-trait-loci-targeting-candidate-genes-for-pregnancy-in-beef-cows
#14
JOURNAL ARTICLE
Wellison J S Diniz, Juliana Afonso, Nicholas C Kertz, Paul W Dyce, Priyanka Banerjee
Despite collective efforts to understand the complex regulation of reproductive traits, no causative genes and/or mutations have been reported yet. By integrating genomics and transcriptomics data, potential regulatory mechanisms may be unveiled, providing opportunities to dissect the genetic factors governing fertility. Herein, we identified regulatory variants from RNA-Seq data associated with gene expression regulation in the uterine luminal epithelial cells of beef cows. We identified 4676 cis and 7682 trans eQTLs (expression quantitative trait loci) affecting the expression of 1120 and 2503 genes, respectively (FDR < 0...
January 26, 2024: Biomolecules
https://read.qxmd.com/read/38376273/identification-of-key-gene-signatures-and-their-characterization-by-expression-correlation-with-drug-sensitivity-in-smoking-associated-oral-squamous-cell-carcinoma
#15
JOURNAL ARTICLE
Pavan Gollapalli, Dhananjay Alagundagi, Sudeep D Ghate, Vijith V Shetty, Praveenkumar Shetty, Prakash Patil
AIMS: Oral squamous cell carcinoma (OSCC), a most frequent type of head-and-neck cancer, is becoming more common and posing a substantial health risk. Using a network biology strategy, this study intended to find and investigate critical genes associated with OSCC. MATERIALS AND METHODS: The extended protein-protein interaction networks for differentially expressed genes related to smoking and nonsmoking conditions of OSCC were constructed and visualized using Cytoscape software...
October 1, 2023: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/38373959/deeprisk-network-an-ai-based-tool-for-digital-pathology-signature-and-treatment-responsiveness-of-gastric-cancer-using-whole-slide-images
#16
JOURNAL ARTICLE
Mengxin Tian, Zhao Yao, Yufu Zhou, Qiangjun Gan, Leihao Wang, Hongwei Lu, Siyuan Wang, Peng Zhou, Zhiqiang Dai, Sijia Zhang, Yihong Sun, Zhaoqing Tang, Jinhua Yu, Xuefei Wang
BACKGROUND: Digital histopathology provides valuable information for clinical decision-making. We hypothesized that a deep risk network (DeepRisk) based on digital pathology signature (DPS) derived from whole-slide images could improve the prognostic value of the tumor, node, and metastasis (TNM) staging system and offer chemotherapeutic benefits for gastric cancer (GC). METHODS: DeepRisk is a multi-scale, attention-based learning model developed on 1120 GCs in the Zhongshan dataset and validated with two external datasets...
February 19, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38368273/triple-cross-linking-engineering-strategies-for-efficient-and-stable-inverted-flexible-perovskite-solar-cells
#17
JOURNAL ARTICLE
Silong Tu, Yong Gang, Yuanqiong Lin, Xinyue Liu, Yi Zhong, Daquan Yu, Xin Li
Inverted flexible perovskite solar cells (fPSCs) are promising for commercialization due to their low cost, lightweight, and excellent stability. However, enhancing fPSCs' power conversion efficiency and stability remains challenging. Here, an unprecedented triple cross-linking engineering strategy is innovatively exhibit for efficient and stable inverted fPSCs. First, a carefully designed cross-linker, 4-fluorophenyl 5-(1,2-dithiolan-3-yl) pentanoate (FB-TA), is added to the perovskite precursor solution. During the perovskite film's crystallization at a low temperature, the cross-linking product of FB-TA can passivate the grain boundaries and reduce the film's residual strain and Young's module...
February 17, 2024: Small
https://read.qxmd.com/read/38350229/an-a-d-a-d-a-type-narrow-bandgap-electron-acceptor-based-on-selenophene-flanked-diketopyrrolopyrrole-for-sensitive-near-infrared-photodetection
#18
REVIEW
Yeye Wang, Mingqun Yang, Bingyan Yin, Baoqi Wu, Guoqiang Liu, Seonghun Jeong, Yue Zhang, Changduk Yang, Zhicai He, Fei Huang, Yong Cao, Chunhui Duan
Near-infrared organic photodetectors possess great application potential in night vision, optical communication, and image sensing, but their development is limited by the lack of narrow bandgap organic semiconductors. A-D-A'-D-A-type molecules, featuring multiple intramolecular charge transfer effects, offer a robust framework for achieving near-infrared light absorption. Herein, we report a novel A-D-A'-D-A-type narrow bandgap electron acceptor named DPPSe-4Cl, which incorporates a selenophene-flanked diketopyrrolopyrrole (Se-DPP) unit as its central A' component...
February 13, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38339266/development-and-validation-of-a-concise-objectifiable-risk-evaluation-score-for-non-relapse-mortality-after-allogeneic-hematopoietic-stem-cell-transplantation
#19
JOURNAL ARTICLE
Gunnar Weise, Radwan Massoud, Rolf Krause, Silke Heidenreich, Dietlinde Janson, Evgeny Klyuchnikov, Christine Wolschke, Gaby Zeck, Nicolaus Kröger, Francis Ayuk
We aimed to develop a concise objectifiable risk evaluation (CORE) tool for predicting non-relapse mortality (NRM) and overall survival (OS) after allogeneic hematopoietic stem cell transplantation (allo-HCT). A total of 1120 adult patients who had undergone allo-HCT at our center between 2013 and 2020 were divided into training, first, and second validation cohorts. Objectifiable, patient-related factors impacting NRM in univariate and multivariate analyses were: serum albumin, serum creatinine, serum C-reactive protein (CRP), heart function (LVEF), lung function (VC, FEV1), and patient age...
January 25, 2024: Cancers
https://read.qxmd.com/read/38329487/myelomonocytic-and-monocytic-acute-myeloid-leukemia-demonstrate-comparable-poor-outcomes-with-venetoclax-based-treatment-a-monocentric-real-world-study
#20
JOURNAL ARTICLE
Lei Zhao, Jinjun Yang, Mengran Chen, Xinrong Xiang, Hongbing Ma, Ting Niu, Yuping Gong, Xinchuan Chen, Jiazhuo Liu, Yu Wu
Venetoclax (VEN), a BCL-2 inhibitor, has transformed treatment strategies for elderly and unfit acute myeloid leukemia (AML) patients by significantly improving response rates and survival. However, the predictive factors for VEN efficacy differ from traditional chemotherapy. The clinical relevance of the FAB (French-American-British) monocytic subtype, including M4 and M5, has been debated as a marker for VEN resistance. This real-world study examined 162 newly diagnosed (ND) and 85 relapsed/refractory (R/R) AML patients who received VEN-based therapy at West China Hospital, Sichuan University, from January 2019 to January 2023...
February 8, 2024: Annals of Hematology
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