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https://www.readbyqxmd.com/read/27921142/intra-population-variability-of-ocean-acidification-impacts-on-the-physiology-of-baltic-blue-mussels-mytilus-edulis-integrating-tissue-and-organism-response
#1
L S Stapp, J Thomsen, H Schade, C Bock, F Melzner, H O Pörtner, G Lannig
Increased maintenance costs at cellular, and consequently organism level, are thought to be involved in shaping the sensitivity of marine calcifiers to ocean acidification (OA). Yet, knowledge of the capacity of marine calcifiers to undergo metabolic adaptation is sparse. In Kiel Fjord, blue mussels thrive despite periodically high seawater PCO2, making this population interesting for studying metabolic adaptation under OA. Consequently, we conducted a multi-generation experiment and compared physiological responses of F1 mussels from 'tolerant' and 'sensitive' families exposed to OA for 1 year...
December 5, 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/27916446/gastrointestinal-complications-associated-with-the-surgical-treatment-of-heart-disease-in-children
#2
Lee P Ferguson, Tarriyo Gandiya, Christos Kaselas, Jigna Sheth, Asif Hasan, Hany Os Gabra
BACKGROUND/PURPOSE: The gastrointestinal system is prone to complications following heart surgery. We sought to determine the incidence and factors associated with gastrointestinal complication after cardiac surgery in children. METHODS: A retrospective review of patients aged <16years that underwent cardiac surgery between 2009 and 2013. Primary outcome was occurrence of gastrointestinal complication within 30days. Multivariable logistic regression was performed to identify variables related to occurrence of gastrointestinal complication...
November 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27883969/drug-drug-interactions-in-the-intensive-care-unit-do-they-really-matter
#3
D Vanham, A Spinewine, Ph Hantson, X Wittebole, D Wouters, B Sneyers
PURPOSE: To describe prevalence and patterns of potential drug-drug interactions (pDDIs) in the intensive care unit (ICU), occurrence of adverse drug events (ADEs), and agreement between different compendia and intensivists' perceptions. METHODS: A cross-sectional study. Drug profiles of all adult patients from 2 academic ICUs were screened on day 3 upon admission. We identified pDDIs using 3 compendia (Stockley's, Micromedex, and Epocrates) and documented their mechanism of action, clinical consequences, severity, level of evidence, and management...
October 4, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27869858/method-for-large-range-structured-light-system-calibration
#4
Yatong An, Tyler Bell, Beiwen Li, Jing Xu, Song Zhang
Structured light system calibration often requires the usage of a calibration target with a similar size as the field of view (FOV), which brings challenges to a large-range structured light system calibration since fabricating large calibration targets is difficult and expensive. This paper presents a large-range system calibration method that does not need a large calibration target. The proposed method includes two stages: (1) accurately calibrate intrinsics (i.e., focal lengths and principle points) at a near range where both the camera and projector are out of focus, and (2) calibrate the extrinsic parameters (translation and rotation) from camera to projector with the assistance of a low-accuracy, large-range three-dimensional (3D) sensor (e...
November 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27850757/1120-existing-disease-severity-scoring-systems-and-their-utility-in-an-ed-icu
#5
Joshua Glazer, Richard Medlin, Benjamin Bassin, Kyle Gunnerson
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849380/combined-treatment-with-saxagliptin-plus-dapagliflozin-reduces-insulin-levels-by-increased-insulin-clearance-and-improves-%C3%AE-cell-function
#6
Ella Ekholm, Lars Hansen, Eva Johnsson, Nayyar Iqbal, Björn Carlsson, Hungta Chen, Boaz Hirshberg
OBJECTIVE: To determine if reduction in serum insulin with dapagliflozin plus saxagliptin or dapagliflozin add-on to metformin contributed to increased insulin clearance and to assess the effects of these treatments on β-cell function. METHODS: Patients (A1C 8.0%-12.0%) were randomized to 24-week, double-blind treatment with saxagliptin 5 mg/d plus dapagliflozin 10 mg/d (n=179), saxagliptin 5 mg/d plus placebo (n=176), or dapagliflozin 10 mg/d plus placebo (n=179) added to metformin...
November 16, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27810229/cumulative-effect-of-the-plasma-total-homocysteine-related-genetic-variants-on-schizophrenia-risk
#7
Makoto Kinoshita, Shusuke Numata, Atsushi Tajima, Akira Nishi, Sho Muraki, Atsushi Tsuchiya, Hidehiro Umehara, Shin-Ya Watanabe, Issei Imoto, Tetsuro Ohmori
Previous studies suggest that elevated total homocysteine levels and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, which correlates with plasma total homocysteine levels, are risk factors for schizophrenia (SCZ). Recently, a large genome-wide association study (GWAS) of plasma total homocysteine levels in individuals of European ancestry identified many single-nucleotide polymorphisms (SNPs) (n=13,974). The primary purpose of this study was to examine the association between these plasma total homocysteine-related SNPs and SCZ in the Japanese population...
October 17, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27795784/-seroprevalence-of-hbsag-in-pregnant-women-in-central-morocco
#8
Mohammed Sbiti, Hanane Khalki, Imane Benbella, Lhoussaine Louzi
Maternal-fetal transmission of hepatitis B virus (HBV) is a global public health problem leading to the implementation of strengthened prevention measures. Viral replication in HIV-positive mother, assessed based on HBeAg positivity and the rate of viral load, determines the contamination risk which is very important during perinatal period. Mothers with chronic HBV are a real reservoir of vertical transmission of this infection. This is a prospective investigation of 1120 pregnant Moroccan women aiming to study the seroprevalence of HBsAg which was 2...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27776851/optimization-of-fenton-treatment-process-for-degradation-of-refractory-organics-in-pre-coagulated-leachate-membrane-concentrates
#9
Jing Xu, Yuyang Long, Dongsheng Shen, Huajun Feng, Ting Chen
Untreated leachate membrane concentrates are a threat to the environment. In our study, effective removal of contaminants in pre-coagulated leachate membrane concentrates was achieved using the Fenton process. The Fenton process was optimized using the response surface method, and the maximum total organic carbon (TOC), chemical oxygen demand (COD), and chromaticity reduction efficiencies reached 68.9%, 69.6%, and 100% under the conditions pH 2, H2O2 concentration 1mol/L, and Fe(2+) concentration 17.5mmol/L...
February 5, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27738633/shear-bond-strength-of-three-orthodontic-bonding-systems-on-enamel-and-restorative-materials
#10
Andreas Hellak, Jennifer Ebeling, Michael Schauseil, Steffen Stein, Matthias Roggendorf, Heike Korbmacher-Steiner
Objective. The aim of this in vitro study was to determine the shear bond strength (SBS) and adhesive remnant index (ARI) score of two self-etching no-mix adhesives (iBond™ and Scotchbond™) on different prosthetic surfaces and enamel, in comparison with the commonly used total etch system Transbond XT™. Materials and Methods. A total of 270 surfaces (1 enamel and 8 restorative surfaces, n = 30) were randomly divided into three adhesive groups. In group 1 (control) brackets were bonded with Transbond XT primer...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27716819/a-phase-i-dose-escalation-study-of-the-triple-angiokinase-inhibitor-nintedanib-combined-with-low-dose-cytarabine-in-elderly-patients-with-acute-myeloid-leukemia
#11
Christoph Schliemann, Joachim Gerss, Stefanie Wiebe, Jan-Henrik Mikesch, Nicola Knoblauch, Tim Sauer, Linus Angenendt, Tobias Kewitz, Marc Urban, Trude Butterfass-Bahloul, Sabine Edemir, Kerstin Vehring, Carsten Müller-Tidow, Wolfgang E Berdel, Utz Krug
: Nintedanib (BIBF 1120), a potent multikinase inhibitor of VEGFR-1/-2/-3, FGFR-1/-2/-3 and PDGFR-α/-β, exerts growth inhibitory and pro-apoptotic effects in myeloid leukemic cells, especially when used in combination with cytarabine. This phase I study evaluated nintedanib in combination with low-dose cytarabine (LDAC) in elderly patients with untreated or relapsed/refractory acute myeloid leukemia (AML) ineligible for intensive chemotherapy in a 3+3 design. Nintedanib (dose levels 100, 150, and 200 mg orally twice daily) and LDAC (20 mg subcutaneous injection twice daily for 10 days) were administered in 28-day cycles...
2016: PloS One
https://www.readbyqxmd.com/read/27662210/il6-174-g-c-polymorphism-rs1800795-association-with-late-effects-of-low-dose-radiation-exposure-in-the-portuguese-tinea-capitis-cohort
#12
Paula Boaventura, Cecília Durães, Adélia Mendes, Natália Rios Costa, Inês Chora, Sara Ferreira, Emanuel Araújo, Pedro Lopes, Gilberto Rosa, Pedro Marques, Paulo Bettencourt, Inês Oliveira, Francisco Costa, Isabel Ramos, Maria José Teles, João Tiago Guimarães, Manuel Sobrinho-Simões, Paula Soares
Head and neck cancers, and cardiovascular disease have been described as late effects of low dose radiation (LDR) exposure, namely in tinea capitis cohorts. In addition to radiation dose, gender and younger age at exposure, the genetic background might be involved in the susceptibility to LDR late effects. The -174 G>C (rs1800795) SNP in IL6 has been associated with cancer and cardiovascular disease, nevertheless this association is still controversial. We assessed the association of the IL6-174 G>C SNP with LDR effects such as thyroid carcinoma, basal cell carcinoma and carotid atherosclerosis in the Portuguese tinea capitis cohort...
2016: PloS One
https://www.readbyqxmd.com/read/27628538/the-tetraodon-nigroviridis-reference-transcriptome-developmental-transition-length-retention-and-microsynteny-of-long-non-coding-rnas-in-a-compact-vertebrate-genome
#13
Swaraj Basu, Yavor Hadzhiev, Giuseppe Petrosino, Chirag Nepal, Jochen Gehrig, Olivier Armant, Marco Ferg, Uwe Strahle, Remo Sanges, Ferenc Müller
Pufferfish such as fugu and tetraodon carry the smallest genomes among all vertebrates and are ideal for studying genome evolution. However, comparative genomics using these species is hindered by the poor annotation of their genomes. We performed RNA sequencing during key stages of maternal to zygotic transition of Tetraodon nigroviridis and report its first developmental transcriptome. We assembled 61,033 transcripts (23,837 loci) representing 80% of the annotated gene models and 3816 novel coding transcripts from 2667 loci...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27623045/predictive-value-of-b-type-natriuretic-peptide-bnp-for-adverse-cardiac-events-in-patients-undergoing-primary-total-knee-arthroplasty-tka
#14
Gong Long, Chen Hao, Geng Li, Yu Yang, Zhou Hongzhong, Wang Zhenhu
BACKGROUND: B-type natriuretic peptide (BNP) is a well-known biomarker to predict cardiac events following orthopedic procedures. However, further information regarding BNP can be completed. The present study aims to determine which of preoperative, postoperative or the difference between them (DVPPB) can best predict adverse cardiac events following TKA procedure and detect possible risk factors of high level of BNP. METHODS: Between Jan. 2012 and Jan. 2014. 1120 included patients in 3 institutions have a minimum of 2-years follow-up...
September 9, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27620931/prevalence-of-work-site-injuries-and-relationship-between-obesity-and-injury-among-u-s-workers-nhis-2004-2012
#15
Ja K Gu, Luenda E Charles, Michael E Andrew, Claudia C Ma, Tara A Hartley, John M Violanti, Cecil M Burchfiel
INTRODUCTION: Studies have reported associations between obesity and injury in a single occupation or industry. Our study estimated the prevalence of work-site injuries and investigated the association between obesity and work-site injury in a nationally representative sample of U.S. workers. METHODS: Self-reported weight, height, and injuries within the previous three months were collected annually for U.S. workers in the National Health Interview Survey (NHIS) from 2004-2012...
September 2016: Journal of Safety Research
https://www.readbyqxmd.com/read/27602975/efinaconazole-10-and-tavaborole-5-penetrate-across-poly-ureaurethane-16-results-of-in-vitro-release-testing-and-clinical-implications-of-onychodystrophy-in-onychomycosis
#16
Chris G Adigun, Tracey C Vlahovic, Michael B McClellan, Kailas D Thakker, Ryan R Klein, Tuan A Elstrom, Daniel B Ward
BACKGROUND: Poly-ureaurethane has been previously described for the management of dry, brittle, and in general, dystrophic nails. The polymer yields a waterproof, breathable barrier to protect the nail plate and prevent further damage to the nail, while regulating transonychial water loss (TOWL). Because nail dystrophy and dessication are contributing factors to onychomycosis, a barrier that protects the nail but also allows a topical antifungal to permeate its shield is potentially an advantageous combination...
September 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27586183/characterization-and-expression-analysis-of-receptor-for-activated-c-kinase-from-silk-producing-insect-antheraea-pernyi
#17
Bao-Jian Zhu, Hao Yu, Sen Tian, Li-Shang Dai, Yu Sun, Chao-Liang Liu
The receptor for activated C kinase (RACK) is an important scaffold protein with regulatory functions in cells. However, its role in the immune response of Antheraea pernyi to pathogen challenge remains unclear. To investigate the biological functions of RACK in the wild silkworm A. pernyi, cloning was performed and the expression patterns of the RACK gene were analyzed. Sequence analysis revealed that the RACK gene was 1120 bp containing a 960-bp open reading frame. The deduced RACK protein sequence reveals the higher identity with its homologs from other insects...
2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27584276/high-intensity-interval-training-in-overweight-and-sedentary-adults-impacts-on-intention-for-future-exercise-1120-board-3-june-1-3-15-pm-5-15-pm
#18
Marcus W Kilpatrick, Shelbey E Lane, Andrew M Rice, Danielle T Aguilar, Gabrielle Kallin, Tam Tran, Kailey M Catapano, Mary E Jung
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27582286/enamel-shear-bond-strength-of-two-orthodontic-self-etching-bonding-systems-compared-to-transbond%C3%A2-xt
#19
Andreas Hellak, Patrick Rusdea, Michael Schauseil, Steffen Stein, Heike Maria Korbmacher-Steiner
OBJECTIVE: The aim of this in vitro study was to compare the shear bond strength (SBS) and Adhesive Remnant Index (ARI) scores of two self-etching no-mix adhesives (Prompt L-Pop™ and Scotchbond™) for orthodontic appliances to the commonly used total etch system Transbond XT™ (in combination with phosphoric acid). MATERIALS AND METHODS: In all, 60 human premolars were randomly divided into three groups of 20 specimens each. In group 1 (control), brackets were bonded with Transbond™ XT primer...
August 31, 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27576765/epidemiology-of-psoriatic-disease-and-current-treatment-patterns-from-2003-to-2013-a-nationwide-population-based-observational-study-in-taiwan
#20
Ting-Shun Wang, Chi-Feng Hsieh, Tsen-Fang Tsai
BACKGROUND: Recent global data show an increasing prevalence of psoriasis and psoriatic arthritis in western countries. OBJECTIVE: The current study analyzed the trend of prevalence rates of psoriasis and psoriatic arthritis in Taiwan and examined biologic prescription patterns by different specialties. METHODS: Data were accessed from the national payer National Health Insurance Research Database in Taiwan. This study protocol was approved by Joint Institutional Review Board established by Medical Research Ethics Foundation (No 13-S-001)...
December 2016: Journal of Dermatological Science
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