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Benyamin Hoseini, Nasser Bagheri, Behzad Kiani, Amirabbas Azizi, Hamed Tabesh, Mahmood Tara
Equitable access to healthcare services constitutes one of the leading priorities of healthcare provision and access to dialysis services (ADS) has an essential impact on patients depending on renal dialysis. The many existing GIS-based ADS evaluations include various spatial and non-spatial factors affecting ADS. We systematically mapped and reviewed the available literature with reference to this area identifying gaps in current GIS-based ADS measurements and developing recommendations for future studies...
May 7, 2018: Geospatial Health
John D Scott, Catherine M Scott
Human babesiosis caused by Babesia duncani is an emerging infectious disease in Canada. This malaria-like illness is brought about by a protozoan parasite infecting red blood cells. Currently, controversy surrounds which tick species are vectors of B. duncani. Since the availability of a serological or molecular test in Canada for B. duncani has been limited, we conducted a seven-year surveillance study (2011⁻2017) to ascertain the occurrence and geographic distribution of B. duncani infection country-wide...
May 17, 2018: Healthcare (Basel, Switzerland)
Zarazuela Zolkipli-Cunningham, Rui Xiao, Amy Stoddart, Elizabeth M McCormick, Amy Holberts, Natalie Burrill, Shana McCormack, Lauren Williams, Xiaoyan Wang, John L P Thompson, Marni J Falk
BACKGROUND: Clinical treatment trials are increasingly being designed in primary mitochondrial disease (PMD), a phenotypically and genetically heterogeneous collection of inherited multi- system energy deficiency disorders that lack effective therapy. We sought to identify motivating factors and barriers to clinical trial participation in PMD. METHODS: A survey study was conducted in two independent mitochondrial disease subject cohorts. A discovery cohort invited subjects with well-defined biochemical or molecularly- confirmed PMD followed at a single medical center (CHOP, n = 30/67 (45%) respondents)...
2018: PloS One
Cornelius Remschmidt, Christin Schröder, Michael Behnke, Petra Gastmeier, Christine Geffers, Tobias Siegfried Kramer
Background: Enterococci are frequent pathogens causing nosocomial infections in Germany. Infections due to strains with vancomycin resistance are high when compared with other European states. Therefore, the study aimed to describe the recent progression of nosocomial infections due to vancomycin-resistant enterococci (VRE) in Germany. Methods: We analyzed data from two components of the German national nosocomial infection surveillance system for the period 2007-2016...
2018: Antimicrobial Resistance and Infection Control
Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn, Jae Myun Lee, Tae Il Kim
PURPOSE: Several studies have reported relationships among physical activity, healthy metabolic status, and increased natural killer (NK) cell activity. However, large-scale data thereon are lacking. Thus, the present study aimed to assess NK cell activity according to physical activity and metabolic status. MATERIALS AND METHODS: A cross-sectional study was performed on 12014 asymptomatic examinees. Using a patented stimulatory cytokine, NK cell activity was quantitated by the amount of interferon-γ secreted into the plasma by NK cells...
June 2018: Yonsei Medical Journal
Pankaj Panwar, Ravimohan S Mavuduru, Uttam Kumar Mete, Santosh Kumar, Girdhar Singh Bora, Sudheer Kumar Devana, Arup Kumar Mandal, Shrawan Kumar Singh, Nandita Kakkar
Introduction: Open radical cystectomy (RC) is associated with significant morbidity and the role of minimally invasive surgery (MIS) in reducing morbidity of RC is controversial A direct comparison of various surgical modalities on perioperative outcomes is lacking in the Indian literature. We evaluated outcomes of minimally invasive (robotic and laparoscopic) versus open RC with pelvic lymph node dissection (PLND) performed at our institute from 2014 to 2016. Methods: Eighty-three patients of RC with PLND were prospectively analyzed from December 2014 to February 2016...
April 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
Steven J Fitzgerald, Terrence C Palmer, Matthew J Kraay
BACKGROUND: We developed an orthopedic hospitalist fellowship program for our total joint replacement program at a large urban academic medical center. The goal of the program was to improve patient outcomes, quality, and healthcare value through collaborative perioperative care and improved care coordination. This study evaluates the implementation and impact of our modified Hospitalist-Orthopaedic Team Co-management model on quality and performance metrics. METHODS: We reviewed our Quality Institute data using 3 databases for the 16 months before (PreOH) and 18 months after (PostOH) implementation...
March 21, 2018: Journal of Arthroplasty
Sally Rouse, Peter Hayes, Ian M Davies, Thomas A Wilding
The spatial extent of human activities must be understood for consistent and proportionate regulation, and effective marine planning. Redundant offshore pipelines can be removed or left in situ, but data on the footprint of these options are not readily available. The extents of three North Sea in situ decommissioning scenarios are presented. Leaving pipelines in situ would occupy <0.01% (12.3 km2 ) of UK waters, and this was similar to, or smaller than, other regulated activities (e.g. aggregate extraction)...
April 2018: Marine Pollution Bulletin
Clare J Lee, Todd T Brown, Michael Schweitzer, Thomas Magnuson, Jeanne M Clark
BACKGROUND: Hypoglycemia after bariatric surgery is an increasingly recognized metabolic complication associated with exaggerated secretion of insulin and gut hormones. OBJECTIVE: We sought to determine the incidence of hypoglycemic symptoms (hypo-sx) after bariatric surgery and characteristics of those affected compared with those unaffected. SETTING: University hospital. METHODS: We collected retrospective survey data from the patients who underwent bariatric surgery at a single center...
January 31, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Eun-Jung Cho, Dae-Hyun Ko, Woochang Lee, Sail Chun, Hae Kyung Lee, Won-Ki Min
BACKGROUND: The manual microscopic examination (MME) of urine sediment is labor-intensive, time-consuming, and imprecise. Therefore, automated urinalysis systems based on flow cytometry or digital imaging techniques could replace MME. The purpose of this study was to evaluate the rate of MME using two automated urine sediment analyzers, alone and in combination. METHODS: This study was conducted using the freshly collected urine specimens of 1055 in-patients and 1119 out-patients...
April 12, 2018: Clinical Biochemistry
Victor O Lasebikan, Olatunde Ayinde, Mayokun Odunleye, Babajide Adeyefa, Samson Adepoju, Shina Fakunle
BACKGROUND: There is a rapid shift in the social context of drinking, with a large proportion of regular drinkers favouring outdoor-open space drinking, such as motor-parks, by the road sides, the majority of which are unlicensed premises for drinking. METHOD: This study determined the prevalence and determinants of harmful or hazardous alcohol use and possible dependence, defined as a "likely alcohol use disorder" (AUD) in a community sample of 1119 patrons of open space drinking places in Ibadan, Nigeria, using the AUDIT...
March 27, 2018: BMC Public Health
Aneta M Białkowska, Joanna Krysiak, Tomasz Florczak, Katarzyna M Szulczewska, Marta Wanarska, Marianna Turkiewicz
A psychrotrophic yeast strain producing a cold-adapted protease at low temperature was classified as Sporobolomyces roseus. In standard YPG medium, S. roseus LOCK 1119 synthesized an extracellular protease with an activity of approx. 560 U/L. Optimization of medium composition and process temperature considerably enhanced enzyme biosynthesis; an approx. 70% increase in activity (2060 U/L). The native enzyme was purified to homogeneity by cation exchange chromatography followed by a size exclusion step, resulting in a 103-fold increase in specific activity (660 U/mg) with 25% recovery...
March 23, 2018: Biotechnology and Applied Biochemistry
Sylvia L Crowder, Katherine G Douglas, M Yanina Pepino, Kalika P Sarma, Anna E Arthur
PURPOSE: It is estimated that more than 90% of head and neck cancer (HNC) survivors who underwent chemoradiotherapy experience one or more nutrition impact symptoms (NIS) in the months or years thereafter. Despite the high prevalence, there is limited research addressing long-term impact of NIS on outcomes such as nutrition and quality of life in HNC survivors treated with chemoradiotherapy. OBJECTIVE: To conduct a systematic review of the literature pertaining to the presence of nutrition impact symptoms and their associated outcomes in post-chemoradiotherapy head and neck cancer survivors...
March 20, 2018: Journal of Cancer Survivorship: Research and Practice
Shivani Mishra, Himani Pandey, Priyanka Srivastava, Kausik Mandal, Shubha R Phadke
OBJECTIVE: To determine the prevalence and spectrum of Connexin 26 (GJB2) mutations in pre-lingual non-syndromic hearing loss (NSHL) patients in authors' centre and to review the data of Indian patients from the literature. METHODS: Sanger sequencing of entire coding region contained in single exon (Exon 2) of GJB2 gene in 15 patients of NSHL. RESULTS: GJB2 mutations were found in 40% (6/15) of NSHL patients, out of which mono-allelic were 33...
March 15, 2018: Indian Journal of Pediatrics
Elisabeth J Diver, Emily M Hinchcliff, Allison A Gockley, Alexander Melamed, Leah Contrino, Sarah Feldman, Whitfield B Growdon
OBJECTIVE: This study aims to understand the treatment patterns and clinical outcomes of older women with cervical cancer compared to younger women. METHODS: Women undergoing care for cervical cancer between 2000 and 2013 at two academic institutions were identified. The cohort of older patients was defined as >65 years old at diagnosis. Patient charts were retrospectively reviewed, and clinical variables were extracted. Fisher's exact tests, logistic regression, and Kaplan-Meier analyses were performed...
March 1, 2018: Journal of Geriatric Oncology
Adriana Lopez-Pineda, Alberto Cordero, Concepción Carratala-Munuera, Domingo Orozco-Beltran, Jose A Quesada, Vicente Bertomeu-Gonzalez, Vicente F Gil-Guillen, Vicente Bertomeu-Martinez
BACKGROUND AND AIMS: Many studies have reported the independent association between uric acid and cardiovascular disease, its role as a risk predictor for outcomes in people with acute coronary syndrome remains controversial. This study aims to assess the association between hyperuricemia and medium/long-term clinical outcomes in people with acute coronary syndrome and determine whether adding hyperuricemia to the GRACE score improves its predictive capability. METHODS: This cohort study included patients admitted for acute coronary syndrome between 2008 and 2013...
February 2018: Atherosclerosis
Marielle S Goyette, Peter M Mutiti, David Bukusi, Beatrice M Wamuti, Felix A Otieno, Peter Cherutich, Matthew R Golden, Hans Spiegel, Barbra A Richardson, Anne Ngʼangʼa, Carey Farquhar
BACKGROUND: HIV assisted partner services (APS) are a notification and testing strategy for sex partners of HIV-infected index patients. This cluster-randomized controlled trial secondary data analysis investigated whether history of intimate partner violence (IPV) modified APS effectiveness and risk of relationship dissolution. SETTING: Eighteen HIV testing and counseling sites in Kenya randomized to provide immediate APS (intervention) or APS delayed for 6 weeks (control)...
May 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Shaojun Liu, Zhiming Xiao, Feiyan Ai, Fen Liu, Xiong Chen, Ke Cao, Weiguo Ren, Xuemei Zhang, Peng Shu, Decai Zhang
No abstract text is available yet for this article.
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Chen-Chen Liu, Shusheng Ji, Yuanyuan Ding, Lili Zhou, Xiangyu Liu, Wen Li
AIMS: Many studies have suggested Cytomegalovirus infection might be implicated in steroid-refractory inflammatory bowel disease (IBD), in which situation management is extremely difficult. CMV infection being a potential cause of IBD have drawn great attention of clinicians, with insufficient evidence to reach conclusions. METHODS: We conduct this meta-analysis to explore the association of CMV infection and steroid-refractory IBD by collecting relevant articles...
February 1, 2018: Irish Journal of Medical Science
Jude Juventus Aweya, Wei Wang, Yueling Zhang, Defu Yao, Shengkang Li, Fan Wang
The Pim1 serine/threonine kinase is associated with multiple cellular functions including proliferation, survival, differentiation, apoptosis, tumorigenesis, immune regulation and inflammation in vertebrates. However, little is known about the role of Pim1 in invertebrate immunity. In this study, we identified and characterized for the first time, a Pim1 (LvPim1) gene in Litopenaeus vannamei, with a full-length cDNA of 2352 bp and a 1119 bp open reading frame (ORF) encoding a putative protein of 372 amino acids, which contains a typical serine/threonine kinase domain...
March 2018: Fish & Shellfish Immunology
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