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https://www.readbyqxmd.com/read/28923814/new-method-for-real-time-influenza-surveillance-in-primary-care-a-wisconsin-research-and-education-network-wren-supported-study
#1
Jonathan L Temte, Shari Barlow, Amber Schemmel, Emily Temte, David L Hahn, Erik Reisdorf, Peter Shult, John Tamerius
INTRODUCTION: The goal of public health infectious disease surveillance systems is to provide accurate laboratory results in near-real time. When it comes to influenza surveillance, most current systems are encumbered with inherent delays encountered in the real-life chaos of medical practice. To combat this, we implemented and tested near-real-time surveillance using a rapid influenza detection test (RIDT) coupled with immediate, wireless transmission of results to public health entities...
September 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28917449/highly-potent-antiobesity-effect-of-a-short-length-peptide-yy-analog-in-mice
#2
Naoki Nishizawa, Ayumu Niida, Yusuke Adachi, Yoko Kanematsu-Yamaki, Yasushi Masuda, Satoshi Kumano, Kotaro Yokoyama, Yoko Noguchi, Tomoko Asakawa, Hideki Hirabayashi, Nobuyuki Amano, Shiro Takekawa, Tetsuya Ohtaki, Taiji Asami
Continuous administration of a 14-amino acid peptide YY (PYY) analog, Ac-[d-Pro(24),Pya(4)(26),Cha(27,36),Aib(28,31),Lys(30)]PYY(23-36) (4), which has a high binding affinity and agonist activity for the neuropeptide Y2 receptor (Y2R), has previously shown an antiobesity effect in a 2-week diet-induced obesity (DIO) study in mice. However, there remained a possibility to obtain more potent analogs by further improving its pharmacokinetic profile. A combination of the N-terminal 4-imidazolecarbonyl moiety and three amino acid substitutions, trans-4-hydroxy-d-proline (d-Hyp)(24), isovaline (Iva)(25), and γ-methylleucine (γMeLeu)(28), not only improved the binding affinity of the peptide for Y2R but also increased its anorectic activity in lean mice...
September 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28914465/exploring-avenues-for-best-use-of-cytotechnologists-in-non-gynaecological-cytology-double-screening-or-independent-sign-out
#3
G Fischer, M Haddad, K Cormier
OBJECTIVE: Cytotechnologist (CT) screening workload has been decreasing due to the falling number of Papanicolaou tests. This continuing trend has prompted exploration of ways to best employ the CT skillset. One potential way of more effective use is by having two CTs double screen non-gynaecological (NGC) cases to assess whether this improves screening quality and concordance with pathologists. Another is evaluating the CT's performance on low-complexity negative NGC cases for a potential independent CT sign-out without pathologist review...
September 15, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28898447/complete-response-under-sorafenib-in-patients-with-hepatocellular-carcinoma-relationship-with-dermatologic-adverse-events
#4
Jordi Rimola, Álvaro Díaz-González, Anna Darnell, María Varela, Fernando Pons, Manuel Hernandez-Guerra, Manuel Delgado, Javier Castroagudin, Ana Matilla, Bruno Sangro, Carlos Rodriguez de Lope, Margarita Sala, Carmen Gonzalez, Carlos Huertas, Beatriz Minguez, Carmen Ayuso, Jordi Bruix, Maria Reig
Background-aims: The clinical benefit of sorafenib in patients with hepatocellular carcinoma (HCC) has been undervalued due to the absence of complete responses even though patients who develop early dermatologic reactions have shown very positive outcome. In addition, sorafenib is described as an antiangiogenic drug, but it also acts on immunological cells. Thus, the aim is to assess the complete response rate in a retrospective cohort of HCC patients treated with sorafenib and to describe the profile of the patients who achieve complete response for identifying factors related to this event and their connection with the immunological profile of sorafenib...
September 12, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28894394/normative-values-for-colonic-transit-time-and-patient-assessment-of-constipation-in-adults-with-functional-constipation-systematic-review-with-meta-analysis
#5
REVIEW
Larry E Miller, Alvin Ibarra, Arthur C Ouwehand
Availability of normative patient outcome data may assist in designing experiments and estimating sample sizes. The purpose of this review was to determine normative ranges for colonic transit time (CTT), Patient Assessment of Constipation-Symptoms (PAC-SYM), and Patient Assessment of Constipation-Quality of Life (PAC-QOL) in adults diagnosed with functional constipation per Rome III guidelines. Pooled estimates were derived from random-effects meta-analysis. Meta-regression was used to explore sources of heterogeneity among studies...
2017: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/28864774/negatively-charged-residues-in-the-first-extracellular-loop-of-the-l-type-cav1-2-channel-anchor-the-interaction-with-the-cav%C3%AE-2%C3%AE-1-auxiliary-subunit
#6
Benoîte Bourdin, Julie Briot, Marie-Philippe Tétreault, Rémy Sauvé, Lucie Parent
Voltage-gated L-type CaV1.2 channels in cardiomyocytes exist as heteromeric complexes. Co-expression of CaVα2δ1 with CaVβ /CaVα1 proteins reconstitutes the functional properties of native L-type currents but the interacting domains at the CaV1.2/CaVα2δ1 interface are unknown. Here, a homology-based model of CaV1.2 identified protein interfaces between the extracellular domain of CaVα2δ1 and the extracellular loops of the CaVα1 protein in repeats I (IS1S2, IS5S6), II (IIS5S6), and III (IIIS5S6). Insertion of a 9-residue hemagglutinin epitope in IS1S2, but not in IS5S6 or in IIS5S6, prevented the co-immunoprecipitation of CaV1...
September 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28844575/weight-regain-in-patients-with-symptoms-of-post-bariatric-surgery-hypoglycemia
#7
Sanskriti Varma, Jeanne M Clark, Michael Schweitzer, Thomas Magnuson, Todd T Brown, Clare J Lee
BACKGROUND: Weight regain (WR) and symptoms of post-bariatric surgery hypoglycemia (PBSH) are metabolic complications observed in a subset of postbariatric patients. Whether hypoglycemic symptoms are an important driver of increased caloric intake and WR after bariatric surgery is unknown. OBJECTIVE: This study aims to determine whether patients with PBSH symptoms have greater odds for WR. SETTING: Tertiary academic hospital. METHODS: Patients who underwent Roux-en-Y gastric bypass or sleeve gastrectomy at our tertiary academic hospital from August 2008 to August 2012 were mailed a survey, from which weight trajectory and PBSH symptoms were assessed...
June 23, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28835207/adverse-events-following-immunization-with-pentavalent-vaccine-experiences-of-newly-introduced-vaccine-in-iran
#8
Manoochehr Karami, Pegah Ameri, Jalal Bathaei, Zeinab Berangi, Tahereh Pashaei, Ali Zahiri, Seyed Mohsen Zahraei, Hussein Erfani, Koen Ponnet
BACKGROUND: The most important factors that affect the incidence of vaccine-related complications are the constituent biological components of the vaccine, injection site reactions, age and sex. The aim of this study is to determine the incidence rate of adverse events following immunization with pentavalent vaccine (DTPw-Hep B-Hib (PRP-T) vaccine (pentavac) (adsorbed) is manufactured by Serum Institute of India ltd), which was introduced in Iran in November 2014. It is important to monitor vaccine-related adverse events because of the role of vaccine safety in immunization program success...
August 23, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28821510/social-and-somatic-determinants-of-underweight-overweight-and-obesity-at-5-years-of-age-a-norwegian-regional-cohort-study
#9
Hilde Mjell Donkor, Jacob Holter Grundt, Pétur Benedikt Júlíusson, Geir Egil Eide, Jørgen Hurum, Robert Bjerknes, Trond Markestad
OBJECTIVE: To identify associations between the weight groups underweight (UW), overweight (OW) and obesity (OB) at 5 years of age and exposures related to pregnancy, anthropometric measures at birth, sociodemographic factors, and family health, anthropometric measures and habits. DESIGN: Regional cohort study. SETTING: Oppland County, Norway. METHODS: Pregnancy data were obtained from a prospective perinatal register for children born in the county, and weight and height were measured by midwives at birth and by public health nurses at 5 years...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28820889/altered-fetal-growth-placental-abnormalities-and-stillbirth
#10
Radek Bukowski, Nellie I Hansen, Halit Pinar, Marian Willinger, Uma M Reddy, Corette B Parker, Robert M Silver, Donald J Dudley, Barbara J Stoll, George R Saade, Matthew A Koch, Carol Hogue, Michael W Varner, Deborah L Conway, Donald Coustan, Robert L Goldenberg
BACKGROUND: Worldwide, stillbirth is one of the leading causes of death. Altered fetal growth and placental abnormalities are the strongest and most prevalent known risk factors for stillbirth. The aim of this study was to identify patterns of association between placental abnormalities, fetal growth, and stillbirth. METHODS AND FINDINGS: Population-based case-control study of all stillbirths and a representative sample of live births in 59 hospitals in 5 geographic areas in the U...
2017: PloS One
https://www.readbyqxmd.com/read/28791991/erratum-complications-of-arteriovenous-fistula-with-polytetraflouroethylen-grafts-in-hemodialysis-patients
#11
(no author information available yet)
[This corrects the article DOI: 10.4103/1119-3077.146993.].
July 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28770545/how-to-reduce-cisatracurium-consumption-in-ards-patients-the-tof-ards-study
#12
Sami Hraiech, Jean-Marie Forel, Christophe Guervilly, Romain Rambaud, Samuel Lehingue, Mélanie Adda, Pierre Sylla, Sabine Valera, Julien Carvelli, Marc Gainnier, Laurent Papazian, Jérémy Bourenne
BACKGROUND: Neuromuscular blocking agents (NMBAs) have been shown to improve the outcome of the most severely hypoxemic, acute respiratory distress syndrome (ARDS) patients. However, the recommended dosage as well as the necessity of monitoring the neuromuscular block is unknown. We aimed to evaluate the efficiency of a nurse-directed protocol of NMBA administration based on a train-of-four (TOF) assessment to ensure a profound neuromuscular block and decrease cisatracurium consumption compared to an elevated and constant dose regimen...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28738092/the-efficacy-of-jianpi-yiqi-therapy-for-chronic-atrophic-gastritis-a-systematic-review-and-meta-analysis
#13
Yun-Kai Dai, Yun-Zhan Zhang, Dan-Yan Li, Jin-Tong Ye, Ling-Feng Zeng, Qi Wang, Ling Hu
Jianpi Yiqi therapy (JYT) is a classical therapy in treating chronic atrophic gastritis (CAG), but the clinical effects of it are still contentious. The purpose of this article is to evaluate the efficacy and safety of JYT for CAG. Seven electronic databases including PubMed, Embase, Springer Link, CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientific Journals Database), Wan-fang database, and CBM (Chinese Biomedicine Database) were searched from their inception to November 1, 2016. 13 randomized controlled trials (RCTs) with a total of 1119 participants were identified for analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28701292/short-text-messages-to-encourage-adherence-to-medication-and-follow-up-for-people-with-psychosis-mobile-net-randomized-controlled-trial-in-finland
#14
Maritta Välimäki, Kati Anneli Kannisto, Tero Vahlberg, Heli Hätönen, Clive E Adams
BACKGROUND: A text messaging service (short message service [SMS]) has the potential to target large groups of people with long-term illnesses such as serious mental disorders, who may have difficulty with treatment adherence. Robust research on the impact of mobile technology interventions for these patients remains scarce. OBJECTIVE: The main objective of our study was to investigate the impact of individually tailored short text messages on the rate of psychiatric hospital readmissions, health care service use, and clinical outcomes...
July 12, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28686647/diagnostic-accuracy-of-elisa-for-detecting-serum-midkine-in-cancer-patients
#15
Xuan Jing, Xiangrong Cui, Hongping Liang, Chonghua Hao, Chongyang Han
Midkine (MK) has been reported as the potential novel diagnostic biomarker for cancer in several studies, but their results were controversial. Therefore, we performed a diagnostic meta-analysis to assess the diagnostic value of serum MK in cancer patients. A systematic electronic and manual search was performed for relevant literatures through several databases up to June 1, 2017. The quality of the studies included in the meta-analysis was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool...
2017: PloS One
https://www.readbyqxmd.com/read/28686483/elevated-resting-heart-rate-is-associated-with-the-severity-of-coronary-artery-disease-in-non-treated-patients-who-underwent-coronary-angiography-potential-role-of-lipoprotein-subfractions
#16
Yan Zhang, Na-Qiong Wu, Rui-Xia Xu, Sha Li, Cheng-Gang Zhu, Yuan-Lin Guo, Ying Gao, Ping Qing, Chuan-Jue Cui, Jing Sun, Jian-Jun Li
OBJECTIVE: To assess the association between resting heart rate (RHR) and lipoprotein subfractions to provide potential evidence for the relationship between RHR and severity of CAD. METHODS: A total of 1119 consecutive non-treated subjects scheduled for coronary angiography were enrolled. High-density lipoprotein (HDL) and low-density lipoprotein (LDL) separation were performed by Lipoprint System. The link of RHR with lipoprotein subfractions was assessed. RESULTS: Increased RHR was significantly associated with higher triglyceride, total cholesterol, non-HDL-cholesterol, and apolipoprotein B (all p < ...
July 7, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28670770/are-drowned-donors-marginal-donors-a-single-pediatric-center-experience
#17
Kayla R Kumm, N Thao N Galván, Sarah Koohmaraie, Abbas Rana, Michael Kueht, Katherine Baugh, Liu Hao, Dor Yoeli, Ronald Cotton, Christine A O'Mahony, John A Goss
Drowning, a common cause of death in the pediatric population, is a potentially large donor pool for OLT. Anecdotally, transplant centers have deemed these organs high risk over concerns for infection and graft dysfunction. We theorized drowned donor liver allografts do not portend worse outcomes and therefore should not be excluded from the donation pool. We reviewed our single-center experience of pediatric OLTs between 1988 and 2015 and identified 33 drowned donor recipients. These OLTs were matched 1:2 to head trauma donor OLTs from our center...
September 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28656937/erratum-prevalence-of-depression-among-health-workers-in-enugu-south-east-nigeria
#18
(no author information available yet)
[This corrects the article DOI: 10.4103/1119-3077.151726.].
June 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28631387/umeclidinium-bromide-versus-placebo-for-people-with-chronic-obstructive-pulmonary-disease-copd
#19
REVIEW
Han Ni, Aung Htet, Soe Moe
BACKGROUND: People with chronic obstructive pulmonary disease (COPD) have poor quality of life, reduced survival, and accelerated decline in lung function, especially associated with acute exacerbations, leading to high healthcare costs. Long-acting bronchodilators are the mainstay of treatment for symptomatic improvement, and umeclidinium is one of the new long-acting muscarinic antagonists approved for treatment of patients with stable COPD. OBJECTIVES: To assess the efficacy and safety of umeclidinium bromide versus placebo for people with stable COPD...
June 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28607384/peptide-specific-monoclonal-antibodies-of-leptospiral-liga-for-acute-diagnosis-of-leptospirosis
#20
Murugesan Kanagavel, Santhanam Shanmughapriya, Kayanam Vijaya Lalitha Aishwarya, Karuppiah Ponmurugan, Kasi Murugan, Naif Abdullah Al-Dhabi, Kalimuthusamy Natarajaseenivasan
Leptospirosis is underdiagnosed due to low sensitivity, need of specialised equipment, and expensive reagents for serological and molecular diagnosis respectively. Considering the sensitivity, rapidity, inexpensive reagents and collection of clinical samples, the monoclonal antibody based antigen detection method from urine samples has been developed and evaluated. LigA (LK90) based B-cell specific epitopes were predicted and synthesised as peptides for the production of monoclonal antibody. LK90543: SNAQKNQGNA (amino acids: 543 to 552), and LK901110: DHHTQSSYTP (amino acids: 1110 to 1119) with VaxiJen score of 1...
June 12, 2017: Scientific Reports
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