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REVIEW
Archana Mishra, Rituparna Maiti, Biswa Ranjan Mishra, Anand Srinivasan
Clozapine is the only approved drug for treatment-resistant schizophrenia, but the response to the drug is often inadequate. Augmentation with other antipsychotics, anticonvulsants, and antidepressants is recommended for such patients, but there is a lack of evidence regarding the most effective therapy. This network meta-analysis was conducted to evaluate the efficacy of pharmacological agents used in the augmentation strategies in patients who were partial/ non-responders to clozapine. Relevant data were extracted from 30 randomized controlled trials through searches of electronic databases (MEDLINE/PubMed, Embase, Cochrane, clinical trial registries)...
May 31, 2024: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
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JOURNAL ARTICLE
Wei-Lun Chang, Ying-Fan Chen, Yu-Hsuan Lee, Ming-Neng Shiu, Po-Yin Chang, Chao-Yu Guo, Chi-Jung Huang, Chern-En Chiang, Chen-Huan Chen, Shao-Yuan Chuang, Hao-Min Cheng
BACKGROUND: The prognosis of high or markedly low diastolic blood pressure (DBP) with normalized on-treatment systolic blood pressure on major adverse cardiovascular events (MACEs) is uncertain. This study examined whether treated isolated diastolic hypertension (IDH) and treated isolated low DBP (ILDBP) were associated with MACEs in patients with hypertension. METHODS AND RESULTS: A total of 7582 patients with on-treatment systolic blood pressure <130 mm Hg from SPRINT (Systolic Blood Pressure Intervention Trial) were categorized on the basis of average DBP: <60 mm Hg (n=1031; treated ILDBP), 60 to 79 mm Hg (n=5432), ≥80 mm Hg (n=1119; treated IDH)...
April 12, 2024: Journal of the American Heart Association
#3
JOURNAL ARTICLE
Fan Huang, Chuan Ming, Yuqian Jiang, Chenli Li, Cheng Tan
INTRODUCTION: To identify the differentially expressed genes of acute myeloid leukaemia (AML) and construct and verify a survival prognosis model combined with patient survival information. METHODS: The TARGET database was searched to identify differentially expressed peripheral blood genes in children with AML and healthy children. A gene set functional analysis and pathway analysis were performed using gene ontology and the KEGG pathway. A prognostic model for children with AML was constructed using univariate Cox, LASSO Cox regression and multivariate Cox regression analyses...
April 10, 2024: International Journal of Laboratory Hematology
#4
JOURNAL ARTICLE
Beth L Dumont, Daniel M Gatti, Mallory A Ballinger, Dana Lin, Megan Phifer-Rixey, Michael J Sheehan, Taichi A Suzuki, Lydia K Wooldridge, Hilda Opoku Frempong, Raman Akinyanju Lawal, Gary A Churchill, Cathleen Lutz, Nadia Rosenthal, Jacqueline K White, Michael W Nachman
The laboratory mouse has served as the premier animal model system for both basic and preclinical investigations for over a century. However, laboratory mice capture only a subset of the genetic variation found in wild mouse populations, ultimately limiting the potential of classical inbred strains to uncover phenotype-associated variants and pathways. Wild mouse populations are reservoirs of genetic diversity that could facilitate the discovery of new functional and disease-associated alleles, but the scarcity of commercially available, well-characterized wild mouse strains limits their broader adoption in biomedical research...
April 10, 2024: PLoS Genetics
#5
REVIEW
Elisha Deegan, Peter Lewis, Nathan J Wilson, Laynie H Pullin
PURPOSE: To explore literature, policies or procedures available to care providers on how to deliver CPR and BLS to people with a disability, for whom the current standard guidelines are not fit for purpose. MATERIAL AND METHODS: A scoping review was conducted using four databases, namely, CINHAL, PubMed, Scopus, Medline and Google Scholar. Keywords used included, disab*, wheelchairs, cardiopulmonary, resuscitation, "basic life support", life support care, and bystander CPR...
April 9, 2024: Disability and Rehabilitation
#6
REVIEW
Jumanah S Alawfi, Reem M Ragea, Sadeem S Alrubaian
Patients with cancer are at risk of malnutrition because of reduced food intake, thus making oral intake challenging. Thus, nutritional support is used to provide the nutrient requirements. Feeding tube site implantation among patients with cancer has been reported after endoscopic feeding gastrostomy installation. This manuscript aims to further explore this phenomenon using a structured database review. Among 33 seeding cases included in this review, case reports (70 %) were the most common study design, predominantly using percutaneous endoscopic gastrostomy via the pull method...
March 22, 2024: Hematology/oncology and Stem Cell Therapy
#7
JOURNAL ARTICLE
Ian O Cook, Susan Y Green, Kimberly R Rebello, Qianzi Zhang, Veronica A Glover, Rodrigo Zea-Vera, Marc R Moon, Scott A LeMaire, Joseph S Coselli
OBJECTIVE: Aortic dissection is common in patients undergoing open surgical repair of thoracoabdominal aortic aneurysm (TAAA). Most often, dissection is chronic and is associated with progressive aortic dilatation. Because contemporary outcomes in chronic dissection are not clearly understood, we compared patient characteristics and outcomes after open TAAA repair between patients with chronic dissection and those with non-dissection aneurysm. METHODS: We retrospectively analyzed data from 3470 open TAAA repairs performed in a single practice...
March 25, 2024: Journal of Vascular Surgery
#8
JOURNAL ARTICLE
Shunsuke Ikuma, Jun Akatsuka, Hayato Takeda, Yuki Endo, Tomonari Kiriyama, Tsutomu Hamasaki, Go Kimura, Yukihiro Kondo
BACKGROUND: The Vesical Imaging Reporting and Data System (VI-RADS) is widely used for predicting muscle-invasive bladder cancer (MIBC). This study aimed to determine the clinicopathological significance of the VI-RADS ≧4 (VI≧4) group. METHODS: Patients who underwent transurethral resections of bladder tumors during the study period and preoperative magnetic resonance imaging were considered. The patients were pathologically diagnosed with urothelial carcinoma (UC)...
March 20, 2024: BMC Urology
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JOURNAL ARTICLE
Kaisu Lankinen, Jyrki Ahveninen, Mainak Jas, Tommi Raij, Seppo P Ahlfors
Previous studies have demonstrated that auditory cortex activity can be influenced by cross-sensory visual inputs. Intracortical laminar recordings in non-human primates have suggested a feedforward (FF) type profile for auditory evoked but feedback (FB) type for visual evoked activity in the auditory cortex. To test whether cross-sensory visual evoked activity in the auditory cortex is associated with FB inputs also in humans, we analyzed magnetoencephalography (MEG) responses from eight human subjects (six females) evoked by simple auditory or visual stimuli...
March 20, 2024: Journal of Neuroscience
#10
MULTICENTER STUDY
Harold Duarte, Adrienne Stolfi, Courtney McCall, Shehzad Saeed, Kelly Sandberg
OBJECTIVES: This study aims to characterize pediatric inflammatory bowel disease (IBD) patients who change diagnosis and describe the characteristics of that change. METHODS: A retrospective study was conducted on pediatric IBD patients from the ImproveCareNow (ICN) multicenter international cohort from 2007 to January 2019. Primary outcome was change in diagnosis after the first four visits. Other variables included demographics, diagnostics, disease characteristics, and timing...
March 2024: Journal of Pediatric Gastroenterology and Nutrition
#11
JOURNAL ARTICLE
Haitao Wang, Wei Deng, Yang Zhang, Jinxiu Yang, Zhen Wang, Bin Liu, Yuchi Han, Yongqiang Yu, Ren Zhao, Xiaohu Li
AIM: To evaluate the subclinical cardiac involvement in COVID-19 patients without clinical cardiac evidence using cardiac MR imaging. MATERIAL AND METHODS: Participants recovered from COVID-19 without cardiac symptoms and no cardiovascular medical history were enrolled in a prospective cohort study. They underwent baseline cardiac MR and follow-up cardiac MR > 300 days after discharge (n = 20). The study also included healthy controls (n = 20)...
March 15, 2024: Heliyon
#12
RANDOMIZED CONTROLLED TRIAL
Youlia M Kirova, Pierre Loap
No abstract text is available yet for this article.
April 1, 2024: International Journal of Radiation Oncology, Biology, Physics
#13
JOURNAL ARTICLE
Shuhei Ohyama, Satoshi Maki, Toshiaki Kotani, Yosuke Ogata, Tsuyoshi Sakuma, Yasushi Iijima, Tsutomu Akazawa, Kazuhide Inage, Yasuhiro Shiga, Masahiro Inoue, Takahito Arai, Noriyasu Toshi, Soichiro Tokeshi, Kohei Okuyama, Susumu Tashiro, Noritaka Suzuki, Yawara Eguchi, Sumihisa Orita, Shohei Minami, Seiji Ohtori
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To develop a machine learning (ML) model that predicts the progression of AIS using minimal radiographs and simple questionnaires during the first visit. SUMMARY OF BACKGROUND DATA: Several factors are associated with angle progression in patients with AIS. However, it is challenging to predict angular progression at the first visit. METHODS: Among female patients with AIS treated at a single institution from July 2011 to February 2023, 1119 cases were studied...
March 13, 2024: Spine
#14
JOURNAL ARTICLE
J Qi, T J Wang, M N Wang, L X Shang, L Chen, X F Wang, Y H Li, H Xu, C F Ma
Objective: To evaluate the risk prediction and assessment function of HLA-DPB1 T-cell epitope (TCE) model and expression model in human leukocyte antigen (HLA)-matched unrelated hematopoietic stem cell transplantation (MUD-HSCT) with HLA-DPB1 mismatching. Methods: A total of 364 (182 pairs) potential MUD-HSCT donors and recipients confirmed by HLA high-resolution typing in Shaanxi Blood Center from 2016 to 2019 were analyzed retrospectively. Of the 182 recipients, there were 121 males and 61 females with an average age of (26...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
#15
JOURNAL ARTICLE
Ersilia M DeFilippis, Benjamin Sweigart, Kiran K Khush, Palak Shah, Sean Agbor-Enoh, Hannah A Valantine, Amanda R Vest
INTRODUCTION: Non-invasive methods for surveillance of acute rejection are increasingly used in heart transplantation (HT), including donor-derived cell-free DNA (dd-cfDNA). As other cardiac biomarkers differ by sex, we hypothesized that there may be sex-specific differences in performance of dd-cfDNA for detection of acute rejection. The purpose of the current study was to examine patterns of dd-cfDNA seen in quiescence and acute rejection in males and female transplant recipients. METHODS: Patients enrolled in the Genomic Research Alliance for Transplantation (GRAfT) who were ≥18 years at the time of HT were included...
March 7, 2024: Journal of Heart and Lung Transplantation
#16
JOURNAL ARTICLE
Heng-Chih Pan, Hsing-Yu Chen, Nai-Chi Teng, Fang-Yu Yeh, Tao-Min Huang, Chun Yin See, Chiao-Yin Sun, Yung-Chang Chen, Likwang Chen, Vin-Cent Wu
IMPORTANCE: The interplay among baseline kidney function, severity of acute kidney disease (AKD), and post-AKD kidney function has significant associations with patient outcomes. However, a comprehensive understanding of how these factors are collectively associated with mortality, major adverse cardiac events (MACEs), and end-stage kidney disease (ESKD) in patients with dialysis-requiring acute kidney injury (AKI-D) is yet to be fully explored. OBJECTIVE: To investigate the associations of baseline kidney function, AKD severity, and post-AKD kidney function with mortality, MACEs, and ESKD in patients with AKI-D...
March 4, 2024: JAMA Network Open
#17
JOURNAL ARTICLE
Jiasi Hao, Natalia Tiles-Sar, Tesfa Dejenie Habtewold, Edith J Liemburg, Richard Bruggeman, Lisette van der Meer, Behrooz Z Alizadeh
PURPOSE: We aimed to explore the multidimensional nature of social inclusion (mSI) among patients diagnosed with schizophrenia spectrum disorder (SSD), and to identify the predictors of 3-year mSI and the mSI prediction using traditional and data-driven approaches. METHODS: We used the baseline and 3-year follow-up data of 1119 patients from the Genetic Risk and Outcome in Psychosis (GROUP) cohort in the Netherlands. The outcome mSI was defined as clusters derived from combined analyses of thirteen subscales from the Social Functioning Scale and the brief version of World Health Organization Quality of Life questionnaires through K-means clustering...
March 8, 2024: Social Psychiatry and Psychiatric Epidemiology
#18
JOURNAL ARTICLE
Xiaohui Lin, Aoife A Gowen, Shuai Chen, Jun-Li Xu
The use of plastic bakeware is a potential source of human exposure to microplastics (MPs). However, characterizing MPs remains a challenge. This study aims to employ optical photothermal infrared (O-PTIR) and quantum cascade laser infrared (QCL-IR) technology to characterise polyethylene terephthalate (PET) MPs shed from PET bakeware during the baking process. The bakeware, filled with ultrapure water, underwent baking cycles at 220 °C for 20 min, 60 min, and three consecutive cycles of 60 min each...
March 1, 2024: Science of the Total Environment
#19
JOURNAL ARTICLE
Emily Harris
No abstract text is available yet for this article.
February 28, 2024: JAMA
#20
JOURNAL ARTICLE
Richard Drexler, Franz L Ricklefs, Sharona Ben-Haim, Anna Rada, Friedrich Wörmann, Thomas Cloppenborg, Christian G Bien, Matthias Simon, Thilo Kalbhenn, Albert Colon, Kim Rijkers, Olaf Schijns, Valeri Borger, Rainer Surges, Hartmut Vatter, Michele Rizzi, Marco de Curtis, Giuseppe Didato, Nicoló Castelli, Alexandre Carpentier, Bertrand Mathon, Clarissa Lin Yasuda, Fernando Cendes, Poodipedi Sarat Chandra, Manjari Tripathi, Hans Clusmann, Daniel Delev, Marc Guenot, Claire Haegelen, Hélène Catenoix, Johannes Lang, Hajo Hamer, Sebastian Brandner, Katrin Walther, Jason S Hauptmann, Rosalind L Jeffree, Josua Kegele, Eliane Weinbrenner, Georgios Naros, Julia Velz, Niklaus Krayenbühl, Julia Onken, Ulf C Schneider, Martin Holtkamp, Karl Rössler, Andrea Spyrantis, Adam Strzelczyk, Felix Rosenow, Stefan Stodieck, Mario A Alonso-Vanegas, Jörg Wellmer, Tim Wehner, Lasse Dührsen, Jens Gempt, Thomas Sauvigny
OBJECTIVE: Benchmarking has been proposed to reflect surgical quality and represents the highest standard reference values for desirable results. We sought to determine benchmark outcomes in patients after surgery for drug-resistant mesial temporal lobe epilepsy (MTLE). METHODS: This retrospective multicenter study included patients who underwent MTLE surgery at 19 expert centers on five continents. Benchmarks were defined for 15 endpoints covering surgery and epilepsy outcome at discharge, 1 year after surgery, and the last available follow-up...
February 24, 2024: Epilepsia
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