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https://www.readbyqxmd.com/read/29140154/no-difference-in-young-adult-athletes-resting-energy-expenditure-when-measured-under-inpatient-or-outpatient-conditions
#1
Julia L Bone, Louise M Burke
Low energy availability can place athletes at increased risk of injury and illness and can be detected by a low metabolic rate. The lowest metabolic rate is captured at the bedside, after an overnight fast and termed inpatient REE. Measurements done in a laboratory with a shorter overnight fast are termed outpatient REE. Although important to know what the lowest energy expenditure, a bedside measure and/or 12 h fast is not always practical or logistically possible particularly when you take into account an athlete's training schedule...
November 15, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29138760/cardiac-surgery-after-heart-transplantation-elective-operation-or-last-exit-strategy
#2
Johannes Goekler, Andreas Zuckermann, Emilio Osorio, Faris F Brkic, Keziban Uyanik-Uenal, Guenther Laufer, Arezu Aliabadi-Zuckermann
Background: Because of improved long-term survival after heart transplantation (HTx), late graft pathologies such as valvular disease or cardiac allograft vasculopathy (CAV) might need surgical intervention to enhance longer survival and ensure quality of life. To this date, there exist no guidelines for indication of cardiac surgery other than retransplantation after HTx. Methods: In this retrospective, single-center study, we evaluated patients who underwent cardiac surgery after HTx at our institution...
October 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29124996/a-30-year-mortality-and-respiratory-morbidity-study-of-refractory-ceramic-fiber-workers
#3
Grace LeMasters, James E Lockey, Timothy J Hilbert, Linda S Levin, Jeff W Burkle, Ralph Shipley, Charles Perme, Cristopher A Meyer, Carol H Rice
AIM: Report mortality (n = 1119), cancer incidence (n = 1207) and radiographic (n = 1451) findings from a 30-year investigation of current and former refractory ceramic fiber (RCF) workers. METHODS: Cause of death, health and work histories, radiographs and spirometry were collected. Mortality and cancer incidence were analyzed. Logistic regression analysis investigated the associations of latency and cumulative fiber exposure (CFE) on radiographic changes...
August 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29103737/synchronous-bilateral-tonsillar-carcinomas-patient-characteristics-and-human-papillomavirus-genotypes
#4
Camelia Nami Saber, Christian Grønhøj, David Hebbelstrup Jensen, Cecilie Nørregaard, Amanda Carlander, Emilie Garnæs, Katalin Kiss, Lena Specht, Christian von Buchwald
INTRODUCTION: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing, but data on the incidence of synchronous, bilateral tonsillar squamous cell carcinomas (BiTSCCs) is sparse. In this study, we report the incidence and tumour characteristics of BiTSCCs in a population-based, consecutive cohort of OPSCCs. METHODS: We identified all patients diagnosed with tonsillar squamous cell carcinoma (TSCC) in eastern Denmark during a 15-year period to detect the incidence of synchronous BiTSCCs...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29095536/increased-serum-cortisol-levels-on-oral-food-challenge-in-infants-with-fpies
#5
Masaki Shimomura, Yasunori Ito, Hiroki Tanaka, Takaaki Meguro, Mitsuaki Kimura
BACKGROUND: An increase in absolute neutrophil count (ANC) is seen after an oral food challenge test (OFC) in patients with food protein-induced enterocolitis syndrome (FPIES). Although it has been suggested that interleukin (IL)-8 is involved in this phenomenon, a possible role for cortisol has not yet been studied. METHODS: Six OFCs with positive responses in 5 patients with FPIES due to cows' milk (CM) proteins and 2 OFCs with negative responses in 2 patients suspected of FPIES were analyzed...
November 2, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29094339/prospective-study-on-long-term-outcome-after-abdominal-surgery
#6
E D Brynjarsdottir, M I Sigurdsson, E Sigmundsdottir, P H Möller, G H Sigurdsson
BACKGROUND: Complications following major abdominal surgery are common and an important cause of morbidity and mortality. The aim of this study was to describe 1-year mortality and identify factors that influence adverse outcomes after abdominal surgery. METHODS: This prospective observational cohort study was performed in Landspitali University Hospital and included all adult patients undergoing abdominal surgery requiring > 24-h hospital admission over 13 months...
November 1, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29082809/suitability-of-random-forest-analysis-for-epidemiological-research-exploring-sociodemographic-and-lifestyle-related-risk-factors-of-overweight-in-a-cross-sectional-design
#7
Noora Kanerva, Jukka Kontto, Maijaliisa Erkkola, Jaakko Nevalainen, Satu Männistö
AIMS: Factors that contribute to the development of overweight are numerous and form a complex structure with many unknown interactions and associations. We aimed to explore this structure (i.e. the mutual importance or hierarchy of sociodemographic and lifestyle-related risk factors of being overweight) using a machine-learning technique called random forest (RF). The results were compared with traditional logistic regression (LR) analysis. METHODS: The cross-sectional FINRISK 2007 Study included 4757 Finns (aged 25-74 years)...
October 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29074222/tumor-volume-on-biopsy-in-low-risk-prostate-cancers-managed-on-active-surveillance
#8
Jeffrey J Tosoian, Mufaddal Mamawala, Hiten D Patel, Ridwan Alam, Jonathan I Epstein, Ashley E Ross, H Ballentine Carter
INTRODUCTION: Contemporary clinical guidelines recommend use of active surveillance (AS) in men with low-risk prostate cancer. Low-risk disease spans any potential volume of Gleason score 6 cancer without sufficient attention to tumor volume in the past. We therefore compared tumor characteristics in low-risk men managed on AS to men undergoing RP. METHODS: We evaluated an institutional cohort of 1633 men with very low-risk (clinical stage=T1c, PSA density<0...
October 23, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29073584/vismodegib-in-patients-with-advanced-basal-cell-carcinoma-primary-analysis-of-stevie-an-international-open-label-trial
#9
N Basset-Séguin, A Hauschild, R Kunstfeld, J Grob, B Dréno, L Mortier, P A Ascierto, L Licitra, C Dutriaux, L Thomas, N Meyer, B Guillot, R Dummer, P Arenberger, K Fife, A Raimundo, E Dika, N Dimier, A Fittipaldo, I Xynos, J Hansson
BACKGROUND: The SafeTy Events in VIsmodEgib study (STEVIE, ClinicalTrials.gov, NCT01367665), assessed safety and efficacy of vismodegib-a first-in-class Hedgehog pathway inhibitor demonstrating clinical benefit in advanced basal cell carcinoma (BCC)-in a patient population representative of clinical practice. Primary analysis data are presented. PATIENTS AND METHODS: Patients with locally advanced or metastatic BCC received oral vismodegib 150 mg/d until progressive disease, unacceptable toxicity, or withdrawal...
November 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29067262/physical-inactivity-and-cardiac-events-an-analysis-of-the-detection-of-ischemia-in-asymptomatic-diabetics-diad-study
#10
Margaret M McCarthy, Frans J Th Wackers, Janice Davey, Deborah A Chyun
AIMS: Diabetes affects 29 million adults, and the majority have type 2 diabetes (T2D). Coronary artery disease (CAD) is the leading cause of death, and physical inactivity is an important risk factor. The aims of this study were to examine the contribution of physical inactivity to CAD events, and to identify the independent predictors of CAD events in a sample of older adults with T2D. METHOD: A secondary data analysis of the prospective randomized screening trial "Detection of Ischemia in Asymptomatic Diabetics (DIAD)" study...
September 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29048369/effect-of-curcumin-on-the-diversity-of-gut-microbiota-in-ovariectomized-rats
#11
Zhiguo Zhang, Yanjing Chen, Lihua Xiang, Zhen Wang, Gary Guishan Xiao, Jingqing Hu
Curcumin has been proven to have a weight-loss effect in a menopausal rat model induced by ovariectomy. However, the effects of curcumin on gut microfloral communities of ovariectomized (OVX) rats remains unclear. Here, we used high-throughput 16S rDNA sequencing to explore the effects of curcumin on microbial diversity in the gut of OVX rats. Female Wistar rats were subjected to either ovariectomy or a sham operation (SHAM group). The OVX rats were treated with vehicle (OVX group) or curcumin (CUR group) by oral gavage...
October 19, 2017: Nutrients
https://www.readbyqxmd.com/read/29045258/early-behavioral-risks-of-childhood-and-adolescent-daytime-urinary-incontinence-and-nocturnal-enuresis
#12
Monica M A Vasconcelos, Patricia East, Estela Blanco, Emily S Lukacz, Gabriela Caballero, Betsy Lozoff, Sheila Gahagan
OBJECTIVE: To investigate whether infant temperament and childhood internalizing, externalizing, and inattention symptoms increase the likelihood of daytime urinary incontinence or nocturnal enuresis at 10 years and adolescence (11.9-17.8 years). METHOD: Data were from a longitudinal cohort of 1119 healthy Chilean children. We assessed behavioral symptoms at infancy, 5 years, and 10 years and their relationship with subsequent daytime urinary incontinence and nocturnal enuresis...
November 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29030727/-parenteral-nutrition-in-premature-babies-with-a-birth-weight-1500g-a%C3%A2-systematic-single-center-analysis-and-comparison-with-current-guidelines
#13
Melanie Sirch, Martin Poryo, Mona Butte, Ulrike Lindner, Ludwig Gortner, Michael Zemlin, Holger Nunold, Sascha Meyer
BACKGROUND: Parenteral and enteral nutrition are essential for both growth and development of preterm infants. Based on the results of many studies, the rate of nutritional growth and the amount of substrate delivered parenterally are under debate. OBJECTIVE: The main aim of this study was to assess parenteral nutrition in very and extremely immature preterm infants, i.e. very low birth weight (VLBW, birth weight <1500g) and extremely low birth weight (ELBW, birth weight <1000g) neonates, and to compare the amount of parenterally delivered substrate in our neonatal intensive care unit (NICU) to current German guidelines...
October 13, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29022830/direct-costs-for-nonsurgical-management-of-chronic-pancreatitis-in-a-tertiary-care-teaching-hospital
#14
Nagesh Kamat, Ganesh Pai, Surulivel Rajan Mallayasamy, Asha Kamath, Rajasulochana S
BACKGROUND: Chronic pancreatitis (CP) is a leading cause of hospitalization among gastrointestinal diseases resulting in considerable financial burden to patients. However the direct costs for nonsurgical management in CP remains unexplored. METHODS: A cross sectional study was carried out (2011-14) in the Department of Gastroenterology, Kasturba Hospital, Manipal, India. Demographic and clinical data on laboratory investigations, interventions and follow up were obtained from the medical records department...
October 12, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28984067/resistance-characterization-of-ledipasvir-and-velpatasvir-in-hepatitis-c-virus-genotype-4
#15
Gregory Camus, Bin Han, Tarik Asselah, David Hsieh, Hadas Dvory-Sobol, Julia Lu, Evguenia Svarovskaia, Ross Martin, Bandita Parhy, Michael Miller, Diana M Brainard, Kathryn Kersey, Armand Abergel, Hongmei Mo
HCV genotype 4 (GT4) has often been overlooked in drug development, even though it infects approximately 20 million people worldwide. Ledipasvir/sofosbuvir and sofosbuvir/velpatasvir were highly efficacious in GT4 HCV infected patients from GS-US-337-1119 and GS-US-342-1138. Here we characterize the resistance profile of ledipasvir (LDV) and velpatasvir (VEL) in patients with GT4 HCV infection. NS5A deep-sequencing was performed for 454 patients infected with HCV GT4 at baseline, including 44 patients enrolled in GS-US-337-1119 and 116 patients enrolled in GS-US-342-1138, and at relapse for patients with virologic failure...
October 6, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28965811/frequent-users-of-mental-health-liaison-services-within-emergency-departments
#16
Alison Beck, Emma Sanchez-Walker, Lauren J Evans, Victoria Harris, Ruth Pegler, Sean Cross
This study aimed to use nuanced statistical methods in a large UK sample to identify and explore the factors associated with different types of frequent user of Emergency Departments (EDs) who are referred to Mental Health Liaison Services (MHLS). A retrospective 5-year longitudinal study was conducted of all attenders (n = 23,718) of four London EDs who were referred to their MHLS. Longitudinal group-based trajectory analysis of monthly MHLS referrals enabled identification of factors which may contribute to membership of the resulting groups...
December 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28954631/measurement-of-myocardial-native-t1-in-cardiovascular-diseases-and-norm-in-1291-subjects
#17
Joanna M Liu, Alexander Liu, Joana Leal, Fiona McMillan, Jane Francis, Andreas Greiser, Oliver J Rider, Saul Myerson, Stefan Neubauer, Vanessa M Ferreira, Stefan K Piechnik
BACKGROUND: Native T1-mapping provides quantitative myocardial tissue characterization for cardiovascular diseases (CVD), without the need for gadolinium. However, its translation into clinical practice is hindered by differences between techniques and the lack of established reference values. We provide typical myocardial T1-ranges for 18 commonly encountered CVDs using a single T1-mapping technique - Shortened Look-Locker Inversion Recovery (ShMOLLI), also used in the large UK Biobank and Hypertrophic Cardiomyopathy Registry study...
September 28, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28950698/enhanced-production-of-two-bioactive-isoflavone-aglycones-in-astragalus-membranaceus-hairy-root-cultures-by-combining-deglycosylation-and-elicitation-of-immobilized-edible-aspergillus-niger
#18
Jiao Jiao, Qing-Yan Gai, Li-Li Niu, Xi-Qing Wang, Na Guo, Yu-Ping Zang, Yu-Jie Fu
A cocultivation system of Astragalus membranaceus hairy root cultures (AMHRCs) and immobilized food-grade fungi was established for the enhanced production of calycosin (CA) and formononetin (FO). The highest accumulations of CA (730.88 ± 63.72 μg/g DW) and FO (1119.42 ± 95.85 μg/g DW) were achieved in 34 day-old AMHRCs cocultured with immobilized A. niger (IAN) for 54 h, which were 7.72- and 18.78-fold higher than CA and FO in nontreated control, respectively. IAN deglycosylation could promote the formation of CA and FO by conversion of their glycoside precursors...
October 5, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28948379/systemic-lupus-erythematosus-patients-with-high-disease-activity-are-associated-with-accelerated-incidence-of-osteonecrosis-a-systematic-review-and-meta-analysis
#19
Kui Zhang, Yan Zheng, Junfeng Jia, Jin Ding, Zhenbiao Wu
Osteonecrosis (ON) is one of the serious complications for systemic lupus erythematosus (SLE); we aimed to study the risk relationship between disease activity and incidence of ON in SLE patients. The PubMed, Embase, and Cochrane library databases were searched for papers published up to May 2016 with English-language restriction; studies that compared disease activity between SLE patients with and without ON would be included, and eight studies involving a total of 1119 SLE patients were included. The incidence of ON in SLE was significantly associated with high patient's disease activity, including the degree (pool odds ratio 2...
September 25, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28942508/role-of-inducible-nitric-oxide-synthase-in-myocardial-ischemia-reperfusion-injury-in-sleep-deprived-rats
#20
Sajad Jeddi, Asghar Ghasemi, Alireza Asgari, Amir Nezami-Asl
INTRODUCTION: REM sleep deprivation (SD) decreases tolerance of the rat heart to ischemia-reperfusion (IR) injury; the underlying mechanisms, however, are unknown. This study aimed at determining whether changes in iNOS, Bax, and Bcl-2 gene expression are involved in this detrimental effect. METHOD: SD was induced by flowerpot technique for a period of 4 days. This method is simple and able to induce sleep fragmentation which occurs as one of the sleep disorder symptoms in clinical conditions...
September 23, 2017: Sleep & Breathing, Schlaf & Atmung
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