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https://www.readbyqxmd.com/read/28614149/ota-classification-is-highly-predictive-of-acute-compartment-syndrome-following-tibia-fracture-a-cohort-of-2885-fractures
#1
Michael J Beebe, Darryl Auston, Jonathan Quade, Rafael Serrano-Riera, Anjan Shah, David Watson, Roy Sanders, Hassan Mir
OBJECTIVE: To determine the correlation between the OTA classification of tibia fractures and the development of acute compartment syndrome (ACS). DESIGN: Retrospective review of prospectively collected database SETTING:: Single level 1 academic trauma center PATIENTS:: All patients with a tibia fracture from 2006 to 2016. 3606 fractures were initially identified. Skeletally mature patients with plate or intramedullary fixation managed from initial injury through definitive fixation at our institution were included, leaving 2885 fractures in 2778 patients...
May 23, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28591564/effect-of-a-model-consultation-informed-by-guidelines-on-recorded-quality-of-care-of-osteoarthritis-mosaics-a-cluster-randomised-controlled-trial-in-primary-care
#2
K P Jordan, J J Edwards, M Porcheret, E L Healey, C Jinks, J Bedson, K Clarkson, E M Hay, K S Dziedzic
OBJECTIVE: To determine the effect of a model osteoarthritis (OA) consultation (MOAC) informed by National Institute for Health and Care Excellence (NICE) recommendations compared with usual care on recorded quality of care of clinical OA in general practice. DESIGN: Two-arm cluster randomised controlled trial. SETTING: Eight general practices in Cheshire, Shropshire, or Staffordshire UK. PARTICIPANTS: General practitioners and nurses with patients consulting with clinical OA...
June 4, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28587260/an-enzyme-induced-novel-biosensor-for-the-sensitive-electrochemical-determination-of-isoniazid
#3
Rajasekhar Chokkareddy, Natesh Kumar Bhajanthri, Gan G Redhi
In this present work, a glassy carbon electrode (GCE) was modified primarily with multiwalled carbon nanotubes (MWCNTs) and a composite of MWCNTs and titanium oxide nanoparticles (TiO₂NPs). The enzyme horseradish peroxidase (HRP) was immobilized to enhance the sensing ability of GCE. The proposed biosensor was used for the sensitive determination of isoniazid (INZ) in various pharmaceutical samples. The electrochemical behaviour of the developed MWCNT-TiO₂NPs-HRP-GCE biosensor was studied by using cyclic voltammetry (CV) and differential pulse voltammetric (DPV) techniques...
June 5, 2017: Biosensors
https://www.readbyqxmd.com/read/28586510/a-10-second-sprint-does-not-blunt-hormonal-counter-regulation-to-subsequent-hypoglycaemia
#4
N Paramalingam, P A Fournier, R J Davey, H C Roby, G J Smith, V B Shetty, K J Guelfi, E A Davis, T W Jones
AIM: To investigate whether a 10-second (s) sprint impairs the counter-regulatory response to subsequent hypoglycaemia. METHODS: Nine people (five male, four female) with Type 1 diabetes, aged 21.1 ± 4.5 years, performed a 10-s rest or a 10-s maximum-effort sprint in random order on different days, while subjected to an euinsulinaemic-euglycaemic clamp. This was followed by a hyperinsulinaemic-hypoglycaemic glucose clamp 2.5 h later to induce hypoglycaemia for 40 min...
June 6, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28575523/safety-and-pharmacokinetic-study-of-fidaxomicin-in-children-with-clostridium-difficile-associated-diarrhea-a-phase-2a-multicenter-clinical-trial
#5
Molly A O'Gorman, Marian G Michaels, Sheldon L Kaplan, Anthony Otley, Larry K Kociolek, Edward J Hoffenberg, Kwang Sik Kim, Sharon Nachman, Marian D Pfefferkorn, Timothy Sentongo, Janice E Sullivan, Pamela Sears
Background.: Fidaxomicin is an approved therapy for Clostridium difficile-associated diarrhea (CDAD) in adults. The safety of fidaxomicin in children has not been reported. Methods.: In this study (ClinicalTrials.gov identifier NCT01591863), pediatric patients with CDAD received twice-daily oral fidaxomicin at a dose of 16 mg/kg per day (up to 200 mg) for 10 days in an open-label study. Plasma and fecal samples were collected for pharmacokinetic assessments. The primary outcome measure was safety, which was assessed by adverse-event (AE), laboratory, and physical examination/vital-sign monitoring...
May 31, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28566080/-molecular-epidemiology-of-human-mycobacterium-bovis-infection-in-aegean-region-turkey
#6
Cengiz Çavuşoğlu, Fethiye Ferda Yılmaz
Mycobacterium bovis, which has a broader host spectrum as opposed to Mycobacterium tuberculosis that generally causes disease in humans, mainly leads to chronic progressive pulmonary disease in a large number of domestic and wild mammals, particularly cattle. The term "zoonotic tuberculosis (TB)" is used to describe M.bovis infection in humans. "Zoonotic TB" can not be differentiated clinically, radiologically or pathologically from TB caused by M.tuberculosis. The aim of this study was to evaluate the role of M...
April 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28541571/childhood-adolescent-and-young-adult-cancer-incidence-in-japan-in-2009-2011
#7
Kota Katanoda, Akiko Shibata, Tomohiro Matsuda, Megumi Hori, Kayo Nakata, Yoshitaka Narita, Chitose Ogawa, Wataru Munakata, Akira Kawai, Hiroshi Nishimoto
Little is known about cancer incidence among children and youths in Japan. We aimed to describe cancer incidence in Japan focusing on childhood, adolescence and young adulthood (AYA). Cancer incidence data were obtained from the Monitoring of Cancer Incidence in Japan project. For the 2009-2011 incidence, the data were collected from 40 prefectures, of which data from 27 prefectures meeting quality standards were analyzed (population coverage: 38.6%). Cancers diagnosed in 0-39 years of age were classified according to the International Classification of Childhood Cancer (version 3)...
May 24, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28536758/serum-levels-of-adipokines-in-patients-with-idiopathic-inflammatory-myopathies-a-pilot-study
#8
Javier Loaiza-Félix, Mariana Moreno-Ramírez, F Luis Pérez-García, Valentín Jiménez-Rojas, Fausto Sánchez-Muñoz, M Luis Amezcua-Guerra
Adipokines are cytokines not only regulating metabolic and endocrine activities, but also modulating inflammatory and immune responses in several clinical settings, including autoimmunity. This study was aimed to evaluate whether serum adipokine levels may be useful as markers of disease activity in patients with idiopathic inflammatory myopathies (IIM). Adiponectin, leptin, chemokine C-C motif ligand-2 (CCL2), interleukin (IL)-6, and tumor necrosis factor (TNF) were measured in the serum of all participants...
May 23, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28497096/patient-complaints-emphasize-non-technical-aspects-of-care-at-a-tertiary-referral-hospital
#9
John D King, Pim A D van Dijk, Celeste L Overbeek, Michiel G J S Hageman, David Ring
BACKGROUND: Patient concerns represent opportunities for improvement in orthopaedic care. This study's objective is to identify the nature and prevalence of unsolicited patient complaints regarding orthopaedic care at a tertiary referral hospital. The primary null hypothesis that there are no demographic factors associated with complaint types was tested. Secondarily we determined if the overall complaint number and types differed by year. METHODS: Complaints to the hospital ombudsperson by orthopaedic patients between January 1997 and June 2013 were reviewed...
March 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28472187/resistance-to-thrips-enneothrips-flavens-in-wild-and-amphidiploid-arachis-species
#10
Marcos Doniseti Michelotto, Ignácio José de Godoy, Melina Zacarelli Pirotta, João Francisco Dos Santos, Everton Luiz Finoto, Alessandra Pereira Fávero
Thrips (Enneothrips flavens) is a pest that causes severe damage and yield losses to peanut crop if not properly controlled. The main control method currently used by farmers is bi-weekly application of insecticides during crop development, which, in addition to its toxicity, is very costly. Thus, new sources of resistance must be identified in order to reduce the use of insecticides and effectively manage the pest. This study aimed to evaluate the occurrence and symptoms of E. flavens infestations in 12 accessions of 10 wild species of Arachis and nine amphidiploids, as well as to compare their morphoagronomic characteristics to those of commercial cultivars...
2017: PloS One
https://www.readbyqxmd.com/read/28444280/association-of-postoperative-high-sensitivity-troponin-levels-with-myocardial-injury-and-30-day-mortality-among-patients-undergoing-noncardiac-surgery
#11
P J Devereaux, Bruce M Biccard, Alben Sigamani, Denis Xavier, Matthew T V Chan, Sadeesh K Srinathan, Michael Walsh, Valsa Abraham, Rupert Pearse, C Y Wang, Daniel I Sessler, Andrea Kurz, Wojciech Szczeklik, Otavio Berwanger, Juan Carlos Villar, German Malaga, Amit X Garg, Clara K Chow, Gareth Ackland, Ameen Patel, Flavia Kessler Borges, Emilie P Belley-Cote, Emmanuelle Duceppe, Jessica Spence, Vikas Tandon, Colin Williams, Robert J Sapsford, Carisi A Polanczyk, Maria Tiboni, Pablo Alonso-Coello, Atiya Faruqui, Diane Heels-Ansdell, Andre Lamy, Richard Whitlock, Yannick LeManach, Pavel S Roshanov, Michael McGillion, Peter Kavsak, Matthew J McQueen, Lehana Thabane, Reitze N Rodseth, Giovanna A Lurati Buse, Mohit Bhandari, Ignacia Garutti, Michael J Jacka, Holger J Schünemann, Olga Lucía Cortes, Pierre Coriat, Nazari Dvirnik, Fernando Botto, Shirley Pettit, Allan S Jaffe, Gordon H Guyatt
Importance: Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac surgery (MINS). Objective: To determine the association between perioperative hsTnT measurements and 30-day mortality and potential diagnostic criteria for MINS (ie, myocardial injury due to ischemia associated with 30-day mortality). Design, Setting, and Participants: Prospective cohort study of patients aged 45 years or older who underwent inpatient noncardiac surgery and had a postoperative hsTnT measurement...
April 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28399426/hpv-related-external-genital-lesions-among-men-residing-in-brazil
#12
Roberto J C Silva, Staci L Sudenga, Laura Sichero, Maria Luiza Baggio, Lenice Galan, Ricardo Cintra, B Nelson Torres, Mark Stoler, Anna R Giuliano, Luisa L Villa
The aims of this study were to determine the incidence of external genital lesions (EGLs), specifically histologically confirmed condyloma (genital warts) and Penile Intraepithelial Neoplasia (PeIN), and genital HPV infection progression to EGLs among healthy men aged 18-73 residing in Brazil. Subjects included 1118 men enrolled in the HPV Infection in Men (HIM) study between July 2005 and June 2009. At each visit, EGLs were biopsied and subjected to pathological evaluation. HPV status in genital swabs and biopsies was determined by Linear Array and INNO-LiPA, respectively...
April 8, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28387507/subtle-structural-changes-in-cu-ii-l-2mn-ii-complexes-to-induce-heterometallic-cooperative-catalytic-oxidase-activities-on-phenolic-substrates-h2l-salen-type-unsymmetrical-schiff-base
#13
Prithwish Mahapatra, Soumavo Ghosh, Sanjib Giri, Vinayak Rane, Ramakant Kadam, Michael G B Drew, Ashutosh Ghosh
A new Cu(II) complex of an asymmetrically dicondensed Schiff base (H2L = N-(2-hydroxyacetophenylidene)-N'-salicylidene-1,3-propanediamine) derived from 1,3-propanediamine, salicylaldehyde, and o-hydroxyacetophenone has been synthesized. Using this complex, [CuL] (1), as a metalloligand, two new trinuclear Cu-Mn complexes, [(CuL)2Mn(N3)(H2O)](ClO4)·H2O (2) and [(CuL)2Mn(NCS)2] (3), have been prepared. Single-crystal structural analyses reveal that complexes 2 and 3 both have the same bent trinuclear {(CuL)2Mn}(2+) structural unit in which two terminal bidentate square-planar (CuL) units are chelated to the central octahedral Mn(II) ion...
April 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28355982/low-copy-numbers-of-fcgr3a-and-fcgr3b-associated-with-chinese-patients-with-sle-and-aasv
#14
Y Qi, X Zhou, D Bu, P Hou, J Lv, H Zhang
Low-affinity Fcγ receptors (FcγR) act as key mediators of the pathogenic effects of autoantibodies. In this study, we aimed to determine whether copy number variations (CNVs) in FCGR3A and FCGR3B were associated with systemic lupus nephritis (SLE) and ANCA-associated systemic vasculitis (AASV) in Chinese individuals. A total of 1118 individuals were enrolled, including 415 SLE patients, 139 AASV patients, and 564 healthy controls. FCGR3A and FCGR3B copy numbers (CNs) were determined by both a paralogue ratio test and TaqMan quantitative PCR assay...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28342776/effect-of-needle-size-in-ultrasound-guided-core-needle-breast-biopsy-comparison-of-14-16-and-18-gauge-needles
#15
Michela Giuliani, Pierluigi Rinaldi, Rossella Rella, Gina Fabrizi, Federica Petta, Giorgio Carlino, Alba Di Leone, Antonino Mulè, Enida Bufi, Maurizio Romani, Paolo Belli, Lorenzo Bonomo
INTRODUCTION: The aim of the present study was to assess the diagnostic accuracy of ultrasound-guided core needle biopsy (US-CNB) of breast lesions, comparing smaller needles (16- and 18-gauge) with the 14-gauge needle, and to analyze the lesion characteristics influencing US-CNB diagnostic performance. PATIENTS AND METHODS: All the patients provided informed consent before the biopsy procedure. The data from breast lesions that had undergone US-CNB in our institution from January 2011 to January 2015 were retrospectively reviewed...
March 6, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28334427/capnography-versus-standard-monitoring-for-emergency-department-procedural-sedation-and-analgesia
#16
REVIEW
Brian F Wall, Kirk Magee, Samuel G Campbell, Peter J Zed
BACKGROUND: Procedural sedation and analgesia (PSA) is used frequently in the emergency department (ED) to facilitate painful procedures and interventions. Capnography, a monitoring modality widely used in operating room and endoscopy suite settings, is being used more frequently in the ED setting with the goal of reducing cardiopulmonary adverse events. As opposed to settings outside the ED, there is currently no consensus on whether the addition of capnography to standard monitoring modalities reduces adverse events in the ED setting...
March 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28333569/are-preferences-for-aggressive-medical-treatment-associated-with-healthcare-utilization-in-the-very-old
#17
Steven M Albert, June R Lunney, Lei Ye, Robert Boudreau, Diane Ives, Suzanne Satterfield, Cameron M Kaplan, Teresa Waters, Hilsa N Ayonayon, Susan M Rubin, Anne B Newman, Tamara Harris
OBJECTIVES: To examine the relationship between end-of-life (EOL) treatment preferences and recent hospitalization or emergency department (ED) care in the very old. DESIGN: Quarterly telephone follow-up of participants in the EOL in the Very Old cohort. SETTING: The EOL in the Very Old Age cohort drew from 1403 participants in the Health, Aging, and Body Composition (Health ABC) study who were alive in year 15 of follow-up. 87.5% (n = 1227) were successfully recontacted and enrolled...
March 23, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28323479/evaluation-of-measles-mumps-rubella-vaccination-among-newly-arrived-refugees
#18
Deborah Lee, Michelle Weinberg, Stephen Benoit
OBJECTIVES: To assess US availability and use of measles-mumps-rubella (MMR) vaccination documentation for refugees vaccinated overseas. METHODS: We selected 1500 refugee records from 14 states from March 2013 through July 2015 to determine whether overseas vaccination records were available at the US postarrival health assessment and integrated into the Advisory Committee on Immunization Practices schedule. We assessed number of doses, dosing interval, and contraindications...
May 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28292963/electrical-activity-of-the-diaphragm-during-ncpap-and-high-flow-nasal-cannula
#19
C G de Waal, G J Hutten, J V Kraaijenga, F H de Jongh, A H van Kaam
OBJECTIVE: To determine if the electrical activity of the diaphragm, as measure of neural respiratory drive and breathing effort, changes over time in preterm infants transitioned from nasal continuous positive airway pressure (nCPAP) to high flow nasal cannula (HFNC). DESIGN: Prospective observational study. SETTING: Neonatal intensive care unit. PATIENTS: Stable preterm infants transitioned from nCPAP to HFNC using a 1:1 pressure to flow ratio...
March 14, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28282654/approach-to-human-immunodeficiency-virus-sexually-transmitted-infection-testing-for-men-at-an-urban-urgent-care-center
#20
Sarah B Schechter, Dina L Romo, Alwyn T Cohall, Natalie M Neu
BACKGROUND AND OBJECTIVES: Sexually transmitted infection (STI) rates have increased among men. Urgent care centers are increasingly common sites for medical care. The objectives of this study are to describe practices surrounding STI testing at an urban urgent care center. METHODS: Electronic medical record data were analyzed for men ages 20 to 55 years seen at the urgent care center of a large urban hospital from June 7, 2011, to April 30, 2015 (n = 10,983). A subset of charts was reviewed to assess sexual history documentation (n = 906)...
April 2017: Sexually Transmitted Diseases
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