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https://www.readbyqxmd.com/read/29045932/modulation-of-sestrin-confers-protection-to-cr-vi-induced-neuronal-cell-death-in-drosophila-melanogaster
#1
Pallavi Singh, D Kar Chowdhuri
Increased oxidative stress is one of the major causes of hexavalent chromium [Cr(VI)], a heavy metal with diverse applications and environmental presence, induced neuronal adversities in exposed organism including Drosophila. Sestrin (sesn), an oxidative stress responsive gene, emerges as a novel player in the management of oxidative stress response. It is reported to be regulated by Target of rapamycin (TOR) and the former regulates autophagy and plays an important role in the prevention of neurodegeneration...
October 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29038278/fidaxomicin-and-op-1118-inhibit-c-difficile-toxin-a-and-b-mediated-inflammatory-responses-via-inhibition-of-nf-%C3%AE%C2%BAb-activity
#2
Hon Wai Koon, Jiani Wang, Caroline C Mussatto, Christina Ortiz, Elaine C Lee, Diana Hoang-Ngoc Tran, Xinhua Chen, Ciaran P Kelly, Charalabos Pothoulakis
Objective:Clostridium difficile causes diarrhea and colitis by releasing toxin A and toxin B. In the human colon, both toxins cause intestinal inflammation and stimulate TNFα expression via activation of NF-κB. It is well established that the macrolide antibiotic fidaxomicin is associated with reduced relapses of C. difficile infection. We showed that fidaxomicin and its primary metabolite, OP-1118, significantly inhibited toxin A-mediated intestinal inflammation in mice in vivo and toxin A-induced cell rounding in vitro We aim to determine whether fidaxomicin and OP-1118 possess anti-inflammatory effects against toxin A and toxin B in the human colon and examine the mechanism of this response...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29032401/fine-mapping-of-the-genic-male-sterile-ms-1-gene-in-capsicum-annuum-l
#3
Kyumi Jeong, Doil Choi, Jundae Lee
The genomic region cosegregating with the genic male-sterile ms 1 gene of Capsicum annuum L. was delimited to a region of 869.9 kb on chromosome 5 through fine mapping analysis. A strong candidate gene, CA05g06780, a homolog of the Arabidopsis MALE STERILITY 1 gene that controls pollen development, was identified in this region. Genic male sterility caused by the ms 1 gene has been used for the economically efficient production of massive hybrid seeds in paprika (Capsicum annuum L.), a colored bell-type sweet pepper...
October 14, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29030095/postoperative-rehabilitation-following-thumb-base-surgery-a-systematic-review-of-the-literature
#4
REVIEW
Robbert M Wouters, Jonathan Tsehaie, Steven E R Hovius, Burcu Dilek, Ruud W Selles
OBJECTIVE: To provide an overview of rehabilitation for patients who underwent CMC-1 arthroplasty, with emphasis on early active mobilization. DATA SOURCES/STUDY SELECTION: PubMed/MEDLINE, Embase, CINAHL and Cochrane were searched for articles written in English that described postoperative regime (including immobilization period/method and/or description of exercises/physical therapy, follow-up ≥six weeks) on CMC-1 arthroplasty. DATA EXTRACTION: The PRISMA statement was used as guidance in this review and methodological quality was assessed using the Effective Public Health Practice Project quality assessment tool...
October 10, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29027301/challenges-of-post-authorization-safety-studies-lessons-learned-and-results-of-a-french-study-of-fentanyl-buccal-tablet
#5
REVIEW
Natalie Gavrielov-Yusim, Ilda Bidollari, Sigal Kaplan, Netta Bartov
PURPOSE: Recruiting and retaining participants in real-world studies that collect primary data are challenging. This article illustrates these challenges using a post-authorization safety study (PASS) to assess adverse events (AEs) experienced with fentanyl buccal tablet (FBT) over 3 months of treatment. METHODS: This was an observational, prospective, multicenter study in France conducted over 1 year. The study employed primary data collection in FBT-treated patients and their treating physicians via a site qualification questionnaire and patient log completed by physicians and a questionnaire and pain diary completed by patients...
October 13, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28984188/scapd-a-database-for-human-scaffold-proteins
#6
Xiaomei Han, Jenny Wang, Jie Wang, Sheng Liu, Jianfei Hu, Heng Zhu, Jiang Qian
BACKGROUND: Scaffold proteins play a critical role in an increasing number of biological signaling processes, including simple tethering mechanism, regulating selectivity in pathways, shaping cellular behaviors. While many databases document the signaling pathways, few databases are devoted to the scaffold proteins that medicate signal transduction. RESULTS: Here, we have developed a user-friendly database, ScaPD, to describe computationally predicted, experimentally validated scaffold proteins and associated signaling pathways...
October 3, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28946871/ntprobnp-in-insulin-resistance-mediated-conditions-overweight-obesity-metabolic-syndrome-and-diabetes-the-population-based-casale-monferrato-study
#7
Stefano Baldassarre, Salvatore Fragapani, Antonio Panero, Debora Fedele, Silvia Pinach, Manuela Lucchiari, Anna Rita Vitale, Giulio Mengozzi, Gabriella Gruden, Graziella Bruno
BACKGROUND AND AIMS: NTproBNP and BNP levels are reduced in obese subjects, but population-based data comparing the pattern of this relationship in the full spectrum of insulin-resistance mediated conditions, overweight/obesity, metabolic syndrome and diabetes, are limited. METHODS: The study-base were 3244 individuals aged 45-74 years, none of whom had heart failure, 1880 without diabetes and 1364 with diabetes, identified as part of two surveys of the population-based Casale Monferrato Study...
September 25, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28938337/pulse-pressure-is-associated-with-plasma-amyloid-%C3%AE-transport-dysfunction
#8
Yu Jiang, Suhang Shang, Pei Li, Chen Chen, Liangjun Dang, Jin Wang, Kang Huo, Meiying Deng, Jingyi Wang, Qiumin Qu
OBJECTIVE: Increased pulse pressure (PP) has been implicated in the development and progression of Alzheimer's disease in middle-aged and elderly adults. Considering the close relationship between peripheral amyloid-β clearance and brain amyloid-β deposition, we investigated the potential association between PP and plasma amyloid-β transport function. METHODS: In this cross-sectional study, a total of 1118 participants underwent a health assessment and quantification of plasma amyloid-β and amyloid-β transporter expression...
September 21, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28931037/assessment-of-renal-function-in-routine-care-of-people-living-with-hiv-on-art-in-a-resource-limited-setting-in-urban-zambia
#9
Andreas Deckert, Florian Neuhann, Christina Klose, Thomas Bruckner, Claudia Beiersmann, John Haloka, Mannie Nsofwa, Greg Banda, Maik Brune, Helmut Reutter, Dietrich Rothenbacher, Martin Zeier
INTRODUCTION: Data on renal impairment in sub-Saharan Africa (SSA) remains scarce, determination of renal function is not part of routine assessments. We evaluated renal function and blood pressure in a cohort of people living with HIV (PLWH) on antiretroviral treatment (ART) in the Renal Care Zambia project (ReCaZa). METHODS: Using routine data from an HIV outpatient clinic from 2011-2013, we retrospectively estimated the glomerular filtration rate (eGFR, CKD-Epi formula) of PLWH on ART in Lusaka, Zambia...
2017: PloS One
https://www.readbyqxmd.com/read/28926867/diabetes-associated-biobanking-more-topical-than-ever
#10
Katharina Lydia Kynast, Nadine Volk, Thomas Fleming, Esther Herpel
The increasing prevalence of diabetes and its accompanying long-term complications, as well as the associated economic burden, calls for a rapid clinical translation of biomedical research to better valid the physiological relevance of the findings from basic research. To meet this condition, the Collaborative Research Center (CRC) 1118 has established the first nationwide diabetes-specific Biomaterialbank (BMB) that permanently preserves solid and liquid specimen retro- and prospectively at the Institute of Pathology and Department of Endocrinology of the University Hospital Heidelberg...
September 19, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28915852/a-novel-frameshift-grn-mutation-results-in-frontotemporal-lobar-degeneration-with-a-distinct-clinical-phenotype-in-two-siblings-case-report-and-literature-review
#11
Takashi Hosaka, Kazuhiro Ishii, Takeshi Miura, Naomi Mezaki, Kensaku Kasuga, Takeshi Ikeuchi, Akira Tamaoka
BACKGROUND: Progranulin gene (GRN) mutations are major causes of frontotemporal lobar degeneration. To date, 68 pathogenic GRN mutations have been identified. However, very few of these mutations have been reported in Asians. Moreover, some GRN mutations manifest with familial phenotypic heterogeneity. Here, we present a novel GRN mutation resulting in frontotemporal lobar degeneration with a distinct clinical phenotype, and we review reports of GRN mutations associated with familial phenotypic heterogeneity...
September 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28914955/alcohol-related-mortality-in-patients-with-psoriasis-a-population-based-cohort-study
#12
Rosa Parisi, Roger T Webb, Matthew J Carr, Kieran J Moriarty, C Elise Kleyn, Christopher E M Griffiths, Darren M Ashcroft
Importance: People diagnosed with psoriasis have an increased risk of premature mortality, but the underlying reasons for this mortality gap are unclear. Objective: To investigate whether patients with psoriasis have an elevated risk of alcohol-related mortality. Design, Setting, and Participants: An incident cohort of patients with psoriasis aged 18 years and older was delineated for 1998 through 2014 using the Clinical Practice Research Datalink (CPRD) and linked to Hospital Episode Statistics (HES) and Office for National Statistics (ONS) mortality records...
September 15, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28833937/impact-of-coculturing-bifidobacterium-animalis-subsp-lactis-hn019-with-yeasts-on-microbial-viability-and-metabolite-formation
#13
M Toh, S-Q Liu
AIMS: To evaluate the impact of coculturing Bifidobacterium animalis subsp. lactis HN019 with yeasts on microbial viability and metabolite production. METHODS AND RESULTS: Monocultures and bacteria-yeast cocultures of B. lactis HN019 and 10 different yeast strains belonging to different species in skim milk media were fermented at 37°C. The presence of yeasts enhanced the growth rate and metabolic activities of B. lactis HN019, which might be attributed to their antioxidative properties...
August 18, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28804399/care-service-use-in-2-years-preceding-suicide-among-older-adults-comparison-with-those-who-died-a-natural-death-and-those-who-lived-longer
#14
Leena Forma, Mari Aaltonen, Jutta Pulkki, Jani Raitanen, Pekka Rissanen, Marja Jylhä
The aim of the study is (1) to describe and analyse health and social service use and medicine purchases in the last 2 years of life among older adults who died by suicide and (2) to compare use and purchases between three groups: those who died by suicide, died a natural death or who lived longer. Nation-wide Finnish register data were used. The data consist of 316,639 decedents who died at the age of 70 years or older in 1998-2008 and 222,967 people who lived longer. Use of hospital, long-term care and home care, and the purchase of prescribed psychotropic medications were studied for the 2-year period...
June 2017: European Journal of Ageing
https://www.readbyqxmd.com/read/28756883/caspofungin-treatment-for-pulmonary-invasive-fungal-disease-in-hematology-patients-a-retrospective-study-in-a-clinical-practice-setting-in-china
#15
Xiaohui Zhang, Jiong Hu, Yu Hu, He Huang, Jie Jin, Juan Li, Qifa Liu, Zonghong Shao, Jianxiang Wang, Quanshun Wang, Depei Wu, Xiaojun Huang
PURPOSE: Invasive fungal disease (IFD) is a serious complication in patients with hematologic malignancies. Caspofungin is the first approved inhibitor of fungal β-1,3-glucan synthesis. The aim of the present study was to evaluate the effectiveness of caspofungin in the treatment of IFD in patients with hematologic malignancies. METHODS: In this retrospective study, data from the electronic medical records of 1118 inpatients who were admitted to 10 hospitals in China between 2013 and 2014 were analyzed...
September 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28750010/intensive-care-discharge-delay-is-associated-with-increased-hospital-length-of-stay-a-multicentre-prospective-observational-study
#16
MULTICENTER STUDY
Ravindranath Tiruvoipati, John Botha, Jason Fletcher, Himangsu Gangopadhyay, Mainak Majumdar, Sanjiv Vij, Eldho Paul, David Pilcher
BACKGROUND: Some patients experience a delayed discharge from the intensive care unit (ICU) where the intended and actual discharge times do not coincide. The clinical implications of this remain unclear. OBJECTIVE: To determine the incidence and duration of delayed ICU discharge, identify the reasons for delay and evaluate the clinical consequences. METHODS: Prospective multi-centre observational study involving five ICUs over a 3-month period...
2017: PloS One
https://www.readbyqxmd.com/read/28718391/corrigendum
#17
(no author information available yet)
Operating and environmental performances of commercial-scale waste gasification and melting technology by Nobuhiro Tanigaki, Yasuka Fujinaga, Hirohisa Kajiyama, and Yoshihiro Ishida. Waste Management & Research 2013; 31: 1118-1124, DOI: 10.1177/0734242X13502386. The authors regret that they omitted the following declaration of conflicting interest in the article: Declaration of Conflicting Interest At the time of publication, all authors were employed by Nippon Steel & Sumikin Engineering Co., Ltd. Technology developed by Nippon Steel & Sumikin Engineering Co...
July 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28697592/out-of-pocket-expenditure-in-accessing-healthcare-services-among-chronic-kidney-disease-patients-in-anuradhapura-district
#18
S J Senanayake, N S Gunawardena, P Palihawadana, S Bandara, P Bandara, A U Ranasinghe, R H Karunarathna, G P Kumara
Introduction: Chronic Kidney Disease (CKD) has significant economic impact on both patients’ households and the country. Objectives: To assess the out-of-pocket (OOP) expenditure of accessing health services among CKD patients in Anuradhapura District Methods: This community based cross-sectional study included a representative sample of 1174 registered CKD patients from all 19 Medical Officer of Health areas in the District of Anuradhapura...
June 30, 2017: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28693434/symptom-burden-in-chronic-kidney-disease-a-population-based-cross-sectional-study
#19
Sameera Senanayake, Nalika Gunawardena, Paba Palihawadana, Palitha Bandara, Rashan Haniffa, R Karunarathna, Priyantha Kumara
BACKGROUND: Physical and psychological symptoms are among main manifestations of Chronic Kidney Disease (CKD). This study aimed to assess the symptom burden and self-perceived severity of symptoms among CKD patients living in a district in Sri Lanka. METHOD: A community based cross-sectional study included a sample of randomly selected 1174 CKD patients from all 19 Medical Officer of Health areas in the district of Anuradhapura. Trained para-medical staff visited the households and administered the locally validated questionnaire to assess the presence and severity of symptoms...
July 10, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28614149/ota-ao-classification-is-highly-predictive-of-acute-compartment-syndrome-after-tibia-fracture-a-cohort-of-2885-fractures
#20
Michael J Beebe, Darryl A Auston, Jonathan H Quade, Rafael Serrano-Riera, Anjan R Shah, David T Watson, Roy W Sanders, Hassan R Mir
OBJECTIVE: To determine the correlation between the OTA/AO classification of tibia fractures and the development of acute compartment syndrome (ACS). DESIGN: Retrospective review of prospectively collected database. SETTING: Single Level 1 academic trauma center. PATIENTS: All patients with a tibia fracture from 2006 to 2016 were reviewed for this study. Three thousand six hundred six fractures were initially identified...
November 2017: Journal of Orthopaedic Trauma
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