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https://www.readbyqxmd.com/read/29454066/walking-behavior-in-a-circular-arena-modified-by-pulsed-light-stimulation-in-drosophila-melanogaster-w-1118-line
#1
Shuang Qiu, Chengfeng Xiao
The Drosophila melanogaster white-eyed w 1118 line serves as a parental stock, allowing genetic recombination of any gene of interest along with a readily recognizable marker. w 1118 flies display behavioral susceptibility to environmental stimulation such as light. It is of great importance to characterize the behavioral performance of w 1118 flies because this would provide a baseline from which the effect of the gene of interest could be differentiated. Little work has been performed to characterize the walking behavior in adult w 1118 flies...
February 14, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29402974/genetic-variability-affects-absolute-and-relative-potencies-and-kinetics-of-the-anesthetics-isoflurane-and-sevoflurane-in-drosophila-melanogaster
#2
Zachariah P G Olufs, Carin A Loewen, Barry Ganetzky, David A Wassarman, Misha Perouansky
Genetic variability affects the response to numerous xenobiotics but its role in the clinically-observed irregular responses to general anesthetics remains uncertain. To investigate the pharmacogenetics of volatile general anesthetics (VGAs), we developed a Serial Anesthesia Array apparatus to expose multiple Drosophila melanogaster samples to VGAs and behavioral assays to determine pharmacokinetic and pharmacodynamic properties of VGAs. We studied the VGAs isoflurane and sevoflurane in four wild type strains from the Drosophila Genetic Reference Panel, two commonly used laboratory strains (Canton S and w 1118 ), and a mutant in Complex I of the mitochondrial electron transport chain (ND23 60114 )...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29401091/pathoanatomy-of-the-tongue-type-calcaneus-fracture-assessment-using-2-and-3-dimensional-computed-tomography
#3
Phillip M Mitchell, David E O'Neill, Bethany Gallagher, Cory A Collinge
OBJECTIVE: To define the pathoanatomy of the tongue type calcaneus fracture and assess the appropriateness of percutaneous techniques in addressing all planes of deformity in this injury. DESIGN: Retrospective cohort. SETTING: ACS Level I trauma center. PATIENTS/PARTICIPANTS: Fifty-six displaced Sanders 2B and 2C tongue type calcaneus fractures identified from an initial cohort of 1118 calcaneus fractures treated over a 16-year period...
January 26, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29373265/susceptibility-of-clostridium-species-isolated-in-japan-to-fidaxomicin-and-its-major-metabolite-op-1118
#4
Katsunori Yanagihara, Norihiko Akamatsu, Junichi Matsuda, Norihito Kaku, Kiyomitsu Katsumata, Kosuke Kosai
The narrow-spectrum macrocyclic antibiotic fidaxomicin is approved for treatment of Clostridium difficile infection in many countries and is currently under evaluation in Japan for this indication. This study was conducted to evaluate the effects of fidaxomicin and its major metabolite, OP-1118, on Clostridium spp. isolated in Nagasaki University Hospital, Japan. Isolates were cultured and antimicrobial susceptibility analyses performed according to the Clinical Laboratory Standards Institute methods. Ninety-eight isolates were obtained between 2012 and 2015, 50 of C...
January 17, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29362959/single-item-measures-for-detecting-sleep-problems-in-united-states-military-veterans
#5
Jaime M Hughes, Christi S Ulmer, Jennifer M Gierisch, Matthew O Howard
BACKGROUND: As many as two-thirds of post-9/11 military veterans complain of sleep problems, including insomnia-like symptoms. Left untreated, chronic sleep problems increase the risk for a range of negative outcomes, including incident mental health disorders. However, sleep problems remain overlooked in primary care settings. To date, no brief sleep screeners have been developed or validated. Items assessing insomnia and poor sleep are often embedded into commonly used psychological assessments, and may serve as a viable first step in screening...
January 23, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29358412/pillars-article-efficient-presentation-of-soluble-antigen-by-cultured-human-dendritic-cells-is-maintained-by-granulocyte-macrophage-colony-stimulating-factor-plus-interleukin-4-and-downregulated-by-tumor-necrosis-factor-%C3%AE-j-exp-med-1994-179-1109-1118
#6
Federica Sallusto, Antonio Lanzavecchia
No abstract text is available yet for this article.
February 1, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29322858/epidemiology-of-mental-health-conditions-in-incoming-division-i-collegiate-athletes
#7
Nikolas Sarac, Benjamin Sarac, Angela Pedroza, James Borchers
OBJECTIVES: The purpose of this study is to examine the epidemiology of mental health conditions in incoming American Division I collegiate athletes. METHODS: Pre-participation physical questionnaires from 1118 incoming student athletes at a Division I Institution were collected retrospectively from 2011-2017. Data collected included lifetime history of any mental health condition, musculoskeletal injuries, concussions, and post-concussion depression. History of any mental health condition was evaluated by gender and sport played...
January 20, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29304943/using-a-discrete-choice-experiment-involving-cost-to-value-a-classification-system-measuring-the-quality-of-life-impact-of-self-management-for-diabetes
#8
Donna Rowen, Katherine Stevens, Alexander Labeit, Jackie Elliott, Brendan Mulhern, Jill Carlton, Hasan Basarir, Julie Ratcliffe, John Brazier
OBJECTIVES: To describe the use of a novel approach in health valuation of a discrete-choice experiment (DCE) including a cost attribute to value a recently developed classification system for measuring the quality-of-life impact (both health and treatment experience) of self-management for diabetes. METHODS: A large online survey was conducted using DCE with cost on UK respondents from the general population (n = 1497) and individuals with diabetes (n = 405). The data were modeled using a conditional logit model with robust standard errors...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29238243/analysis-of-time-motion-and-heart-rate-in-elite-male-and-female-beach-handball
#9
Basilio Pueo, Jose M Jimenez-Olmedo, Alfonso Penichet-Tomas, Manuel Ortega Becerra, Jose J Espina Agullo
Beach handball is a spectacular new team sport; however, scientific knowledge about the demands in beach handball is very low. Consequently, the aim of this study was to analyze the physical demands of elite beach handball players by means of time-motion analysis with GPS technology and physiological response with Heart Rate (HR). Both male (n = 12) and female (n = 12) players from the Spanish Beach Handball National Team were recruited for this study. The sample consisted in four matches of two 10-min periods each...
December 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29218255/oncology-section-edge-task-force-on-urogenital-cancer-a-systematic-review-of-clinical-measures-for-incontinence
#10
Alicia Jeffrey, Shana E Harrington, Alexandra Hill, Amanda Roscow, Meryl Alappattu
Background: Compared to the general population, women and men with urogenital and colorectal cancer experience higher rates of urinary and fecal incontinence. Although a variety of measures exist to assess these areas, currently, there are no guidelines recommending which outcomes rehabilitation professionals should administer to examine these impairments in those with cancer. Purpose: To identify outcome measures for assessing urinary and fecal incontinence and evaluate their psychometric data and applicability to the cancer population...
July 2017: Rehabilitation Oncology
https://www.readbyqxmd.com/read/29167926/angiopoietin-like-protein-8-in-early-pregnancy-improves-the-prediction-of-gestational-diabetes
#11
Yun Huang, Xin Chen, Xiaohong Chen, Yu Feng, Heming Guo, Sicheng Li, Ting Dai, Rong Jiang, Xiaoyan Zhang, Chen Fang, Ji Hu
AIMS/HYPOTHESIS: Screening high-risk individuals for gestational diabetes mellitus (GDM) in early pregnancy conventionally relies on established maternal risk factors; however, the sensitivity and specificity of these factors are not satisfactory. The present study aimed to determine whether the concentration of angiopoietin-like protein 8 (ANGPTL8), either alone or combined with other risk factors in early pregnancy, could be used to predict subsequent GDM. METHODS: From August 2015 to January 2016, 474 women receiving prenatal care at around 12-16 weeks of gestation were recruited into the study...
November 22, 2017: Diabetologia
https://www.readbyqxmd.com/read/29152127/minocycline-treatment-increases-resistance-to-oxidative-stress-and-extends-lifespan-in-drosophila-via-foxo
#12
Gang Jun Lee, Jin Ju Lim, Seogang Hyun
Minocycline is a semi-synthetic tetracycline derivative antibiotic that has received increasing attention for its non-antibiotic properties, mainly anti-inflammatory, tumor-suppressive, and neuroprotective effects. Drosophila is a widely used genetically tractable model organism for studying organismal aging by virtue of its short lifespan and ease of cultivation. In this study, we examined the effects of minocycline on Drosophila lifespan and its associated traits. Minocycline-supplemented food significantly extended lifespan in both Canton S and w(1118) Drosophila strains...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29141060/efficacy-of-low-fluence-nd-yag-1064-nm-laser-for-the-treatment-of-post-inflammatory-hyperpigmentation-in-the-axillary-area
#13
Sahar Ghannam, Fatemah K Al Otabi, Konstantin Frank, Sebastian Cotofana
<p>OBJECTIVE: Post-inflammatory hyperpigmentation results in aesthetically unpleasant discoloration of the skin in the affected area. The efficacy of low-fluence Q-switched 1064-nm Nd:YAG laser has so far not been evaluated for the treatment of the axilla. This observational study was designed to evaluate whether the application of the laser treatment can satisfactorily reduce axillary hyperpigmentation. MATERIAL AND METHODS: 17 females (mean age, 34.27 ± 9.24; range, 19-48) were treated in a single center between 2014 and 2016 for post-inflammatory hyperpigmentation of the axillary area...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29119571/targeted-exome-sequencing-defines-novel-and-rare-variants-in-complex-blood-group-serology-cases-for-a-red-blood-cell-reference-laboratory-setting
#14
Elizna M Schoeman, Eileen V Roulis, Yew-Wah Liew, Jacqueline R Martin, Tanya Powley, Brett Wilson, Glenda M Millard, Eunike C McGowan, Genghis H Lopez, Helen O'Brien, Jennifer A Condon, Robert L Flower, Catherine A Hyland
BACKGROUND: We previously demonstrated that targeted exome sequencing accurately defined blood group genotypes for reference panel samples characterized by serology and single-nucleotide polymorphism (SNP) genotyping. Here we investigate the application of this approach to resolve problematic serology and SNP-typing cases. STUDY DESIGN AND METHODS: The TruSight One sequencing panel and MiSeq platform was used for sequencing. CLC Genomics Workbench software was used for data analysis of the blood group genes implicated in the serology and SNP-typing problem...
November 8, 2017: Transfusion
https://www.readbyqxmd.com/read/29114259/identification-of-splicing-quantitative-trait-loci-sqtl-in-drosophila-melanogaster-with-developmental-lead-pb-2-exposure
#15
Wen Qu, Katherine Gurdziel, Roger Pique-Regi, Douglas M Ruden
Lead (Pb) poisoning has been a major public health issue globally and the recent Flint water crisis has drawn nation-wide attention to its effects. To better understand how lead plays a role as a neurotoxin, we utilized the Drosophila melanogaster model to study the genetic effects of lead exposure during development and identified lead-responsive genes. In our previous studies, we have successfully identified hundreds of lead-responsive expression QTLs (eQTLs) by using RNA-seq analysis on heads collected from the Drosophila Synthetic Population Resource...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29100984/sexual-dimorphism-in-oxidant-induced-adaptive-homeostasis-in-multiple-wild-type-d-melanogaster-strains
#16
Laura C D Pomatto, Sarah Wong, John Tower, Kelvin J A Davies
Sexual dimorphism includes the physical and reproductive differences between the sexes, including differences that are conserved across species, ranging from the common fruit fly, Drosophila melanogaster, to humans. Sex-dependent variations in adaptive homeostasis, and adaptive stress responses may offer insight into the underlying mechanisms for male and female survival differences and into differences in chronic disease incidence and severity in humans. Earlier work showed sex-specific differences in adaptive responses to oxidative stressors in hybrid laboratory strains of D...
October 31, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29082117/oncology-section-edge-task-force-on-cancer-a-systematic-review-of-patient-reported-measures-for-sexual-dysfunction
#17
Meryl Alappattu, Shana E Harrington, Alexandra Hill, Amanda Roscow, Alicia Jeffrey
BACKGROUND: Sexual dysfunction is an important and infrequently addressed issue in patients with cancer. PURPOSE: To identify self-report measures for assessing sexual dysfunction and to evaluate their psychometric properties and relevance to patients with cancer. METHODS: Multiple electronic databases (CINAHL, Medline, PsycInfo) were reviewed using specific search terms to locate articles that identify self-report measures assessing sexual dysfunction...
July 2017: Rehabilitation Oncology
https://www.readbyqxmd.com/read/29076439/influence-of-shift-work-on-manual-dexterity-and-reaction-time-in-tunisian-nurses
#18
Irtyah Merchaoui, N Chaari, Mohamed Bouhlel, Lamia Bouzgarrou, Jacques Malchaire, Mohamed Akrout
BACKGROUND: Major effects of shift schedule are related to sleep alertness and performance , but also to long term health outcomes. For nurses, these negative effects have consequences not only on the individual, but also on the workplace, as decreased alertness and reduced job performance could endanger human lives. OBJECTIVE: The specific aim of our study is to assess the influence of shift schedule on nurses´ cognitive ability and rapidity of execution. METHOD: Our survey is a cross sectional study which had been conducted for 15 months; it involved a sample of 293 participants representative of 1118 nurses working in two Tunisian university hospitals...
October 26, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29064659/cobalt-ii-magnetic-metal-organic-framework-with-an-effective-kagom%C3%A3-lattice-large-surface-area-and-high-spin-canted-ordering-temperature
#19
Tao Zhang, Yue-Qiao Hu, Zong-Wen Mo, Pei-Qin Liao, Hiroshi Sakiyama, Tian Han, Xiao-Ming Chen, Yan-Zhen Zheng
To make a porous material with high magnetic ordering temperature is challenging because the low density of the material is adverse to the dense magnetic moment, a prerequisite to high-performance magnets. Herein, we report a hollow magnetic metal-organic framework (MMOF) [Co3(bpdc)3(tpt)0.66] 1 (H2bpdc = 4,4'-biphenyldicarboxylic acid) with a Langmuir surface area of 1118 m(2)/g and spin-canted long-range magnetic ordering up to 22 K. Such a high performance is owing to the unique antiferromagnetic Kagomé lattice made of ferromagnetic Co3 clusters and conjugated 2,4,6-tri(4-pyridinyl)-1,3,5-triazine (tpt) ligands, which is closely coupled with each other via double-interpenetration of the porous networks...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29045932/modulation-of-sestrin-confers-protection-to-cr-vi-induced-neuronal-cell-death-in-drosophila-melanogaster
#20
Pallavi Singh, D Kar Chowdhuri
Increased oxidative stress is one of the major causes of hexavalent chromium [Cr(VI)], a heavy metal with diverse applications and environmental presence, induced neuronal adversities in exposed organism including Drosophila. Sestrin (sesn), an oxidative stress responsive gene, emerges as a novel player in the management of oxidative stress response. It is reported to be regulated by Target of rapamycin (TOR) and the former regulates autophagy and plays an important role in the prevention of neurodegeneration...
October 7, 2017: Chemosphere
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