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https://www.readbyqxmd.com/read/29763655/no-evidence-of-adverse-pregnancy-outcome-after-exposure-to-ibuprofen-in-the-1st-trimester-evaluation-of-the-national-embryotox-cohort
#1
Katarina Dathe, Anne-Katrin Fietz, Lucas William Pritchard, Stephanie Padberg, Stefanie Hultzsch, Katja Meixner, Reinhard Meister, Christof Schaefer
Ibuprofen is an analgesic frequently used in the 1st and 2nd trimester of pregnancy. Most relevant studies deal with NSAID as a group and do not specifically focus on ibuprofen. In this study, 1117 women exposed to ibuprofen in the 1st trimester were compared to 2229 non-exposed women. Data were retrieved from the German Embryotox database. No significantly increased risk of major birth defects (4.8% vs. 4.1%; OR adjusted 1.11, 95% CI 0.75-1.64) or a distinct pattern of birth defects were found. The cumulative incidences of spontaneous abortions were similar across cohorts (15...
May 12, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29748913/efficacy-and-tolerability-of-fixed-dose-combination-perindopril-indapamide-in-hypertensive-patients-with-a-history-of-stroke-or-transient-ischemic-attack-picasso-trial
#2
Csaba András Dézsi, Csaba Farsang
INTRODUCTION: In everyday medical practice, physicians often need to manage patients whose blood pressure is not well controlled. Those with a history of cerebrovascular disease are a high-risk group in need of rapid blood pressure control. METHODS: The PICASSO study was a real-life, observational trial involving 9257 inadequately treated hypertensive patients who were switched from previous therapy to the fixed-dose combination of perindopril 10 mg/indapamide 2...
May 10, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29714335/hybrid-method-to-estimate-two-layered-superficial-tissue-optical-properties-from-simulated-data-of-diffuse-reflectance-spectroscopy
#3
Hong-Po Hsieh, Fan-Hua Ko, Kung-Bin Sung
An iterative curve fitting method has been applied in both simulation [J. Biomed. Opt.17, 107003 (2012)JBOPFO1083-366810.1117/1.JBO.17.10.107003] and phantom [J. Biomed. Opt.19, 077002 (2014)JBOPFO1083-366810.1117/1.JBO.19.7.077002] studies to accurately extract optical properties and the top layer thickness of a two-layered superficial tissue model from diffuse reflectance spectroscopy (DRS) data. This paper describes a hybrid two-step parameter estimation procedure to address two main issues of the previous method, including (1) high computational intensity and (2) converging to local minima...
April 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29675101/a-network-meta-analysis-comparing-the-efficacy-and-safety-of-anti-pd-1-with-anti-pd-l1-in-non-small-cell-lung-cancer
#4
Wei You, Mei Liu, Ji-Dong Miao, Yu-Qian Liao, Yi-Bing Song, Dian-Kun Cai, Yang Gao, Hao Peng
Background : This network meta-analysis aimed at comparing anti-programmed death 1 (anti-PD-1) with anti-programmed death ligand 1(anti-PD-L1) immunotherapy in patients with metastatic, previously treated non-small cell lung cancer (NSCLC) who failed first-line treatment. Methods : We searched electronic databases to identify all eligible clinical trials. End-points included overall survival (OS), progression-free survival (PFS) and objective response. Hazard ratios (HRs) or odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were extracted...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29661291/hemodialysis-patients-have-worse-outcomes-after-infrageniculate-revascularization-procedures
#5
Caitlin W Hicks, Joseph K Canner, Kevin Kirkland, Mahmoud B Malas, James H Black, Christopher J Abularrage
BACKGROUND: Hemodialysis (HD) has been shown to be an independent predictor of poor outcomes after femoropopliteal revascularization procedures in patients with chronic limb-threatening ischemia. However, HD patients tend to have isolated infrageniculate disease, an anatomic risk factor for inferior patency. We aimed to compare outcomes for HD versus non-HD patients after infrageniculate open lower extremity bypass (LEB) and endovascular peripheral vascular interventions (PVIs). METHODS: Data from the Society for Vascular Surgery Vascular Quality Initiative database (2008-2014) were analyzed...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29652612/quiet-ego-self-regulatory-skills-and-perceived-stress-in-college-students
#6
Heidi A Wayment, Keragan Cavolo
OBJECTIVE: Examine the unique contributions of self-control and grit subscales (perseverance, interest consistency) as potential mediators of the relationship between quiet ego characteristics and less perceived stress in college students. PARTICIPANTS: Data from 1117 college students were collected between October, 2015 and May, 2016. METHODS: The sample was split randomly into exploratory and confirmatory samples. Multiple mediator models were tested with PROCESS module (SPSS v...
April 13, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29616905/low-cancer-risk-of-south-asians-a-brief-report
#7
H Nicole Tran, Natalia Udaltsova, Yan Li, Arthur L Klatsky
CONTEXT: South Asians (ancestry in India, Pakistan, Bangladesh, or Sri Lanka) may have lower cancer risk than other racial-ethnic groups. OBJECTIVE: To supplement published cohort data suggesting low cancer risk in South Asians. DESIGN: Logistic regression models with 7 covariates to study cancer mortality through 2012 in 273,843 persons (1117 South Asians) with baseline examination data from 1964 to 1985. MAIN OUTCOME MEASURE: Cancer mortality...
March 2, 2018: Permanente Journal
https://www.readbyqxmd.com/read/29595205/correction-a-high-quality-liquid-type-quantum-dot-white-light-emitting-diode
#8
Chin-Wei Sher, Chih-Hao Lin, Huang-Yu Lin, Chien-Chung Lin, Che-Hsuan Huang, Kuo-Ju Chen, Jie-Ru Li, Kuan-Yu Wang, Hsien-Hao Tu, Chien-Chung Fu, Hao-Chung Kuo
Correction for 'A high quality liquid-type quantum dot white light-emitting diode' by Chin-Wei Sher et al., Nanoscale, 2016, 8, 1117-1122.
March 29, 2018: Nanoscale
https://www.readbyqxmd.com/read/29588661/enhancing-the-catalytic-activity-of-a-novel-gh5-cellulase-gt-cel5-from-gloeophyllum-trabeum-cbs-900-73-by-site-directed-mutagenesis-on-loop-6
#9
Fei Zheng, Tao Tu, Xiaoyu Wang, Yuan Wang, Rui Ma, Xiaoyun Su, Xiangming Xie, Bin Yao, Huiying Luo
Background: Cellulases of glycosyl hydrolase (GH) family 5 share a (β/α)8 TIM-barrel fold structure with eight βα loops surrounding the catalytic pocket. These loops exposed on the surface play a vital role in protein functions, primarily due to the interactions of some key amino acids with solvent and ligand molecules. It has been reported that motions of these loops facilitate substrate access and product release, and loops 6 and 7 located at the substrate entrance of the binding pocket promote proton transfer reaction at the catalytic site motions...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29580585/corrigendum-to-dna-triple-helices-biological-consequences-and-therapeutic-potential-biochimie-90-8-2008-1117-1130
#10
Aklank Jain, Guliang Wang, Karen M Vasquez
No abstract text is available yet for this article.
March 23, 2018: Biochimie
https://www.readbyqxmd.com/read/29534529/functional-analysis-of-maize-silk-specific-zmbzip25-promoter
#11
Wanying Li, Dan Yu, Jingjuan Yu, Dengyun Zhu, Qian Zhao
ZmbZIP25 ( Zea mays bZIP (basic leucine zipper) transcription factor 25) is a function-unknown protein that belongs to the D group of the bZIP transcription factor family. RNA-seq data showed that the expression of ZmbZIP25 was tissue-specific in maize silks, and this specificity was confirmed by RT-PCR (reverse transcription-polymerase chain reaction). In situ RNA hybridization showed that ZmbZIP25 was expressed exclusively in the xylem of maize silks. A 5' RACE (rapid amplification of cDNA ends) assay identified an adenine residue as the transcription start site of the ZmbZIP25 gene...
March 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29534229/ceramide-1-phosphate-has-protective-properties-against-cyclophosphamide-induced-ovarian-damage-in-a-mice-model-of-premature-ovarian-failure
#12
Natalia Pascuali, Leopoldina Scotti, Mariana Di Pietro, Gonzalo Oubiña, Diana Bas, María May, Antonio Gómez Muñoz, Patricia S Cuasnicú, Débora J Cohen, Marta Tesone, Dalhia Abramovich, Fernanda Parborell
STUDY QUESTION: Is ceramide-1-phosphate (C1P) an ovarian protective agent during alkylating chemotherapy? SUMMARY ANSWER: Local administration of C1P drastically reduces ovarian damage induced by cyclophosphamide (Cy) via protection of follicular reserve, restoration of hormone levels, inhibition of apoptosis and improvement of stromal vasculature, while protecting fertility, oocyte quality and uterine morphology. WHAT IS KNOWN ALREADY: Cancer-directed therapies cause accelerated loss of ovarian reserve and lead to premature ovarian failure (POF)...
May 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29501368/-a-novel-agent-in-the-treatment-of-heart-failure-with-depressed-systolic-function
#13
Yan C Duarte Vera, Silvia V Cáceres Vinueza, Jorge E Daher Nader, Joffre F Lara Terán
INTRODUCTION: A review is presented on the evolution of the pharmacological treatment of heart failure (HF) in the last 25 years, from the concept of treatment with vasodilators to the blocking or inhibition of the renin angiotensin aldosterone system. Beta-adrenergic inhibition and its important contribution in the reduction of morbidity and mortality due to HF will be discussed along with the role of the natriuretic peptides. One of the most important studies in the cardiology area, and specifically in the management of HF, is presented, in which an approach is demonstrated of the modulator of the neurohumoral systems that are activated in these patients...
February 28, 2018: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29499726/varicella-zoster-virus-vaccination-in-immunosuppressed-children-with-rheumatic-diseases-using-a-pre-vaccination-check-list
#14
Fabian Speth, Claas H Hinze, Susanne Andel, Thomas Mertens, Johannes-Peter Haas
BACKGROUND: The goal of this study was to apply the varicella zoster virus (VZV) vaccine to patients with pediatric rheumatic diseases (PRD) at risk for severe chickenpox, without interrupting their current immunosuppression, including biological agents, using an immunological-based pre-vaccination checklist to assure safety. A pre-vaccination checklist was implemented to ensure adequate immune competence prior to immunization. METHODS: This prospective study included seronegative patients (VZV-IgG ≤200 mIU/ml) and patients who had previously received only a single dose of VZV vaccine...
March 2, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29472194/paediatric-overdiagnosis-modelled-by-coronary-abnormality-trends-in-kawasaki-disease
#15
Eric R Coon, Jacob Wilkes, Susan L Bratton, Rajendu Srivastava
OBJECTIVE: Compare trends in coronary artery (CA) abnormality diagnoses to trends in adverse cardiac outcomes among American children with Kawasaki disease (KD) to assess the fit of detection of CA abnormalities to an established model of overdiagnosis. DESIGN: Multicenter retrospective cohort. SETTING: 48 US children's hospitals in the Paediatric Health Information System database. PARTICIPANTS: Children <18 years receiving care for KD between 2000 and 2014...
February 22, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29460643/para-ovarian-adrenal-rest-tumors-gynecologic-manifestations-of-untreated-congenital-adrenal-hyperplasia
#16
Jessica M Sisto, Fong W Liu, Mitchell E Geffner, Michael L Berman
Congenital adrenal hyperplasia (CAH) is an inherited disorder of adrenal steroidogenesis often diagnosed in infancy. Gynecologists may encounter adult patients with CAH due to the clinical effects of increased androgens, e.g. hirsutism, clitoromegaly, oligomenorrhea, or, rarely, pelvic masses. This case report reviews the association of para-ovarian adrenal rest tumors with CAH, and the role of gynecologists in their evaluation and treatment. A 23-year-old woman with CAH (21-hydroxyase deficiency) untreated for the past 5 years presented with a pelvic mass and elevated serum testosterone (1433 ng/dL) and plasma ACTH (1117 pg/mL)...
February 20, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29460511/tissue-perfusion-rate-estimation-with-compression-based-photoacoustic-ultrasound-imaging-erratum
#17
Min Choi, A M James Shapiro, Roger Zemp
This erratum corrects errors with the figure citations in https://doi.org/10.1117/1.JBO.23.1.016010.
February 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29397810/-ultrastructure-and-raman-spectral-characteristics-of-two-kinds-of-acute-myeloid-leukemia-cells
#18
Hao-Yue Liang, Xue-Lian Cheng, Shu-Xu Dong, Shi-Xuan Zhao, Ying Wang, Yong-Xin Ru
OBJECTIVE: To investigate the Raman spectral characteristics of leukemia cells from 4 patients with acute promyelocytic leukemia (M3 ) and 3 patients with acute monoblastic leukemia (M5 ), establish a novel Raman label-free method to distinguish 2 kinds of acute myeloid leukemia cells so as to provide basis for clinical research. METHODS: Leukemia cells were collected from bone marrow of above-mentioned patients. Raman spectra were acquired by Horiba Xplora Raman spectrometer and Raman spectra of 30-50 cells from each patient were recorded...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29396165/sustainability-of-a-nurse-driven-early-progressive-mobility-protocol-and-patient-clinical-and-psychological-health-outcomes-in-a-neurological-intensive-care-unit
#19
Kate E Klein, James F Bena, Malissa Mulkey, Nancy M Albert
OBJECTIVES: To determine sustainable impact of an early progressive mobility protocol on mobility level and clinical outcomes. DESIGN/METHODS: Prospective, longitudinal, comparative study using three time points (pre-, immediate post-intervention and 12-month post-intervention sustainability). Analyses included comparative statistics and multivariable modelling. Data were collected by clinical nurses, from administrative databases. Psychological health data were collected using a valid, reliable tool...
April 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29370759/identification-of-gossypium-hirsutum-long-non-coding-rnas-lncrnas-under-salt-stress
#20
Fenni Deng, Xiaopei Zhang, Wei Wang, Rui Yuan, Fafu Shen
BACKGROUND: Long non-coding RNAs (lncRNAs) represent a class of riboregulators that either directly act in long form or are processed into shorter microRNAs (miRNAs) and small interfering RNAs. Long noncoding RNAs (lncRNAs) are arbitrarily defined as RNA genes larger than 200 nt in length that have no apparent coding potential. lncRNAs have emerged as playing important roles in various biological regulatory processes and are expressed in a more tissue-specific manner than mRNA. Emerging evidence shows that lncRNAs participate in stress-responsive regulation...
January 25, 2018: BMC Plant Biology
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