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https://www.readbyqxmd.com/read/28696446/inhibitors-or-toxins-large-library-target-specific-screening-of-fullerene-based-nanoparticles-for-drug-design-purpose
#1
Lucky Ahmed, Bakhtiyor Rasulev, Supratik Kar, Paweł Krupa, Magdalena A Mozolewska, Jerzy Leszczynski
Fullerene-based nanoparticles have been the subject of vital interest due to their unique properties and potential application in many areas, including medicine. Here we explore their characteristics that could make them prospective leads for known disease-related proteins. High-throughput virtual screening supported by comprehensive multi-software protein-ligand docking simulation and cheminformatics approaches has been applied in investigation of interactions of 1117 proteins with a 169 fullerene nanoparticles decorated with different small molecules...
July 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28633642/prediction-and-analysis-of-three-gene-families-related-to-leaf-rust-puccinia-triticina-resistance-in-wheat-triticum-aestivum-l
#2
Fred Y Peng, Rong-Cai Yang
BACKGROUND: The resistance to leaf rust (Lr) caused by Puccinia triticina in wheat (Triticum aestivum L.) has been well studied over the past decades with over 70 Lr genes being mapped on different chromosomes and numerous QTLs (quantitative trait loci) being detected or mapped using DNA markers. Such resistance is often divided into race-specific and race-nonspecific resistance. The race-nonspecific resistance can be further divided into resistance to most or all races of the same pathogen and resistance to multiple pathogens...
June 20, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28612039/erratum-large-field-of-view-optical-elastography-using-digital-image-correlation-for-biological-soft-tissue-investigation-erratum
#3
Daniel Claus, Marijo Mlikota, Jonathan Geibel, Thomas Reichenbach, Giancarlo Pedrini, Johannes Mischinger, Siegfried Schmauder, Wolfgang Osten
[This corrects the article DOI: 10.1117/1.JMI.4.1.014505.].
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28608624/four-case-reports-of-chinese-cystic-fibrosis-patients-and-literature-review
#4
Juan Xu, Yong Yin, Lei Zhang, Jing Zhang, Shuhua Yuan, Hao Zhang
AIM: Cystic fibrosis (CF) is an extremely rare disease in Asians. Here, we report four Chinese children with CF and review the literature about Chinese CF patients. METHODS: The cystic fibrosis transmembrane conductance regulator (CFTR) gene testing was performed on four suspected patients for CF screening. We also reviewed the literature about Chinese CF patients from 1970s. The clinical data of all these CF patients were summarized. RESULTS: We diagnosed four CF patients who had mutations in the CFTR gene...
June 13, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28586207/primadorac-a-free-web-interface-for-the-assignment-of-partial-charges-chemical-topology-and-bonded-parameters-in-organic-or-drug-molecules
#5
Piero Procacci
We present PrimaDORAC, a simple and freely accessible web interface for generating the topology and the parameter files of organic or drug molecules to be used in molecular mechanics or molecular dynamics calculations. The interface relies on our in-house FORTRAN90 parser, working on the recently released Generalized Amber Force Field parameter set (GAFF2). AM1/BCC charges are computed using the Public Domain MOPAC7 program and the bond charge corrections (BCC) reported in Jakalian, A.; Jack, D. B.; Bayly, C...
June 14, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28545453/genome-wide-methylation-analysis-reveals-differentially-methylated-loci-that-are-associated-with-an-age-dependent-increase-in-bovine-fibroblast-response-to-lps
#6
Filiz T Korkmaz, David E Kerr
BACKGROUND: Differences in DNA methylation are known to contribute to the development of immune-related disorders in humans but relatively little is known about how methylation regulates immune function in cattle. Utilizing whole-transcriptome analyses of bovine dermal fibroblasts, we have previously identified an age and breed-dependent up-regulation of genes within the toll-like receptor 4 (TLR4) pathway that correlates with enhanced fibroblast production of IL-8 in response to lipopolysaccharide (LPS)...
May 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28538377/time-distribution-of-injury-related-in-hospital-mortality-in-a-trauma-referral-center-in-south-of-iran-2010-2015
#7
Hamidreza Abbasi, Shahram Bolandparvaz, Mahnaz Yadollahi, Mehrdad Anvar, Zahra Farahgol
In Iran, there are no studies addressing trauma death timing and factors affecting time of death after injuries. This study aimed to examine time distribution of trauma deaths in an urban major trauma referral center with respect to victims' injury characteristics during 2010 to 2015.This was a cross-sectional study of adult trauma-related in-hospital deaths resulting from traffic-related accidents, falls, and violence-related injuries. Information on injury characteristics and time interval between admission and death was extracted from 3 hospital databases...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28474574/cathepsin-f-knockdown-induces-proliferation-and-inhibits-apoptosis-in-gastric-cancer-cells
#8
Ce Ji, Ying Zhao, You-Wei Kou, Hua Shao, Lin Guo, Chen-Hui Bao, Ben-Chun Jiang, Xinying Chen, Jing-Wei Dai, Yu-Xin Tong, Ren Yang, Wei Sun, Qiang Wang
Gastric cancer (GC) is one of the most common cancers in the world. Cathepsin F (CTSF) gene has been recently found toparticipate in the progression of several types of cancer. However, the clinical characters and the function of CTSF in GC as well as its molecular mechanism are not clear. Six GC cell lines, 44 paired adjacent noncancerous and GC tissue samples were used to assess CTSF expression by quantitative polymerase chain reaction (qPCR). We used Lentivirus-Mediated Small Hairpin RNA (Lenti-shRNA) against CTSF to knock down the expression of CTSF in gastric cancer cells...
April 25, 2017: Oncology Research
https://www.readbyqxmd.com/read/28467751/rabies-surveillance-in-the-united-states-during-2015
#9
Meseret G Birhane, Julie M Cleaton, Ben P Monroe, Ashutosh Wadhwa, Lillian A Orciari, Pamela Yager, Jesse Blanton, Andres Velasco-Villa, Brett W Petersen, Ryan M Wallace
OBJECTIVE To describe rabies and rabies-related events occurring during 2015 in the United States. DESIGN Observational study based on passive surveillance data. ANIMALS All animals submitted for rabies testing in the United States during 2015. PROCEDURES State and territorial public health programs provided data on animals submitted for rabies testing in 2015. Data were analyzed temporally and geographically to assess trends in domestic and sylvatic animal rabies cases. RESULTS During 2015, 50 states and Puerto Rico reported 5,508 rabid animals to the CDC, representing an 8...
May 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28431923/sources-of-racial-disparities-in-hiv-prevalence-in-men-who-have-sex-with-men-in-atlanta-ga-usa-a-modelling-study
#10
Steven M Goodreau, Eli S Rosenberg, Samuel M Jenness, Nicole Luisi, Sarah E Stansfield, Gregorio A Millett, Patrick S Sullivan
BACKGROUND: In the USA, men who have sex men (MSM) are at high risk for HIV, and black MSM have a substantially higher prevalence of infection than white MSM. We created a simulation model to assess the strength of existing hypotheses and data that account for these disparities. METHODS: We built a dynamic, stochastic, agent-based network model of black and white MSM aged 18-39 years in Atlanta, GA, USA, that incorporated race-specific individual and dyadic-level prevention and risk behaviours, network attributes, and care patterns...
July 2017: Lancet HIV
https://www.readbyqxmd.com/read/28414355/experimental-study-of-temporal-spatial-binary-pattern-projection-for-3d-shape-acquisition
#11
Pei Zhou, Jiangping Zhu, Xianyu Su, Zhisheng You, Hailong Jing, Chao Xiao, Min Zhong
Three-dimensional (3D) acquisition of an object with modest accuracy and speed is of particular concern in practice. The performance of digital sinusoidal fringe pattern projection using an off-the-shelf digital video projector is generally discounted by the nonlinearity and low switch rate. In this paper, a binary encoding method to encode one computer-generated standard sinusoidal fringe pattern is presented for circumventing such deficiencies. In previous work [Opt. Eng.54, 054108 (2015)OPEGAR0091-328610...
April 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/28399859/sex-differences-in-healthcare-expenditures-among-adults-with-diabetes-evidence-from-the-medical-expenditure-panel-survey-2002-2011
#12
Joni S Williams, Kinfe Bishu, Clara E Dismuke, Leonard E Egede
BACKGROUND: The evidence assessing differences in medical costs between men and women with diabetes living in the United States is sparse; however, evidence suggests women generally have higher healthcare expenditures compared to men. Since little is known about these differences, the aim of this study was to assess differences in out-of-pocket (OOP) and total healthcare expenditures among adults with diabetes. METHODS: Data were used from 20,442 adults (≥18 years of age) with diabetes from the 2002-2011 Medical Expenditure Panel Survey...
April 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28393742/experience-is-more-important-than-technology-in-paediatric-post-tonsillectomy-bleeding
#13
A D Hinton-Bayre, K Noonan, S Ling, S Vijayasekaran
BACKGROUND: Paediatric tonsillectomy is a common procedure and one of the first skills acquired by surgical trainees. Post-tonsillectomy bleeding is one of the most significant complications. This study examined post-tonsillectomy bleed rates associated with technology and level of surgical experience. METHODS: Data were collected on all tonsillectomies performed by surgical consultants (n = 6) and trainees (n = 10) at affiliated hospitals over a nine-month period...
April 10, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28368743/population-pharmacokinetics-analysis-of-vrc01-an-hiv-1-broadly-neutralizing-monoclonal-antibody-in-healthy-adults
#14
Yunda Huang, Lily Zhang, Julie Ledgerwood, Nicole Grunenberg, Robert Bailer, Abby Isaacs, Kelly Seaton, Kenneth H Mayer, Edmund Capparelli, Larry Corey, Peter B Gilbert
The monoclonal antibody VRC01 targets the CD4 binding site of the human immunodeficiency virus (HIV)-1 envelope. In the clinical study HVTN 104 (NCT02165267), 84 HIV-uninfected adults received multiple-dose intravenous (IV) VRC01 (10, 20, 30 or 40 mg/kg) every 4 or 8 weeks or subcutaneous (SC) VRC01 (5 mg/kg) every 2 weeks, and were followed for 32 weeks. We conducted a population pharmacokinetics (popPK) analysis based on 1117 VRC01 serum concentrations using a 2-compartment PK model with first-order elimination; for SC VRC01 a depot compartment with a first-order absorption rate constant was also included...
July 2017: MAbs
https://www.readbyqxmd.com/read/28365725/carotenoids-database-structures-chemical-fingerprints-and-distribution-among-organisms
#15
Junko Yabuzaki
To promote understanding of how organisms are related via carotenoids, either evolutionarily or symbiotically, or in food chains through natural histories, we built the Carotenoids Database. This provides chemical information on 1117 natural carotenoids with 683 source organisms. For extracting organisms closely related through the biosynthesis of carotenoids, we offer a new similarity search system 'Search similar carotenoids' using our original chemical fingerprint 'Carotenoid DB Chemical Fingerprints'. These Carotenoid DB Chemical Fingerprints describe the chemical substructure and the modification details based upon International Union of Pure and Applied Chemistry (IUPAC) semi-systematic names of the carotenoids...
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28361197/aspirations-expectations-and-delinquency-the-moderating-effect-of-impulse-control
#16
Alissa Mahler, Cortney Simmons, Paul J Frick, Laurence Steinberg, Elizabeth Cauffman
Although prior research finds a robust link between delinquent behavior and expectations, or an adolescent's perceived likelihood of obtaining one's future goals, fewer studies have evaluated aspirations, or the perceived importance of achieving one's goals. In addition, few studies consider how individual traits such as impulsivity affect the degree to which expectations and aspirations motivate or deter delinquent behavior. We contribute to this body of research by evaluating the independent effects of expectations and aspirations, and the aspiration-expectation gap (i...
March 30, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28357979/adsorption-of-as-v-cd-ii-and-pb-ii-in-multicomponent-aqueous-systems-using-activated-carbons
#17
Minna Pirilä Ph D Gerardo Juan Francisco Cruz Cerro Ph D Kaisu Ainassaari Lic Sc Tech Monica Marcela Gómez Ph D Lenka Matějová Ph D Riitta Liisa Keiski Ph D
This paper studies the use of two activated carbon samples made of cocoa pod husk (CPH-AC) and one commercial activatedcarbon sample in the adsorption of As(V), Cd(II) and Pb(II) from multicomponent synthetic solutions and from the Puyango-Tumbes River water, a river located in northwest Peru. The characterization of the activated carbon samples was conducted. The CPH-AC samples exhibited a specific surface area (SBET) between 709 and 1117 m2/g and a pH point of zero charge (pHPZC) between 4.4 ± 0.2 and 5 ± 0...
March 29, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28339685/information-needs-of-generalists-and-specialists-using-online-best-practice-algorithms-to-answer-clinical-questions
#18
David A Cook, Kristi J Sorensen, Jane A Linderbaum, Laurie J Pencille, Deborah J Rhodes
Objective: : To better understand clinician information needs and learning opportunities by exploring the use of best-practice algorithms across different training levels and specialties. Methods: : We developed interactive online algorithms (care process models [CPMs]) that integrate current guidelines, recent evidence, and local expertise to represent cross-disciplinary best practices for managing clinical problems. We reviewed CPM usage logs from January 2014 to June 2015 and compared usage across specialty and provider type...
February 19, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28248333/superresolved-spatially-multiplexed-interferometric-microscopy
#19
José Ángel Picazo-Bueno, Zeev Zalevsky, Javier García, Vicente Micó
Superresolution capability by angular and time multiplexing is implemented onto a regular microscope. The technique, named superresolved spatially multiplexed interferometric microscopy (S2MIM), follows our previously reported SMIM technique [Opt. Express22, 14929 (2014)OPEXFF1094-408710.1364/OE.22.014929, J. Biomed. Opt.21, 106007 (2016)JBOPFO1083-366810.1117/1.JBO.21.10.106007] improved with superresolved imaging. All together, S2MIM updates a commercially available non-holographic microscope into a superresolved holographic one...
March 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28246253/association-between-statin-use-and-ischemic-stroke-or-major-hemorrhage-in-patients-taking-dabigatran-for-atrial-fibrillation
#20
Tony Antoniou, Erin M Macdonald, Zhan Yao, Simon Hollands, Tara Gomes, Mina Tadrous, Muhammad M Mamdani, David N Juurlink
BACKGROUND: Dabigatran etexilate is a prodrug whose absorption is opposed by intestinal P-glycoprotein and which is converted by carboxylesterase to its active form, dabigatran. Unlike other statins, simvastatin and lovastatin are potent inhibitors of P-glycoprotein and carboxylesterase, and might either increase the risk of hemorrhage with dabigatran etexilate or decrease its effectiveness. METHODS: We conducted 2 population-based, nested case-control studies involving Ontario residents 66 years of age and older who started dabigatran etexilate between May 1, 2012, and Mar...
January 9, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
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