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JOURNAL ARTICLE
Victor Schweiger, Davide Di Vece, Victoria L Cammann, Iva Koleva, Michael Würdinger, Thomas Gilhofer, Katja Rajman, Konrad A Szawan, David Niederseer, Rodolfo Citro, Carmine Vecchione, Eduardo Bossone, Sebastiano Gili, Michael Neuhaus, Jennifer Franke, Benjamin Meder, Miłosz Jaguszewski, Michel Noutsias, Maike Knorr, Thomas Jansen, Fabrizio D'Ascenzo, Francesco Bruno, Ovidio De Filippo, Giulio Stefanini, Gianluca Campo, Wojciech Wanha, Sergio Raposeiras Roubin, Wolfgang Dichtl, Dirk von Lewinski, Christof Burgdorf, Behrouz Kherad, Carsten Tschöpe, Annahita Sarcon, Jerold Shinbane, Lawrence Rajan, Guido Michels, Roman Pfister, Alessandro Cuneo, Claudius Jacobshagen, Mahir Karakas, Wolfgang Koenig, Alexander Pott, Philippe Meyer, Marco Roffi, Adrian Banning, Mathias Wolfrum, Florim Cuculi, Richard Kobza, Thomas A Fischer, Tuija Vasankari, K E Juhani Airaksinen, L Christian Napp, Rafal Dworakowski, Philip MacCarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Christina Chan, Paul Bridgman, Daniel Beug, Clément Delmas, Olivier Lairez, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, Ibrahim El-Battrawy, Ibrahim Akin, Karolina Poledniková, Petr Toušek, David E Winchester, Michael Massoomi, Jan Galuszka, Christian Ukena, Gregor Poglajen, Pedro Carrilho-Ferreira, Christian Hauck, Carla Paolini, Claudio Bilato, Yoshio Kobayashi, Ken Kato, Iwao Ishibashi, Toshiharu Himi, Jehangir Din, Ali Al-Shammari, Abhiram Prasad, Charanjit S Rihal, Kan Liu, P Christian Schulze, Matteo Bianco, Lucas Jörg, Hans Rickli, Gonçalo Pestana, Thanh H Nguyen, Michael Böhm, Lars S Maier, Fausto J Pinto, Petr Widimský, Stephan B Felix, Ruediger C Braun-Dullaeus, Wolfgang Rottbauer, Gerd Hasenfuß, Burkert M Pieske, Heribert Schunkert, Monika Budnik, Grzegorz Opolski, Holger Thiele, Johann Bauersachs, John D Horowitz, Carlo Di Mario, William Kong, Mayank Dalakoti, Yoichi Imori, Thomas Münzel, Jeroen J Bax, Thomas F Lüscher, Filippo Crea, Frank Ruschitzka, Jelena R Ghadri, Christian Templin
No abstract text is available yet for this article.
May 8, 2024: European Heart Journal
#22
JOURNAL ARTICLE
Claudio Maffeis, Luca Busetto, Malgorzata Wasniewska, Daniele Di Pauli, Carla Maccora, Andrea Lenzi
PURPOSE: ACTION Teens (NCT05013359) was conducted in 10 countries to identify perceptions, attitudes, behaviors, and barriers to effective obesity care among adolescents living with obesity (ALwO), caregivers of ALwO, and healthcare professionals (HCPs). Here, we report data from participants in Italy. METHODS: The ACTION Teens cross-sectional online survey was completed by 649 ALwO (aged 12- < 18 years), 455 caregivers, and 252 HCPs in Italy in 2021...
May 8, 2024: Eating and Weight Disorders: EWD
#23
REVIEW
Breana R Cervantes, Madeleine Allman, Quenette L Walton, Ernest N Jouriles, Carla Sharp
African American women are at disproportionate risk of experiencing intimate partner violence (IPV) and consistently report more severe and recurrent IPV victimization in comparison to their White and Hispanic counterparts. IPV is more likely to occur in families with children than in couples without children. Parenting in the wake of IPV is a challenging reality faced by many African American women in the United States. Despite the urgent need to support mothers who have survived IPV, there is currently no culturally adapted parenting intervention for African American mothers following exposure to IPV...
2024: Frontiers in Psychology
#24
JOURNAL ARTICLE
Kelly Yoshizaki, Daniela Perroni Frias, Kevin Maier, Juliana Smelan, Aristides Tadeu Correia, Luanda Mara da Silva Oliveira, Luís Fernando Amato-Lourenço, Bruna Tereso Santillo, Carla Máximo Prado, Telma Miyuki Oshiro, Jose Alexandre M Barbuto, Thais Mauad, Mariangela Macchione
The prevalence of fragrances in various hygiene products contributes to their sensorial allure. However, fragrances can induce sensitization in the skin or respiratory system, and the mechanisms involved in this process are incompletely understood. This study investigated the intricate mechanisms underlying the fragrance's effects on sensitization response, focusing on the interplay between CYP450 enzymes, a class of drug-metabolizing enzymes, and the adaptive immune system. Specifically, we assessed the expression of CYP450 enzymes and cytokine profiles in culture of BEAS-2B and mature dendritic cells (mDC) alone or in co-culture stimulated with 2 mM of a common fragrance, cinnamyl alcohol (CA) for 20 h...
May 7, 2024: Journal of Applied Toxicology: JAT
#25
JOURNAL ARTICLE
Xin'nan Zong, Roya Kelishadi, Hae Soon Kim, Peter Schwandt, Tandi E Matsha, Jose G Mill, Carmelo Antonio Caserta, Carla Campos Muniz Medeiros, Anastasios Kollias, Peter H Whincup, Lucia Pacifico, Abel López-Bermejo, Min Zhao, Miaobing Zheng, Bo Xi
Metabolic syndrome (MetS) is becoming prevalent in the pediatric population. The existing pediatric MetS definitions (e.g., the International Diabetes Federation (IDF) definition and the modified National Cholesterol Education Program (NCEP) definition) involve complex cut-offs, precluding fast risk assessment in clinical practice.We proposed a simplified definition for assessing MetS risk in youths aged 6-17 years, and compared its performance with two existing widely used pediatric definitions (the IDF definition, and the NCEP definition) in 10 pediatric populations from 9 countries globally (n = 19,426) using the receiver operating characteristic (ROC) curve analyses...
May 7, 2024: BMC Medicine
#26
EDITORIAL
Tiago Dantas, Carla M C Abreu, Maria J G De-Castro, Ana Rita Grosso, Joao de Sousa Valente, Gabriela da Silva Xavier
No abstract text is available yet for this article.
May 7, 2024: Communications Biology
#27
JOURNAL ARTICLE
Carla Gabriela Fernandes da Silva, Flávio Santos Lopes, Álissy Fernanda Cardoso Vieira Valois, Cláudia Vieira Prudêncio
The influence of environmental factors on Salmonella sensitivity to nisin in vitro and in refrigerated orange juice were investigated. Nisin activity was observed in the different conditions, but the highest efficiency was achieved at lower pH (4.0) and with higher bacteriocin concentration (174 µM). Moreover, the bactericidal action was directly proportional to the incubation period. When tested in orange juice, nisin caused a reduction of up to 4.05 logarithm cycles in the Salmonella population...
May 7, 2024: FEMS Microbiology Letters
#28
EDITORIAL
Jason Grebely, Carla Treloar
No abstract text is available yet for this article.
May 6, 2024: International Journal on Drug Policy
#29
REVIEW
Beleke de Zwart, Carla Ruis
PURPOSE: Mapping higher-order cognitive functions during awake brain surgery is important for cognitive preservation which is related to postoperative quality of life. A systematic review from 2018 about neuropsychological tests used during awake craniotomy made clear that until 2017 language was most often monitored and that the other cognitive domains were underexposed (Ruis, J Clin Exp Neuropsychol 40(10):1081-1104, 218). The field of awake craniotomy and cognitive monitoring is however developing rapidly...
May 7, 2024: Acta Neurochirurgica
#30
JOURNAL ARTICLE
Michele Fusaroli, Francesco Salvo, Bernard Begaud, Thamir M AlShammari, Andrew Bate, Vera Battini, Andreas Brueckner, Gianmario Candore, Carla Carnovale, Salvatore Crisafulli, Paola Maria Cutroneo, Charles Dolladille, Milou-Daniel Drici, Jean-Luc Faillie, Adam Goldman, Manfred Hauben, Maria Teresa Herdeiro, Olivia Mahaux, Katrin Manlik, François Montastruc, Yoshihiro Noguchi, G Niklas Norén, Roberta Noseda, Igho J Onakpoya, Antoine Pariente, Elisabetta Poluzzi, Myriam Salem, Daniele Sartori, Nhung T H Trinh, Marco Tuccori, Florence van Hunsel, Eugène van Puijenbroek, Emanuel Raschi, Charles Khouri
In pharmacovigilance, disproportionality analyses based on individual case safety reports are widely used to detect safety signals. Unfortunately, publishing disproportionality analyses lacks specific guidelines, often leading to incomplete and ambiguous reporting, and carries the risk of incorrect conclusions when data are not placed in the correct context. The REporting of A Disproportionality analysis for drUg Safety signal detection using individual case safety reports in PharmacoVigilance (READUS-PV) statement was developed to address this issue by promoting transparent and comprehensive reporting of disproportionality studies...
May 7, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
#31
JOURNAL ARTICLE
Michele Fusaroli, Francesco Salvo, Bernard Begaud, Thamir M AlShammari, Andrew Bate, Vera Battini, Andreas Brueckner, Gianmario Candore, Carla Carnovale, Salvatore Crisafulli, Paola Maria Cutroneo, Charles Dolladille, Milou-Daniel Drici, Jean-Luc Faillie, Adam Goldman, Manfred Hauben, Maria Teresa Herdeiro, Olivia Mahaux, Katrin Manlik, François Montastruc, Yoshihiro Noguchi, G Niklas Norén, Roberta Noseda, Igho J Onakpoya, Antoine Pariente, Elisabetta Poluzzi, Myriam Salem, Daniele Sartori, Nhung T H Trinh, Marco Tuccori, Florence van Hunsel, Eugène van Puijenbroek, Emanuel Raschi, Charles Khouri
BACKGROUND AND AIM: Disproportionality analyses using reports of suspected adverse drug reactions are the most commonly used quantitative methods for detecting safety signals in pharmacovigilance. However, their methods and results are generally poorly reported in published articles and existing guidelines do not capture the specific features of disproportionality analyses. We here describe the development of a guideline (REporting of A Disproportionality analysis for drUg Safety signal detection using individual case safety reports in PharmacoVigilance [READUS-PV]) for reporting the results of disproportionality analyses in articles and abstracts...
May 7, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
#32
JOURNAL ARTICLE
Carlos Cruz-Montecinos, María Moena-León, Antonio Durán-Ovalle, Aracelli Lizama-Jofré, Verónica Soto, Andrés Oyarzún, Claudio Tapia, Sandro R Freitas, Ronei S Pinto, Rodrigo Núñez-Cortés, Carla Daffunchio
INTRODUCTION: Regular assessment of motor impairments is crucial in people with haemophilic arthropathy (PwHA). This study aimed to determine if there are differences in 30-seconds sit-to-stand (30-STS) power and maximal voluntary isometric contraction (MVIC) of the knee extensors between PwHA and healthy control group (CG). The secondary aims were to investigate the correlation between 30-STS power and MVIC of knee extensors with clinical characteristics and to assess their effectiveness in identifying motor impairment in PwHA...
May 7, 2024: Haemophilia: the Official Journal of the World Federation of Hemophilia
#33
JOURNAL ARTICLE
Stephan Pribitzer, Colin O'Rourke, Alyssa Ylescupidez, Megan Smithmyer, Christine Bender, Cate Speake, Sandra Lord, Carla J Greenbaum
BACKGROUND: Essentially all individuals with multiple autoantibodies will develop clinical type 1 diabetes. Multiple AABs and normal glucose tolerance define Stage 1 diabetes; abnormal glucose tolerance defines Stage 2. However, the rate of progression within these stages is heterogeneous, necessitating personalized risk calculators to improve clinical implementation. METHODS: We developed 3 models using TrialNet's Pathway to Prevention data to accommodate the reality that not all risk variables are clinically available...
May 7, 2024: Journal of Clinical Endocrinology and Metabolism
#34
JOURNAL ARTICLE
Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl-Heinz Engel, Paul J Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Ursula Gundert-Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens-Berendsen, Matthew Wright, Romualdo Benigni, Claudia Bolognesi, Kevin Chipman, Eugenia Cordelli, Karin Nørby, Camilla Svendsen, Maria Carfì, Gabriele Gagliardi, Carla Martino, Salvatore Multari, Wim Mennes
The EFSA Panel on Food Additives and Flavourings (FAF) was requested to evaluate the safety of 2-methyl-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)butan-1-one [FL-no: 16.134] as a new flavouring substance, in accordance with Regulation (EC) No 1331/2008. The substance has not been reported to occur naturally and is chemically synthesised. In food, it is intended to be used as a flavouring substance only in chewing gum. The chronic dietary exposure to [FL-no: 16.134] was estimated to be 45 μg/person per day for a 60-kg adult and 28...
May 2024: EFSA journal
#35
JOURNAL ARTICLE
Grace Cotter, Kristina Morreale, Amanda Valdegas, Meghan Fish, Rebecca Beebe, Damion Grasso, Carla Stover, Wan-Ling Tseng
BACKGROUND: Pediatric irritability is a pervasive psychiatric symptom, yet its etiology remains elusive. While trauma exposure may contribute to the development of irritability, empirical research is limited. This study examined the prevalence of irritability among trauma-exposed children, identified factors that differentiate trauma-exposed children with and without irritability, and employed a network analysis to uncover associations between irritability and trauma exposure in the family unit...
May 6, 2024: Journal of Child Psychology and Psychiatry, and Allied Disciplines
#36
JOURNAL ARTICLE
Amanda Dias Tadeu, João Duarte, David Trindade, Pedro Costa, Cátia Venâncio, Isabel Lopes, Vanessa Oliveira, Newton C M Gomes, Adelaide Almeida, Carla Pereira
AIMS: This study aimed to evaluate the efficiency of two phages [VB_VaC_TDDLMA (phage TDD) and VB_VaC_SRILMA (phage SRI)] alone and in a cocktail to control Vibrio alginolyticus in brine shrimp before their administration in larviculture. METHODS AND RESULTS: Phages were isolated from seawater samples and characterized by host spectrum, growth parameters, adsorption rate, genomic analysis and inactivation efficiency. Both phages belong to the Caudoviricetes class and lack known virulence or antibiotic-resistance genes...
May 6, 2024: Journal of Applied Microbiology
#37
JOURNAL ARTICLE
Subrata Jana, Andre Luiz Dyna, Saikat Pal, Shuvam Mukherjee, Isabella Maria Tomaz Bissochi, Sueli Fumie Yamada-Ogatta, Maria Laura Goussain Darido, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Bimalendu Ray, Ligia Carla Faccin-Galhardi, Sayani Ray
Seaweed polysaccharides, particularly sulfated ones, exhibited potent antiviral activity against a wide variety of enveloped viruses, such as herpes simplex virus and respiratory viruses. Different mechanisms of action were suggested, which may range from preventing infection to intracellular antiviral activity, at different stages of the viral cycle. Herein, we generated two chemically engineered sulfated fucans (C303 and C304) from Cystoseira indica by an amalgamated extraction-sulfation procedure using chlorosulfonic acid-pyridine/N,N-dimethylformamide and sulfur trioxide-pyridine/N,N-dimethylformamide reagents, respectively...
August 1, 2024: Carbohydrate Polymers
#38
JOURNAL ARTICLE
José M Silva, Carla Vilela, Ana Violeta Girão, Pedro C Branco, João Martins, Mara G Freire, Armando J D Silvestre, Carmen S R Freire
The growing concerns on environmental pollution and sustainability have raised the interest on the development of functional biobased materials for different applications, including food packaging, as an alternative to the fossil resources-based counterparts, currently available in the market. In this work, functional wood inspired biopolymeric nanocomposite films were prepared by solvent casting of suspensions containing commercial beechwood xylans, cellulose nanofibers (CNF) and lignosulfonates (magnesium or sodium), in a proportion of 2:5:3 wt%, respectively...
August 1, 2024: Carbohydrate Polymers
#39
Stephen E Congly, Mayur Brahmania, Carla S Coffin
INTRODUCTION AND OBJECTIVES: Treatment of chronic hepatitis B (CHB) with nucelos(t)ide analogues (NA) can improve outcomes, but NA treatment is expensive for insurance plans. MATERIALS AND METHODS: The Centers for Medicare & Medicaid Services database was assessed from 2012 to 2021 to assess the use of NA for CHB in patients on Medicaid. Data extracted included the number of claims, units, and costs of each agent stratified by originator and generic. RESULTS: Over the study period, 1...
May 4, 2024: Annals of Hepatology
#40
JOURNAL ARTICLE
Ana R Gomes, Elisiário J Tavares-da-Silva, Saúl C Costa, Carla L Varela, Ana M Abrantes, Ana C Gonçalves, Raquel Alves, Maria F Botelho, Fernanda M F Roleira, Ana S Pires
Cancer continues to be a serious threat to human health worldwide. Lung, prostate and triple-negative breast cancers are amongst the most incident and deadliest cancers. Steroidal compounds are one of the most diversified therapeutic classes of compounds and they were proven to be efficient against several types of cancer. The epoxide function has been frequently associated with anticancer activity, particularly the 1,2-epoxide function. For this reason, three 1,2-epoxysteroid derivatives previously synthesised (EP1, EP2 and EP3) and one synthesised for the first time (oxysteride) were evaluated against H1299 (lung), PC3 (prostate) and HCC1806 (triple-negative breast) cancer cell lines...
May 4, 2024: Biochemical Pharmacology
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