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https://www.readbyqxmd.com/read/28449400/a-novel-implementation-strategy-in-residential-care-settings-to-promote-ebp-direct-care-provider-perceptions-and-development-of-a-conceptual-framework
#1
Susan E Slaughter, Erin Bampton, Daniel F Erin, Carla Ickert, C Allyson Jones, Carole A Estabrooks
BACKGROUND: Innovative approaches are required to facilitate the adoption and sustainability of evidence-based care practices. We propose a novel implementation strategy, a peer reminder role, which involves offering a brief formal reminder to peers during structured unit meetings. AIMS: This study aims to (a) identify healthcare aide (HCA) perceptions of a peer reminder role for HCAs, and (b) develop a conceptual framework for the role based on these perceptions...
April 27, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28448799/isolation-of-antioxidant-phenolics-from-schinopsis-brasiliensis-based-on-a-preliminary-lc-ms-profiling
#2
Clisiane Carla de Souza Santos, Milena Masullo, Antonietta Cerulli, Angela Mari, Charles Dos Santos Estevam, Cosimo Pizza, Sonia Piacente
The phenolic content of the ethanol extract of the stem bark of the Brazilian plant Schinopsis brasiliensis Engl. (Anacardiaceae) has been evaluated together with the antioxidant activity. The good antioxidant activity exhibited in the Trolox Equivalent Antioxidant Capacity (TEAC) assay (TEAC value = 3.04 mg/mL) encouraged us to investigate its constituents. An analytical approach based on LC-ESIMS(n) was applied to rapidly obtain a metabolite profile of the ethanol extract of the stem bark of S. brasiliensis...
April 24, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28448695/long-term-memory-in-older-children-adolescents-and-adults-with-autism-spectrum-disorder
#3
Diane L Williams, Nancy J Minshew, Gerald Goldstein, Carla A Mazefsky
This study extends prior memory reports in autism spectrum disorders (ASD) by investigating memory for narratives after longer recall periods and by examining developmental aspects of narrative memory using a cross-sectional design. Forty-seven older children/adolescents with ASD and 31 youth with typical development (TD) and 39 adults with ASD and 45 TD adults were compared on memory for stories from standardized measures appropriate for each age group at three intervals (immediate, 30 min, and 2 day). Both the youth with and without ASD had difficulty with memory for story details with increasing time intervals...
April 27, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28447343/impact-of-perinatal-exposure-to-sucrose-or-high-fructose-corn-syrup-hfcs-55-on-adiposity-and-hepatic-lipid-composition-in-rat-offspring
#4
Carla R Toop, Beverly S Muhlhausler, Kerin O'Dea, Sheridan Gentili
Perinatal exposure to excess maternal intake of added sugars, including fructose and sucrose, is associated with an increased risk of obesity and type 2 diabetes in adult life. However, it is unknown to what extent the type of sugar and the timing of exposure affect these outcomes. The aim of this study was to determine the impact of exposure to maternal consumption of a 10% w/v beverage containing sucrose or high fructose corn syrup-55 (HFCS-55) during the prenatal and/or suckling periods on offspring at 3 and 12 weeks, utilising a cross-fostering approach in a rodent model...
April 26, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28446885/the-impact-of-inattention-hyperactivity-impulsivity-symptoms-and-executive-functions-on-learning-behaviors-of-children-with-adhd
#5
Carla Colomer, Carmen Berenguer, Belén Roselló, Inmaculada Baixauli, Ana Miranda
Children diagnosed with attention deficit/hyperactivity disorder (ADHD) are at risk of experiencing lower academic achievement compared to their peers without ADHD. However, we have a limited understanding of the mechanisms underlying this association. Both the symptoms of the disorder and the executive functions can negatively influence learning behaviors, including motivation, attitude toward learning, or persistence, key aspects of the learning process. The first objective of this study was to compare different components of learning behaviors in children diagnosed with ADHD and typically developing (TD) children...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28445792/vitamin-d-supplementation-restores-the-blunted-muscle-protein-synthesis-response-in-deficient-old-rats-through-an-impact-on-ectopic-fat-deposition
#6
Audrey Chanet, Jérôme Salles, Christelle Guillet, Christophe Giraudet, Alexandre Berry, Véronique Patrac, Carla Domingues-Faria, Camille Tagliaferri, Katia Bouton, Justine Bertrand-Michel, Miriam Van Dijk, Marion Jourdan, Yvette Luiking, Sjors Verlaan, Corinne Pouyet, Philippe Denis, Yves Boirie, Stéphane Walrand
We investigated the impact of vitamin D deficiency and repletion on muscle anabolism in old rats. Animals were fed a control (1 IU vitamin D3/g, ctrl, n=20) or a vitamin D-depleted diet (VDD; 0 IU, n=30) for 6 months. A subset was thereafter sacrificed in the control (ctrl6) and depleted groups (VDD6). Remaining control animals were kept for 3 additional months on the same diet (ctrl9), while a part of VDD rats continued on a depleted diet (VDD9) and another part was supplemented with vitamin D (5 IU, VDS9)...
April 8, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28445460/polyglutamine-tracts-regulate-beclin-1-dependent-autophagy
#7
Avraham Ashkenazi, Carla F Bento, Thomas Ricketts, Mariella Vicinanza, Farah Siddiqi, Mariana Pavel, Ferdinando Squitieri, Maarten C Hardenberg, Sara Imarisio, Fiona M Menzies, David C Rubinsztein
Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). Age at onset of disease decreases with increasing polyglutamine length in these proteins and the normal length also varies. PolyQ expansions drive pathogenesis in these diseases, as isolated polyQ tracts are toxic, and an N-terminal huntingtin fragment comprising exon 1, which occurs in vivo as a result of alternative splicing, causes toxicity...
April 26, 2017: Nature
https://www.readbyqxmd.com/read/28445437/an-exploratory-study-on-the-influence-of-psychopathological-risk-and-impulsivity-on-bmi-and-perceived-quality-of-life-in-obese-patients
#8
Renata Tambelli, Luca Cerniglia, Silvia Cimino, Giulia Ballarotto, Marinella Paciello, Carla Lubrano, Serena Marchitelli, Lucio Gnessi, Andrea Lenzi
The present study aimed to assess the psychological profiles of adult male and female obese patients, as well as to verify the possible influence of their psychopathological risk and impulsivity on their body mass index (BMI) and perceived quality of life. A total of 64 obese subjects accessing a center for care of their obesity were assessed through anthropometric and psychometric measurements. All anthropometric measures in men were higher than in women, while in turn, women showed higher psychopathological symptoms...
April 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28445433/determinants-of-work-performance-in-workers-with-depression-and-anxiety-a-cross-sectional-study
#9
Ivana Ivandic, Kaloyan Kamenov, Diego Rojas, Gloria Cerón, Dennis Nowak, Carla Sabariego
Depression and anxiety are highly prevalent disorders with an impact on existential aspects of person's life, including employment i.e., work performance (WP). In order to develop appropriate strategies, it is essential to identify determinants of WP. The objective of this study was to identify the built, social, attitudinal and health system-related environmental determinants of WP in workers with anxiety or depression in total (N = 1211) and regarding the level of disability. Hierarchical binary logistic regression was performed on data obtained from implementation of the WHO Model Disability Survey (MDS) in Chile in 2015...
April 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28445410/c-c-coupling-reactions-between-benzofurazan-derivatives-and-1-3-diaminobenzenes
#10
Gabriele Micheletti, Silvia Bordoni, Elena Chugunova, Carla Boga
Aromatic substitution reactions between 1,3-diaminobenzene and chloronitrobenzofurazan derivatives have never been reported so far. The aim of the current study was to synthesize novel electron-donor and -acceptor architectures of interest in applied fields and to provide new insights on the nucleophilic behavior of 1,3-diaminobenzenes. The reaction of 1,3-dipiperidinyl-, 1,3-dimorpholinyl-, 1,3-dipyrrolidinyl-, or 1,3-dimethylamino-benzene with 7-chloro-4,6-dinitrobenzofuroxan or with a series of chloro-nitrobenzofurazans has been carried out in mild conditions...
April 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28445135/micrornas-in-prostate-cancer-an-overview
#11
REVIEW
Daniela Vanacore, Mariarosaria Boccellino, Sabrina Rossetti, Carla Cavaliere, Carmine D'Aniello, Rossella Di Franco, Francesco Jacopo Romano, Micaela Montanari, Elvira La Mantia, Raffaele Piscitelli, Flavia Nocerino, Francesca Cappuccio, Giovanni Grimaldi, Alessandro Izzo, Luigi Castaldo, Maria Filomena Pepe, Maria Gabriella Malzone, Gelsomina Iovane, Gianluca Ametrano, Paola Stiuso, Lucio Quagliuolo, Daniela Barberio, Sisto Perdonà, Paolo Muto, Maurizio Montella, Piera Maiolino, Bianca Maria Veneziani, Gerardo Botti, Michele Caraglia, Gaetano Facchini
Prostate cancer is the second highest cause of cancer mortality after lung tumours. In USA it affects about 2.8 million men and the incidence increases with age in many countries. Therefore, early diagnosis is a very important step for patient clinical evaluation and for a selective and efficient therapy. The study of miRNAs' functions and molecular mechanisms has brought new knowledge in biological processes of cancer. In prostate cancer there is a deregulation of several miRNAs that may function as tumour suppressors or oncogenes...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28444748/identification-of-coagulation-gene-3-utr-variants-that-are-potentially-regulated-by-micrornas
#12
Carla Y Vossen, Astrid van Hylckama Vlieg, Raúl Teruel-Montoya, Salam Salloum-Asfar, Hugoline de Haan, Javier Corral, Pieter Reitsma, Bobby P C Koeleman, Constantino Martínez
MicroRNAs have been recognized as critical regulators of gene expression and might affect the risk of venous thrombosis. We aimed to identify 3' untranslated region (UTR) variants in coagulation genes that influence coagulation factor levels and venous thrombosis risk. The 3'UTR of coagulation genes were sequenced in subjects with extremely high or low plasma levels of these factors in two case-control studies. In total, 28 variants were identified. Five single nucleotide polymorphisms (SNPs) were predominantly present in one extreme level group (F2 rs1799963, F8 rs1050705 and F11 rs4253429, rs4253430 and rs1062547)...
April 26, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28444416/control-of-dna-integrity-in-skeletal-muscle-under-physiological-and-pathological-conditions
#13
REVIEW
Yara Bou Saada, Vlada Zakharova, Boris Chernyak, Carla Dib, Gilles Carnac, Svetlana Dokudovskaya, Yegor S Vassetzky
Skeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement, as well as nutrient and temperature regulation. DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age. Here, we present a summary of data obtained on DNA damage and its implication in muscle homeostasis, myogenic differentiation and neuromuscular disorders. Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health...
April 25, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28444375/evaluation-of-the-alpha-amylase-activity-as-an-indicator-of-pasteurization-efficiency-and-microbiological-quality-of-liquid-whole-eggs
#14
Guilherme Resende da Silva, Liliane Denize Miranda Menezes, Isabela Pereira Lanza, Daniela Duarte de Oliveira, Carla Aparecida Silva, Roger Wilker Tavares Klein, Débora Cristina Sampaio de Assis, Silvana de Vasconcelos Cançado
In order to evaluate the efficiency of the pasteurization process in liquid whole eggs, an UV/visible spectrophotometric method was developed and validated for the assessment of alpha-amylase activity. Samples were collected from 30 lots of raw eggs (n = 30) and divided into three groups: one was reserved for analysis of the raw eggs, the second group was pasteurized at 61.1°C for 3.5 minutes (n = 30), and the third group was pasteurized at 64.4°C for 2.5 minutes (n = 30). In addition to assessing alpha-amylase activity, the microbiological quality of the samples was also evaluated by counting total and thermotolerant coliforms, mesophilic aerobic microorganisms, Staphylococcus spp...
April 24, 2017: Poultry Science
https://www.readbyqxmd.com/read/28444335/incidence-of-iga-vasculitis-in-children-estimated-by-four-source-capture-recapture-analysis-a-population-based-study
#15
Maryam Piram, Carla Maldini, Sandra Biscardi, Nathalie De Suremain, Christine Orzechowski, Emilie Georget, Delphine Regnard, Isabelle Koné-Paut, Alfred Mahr
Objectives.: The aim was to describe the epidemiological characteristics of childhood IgA vasculitis (IgAV) defined by the EULAR/PRINTO/Paediatric Rheumatology European Society criteria in a population-based sample from France and ascertain its incidence over 3 years by a four-source capture-recapture analysis. Methods.: Cases were prospectively collected in Val de Marne county, a suburb of Paris, with 263 874 residents <15 years old. Children with incident IgAV living in this area from 2012 to 2014 were identified by four sources of case notification (emergency departments, paediatrics departments, private-practice paediatricians and general practitioners)...
April 24, 2017: Rheumatology
https://www.readbyqxmd.com/read/28442829/warts-of-the-fingertips-in-a-pediatric-patient-with-type-1-diabetes
#16
Jacqueline T Chan, Teresa Alesia, Carla Z Minutti
No abstract text is available yet for this article.
April 2017: Clinical Diabetes: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/28442471/development-of-organoids-from-mouse-and-human-endometrium-showing-endometrial-epithelium-physiology-and-long-term-expandability
#17
Matteo Boretto, Benoit Cox, Manuel Noben, Nikolai Hendriks, Amelie Fassbender, Heleen Roose, Frédéric Amant, Dirk Timmerman, Carla Tomassetti, Arne Vanhie, Christel Meuleman, Marc Ferrante, Hugo Vankelecom
The endometrium, which is of crucial importance for reproduction, undergoes dynamic cyclic tissue remodeling. Knowledge of its molecular and cellular regulation is poor, primarily owing to a lack of study models. Here, we have established a novel and promising organoid model from both mouse and human endometrium. Dissociated endometrial tissue, embedded in Matrigel under WNT-activating conditions, swiftly formed organoid structures that showed long-term expansion capacity, and reproduced the molecular and histological phenotype of the tissue's epithelium...
April 25, 2017: Development
https://www.readbyqxmd.com/read/28442440/impact-of-dose-and-surface-features-on-plasmatic-and-liver-concentrations-of-biodegradable-polymeric-nanocapsules
#18
Líliam Teixeira Oliveira, Mônica Auxiliadora de Paula, Bruno Mendes Roatt, Giani Martins Garcia, Luan Silvestro Bianchini Silva, Alexandre Barbosa Reis, Carina Silva de Paula, José Mário Carneiro Vilela, Margareth Spangler Andrade, Gwenaelle Pound-Lana, Vanessa Carla Furtado Mosqueira
The effect of polymeric nanocapsule dose on plasmatic and liver concentrations 20min after intravenous administration in mice was evaluated. Nanocapsules were prepared with different polymers, namely, poly(D,L-lactide) (PLA), polyethylene glycol-block-poly(D,L-lactide) (PLA-PEG), and PLA with chitosan (PLA-Cs) and compared with a nanoemulsion. These formulations were labelled with a phthalocyanine dye for fluorescent detection. The nanostructures had narrow size distributions upon separation by asymmetric flow field flow fractionation with static and dynamic light scattering detection, with average hydrodynamic diameters in the 130-300nm range, negative zeta potentials, except PLA-Cs nanocapsules, which had a positive zeta potential...
April 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28442271/evaluation-of-the-xpert-hcv-viral-load-point-of-care-assay-from-venepuncture-collected-and-finger-stick-capillary-whole-blood-samples-a-cohort-study
#19
Jason Grebely, Francois M J Lamoury, Behzad Hajarizadeh, Yasmin Mowat, Alison D Marshall, Sahar Bajis, Philippa Marks, Janaki Amin, Julie Smith, Michael Edwards, Carla Gorton, Nadine Ezard, David Persing, Marika Kleman, Philip Cunningham, Beth Catlett, Gregory J Dore, Tanya L Applegate
BACKGROUND: Point-of-care hepatitis C virus (HCV) RNA testing offers an advantage over antibody testing (which only indicates previous exposure), enabling diagnosis of active infection in a single visit. In this study, we evaluated the performance of the Xpert HCV Viral Load assay with venepuncture and finger-stick capillary whole-blood samples. METHODS: Plasma and finger-stick capillary whole-blood samples were collected from participants in an observational cohort enrolled at five sites in Australia (three drug and alcohol clinics, one homelessness service, and one needle and syringe programme)...
April 21, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28440579/prevalence-of-herpes-simplex-virus-types-1-and-2-at-maternal-and-fetal-sides-of-the-placenta-in-asymptomatic-pregnant-women
#20
Fabiana Finger-Jardim, Emiliana C Avila, Vanusa P da Hora, Carla V Gonçalves, Ana Maria B de Martinez, Marcelo A Soares
PROBLEM: Herpes simplex virus 1 (HSV-1) commonly causes orolabial infection, but can also infect the genital mucosa. In contrast, HSV-2 is usually genital. Genital herpes can transmit the virus vertically to the fetus during pregnancy. We sought to estimate the prevalence of HSV-1/2 on the maternal and fetal sides of the placenta. METHOD OF STUDY: Placental tissues were collected from pregnant women seen at the Rio Grande University Hospital. HSV-1 and HSV-2 were detected by nested PCR...
April 25, 2017: American Journal of Reproductive Immunology: AJRI
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