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Carla Minoia, Sabino Ciavarella, Giovanna Lerario, Antonella Daniele, Simona De Summa, Mariarosaria Napolitano, Attilio Guarini
No abstract text is available yet for this article.
June 21, 2018: Acta Haematologica
Leticia Rojas, Samanta Melgar-Rodríguez, Jaime Díaz-Zúñiga, Carla Alvarez, Gustavo Monasterio, Carolina Rojas, Paola Carvajal, Rolando Vernal
OBJECTIVE: In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on LPS antigenicity. Mixed infection with the different A. actinomycetemcomitans serotypes is frequent in periodontitis patients; accordingly, the role of this bacterial species in the pathogenesis of periodontitis may differ depending whether patients or periodontal lesions harbour one or more of the A. actinomycetemcomitans serotypes. We hypothesized that different combinations of these serotypes could be associated with distinct host responses and hence different inflammatory patterns...
June 12, 2018: Archives of Oral Biology
Nicholas C Firth, Carla M Startin, Rosalyn Hithersay, Sarah Hamburg, Peter A Wijeratne, Kin Y Mok, John Hardy, Daniel C Alexander, André Strydom
Objective: Individuals with Down syndrome (DS) have an extremely high genetic risk for Alzheimer's disease (AD), however, the course of cognitive decline associated with progression to dementia is ill-defined. Data-driven methods can estimate long-term trends from cross-sectional data while adjusting for variability in baseline ability, which complicates dementia assessment in those with DS. Methods: We applied an event-based model to cognitive test data and informant-rated questionnaire data from 283 adults with DS (the largest study of cognitive functioning in DS to date) to estimate the sequence of cognitive decline and individuals' disease stage...
June 2018: Annals of Clinical and Translational Neurology
Séphora Louyse Silva Aquino, Aline Tuane Oliveira da Cunha, Hermilla Torres Pereira, Erika Paula Silva Freitas, Ana Paula Trussardi Fayh, Josivan Gomes Lima, Severina Carla Vieira Cunha Lima, Karine Cavalcanti Maurício Sena-Evangelista, Lucia Fátima Campos Pedrosa
Background: The risk of metabolic syndrome can be influenced by inadequate vitamin D levels, and exposure to sunlight is the main external source of vitamin D. The present study assessed the influence of environmental, biological, and nutritional factors in relation to seasonal 25-hydroxyvitamin D (25OHD) concentration in individuals with metabolic syndrome. Methods: This cross-sectional study enrolled 180 individuals with metabolic syndrome aged between 18 and 80 years...
2018: Diabetology & Metabolic Syndrome
Mara Paneroni, Carla Simonelli, Manuela Saleri, Debora Trainini, Georges Fokom, Ilaria Speltoni, Giancarlo Piaggi, Nicolino Ambrosino, Michele Vitacca
OBJECTIVE: To evaluate the short-term physiologic effects of respiratory muscle training with normocapnic hyperpnea (NH) added to standard exercise training on respiratory muscle endurance/strength and exercise tolerance in COPD patients. DESIGN: Randomized controlled trial. Patients referred for rehabilitation were randomly assigned to 20 sessions (twice daily 5 days/week) of either NH (Group 1, n = 12) or sham maneuvers (Group 2, n = 10) in addition to individualized cycle training and abdominal, upper and lower limb muscle exercise...
June 21, 2018: American Journal of Physical Medicine & Rehabilitation
João Mauricio Castaldelli-Maia, Silvia S Martins, Carla L Storr, Maria C Viana, Laura H Andrade, Arthur G Andrade
We investigated the dimensionality and possible measurement bias of ICD-11 Nicotine Dependence (ND) criteria in a sample of smokers from a middle-income country. Data are from the São Paulo Megacity Project (part of World Mental Health Surveys) collected between 2005 and 2007 (n = 5,037). The current analyses were restricted to the 1,388 participants who smoked at least once a week for 2 months in their lifetime. Item response theory (IRT) was used to investigate the severity and discrimination properties of 8 selected criteria...
June 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
Pietro Cacialli, Antonio Palladino, Carla Lucini
Several mammalian animal models of traumatic brain injury have been used, mostly rodents. However, reparative mechanisms in mammalian brain are very limited, and newly formed neurons do not survive for long time. The brain of adult zebrafish, a teleost fish widely used as vertebrate model, possesses high regenerative properties after injury due to the presence of numerous stem cells niches. The ventricular lining of the zebrafish dorsal telencephalon is the most studied neuronal stem cell niche because its dorso-lateral zone is considered the equivalent to the hippocampus of mammals which contains one of the two constitutive neurogenic niches of mammals...
June 2018: Neural Regeneration Research
Chiara Cosentino, Domenico Sgromo, Carla Merisio, Roberto Berretta, Carlo Pruneti
This study aimed to evaluate the psychological and physiological adjustment in a sample of Ovarian Cancer survivors. For all we know, this is the first time that such analysis has been performed in Italy. We assessed psychological adjustment along with physiological adjustment, measured through the basal Heart Rate Variability at rest. We assessed 38 women overall, aged 29-80 years, in follow up for ovarian cancer. Each participant filled a psycho-oncological record, Multidimensional Scale of Perceived Social Support, Derridford Appearance Scale-59, Mental Adjustment to Cancer and EORTC Quality of Life Questionnaire LQ-30 Version 3...
June 2018: Applied Psychophysiology and Biofeedback
Laura V Danai, Ana Babic, Michael H Rosenthal, Emily A Dennstedt, Alexander Muir, Evan C Lien, Jared R Mayers, Karen Tai, Allison N Lau, Paul Jones-Sali, Carla M Prado, Gloria M Petersen, Naoki Takahashi, Motokazu Sugimoto, Jen Jen Yeh, Nicole Lopez, Nabeel Bardeesy, Carlos Fernandez-Del Castillo, Andrew S Liss, Albert C Koong, Justin Bui, Chen Yuan, Marisa W Welch, Lauren K Brais, Matthew H Kulke, Courtney Dennis, Clary B Clish, Brian M Wolpin, Matthew G Vander Heiden
Malignancy is accompanied by changes in the metabolism of both cells and the organism1,2 . Pancreatic ductal adenocarcinoma (PDAC) is associated with wasting of peripheral tissues, a metabolic syndrome that lowers quality of life and has been proposed to decrease survival of patients with cancer3,4 . Tissue wasting is a multifactorial disease and targeting specific circulating factors to reverse this syndrome has been mostly ineffective in the clinic5,6 . Here we show that loss of both adipose and muscle tissue occurs early in the development of pancreatic cancer...
June 20, 2018: Nature
Christopher P Caridi, Carla D'Agostino, Taehyun Ryu, Grzegorz Zapotoczny, Laetitia Delabaere, Xiao Li, Varandt Y Khodaverdian, Nuno Amaral, Emily Lin, Alesandra R Rau, Irene Chiolo
Heterochromatin mainly comprises repeated DNA sequences that are prone to ectopic recombination. In Drosophila cells, 'safe' repair of heterochromatic double-strand breaks by homologous recombination relies on the relocalization of repair sites to the nuclear periphery before strand invasion. The mechanisms responsible for this movement were unknown. Here we show that relocalization occurs by directed motion along nuclear actin filaments assembled at repair sites by the Arp2/3 complex. Relocalization requires nuclear myosins associated with the heterochromatin repair complex Smc5/6 and the myosin activator Unc45, which is recruited to repair sites by Smc5/6...
June 20, 2018: Nature
Peter S Linsley, Carla J Greenbaum, Mario Rosasco, Scott Presnell, Kevan C Herold, Matthew J Dufort
Biologic treatment of type 1 diabetes (T1D) with agents including anti-CD3 (otelixizumab and teplizumab), anti-CD20 (rituximab), LFA3Ig (alafacept), and CTLA4Ig (abatacept) results in transient stabilization of insulin C-peptide, a surrogate for endogenous insulin secretion. With the goal of inducing more robust immune tolerance, we used systems biology approaches to elucidate mechanisms associated with C-peptide stabilization in clinical trial blood samples from new-onset T1D subjects treated with the B cell-depleting drug, rituximab...
June 21, 2018: Genes and Immunity
Björn Kruspig, Tiziana Monteverde, Sarah Neidler, Andreas Hock, Emma Kerr, Colin Nixon, William Clark, Ann Hedley, Sarah Laing, Seth B Coffelt, John Le Quesne, Craig Dick, Karen Vousden, Carla P Martins, Daniel J Murphy
KRAS is the most frequently mutated driver oncogene in human adenocarcinoma of the lung. There are presently no clinically proven strategies for treatment of KRAS-driven lung cancer. Activating mutations in KRAS are thought to confer independence from upstream signaling; however, recent data suggest that this independence may not be absolute. We show that initiation and progression of KRAS-driven lung tumors require input from ERBB family receptor tyrosine kinases (RTKs): Multiple ERBB RTKs are expressed and active from the earliest stages of KRAS-driven lung tumor development, and treatment with a multi-ERBB inhibitor suppresses formation of KRASG12D -driven lung tumors...
June 20, 2018: Science Translational Medicine
Alessandro Ciresi, Stefano Radellini, Valentina Guarnotta, Maria Grazia Mineo, Carla Giordano
OBJECTIVE: To evaluate the impact of gender on the clinical and metabolic parameters in prepubertal GHD children at diagnosis and during GH treatment (GHT). DESIGN: The data of 105 prepubertal children (61 males, 44 females, mean age 6.8 ± 0.7 years) affected by idiopathic GHD were retrospectively evaluated. METHODS: Body height, BMI, waist circumference (WC), IGF-I, HbA1c, lipid profile, fasting and after-OGTT glucose and insulin levels, insulin sensitivity and secretion indices were evaluated at baseline and after 24 months of GHT...
June 20, 2018: Endocrine Connections
Juliana F Rocha, David S Freitas, Jennifer Noro, Carla Sílvia Silva Teixeira, Cristina E A Sousa, M Jose Alves, Nuno M F Sousa A Cerqueira
The synthesis of a 1,5-lactone 2,4-O-alkylidene-D-erythrose derivative was found to be a highly stereoselective template in Michael addition trough the reaction of a D-erythrosyl 1,5-lactone derivative with nitrogen and sulfur nucleophiles. The sulfur adducts formed are 1 (D-erythrose derivative):1 (nucleophile), and the nitrogen adducts are 1:2. Both were then treated under HCl to give 2,6-dideoxy-4-functionalized-D-ribono-hexono-1,4-lactone by a reaction cascade in high overall yield. Reaction's scale up even improves the yield...
June 20, 2018: Journal of Organic Chemistry
Maila Danielis, Sara Colussi, Carla de Leitenburg, Lluis Soler, Jordi Llorca, Alessandro Trovarelli
By carefully mixing Pd metal nanoparticles with CeO2 polycrystalline powder under dry conditions a new unpredicted arrangement of the Pd-O-Ce interface is obtained, where an amorphous shell containing Palladium species dissolved in Ceria is covering a core of CeO2 particles. The robust contact that is generated at nanoscale, along with mechanical forces generated during mixing, promotes the redox exchange between Pd and CeO2 and creates highly reactive and stable sites constituted by PdOx embedded into CeO2 surface layers...
June 20, 2018: Angewandte Chemie
Natasha Ferreira Santos da Cruz, Larissa Silva Brandão, Sérgio Ferreira Santos da Cruz, Sérgio Augusto Sequeira da Cruz, Carla Andréa Avelar Pires, Francisca Regina Oliveira Carneiro
PURPOSE: We aimed to report the ocular manifestations observed in patients with psoriasis. METHODS: Patients were included and referred to our ophthalmology clinic from dermatology clinics of Universidade do Estado do Pará between October 2013 and August 2014. Clinical interviews were conducted to identify relevant epidemiological data, clinical features, and treatment details, and data were recorded using the same protocol. Subsequent dermatological examinations were performed and disease severity was rated using the Psoriasis Area and Severity Index and the Dermatological Life Quality Index...
June 2018: Arquivos Brasileiros de Oftalmologia
Camilla Ribeiro Lima de Farias, Carla Campos Muniz Medeiros, Diogo Rodrigues Souza, Ivelise Fhrideraid Alves Furtado da Costa, Mônica Oliveira da Silva Simões, Danielle Franklin de Carvalho
OBJECTIVE: to verify persistence of metabolic syndrome (MetS) and components in overweight children and adolescents, as well as its relation to socioeconomic and demographic characteristics and to the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) score. METHOD: a two-point longitudinal study: at enrollment and after a 24-month interval, with 133 individuals ages from two to 18 years. The demographic anthropomorphic and blood variables were evaluated...
May 2018: Revista Brasileira de Enfermagem
Karilena Karlla de Amorim Pedrosa, Suelen Alves de Oliveira, Regimar Carla Machado
OBJECTIVE: to elaborate and validate a protocol for the care of the nurse to the septic patient in Intensive Care Units (ICUs). METHOD: instrument validation study. Two steps were followed: instrument development and content validation according to the Delphi technique. RESULTS: the validation of contents related to the nurse's assistance to the septic patient in intensive care was initially composed of eighteen items analyzed by the evaluators/judges...
May 2018: Revista Brasileira de Enfermagem
Joan Forns, Jordi Sunyer, Raquel Garcia-Esteban, Daniela Porta, Akhgar Ghassabian, Lise Giorgis-Allemand, Tong Gong, Ulrike Gehring, Mette Sørensen, Marie Standl, Dorothee Sugiri, Catarina Almqvist, Ainara Andiarena, Chiara Badaloní, Rob Beelen, Dietrich Berdel, Giulia Cesaroni, Marie-Aline Charles, Kirsten Thorup Eriksen, Marisa Estarlich, Mariana F Fernandez, Anne Forhan, Vincent W V Jaddoe, Michal Korek, Paul Lichtenstein, Aitana Lertxundi, Maria-Jose Lopez-Espinosa, Iana Markevych, Audrey de Nazelle, Ole Raaschou-Nielsen, Mark Nieuwenhuijsen, Rocío Pérez-Lobato, Claire Philippat, Rémy Slama, Carla Mt Tiesler, Frank C Verhulst, Andrea von Berg, Tanja Vrijkotte, Anne-Marie Nybo Andersen, Barbara Heude, Ursula Krämer, Joachim Heinrich, Henning Tiemeier, Francesco Forastiere, Göran Pershagen, Bert Brunekreef, Mònica Guxens
BACKGROUND: Exposure to air pollution during pregnancy may increase attention-deficit/ hyperactivity disorder (ADHD) symptoms in children, but findings have been inconsistent. We aimed to study this association in a collaborative study of eight European population-based birth/child cohorts, including 29,127 mother-child pairs. METHODS: Air pollution concentrations [nitrogen dioxide (NO2) and particulate matter (PM)] were estimated at the birth address by land-use regression models based on monitoring campaigns performed between 2008 and 2011...
June 19, 2018: Epidemiology
Kristina Crothers, Carla V Rodriguez, Robin M Nance, Kathleen Akgun, Shahida Shahrir, Joon Kim, Guy W Soo Hoo, Amir Sharafkhaneh, Heidi M Crane, Amy C Justice
PURPOSE: No prior studies have addressed the performance of electronic health record (EHR) data to diagnose chronic obstructive pulmonary disease (COPD) in people living with HIV (PLWH), in whom COPD could be more likely to be underdiagnosed or misdiagnosed, given the higher frequency of respiratory symptoms and smoking compared with HIV-uninfected (uninfected) persons. METHODS: We determined whether EHR data could improve accuracy of ICD-9 codes to define COPD when compared with spirometry in PLWH vs uninfected, and quantified level of discrimination using the area under the receiver-operating curve (AUC)...
June 20, 2018: Pharmacoepidemiology and Drug Safety
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