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https://www.readbyqxmd.com/read/28238510/piperazines-as-nootropic-agents-new-derivatives-of-the-potent-cognition-enhancer-dm235-carrying-hydrophilic-substituents
#1
Maria Vittoria Martino, Luca Guandalini, Lorenzo Di Cesare Mannelli, Marta Menicatti, Gianluca Bartolucci, Silvia Dei, Dina Manetti, Elisabetta Teodori, Carla Ghelardini, Maria Novella Romanelli
The piperazine ring of the potent nootropic drug DM235 has been decorated with H-bond donor and acceptor groups (CH2OH, CH2OMe, CH2OCOMe, COOEt); the aim was to insert new functional groups, suitable for further chemical manipulation. The influence of these modifications on nootropic activity was assessed by means of the mouse passive avoidance test; some of the newly synthesized molecules (alcohol 7b, acetate 8b and ester 10d) showed interesting in vivo potency. This makes it possible to use these functional groups for adding other residues, in order to increase molecular diversity, or for anchoring a biotin group, to obtain compounds useful to capture the biological target...
February 16, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28238273/a-novel-approach-to-identifying-a-neuroimaging-biomarker-for-patients-with-serious-mental-illness
#2
Alok Madan, J Christopher Fowler, Michelle A Patriquin, Ramiro Salas, Philip R Baldwin, Kenia M Velasquez, Humsini Viswanath, David L Molfese, Carla Sharp, Jon G Allen, Susan Hardesty, John M Oldham, B Christopher Frueh
Serious mental illness (SMI) is disabling, and current interventions are ineffective for many. This exploratory study sought to demonstrate the feasibility of applying topological data analysis (TDA) to resting-state functional connectivity data obtained from a heterogeneous sample of 235 adult inpatients to identify a biomarker of treatment response. TDA identified two groups based on connectivity between the prefrontal cortex and striatal regions: patients admitted with greater functional connectivity between these regions evidenced less improvement from admission to discharge than patients with lesser connectivity between them...
February 27, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28237554/synthesis-and-pharmacological-evaluation-of-pyrazolo-1-5-a-pyrimidin-7-4h-one-derivatives-as-potential-gabaa-r-ligands
#3
Gabriella Guerrini, Giovanna Ciciani, Simona Daniele, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Claudia Martini, Silvia Selleri
The synthesis of a new series of 6-phenyl- and 6-benzylpyrazolo[1,5-a]pyrimidin-7(4H)-ones 2a-g and 3a-g, strictly related to derivatives with pyrazolobenzotriazine (PBT) and pyrazoloquinazoline (PQ) scaffold, was realized. The in vitro GABAA-receptor subtype affinity was evaluated and from preliminary pharmacological studies, compound 3g shows anxiolytic-like effect at 10-30mg/kg.
February 11, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28237552/kinesio-taping-in-dysphonic-patients
#4
Chiara Mezzedimi, Walter Livi, Maria Carla Spinosi
OBJECTIVE: Kinesio taping (KT) is a method of elastic bandaging that produces a biomechanical effect on the organism. This study aims to evaluate its use in dysphonic patients tratment, as integrated part of speech therapy. STUDY DESIGN: Randomized controlled MATERIALS AND METHODS: Fifteen dysphonic patients were given the option to complement the speech therapy treatment with KT (DG1). 15 dysphonic patients suffering from similar conditions (DG2) who underwent traditional speech therapy were the control group...
February 23, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28236693/attachment-style-moderates-theory-of-mind-abilities-in-depression
#5
Katja Koelkebeck, Carla Liedtke, Waldemar Kohl, Judith Alferink, Mariska Esther Kret
INTRODUCTION: Being able to understand other people's emotions and intentions is crucial for social interactions and well-being. Deficits in theory of mind (ToM) functioning hamper this ability and have been observed in depression and other neuropsychiatric disorders. However, results of previous research in depression have been inconclusive, possibly due to the presence of comorbid disorders and the disregarding of other modulating factors. METHODS: Thirty-eight patients with a major depressive disorder (MDD) and forty healthy matched controls were assessed with a ToM task using animated triangles...
February 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28236010/the-comprehensive-icf-core-set-for-head-and-neck-cancer-a-delphi-consensus-survey-among-german-speaking-speech-and-language-therapists
#6
Matthias Engelbarts, Vanessa Schuster, Ulrich Kisser, Carla Sabariego, Marita Stier-Jarmer, Michaela Coenen, Benjamin Philipp Ernst, Sebastian Strieth, Ulrich Harréus, Sven Becker
The "Comprehensive ICF Core Set for Head and Neck Cancer" (ICF-HNC) is an application of the "International Classification of Functioning, Disability and Health" (ICF), representing the characteristic spectrum of issues in patients with head and neck cancer (HNC). Our primary aim was to evaluate which categories of the ICF-HNC are dealt with by speech and language therapists (SLTs) in Germany, Austria, and Switzerland. The secondary aim was to identify outcome measures used by SLTs to measure the categories of the ICF-HNC in clinical practice...
February 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28235602/status-epilepticus-does-not-induce-acute-brain-inflammatory-response-in-the-amazon-rodent-proechimys-an-animal-model-resistant-to-epileptogenesis
#7
REVIEW
Carla A Scorza, Marcia J G Marques, Sérgio Gomes da Silva, Maria G Naffah-Mazzacoratti, Fulvio A Scorza, Esper A Cavalheiro
Mesial temporal lobe epilepsy is a serious brain disorder in adults that is often preceded by an initial brain insult, such as status epilepticus (SE), that after a latent period leads to recurrent seizures. Post-SE models are widely used for studies on epileptogenic processes. Previous findings of our laboratory suggested that the Neotropical rodents Proechimys exhibit endogenous antiepileptogenic mechanisms in post-SE models. Strong body of research supports that SE triggers a rapid and dramatic upregulation of inflammatory mediators and vascular endothelial growth factor (VEGF)...
February 21, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28231600/validation-of-the-36-item-version-of-the-who-disability-assessment-schedule-2-0-whodas-2-0-for-assessing-women-s-disability-and-functioning-associated-with-maternal-morbidity
#8
Carla Silveira, Mary Angela Parpinelli, Rodolfo Carvalho Pacagnella, Carla Betina Andreucci, Carina Robles Angelini, Elton Carlos Ferreira, José Guilherme Cecatti
Objective To validate the translation and adaptation to Brazilian Portuguese of 36 items from the World Health Organizaton Disability Assessment Schedule 2.0 (WHODAS 2.0), regarding their content and structure (construct), in a female population after pregnancy. Methods This is a validation of an instrument for the evaluation of disability and functioning and an assessment of its psychometric properties, performed in a tertiary maternity and a referral center specialized in high-risk pregnancies in Brazil...
February 23, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28231241/hydrocephalus-and-arthrogryposis-in-an-immunocompetent-mouse-model-of-zika-teratogeny-a-developmental-study
#9
Jose Xavier-Neto, Murilo Carvalho, Bruno Dos Santos Pascoalino, Alisson Campos Cardoso, Ângela Maria Sousa Costa, Ana Helena Macedo Pereira, Luana Nunes Santos, Ângela Saito, Rafael Elias Marques, Juliana Helena Costa Smetana, Silvio Roberto Consonni, Carla Bandeira, Vivian Vasconcelos Costa, Marcio Chaim Bajgelman, Paulo Sérgio Lopes de Oliveira, Marli Tenorio Cordeiro, Laura Helena Vega Gonzales Gil, Bianca Alves Pauletti, Daniela Campos Granato, Adriana Franco Paes Leme, Lucio Freitas-Junior, Carolina Borsoi Moraes Holanda de Freitas, Mauro Martins Teixeira, Estela Bevilacqua, Kleber Franchini
The teratogenic mechanisms triggered by ZIKV are still obscure due to the lack of a suitable animal model. Here we present a mouse model of developmental disruption induced by ZIKV hematogenic infection. The model utilizes immunocompetent animals from wild-type FVB/NJ and C57BL/6J strains, providing a better analogy to the human condition than approaches involving immunodeficient, genetically modified animals, or direct ZIKV injection into the brain. When injected via the jugular vein into the blood of pregnant females harboring conceptuses from early gastrulation to organogenesis stages, akin to the human second and fifth week of pregnancy, ZIKV infects maternal tissues, placentas and embryos/fetuses...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28230860/carma2sh-and-ulk2-control-pathogen-associated-molecular-patterns-recognition-in-human-keratinocytes-psoriasis-linked-carma2sh-mutants-escape-ulk2-censorship
#10
Ivan Scudiero, Pellegrino Mazzone, Luca E D'Andrea, Angela Ferravante, Tiziana Zotti, Gianluca Telesio, Gabriele De Rubis, Carla Reale, Maddalena Pizzulo, Shanmugakonar Muralitharan, Pasquale Vito, Romania Stilo
The molecular complexes formed by specific members of the family of CARMA proteins, the CARD domain-containing adapter molecule BCL10 and MALT1 (CBM complex) represent a central hub in regulating activation of the pleiotropic transcription factor NF-κB. Recently, missense mutations in CARMA2sh have been shown to cause psoriasis in a dominant manner and with high penetrancy. Here, we demonstrate that in human keratinocytes CARMA2sh plays an essential role in the signal transduction pathway that connects pathogen-associated molecular patterns recognition to NF-κB activation...
February 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28230494/application-of-tem-techniques-for-the-study-of-vascular-calcification-monitoring-extracellular-vesicles-and-nanogold-immunodetection-of-fetuin-a-grp-and-cd9
#11
Rute Morais, Carla S B Viegas, Dina C Simes, António P A Matos, Anjos L Macedo
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230466/dysregulated-fetuin-mineral-complexes-are-linked-to-vascular-calcification-in-chronic-kidney-disease-the-role-of-gla-rich-protein
#12
Carla S B Viegas, Anjos L Macedo, Rute Morais, Lúcia Santos, António P A Matos, Ana P Silva, Pedro Neves, Dina C Simes
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230095/genetic-diversity-transmission-dynamics-and-drug-resistance-of-mycobacterium-tuberculosis-in-angola
#13
João Perdigão, Sofia Clemente, Jorge Ramos, Pedro Masakidi, Diana Machado, Carla Silva, Isabel Couto, Miguel Viveiros, Nuno Taveira, Isabel Portugal
Tuberculosis (TB) poses a serious public health problem in Angola. No surveillance data on drug resistance is available and nothing is known regarding the genetic diversity and population structure of circulating Mycobacterium tuberculosis strains. Here, we have genotyped and evaluated drug susceptibility of 89 Mycobacterium tuberculosis clinical isolates from Luanda. Thirty-three different spoligotype profiles corresponding to 24 different Shared International Types (SIT) and 9 orphan profiles were detected...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229944/development-and-in-vivo-evaluation-of-an-innovative-hydrochlorothiazide-in-cyclodextrins-in-solid-lipid-nanoparticles-formulation-with-sustained-release-and-enhanced-oral-bioavailability-for-potential-hypertension-treatment-in-pediatrics
#14
Marzia Cirri, Natascia Mennini, Francesca Maestrelli, Paola Mura, Carla Ghelardini, Lorenzo di Cesare Mannelli
An innovative pediatric oral formulation of hydrochlorothiazide (HCT) (2mg/mL), endowed with improved bioavailability and sustained release properties and suitable for the hypertension treatment in pediatric patients, was developed by combining the drug-cyclodextrin complexation and the incorporation of the complex into Solid Lipid Nanoparticles (SLN). Precirol(®)ATO5-based SLN, with two different surfactants (Pluronic(®)F68 and Tween(®)80) loaded with the drug as such or as binary system with hydroxypropyl-beta-cyclodextrin (HPβCd) and sulfobutyl-ether-beta-cyclodextrin (SBEβCd) both as physical mixture (P...
February 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28229617/giant-esophageal-diverticulum-as-a-new-clinical-indication-for-endoscopic-gastrostomy
#15
Gonçalo Nunes, Carla Adriana Santos, Jorge Fonseca
Persistent mechanical or functional dysphagia is the most common clinical indication for endoscopic gastrostomy (PEG), however less common conditions may justify prolonged enteral feeding to avoid malnutrition and prevent aspiration. The authors report the case of a 76 year old man referred to the artificial feeding outpatient clinic presenting dysphagia, malnutrition and several episodes of aspiration pneumonia. Upper endoscopy showed a giant esophageal diverticulum, ineffective peristalsis and transient lumen narrowing...
February 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28228627/orthodontic-archwire-composition-and-phase-analyses-by-neutron-spectroscopy
#16
Kun V Tian, Giulia Festa, Francesco Basoli, Giuseppina Laganà, Antonella Scherillo, Carla Andreani, Patrizio Bollero, Silvia Licoccia, Roberto Senesi, Paola Cozza
Quantitative metallurgical and phase analyses employing neutron diffraction technique were conducted on two as-received commercial rectangular austenitic stainless steel orthodontic archwires, G&H and Azdent, 0.43×0.64 mm (0.017×0.025 inch). Results showed a bi-phase structure containing martensitic phase (45.67% for G&H and 6.62% for Azdent) in addition to the expected metastable austenite. The former may be a strain-induced phase-transformation arising during the cold working process of wire fabrication...
February 22, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28227268/estimation-of-second-phase-insulin-secretion-in-the-zucker-fatty-rat
#17
Micaela Morettini, Francesco Di Nardo, Carla E Cogo, Emanuela Faelli, Sandro Fioretti, Laura Burattini, Piero Ruggeri, Micaela Morettini, Francesco Di Nardo, Carla E Cogo, Emanuela Faelli, Sandro Fioretti, Laura Burattini, Piero Ruggeri, Emanuela Faelli, Sandro Fioretti, Micaela Morettini, Piero Ruggeri, Laura Burattini, Francesco Di Nardo, Carla E Cogo
The purpose of the present study was to test the efficacy of the empiric index SPIR (Second-phase Insulin Release) in the quantification of second-phase insulin secretion in the Zucker Fatty Rat. SPIR index is defined as the area under the curve of insulin between 8 and 90 min after an Intravenous Glucose Tolerance Test (IVGTT). The validation of such index was performed against the second-phase β-cell responsiveness index (Φ2) provided by C-peptide minimal model. To this aim, Φ2 and SPIR were simultaneously computed from IVGTT data, measured in six Zucker fatty rats (ZFR), 7-to-9week-old, and seven age-matched Zucker lean rats (ZLR)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226712/segmentation-of-angiodysplasia-lesions-in-wce-images-using-a-map-approach-with-markov-random-fields
#18
Pedro M Vieira, Bruno Goncalves, Carla R Goncalves, Carlos S Lima, Pedro M Vieira, Bruno Goncalves, Carla R Goncalves, Carlos S Lima, Pedro M Vieira, Carla R Goncalves, Bruno Goncalves, Carlos S Lima
This paper deals with the segmentation of angiodysplasias in wireless capsule endoscopy images. These lesions are the cause of almost 10% of all gastrointestinal bleeding episodes, and its detection using the available software presents low sensitivity. This work proposes an automatic selection of a ROI using an image segmentation module based on the MAP approach where an accelerated version of the EM algorithm is used to iteratively estimate the model parameters. Spatial context is modeled in the prior probability density function using Markov Random Fields...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226284/does-suboccipital-decompression-and-evacuation-of-intraparenchymal-hematoma-improve-neurological-outcome-in-patients-with-spontaneous-cerebellar-hemorrhage
#19
Katharina A M Hackenberg, Andreas W Unterberg, Carla S Jung, Julian Bösel, Silvia Schönenberger, Klaus Zweckberger
OBJECTIVE: Spontaneous cerebellar hemorrhages (SCH) can lead to life-threatening complications with high mortality rates of 20-50%. Although complications of SCH can be prevented by surgical therapy, there is a lack of consensus concerning the optimal surgical technique for evacuating SCH. METHODS: In this retrospective study 85 patients with SCH were divided into four treatment groups: (1) Decompression and Hematoma Evacuation via suboccipital craniectomy and removal of the posterior arch of C1 (DHE)...
February 3, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28226000/efficacy-and-safety-of-a-single-radiofrequency-ablation-of-solid-benign-non-functioning-thyroid-nodules
#20
Roberto Cesareo, Andrea Palermo, Valerio Pasqualini, Carla Simeoni, Alessandro Casini, Giuseppe Pelle, Silvia Manfrini, Giuseppe Campagna, Roberto Cianni
Objective: The objective of our study is to evaluate the clinical outcomes and safety of radiofrequency thermal ablation (RFA) for benign thyroid nodules (BTNs) over a 1-year follow-up. Subjects and methods: This is a monocentric retrospective study. Forty-eight patients with solid, non-functioning BTNs were treated by RFA using a 17G internally cooled electrode. We categorized thyroid nodules as small (≤ 12 mL), medium (12 to 30 mL), or large (over 30 mL). BTNs volume reduction, thyroid function, cosmetic and compressive score changes and side effect evaluation at 6 and 12 months were evaluated...
February 13, 2017: Archives of Endocrinology and Metabolism
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