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https://www.readbyqxmd.com/read/29475102/predictors-of-benzodiazepine-use-in-a-transdiagnostic-sample-of-panic-disorder-social-anxiety-disorder-and-obsessive-compulsive-disorder-patients
#1
Luana D Laurito, Carla P Loureiro, Rafaela V Dias, Paula Vigne, Gabriela B de Menezes, Rafael C Freire, Ulrich Stangier, Leonardo F Fontenelle
We investigated the rates of current and past benzodiazepine (BZD) use in a sample of 102 subjects attending specialized anxiety disorder clinics, including panic disorder (PD; N = 36), social anxiety disorder (SAD; N = 28) and obsessive-compulsive disorder (OCD; N = 38) patients. Almost 56% of the entire sample was using BZDs at the moment of the assessment, and 74.5% described having used them at some point during their lifetimes. The duration of psychiatric treatment and a lifetime history of PD, but not any other "transdiagnostic" measure of severity (such as the Panic and Agoraphobia Scale, the Social Phobia Inventory, the Dimensional Obsessive-Compulsive Scale, the Anxiety Sensitivity Index-36, and the Beck Inventories) were independent risk factors for current prescription of BZDs...
February 9, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29474907/cell-intrinsic-control-of-interneuron-migration-drives-cortical-morphogenesis
#2
Carla G Silva, Elise Peyre, Mohit H Adhikari, Sylvia Tielens, Sebastian Tanco, Petra Van Damme, Lorenza Magno, Nathalie Krusy, Gulistan Agirman, Maria M Magiera, Nicoletta Kessaris, Brigitte Malgrange, Annie Andrieux, Carsten Janke, Laurent Nguyen
Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons...
February 22, 2018: Cell
https://www.readbyqxmd.com/read/29474467/pre-ingestive-selection-capacity-and-endoscopic-analysis-in-the-sympatric-bivalves-mulinia-edulis-and-mytilus-chilensis-exposed-to-diets-containing-toxic-and-non-toxic-dinoflagellates
#3
Jorge M Navarro, John Widdows, Oscar R Chaparro, Alejandro Ortíz, Carla Mellado, Paola A Villanueva
This study investigates the effects of toxic and non-toxic dinoflatellates on two sympatric bivalves, the clam Mulinia edulis and the mussel Mytilus chilensis. Groups of bivalves were fed one of three diets: (i) the toxic paralytic shellfish producing (PSP) Alexandrium catenella + Isochrysis galbana; (ii) the non-toxic Alexandrium affine + Isochrysis galbana and (iii) the control diet of Isochrysis galbana. Several physiological traits were measured, such as, clearance rate, pre-ingestive selection efficiency and particle transport velocity in the gill...
2018: PloS One
https://www.readbyqxmd.com/read/29473996/octopamine-modulates-the-activity-of-motoneurons-related-to-calling-behavior-in-the-gypsy-moth-lymantria-dispar
#4
Paolo Solari, Giorgia Sollai, Carla Masala, Riccardo Maccioni, Roberto Crnjar, Anna Liscia
A morpho-functional investigation of the different neuronal subpopulations projecting through each of the nerves IV to VI emerging bilaterally from the terminal abdominal ganglion (TAG) was correlated with the octopaminergic activity in the ganglion that controls the ovipositor movements associated with calling behavior in the female gypsy moth Lymantria dispar. Tetramethylrodamine-dextran backfills from nerve stumps resulted in a relatively low number of TAG projections, ranging from 12-13 for nerve pair IV, 12-14 for nerve pair V and 8-9 for nerve pair VI...
February 23, 2018: Insect Science
https://www.readbyqxmd.com/read/29473986/riboflavin-induces-metarhizium-spp-to-produce-conidia-with-elevated-tolerance-to-uv-b-and-upregulates-photolyases-laccases-and-polyketide-synthases-genes
#5
Ronaldo A Pereira-Junior, Carla Huarte-Bonnet, Flávia R S Paixão, Donald W Roberts, Christian Luz, Nicolás Pedrini, Éverton K K Fernandes
AIMS: The effect of nutritional supplementation of two Metarhizium species with riboflavin (Rb) during production of conidia was (a) evaluated on conidial tolerance (based on germination) to UV-B radiation and (b) on conidial expression following UV-B irradiation, of enzymes known to be active in photoreactivation, viz., photolyase (Phr), laccase (Lcc) and polyketide synthase (Pks). METHODS AND RESULTS: Metarhizium acridum (ARSEF 324) and Metarhizium robertsii (ARSEF 2575) were grown either on (a) potato dextrose agar medium (PDA), (b) PDA supplemented with 1% yeast extract (PDAY), (c) PDA supplemented with Rb (PDA+Rb), or (d) PDAY supplemented with Rb (PDAY+Rb)...
February 23, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29473768/comparison-of-definitive-intent-finely-fractionated-and-palliative-intent-coarsely-fractionated-radiotherapy-as-adjuvant-treatment-of-feline-microscopic-injection-site-sarcoma
#6
Federica Rossi, Laura Marconato, Silvia Sabattini, Simona Cancedda, Paola Laganga, Vito F Leone, Carla Rohrer Bley
Objectives The aim of this retrospective, bi-institutional study was to evaluate the progression-free interval in a cohort of cats with postoperative microscopic injection-site sarcoma (ISS) treated with two different radiotherapy protocols. Methods Included in the study were cats with ISSs undergoing macroscopic surgical removal and subsequent electron beam radiotherapy treatment with either a finely fractionated protocol (48 or 52.8 Gy over 4 weeks delivered in 12 or 16 fractions) or a coarsely fractionated protocol (36 Gy over 3 weeks administered in six fractions)...
February 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29472989/improving-knowledge-transfer-to-efficaciously-raise-the-level-of-contemporary-treatment-in-heart-failure-interact-in-hf-study-protocol-of-a-mixed-methods-study
#7
Karolien Baldewijns, Sema Bektas, Josiane Boyne, Carla Rohde, Lieven De Maesschalck, Leentje De Bleser, Vincent Brandenburg, Christian Knackstedt, Aleidis Devillé, Sandra Sanders-Van Wijk, Hans-Peter Brunner La Rocca
Heart failure is a complex disease with poor outcome. This complexity may prevent care providers from covering all aspects of care. This could not only be relevant for individual patient care, but also for care organisation. Disease management programmes applying a multidisciplinary approach are recommended to improve heart failure care. However, there is a scarcity of research considering how disease management programme perform, in what form they should be offered, and what care and support patients and care providers would benefit most...
December 2017: International Journal of Care Coordination
https://www.readbyqxmd.com/read/29472557/metformin-exerts-multitarget-antileukemia-activity-in-jak2-v617f-positive-myeloproliferative-neoplasms
#8
João Agostinho Machado-Neto, Bruna Alves Fenerich, Renata Scopim-Ribeiro, Christopher A Eide, Juan Luiz Coelho-Silva, Carlos Roberto Porto Dechandt, Jaqueline Cristina Fernandes, Ana Paula Nunes Rodrigues Alves, Priscila Santos Scheucher, Belinda Pinto Simões, Luciane Carla Alberici, Lorena Lôbo de Figueiredo Pontes, Cristina E Tognon, Brian J Druker, Eduardo Magalhães Rego, Fabiola Traina
The recurrent gain-of-function JAK2V617F mutation confers growth factor-independent proliferation for hematopoietic cells and is a major contributor to the pathogenesis of myeloproliferative neoplasms (MPN). The lack of complete response in most patients treated with the JAK1/2 inhibitor ruxolitinib indicates the need for identifying novel therapeutic strategies. Metformin is a biguanide that exerts selective antineoplastic activity in hematological malignancies. In the present study, we investigate and compare effects of metformin and ruxolitinib alone and in combination on cell signaling and cellular functions in JAK2V617F -positive cells...
February 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29472088/occupational-exposures-during-abdominal-fluoroscopically-guided-interventional-procedures-for-different-patient-sizes-a-monte-carlo-approach
#9
William S Santos, Walmir Belinato, Ana P Perini, Linda V E Caldas, Diego C Galeano, Carla J Santos, Lucio P Neves
In this study we evaluated the occupational exposures during an abdominal fluoroscopically guided interventional radiology procedure. We investigated the relation between the Body Mass Index (BMI), of the patient, and the conversion coefficient values (CC) for a set of dosimetric quantities, used to assess the exposure risks of medical radiation workers. The study was performed using a set of male and female virtual anthropomorphic phantoms, of different body weights and sizes. In addition to these phantoms, a female and a male phantom, named FASH3 and MASH3 (reference virtual anthropomorphic phantoms), were also used to represent the medical radiation workers...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29470387/assessment-of-chitosan-based-hydrogel-and-photodynamic-inactivation-against-propionibacterium-acnes
#10
Maria Lucia Frade, Sarah Raquel de Annunzio, Giovana Maria Fioramonti Calixto, Francesca Damiani Victorelli, Marlus Chorilli, Carla Raquel Fontana
Chitosan (CH) is a biopolymer that exhibits a number of interesting properties such as anti-inflammatory and antibacterial activity and is also a promising platform for the incorporation of photosensitizing agents. This study aimed to evaluate the efficacy of antimicrobial activity of chitosan hydrogel formulation alone and in combination with the methylene blue (MB) associated with antimicrobial photodynamic therapy (aPDT) against planktonic and biofilm phase of Propionibacterium acnes . Suspensions were sensitized with 12...
February 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29470063/prediction-of-19f-nmr-chemical-shifts-for-fluorinated-aromatic-compounds
#11
Carla Saunders, Mohammed B Khaled, Jimmie D Weaver, Dean J Tantillo
Scaling factors are reported for use in predicting 19F NMR chemical shifts for fluorinated (hetero)aromatic compounds with relatively low levels of theory. Our recommended scaling factors were developed using a curated data set of 52 compounds, with 100 individual 19F shifts spanning a range of 153 ppm. With a maximum deviation of 6.5 ppm between experimental and computed shifts, or 4% of the range tested, these scaling factors allow for the assignment of chemical shifts to specific fluorines in multifluorinated aromatics...
February 22, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29469911/new-chiral-amino-alcohol-ligands-for-catalytic-enantioselective-addition-of-diethylzincs-to-aldehydes
#12
Carla Sappino, Alessandra Mari, Agnese Mantineo, Mauro Moliterno, Matteo Palagri, Chiara Tatangelo, Lorenza Suber, Paolo Bovicelli, Alessandra Ricelli, Giuliana Righi
A study aimed at the synthesis and structure optimization of new, efficient, optically active β-amino alcohol ligands with a structure suitable for immobilization on magnetite nanoparticles has been carried out. The optimized homogeneous amino alcohol catalysts 13a and 13b, the chirality of which arises from the Sharpless epoxidation of suitable allyl alcohols, were tested by employing the well-established enantioselective amino alcohol-promoted addition of diethylzinc to benzaldehyde, giving the corresponding benzyl alcohol with nearly quantitative yield and ee = 95%...
February 22, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29469580/the-psychometric-properties-of-the-personality-assessment-inventory-adolescent-s-borderline-features-scale-across-two-high-risk-samples
#13
Amanda Venta, Melissa Magyar, Shabnam Hossein, Carla Sharp
The present study sought to assess the performance of the Borderline Features (BOR) Scale of the adolescent version of the Personality Assessment Inventory (Morey, 2007b) in 2 high-risk samples: inpatient and justice-involved adolescents. This study is the first to evaluate the BOR scale in high-risk adolescent samples, outside the initial standardization studies. Across both samples (NClinical = 327, NForensic = 151), results indicated good internal consistency. Confirmatory factor analysis indicated poor fit of the 4-factor structure proposed by the measure's authors...
February 22, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29469040/long-term-follow-up-and-quantitative-hepatitis-b-surface-antigen-monitoring-in-north-american-chronic-hbv-carriers
#14
Conar R O'Neil, Stephen E Congly, M Sarah Rose, Samuel S Lee, Meredith A Borman, Carmen L Charlton, Carla Osiowy, Mark G Swain, Kelly W Burak, Carla S Coffin
INTRODUCTION: Quantitative hepatitis B surface antigen (qHBsAg) combined with HBV DNA may be useful for predicting chronic hepatitis B (CHB) activity and nucleoside analogue (NA) response. MATERIAL AND METHODS: In this retrospective cohort study we evaluated qHBsAg levels according to CHB disease phase and among patients on treatment. Random effect logistic regression analysis was used to analyze qHBsAg change with time in the NA-treated cohort. RESULTS: 545 CHB carriers [56% M, median age 48 y (IQR 38-59), 73% Asian] had qHBsAg testing...
March 1, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29468527/collaborative-practice-agreement-in-solid-organ-transplantation
#15
Bharath R Ravichandran, Matthew W Gillespie, Tracy M Sparkes, Carla Williams, Stephen T Bartlett, Abdolreza Haririan, Brian M Masters
Background Given the complexity of solid organ transplant recipients, a multidisciplinary approach is required. To promote medication safety and enable providers to focus on the medical and surgical needs of these patients, our department of pharmacy created a collaborative practice agreement between physicians and pharmacists. Through this agreement, credentialed pharmacists are empowered to provide inpatient services including initiation and adjustment of medications through independent review of laboratory results after multidisciplinary rounds...
February 21, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29468212/retinal-pigment-epithelium-changes-in-pediatric-patients-with-glaucoma-drainage-devices
#16
Carla J Osigian, Sara Grace, Maria P Fernandez, Camila V Ventura, Susan Azar, Ta C Chang, Elizabeth Hodapp, Sander R Dubovy, Audina Berrocal
Purpose: Retinal changes secondary to hypotony are usually described as wrinkling or folding of the inner portion of the choroid, the retinal pigment epithelium (RPE), and the outer retinal layers in the macular area due to scleral wall collapse. We describe a new retinal finding in children with suspected hypotony after implantation of Baerveldt Glaucoma Implant (BGI). Observations: Four patients in our series developed significant RPE defects after BGI implant...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29468019/disentangling-population-strategies-of-two-cladocerans-adapted-to-different-ultraviolet-regimes
#17
Carla E Fernández, Melina Campero, Cintia Uvo, Lars-Anders Hansson
Zooplankton have evolved several mechanisms to deal with environmental threats, such as ultraviolet radiation (UVR), and in order to identify strategies inherent to organisms exposed to different UVR environments, we here examine life-history traits of two lineages of Daphnia pulex . The lineages differed in the UVR dose they had received at their place of origin from extremely high UVR stress at high-altitude Bolivian lakes to low UVR stress near the sea level in temperate Sweden. Nine life-history variables of each lineage were analyzed in laboratory experiments in the presence and the absence of sub-lethal doses of UVR (UV-A band), and we identified trade-offs among variables through structural equation modeling (SEM)...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29467039/influence-of-lifestyle-characteristics-and-vdr-polymorphisms-as-risk-factors-for-intervertebral-disc-degeneration-a-case-control-study
#18
Luiz Angelo Vieira, Aline Amaro Dos Santos, Carla Peluso, Caio Parente Barbosa, Bianca Bianco, Luciano Miller Reis Rodrigues
BACKGROUND: Intervertebral disc degeneration (DD) is an important cause of low back pain and its precise aetiology is not fully understood, being attributed to cumulative environmental, biomechanical and genetic effects. The vitamin D plays a key role in regulation of calcium homeostasis and bone mineralization, exerting its biological activities by binding to a high-affinity receptor (VDR). Polymorphisms in VDR gene were previously associated with DD process, however with conflicting results...
February 21, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29466495/monitoring-auditory-cortical-plasticity-in-hearing-aid-users-with-long-latency-auditory-evoked-potentials-a-longitudinal-study
#19
Renata Aparecida Leite, Fernanda Cristina Leite Magliaro, Jeziela Cristina Raimundo, Ricardo Ferreira Bento, Carla Gentile Matas
OBJECTIVE: The objective of this study was to compare long-latency auditory evoked potentials before and after hearing aid fittings in children with sensorineural hearing loss compared with age-matched children with normal hearing. METHODS: Thirty-two subjects of both genders aged 7 to 12 years participated in this study and were divided into two groups as follows: 14 children with normal hearing were assigned to the control group (mean age 9 years and 8 months), and 18 children with mild to moderate symmetrical bilateral sensorineural hearing loss were assigned to the study group (mean age 9 years and 2 months)...
February 19, 2018: Clinics
https://www.readbyqxmd.com/read/29465624/subcortical-grey-matter-structures-in-multiple-sclerosis-what-is-their-role-in-cognition
#20
Álvaro J Cruz-Gómez, Naiara Aguirre, Carla Sanchis-Segura, César Ávila, Cristina Forn
The present study aimed to investigate altered grey matter (GM) and functional connectivity (FC) in deep subcortical areas, such as the thalamus and basal ganglia, and their relationship with cognitive impairment (CI) in multiple sclerosis (MS). Thirty-six patients were neuropsychologically assessed, classified as cognitive preserved (CP) and CI, and were compared with 18 healthy controls. GM atrophy and FC were observed in 10 predefined functional areas of the thalamus and in six of basal ganglia. GM atrophy was prominent in the basal ganglia in CI patients compared with CP MS patients...
February 20, 2018: Neuroreport
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