keyword
https://read.qxmd.com/read/38535715/the-rising-challenge-of-poor-health-literacy-of-patients-with-systemic-sclerosis-preliminary-data-identify-important-unmet-needs-in-an-italian-cohort
#1
JOURNAL ARTICLE
Khadija El Aoufy, Maria Ramona Melis, Paolo Iovino, Stefano Bambi, Chiara Lorini, Guglielmo Bonaccorsi, Ilaria Galetti, Carla Garbagnati, Paola Canziani, Silvia Tonolo, Marco Mitola, Serena Guiducci, Daniel E Furst, Marco Matucci-Cerinic, Laura Rasero, Silvia Bellando-Randone
RATIONALE AND AIM: Health literacy (HL) is pivotal for the successful self-management of chronic diseases. Little HL information is currently available in SSc patients; therefore, the present study aims at evaluating the HL levels in an Italian cohort of SSc patients. METHODS: SSc patients were enrolled with the support of Italian patient associations, from September 2022 to March 2023. Health literacy characteristics were derived from the Health Literacy Scale European Questionnaire-16 (HLS-EU-Q16), consisting of 16 items designed on a four-point Likert scale ranging from "very difficult" to "very easy", and three HL levels were identified: inadequate HL (0-8 score); problematic HL (9-12 score); and sufficient HL (13-16 score)...
March 5, 2024: Nursing Reports
https://read.qxmd.com/read/38535550/concomitant-syndromic-diagnosis-of-mpox-and-other-vesicular-viruses-in-patients-with-skin-and-genital-lesions
#2
JOURNAL ARTICLE
Maria Beatrice Valli, Antonella Vulcano, Martina Rueca, Giulia Matusali, Valentina Mazzotta, Emanuele Nicastri, Enrico Girardi, Carla Fontana, Andrea Antinori, Fabrizio Maggi
The recent multi-country outbreak of the zoonotic monkeypox virus (MPXV) infection in humans without an epidemiological link with endemic areas has raised concerns about the route of transmission. Since the infection spread largely among men who have sex with men who, in most cases, presented primary lesions of the genital and oral mucosa, sexual transmission has been proposed. In the present study, we retrospectively evaluated specimens of vesicular lesions collected from the skin and genital tract of 35 patients (23 positive and 12 negative) presenting at our Institute for monkeypox (mpox) diagnosis by using a novel molecular syndromic vesicular virus panel (VVP) assay...
February 27, 2024: Pathogens
https://read.qxmd.com/read/38535039/differential-effects-of-a-telemonitoring-platform-in-the-development-of-chemotherapy-associated-toxicity-a-randomized-trial-protocol
#3
JOURNAL ARTICLE
Felipe Martínez, Carla Taramasco, Manuel Espinoza, Johanna Acevedo, Carolina Goic, Bruno Nervi
Chemotherapy requires careful monitoring, but traditional follow-up approaches face significant challenges that were highlighted by the COVID-19 pandemic. Hence, exploration into telemonitoring as an alternative emerged. The objective is to assess the impact of a telemonitoring platform that provides clinical data to physicians overseeing solid tumor patients, aiming to enhance the care experience. The methodology outlines a parallel-group randomized clinical trial involving recently diagnosed patients with solid carcinomas preparing for curative intent chemotherapy...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38534803/incidence-of-non-melanoma-skin-cancers-in-salento-southern-italy-a-15-year-retrospective-analysis-from-the-cancer-registry-of-lecce
#4
JOURNAL ARTICLE
Emiliano Sordi, Prisco Piscitelli, Carla Albanese, Anna Melcarne, Anna Tardio, Fabrizio Quarta, Enrico Greco, Alessandro Miani, Andrea Falco, Elisabetta De Matteis, Maurizio Congedo, Adele Civino
BACKGROUND AND OBJECTIVES: Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC) and squamous-cell carcinoma (SCC), as well as a wide range of rare skin tumors. NMSCs is the most frequently diagnosed type of tumor among Caucasians. We aimed at estimating the incidence and mortality of NMSCs in the Salento area (Lecce province, Southern Italy), whose population is assumed to experience heavy and frequent sun exposure due to climatic/environmental factors, both for working and leisure activities...
December 21, 2023: Epidemiologia (Basel)
https://read.qxmd.com/read/38534657/a-cyclam-salt-as-an-antifungal-agent-interference-with-candida-spp-and-cryptococcus-neoformans-mechanisms-of-virulence
#5
JOURNAL ARTICLE
Fátima Cerqueira, Rui Medeiros, Inês Lopes, Carla Campos, Maria Pia Ferraz, Fernando Silva, Luís G Alves, Eugénia Pinto
The importance of fungal infections, particularly those caused by yeasts, is increasing among the medical community. Candida albicans and Cryptococcus neoformans are amongst the high-priority fungal species identified by the World Health Organization (WHO) and are considered in the critical group, while Candida krusei is included in the medium-priority group. The cyclam salt H4 [H2 (4-CF3 PhCH2 )2 Cyclam]Cl4 proved to be active against the growth of these three yeasts, and the aim of this work was to verify its interference with their virulence mechanisms, whether shared or unique...
February 28, 2024: Antibiotics
https://read.qxmd.com/read/38534606/hydrogels-in-cutaneous-wound-healing-insights-into-characterization-properties-formulation-and-therapeutic-potential
#6
REVIEW
Mariana Ribeiro, Marco Simões, Carla Vitorino, Filipa Mascarenhas-Melo
Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amounts of water and the capacity to closely mimic native structures, such as the extracellular matrix, facilitating various cellular processes like proliferation and differentiation. The polymers used in hydrogel formulations exhibit a broad spectrum of properties, allowing them to be classified into two main categories: natural polymers like collagen and chitosan, and synthetic polymers such as polyurethane and polyethylene glycol...
March 8, 2024: Gels
https://read.qxmd.com/read/38534318/nicotinic-acetylcholine-receptors-in-glial-cells-as-molecular-target-for-parkinson-s-disease
#7
REVIEW
Érica Novaes Soares, Ana Carla Dos Santos Costa, Gabriel de Jesus Ferrolho, Rodrigo Portes Ureshino, Bruk Getachew, Silvia Lima Costa, Victor Diogenes Amaral da Silva, Yousef Tizabi
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) is the primary neurotransmitter involved in this disease, but cholinergic imbalance has also been implicated. Current intervention in PD is focused on replenishing central DA, which provides remarkable temporary symptomatic relief but does not address neuronal loss and the progression of the disease...
March 7, 2024: Cells
https://read.qxmd.com/read/38534151/draft-genome-sequence-of-agarivorans-aestuarii-strain-zmcs4-a-putative-cazyme-producing-bacteria-isolated-from-the-marine-brown-algae-cladostephus-spongiosus
#8
JOURNAL ARTICLE
Beatriz Lorente, Carla Cabral, Jorge Frias, João Faria, Duarte Toubarro
We report the draft genome sequence of Agarivorans aestuarii strain ZMCS4, isolated from Cladostephus spongiosus . The assembled genome consists of 4.5 Mbp, comprising 25 contigs and 4,128 coding sequences. This genome will provide insights into further studies on relevant CAZymes involved in the hydrolysis of algal cell walls.
March 27, 2024: Microbiology Resource Announcements
https://read.qxmd.com/read/38534053/beyond-change-scores-employing-an-improved-statistical-approach-to-analyze-the-impact-of-entry-fitness-on-physical-performance-during-british-army-basic-training-in-men-and-women
#9
JOURNAL ARTICLE
Tessa D Maroni, Andrew G Siddall, Carla A Rue, Sarah C Needham-Beck, Faye S Walker, Julie P Greeves, Sophie L Wardle, Anne Fieldhouse, Stephen D Myers, Sam D Blacker
The aim was to use a robust statistical approach to examine whether physical fitness at entry influences performance changes between men and women undertaking British Army basic training (BT). Performance of 2 km run, seated medicine ball throw (MBT) and isometric mid-thigh pull (MTP) were assessed at entry and completion of Standard Entry (SE), Junior Entry-Short (JE-Short), and Junior Entry-Long (JE-Long) training for 2350 (272 women) recruits. Performance change was analyzed with entry performance as a covariate (ANCOVA), with an additional interaction term allowing different slopes for courses and genders (p < 0...
April 2024: Scandinavian Journal of Medicine & Science in Sports
https://read.qxmd.com/read/38533504/interaction-between-peripheral-blood-mononuclear-cells-and-trypanosoma-cruzi-infected-adipocytes-implications-for-treatment-failure-and-induction-of-immunomodulatory-mechanisms-in-adipose-tissue
#10
JOURNAL ARTICLE
Leyllane Rafael Moreira, Ana Carla Silva, Cíntia Nascimento da Costa-Oliveira, Claudeir Dias da Silva-Júnior, Kamila Kássia Dos Santos Oliveira, Diego José Lira Torres, Michelle D Barros, Michelle Christiane D S Rabello, Virginia Maria Barros de Lorena
BACKGROUND/INTRODUCTION: Adipose tissue (AT) has been highlighted as a promising reservoir of infection for viruses, bacteria and parasites. Among them is Trypanosoma cruzi , which causes Chagas disease. The recommended treatment for the disease in Brazil is Benznidazole (BZ). However, its efficacy may vary according to the stage of the disease, geographical origin, age, immune background of the host and sensitivity of the strains to the drug. In this context, AT may act as an ally for the parasite survival and persistence in the host and a barrier for BZ action...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38532828/clinical-characteristics-and-microorganisms-isolated-in-community-acquired-pneumonia-in-the-covid-19-period
#11
JOURNAL ARTICLE
Meritxell Gavalda, Maria Isabel Fullana, Adrià Ferre, Rebecca Rowena Peña, Julen Armendariz, Orla Torrallardona, Aina Magraner, Alejandro Lorenzo, Carles García, Gemma Mut, Lluís Planas, Carla Iglesias, Pablo Fraile-Ribot, Maria Dolores Macia Romero, Melchor Riera, Mercedes García-Gasalla
INTRODUCTION: Community-acquired pneumonia is a leading cause of mortality and hospital admissions. The aetiology remains unknown in 30-65% of the cases. Molecular tests are available for multiple pathogen detection and are under research to improve the causal diagnosis. METHODS: We carried out a prospective study to describe the clinical characteristics and aetiology of community-acquired pneumonia during the COVID-19 pandemic and to assess the diagnostic effectivity of the microbiological tests, including a molecular test of respiratory pathogens (FilmArray™ bioMérieux)...
2024: Canadian Journal of Infectious Diseases & Medical Microbiology
https://read.qxmd.com/read/38532688/board-certified-psychiatric-pharmacists-and-their-potential-role-in-addressing-behavioral-health-workforce-shortages
#12
JOURNAL ARTICLE
Carla D Cobb, Talia Puzantian, Michael Shuman
Board-certified psychiatric pharmacists (BCPPs) are doctorate-level, board-certified experts in managing medications for people living with psychiatric disorders, including substance use disorders. BCPPs work as part of an integrated health care team that provides comprehensive medication management focused on optimizing medication-related outcomes and ensuring the safety of the prescribed medications. The authors describe BCPP education and training, settings in which BCPPs practice, and in what roles. Current policies that limit BCPP involvement in behavioral health care and proposed solutions to support the role of BCPPs in addressing behavioral health workforce shortages are discussed...
March 27, 2024: Psychiatric Services: a Journal of the American Psychiatric Association
https://read.qxmd.com/read/38532527/management-of-vaccinations-in-patients-with-non-hodgkin-lymphoma
#13
REVIEW
Michele Merli, Andrea Costantini, Silvio Tafuri, Davide Fiore Bavaro, Carla Minoia, Erika Meli, Stefano Luminari, Guido Gini
Vaccinations are fundamental tools in preventing infectious diseases, especially in immunocompromised patients like those affected by non-Hodgkin lymphomas (NHLs). The COVID-19 pandemic made clinicians increasingly aware of the importance of vaccinations in preventing potential life-threatening SARS-CoV-2-related complications in NHL patients. However, several studies have confirmed a significant reduction in vaccine-induced immune responses after anti-CD20 monoclonal antibody treatment, thus underscoring the need for refined immunization strategies in NHL patients...
March 26, 2024: British Journal of Haematology
https://read.qxmd.com/read/38531692/treatment-of-extramammary-paget-s-disease-with-imiquimod-in-a-real-life-setting-a-multicenter-retrospective-analysis-in-spain
#14
JOURNAL ARTICLE
Helena Escolà, Beatriz Llombart, Alba Escolà-Rodríguez, Lucía Barchino-Ortiz, Joaquim Marcoval, Inmaculada Alcaraz, Sònia Beà-Ardébol, Agustí Toll, Román Miñano-Medrano, Pedro Rodríguez-Jiménez, María López-Nuñez, Carla Ferrándiz-Pulido, Ane Jaka, Emili Masferrer, Rafael S Aguayo-Ortiz, Mireia Yébenes, Jorge Arandes-Marcocci, Verónica Ruiz-Salas, Lucía Turrión-Merino, Miquel Just, Júlia Sánchez-Schmidt, Lorena Leal, Fátima Mayo-Martínez, Lara Haya-Martínez, Alejandra Sandoval-Clavijo, Giulia Greta Dradi, Yolanda Delgado, Júlia Verdaguer-Faja, Daniel López-Castillo, Ramon M Pujol, Gustavo Deza
BACKGROUND: Topical imiquimod has shown to be an effective treatment for EMPD, although available evidence supporting its use is based on case reports and small series of patients. OBJECTIVES: To investigate the therapeutic outcomes and analyze potential clinico-pathological factors associated with imiquimod response in a large cohort of EMPD patients. METHODS: Retrospective chart review of 125 EMPD patients treated with imiquimod at 20 Spanish tertiary-care hospitals...
March 26, 2024: Clinical and Experimental Dermatology
https://read.qxmd.com/read/38531674/evolution-and-characteristics-of-studies-estimating-attributable-mortality-to-second-hand-smoke-a-systematic-review
#15
JOURNAL ARTICLE
Diana C López-Medina, Cristina Candal-Pedreira, Julia Rey-Brandariz, Carla Guerra-Tort, Guadalupe García, Lucia Martín-Gisbert, Beatriz Casal-Acción, Alberto Ruano-Ravina, Leonor Varela-Lema, Mónica Pérez-Ríos
BACKGROUND: Several studies have estimated the impact of second-hand smoke (SHS) exposure on mortality in the population of different countries. This study aimed to identify and describe studies that have estimated the attributable mortality (AM) associated with SHS exposure in the adult population. METHODS: A literature search was conducted in MEDLINE, EMBASE, Cochrane Library and CINAHL databases up to January 2023. Studies that estimated the AM associated with SHS exposure in the adult population and used a prevalence-dependent method were included...
March 26, 2024: European Journal of Public Health
https://read.qxmd.com/read/38531539/patient-satisfaction-with-ultrasound-whole-body-ct-and-whole-body-diffusion-weighted-mri-for-pre-operative-ovarian-cancer-staging-a-multicenter-prospective-cross-sectional-survey
#16
JOURNAL ARTICLE
Patrícia Pinto, Lil Valentin, Martina Borčinová, Markéta Wiesnerová, Fruhauf Filip, Andrea Burgetova, Martin Masek, Lukas Lambert, Valentina Chiappa, Dorella Franchi, Antonia Carla Testa, Francesca Moro, Giacomo Avesani, Camilla Panico, Sarah Alessi, Paola Pricolo, Raffaella Vigorito, Giuseppina Calareso, Roman Kocian, Jiri Slama, Anna Fagotti, Ailyn Mariela Vidal Urbinati, Mauro Signorelli, Francesca Bertolina, David Cibula, Daniela Fischerova
BACKGROUND: In addition to the diagnostic accuracy of imaging methods, patient-reported satisfaction with imaging methods is important. OBJECTIVE: To report a secondary outcome of the prospective international multicenter Imaging Study in Advanced ovArian Cancer (ISAAC Study), detailing patients' experience with abdomino-pelvic ultrasound, whole-body contrast-enhanced computed tomography (CT), and whole-body diffusion-weighted magnetic resonance imaging (WB-DWI/MRI) for pre-operative ovarian cancer work-up...
March 26, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38531053/predictive-parameters-for-spontaneous-joint-bleeding-during-emicizumab-prophylaxis
#17
JOURNAL ARTICLE
Sara Arcudi, Roberta Gualtierotti, Erica Scalambrino, Marigrazia Clerici, Shermarke Hassan, Valentina Begnozzi, Elena Anna Boccalandro, Cristina Novembrino, Carla Valsecchi, Roberta Palla, Flora Peyvandi
Emicizumab is approved for prophylaxis of patients with hemophilia A (HA). Despite its efficacy in reducing bleeding, a few patients on emicizumab still experience hemarthrosis, but no tool is yet available to identify those at higher risk of spontaneous joint bleeding. To evaluate whether laboratory measurements (global coagulation assays and emicizumab concentration) and/or arthropathy scores can distinguish patients at higher risk of spontaneous joint bleeding while on emicizumab prophylaxis. Thrombin generation assay (TGA) was assessed upon the addition of tissue factor and synthetic phospholipids...
March 26, 2024: Blood Advances
https://read.qxmd.com/read/38531001/international-prognostic-score-for-nodular-lymphocyte-predominant-hodgkin-lymphoma
#18
JOURNAL ARTICLE
Michael Sargent Binkley, Jamie E Flerlage, Kerry J Savage, Saad Akhtar, Raphael Steiner, Xiao-Yin Zhang, Michael Dickinson, Anca Prica, Ajay Major, Peter G Hendrickson, David Hopkins, Andrea Ng, Carla Casulo, Jonathan Baron, Kenneth B Roberts, Jalila Al Kendi, Alex Balogh, Umberto Ricardi, Pallawi Torka, Lena Specht, Ravindu De Silva, Keir Pickard, Lindsay J Blazin, Michael Henry, Christine M Smith, Daniel Halperin, Jessica Brady, Bernadette Brennan, Maria Anatolevna Senchenko, Marie Reeves, Bradford S Hoppe, Stephanie Terezakis, Dipti Talaulikar, Marco Picardi, Youlia Kirova, Paige Fergusson, Eliza A Hawkes, Denise Lee, Nicole Wong Doo, Allison Barraclough, Chan Y Cheah, Matthew Ku, Nada Hamad, Howard Mutsando, Michael Gilbertson, Tamara Marconi, Nicholas Viiala, Matthew J Maurer, Dennis A Eichenauer, Richard T Hoppe
PURPOSE: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and large international cooperative efforts are needed to evaluate the significance of clinical risk factors and immunoarchitectural patterns (IAPs) for all stages of pediatric and adult patients with NLPHL. METHODS: Thirty-eight institutions participated in the Global nLPHL One Working Group retrospective study of NLPHL cases from 1992 to 2021. We measured progression-free survival (PFS), overall survival (OS), transformation rate, and lymphoma-specific death rate...
March 26, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38530658/anti-ssa-ro52-and-anti-ro60-autoantibodies-association-with-clinical-phenotypes
#19
JOURNAL ARTICLE
Carolina Mazeda, Natacha Oliveira, Catarina Abreu, Vanessa Fraga, Isabel Maduro, André Saraiva, Luís Inês, Carla Ferreira, Ana Margarida Correia, Rafaela Nicolau, Filipa Farinha, Ingrid Villanueva, Diogo Jesus, Pedro Abreu, Agna Neto, Joana Silva Dinis, Anabela Barcelos
OBJECTIVES: Anti-SSA autoantibodies can be differentiated according to their antigenic target proteins as anti-Ro60 (60 kDa) or anti-Ro52 (52 kDa). Anti-SSA(Ro60) antibodies are clearly associated with connective tissue diseases (CTD), but the clinical significance of anti-SSA(Ro52) antibodies remains unclear. The aim of the present study was to analyse the disease phenotype of patients with anti-Ro52 and/or anti-Ro60 antibodies. METHODS: A multicentre, cross-sectional study was carried out of positive anti-Ro52 and/or Ro60 antibodies patients followed at 10 Rheumatology centres from January 2018 until December 2021...
March 26, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38530643/genomic-islands-of-speciation-harbor-genes-underlying-coloration-differences-in-a-pair-of-neotropical-seedeaters
#20
JOURNAL ARTICLE
Tram N Nguyen, Márcio Repenning, Carla Suertegaray Fontana, Leonardo Campagna
Incomplete speciation can be leveraged to associate phenotypes with genotypes, thus providing insights into the traits relevant to the reproductive isolation of diverging taxa. We investigate the genetic underpinnings of the phenotypic differences between Sporophila plumbea and S. beltoni. S. beltoni has only recently been described based, most notably, on differences in bill coloration (yellow vs. black in S. plumbea). Both species are indistinguishable through mtDNA or reduced-representation genomic data, and even whole-genome sequencing revealed low genetic differentiation...
March 26, 2024: Evolution; International Journal of Organic Evolution
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