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https://www.readbyqxmd.com/read/29232538/when-to-choose-transplant-in-follicular-lymphoma-navigating-a-complex-landscape
#1
Carla Casulo, Christopher R Flowers
No abstract text is available yet for this article.
December 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29232491/anhedonia-is-associated-with-suicidal-ideation-independently-of-depression-a-meta-analysis
#2
Déborah Ducasse, Gwenolé Loas, Déborah Dassa, Carla Gramaglia, Patrizia Zeppegno, Sébastien Guillaume, Emilie Olié, Philippe Courtet
BACKGROUND: Anhedonia is considered a suicide risk factor in patients with major affective disorders. Here, we wanted to quantify the association between anhedonia and current suicidal ideation according to the absence/presence of between-group differences for depressive scores and psychiatric disorders. METHODS: We performed a meta-analysis of data on studies retrieved from Medline, Web of Science, and PsycINFO from 1965 to 2016 using, among others, the terms (suicid* or depression) and anhedonia...
December 12, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29232324/vaccination-recommendations-for-adults-with-autoimmune-inflammatory-rheumatic-diseases-in-latin-america
#3
Claiton Viegas Brenol, Valderilio Feijo Azevedo, Pablo Eduardo Bonvehi, Paola Ximena Coral-Alvarado, Julio Granados, Roberto Muñoz-Louis, Carlos Pineda, Carla Vizzotti
BACKGROUND/OBJECTIVE: Patients with autoimmune inflammatory rheumatic diseases (AIRDs) are at increased risk of contracting severe infections and suffering complications, particularly when they are receiving immunomodulating therapy. Vaccination is an important means to prevent many potential infections and thereby reduce the morbidity and mortality associated with AIRD. The purpose of this consensus document is to provide health care professionals with recommendations for the vaccination of AIRD patients who reside in Latin America...
December 12, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29232213/postoperative-mortality-after-nonelective-surgery-for-inflammatory-bowel-disease-patients-in-the-era-of-biologics
#4
Carla F Justiniano, Christopher T Aquina, Adan Z Becerra, Zhaomin Xu, Courtney I Boodry, Alex A Swanger, John R T Monson, Fergal J Fleming
OBJECTIVE: The aim of the study was to analyze recent trends in the rate of nonelective surgery and corresponding mortality for inflammatory bowel disease (IBD) patients since the rise of biologic use. BACKGROUND: Modern biologic therapy has improved outcomes for IBD, but little is known about the impact on mortality rates after nonelective surgery. METHODS: New York's Statewide Planning & Research Cooperative System was queried for hospital admissions for ulcerative colitis (UC) with concurrent colectomy and Crohn disease (CD) with concurrent small bowel resection or colectomy from 2000 to 2013...
December 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29231047/cost-effectiveness-analysis-of-treatments-involving-radioembolization-in-intermediate-stage-hepatocellular-carcinoma
#5
Carla Rognoni, Oriana Ciani, Silvia Sommariva, Rosanna Tarricone
AIM: We evaluated two treatment sequences, transarterial radioembolization followed by transarterial chemoembolization and possibly sorafenib (=TTS) versus transarterial radioembolization followed by sorafenib alone (=TS), to identify the most cost-effective pathway to treat intermediate-stage hepatocellular carcinoma from the Italian healthcare system perspective. MATERIALS & METHODS: A Markov model was developed to project costs and health outcomes for TTS and TS over a lifetime horizon...
December 12, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29230816/how-grinding-levels-and-brewing-methods-espresso-american-turkish-could-affect-the-antioxidant-activity-and-bioactive-compounds-in-a-coffee-cup
#6
Antonio Derossi, Ilde Ricci, Rossella Caporizzi, Anna Fiore, Carla Severini
BACKGROUND: Depending on geographical origins and cultural traditions, different brewing procedures are used all over the world to prepare a coffee cup. In this work, we explored as three grinding levels of coffee powder and three coffee preparation methods such as by filtration (American), by boiling (Turkish) and by extraction under pressure (Espresso) affect healthy compounds and physicochemical attributes in coffee cup served to consumers. RESULTS: the grinding level slightly affects the quality of coffees, while the preparation methods significantly influenced all in-cup attributes...
December 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29230548/quality-of-life-of-patients-with-locally-advanced-head-and-neck-cancer-treated-with-induction-chemotherapy-followed-by-cisplatin-containing-chemoradiotherapy-in-the-dutch-condor-study-a-randomized-controlled-trial
#7
Chantal M L Driessen, Johannes M M Groenewoud, Jan Paul de Boer, Hans Gelderblom, Winette T A van der Graaf, Judith B Prins, Johannes H A M Kaanders, Carla M L van Herpen
PURPOSE: The CONDOR study showed that docetaxel/cisplatin/5-fluorouracil (TPF) followed by conventional radiotherapy with cisplatin 100 mg/m2 on days 1, 22, and 43 (cis100 + RT; n = 27)) versus accelerated radiotherapy with cisplatin weekly 40 mg/m2 (cis40 + ART; n = 29) in locally advanced head and neck cancer (LAHNC) patients was not feasible. Here, we report the analysis of health-related quality of life (HRQOL) of the patients entered in this study. METHODS: HRQOL was assessed at baseline, after two TPF, before start of chemoradiotherapy, and 1, 4, 8, 12, and 24 months after completion of chemoradiotherapy using the EORTC-QLQ-C30 and QLQ-H&N35 in 62 patients...
December 11, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29230024/forest-extent-and-deforestation-in-tropical-africa-since-1900
#8
Julie C Aleman, Marta A Jarzyna, A Carla Staver
Accurate estimates of historical forest extent and associated deforestation rates are crucial for quantifying tropical carbon cycles and formulating conservation policy. In Africa, data-driven estimates of historical closed-canopy forest extent and deforestation at the continental scale are lacking, and existing modelled estimates diverge substantially. Here, we synthesize available palaeo-proxies and historical maps to reconstruct forest extent in tropical Africa around 1900, when European colonization accelerated markedly, and compare these historical estimates with modern forest extent to estimate deforestation...
December 11, 2017: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29230002/deficiency-in-interferon-type-1-receptor-improves-definitive-erythropoiesis-in-klf1-null-mice
#9
Maria Francesca Manchinu, Carla Brancia, Cristian Antonio Caria, Ester Musu, Susanna Porcu, Michela Simbula, Isadora Asunis, Lucia Perseu, Maria Serafina Ristaldi
A key regulatory gene in definitive erythropoiesis is the transcription factor Krüppel-like factor 1 (Klf1). Klf1 null mice die in utero by day 15.5 (E15.5) due to impaired definitive erythropoiesis and severe anemia. Definitive erythropoiesis takes place in erythroblastic islands in mammals. Erythroblastic islands are formed by a central macrophage (Central Macrophage of Erythroblastic Island, CMEI) surrounded by maturating erythroblasts. Interferon-β (IFN-β) is activated in the fetal liver's CMEI of Klf1 null mice...
December 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29229917/whole-genome-sequencing-and-snv-genotyping-of-nebbiolo-vitis-vinifera-l-clones
#10
Giorgio Gambino, Alessandra Dal Molin, Paolo Boccacci, Andrea Minio, Walter Chitarra, Carla Giuseppina Avanzato, Paola Tononi, Irene Perrone, Stefano Raimondi, Anna Schneider, Mario Pezzotti, Franco Mannini, Ivana Gribaudo, Massimo Delledonne
'Nebbiolo' (Vitis vinifera) is among the most ancient and prestigious wine grape varieties characterised by a wide genetic variability exhibited by a high number of clones (vegetatively propagated lines of selected mother plants). However, limited information is available for this cultivar at the molecular and genomic levels. The whole-genomes of three 'Nebbiolo' clones (CVT 71, CVT 185 and CVT 423) were re-sequenced and a de novo transcriptome assembly was produced. Important remarks about the genetic peculiarities of 'Nebbiolo' and its intra-varietal variability useful for clonal identification were reported...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229732/utilization-of-variant-and-fusion-proteins-to-functionally-map-the-aggregatibacter-actinomycetemcomitans-trimeric-autotransporter-protein-apia
#11
Carla Cugini, Yongyi Mei, David Furgang, Nisha George, Narayanan Ramasubbu, Daniel H Fine
The Gram-negative bacterium Aggregatibacter actinomycetemcomitans is a causative agent of localized aggressive periodontitis. Critical to its infection process is the first and essential step of attachment, which is related to the coordinated functions of surface components comprised of proteins and extracellular polysaccharides. One such protein is the outer membrane trimeric autotransporter protein ApiA, a versatile virulence factor with numerous functions including cell binding, invasion, serum resistance, autoaggregation, and induction of cytokine release...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29229659/a-smoking-prevention-photoageing-intervention-for-secondary-schools-in-brazil-delivered-by-medical-students-protocol-for-a-randomised-trial
#12
Bianca Lisa Faria, Christian M Brieske, Ioana Cosgarea, Albert J Omlor, Fabian N Fries, Christian Olber Moreira de Faria, Henrique Augusto Lino, Ana Carla Cruz Oliveira, Oscar Campos Lisboa, Joachim Klode, Dirk Schadendorf, Breno Bernardes-Souza, Titus J Brinker
INTRODUCTION: Most smokers start smoking during their early adolescence, often with the idea that smoking is glamorous; the dramatic health consequences are too far in the future to fathom. We recently designed and tested an intervention that takes advantage of the broad availability of mobile phones as well as adolescents' interest in their appearance. A free photoageing mobile app (Smokerface) was implemented by medical students in secondary schools via a novel method called mirroring...
December 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29229379/improving-diagnosis-in-healthcare-local-versus-national-adoption-of-recommended-guidelines-for-the-clinical-breast-examination
#13
Jay N Nathwani, Anna Garren, Shlomi Laufer, Calvin Kwan, Carla M Pugh
BACKGROUND: This study explores the long-term effectiveness of a newly developed clinical skills curriculum. METHODS: Students (N = 40) were exposed to a newly developed, simulation-based, clinical breast exam (CBE) curriculum. The same students returned one year later to perform the CBE and were compared to a convenience sample of medical students (N = 15) attending a national conferences. All students were given a clinical vignette and performed the CBE. CBE techniques were video recorded...
December 5, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29229200/waste-based-alternative-adsorbents-for-the-remediation-of-pharmaceutical-contaminated-waters-has-a-step-forward-already-been-taken
#14
REVIEW
Carla Patrícia Silva, Guilaine Jaria, Marta Otero, Valdemar I Esteves, Vânia Calisto
When adsorption is considered for water treatment, commercial activated carbon is usually the chosen adsorbent for the removal of pollutants from the aqueous phase, particularly pharmaceuticals. In order to decrease costs and save natural resources, attempts have been made to use wastes as raw materials for the production of alternative carbon adsorbents. This approach intends to increase efficiency, cost-effectiveness, and also to propose an alternative and sustainable way for the valorization/management of residues...
December 2, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29228887/can-whole-body-vibration-exercises-affect-growth-hormone-concentration-a-systematic-review
#15
Laisa Liane Paineiras-Domingos, Danúbia da Cunha de Sá-Caputo, Eloá Moreira-Marconi, Danielle Soares Morel, Carla da Fontoura Dionello, Cintia Renata Sousa-Gonçalves, Éric Heleno Freire Ferreira Frederico, Pedro Jesus Marín, Sofia Tamini, Alessandro Sartorio, Mario Bernardo-Filho
Whole body vibration (WBV) has been recognized as an effective alternative exercise modality to resistance exercise for its ability in enhancing force and power, generating capacity in skeletal muscle, increasing bone mass and improving cardiovascular function. Since the effect of WBV exercises on growth hormone (GH) levels has been never compared and discussed, the aim of this study was to review systematically the literature to verify the WBV effects on GH concentration. By using PubMed, Scopus and PEDRo databases with the keywords 'growth hormone' or GH and 'whole body vibration' or WBV, we found and analysed 12 papers (182 subjects recruited), verifying their level of evidence (National Health and Medical Research Council hierarchy of evidence) and the methodological quality (PEDRo scale)...
October 2017: Growth Factors
https://www.readbyqxmd.com/read/29228658/dna-methylation-landscape-of-hepatoblastomas-reveals-arrest-at-early-stages-of-liver-differentiation-and-cancer-related-alterations
#16
Mariana Maschietto, Tatiane Cristina Rodrigues, André Yoshiaki Kashiwabara, Érica Sara Souza de Araujo, Talita Ferreira Marques Aguiar, Cecilia Maria Lima da Costa, Isabela Werneck da Cunha, Luciana Dos Reis Vasques, Monica Cypriano, Helena Brentani, Silvia Regina Caminada de Toledo, Peter Lees Pearson, Dirce Maria Carraro, Carla Rosenberg, Ana C V Krepischi
Hepatoblastomas are uncommon embryonal liver tumors accounting for approximately 80% of childhood hepatic cancer. We hypothesized that epigenetic changes, including DNA methylation, could be relevant to hepatoblastoma onset. The methylomes of eight matched hepatoblastomas and non-tumoral liver tissues were characterized, and data were validated in an independent group (11 hepatoblastomas). In comparison to differentiated livers, hepatoblastomas exhibited a widespread and non-stochastic pattern of global low-level hypomethylation...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228370/a-nf-%C3%AE%C2%BAb-signature-predicts-low-grade-glioma-prognosis-a-precision-medicine-approach-based-on-patient-derived-stem-cells
#17
Tamara Ius, Yari Ciani, Maria Elisabetta Ruaro, Miriam Isola, Marisa Sorrentino, Michela Bulfoni, Veronica Candotti, Cecilia Correcig, Evgenia Bourkoula, Ivana Manini, Enrico Pegolo, Damiano Mangoni, Stefania Marzinotto, Slobodanka Radovic, Barbara Toffoletto, Federica Caponnetto, Andrea Zanello, Laura Mariuzzi, Carla Di Loreto, Antonio Paolo Beltrami, Silvano Piazza, Miran Skrap, Daniela Cesselli
Background: While recent genome wide association studies have suggested novel low-grade glioma (LGG) stratification models based on a molecular classification, we explored the potential clinical utility of patient-derived cells. Specifically, we assayed glioma-associated stem cells (GASC) that are patient-derived stem cells representative of the glioma microenvironment. Methods: By next generation sequencing, we analyzed the transcriptional profile of GASC derived from patients that underwent anaplastic transformation either within 48 months (GASC-BAD) or ≥7 years (GASC-GOOD) after surgery...
December 7, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29227988/fire-frequency-drives-decadal-changes-in-soil-carbon-and-nitrogen-and-ecosystem-productivity
#18
Adam F A Pellegrini, Anders Ahlström, Sarah E Hobbie, Peter B Reich, Lars P Nieradzik, A Carla Staver, Bryant C Scharenbroch, Ari Jumpponen, William R L Anderegg, James T Randerson, Robert B Jackson
Fire frequency is changing globally and is projected to affect the global carbon cycle and climate. However, uncertainty about how ecosystems respond to decadal changes in fire frequency makes it difficult to predict the effects of altered fire regimes on the carbon cycle; for instance, we do not fully understand the long-term effects of fire on soil carbon and nutrient storage, or whether fire-driven nutrient losses limit plant productivity. Here we analyse data from 48 sites in savanna grasslands, broadleaf forests and needleleaf forests spanning up to 65 years, during which time the frequency of fires was altered at each site...
December 11, 2017: Nature
https://www.readbyqxmd.com/read/29227834/personality-pathology-grows-up-adolescence-as-a-sensitive-period
#19
REVIEW
Carla Sharp, Kiana Wall
There is mounting evidence that personality pathology, in particular, borderline pathology is a valid and reliable construct in adolescence, with prevalence, phenomenology, stability and risk factors similar to that of adult borderline personality disorder. Scientific evidence also delineates a marked separation of course and outcome of adolescent borderline personality disorder from other disorders and supports the efficacy of disorder-specific treatment. The current article addresses recent findings in these areas which point to adolescence as a sensitive period for the development for personality pathology...
December 6, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/29227718/training-chiropractic-students-in-weight-management-counseling-using-standardized-patients
#20
Cheryl Hawk, Michael Ramcharan, Carla LeRiche Kruger
OBJECTIVE: The aim of this study was to describe and assess an activity that trained chiropractic students to counsel patients on weight management through the use of standardized patients. METHODS: This was a descriptive study using mixed methods. Students were trained to apply health behavior theory and the transtheoretical model. Standardized patients were given a case to portray with the students. Students had 15 minutes for the encounter. The encounters were assessed in 2 ways: (1) standardized patients answered a brief questionnaire about the students' performance, and (2) students answered a questionnaire about the utility of the intervention...
December 11, 2017: Journal of Chiropractic Education
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