Rosuvastatina

BACKGROUND: Cardiovascular diseases pose a significant challenge to the society and healthcare systems, with serious implications in terms of mortality and healthcare expenditure. The treatment of cardiovascular diseases, based on acetylsalicylic acid combined with statins in multi-pill regimens, is characterized by a lower adherence rate among patients compared to the single-pill combination. A potential solution lies in single-pill formulations, drugs that combine two or more active ingredients at a fixed dosage within the same dosage unit...

INTRODUCTION: European guidelines acknowledge that patients with an acute coronary syndrome (ACS) should have LDLc levels below 70mg/dL or reduced a 50% respect to their basal levels. However, some studies demonstrated that this goal is achieved in a small number of patients. The aim of this study was to determine how cardiologists (MC) and primary care specialist (GPs) from Spain manage LDLc in ACS patients during their daily practice. METHODS: An observational, cross-sectional, multicentric study was conducted...

PURPOSE: The endothelial function is the cornerstone of several cardiovascular disease. In this trial we compared how the Nitric Oxide (NO) and Oxidative Stress (OS) serum levels, as surrogate markers of endothelial function, change in patients who received (or not) rosuvastatin during the first seven days of an acute coronary syndrome (ACS). METHODS: Twenty-two patients with ACS (age:66 +/- 9 years, gender: ten female and 12 male) were randomized in two groups...