Xinyan Wang, Kuo Yang, Ting Jia, Fanghui Gu, Chongyu Wang, Kuan Xu, Zixin Shu, Jianan Xia, Qiang Zhu, Xuezhong Zhou
The accurate identification of disease-associated genes is crucial for understanding the molecular mechanisms underlying various diseases. Most current methods focus on constructing biological networks and utilizing machine learning, particularly deep learning, to identify disease genes. However, these methods overlook complex relations among entities in biological knowledge graphs. Such information has been successfully applied in other areas of life science research, demonstrating their effectiveness. Knowledge graph embedding methods can learn the semantic information of different relations within the knowledge graphs...
March 27, 2024: Briefings in Bioinformatics