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Progesterone receptor breast cancer

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https://www.readbyqxmd.com/read/29145250/consort-independent-prognostic-value-of-asphericity-of-pretherapeutic-f-18-fdg-uptake-by-primary-tumors-in-patients-with-breast-cancer
#1
Ji-Hoon Jung, Seung Hyun Son, Do-Hoon Kim, Jeeyeon Lee, Shin Young Jeong, Sang-Woo Lee, Ho Yong Park, Jaetae Lee, Byeong-Cheol Ahn
BACKGROUND: The aim of this study was to evaluate the prognostic implication of asphericity (ASP); spatial irregularity; of pretherapeutic F 2-deoxy-2-fluoro-D-glucose (F FDG) tumor uptake in patients with invasive ductal carcinoma (IDC) of the breast. METHODS: One hundred thirty-one female IDC patients (mean age = 48.1 ± 10.4 years), with pathological tumor size greater than 2 cm were retrospectively evaluated using F FDG positron emission tomography/computed tomography (PET/CT)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144542/autoimmune-diseases-and-breast-cancer-risk-by-tumor-hormone-receptor-status-among-elderly-women
#2
Catherine Schairer, Ruth M Pfeiffer, Shahinaz M Gadalla
The female preponderance of many autoimmune diseases suggests a possible hormonal etiology. Little research exists on systemic and organ-specific autoimmune diseases and risk of breast cancer by tumor estrogen receptor (ER)- and progesterone receptor (PR)- status. Here we evaluate associations between selected systemic and organ-specific autoimmune diseases and breast cancer risk overall and by tumor ER- and PR-status. We used linked Surveillance, Epidemiology and End Results (SEER)-Medicare data, with first female breast cancer cases ages ≥66 years identified by SEER registries (years 1992-2011) (N = 209,929)...
November 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29142588/characterization-of-hormonal-receptors-and-human-epidermal-growth-factor-receptor-2-in-tissues-of-women-with-breast-cancer-at-muhimbili-national-hospital-dar-es-salaam-tanzania
#3
Amos Rodger Mwakigonja, Nyanda Elias Lushina, Ally Mwanga
Background: Breast cancer is a leading cause of morbidity and deaths among women worldwide. In Tanzania there is no published data on human epidermal growth receptor-2 (HER2/neu) expression in breast carcinoma. Hormonal receptors and HER2/neu status reportedly influence post-mastectomy adjuvant therapy and predict treatment outcome and prognosis. Here we evaluate hormonal receptors and HER-2 status in biopsies of women with breast cancer at Muhimbili National Hospital (MNH). Methods: A cross-sectional study of female breast post-modified radical mastectomy (MRM)/incisional biopsies confirmed to be carcinoma at the Histopathology Unit (January-December 2013)...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29141852/collagen-alignment-as-a-predictor-of-recurrence-after-ductal-carcinoma-in-situ
#4
Matthew W Conklin, Ronald E Gangnon, Brian L Sprague, Lisa van Germert, John M Hampton, Kevin W Eliceiri, Jeremy S Bredfeldt, Yuming Liu, Nuntida Surachaicharn, Polly A Newcomb, Andreas Friedl, Patricia Keely, Amy Trentham-Dietz
BACKGROUND: Collagen fibers surrounding breast ducts may influence breast cancer progression. Syndecan-1 interacts with constituents in the extracellular matrix, including collagen fibers, and may contribute to cancer cell migration. Thus, the orientation of collagen fibers surrounding ductal carcinoma in situ (DCIS) lesions and stromal syndecan-1 expression may predict recurrence. METHODS: We evaluated collagen fiber alignment and syndecan-1 expression in 227 women diagnosed with DCIS in 1995-2006 followed through 2014 (median 14...
November 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29138528/the-predictive-value-of-pitx2-dna-methylation-for-high-risk-breast-cancer-therapy-current-guidelines-medical-needs-and-challenges
#5
REVIEW
Michaela Aubele, Manfred Schmitt, Rudolf Napieralski, Stefan Paepke, Johannes Ettl, Magdalena Absmaier, Viktor Magdolen, John Martens, John A Foekens, Olaf G Wilhelm, Marion Kiechle
High-risk breast cancer comprises distinct tumor entities such as triple-negative breast cancer (TNBC) which is characterized by lack of estrogen (ER) and progesterone (PR) and the HER2 receptor and breast malignancies which have spread to more than three lymph nodes. For such patients, current (inter)national guidelines recommend anthracycline-based chemotherapy as the standard of care, but not all patients do equally benefit from such a chemotherapy. To further improve therapy decision-making, predictive biomarkers are of high, so far unmet, medical need...
2017: Disease Markers
https://www.readbyqxmd.com/read/29137369/lrh-1-expression-patterns-in-breast-cancer-tissues-are-associated-with-tumour-aggressiveness
#6
Jia-Min B Pang, Ramyar Molania, Ashwini Chand, Kevin Knower, Elena A Takano, David J Byrne, Thomas Mikeska, Ewan K A Millar, Cheok Soon Lee, Sandra A O'Toole, Colin Clyne, Kylie L Gorringe, Alexander Dobrovic, Stephen B Fox
The significance and regulation of liver receptor homologue 1 (LRH-1, NR5A2), a tumour-promoting transcription factor in breast cancer cell lines, is unknown in clinical breast cancers. This study aims to determine LRH-1/NR5A2 expression in breast cancers and relationship with DNA methylation and tumour characteristics. In The Cancer Genome Atlas breast cancer cohort NR5A2 expression was positively associated with intragenic CpG island methylation (1.4-fold expression for fully methylated versus not fully methylated, p=0...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137038/quantification-of-stat3-and-vegf-expression-for-molecular-diagnosis-of-lymph-node-metastasis-in-breast-cancer
#7
Yujuan Chen, Ya Liu, Yu Wang, Wen Li, Xiaolu Wang, Xuejuan Liu, Yao Chen, Chibin Ouyang, Jing Wang
BACKGROUND: Axillary lymph node metastasis is associated with increased risk of regional recurrence, distant metastasis, and poor survival in breast malignant neoplasm. Expression of signal transducer and activator of transcription 3 (STAT3) is significantly associated with tumor formation, migration, and invasion in various cancers. In addition, vascular endothelial growth factor (VEGF) expression could promote angiogenesis and increase the risk of tumorigenesis. To determine correlations among STAT3 expression, VEGF, and clinicopathological data on lymph node involvement in breast cancer patients after surgery...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137021/effect-of-antitumor-treatments-on-triple-negative-breast-cancer-patients-a-prisma-compliant-network-meta-analysis-of-randomized-controlled-trials
#8
Qiuhong Tian, Peng Du, Sen Li, Zhenzhu Bai, Yong Yang, Jinsheng Zeng
BACKGROUND: Triple-negative breast cancer (TNBC) lacks the expression of the estrogen receptor, progesterone receptor, and receptor tyrosine-protein kinase erbB-2 (HER2/neu), which renders hormone-related endocrine and targeted therapy essentially futile. OBJECTIVE: We performed a meta-analysis to assess the effects of antitumor regimens in the treatment of TNBC patients. METHODS: We searched electronic databases, including PubMed, Embase, and the Cochrane Library, through January 2017 using the following keywords: "triple negative breast cancer," "TNBC," and "random*" without language restrictions...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136733/-exploratory-study-of-circulating-tumor-dna-detection-in-early-breast-cancer-an-analysis-of-75-next-generation-sequencing-results
#9
B Zhou, L Xin, L Xu, Y H Liu, M M Zhang, R L Jing, X Y Liang, S B Cao
Objective: To explore the utility of circulating tumor DNA detection in early breast cancer by using next-generation sequencing. Methods: This exploratory study of circulating tumor DNA detection is for early invasive breast cancer patients treated in Breast Disease Center, Peking University First Hospital from December 2015 to July 2016. Plasma samples were collected and were used to isolate plasma cell-free DNA.Exons or hotspots of 247 cancer related genes were sequenced by next-generation sequencing. Mutations and their correlation with clinic-pathological factors were analyzed...
November 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29135722/assessment-of-biological-and-clinical-aggressiveness-of-invasive-ductal-breast-cancer-using-baseline-18f-fdg-pet-ct-derived-volumetric-parameters
#10
Gul Ege Aktas, Ebru Taştekin, Ali Sarikaya
OBJECTIVE: The aim of this study was to evaluate the relationship of baseline fluorine-18-fluorodeoxyglucose PET/computed tomography (CT)-derived volumetric parameters for the primary tumor with clinicopathological risk factors and molecular subtypes in patients with invasive ductal breast carcinoma (IDBC). PATIENTS AND METHODS: We evaluated 65 patients who underwent fluorine-18-fluorodeoxyglucose PET/CT for initial breast cancer staging. The association of maximum and mean standardized uptake values (SUVmax and SUVmean, respectively), metabolic tumor volume, and total lesion glycolysis (TLG) with clinicopathological risk factors and molecular subtypes was investigated and the discriminative power of significant features was assessed...
November 10, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29135104/clinicopathological-and-prognostic-significance-of-cyclin-d1-amplification-in-patients-with-breast-cancer-a-meta-analysis
#11
Qi He, Jingxun Wu, Xin-Li Liu, Yi-Han Ma, Xiao-Ting Wu, Wen-Yi Wang, Han-Xiang An
PURPOSE: Cyclin D1 plays a critical role in tumorigenesis and the regulation of the G1/S transition in the cell cycle. The relationship between cyclin D1 amplification and clinicopathological parameters in patients with breast cancer remains controversial and its impact on survival outcome is not completely clear. We conducted a meta-analysis to investigate the associations between cyclin D1 gene amplification and certain clinicopathological characteristics and the prognosis in breast cancer...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29135103/impact-of-oncotype-dx-on-chemotherapy-assignment-a-retrospective-single-center-study-on-female-breast-cancer-patients
#12
Dimitris Panousis, Panagiota Ntasiou, Dimitris Grosomanidis, Konstantinos Chatzopoulos, Georgia Paraskevakou, Panagiota Kontogianni, Efstratia Charitidou, Grigoris Xepapadakis
PURPOSE: This study was designed to determine the Recurrence Score (RS) distribution and its associated risk assessments based on traditional clinicopathologic characteristics in a single-center breast cancer (BC) deriving cohort in Greece, and to evaluate the impact of the RS results on adjuvant treatment decisions applied in this cohort. METHODS: This was a retrospective, single-center study regarding Greek female patients with early-stage breast cancer (ESBC)...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29134565/prognostic-value-of-fdg-pet-and-dwi-in-breast-cancer
#13
Kazuhiro Kitajima, Yasuo Miyoshi, Toshiko Yamano, Soichi Odawara, Tomoko Higuchi, Koichiro Yamakado
OBJECTIVE: To investigate the prognostic value of preoperative FDG-PET/CT and diffusion weighted imaging (DWI) in patients with breast cancer. METHODS: A total of 73 patients with newly diagnosed invasive breast cancer who had undergone preoperative whole-body FDG-PET/CT and 3-Tesla breast MRI including DWI followed by surgery were identified. Effects of primary tumor PET parameters [maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG)] and DWI parameters [mean apparent diffusion coefficient (ADCmean) and minimum ADC (ADCmin)] including clinicopathologic factors on disease-free survival (DFS) were retrospectively evaluated using the log-rank and Cox methods...
November 13, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29134467/diterpenoid-natural-compound-c4-crassin-exerts-cytostatic-effects-on-triple-negative-breast-cancer-cells-via-a-pathway-involving-reactive-oxygen-species
#14
Cathy E Richards, Sri H Vellanki, Yvonne E Smith, Ann M Hopkins
PURPOSE: Triple-negative breast cancers (TNBC) lack expression of three common cell surface receptors, i.e., estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). Accordingly, TNBCs are associated with fewer treatment options and a relatively poor prognosis. Having screened a National Cancer Institute natural compound library, the purpose of this study was to investigate the bioactivity of compound C4 (Crassin) in TNBC cells. METHODS: Cell viability assays were performed in two TNBC cell lines, MDA-MB-231 and 4T1, following C4 treatment in the presence or absence of the antioxidant N-acetyl-L-cysteine (NAC)...
November 13, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29132565/anatomy-and-breast-cancer-staging-is-it-still-relevant
#15
REVIEW
Jennifer K Plichta, Brittany M Campbell, Elizabeth A Mittendorf, E Shelley Hwang
Breast cancer staging concisely summarizes disease status, creating a framework for assessing and relaying prognostic information. The fundamental concepts and components of breast cancer staging are reviewed. The AJCC Cancer Staging Manual, which includes traditional anatomic factors, now includes additional tumor characteristics: tumor grade, estrogen receptor status, progesterone receptor status, human epidermal growth factor receptor 2 status, and (when available) multigene panel testing from the primary tumor...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29129161/navigation-through-inter-and-intratumoral-heterogeneity-of-endocrine-resistance-mechanisms-in-breast-cancer-a-potential-role-for-liquid-biopsies
#16
Florian Reinhardt, André Franken, Tanja Fehm, Hans Neubauer
The majority of breast cancers are hormone receptor positive due to the expression of the estrogen and/or progesterone receptors. Endocrine therapy is a major treatment option for all disease stages of hormone receptor-positive breast cancer and improves overall survival. However, endocrine therapy is limited by de novo and acquired resistance. Several factors have been proposed for endocrine therapy failures, which include molecular alterations in the estrogen receptor pathway, altered expression of cell-cycle regulators, autophagy, and epithelial-to-mesenchymal transition as a consequence of tumor progression and selection pressure...
November 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29128898/21-gene-recurrence-score-for-prognosis-and-prediction-of-taxane-benefit-after-adjuvant-chemotherapy-plus-endocrine-therapy-results-from-nsabp-b-28-nrg-oncology
#17
Eleftherios P Mamounas, Gong Tang, Soonmyung Paik, Frederick L Baehner, Qing Liu, Jong-Hyeon Jeong, S Rim Kim, Steven M Butler, Farid Jamshidian, Diana B Cherbavaz, Amy P Sing, Steven Shak, Thomas B Julian, Barry C Lembersky, D Lawrence Wickerham, Joseph P Costantino, Norman Wolmark
BACKGROUND: The 21-gene recurrence score (RS) predicts outcome and benefit from adjuvant chemotherapy benefit in breast cancer patients treated with adjuvant endocrine therapy. In the NSABP B-28 study, we evaluated the 21-gene RS for its prognostic impact and its ability to predict benefit from paclitaxel (P) in node-positive, estrogen receptor-positive (ER+) breast cancer patients treated with adjuvant chemotherapy plus tamoxifen. METHODS: The B-28 trial compared doxorubicin/cyclophosphamide (AC) with AC followed by P in 3060 patients...
November 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29126102/mirna-513a-5p-inhibits-progesterone-receptor-expression-and-constitutes-a-risk-factor-for-breast-cancer-the-ordet-prospective-study
#18
P Muti, S Donzelli, A Sacconi, A Hossain, F Ganci, T Frixa, S Sieri, V Krogh, F Berrino, F Biagioni, S Strano, J Beyene, Y Yarden, G Blandino
MicroRNAs (miRNAs) might be considered both predictors and players of cancer development. The aim of the present report was to investigate whether many years before the diagnosis of breast cancer miRNA expression is already disregulated. In order to test this hypothesis we compared miRNAs extracted from leukocytes in healthy women who later developed breast cancer and in women who remain healthy during the whole fifteen-year follow-up time. Accordantly, we used a case-control study design nested in the ORDET prospective cohort study addressing the possibility that miRNAs can serve as both early biomarkers and components of the hormonal etiological pathways leading to breast cancer development in premenopausal women...
November 4, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29119620/identification-of-oestrogen-progesterone-receptor-and-human-epidermal-growth-factor-receptor-2-expression-in-mediastinal-metastases-of-breast-cancer-obtained-by-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#19
P Serra, J Sanz-Santos, E Castellà, B Cirauqui, F Andreo, M Llatjós, M Avila, M Margelí, L Serrano, C Centeno, V Quiroga, M Torky, J Ruiz-Manzano
BACKGROUND: In breast cancer patients, the expression statuses of oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are crucial in the choice of treatment. Receptor expression in metastatic lesions can differ from the primary tumour. The aim of our study was to analyse the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to obtain samples allowing the identification of ER, PR and HER2 expression in patients with mediastinal metastases of breast cancer...
November 9, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29117498/20-year-risks-of-breast-cancer-recurrence-after-stopping-endocrine-therapy-at-5-years
#20
Hongchao Pan, Richard Gray, Jeremy Braybrooke, Christina Davies, Carolyn Taylor, Paul McGale, Richard Peto, Kathleen I Pritchard, Jonas Bergh, Mitch Dowsett, Daniel F Hayes
BACKGROUND: The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment. METHODS: In this meta-analysis of the results of 88 trials involving 62,923 women with ER-positive breast cancer who were disease-free after 5 years of scheduled endocrine therapy, we used Kaplan-Meier and Cox regression analyses, stratified according to trial and treatment, to assess the associations of tumor diameter and nodal status (TN), tumor grade, and other factors with patients' outcomes during the period from 5 to 20 years...
November 9, 2017: New England Journal of Medicine
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