Mohammad Abdallah, Lihuan Lin, Ian K Styles, Alexander Mörsdorf, James L Grace, Gracia Gracia, Cornelia B Landersdorfer, Cameron J Nowell, John F Quinn, Michael R Whittaker, Natalie L Trevaskis
Delivery to peripheral lymphatics can be achieved following interstitial administration of nano-sized delivery systems (nanoparticles, liposomes, dendrimers etc) or molecules that hitchhike on endogenous nano-sized carriers (such as albumin). The published work concerning the hitchhiking approach has mostly focussed on the lymphatic uptake of vaccines conjugated directly to albumin binding moieties (ABMs such as lipids, Evans blue dye derivatives or peptides) and their subsequent trafficking into draining lymph nodes...
March 19, 2024: Journal of Controlled Release