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https://www.readbyqxmd.com/read/28093376/a-new-angle-and-its-relationship-with-early-fixation-failure-of-femoral-neck-fractures-treated-with-three-cannulated-compression-screws
#1
Yuelei Zhang, Wei Zhang, Changqing Zhang
BACKGROUND: The Pauwels angle has been used widely, however an accurate evaluation of this angle is difficult because of deformity of the affected lower extremity. Therefore we designed a new measurement of the orientation of femoral neck fracture and applied this in a retrospective study to assess: 1) its reproducibility, 2) its advantages compared with the Pauwels angle, 3) its relationship with the short-term prognosis treated with three cannulated compression screws. HYPOTHESIS: This new measurement is reproducible and has some reference meaning for the treatment of femoral neck fractures...
January 13, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28072500/ultrasound-guided-intracardiac-xenotransfusion-of-canine-packed-red-blood-cells-and-epinephrine-to-the-left-ventricle-of-a-severely-anemic-cat-during-cardiopulmonary-resuscitation
#2
Liron Oron, Yaron Bruchim, Sigal Klainbart, Efrat Kelmer
OBJECTIVE: To describe the use of an ultrasound-guided intracardiac xenotransfusion of canine packed red blood cells (pRBC) to the left ventricle of a severely anemic cat during cardiopulmonary resuscitation (CPR). CASE SUMMARY: An 8-year-old previously healthy neutered female cat was presented with severe weakness after she had disappeared for 1 month. On presentation, the cat was in hypovolemic shock, laterally recumbent, and severely anemic with massive flea infestation...
January 10, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28065787/intestinal-farnesoid-x-receptor-controls-transintestinal-cholesterol-excretion-in-mice
#3
Jan Freark de Boer, Marleen Schonewille, Marije Boesjes, Henk Wolters, Vincent W Bloks, Trijnie Bos, Theo H van Dijk, Angelika Jurdzinski, Renze Boverhof, Justina C Wolters, Jan A Kuivenhoven, Jan M van Deursen, Ronald P J Oude Elferink, Antonio Moschetta, Claus Kremoser, Henkjan J Verkade, Folkert Kuipers, Albert K Groen
BACKGROUND & AIMS: The role of the intestine in the maintenance of cholesterol homeostasis is increasingly recognized. Fecal excretion of cholesterol is the last step in the atheroprotective reverse cholesterol transport pathway, to which biliary and transintestinal cholesterol excretion (TICE) contribute. The mechanisms controlling the flux of cholesterol through the TICE pathway are, however, poorly understood. We aimed to identify mechanisms that regulate and stimulate TICE. METHODS: We performed studies with C57Bl/6J mice, as well as mice with intestine-specific knockout of the farnesoid X receptor (FXR), mice that express an FXR transgene specifically in the intestine, and ABCG8-knockout mice...
January 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28060234/reorientational-proximal-femoral-osteotomies-for-arthrogrypotic-hip-contractures
#4
Harold Jacob Pieter van Bosse, Roger E Saldana
BACKGROUND: Severe hip contractures in arthrogrypsosis are multiplanar, which can preclude or can greatly complicate sitting and ambulation. The reorientational osteotomy at the intertrochanteric level preserves preoperative hip motion but moves it to a more functional domain. We retrospectively compared preoperative and postoperative hip motion and evaluated the ambulatory abilities of patients who underwent the procedure. METHODS: Since 2008, 65 patients with arthrogryposis had 119 reorientational proximal femoral osteotomies with a minimum follow-up of 2 years...
January 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28057168/evaluation-and-optimization-of-blood-micro-sampling-methods-serial-sampling-in-a-cross-over-design-from-an-individual-mouse
#5
Nita J Patel, Enaksha Wickremsinhe, Yu-Hua Hui, Alexandar Barr, Nicholas Masterson, Kenneth Ruterbories, Jennifer Weller, Jennifer Hanes, Tom Kern, Everett Perkins
PURPOSE: Current practices applied to mouse pharmacokinetic (PK) studies often use large numbers of animals with sporadic or composite sampling that inadequately describe PK profiles.  The purpose of this work was to evaluate and optimize blood microsampling techniques coupled with dried blood spot (DBS) and LC-MS/MS analysis to generate reliable PK data in mice.  In addition, the feasibility of cross-over designs was assessed and recommendations are presented. METHODS: The work describes a comprehensive evaluation of five blood microsampling techniques (tail clip, tail vein with needle hub, submandibular, retro-orbital, and saphenous bleeding) in CD-1 mice...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28052289/the-pharmacokinetic-interaction-study-between-carvedilol-and-bupropion-in-rats
#6
Maria Bianca Abrudan, Dana Maria Muntean, Ana Maria Gheldiu, Maria Adriana Neag, Laurian Vlase
BACKGROUND/AIMS: The effects of multiple-dose bupropion on the pharmacokinetics of single-dose carvedilol were investigated in order to evaluate this possible drug-drug interaction. METHODS: A preclinical study was conducted among white male Wistar rats. Each rat was cannulated on the femoral vein prior to being connected to BASi Culex ABC®. During the reference period, each rat received an intravenous and an oral dose of 3.57 mg/kg body weight (b.w.) carvedilol, at 2 days distance...
January 5, 2017: Pharmacology
https://www.readbyqxmd.com/read/28041770/individualised-expert-feedback-is-not-essential-for-improving-basic-clinical-skills-performance-in-novice-learners-a-randomized-trial
#7
Alexander W Phillips, Joanna Matthan, Lucy R Bookless, Ian J Whitehead, Anantha Madhavan, Paul Rodham, Anna L R Porter, Craig I Nesbitt, Gerard Stansby
OBJECTIVE: To determine whether unsupervised video feedback (UVF) is as effective as direct expert feedback (DEF) in improving clinical skills performance for medical students learning basic surgical skills-intravenous cannulation, catheterization, and suturing. BACKGROUND: Feedback is a vital component of the learning process, yet great variation persists in its quality, quantity, and methods of delivery. The use of video technology to assist in the provision of feedback has been adopted increasingly...
December 29, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/28034694/single-jugular-vein-cannulated-rats-may-not-be-suitable-for-intravenous-pharmacokinetic-screening-of-high-logp-compounds
#8
Nilesh Gaud, Anoop Kumar, Muralikrishna Matta, Prashant Kole, Srikanth Sridhar, Sandhya Mandlekar, Vinay K Holenarsipur
Rat is commonly used for pharmacokinetic screening during pharmaceutical lead optimization. To handle the large number of compounds, rats with a single jugular vein cannulation are commonly utilized for intravenous pharmacokinetic studies, where the same cannula is used both for dose administration and blood sampling. We demonstrate that the single cannula method is not suitable for all compounds, especially for high logP compounds. We propose an alternative dual cannulation technique in which two cannulas are placed in the same jugular vein, thus avoiding an additional surgery...
December 26, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28032329/pain-prevalence-in-hospitalized-children-a-prospective-cross-sectional-survey-in-four-danish-university-hospitals
#9
S Walther-Larsen, M T Pedersen, S M Friis, G B Aagaard, J Rømsing, E M Jeppesen, S J Friedrichsdorf
BACKGROUND: Pain management in hospitalized children is often inadequate. The prevalence and main sources of pain in Danish university hospitals is unknown. METHODS: This prospective mixed-method cross-sectional survey took place at four university hospitals in Denmark. We enrolled 570 pediatric patients who we asked to report their pain experience and its management during the previous 24 hours. For patients identified as having moderate to severe pain, patient characteristics and analgesia regimes were reviewed...
December 29, 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27999461/radial-artery-pseudoaneurysm-with-aberrant-radial-artery-anatomy-an-unusual-presentation-of-flexor-tenosynovitis
#10
Nicholas A Calotta, Megan E Gornet, Edward F McCarthy, Donna Magid, E Gene Deune
Purpose Radial artery pseudoaneurysm is uncommon and mainly associated with radial artery cannulization for cardiac intervention or invasive hemodynamic monitoring. It is rarely seen as a result of intra-arterial recreational drug injection. Methods We present the case of a 35-year-old man with a 12-year history of intravenous drug use and 1-year history of intra-arterial drug use who developed radial artery pseudoaneurysm with a right long finger suppurative flexor tenosynovitis and subsequent acute radial-sided hand ischemia...
December 2016: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/27995028/cost-effectiveness-analysis-of-ultrasound-guided-seldinger-peripherally-inserted-central-catheters-picc
#11
Jianghong Tan, Liping Liu, Jing Xie, Lingli Hu, Qiaolan Yang, Honghong Wang
BACKGROUND: Ultrasound-guided cannulation of deep mid-arm veins by a modified Seldinger (US-Seldinger) technique has been demonstrated to yield better puncture success rates and lower postoperative complication rates than direct cannulation of superficial veins near the elbow with a short peripheral cannula and peripherally inserted central catheter (PICC) insertion through the cannula (non-US conventional method). Economic factors have been evaluated across different operators (i.e. nurses, radiologists, and general practitioners) and different venous catheter types (i...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27990430/metformin-prevents-nonunion-after-three-cannulated-screw-fixation-in-displaced-femoral-neck-fractures-a-retrospective-study
#12
Xiao-Zhong Zhu, Xian-You Zheng
Patients aged from 40 to 60 with displaced fractures of the femoral neck (Garden III or IV) who received fixation with three cannulated screws from January 2005 to December 2012 were evaluated retrospectively for the development of nonunion. Plasma HbA1C, a marker for long-term plasma glucose level, anti-T2DM medication, and other potential risk factors were recorded for the purpose of this study. There were no differences between the union and nonunion groups with respect to age, gender, Garden classification, Pauwel's angle, reduction quality, and T2DM presence...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27958441/innovative-algorithm-to-evaluate-the-capabilities-of-visual-near-infrared-and-infrared-technologies-for-the-detection-of-veins-for-intravenous-cannulation
#13
Maryam Asrar, Amin Al-Habaibeh, Mohammed Houda
Intravenous cannulation is the process of inserting a cannula into a vein to administrate medication, fluids, or to take blood samples. The process of identification and of locating veins plays an important role during the intravenous cannulation procedure to reduce health care costs and the suffering of patients. This paper compares the three technologies used to assess their suitability and capability for the detection of veins to support the cannulation process. Three types of cameras are used in this study; a visual, an infrared, and a near infrared...
December 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27936113/preoperative-csf-melatonin-concentrations-and-the-occurrence-of-delirium-in-older-hip-fracture-patients-a-preliminary-study
#14
Rikie M Scholtens, Sophia E J A de Rooij, Annelies E Vellekoop, Bart C Vrouenraets, Barbara C van Munster
BACKGROUND: Delirium is characterized by disturbances in circadian rhythm. Melatonin regulates our circadian rhythm. Our aim was to compare preoperative cerebrospinal fluid (CSF) melatonin levels in patients with and without postoperative delirium. METHODS: Prospective cohort study with hip fracture patients ≥ 65 years who were acutely admitted to the hospital for surgical treatment and received spinal anaesthesia. CSF was collected after cannulation, before administering anaesthetics...
2016: PloS One
https://www.readbyqxmd.com/read/27897734/how-to-insert-a-peripheral-cannula
#15
Sally Jane Shaw
Rationale and key points This article aims to assist practitioners to undertake the safe and effective insertion of a peripheral cannula. It provides information on best practice related to peripheral cannulation with an open-ported safety cannula. The same principles for practice apply to non-ported open safety cannulae. » Peripheral cannulation enables venous access, the administration of intravenous medication, infusion therapy and total parenteral nutrition. It also enables blood samples to be obtained...
November 16, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27878800/a-single-center-experience-of-the-implementation-of-adrenal-vein-sampling-procedure-impact-on-the-diagnostic-work-up-in-primary-aldosteronism
#16
Jacek Kądziela, Aleksander Prejbisz, Ilona Michałowska, Sylwia Kołodziejczyk-Kruk, Leo Schultze Kool, Marek Kabat, Hanna Janaszek-Sitkowska, Sadegh Toutounchi, Zbigniew Gałązka, Urszula Ambroziak, Tomasz Bednarczuk, Magdalena Januszewicz, Dorota Ptasińska-Wnuk, Michał Hoffmann, Andrzej Januszewicz, Adam Witkowski
BACKGROUND AND AIM: Primary aldosteronism (PA) is one of the most common causes of secondary hypertension. Adrenal vein sampling (AVS) remains a "gold standard" procedure in differentiation between unilateral (adenoma) and bilateral (hyperplasia) disease. We present our single-center experience in establishing and implementation of the AVS procedure. METHODS: All patients had primary aldosteronism confirmed in salt-infusion test. Adrenal vein sampling was performed sequentially during a continuous intravenous infusion of cosyntropin and was preceded by multislice contrast-enhanced computed tomography (CT) examination of adrenal glands performed few weeks before AVS in majority of patients...
November 23, 2016: Kardiologia Polska
https://www.readbyqxmd.com/read/27848412/intravenous-cannula-site-management
#17
Claire Dempsey
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The CPD article provided information about safe and effective practice in intravenous cannulation, including indications for cannulation, appropriate cannulation sites, types and sizes of cannula, cannula maintenance, recognising and avoiding complications.
November 9, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27790552/comparative-evaluation-of-volatile-anaesthetic-agents-for-attenuation-of-venous-cannulation-pain-a-prospective-randomized-controlled-study
#18
Vinit K Srivastava, Pravin K Das, Sujeet Ks Gautam, Parineeta Jaisawal, Venkat N Kadiyala, Sonal Rambhad
INTRODUCTION: Topical application of volatile anaesthetic agents has been found to attenuate the response to a mechanical stimulus; however, this effect of volatile anaesthetic on perception of pain during venous cannulation is not known. AIM: To compare the efficacy of topically administered volatile anaesthetic agents for attenuating venous cannulation pain. MATERIALS AND METHODS: This prospective, randomized, placebo controlled and double blind study was conducted on 120 patients, aged 20-60years...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27787571/-anesthesia-for-medical-students-a-brief-guide-to-practical-anesthesia-in-adults-with-a-web-based-video-illustration
#19
S Mathis, O Schlafer, J Abram, J Kreutziger, P Paal, V Wenzel
In Germany, Austria and Switzerland, anesthesiologists are the second largest group of physicians in hospitals, but this does not correspond to the amount of anesthesiology teaching that medical students receive in medical schools. Accordingly, the chances of medical students recognizing anesthesiology as a promising personal professional career are smaller than in other disciplines with large teaching components. Subsequent difficulties to recruit anesthesiology residents are likely, although many reasons support anesthesiology as a professional career...
December 2016: Der Anaesthesist
https://www.readbyqxmd.com/read/27785562/utility-of-near-infrared-light-devices-for-pediatric-peripheral-intravenous-cannulation-a-systematic-review-and-meta-analysis
#20
Joon Min Park, Min Joung Kim, Hyeon Woo Yim, Won-Chul Lee, Hyunsuk Jeong, Na Jin Kim
: We investigated the utility of near-infrared (NIR) light devices for peripheral intravenous cannulation (PIVC) in pediatric patients. We searched three databases, MEDLINE, EMBASE, and the Cochrane CENTRAL. Randomized controlled trials that compared PIVC using NIR light devices and the "traditional" method (with no assistive device) were included. The primary outcome was a failure rate at the first attempt, and the effect size was measured by the risk ratio for failure. Subgroup analysis was performed according to control group risk for failure at first attempt as an indicator of difficult procedure (low vs...
December 2016: European Journal of Pediatrics
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