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graphene scaffold

Hande Nalvuran, Ayşe Eser Elçin, Yaşar Murat Elçin
Graphene and silk fibroin (SF) have been extensively investigated in the literature. Hybrid scaffolds of SF and graphene combine the properties of both of the materials and provide promising applications for tissue engineering purposes. In this study, reduced graphene oxide (RGO) (0.5%, 1.0% and 2.0% (w/v)) was incorporated into SF and fabricated into composite nanofibers through electrospinning. The fibers were characterized and analyzed by SEM, XRD, FTIR, TGA, circular dichroism analysis, contact angle measurements and tensile tests...
March 15, 2018: International Journal of Biological Macromolecules
Ali Deniz Dalgic, Ammar Zeidan Alshemary, Ayşen Tezcaner, Dilek Keskin, Zafer Evis
In this study, novel graphene oxide-incorporated silicate-doped nano-hydroxyapatite composites were prepared and their potential use for bone tissue engineering was investigated by developing an electrospun poly(ε-caprolactone) scaffold. Nanocomposite groups were synthesized to have two different ratios of graphene oxide (2 and 4 wt%) to evaluate the effect of graphene oxide incorporation and groups with different silicate-doped nano-hydroxyapatite content was prepared to investigate optimum concentrations of both silicate-doped nano-hydroxyapatite and graphene oxide...
January 1, 2018: Journal of Biomaterials Applications
Lili Jiang, Zhifeng Ren, Shuo Chen, Qinyong Zhang, Xiong Lu, Hongping Zhang, Guojiang Wan
This paper reports a novel loofah-derived hierarchical scaffold to obtain three-dimensional biocarbon-graphene-TiO2 (BC-G-TiO2 ) composite materials as electrodes for supercapacitors. The loofah scaffold was first loaded with G and TiO2 by immersing, squeezing, and loosening into the mixed solution of graphene oxide and titania, and then carbonized at 900 °C to form the BC-G-TiO2 composite. The synergistic effects of the naturally hierarchical biocarbon structure, graphene, and TiO2 nanoparticles on the electrochemical properties are analyzed...
March 13, 2018: Scientific Reports
M Duran, A C M Luzo, J G de Souza, W J Favaro, P Garcia, N Duran
Graphene and graphene oxide topography have an effect on the fate of stem cells such as adhesion, differentiation, and proliferation. This overview clearly shows that a new design and manipulation of associated graphene oxide stem cell culture platforms are of paramount importance as a focus in stem cell to tissue engineering applications. This overview also proposes that a film of graphene oxide is an efficient platform to modulate structure and function of multipotent mesenchymal stem/stromal cells (MSCs) and in special human adipose tissue derived mesenchymal stromal/stem cells (AT-MSCs)...
March 7, 2018: Current Molecular Medicine
Firas Awaja, Giorgio Speranza, Heike Kaltenegger, Débora Coraça-Huber, Birgit Lohberger
Osteo-integration and tissue regeneration are vital for the longevity, durability, and unremitting functionality of medical implants/scaffolds implanted in vivo. It's essential for biomaterials used for in vivo implantation to induce the cellular secretion of growth factors, necessary for the desired tissue generation, since the administration of artificial growth factors, in vivo, is largely prohibited. Plasma functionalized (N2 and O2 ) and stabilized Graphene Oxide (GO) thin layers in a hybrid with amorphous carbon (aC) induced the expression of vascular endothelial growth factor (VEGF) and osteoprotegerin (OPG) growth factors in fibroblasts (hGF) and, more remarkably, in osteoblasts (hFOB) cells confirming the suitability for tissue regeneration and osteo-integration applications...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Lia Macedo Coelho Lima, Hadi Arjmandi-Tash, Grégory F Schneider
Developing a clean handling and transfer process, capable to preserve the integrity of the crystal is still a challenge with two-dimensional materials. Here, we present a flexible, dynamic and molecular lipid-based scaffold that clamps graphene at the edges providing a practical, simple and clean graphene manipulation and transfer method. Langmuir films with different surface pressures of lipids are deposited at the air/copper-etchant interface immediately after placing the graphene on copper samples. We show that at surface pressures above 30 mN/m, the lateral support prevents graphene movement and cracking during all the etching and transfer...
March 7, 2018: ACS Applied Materials & Interfaces
Sandra Sánchez-González, Nazely Diban, Ane Urtiaga
The present work studies the functional behavior of novel poly(ε-caprolactone) (PCL) membranes functionalized with reduced graphene oxide (rGO) nanoplatelets under simulated in vitro culture conditions (phosphate buffer solution (PBS) at 37 °C) during 1 year, in order to elucidate their applicability as scaffolds for in vitro neural regeneration. The morphological, chemical, and DSC results demonstrated that high internal porosity of the membranes facilitated water permeation and procured an accelerated hydrolytic degradation throughout the bulk pathway...
March 5, 2018: Membranes
João C Boga, Sónia P Miguel, Duarte de Melo-Diogo, António G Mendonça, Ricardo O Louro, Ilídio J Correia
The incidence of fractures and bone-related diseases like osteoporosis has been increasing due to aging of the world's population. Up to now, grafts and titanium implants have been the principal therapeutic approaches used for bone repair/regeneration. However, these types of treatment have several shortcomings, like limited availability, risk of donor-to-recipient infection and tissue morbidity. To overcome these handicaps, new 3D templates, capable of replicating the features of the native tissue, are currently being developed by researchers from the area of tissue engineering...
February 21, 2018: Colloids and Surfaces. B, Biointerfaces
Huanhuan Gong, Mengli Zhao, Dejun Li, Rongxin Wan, Hanqing Gu
In this paper, three-dimensional self-assembly graphene (3D-G) was prepared by the hydrothermal synthesis method, and 3D-G was designed as a suitable biological scaffold for cell growth and adhesion. The shape of 3D-G was tuned by adjusting the hydrothermal reaction time (6 h, 12 h, 18 h and 24 h). Then the scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) analyses were used to characterize the microstructure and component of 3D-G, which showed that the length, diameter, pore size and defects of 3D-G were all decreased as the reaction-time increased...
August 1, 2018: Journal of Nanoscience and Nanotechnology
Jiajia Song, Yanyan Wang, Feng Zhang, Yan Ye, Yanhua Liu, Xiaohong Zhou, Linsen Chen, Changsi Peng
In this work, gas sensors based on chemically reduced graphene oxide (rGO) foams were reported for NH3 detection. Polymer foams were used as scaffolds to support rGO, and the resultant soft sensing devices exhibited a high sensitivity, high selectivity, and rapid recovery for NH3 detection at room temperature. The sensor showed more than 0.90% and 3.67% resistance changes respectively, when it's exposed to 1 ppm and 50 ppm NH3. The graphene foam gas sensors (FGS) also showed excellent repeatability. Furthermore, the response of rGO foam gas sensor to NH3 was more than two times higher than that to methanol vapors diluted to 1% of the saturated vapor concentration...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Zhiying Wang, He Shen, Saijie Song, Liming Zhang, Wei Chen, Jianwu Dai, Zhijun Zhang
Delivery of functional genes into stem cells shows great application prospect in DNA-based tissue engineering. However, comparing with epithelial cells and cancer cells, stem cells usually exhibit low gene transfection efficiency. To enhance the transfection efficiency, non-viral gene delivery in combination with biomaterial scaffolds, has raised increasing interests from researchers in tissue engineering. Nanofibers fabricated by electrospinning technique mimicking extracellular matrix (ECM) are widely used in tissue engineering applications...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Guanhui Gao, Lingwei Wang, Peng Yang, Liang Huang, Xiaobin Xie, Jingsong Wu, Chen Qiu, Lintao Cai
We developed a facile and green bio-inspired strategy to fabricate silver nano-particles growth in-situ on different scaffolds materials, building novel heterostructures for promoting their antibacterial activities and durability. Firstly, fluorinated graphene oxide (FGO) nanosheets, layered molybdenum disulfide (MoS2), and layered tungsten disulfide (WS2) were exfoliated by chemical liquid with intense sonication. And silicon dioxide (SiO2) nano-spheres were prepared via wet chemical method. Then, silver nanoparticles were grown onto those surfaces of layered nanosheets and nano-spheres, hybridizing three dimensional hetero-architectures...
June 1, 2018: Journal of Nanoscience and Nanotechnology
Anh Tuan Nguyen, Sabrina Mattiassi, Manuela Loeblein, Eunice Chin, DongLiang Ma, Philippe Coquet, Virgile Viasnoff, E H T Teo, Eyleen L Goh, Evelyn Yim
Studies of electrical stimulation therapies for the treatment of neurological disorders, such as deep brain stimulation, have almost exclusively been performed using animal-models. However, because animal-models can only approximate human brain disorders, these studies should be supplemented with an in vitro human cell-culture based model to substantiate the results of animal-based studies and further investigate therapeutic benefit in humans. This study presents a novel approach to analyse the effect of electrical stimulation on the neurogenesis of patient-induced pluripotent stem cell (iPSC) derived neural progenitor cell (NPC) lines, in vitro using a 3D graphene scaffold system...
February 14, 2018: Biomedical Materials
Ponrasu Thangavel, Ramya Kannan, Balaji Ramachandran, Ganeshkumar Moorthy, Lonchin Suguna, Vignesh Muthuvijayan
Treatment of chronic non-healing wounds in diabetes is still a major clinical challenge. Here, we have developed reduced graphene oxide (rGO) loaded isabgol nanocomposite scaffolds (Isab + rGO) to treat normal and diabetic wounds. rGO was synthesized by rapid reduction of graphene oxide (GO) under focused solar radiation. Then, rGO was uniformly dispersed into isabgol solution to prepare Isab + rGO nanocomposite scaffolds. These scaffolds were characterized using various physiochemical techniques. Isab + rGO nanocomposite scaffolds showed suitable cell viability, proliferation, and attachment...
February 2, 2018: Journal of Colloid and Interface Science
Yaimara Solìs Moré, Gloria Panella, Giulia Fioravanti, Francesco Perrozzi, Maurizio Passacantando, Francesco Giansanti, Matteo Ardini, Luca Ottaviano, Annamaria Cimini, Carlos Peniche, Rodolfo Ippoliti
Novel 2D films and 3D scaffolds based on chitosan (CHI), apatite (Ap) and graphene oxide (GO) were developed by an in situ synthesis in which self-assembly process was conducted to direct partial reduction of GO by chitosan in acidic medium. Physical-chemical characterization was carried out by optical microscopy (OM), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). In vitro biological studies using murine fibroblast (MC3T3) and human neuroblastoma (SH-SY5Y) cell lines were also performed...
February 9, 2018: Journal of Biomedical Materials Research. Part A
Iwona Lasocka, Lidia Szulc-Dąbrowska, Michał Skibniewski, Ewa Skibniewska, Włodzimierz Strupinski, Iwona Pasternak, Hubert Kmieć, Paweł Kowalczyk
The aim of the present study was to evaluate the cytotoxicity of pristine graphene monolayer and its utility as a scaffold for murine fibroblast L929 cell line. Cell viability, morphology, cytoskeleton architecture (microfilaments and microtubules), cell adhesion and migration into the scratch-wound area were determined using pristine graphene-coated microscopic slides. We found that fibroblasts cultured on pristine graphene monolayer exhibited changes in cell attachment, motility and cytoskeleton organization...
January 31, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Lu Han, Honglong Sun, Pengfei Tang, Pengfei Li, Chaoming Xie, Menghao Wang, Kefeng Wang, Jie Weng, Hui Tan, Fuzeng Ren, Xiong Lu
Graphene oxide (GO) attracts considerable attention for biomedical applications owing to its unique nanostructure and remarkable physicochemical characteristics. However, it is challenging to uniformly deposit GO on chemically inert Ti scaffolds, which have good biocompatibility and wide applications in bone engineering. In this study, a GO-functionalized Ti porous scaffold (GO/Ti scaffold) was prepared by depositing GO onto polydopamine (PDA) modified Ti scaffolds. The mussel-inspired PDA modification facilitated the interaction between GO and Ti surfaces, leading to a uniform coverage of GO on Ti scaffolds...
January 29, 2018: Biomaterials Science
Yun Qian, Xiaotian Zhao, Qixin Han, Wei Chen, Hui Li, Weien Yuan
As a conductive nanomaterial, graphene has huge potentials in nerve function restoration by promoting electrical signal transduction and metabolic activities with unique topological properties. Polydopamine (PDA) and arginylglycylaspartic acid (RGD) can improve cell adhesion in tissue engineering. Here we report an integrated 3D printing and layer-by-layer casting (LBLC) method in multi-layered porous scaffold fabrication. The scaffold is composed of single-layered graphene (SG) or multi-layered graphene (MG) and polycaprolactone (PCL)...
January 22, 2018: Nature Communications
Chunyong Liang, Yongchao Luo, Guodong Yang, Dan Xia, Lei Liu, Xiaomin Zhang, Hongshui Wang
Biodegradable porous biomaterial scaffolds play a critical role in bone regeneration. In this study, the porous nano-hydroxyapatite/collagen/poly(lactic-co-glycolic acid)/graphene oxide (nHAC/PLGA/GO) composite scaffolds containing different amount of GO were fabricated by freeze-drying method. The results show that the synthesized scaffolds possess a three-dimensional porous structure. GO slightly improves the hydrophilicity of the scaffolds and reinforces their mechanical strength. Young's modulus of the 1...
January 11, 2018: Nanoscale Research Letters
Shu-Dong Wang, Qian Ma, Ke Wang, Pi-Bo Ma
Silk fibroin (SF) is blended with graphene oxide (GO) to prepare the strong and biocompatible three dimensional porous SF/GO blended scaffold via phase separation. GO could be well dispersed in SF solution and GO could also be well distributed in the SF scaffold. Furthermore, the introduction of GO can lead to structural change in the bended scaffold. Higher concentration of GO resulted in more compact structure and smaller pore size of the composite scaffolds without decreasing their porosity. Scanning electron microscopy and energy dispersive spectrometry results also reveal that SF and GO are homogeneous blended together...
January 7, 2018: International Journal of Biological Macromolecules
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