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graphene scaffold

Mengli Zhao, Ye Cao, Huanhuan Gong, Yanqiu Sun, Jianhua Deng, Dejun Li, Rongxin Wan, Hanqing Gu
One of the key challenges in engineering tissues for cell-based therapies is developing biocompatible scaffold materials to direct cell behavior. In this paper, the cytocompatibilities of a flexible three-dimensional graphene scaffold (3D-G) and the same scaffold implanted with nitrogen ions (N+ /3D-G) are compared using an in vitro assay based on 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. The N+ /3D-G samples were prepared from low-temperature hydrothermally synthesized flexible 3D-G by ion implantation and were found to display improved adhesion and proliferation of rat osteoblast and mouse fibroblast cells...
May 16, 2018: Biointerphases
Jing Chu, Panpan Shi, Wenxia Yan, Jinping Fu, Zhi Yang, Chengmin He, Xiaoyuan Deng, Hanping Liu
Nanoscale delivery based on polyethylene glycol (PEG)ylated graphene oxide (GO-PEG) merits attention for biomedical applications owing to its functional surface modification, superior solubility/biocompatibility and controllable drug release capability. However, impaired skin regeneration in applications of these fascinating nanomaterials in diabetes is still limited, and critical issues need to be addressed regarding insufficient collagen hyperplasia and inadequate blood supply. Therefore, a high-performance tissue engineering scaffold with biocompatible and biodegradable properties is essential for diabetic wound healing...
May 10, 2018: Nanoscale
Ayca Aslan, Adil Allahverdiyev, Melahat Bagirova, Emrah Abamor
BACKGROUND: Today, coronary artery disease is still one of the most important causes of mortality despite advanced surgical methods, pharmacotherapies and organ transplantation. These treatment modalities are intended to prevent further progression of myocardial infarction and do not involve the repair of the damaged part. Therefore, stem cell therapy has emerged as a new approach for the treatment of coronary artery disease. However, there are some restrictions that limit the use of these cells for desired repair...
May 9, 2018: Current Stem Cell Research & Therapy
Ming Li, Pan Xiong, Feng Yan, Sijie Li, Changhong Ren, Zhichen Yin, Ang Li, Huafang Li, Xunming Ji, Yufeng Zheng, Yan Cheng
Hydroxyapatite (HA) is an attractive bioceramic for hard tissue repair and regeneration due to its physicochemical similarities to natural apatite. However, its low fracture toughness, poor tensile strength and weak wear resistance become major obstacles for potential clinical applications. One promising method to tackle with these problems is exploiting graphene and its derivatives (graphene oxide and reduced graphene oxide) as nanoscale reinforcement fillers to fabricate graphene-based hydroxyapatite composites in the form of powders, coatings and scaffolds...
March 2018: Bioactive Materials
Zhuo Chen, Zhenghao Sun, Yongguang Zhang, Taizhe Tan, Yuan Tian, Zhihong Chen
Sulfur/ethylenediamine-functionalized reduced graphene oxide (S/EDA-RGO) nanocomposites were synthesized using a simple process. Ethylenediamine (EDA) was employed as both the reducing agent and the modification component. The morphologies, microstructures, and compositions of S/EDA-RGO composites were characterized by various detection techniques. The data indicated that EDA-RGO used as scaffolds for sulfur cathodes could enhance the electronic conductivity of the composites and strengthen the adsorbability of polysulfides...
May 6, 2018: Nanomaterials
Ana Martin Pacheco, Antonio Esau Del Rio Castillo, Cristina Martín, Maria Antonia Herrero, Sonia Merino, Jose Luis Garcia Fierro, Enrique Díez Barra, Ester Vázquez
Fluorescence based on quantum confinement is a property restricted to the nanoscopic range. The incorporation of nanoparticles in a three-dimensional polymeric network could afford macroscopic scaffolds that show nanoscopic properties. Moreover, if these scaffolds are based on strong bonds, the stability of the resulting materials can be preserved, thus enhancing their final applications. We report for the first time the preparation of a graphene quantum dot (GQD)-composite based on a cationic covalent network...
May 7, 2018: ACS Applied Materials & Interfaces
Yun Qian, Jialin Song, Xiaotian Zhao, Wei Chen, Yuanming Ouyang, Weien Yuan, Cunyi Fan
Treating peripheral nerve injury faces major challenges and may benefit from bioactive scaffolds due to the limited autograft resources. Graphene oxide (GO) has emerged as a promising nanomaterial with excellent physical and chemical properties. GO has functional groups that confer biocompatibility that is better than that of graphene. Here, GO/polycaprolactone (PCL) nanoscaffolds are fabricated using an integration molding method. The nanoscaffolds exhibit many merits, including even GO nanoparticle distribution, macroporous structure, and strong mechanical support...
April 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Kohei Kawamoto, Hirofumi Miyaji, Erika Nishida, Saori Miyata, Akihito Kato, Akito Tateyama, Tomokazu Furihata, Kanako Shitomi, Toshihiko Iwanaga, Tsutomu Sugaya
Introduction: The 3-dimensional scaffold plays a key role in volume and quality of repair tissue in periodontal tissue engineering therapy. We fabricated a novel 3D collagen scaffold containing carbon-based 2-dimensional layered material, named graphene oxide (GO). The aim of this study was to characterize and assess GO scaffold for periodontal tissue healing of class II furcation defects in dog. Materials and methods: GO scaffolds were prepared by coating the surface of a 3D collagen sponge scaffold with GO dispersion...
2018: International Journal of Nanomedicine
Qingqing Yao, Yangxi Liu, Hongli Sun
The recently developed three-dimensional (3D) graphene foam (GrF) is intriguing for potential bone tissue engineering applications since it provides stem cells with a 3D porous substrate for osteogenic differentiation. However, the nature of graphene's structure lacks functional groups thus making it difficult for further modification such as immobilization or conjugation of growth factors, which are normally required to promote tissue regeneration. To explore the potential of GrF functionalization and sustained release of therapeutic proteins, we fabricated a modified 3D GrF scaffold with bio-inspired heparin-dopamine (Hepa-Dopa) molecules using a highly scalable chemical vapor deposition (CVD) method...
April 27, 2018: Journal of Tissue Engineering and Regenerative Medicine
Jiao Yang Lu, Xin Xing Zhang, Qiu Yan Zhu, Fu Rui Zhang, Wei Tao Huang, Xue Zhi Ding, Li Qiu Xia, Hong Qun Luo, Nian Bing Li
Patterning graphene allows to precisely tune its properties to manufacture flexible functional materials or miniaturized devices for electronic and biomedical applications. However, conventional lithographic techniques are cumbersome for scalable producing time- and cost-effective graphene patterns, thus greatly impeding their practical applications. Here we present a simple scalable fabrication of wafer-scale 3D graphene micropatterns by direct laser tuning expansion and reduction of graphene oxide using a standard LightScribe DVD burner...
April 27, 2018: ACS Applied Materials & Interfaces
Jekaterina Kazantseva, Irina Hussainova, Roman Ivanov, Toomas Neuman, Michael Gasik
A challenge in regenerative medicine is governed by the need to have control over the fate of stem cells that is regulated by the physical and chemical microenvironment in vitro and in vivo . The differentiation of the stem cells into specific lineages is commonly guided by use of specific culture media. For the first time, we demonstrate that human mesenchymal stem cells are capable of turning spontaneously towards neurogenic lineage when seeded on graphene-augmented, highly anisotropic ceramic nanofibres without special differentiation media, contrary to commonly thought requirement of 'soft' substrates for the same purpose...
June 6, 2018: Interface Focus
Mattia Bramini, Giulio Alberini, Elisabetta Colombo, Martina Chiacchiaretta, Mattia L DiFrancesco, José F Maya-Vetencourt, Luca Maragliano, Fabio Benfenati, Fabrizia Cesca
The scientific community has witnessed an exponential increase in the applications of graphene and graphene-based materials in a wide range of fields, from engineering to electronics to biotechnologies and biomedical applications. For what concerns neuroscience, the interest raised by these materials is two-fold. On one side, nanosheets made of graphene or graphene derivatives (graphene oxide, or its reduced form) can be used as carriers for drug delivery. Here, an important aspect is to evaluate their toxicity, which strongly depends on flake composition, chemical functionalization and dimensions...
2018: Frontiers in Systems Neuroscience
Seung-Keun Park, Jin Sung Park, Yun Chan Kang
Developing carbon scaffolds showing rational pore structures as cathode hosts is essential for achieving superior electrochemical performances of lithium-selenium (Li-Se) batteries. Hierarchically porous N-doped carbon polyhedrons anchored on crumpled graphene balls (NPC/CGBs) are synthesized by carbonizing a zeolitic imidazolate framework-8 (ZIF-8)/CGB composite precursor, producing an unprecedented effective host matrix for high-performance Li-Se batteries. Mesoporous CGBs obtained by one-pot spray pyrolysis are used as a highly conductive matrix for uniform polyhedral ZIF-8 growth...
April 25, 2018: ACS Applied Materials & Interfaces
Shengyang Dong, Zhifei Li, Zhenyu Xing, Xianyong Wu, Xiulei Ji, Xiaogang Zhang
To fill the gap between batteries and supercapacitors requires integration of the following features in a single system: energy density well above that of supercapacitors, cycle life much longer than Li-ion batteries, and low cost. Along this line, we report a novel non-aqueous potassium-ion hybrid capacitor (KIC) that employs an anode of K2Ti6O13 (KTO) micro-scaffolds constructed by nanorods and a cathode of N-doped nanoporous graphenic carbon (NGC). K2Ti6O13 micro-scaffolds are studied for potential applications as the anode material in potassium-ion storage for the first time...
April 23, 2018: ACS Applied Materials & Interfaces
Giovanna M D'Abaco, Cristiana Mattei, Babak Nasr, Emma J Hudson, Abdullah J Alshawaf, Gursharan Chana, Ian P Everall, Bryony Nayagam, Mirella Dottori, Efstratios Skafidas
In this study, we explore the use of electrically active graphene foam as a scaffold for the culture of human-derived neurons. Human embryonic stem cell (hESC)-derived cortical neurons fated as either glutamatergic or GABAergic neuronal phenotypes were cultured on graphene foam. We show that graphene foam is biocompatible for the culture of human neurons, capable of supporting cell viability and differentiation of hESC-derived cortical neurons. Based on the findings, we propose that graphene foam represents a suitable scaffold for engineering neuronal tissue and warrants further investigation as a model for understanding neuronal maturation, function and circuit formation...
March 2018: Royal Society Open Science
Duo Wu, Archana Samanta, Rajiv K Srivastava, Minna Hakkarainen
A versatile and convenient way to produce bioactive poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) electrospun nanofibrous scaffolds is described. PLA and PCL are extensively used as biocompatible scaffold materials for tissue engineering. Here, biobased nano graphene oxide dots (nGO) are incorporated in PLA or PCL electrospun scaffolds during the electrospinning process aiming to enhance the mechanical properties and endorse osteo-bioactivity. nGO was found to tightly attach to the fibers through secondary interactions...
April 6, 2018: Materials
Nariman Yousefi, Kerwin K W Wong, Zeinab Hosseinidoust, Henning Osholm Sørensen, Stefan Bruns, Yi Zheng, Nathalie Tufenkji
Self-assembly of graphene oxide (GO) nanosheets into porous 3D sponges is a promising approach to exploit their capacity to adsorb contaminants while facilitating the recovery of the nanosheets from treated water. Yet, forming mechanically robust sponges with suitable adsorption properties presents a significant challenge. Ultra-strong and highly porous 3D sponges are formed using GO, vitamin C (VC), and cellulose nanocrystals (CNCs) - natural nanorods isolated from wood pulp. CNCs provide a robust scaffold for the partially reduced GO (rGO) nanosheets resulting in an exceptionally stiff nanohybrid...
April 5, 2018: Nanoscale
Ruling Huang, Meiling Huang, Xiaofeng Li, Fei An, Nikhil Koratkar, Zhong-Zhen Yu
The development of fully foldable energy storage devices is a major science and engineering challenge, but one that must be overcome if next-generation foldable or wearable electronic devices are to be realized. To overcome this challenge, it is necessary to develop new electrically conductive materials that exhibit superflexibility and can be folded or crumpled without plastic deformation or damage. Herein, a graphene film with engineered microvoids is prepared by reduction (under confinement) of its precursor graphene oxide film...
April 2, 2018: Advanced Materials
Yaxin Chen, Liluo Shi, Qiong Yuan, Ang Li, Shaozhuan Huang, Hui Ying Yang, Xiaohong Chen, Jisheng Zhou, Huaihe Song
Although nucleation and crystallization in solution-processed materials synthesis is a natural phenomenon, the morphology design of graphene nanosheets by controlling the dual crystallization has not been established. In this work, we systematically demonstrate how the dual crystallization of ice and potassium chloride induces the morphological variation of the freeze-dried scaffold from fractal structure towards stepped sheet-like structure. Denim-like graphene nanosheet (DGNS) has been fabricated by annealing the F127-coated stepped sheet-like scaffold in nitrogen...
April 2, 2018: ACS Nano
Elayaraja Kolanthai, Abinaya Sindu P, Deepak Kumar Khajuria, Sarath Chandra Veerla, Dhandapani Kuppuswamy, Luiz Henrique Catalani, D Roy Mahapatra
Developing a biodegradable scaffold remains a major challenge in bone tissue engineering. This study was aimed at developing novel alginate-chitosan-collagen (SA-CS-Col) based composite scaffolds consisting of graphene oxide (GO) to enrich porous structures, elicited by freeze-drying technique. To characterize porosity, water absorption and compressive modulus, GO scaffolds (SA-CS-Col-GO) were prepared with and without Ca2+ -mediated crosslinking (chemical crosslinking) and analyzed using Raman, FTIR, XRD, and SEM techniques...
March 28, 2018: ACS Applied Materials & Interfaces
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