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https://www.readbyqxmd.com/read/29344460/impact-of-integrated-teaching-sessions-for-comprehensive-learning-and-rational-pharmacotherapeutics-for-medical-undergraduates
#1
Sneha Ambwani, Bhavisha Vegada, Rimple Sidhu, Jaykaran Charan
Background: It is postulated that integrated teaching method may enhance retention of the knowledge and clinical applicability of the basic sciences as compared to the didactic method. Aim: The present study was undertaken to compare the integrated teaching method with the didactic method for the learning ability and clinical applicability of the basic sciences. Materials and Methods: The 2nd year MBBS students were divided into two groups randomly...
December 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29340287/fully-automated-detection-of-breast-cancer-in-screening-mri-using-convolutional-neural-networks
#2
Mehmet Ufuk Dalmış, Suzan Vreemann, Thijs Kooi, Ritse M Mann, Nico Karssemeijer, Albert Gubern-Mérida
Current computer-aided detection (CADe) systems for contrast-enhanced breast MRI rely on both spatial information obtained from the early-phase and temporal information obtained from the late-phase of the contrast enhancement. However, late-phase information might not be available in a screening setting, such as in abbreviated MRI protocols, where acquisition is limited to early-phase scans. We used deep learning to develop a CADe system that exploits the spatial information obtained from the early-phase scans...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29339561/prepared-stimuli-enhance-aversive-learning-without-weakening-the-impact-of-verbal-instructions
#3
Lauren Y Atlas, Elizabeth A Phelps
Fear-relevant stimuli such as snakes and spiders are thought to capture attention due to evolutionary significance. Classical conditioning experiments indicate that these stimuli accelerate learning, while instructed extinction experiments suggest they may be less responsive to instructions. We manipulated stimulus type during instructed aversive reversal learning and used quantitative modeling to simultaneously test both hypotheses. Skin conductance reversed immediately upon instruction in both groups. However, fear-relevant stimuli enhanced dynamic learning, as measured by higher learning rates in participants conditioned with images of snakes and spiders...
February 2018: Learning & Memory
https://www.readbyqxmd.com/read/29337353/consumer-acceptance-comparison-between-seasoned-and-unseasoned-vegetables
#4
Yiming Feng, Marta Albiol Tapia, Kyle Okada, Nuria Blanca Castaneda Lazo, Karen Chapman-Novakofski, Carter Phillips, Soo-Yeun Lee
Recent findings show that approximately 87% of the U.S. population fail to meet the vegetable intake recommendations, with unpleasant taste of vegetables being listed as the primary reason for this shortfall. In this study, spice and herb seasoning was used to enhance palatability of vegetables, in order to increase consumer acceptance. In total, 749 panelists were screened and recruited as specific vegetable likers of the vegetable being tested or general vegetable likers. Four sessions were designed to evaluate the effect of seasoning within each type of vegetable, including broccoli, cauliflower, carrot, and green bean...
January 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29335360/activity-in-the-ventral-medial-prefrontal-cortex-is-necessary-for-the-therapeutic-effects-of-extinction-in-rats
#5
Elizabeth A Fucich, Denisse Paredes, Madeleine O Saunders, David A Morilak
Poor response and high relapse rates remain problematic in the treatment of stress-related psychiatric disorders like depression and posttraumatic stress disorder (PTSD). While mechanisms of pharmacotherapies are intensely studied, little is known about mechanisms of behavioral therapy that could inform improved treatments. We have previously demonstrated the therapeutic effects of extinction learning as a behavioral intervention modeling exposure therapy in rats. In the present study, we tested the hypothesis that activity in the ventral medial prefrontal cortex (vmPFC) during extinction is necessary for its therapeutic effects...
January 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29334651/effects-of-perinatal-fluoride-exposure-on-the-expressions-of-mir-124-and-mir-132-in-hippocampus-of-mouse-pups
#6
Jixiang Wang, Yuliang Zhang, Zhenzhen Guo, Rui Li, Xingchen Xue, Zilong Sun, Ruiyan Niu
To investigate the effects of perinatal fluoride exposure on learning and memory ability of mouse offspring, ICR female mice were received different doses of sodium fluoride (0, 25, 50, 100 mg/L NaF) from pregnant day 7 to lactational day 21. Pups were exposed to fluoride through the cord blood and breast milk. Open field test showed that compared to the control group, perinatal fluoride exposure significantly decreased the number of entries into the center zone in 100 mg/L NaF group. In the eight-arm maze test, the number of working memory errors, reference memory errors, and the total arm entries were significantly increased in fluoride treatment groups, compared to the control group...
January 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29329984/infralimbic-dopamine-d2-receptors-mediate-glucocorticoid-induced-facilitation-of-auditory-fear-memory-extinction-in-rats
#7
Masoumeh Dadkhah, Payman Raise Abdullahi, Ali Rashidy-Pour, Hamid Reza Sameni, Abbas Ali Vafaei
The infralimbic (IL) cortex of the medial prefrontal cortex plays an important role in the extinction of fear memory. Also, it has been showed that both brain glucocorticoid and dopamine receptors are involved in many processes such as fear extinction that drive learning and memory; however, the interaction of these receptors in the IL cortex remains unclear. We examined a putative interaction between the effects of glucocorticoid and dopamine receptors stimulation in the IL cortex on fear memory extinction in an auditory fear conditioning paradigm in male rats...
January 9, 2018: Brain Research
https://www.readbyqxmd.com/read/29329288/soil-transmitted-helminth-infection-loss-of-education-and-cognitive-impairment-in-school-aged-children-a-systematic-review-and-meta-analysis
#8
Noel Pabalan, Eloisa Singian, Lani Tabangay, Hamdi Jarjanazi, Michael J Boivin, Amara E Ezeamama
BACKGROUND: Evidence of an adverse influence of soil transmitted helminth (STH) infections on cognitive function and educational loss is equivocal. Prior meta-analyses have focused on randomized controlled trials only and have not sufficiently explored the potential for disparate influence of STH infection by cognitive domain. We re-examine the hypothesis that STH infection is associated with cognitive deficit and educational loss using data from all primary epidemiologic studies published between 1992 and 2016...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29327124/puerarin-up-regulates-methyl-cpg-binding-protein-2-phosphorylation-in-hippocampus-of-vascular-dementia-rats
#9
Hu-Qing Wang, Meng Zhang, Jia-Xin Zhao, Hai-Qin Wu, Zhen Gao, Gui-Lian Zhang, Ru Zhang
OBJECTIVE: To observe the effect of puerarin on methyl-CpG binding protein 2 (MeCP2) phosphorylation (pMeCP2) in the hippocampus of a rat model of vascular dementia (VD). METHODS: Thirty-six healthy Sprague-Dawley rats were randomly assigned to the sham-operated group, dementia group and puerarintreated group using a random number table (n=12 per group). The modifified permanent bilateral common carotid artery occlusion method was used to establish the VD model...
January 9, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29326103/understanding-the-complex-relationship-between-critical-thinking-and-science-reasoning-among-undergraduate-thesis-writers
#10
Jason E Dowd, Robert J Thompson, Leslie A Schiff, Julie A Reynolds
Developing critical-thinking and scientific reasoning skills are core learning objectives of science education, but little empirical evidence exists regarding the interrelationships between these constructs. Writing effectively fosters students' development of these constructs, and it offers a unique window into studying how they relate. In this study of undergraduate thesis writing in biology at two universities, we examine how scientific reasoning exhibited in writing (assessed using the Biology Thesis Assessment Protocol) relates to general and specific critical-thinking skills (assessed using the California Critical Thinking Skills Test), and we consider implications for instruction...
2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29325995/acetylshikonin-from-zicao-attenuates-cognitive-impairment-and-hippocampus-senescence-in-d-galactose-induced-aging-mouse-model-via-upregulating-the-expression-of-sirt1
#11
Qisen Li, Jiacheng Zeng, Meiling Su, Yu He, Banghao Zhu
Zicao acts as a pleiotropic medicine in various diseases due to its particular pharmacological properties, including anti-inflammatory, anti-tumor, anti-oxidative, and wound healing effects. However, few studies have focused on the function in neurodegenerative diseases of Zicao. In this study, we investigated the neuroprotective effect of Acetylshikonin (AS) from Zicao on the hippocampus of the D-galactose (D-gal)-induced sub-acute aging mouse model of Alzheimer's disease (AD). The aging model was established in male Kunming mice by subcutaneous injection of D-gal (150 mg/kg/d) for 60 days, and the mice were given AS (270, 540 and 1080 mg/kg/d) or distilled water intragastrically for 30 days after 30 days of D-gal injection...
January 8, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29324362/x-ray-system-simulation-software-tools-for-radiology-and-radiography-education
#12
Stephen M Kengyelics, Laura A Treadgold, Andrew G Davies
OBJECTIVES: To develop x-ray simulation software tools to support delivery of radiological science education for a range of learning environments and audiences including individual study, lectures, and tutorials. METHODS: Two software tools were developed; one simulated x-ray production for a simple two dimensional radiographic system geometry comprising an x-ray source, beam filter, test object and detector. The other simulated the acquisition and display of two dimensional radiographic images of complex three dimensional objects using a ray casting algorithm through three dimensional mesh objects...
December 13, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29316985/cognitive-enhancement-in-old-dogs-from-dietary-supplementation-with-a-nutrient-blend-containing-arginine-antioxidants-b-vitamins-and-fish-oil
#13
Yuanlong Pan, Adam D Kennedy, Thomas J Jönsson, Nortan W Milgram
This study focused on the hypothesis that cognitive decline in aged dogs could be attenuated by dietary supplementation with a nutrient blend consisting of antioxidants, B vitamins, fish oil and l-arginine, referred to hereafter as the Brain Protection Blend (BPB). Baseline cognitive assessment before the start of treatment was used to establish cognitively equivalent control (10·464+2·33 kg) and treatment (12·118+3·386 kg) groups of aged dogs between 9·1 and 11·5 years of age and with body condition score of 5...
January 10, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29316460/midwifery-education-and-technology-enhanced-learning-evaluating-online-story-telling-in-preregistration-midwifery-education
#14
Mandie Scamell, Thomas Hanley
BACKGROUND: A major issue regarding the implementation of blended learning for preregistration health programmes is the analysis of students' perceptions and attitudes towards their learning. It is the extent of the embedding of Technology Enhanced Learning (TEL) into the higher education curriculum that makes this analysis so vital. OBJECTIVES: This paper reports on the quantitative results of a UK based study that was set up to respond to the apparent disconnect between technology enhanced education provision and reliable student evaluation of this mode of learning...
December 8, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29314345/differentiation-between-vasogenic-edema-and-infiltrative-tumor-in-patients-with-high-grade-gliomas-using-texture-patch-based-analysis
#15
Moran Artzi, Gilad Liberman, Deborah T Blumenthal, Orna Aizenstein, Felix Bokstein, Dafna Ben Bashat
BACKGROUND: High-grade gliomas (HGGs) induce both vasogenic edema and extensive infiltration of tumor cells, both of which present with similar appearance on conventional MRI. Using current radiological criteria, differentiation between these tumoral and nontumoral areas within the nonenhancing lesion area remains challenging. PURPOSE: To use radiomics patch-based analysis, based on conventional MRI, for the classification of the nonenhancing lesion area in patients with HGG into tumoral and nontumoral components...
January 3, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29304864/hypercapnia-induces-il-1%C3%AE-overproduction-via-activation-of-nlrp3-inflammasome-implication-in-cognitive-impairment-in-hypoxemic-adult-rats
#16
Hong-Guang Ding, Yi-Yu Deng, Ren-Qiang Yang, Qiao-Sheng Wang, Wen-Qiang Jiang, Yong-Li Han, Lin-Qiang Huang, Miao-Yun Wen, Wen-Hong Zhong, Xu-Sheng Li, Fan Yang, Hong-Ke Zeng
BACKGROUND: Cognitive impairment is one of common complications of acute respiratory distress syndrome (ARDS). Increasing evidence suggests that interleukin-1 beta (IL-1β) plays a role in inducing neuronal apoptosis in cognitive dysfunction. The lung protective ventilatory strategies, which serve to reduce pulmonary morbidity for ARDS patients, almost always lead to hypercapnia. Some studies have reported that hypercapnia contributes to the risk of cognitive impairment and IL-1β secretion outside the central nervous system (CNS)...
January 5, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29303015/tests-of-the-attachment-and-developmental-dynamic-systems-theory-of-crime-addstoc-toward-a-differential-rdoc-diagnostic-and-treatment-approach
#17
Marc A Lindberg, Dana Zeid
The Attachment and Developmental Dynamic Systems Theory of Crime was tested on 206 male inmates. They completed measures tapping attachments, clinical issues, adverse childhood events, peer crime, and crime addictions. A significant path model was found, going from insecure parental attachments to adverse childhood events, and then on to the behavioral crime addiction and criminal peers scales. Peer crime was also predicted by insecure parent attachments and the crime addiction scale. Finally, the crime addiction, peer crime, and insecure parental attachment scales predicted frequencies of criminal behavior...
January 1, 2018: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29301667/impaired-value-learning-for-faces-in-preschoolers-with%C3%A2-autism-spectrum-disorder
#18
Quan Wang, Lauren DiNicola, Perrine Heymann, Michelle Hampson, Katarzyna Chawarska
OBJECTIVE: One of the common findings in autism spectrum disorder (ASD) is limited selective attention toward social objects, such as faces. Evidence from both human and nonhuman primate studies suggests that selection of objects for processing is guided by the appraisal of object values. We hypothesized that impairments in selective attention in ASD may reflect a disruption of a system supporting learning about object values in the social domain. METHOD: We examined value learning in social (faces) and nonsocial (fractals) domains in preschoolers with ASD (n = 25) and typically developing (TD) controls (n = 28), using a novel value learning task implemented on a gaze-contingent eye-tracking platform consisting of value learning and a selective attention choice test...
January 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29301545/personalized-upper-limb-training-combined-with-anodal-tdcs-for-sensorimotor-recovery-in-spastic-hemiparesis-study-protocol-for-a-randomized-controlled-trial
#19
Mindy F Levin, Melanie C Baniña, Silvi Frenkel-Toledo, Sigal Berman, Nachum Soroker, John M Solomon, Dario G Liebermann
BACKGROUND: Recovery of voluntary movement is a main rehabilitation goal. Efforts to identify effective upper limb (UL) interventions after stroke have been unsatisfactory. This study includes personalized impairment-based UL reaching training in virtual reality (VR) combined with non-invasive brain stimulation to enhance motor learning. The approach is guided by limiting reaching training to the angular zone in which active control is preserved ("active control zone") after identification of a "spasticity zone"...
January 4, 2018: Trials
https://www.readbyqxmd.com/read/29287793/the-protective-effect-of-20-s-protopanaxadiol-ppd-against-chronic-sleep-deprivation-csd-induced-memory-impairments-in-mice
#20
Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Liu
Sleep deprivation (SD) is associated with oxidative stress that causes learning and memory impairment. 20(S)-Protopanaxadiol (PPD), one of the protopanaxadiol-type saponins, has antioxidant and neuroprotective effect. This study was designed to research the protective effect of PPD against cognitive deficits induced by chronic sleep deprivation (CSD) in mice. The CSD model was induced by subjecting the mice to our self-made Sleep Interruption Apparatus (SIA) continuously for 14 days. The memory enhancing effects of PPD were evaluated by behavioral tests and the related mechanism was further explored by observing the oxidative stress changes in the cortex and hippocampus of mice...
December 26, 2017: Brain Research Bulletin
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