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https://www.readbyqxmd.com/read/28814056/design-of-a-lightweight-tethered-torque-controlled-knee-exoskeleton
#1
Kirby Ann Witte, Andreas M Fatschel, Steven H Collins
Lower-limb exoskeletons show promise for improving gait rehabilitation for those with chronic gait abnormalities due to injury, stroke or other illness. We designed and built a tethered knee exoskeleton with a strong lightweight frame and comfortable, four-point contact with the leg. The device is structurally compliant in select directions, instrumented to measure joint angle and applied torque, and is lightweight (0.76 kg). The exoskeleton is actuated by two off-board motors. Closed loop torque control is achieved using classical proportional feedback control with damping injection in conjunction with iterative learning...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813277/incredible-years-parenting-interventions-current-effectiveness-research-and-future-directions
#2
REVIEW
Frances Gardner, Patty Leijten
The Incredible Years parenting intervention is a social learning theory-based programme for reducing children's conduct problems. Dozens of randomized trials, many by independent investigators, find consistent effects of Incredible Years on children's conduct problems across multiple countries and settings. However, in common with other interventions, these average effects hide much variability in the responses of individual children and families. Innovative moderator research is needed to enhance scientific understanding of why individual children and parents respond differently to intervention...
June 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28810969/a-review-of-the-effectiveness-of-a-combat-and-operational-stress-control-restoration-center-in-afghanistan
#3
Jason L Judkins, Devvon L Bradley
BACKGROUND: The management of Combat and Operational Stress Reactions (COSR) within an operational environment is a multidimensional process. The aim is to help prevent behavioral health problems, preserve combat power, and increase return to duty rates for combat stress related casualties. In some COSR cases, enhanced services are required and the Combat and Operational Stress Control (COSC) Clinic refers Service Members (SMs) to the Freedom Restoration Clinic (FRC). The purpose was to describe a deployed restoration center in Afghanistan and examine the long-term effectiveness of those services...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28806936/enhancement-of-hepatitis-virus-immunoassay-outcome-predictions-in-imbalanced-routine-pathology-data-by-data-balancing-and-feature-selection-before-the-application-of-support-vector-machines
#4
Alice M Richardson, Brett A Lidbury
BACKGROUND: Data mining techniques such as support vector machines (SVMs) have been successfully used to predict outcomes for complex problems, including for human health. Much health data is imbalanced, with many more controls than positive cases. METHODS: The impact of three balancing methods and one feature selection method is explored, to assess the ability of SVMs to classify imbalanced diagnostic pathology data associated with the laboratory diagnosis of hepatitis B (HBV) and hepatitis C (HCV) infections...
August 14, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28806341/impact-of-cochlear-implantation-on-cognitive-functions-of-older-adults-pilot-test-results
#5
Dona M P Jayakody, Peter L Friedland, Esmeralda Nel, Ralph N Martins, Marcus D Atlas, Hamid R Sohrabi
BACKGROUND: A significant relationship between hearing loss and cognitive impairment has been previously reported. Overall, improvement in speech perception in quiet and quality of life has been observed after cochlear implantation. However, the impact of hearing loss treatment using cochlear implantation on cognitive functions is yet to be fully elucidated. OBJECTIVE: To investigate the impact of cochlear implantation on cognitive and psychological functions of older adults...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28804738/social-observation-task-in-a-linear-maze-for-rats
#6
Xiang Mou, Daoyun Ji
Animals often learn through observing their conspecifics. However, the mechanisms of them obtaining useful knowledge during observation are beginning to be understood. This protocol describes a novel social observation task to test the 'local enhancement theory', which proposes that presence of social subjects in an environment facilitates one's understanding of the environments. By combining behavior test and in vivo electrophysiological recording, we found that social observation can facilitate the observer's spatial representation of an unexplored environment...
July 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28802103/where-you-are-affects-what-you-can-easily-imagines-environmental-geometry-elicits-sensorimotor-interference-in-remote-perspective-taking
#7
Bernhard E Riecke, Timothy P McNamara
Imagined perspective switches are notoriously difficult, a fact often ascribed to sensorimotor interference between one's to-be-imagined versus actual orientation. Here, we demonstrate similar interference effects, even if participants know they are in a remote environment with unknown spatial relation to the learning environment. Participants learned 15 target objects irregularly arranged in an office from one orientation (0°, 120°, or 240°). Participants were blindfolded and disoriented before being wheeled to a test room of similar geometry (exp...
August 9, 2017: Cognition
https://www.readbyqxmd.com/read/28800501/learning-effects-of-dynamic-postural-control-by-auditory-biofeedback-versus-visual-biofeedback-training
#8
Naoya Hasegawa, Kenta Takeda, Moe Sakuma, Hiroki Mani, Hiroshi Maejima, Tadayoshi Asaka
Augmented sensory biofeedback (BF) for postural control is widely used to improve postural stability. However, the effective sensory information in BF systems of motor learning for postural control is still unknown. The purpose of this study was to investigate the learning effects of visual versus auditory BF training in dynamic postural control. Eighteen healthy young adults were randomly divided into two groups (visual BF and auditory BF). In test sessions, participants were asked to bring the real-time center of pressure (COP) in line with a hidden target by body sway in the sagittal plane...
August 2, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28798659/enhanced-data-representation-by-kernel-metric-learning-for-dementia-diagnosis
#9
David Cárdenas-Peña, Diego Collazos-Huertas, German Castellanos-Dominguez
Alzheimer's disease (AD) is the kind of dementia that affects the most people around the world. Therefore, an early identification supporting effective treatments is required to increase the life quality of a wide number of patients. Recently, computer-aided diagnosis tools for dementia using Magnetic Resonance Imaging scans have been successfully proposed to discriminate between patients with AD, mild cognitive impairment, and healthy controls. Most of the attention has been given to the clinical data, provided by initiatives as the ADNI, supporting reliable researches on intervention, prevention, and treatments of AD...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28797624/transcranial-direct-current-stimulation-over-multiple-days-enhances-motor-performance-of-a-grip-task
#10
Julie Fan, Julien Voisin, Marie-Hélène Milot, Johanne Higgins, Marie-Hélène Boudrias
BACKGROUND: Recovery of handgrip is critical after stroke since it is positively related to upper limb function. To boost motor recovery, transcranial direct current stimulation (tDCS) is a promising, non-invasive brain stimulation technique for the rehabilitation of persons with stroke. When applied over the primary motor cortex (M1), tDCS has been shown to modulate neural processes involved in motor learning. However, no studies have looked at the impact of tDCS on the learning of a grip task in both stroke and healthy individuals...
August 7, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28795411/does-ultrasound-enhanced-instruction-of-musculoskeletal-anatomy-improve-physical-examination-skills-of-first-year-medical-students
#11
Bryant J Walrod, Allison Schroeder, Mark J Conroy, Laura C Boucher, Marcia Bockbrader, David P Way, Kendra L McCamey, Clinton A Hartz, Michael A Jonesco, David P Bahner
OBJECTIVES: Ultrasound imaging is commonly used to teach basic anatomy to medical students. The purpose of this study was to determine whether learning musculoskeletal anatomy with ultrasound improved performance on medical students' musculoskeletal physical examination skills. METHODS: Twenty-seven first-year medical students were randomly assigned to 1 of 2 instructional groups: either shoulder or knee. Both groups received a lecture followed by hands-on ultrasound scanning on live human models of the assigned joint...
August 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28791547/data-based-prediction-of-blood-glucose-concentrations-using-evolutionary-methods
#12
J Ignacio Hidalgo, J Manuel Colmenar, Gabriel Kronberger, Stephan M Winkler, Oscar Garnica, Juan Lanchares
Predicting glucose values on the basis of insulin and food intakes is a difficult task that people with diabetes need to do daily. This is necessary as it is important to maintain glucose levels at appropriate values to avoid not only short-term, but also long-term complications of the illness. Artificial intelligence in general and machine learning techniques in particular have already lead to promising results in modeling and predicting glucose concentrations. In this work, several machine learning techniques are used for the modeling and prediction of glucose concentrations using as inputs the values measured by a continuous monitoring glucose system as well as also previous and estimated future carbohydrate intakes and insulin injections...
August 8, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28781946/hippocampus-dependent-task-improves-the-cognitive-function-after-ovariectomy-in-rats
#13
Songhee Cheon
OBJECTIVES: Estrogen is an important hormone for cell growth, development, and differentiation by transcriptional regulation and modulation of intracellular signaling via second messengers. The reduction in the estrogen level after ovariectomy may lead to cognitive impairments associated with morphological changes in areas of the brain mediate memory. The aim of the present study was to find out the effect of tasks on the cognitive function after ovariectomy in rats. METHODS: The animals used in the experiment were 50 Sprague-Dawley female rats...
June 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28781728/effect-of-play-based-therapy-on-meta-cognitive-and-behavioral-aspects-of-executive-function-a-randomized-controlled-clinical-trial-on-the-students-with-learning-disabilities
#14
Samaneh Karamali Esmaili, Narges Shafaroodi, Afsoon Hassani Mehraban, Akram Parand, Masoume Zarei, Saeed Akbari-Zardkhaneh
INTRODUCTION: Although the effect of educational methods on executive function (EF) is well known, training this function by a playful method is debatable. The current study aimed at investigating if a play-based intervention is effective on metacognitive and behavioral skills of EF in students with specific learning disabilities. METHODS: In the current randomized, clinical trial, 49 subjects within the age range of 7 to 11 years with specific learning disabilities were randomly assigned into the intervention (25 subjects; mean age 8...
May 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/28770893/effects-of-activity-repetition-training-with-salat-prayer-versus-task-oriented-training-on-functional-outcomes-of-stroke
#15
Misbah Ghous, Arshad Nawaz Malik, Mian Imran Amjad, Maria Kanwal
Stroke is one of most disabling condition which directly affects quality of life. The objective of this study was to compare the effect of activity repetition training with salat (prayer) versus task oriented training on functional outcomes of stroke. The study design was randomized control trial and 32 patients were randomly assigned into two groups'. The stroke including infarction or haemorrhagic, age bracket 30-70 years was included. The demographics were recorded and standardized assessment tool included Berg Balance Scale (BBS), Motor assessment scale (MAS) and Time Up and Go Test (TUG)...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28770474/in-silico-prediction-of-rock-ii-inhibitors-by-different-classification-approaches
#16
Chuipu Cai, Qihui Wu, Yunxia Luo, Huili Ma, Jiangang Shen, Yongbin Zhang, Lei Yang, Yunbo Chen, Zehuai Wen, Qi Wang
ROCK II is an important pharmacological target linked to central nervous system disorders such as Alzheimer's disease. The purpose of this research is to generate ROCK II inhibitor prediction models by machine learning approaches. Firstly, four sets of descriptors were calculated with MOE 2010 and PaDEL-Descriptor, and optimized by F-score and linear forward selection methods. In addition, four classification algorithms were used to initially build 16 classifiers with k-nearest neighbors [Formula: see text], naïve Bayes, Random forest, and support vector machine...
August 2, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28770387/data-to-decisions-creating-a-culture-of-model-driven-drug-discovery
#17
Frank K Brown, Farida Kopti, Charlie Zhenyu Chang, Scott A Johnson, Meir Glick, Chris L Waller
Merck & Co., Inc., Kenilworth, NJ, USA, is undergoing a transformation in the way that it prosecutes R&D programs. Through the adoption of a "model-driven" culture, enhanced R&D productivity is anticipated, both in the form of decreased attrition at each stage of the process and by providing a rational framework for understanding and learning from the data generated along the way. This new approach focuses on the concept of a "Design Cycle" that makes use of all the data possible, internally and externally, to drive decision-making...
August 2, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28767442/hydrogen-sulfide-ameliorates-cognitive-dysfunction-in-streptozotocin-induced-diabetic-rats-involving-suppression-in-hippocampal-endoplasmic-reticulum-stress
#18
Wei Zou, Juan Yuan, Zhuo-Jun Tang, Hai-Jun Wei, Wei-Wen Zhu, Ping Zhang, Hong-Feng Gu, Chun-Yan Wang, Xiao-Qing Tang
Diabetes induces impairment in cognitive function. There is substantial evidence that hippocampal endoplasmic reticulum (ER) stress is involved in diabetic cognitive impairment. Hydrogen sulfide (H2S) attenuates the learning and memory decline in experimental Alzheimer's disease and inhibits the hippocampal ER stress in homocysteine-exposed rats. Therefore, this aim of the present work was to investigate whether H2S ameliorates the diabetic cognitive dysfunction involving inhibition of hippocampal ER stress...
July 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28765331/visual-perceptual-echo-reflects-learning-of-regularities-in-rapid-luminance-sequences
#19
Acer Y-C Chang, David J Schwartzman, Rufin VanRullen, Ryota Kanai, Anil K Seth
A novel neural signature of active visual processing has recently been described in the form of the 'perceptual echo', in which the cross-correlation between a sequence of randomly fluctuating luminance values and occipital electrophysiological (EEG) signals exhibits a long-lasting periodic (∼100ms cycle) reverberation of the input stimulus (VanRullen & Macdonald, 2012). As yet, however, the mechanisms underlying the perceptual echo and its function remain unknown. Reasoning that natural visual signals often contain temporally predictable, though non-periodic features, we hypothesized that the perceptual echo may reflect a periodic process associated with regularity learning...
August 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28764869/intelligent-computational-model-for-classification-of-sub-golgi-protein-using-oversampling-and-fisher-feature-selection-methods
#20
Jamal Ahmad, Faisal Javed, Maqsood Hayat
Golgi is one of the core proteins of a cell, constitutes in both plants and animals, which is involved in protein synthesis. Golgi is responsible for receiving and processing the macromolecules and trafficking of newly processed protein to its intended destination. Dysfunction in Golgi protein is expected to cause many neurodegenerative and inherited diseases that may be cured well if they are detected effectively and timely. Golgi protein is categorized into two parts cis-Golgi and trans-Golgi. The identification of Golgi protein via direct method is very hard due to limited available recognized structures...
May 2017: Artificial Intelligence in Medicine
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