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https://www.readbyqxmd.com/read/27926742/modeling-deficits-from-early-auditory-information-processing-to-psychosocial-functioning-in-schizophrenia
#1
Michael L Thomas, Michael F Green, Gerhard Hellemann, Catherine A Sugar, Melissa Tarasenko, Monica E Calkins, Tiffany A Greenwood, Raquel E Gur, Ruben C Gur, Laura C Lazzeroni, Keith H Nuechterlein, Allen D Radant, Larry J Seidman, Alexandra L Shiluk, Larry J Siever, Jeremy M Silverman, Joyce Sprock, William S Stone, Neal R Swerdlow, Debby W Tsuang, Ming T Tsuang, Bruce I Turetsky, David L Braff, Gregory A Light
Importance: Neurophysiologic measures of early auditory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers in clinical intervention studies. Research in schizophrenia has established correlations among measures of EAP, cognition, clinical symptoms, and functional outcome. Clarifying these associations by determining the pathways through which deficits in EAP affect functioning would suggest when and where to therapeutically intervene. Objectives: To characterize the pathways from EAP to outcome and to estimate the extent to which enhancement of basic information processing might improve cognition and psychosocial functioning in schizophrenia...
December 7, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27924874/context-and-auditory-fear-are-differentially-regulated-by-hdac3-activity-in-the-lateral-and-basal-subnuclei-of-the-amygdale
#2
Janine L Kwapis, Yasaman Alaghband, Alberto J López, André O White, Rianne R Campbell, Richard T Dang, Diane Rhee, Ashley V Tran, Allison E Carl, Dina P Matheos, Marcelo A Wood
Histone acetylation is a fundamental epigenetic mechanism that is dynamically regulated during memory formation. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) compete to modulate histone acetylation, allowing for rapid changes in acetylation in response to a learning event. HDACs are known to be powerful negative regulators of memory formation, but it is not clear whether this function depends on HDAC enzymatic activity per se. Here, we tested whether the enzymatic activity of an individual Class I HDAC, HDAC3, plays a role in fear memory formation in subregions of the hippocampus and amygdala...
December 7, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27924046/new-data-and-features-for-advanced-data-mining-in-manteia
#3
Olivier Tassy
Manteia is an integrative database available online at http://manteia.igbmc.fr which provides a large array of OMICs data related to the development of the mouse, chicken, zebrafish and human. The system is designed to use different types of data together in order to perform advanced datamining, test hypotheses or provide candidate genes involved in biological processes or responsible for human diseases. In this new version of the database, Manteia has been enhanced with new expression data originating from microarray and next generation sequencing experiments...
October 24, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27923662/task-specificity-of-unilateral-anodal-and-dual-m1-tdcs-effects-on-motor-learning
#4
Sophia Karok, David Fletcher, Alice G Witney
Task-specific effects of transcranial direct current stimulation (tDCS) on motor learning were investigated in 30 healthy participants. In a sham-controlled, mixed design, participants trained on 3 different motor tasks (Purdue Pegboard Test, Visuomotor Grip Force Tracking Task and Visuomotor Wrist Rotation Speed Control Task) over 3 consecutive days while receiving either unilateral anodal over the right primary motor cortex (M1), dual-M1 or sham stimulation. Retention sessions were administered 7 and 28 days after the end of training...
December 3, 2016: Neuropsychologia
https://www.readbyqxmd.com/read/27923162/comparison-of-different-osmotic-therapies-in-a-mouse-model-of-traumatic-brain-injury
#5
Vinoth K M Khandelwal, Prabhakar Singh, Tatiana Ravingerova, Marslin Gregory, Hardik Gandhi, Manu Chaudhary
BACKGROUND: Inflammation in the affected region, increased intracranial pressure, consequent oedema and congestion contribute to the negative outcome of traumatic brain injury. Osmotic therapies are recommended for improvement in cognitive and motor functions. Aim of the present study was to evaluate the effect of osmotic therapies in a mice model of traumatic brain injury. METHODS: Experimental closed head injury was performed in adult Swiss albino mice by the weight-drop method...
October 11, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27922727/measuring-learning-gain-comparing-anatomy-drawing-screencasts-and-paper-based-resources
#6
James D Pickering
The use of technology-enhanced learning (TEL) resources is now a common tool across a variety of healthcare programs. Despite this popular approach to curriculum delivery there remains a paucity in empirical evidence that quantifies the change in learning gain. The aim of the study was to measure the changes in learning gain observed with anatomy drawing screencasts in comparison to a traditional paper-based resource. Learning gain is a widely used term to describe the tangible changes in learning outcomes that have been achieved after a specific intervention...
December 6, 2016: Anatomical Sciences Education
https://www.readbyqxmd.com/read/27920957/eurasian-jays-do-not-copy-the-choices-of-conspecifics-but-they-do-show-evidence-of-stimulus-enhancement
#7
Rachael Miller, Corina J Logan, Katherine Lister, Nicola S Clayton
Corvids (birds in the crow family) are hypothesised to have a general cognitive tool-kit because they show a wide range of transferrable skills across social, physical and temporal tasks, despite differences in socioecology. However, it is unknown whether relatively asocial corvids differ from social corvids in their use of social information in the context of copying the choices of others, because only one such test has been conducted in a relatively asocial corvid. We investigated whether relatively asocial Eurasian jays (Garrulus glandarius) use social information (i...
2016: PeerJ
https://www.readbyqxmd.com/read/27920794/dance-experience-and-associations-with-cortical-gray-matter-thickness-in-the-aging-population
#8
Shai Porat, Naira Goukasian, Kristy S Hwang, Theodore Zanto, Triet Do, Jonathan Pierce, Shantanu Joshi, Ellen Woo, Liana G Apostolova
INTRODUCTION: We investigated the effect dance experience may have on cortical gray matter thickness and cognitive performance in elderly participants with and without mild cognitive impairment (MCI). METHODS: 39 cognitively normal and 48 MCI elderly participants completed a questionnaire regarding their lifetime experience with music, dance, and song. Participants identified themselves as either dancers or nondancers. All participants received structural 1.5-tesla MRI scans and detailed clinical and neuropsychological evaluations...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/27920146/selectivity-in-post-encoding-connectivity-with-high-level-visual-cortex-is-associated-with-reward-motivated-memory
#9
Vishnu P Murty, Alexa Tompary, R Alison Adcock, Lila Davachi
: Reward motivation has been demonstrated to enhance declarative memory by facilitating systems level consolidation. While high reward information is often intermixed with lower reward information during an experience, memory for those experiences prioritizes high value information. How is this selectivity achieved? One possibility is that post-encoding consolidation processes bias memory strengthening to those representations associated with higher reward. To test this hypothesis, we investigated the influence of differential reward motivation on the selectivity of post-encoding markers of systems-level memory consolidation...
December 5, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27918787/an-ovine-model-for-exclusive-endoscopic-ear-surgery
#10
Lukas Anschuetz, Marco Bonali, Michael Ghirelli, Francesco Mattioli, Domenico Villari, Marco Caversaccio, Livio Presutti
Importance: With the international spread of exclusive transcanal endoscopic ear surgery, the need for a suitable and affordable surgical training model has grown during the past years. Objective: To develop and validate an ex vivo animal model for exclusive endoscopic ear surgery. Design, Setting, and Animal Models: In an experimental study, we compared ovine and human middle ear anatomy in 4 specimens and assessed the lamb as a model for endoscopic ear surgery...
December 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27918079/high-intensity-treadmill-running-impairs-cognitive-behavior-and-hippocampal-synaptic-plasticity-of-rats-via-activation-of-inflammatory-response
#11
Li-Na Sun, Xiao-Long Li, Fei Wang, Jun Zhang, Dan-Dan Wang, Li Yuan, Mei-Na Wu, Zhao-Jun Wang, Jin-Shun Qi
Although appropriate exercise is beneficial for enhancing brain functions, high-intensity exercise (HIE)-induced cognitive dysfunction is causing more and more concerns nowadays. In the present study, we observed the effects of high-intensity treadmill running on the spatial learning of the adult Sprague Dawley male rats in Y-maze (n = 16 per group), and investigated its possible electrophysiological and molecular mechanisms by examining in vivo hippocampal long-term potentiation (LTP), central inflammatory responses, and JNK/p38/ERK signal pathway...
December 5, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27916362/effectiveness-of-a-mental-skills-curriculum-to-reduce-novices-stress
#12
Nicholas E Anton, Lisa D Howley, Manuel Pimentel, Cameron K Davis, Charles Brown, Dimitrios Stefanidis
BACKGROUND: Stress has been shown to negatively impact surgical performance, and surgical novices are particularly susceptible to its effects. Mental skills are psychological strategies designed to enhance performance and reduce the impact of stress to consistently facilitate the ideal mental conditions that enable performers to perform their best. Mental skills have been used routinely in other high-stress domains (e.g., with Navy SEALs, military pilots, elite athletes, and so forth) to facilitate optimal performance in challenging situations...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27915477/treadmill-exercise-improves-memory-function-depending-on-circadian-rhythm-changes-in-mice
#13
Dong Sup Hwang, Hyo Bum Kwak, Il Gyu Ko, Sung Eun Kim, Jun Jang Jin, Eun Sang Ji, Hyun Hee Choi, Oh Young Kwon
PURPOSE: Exercise enhances memory function by increasing neurogenesis in the hippocampus, and circadian rhythms modulate synaptic plasticity in the hippocampus. The circadian rhythm-dependent effects of treadmill exercise on memory function in relation with neurogenesis were investigated using mice. METHODS: The step-down avoidance test was used to evaluate short-term memory, the 8-arm maze test was used to test spatial learning ability, and 5-bromo-2'-deoxyuridine immunofluorescence was used to assess neurogenesis...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27913715/doping-among-professional-athletes-in-iran-a-test-of-akers-s-social-learning-theory
#14
Saeed Kabiri, John K Cochran, Bernadette J Stewart, Mahmoud Sharepour, Mohammad Mahdi Rahmati, Syede Massomeh Shadmanfaat
The use of performance-enhancing drugs (PED) is common among Iranian professional athletes. As this phenomenon is a social problem, the main purpose of this research is to explain why athletes engage in "doping" activity, using social learning theory. For this purpose, a sample of 589 professional athletes from Rasht, Iran, was used to test assumptions related to social learning theory. The results showed that there are positive and significant relationships between the components of social learning theory (differential association, differential reinforcement, imitation, and definitions) and doping behavior (past, present, and future use of PED)...
December 1, 2016: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/27913599/the-effect-of-food-quality-during-growth-on-spatial-memory-consolidation-in-adult-pigeons
#15
M F Scriba, J Gasparini, L Jacquin, C Mettke-Hofmann, N C Rattenborg, A Roulin
Poor environmental conditions experienced during early development can have negative long-term consequences on fitness. Animals can compensate negative developmental effects through phenotypic plasticity by diverting resources from non-vital to vital traits such as spatial memory to enhance foraging efficiency. We tested in young feral pigeons (Columba livia) how diets of different nutritional value during development affect the capacity to retrieve food hidden in a spatially complex environment, a process we refer to as "spatial memory"...
December 2, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27913371/multiview-convolutional-neural-networks-for-multidocument-extractive-summarization
#16
Yong Zhang, Meng Joo Er, Rui Zhao, Mahardhika Pratama
Multidocument summarization has gained popularity in many real world applications because vital information can be extracted within a short time. Extractive summarization aims to generate a summary of a document or a set of documents by ranking sentences and the ranking results rely heavily on the quality of sentence features. However, almost all previous algorithms require hand-crafted features for sentence representation. In this paper, we leverage on word embedding to represent sentences so as to avoid the intensive labor in feature engineering...
November 28, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27909312/the-association-between-physical-activity-during-the-day-and-long-term-memory-stability
#17
Matthew B Pontifex, Kathryn L Gwizdala, Andrew C Parks, Karin A Pfeiffer, Kimberly M Fenn
Despite positive associations between chronic physical activity and memory; we have little understanding of how best to incorporate physical activity during the day to facilitate the consolidation of information into memory, nor even how time spent physically active during the day relates to memory processes. The purpose of this investigation was to examine the relation between physical activity during the day and long-term memory. Ninety-two young adults learned a list of paired-associate items and were tested on the items after a 12-hour interval during which heart rate was recorded continuously...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27908167/computer-aided-prognosis-for-cell-death-categorization-and-prediction-in-vivo-using-quantitative-ultrasound-and-machine-learning-techniques
#18
M J Gangeh, A Hashim, A Giles, L Sannachi, G J Czarnota
PURPOSE: At present, a one-size-fits-all approach is typically used for cancer therapy in patients. This is mainly because there is no current imaging-based clinical standard for the early assessment and monitoring of cancer treatment response. Here, the authors have developed, for the first time, a complete computer-aided-prognosis (CAP) system based on multiparametric quantitative ultrasound (QUS) spectroscopy methods in association with texture descriptors and advanced machine learning techniques...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27907980/flipped-clinical-training-a-structured-training-method-for-undergraduates-in-complete-denture-prosthesis
#19
Anbarasi K, Kasim Mohamed K, Phagalvarthy Vijayaraghavan, Deivanayagam Kandaswamy
PURPOSE: To design and implement flipped clinical training for undergraduate dental students in removable complete denture treatment and predict its effectiveness by comparing the assessment results of students trained by flipped and traditional methods. METHODS: Flipped training was designed by shifting the learning from clinics to learning center (phase I) and by preserving the practice in clinics (phase II). In phase I, student-faculty interactive session was arranged to recap prior knowledge...
December 2016: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/27906033/the-role-of-the-backbone-torsion-in-protein-folding
#20
EDITORIAL
Irina Sorokina, Arcady Mushegian
BACKGROUND: The set of forces and sequence of events that govern the transition from an unfolded polypeptide chain to a functional protein with correct spatial structure remain incompletely known, despite the importance of the problem and decades of theory development, computer simulations, and laboratory experiments. Information about the correctly folded state of most proteins is likely to be present in their sequences, and yet many proteins fail to attain native structure after overexpression in a non-native environment or upon experimental denaturation and refolding...
December 1, 2016: Biology Direct
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