keyword
MENU ▼
Read by QxMD icon Read
search

Panax ginseng

keyword
https://www.readbyqxmd.com/read/29049369/discrimination-and-prediction-of-cultivation-age-and-parts-of-panax-ginseng-by-fourier-transform-infrared-spectroscopy-combined-with-multivariate-statistical-analysis
#1
Byeong-Ju Lee, Hye-Youn Kim, Sa Rang Lim, Linfang Huang, Hyung-Kyoon Choi
Panax ginseng C.A. Meyer is a herb used for medicinal purposes, and its discrimination according to cultivation age has been an important and practical issue. This study employed Fourier-transform infrared (FT-IR) spectroscopy with multivariate statistical analysis to obtain a prediction model for discriminating cultivation ages (5 and 6 years) and three different parts (rhizome, tap root, and lateral root) of P. ginseng. The optimal partial-least-squares regression (PLSR) models for discriminating ginseng samples were determined by selecting normalization methods, number of partial-least-squares (PLS) components, and variable influence on projection (VIP) cutoff values...
2017: PloS One
https://www.readbyqxmd.com/read/29048480/panax-ginseng-genome-examination-for-ginsenoside-biosynthesis
#2
Xu Jiang, Chu Yang, Liao Baosheng, Xiao Shuiming, Yin Qinggang, Bai Rui, Su He, Dong Linlin, Li Xiwen, Qian Jun, Zhang Jingjing, Zhang Yujun, Zhang Xiaoyan, Wu Mingli, Zhang Jie, Li Guozheng, Zhang Lei, Chang Zhenzhan, Zhang Yuebin, Jia Zhengwei, Liu Zhixiang, Daniel Afreh, Ruth Nahurira, Zhang Lianjuan, Cheng Ruiyang, Zhu Yingjie, Zhu Guangwei, Rao Wei, Zhou Chao, Qiao Lirui, Huang Zhihai, Cheng Yung-Chi, Chen Shilin
Background: Ginseng, which contain ginsenosides as bioactive compounds, has been regarded as an important traditional medicine for several millennia. However, the genetic background of ginseng remains poorly understood partly because of the plant's large and complex genome composition. Results: We report the entire genome sequence of Panax ginseng using next-generation sequencing. The 3.5Gb nucleotide sequence contained more than 60% repeats and encoded 42,006 predicted genes...
October 5, 2017: GigaScience
https://www.readbyqxmd.com/read/29031195/ginsenoside-rg3-attenuates-cisplatin-resistance-in-lung-cancer-by-downregulating-pd-l1-and-resuming-immune
#3
Zhansheng Jiang, Yanfang Yang, Yinli Yang, Yu Zhang, Zhensong Yue, Zhanyu Pan, Xiubao Ren
Programmed death ligand 1 (PD-L1) as one the most important immune checkpoint was verified to involve in chemotherapy resistance in non-small cell lung cancer (NSCLC). Ginsenoside Rg3 is isolated from Chinese herb-Panax ginseng which is recognized to boost immune and has anti-cancer activity against a majority of carcinomas including NSCLC. In this study, we aim to identify whether Rg3 could attenuate the PD-L1 expression induced by resistance to cisplatin and draw out the underlying mechanisms of PD-L1 in this process...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29027428/-gene-cloning-and-expression-analysis-of-benzoic-acid-stress-responsive-transcription-factor-wrky7-in-panax-ginseng
#4
Zi Wang, Yong Li, Rong Wang, Wan-Long Ding
WRKY transcription factor is one of the most important transcription factor families widely existing in higher plants, which playing critical role in plant morphogenesis, development, biotic (including phytopathogens, pests etc.) and abiotic (drought, salt, chilling, high temperature, etc.) stress. In the present work, primers used to amplify full-length gene encoding WRKY transcription factor were designed based on the transcriptome data of P. ginseng that induced by benzoic acid, one of the most important autotoxins identified from root exudates and rhizosphere soil of P...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29021711/ginsenoside-rg1-from-panax-ginseng-enhances-myoblast-differentiation-and-myotube-growth
#5
Ga-Yeon Go, Sang-Jin Lee, Ayoung Jo, Jaecheol Lee, Dong-Wan Seo, Jong-Sun Kang, Si-Kwan Kim, Su-Nam Kim, Yong Kee Kim, Gyu-Un Bae
BACKGROUND: Ginsenoside Rg1 belongs to protopanaxatriol-type ginsenosides and has diverse pharmacological activities. In this report, we investigated whether Rg1 could upregulate muscular stem cell differentiation and muscle growth. METHODS: C2C12 myoblasts, MyoD-transfected 10T1/2 embryonic fibroblasts, and HEK293T cells were treated with Rg1 and differentiated for 2 d, subjected to immunoblotting, immunocytochemistry, or immunoprecipitation. RESULTS: Rg1 activated promyogenic kinases, p38MAPK (mitogen-activated protein kinase) and Akt signaling, that in turn promote the heterodimerization with MyoD and E proteins, resulting in enhancing myogenic differentiation...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021710/melanogenesis-inhibition-activity-of-floralginsenoside-a-from-panax-ginseng-berry
#6
Dae Young Lee, Jongsung Lee, Yong Tae Jeong, Geon Hee Byun, Jin Hee Kim
BACKGROUND: Panax ginseng is a traditional herb used for medicinal purposes in eastern Asia. P. ginseng contains various ginsenosides with pharmacological effects. In this study, floralginsenoside A (FGA), ginsenoside Rd (GRD), and ginsenoside Re (GRE) were purified from P. ginseng berry. METHODS: Chemical structures of FGA, GRD, and GRE were determined based on spectroscopic methods, including fast atom bombardment mass spectroscopy, ID-nuclear magnetic resonance, and infrared spectroscopy...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021707/pectinase-treated-panax-ginseng-protects-against-chronic-intermittent-heat-stress-induced-testicular-damage-by-modulating-hormonal-and-spermatogenesis-related-molecular-expression-in-rats
#7
Spandana Rajendra Kopalli, Kyu-Min Cha, Sang-Ho Lee, Ji-Hoon Ryu, Seock-Yeon Hwang, Min-Sik Jeong, Jong-Hwan Sung, Si-Kwan Kim
BACKGROUND: Elevated testicular temperature disrupts spermatogenesis and causes infertility. In the present study, the protective effect of enzymatically biotransformed Panax ginseng Meyer by pectinase (GINST) against chronic intermittent heat stress-induced testicular damage in rats was investigated. METHODS: Male Sprague-Dawley rats (4 wk old, 60-70 g) were divided into four groups: normal control (NC), heat-stress control (HC), heat-stress plus GINST-100 mg/kg (HG100), and heat-stress plus GINST-200 mg/kg (HG200) treatment groups...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021706/effect-of-hydrothermal-processing-on-ginseng-extract
#8
Jebin Ryu, Hun Wook Lee, Junho Yoon, Bumjoon Seo, Dong Eui Kwon, Un-Moo Shin, Kwang-Joon Choi, Youn-Woo Lee
BACKGROUND: Panax ginseng Meyer is cultivated because of its medicinal effects on the immune system, blood pressure, and cancer. Major ginsenosides in fresh ginseng are converted to minor ginsenosides by structural changes such as hydrolysis and dehydration. The transformed ginsenosides are generally more bioavailable and bioactive than the primary ginsenosides. Therefore, in this study, hydrothermal processing was applied to ginseng preparation to increase the yields of the transformed ginsenosides, such as 20(S)-Rg3, Rk1, and Rg5, and enhance antioxidant activities in an effective way...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021702/biotransformation-of-panax-ginseng-extract-by-rat-intestinal-microflora-identification-and-quantification-of-metabolites-using-liquid-chromatography-tandem-mass-spectrometry
#9
Wei-Wei Dong, Jinhua Zhao, Fei-Liang Zhong, Wen-Jing Zhu, Jun Jiang, Songquan Wu, Deok-Chun Yang, Donghao Li, Lin-Hu Quan
BACKGROUND: In general, after Panax ginseng is administered orally, intestinal microbes play a crucial role in its degradation and metabolization process. Studies on the metabolism of P. ginseng by microflora are important for obtaining a better understanding of their biological effects. METHODS: In vitro biotransformation of P. ginseng extract by rat intestinal microflora was investigated at 37°C for 24 h, and the simultaneous determination of the metabolites and metabolic profile of P...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021700/ginsenoside-rg12-a-new-dammarane-type-triterpene-saponin-from-panax-ginseng-root
#10
Dong Gu Lee, Jaemin Lee, Ik-Hyun Cho, Hak-Jae Kim, Sang-Won Lee, Young-Ock Kim, Chun-Gun Park, Sanghyun Lee
BACKGROUND: Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects. METHODS: A dammarane-type triterpene saponin was isolated from P. ginseng root through chromatography such as repeated column chromatography and medium pressure liquid chromatography. RESULTS AND CONCLUSION: New dammarane-type triterpene saponin was isolated for the first time from nature...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021699/evaluation-of-ginsenoside-bioconversion-of-lactic-acid-bacteria-isolated-from-kimchi
#11
Boyeon Park, Hyelyeon Hwang, Jina Lee, Sung-Oh Sohn, Se Hee Lee, Min Young Jung, Hyeong In Lim, Hae Woong Park, Jong-Hee Lee
BACKGROUND: Panax ginseng is a physiologically active plant widely used in traditional medicine that is characterized by the presence of ginsenosides. Rb1, a major ginsenoside, is used as the starting material for producing ginsenoside derivatives with enhanced pharmaceutical potentials through chemical, enzymatic, or microbial transformation. METHODS: To investigate the bioconversion of ginsenoside Rb1, we prepared kimchi originated bacterial strains Leuconostoc mensenteroides WiKim19, Pediococcus pentosaceus WiKim20, Lactobacillus brevis WiKim47, Leuconostoc lactis WiKim48, and Lactobacillus sakei WiKim49 and analyzed bioconversion products using LC-MS/MS mass spectrometer...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021696/antiviral-activity-of-20-r-ginsenoside-rh2-against-murine-gammaherpesvirus
#12
Soowon Kang, Kyungtaek Im, Geon Kim, Hyeyoung Min
BACKGROUND: Ginsenosides are the major components of Panax ginseng Meyer, an herbal medicine used for the treatment of various diseases. Different ginsenosides contribute to the biological properties of ginseng, such as antimicrobial, anticancer, and immunomodulatory properties. In this study, we investigated the antiviral effects of 15 ginsenosides and compound K on gammaherpesvirus. METHODS: The antiviral activity of ginsenosides was examined using the plaque-forming assay and by analyzing the expression of the lytic gene...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021695/chemical-and-bioactive-comparison-of-flowers-of-panax-ginseng-meyer-panax-quinquefolius-l-and-panax-notoginseng-burk
#13
Fang Li, Chongning Lv, Qiao Li, Jing Wang, Dan Song, Pengpeng Liu, Dandan Zhang, Jincai Lu
BACKGROUND: Although flowers of Panax ginseng Meyer (FPG), Panax quinquefolius L. (FPQ), and Panax notoginseng Burk. (FPN) have been historically used as both medicine and food, each is used differently in practice. METHODS: To investigate the connection between components and enhancing immunity activity of FPG, FPQ, and FPN, a method based on a rapid LC coupled with quadrupole time-of-flight MS and immunomodulatory activity study evaluated by a carbon clearance test were combined...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021693/a-refined-panax-ginseng-karyotype-based-on-an-ultra-high-copy-167-bp-tandem-repeat-and-ribosomal-dnas
#14
Nomar Espinosa Waminal, Hong-Il Choi, Nam-Hoon Kim, Woojong Jang, Junki Lee, Jee Young Park, Hyun Hee Kim, Tae-Jin Yang
BACKGROUND: Panax ginseng Meyer (Asian ginseng) has a large nuclear genome size of > 3.5 Gbp in haploid genome equivalent of 24 chromosomes. Tandem repeats (TRs) occupy significant portions of the genome in many plants and are often found in specific genomic loci, making them a valuable molecular cytogenetic tool in discriminating chromosomes. In an effort to understand the P. ginseng genome structure, we characterized an ultrahigh copy 167-bp TR (Pg167TR) and explored its chromosomal distribution as well as its utility for chromosome identification...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021692/cytohistological-study-of-the-leaf-structures-of-panax-ginseng-meyer-and-panax-quinquefolius-l
#15
Ok Ran Lee, Ngoc Quy Nguyen, Kwang Ho Lee, Young Chang Kim, Jiho Seo
BACKGROUND: Both Panax ginseng Meyer and Panax quinquefolius are obligate shade-loving plants whose natural habitats are broadleaved forests of Eastern Asia and North America. Panax species are easily damaged by photoinhibition when they are exposed to high temperatures or insufficient shade. In this study, a cytohistological study of the leaf structures of two of the most well-known Panax species was performed to better understand the physiological processes that limit photosynthesis...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021689/applications-of-molecular-markers-in-the-discrimination-of-panax-species-and-korean-ginseng-cultivars-panax-ginseng
#16
REVIEW
Ick Hyun Jo, Young Chang Kim, Dong Hwi Kim, Kee Hong Kim, Tae Kyung Hyun, Hojin Ryu, Kyong Hwan Bang
The development of molecular markers is one of the most useful methods for molecular breeding and marker-based molecular associated selections. Even though there is less information on the reference genome, molecular markers are indispensable tools for determination of genetic variation and identification of species with high levels of accuracy and reproducibility. The demand for molecular approaches for marker-based breeding and genetic discriminations in Panax species has greatly increased in recent times and has been successfully applied for various purposes...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021688/role-of-ginsenosides-the-main-active-components-of-panax-ginseng-in-inflammatory-responses-and-diseases
#17
REVIEW
Ji Hye Kim, Young-Su Yi, Mi-Yeon Kim, Jae Youl Cho
Panax ginseng is one of the most universally used herbal medicines in Asian and Western countries. Most of the biological activities of ginseng are derived from its main constituents, ginsenosides. Interestingly, a number of studies have reported that ginsenosides and their metabolites/derivatives-including ginsenoside (G)-Rb1, compound K, G-Rb2, G-Rd, G-Re, G-Rg1, G-Rg3, G-Rg5, G-Rh1, G-Rh2, and G-Rp1-exert anti-inflammatory activities in inflammatory responses by suppressing the production of proinflammatory cytokines and regulating the activities of inflammatory signaling pathways, such as nuclear factor-κB and activator protein-1...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28994528/-research-progress-on-regulation-effect-of-panax-notoginseng-saponins-on-mitochondria
#18
REVIEW
Zi-Ping Yang, Yi-Min Bao
Mitochondria is the key energy source of cells and plays an important role in energy synthesis and release, and maintenance of cellular functions. As the most important active ingredients in Chinese medicine pseudo-ginseng, Panax notoginseng saponins(PNS) have pharmacological effects on protecting against thrombosis, dilating blood vessels, lowering the blood pressure, anti-inflammation, and antioxidant, etc. Domestic and foreign studies have shown that PNS participates in regulating mitochondrial energy metabolism, oxidative stress, biosynthesis, apoptosis, mitophagy and the status of membrane channels...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28986996/metabolite-profiling-of-ginsenosides-in-rat-plasma-urine-and-faeces-by-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study-after-oral-administration-of-panax-ginseng-extract
#19
Wei-Wei Dong, Xiong-Zhe Han, Jinhua Zhao, Fei-Liang Zhong, Rui Ma, Songquan Wu, Donghao Li, Lin-Hu Quan, Jun Jiang
Panax ginseng has been widely consumed as a functional food in the form of tea, powder, capsules, among others, and possesses a range of pharmacological activities including adaptogenic, immune-modulatory, anti-tumour, anti-aging, and anti-inflammatory effects. The aim of this study was to identify and quantify the major ginsenosides and their metabolites in rat plasma, urine, and faeces after administration of Panax ginseng extract by using LC-MS/MS. We collected rat plasma samples at 0.5, 1, 2, 4, 8, 12, 24, and 48 h, and the amounts of urine and faecal samples accumulated in 24 h...
October 7, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28977419/uplc-orbitrap-hrms-analysis-of-panax-quinquefolium-l-for-authentication-of-panax-genus-with-chemometric-methods
#20
Xin Huang, Yan Liu, Nan Zhang, Xiuli Sun, Hao Yue, Changbao Chen, Shuying Liu
Ginsenosides in Panax quinquefolium L. were determined using developed ultra-performance liquid chromatography coupled to high resolution mass spectrometry (UPLC-HRMS) method with electrospray ionization and orbitrap MS analyzer in negative ionization mode. Optimal UPLC separation was achieved using a mixture of acetonitrile and water with 0.1% formic acid as the mobile phase in linear gradient elution. The MS parameters were optimized for reliable detection with enhanced selectivity and sensitivity, and improved identification and quantification of ginsenosides...
August 31, 2017: Journal of Chromatographic Science
keyword
keyword
9274
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"