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Panax ginseng

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https://www.readbyqxmd.com/read/28078264/comparison-of-ginsenoside-contents-in-different-parts-of-korean-ginseng-panax-ginseng-c-a-meyer
#1
Ok-Ju Kang, Ji-Sang Kim
The present study was conducted to investigate the ginsenoside profiles of the main root, root hair, and leaf of ginseng in order to demonstrate their possible application in medicine. The total ginsenoside content of the leaf was up to 12 times than that in the main root, and the content of protopanaxadiol groups was higher than that of protopanaxatriol groups in all the samples. The leaf was shown to contain high amounts of ginsenosides Rb3 and Rh1, whereas the main root contained large amounts of ginsenosides Rb1 and Rc...
December 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28071886/boronlectin-polyelectrolyte-ensembles-as-artificial-tongue-design-construction-and-application-for-discriminative-sensing-of-complex-glycoconjugates-from-panax-ginseng
#2
Xiao-Tai Zhang, Shu Wang, Guo-Wen Xing
Ginsenoside is a large family of triterpenoid saponins from panax ginseng, which possesses various important biological functions. Due to the very similar structures of these complex glycoconjugates, it is crucial to develop powerful analytic method to identify ginsenosides qualitatively or quantitatively. We herein report an eight-channel fluorescent sensor array as artificial tongue to achieve the discriminative sensing of ginsenosides. The fluorescent cross-responsive array was constructed by four boronlectins bearing flexible boronic acid moieties (FBAs) with multiple reactive sites and two linear poly(phenylene-ethynylene) (PPEs)...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28067784/sailuotong-prevents-hydrogen-peroxide-h%C3%A2-o%C3%A2-induced-injury-in-ea-hy926-cells
#3
Sai Wang Seto, Dennis Chang, Wai Man Ko, Xian Zhou, Hosen Kiat, Alan Bensoussan, Simon M Y Lee, Maggie P M Hoi, Genevieve Z Steiner, Jianxun Liu
Sailuotong (SLT) is a standardised three-herb formulation consisting of Panax ginseng, Ginkgo biloba, and Crocus sativus designed for the management of vascular dementia. While the latest clinical trials have demonstrated beneficial effects of SLT in vascular dementia, the underlying cellular mechanisms have not been fully explored. The aim of this study was to assess the ability and mechanisms of SLT to act against hydrogen peroxide (H₂O₂)-induced oxidative damage in cultured human vascular endothelial cells (EAhy926)...
January 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28053615/antioxidant-and-hepatoprotective-effects-of-fermented-red-ginseng-against-high-fat-diet-induced-hyperlipidemia-in-rats
#4
Myeong-Hwan Kim, Eun-Jin Lee, Jeong-Mu Cheon, Ki-Jun Nam, Tae-Ho Oh, Kil-Soo Kim
This study was performed to investigate the antioxidant and hepatoprotective effects of fermented red ginseng (Panax ginseng C.A. Meyer; FRG) on high-fat diet-induced hyperlipidemia in rats. Sprague-Dawley rats were divided into four groups of seven: normal control, NC; high-fat diet control, HFC; high-fat diet-0.5% FRG, HF-FRGL; and high-fat diet-1% FRG, HF-FRGH. All rats were fed a high-fat diet for eight weeks, except those in the NC group, while rats in the FRG treatment groups received drinking water containing 0...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28040652/enhancing-saccharomyces-cerevisiae-reactive-oxygen-species-and-ethanol-stress-tolerance-for-high-level-production-of-protopanoxadiol
#5
Fanglong Zhao, Yanhui Du, Peng Bai, Jingjing Liu, Wenyu Lu, Yingjin Yuan
Protopanaxadiol (PPD) is an active compound in Panax ginseng. Recently, an optimized PPD synthesis pathway contained a ROS releasing step (a P450-type PPD synthase, PPDS) was introduced into Saccharomyces cerevisiae. Here reported a synergistic effect of PPDS-CPR (CPR, cytochrome P450 reductase) uncoupling and ethanol stress on ROS releasing, which reduced cells viability. To build a robust strain, a cell wall integrity associated gene SSD1 was high-expressed to improve ethanol tolerance, and ROS level decreased for 24...
March 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28039696/ginseng-and-cancer
#6
Ahmet Unlu, Erdinc Nayir, Onder Kirca, Hale Ay, Mustafa Ozdogan
Derived from the Greek word Panacea that means 'cure for all', Ginseng (Panax) has had an important place in Chinese Medicine for many of years. As the name suggests, it is believed to be a miraculous plant effective in the treatment of many health problems. It is claimed to have many effects such as sedative, hypnotic, aphrodisiac, antidepressant, diuretic, and stimulating effects, and to be effective in the treatment of certain health problems such as diabetes, Alzheimer's disease, erectile dysfunction and infections...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28038384/the-integration-of-gc-ms-and-lc-ms-to-assay-the-metabolomics-profiling-in-panax-ginseng-and-panax-quinquefolius-reveals-a-tissue-and-species-specific-connectivity-of-primary-metabolites-and-ginsenosides-accumulation
#7
Jia Liu, Yang Liu, Yu Wang, Ann Abozeid, Yuan-Gang Zu, Zhong-Hua Tang
The traditional medicine Ginseng mainly including Panax ginseng and Panax quinquefolius is the most widely consumed herbal product in the world. Despite the extensive investigation of biosynthetic pathway of the active compounds ginsenosides, our current understanding of the metabolic interlink between ginsenosides synthesis and primary metabolism at the whole-plant level. In this study, the tissue-specific profiling of primary and the secondary metabolites in two different species of ginseng were investigated by gas chromatography- and liquid chromatography coupled to mass spectrometry...
December 23, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28027838/extraction-isolation-and-aromatase-inhibitory-evaluation-of-low-polar-ginsenosides-from-panax-ginseng-leaves
#8
Yuchi Zhang, Jianxu Zhang, Chunming Liu, Min Yu, Sainan Li
A hyphenated accelerated solvent extraction (ASE) technique was elaborately coupled with centrifugal partition chromatography (CPC), ultra-high-performance liquid chromatography (UHPLC), and photo-diode array detector (PDA). This approach was applied to obtain low-polar ginsenoside fractions from the leaves of Panax ginseng. The CPC fractions were isolated and analyzed using the hyphenated technique, and followed by testing and evaluation of their aromatase inhibitory effects. Subsequently, the aromatase inhibition rates of the compositions in the CPC fractions were calculated using a multivariable linear regression model...
December 23, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28025886/comparative-analysis-of-the-rats-gut-microbiota-composition-in-animals-with-different-ginsenosides-metabolizing-activity
#9
Wei-Wei Dong, Fang-Ling Xuan, Fei-Liang Zhong, Jun Jiang, Songquan Wu, Donghao Li, Lin-Hu Quan
Following oral intake of Panax ginseng, major ginsenosides are metabolized to deglycosylated ginsenosides by gut microbiota before absorption into the blood. As the composition of gut microbiota varies between individuals, metabolic activities are significantly different. We selected 6 rats with low efficiency metabolism (LEM) and 6 rats with high efficiency metabolism (HEM) from 60 rats following oral administration of Panax ginseng extract, and analyzed their gut microbiota composition using Illumina HiSeq sequencing of the 16S rRNA gene...
January 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28017829/12-chloracetyl-ppd-a-novel-dammarane-derivative-shows-anti-cancer-activity-via-delay-the-progression-of-cell-cycle-g2-m-phase-and-reactive-oxygen-species-mediate-cell-apoptosis
#10
Xu De Wang, Yuan Yuan Sun, Chen Zhao, Fan Zhi Qu, Yu Qing Zhao
(20R)-Dammarane-3β, 12β, 20, 25-tetrol (25-OH-PPD) is a ginsenoside isolated from Panax ginseng (C. A. Meyer). This compound exhibits anti-cancer activities on many human cancer cell lines. In this study, we investigated anti-cancer mechanisms of 12β-O-(L-Chloracetyl)-dammar-20(22)-ene-3β,25-diol(12-Chloracetyl-PPD), a modified 25-OH-PPD. We found that compound 12-Chloracetyl-PPD resulted in a concentration-dependent inhibition of viability in prostate, breast, and gastric cancer cells, without affecting the viability of normal cell (human gastric epithelial cell line-GES-1, hair follicle dermal papilla cell line-HHDPC and rat myocardial cell line-H9C2)...
December 23, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28012988/the-host-immune-enhancing-agent-korean-red-ginseng-oil-successfully-attenuates-brucella-abortus-infection-in-a-murine-model
#11
Alisha Wehdnesday Bernardo Reyes, Huynh Tan Hop, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Soo Jong Park, Kwang Dong Kim, WonGi Min, Hu Jang Lee, Man Hee Rhee, Yi-Seong Kwak, Suk Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Panax ginseng Meyer (Araliaceae), is one of the most valuable traditional Chinese medicines and is used for the treatment of various human diseases. In this study, we elucidated the protective mechanism of the essential oil from Korean red ginseng (RGO) against Brucella infection. MATERIALS AND METHODS: The effects of RGO on Brucella abortus viability, NO production, uptake and intracellular growth in macrophages were investigated...
December 21, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28010843/an-in-source-multiple-collision-neutral-loss-filtering-based-nontargeted-metabolomics-approach-for-the-comprehensive-analysis-of-malonyl-ginsenosides-from-panax-ginseng-p-%C3%A2-quinquefolius-and-p-%C3%A2-notoginseng
#12
Xiao-Jian Shi, Wen-Zhi Yang, Shi Qiu, Chang-Liang Yao, Yao Shen, Hui-Qin Pan, Qi-Rui Bi, Min Yang, Wan-Ying Wu, De-An Guo
The simultaneous identification and quantification of target metabolites from herbal medicines are difficult to implement by the full-scan MS based nontargeted metabolomics approaches. Here an in-source multiple collision-neutral loss filtering (IMC-NLF) based nontargeted metabolomics approach is developed and applied to identify and quantify the variations of malonyl-ginsenosides, a common group of acyl saponins with potential anti-diabetic activity, among Panax ginseng, P. quinquefolius, and P. notoginseng...
February 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28008248/coalescence-of-functional-gold-and-monodisperse-silver-nanoparticles-mediated-by-black-panax-ginseng-meyer-root-extract
#13
Dandan Wang, Josua Markus, Yeon-Ju Kim, Chao Wang, Zuly Elizabeth Jiménez Pérez, Sungeun Ahn, Verónica Castro Aceituno, Ramya Mathiyalagan, Deok Chun Yang
A rapid biological synthesis of multifunctional gold nanoparticle (AuNp) and monodisperse silver nanoparticle (AgNp) was achieved by an aqueous extract of black Panax ginseng Meyer root. The physicochemical transformation into black ginseng (BG) greatly enhanced the pharmacological activities of white ginseng and its minor ginsenoside content. The optimal temperature conditions and kinetics of bioreduction were investigated. Formation of BG-AuNps and BG-AgNps was verified by ultraviolet-visible spectrophotometry at 548 and 412 nm, respectively...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27991533/distinct-urine-metabolome-after-asian-ginseng-and-american-ginseng-intervention-based-on-gc-ms-metabolomics-approach
#14
Liu Yang, Qing-Tao Yu, Ya-Zhong Ge, Wen-Song Zhang, Yong Fan, Chung-Wah Ma, Qun Liu, Lian-Wen Qi
Ginseng occupies a prominent position in the list of best-selling natural products worldwide. Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius) show different properties and medicinal applications in pharmacology, even though the main active constituents of them are both thought to be ginsenosides. Metabolomics is a promising method to profile entire endogenous metabolites and monitor their fluctuations related to exogenous stimulus. Herein, an untargeted metabolomics approach was applied to study the overall urine metabolic differences between Asian ginseng and American ginseng in mice...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27983571/anti-fatigue-effects-of-small-molecule-oligopeptides-isolated-from-panax-ginseng-c-a-meyer-in-mice
#15
Lei Bao, Xiaxia Cai, Junbo Wang, Yuan Zhang, Bin Sun, Yong Li
Panax ginseng C. A. Meyer (ginseng) is an edible and medicinal Chinese herb, which is often used in Asian countries for physical fitness. Ginseng is reported to have a wide range of biological activity and pharmaceutical properties. There were more studies on ginsenosides and polysaccharides, but fewer studies on ginseng oligopeptides (GOP), which are small molecule oligopeptides isolated from ginseng. The present study was designed to evaluate the anti-fatigue effects of GOP in mice and explore the possible underlying mechanism...
December 13, 2016: Nutrients
https://www.readbyqxmd.com/read/27982079/ginsenoside-rg1-attenuates-ultraviolet-b-induced-glucocortisides-resistance-in-keratinocytes-via-nrf2-hdac2-signalling
#16
Jun Li, Dong Liu, Jinfeng Wu, Daniel Zhang, Binbin Cheng, Yani Zhang, Zifei Yin, Yuan Wang, Juan Du, Changquan Ling
Oxidative stress, which occurs after ultraviolet (UV) radiation, usually results in Glucocorticoid (GC) resistance and the subsequent development of skin inflammation. One approach to protecting the skin against UV radiation is the use of antioxidants. The ginsenoside Rg1 is a novel natural antioxidant isolated from the medicinal plant Panax ginseng C.A. Mey. We demonstrated that UVB exposure exacerbated inflammation and reduced both the level of the glucocorticoid receptor (GR) and the efficacy of dexamethasone (Dex) in human keratinocytes (HaCaT cells)...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27981642/ginseng-protein-reverses-amyloid-beta-peptide-and-h2-o2-cytotoxicity-in-neurons-and-ameliorates-cognitive-impairment-in-ad-rats-induced-by-a-combination-of-d-galactose-and-alcl3
#17
Hongyan Li, Jie Song, Jianghua Zhang, Tianmin Wang, Yuhui Yan, Zhenyu Tao, Shaoheng Li, Hui Zhang, Tingguo Kang, Jingxian Yang
Ginseng (Panax ginseng C.A. Meyer) is one of the most widely used herbal medicines worldwide. The present study evaluated the neuroprotective effects of ginseng protein (GP) and its possible mechanisms in a cellular and animal model of AD. The results demonstrated that GP (10-100 µg/mL) significantly improved the survival rate of neurons and reduced the cells' apoptosis and the mRNA expression of caspase-3 and Bax/Bcl-2. In addition, GP (0.1 g/kg) significantly shortened the escape latency, prolonged the crossing times and the percentage of residence time; reduced the level of Aβ1-42 and p-tau, the activity of T-NOS and iNOS, and the content of MDA and NO, improved the activity of SOD, the concentration of cAMP and the protein expression of p-PKA/PKA and -CREB/CREB...
December 16, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27976207/comparison-of-quality-and-ginsenoside-contents-in-roots-of-panax-ginseng-at-various-ages-in-gangwon-korea
#18
H N Jeong, K J Lee, J S Jeong, Y M Mo, S J Lee, S I Kim
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975618/comparison-of-growth-characteristics-and-quality-of-korean-ginseng-panax-ginseng-c-a-meyer-using-different-shade-materials
#19
H H Kim, B J Seong, K S Lee, S I Kim, J M Geun, J W Cho
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975541/growth-characteristics-and-ginsenoside-contents-of-korean-ginseng-panax-ginseng-c-a-meyer-by-shade-materials-and-green-manure-crops
#20
B J Seong, H H Kim, K S Lee, S I Kim, J M Geun, J W Cho
No abstract text is available yet for this article.
December 2016: Planta Medica
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