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Panax ginseng

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https://www.readbyqxmd.com/read/27912940/panax-ginseng-and-salvia-miltiorrhiza-supplementation-during-eccentric-resistance-training-in-middle-aged-and-older-adults-a-double-blind-randomized-control-trial
#1
Hsin-Fu Lin, Chun-Chung Chou, Hsiao-Han Chao, Hirofumi Tanaka
BACKGROUND: Muscle damage induced by an acute bout of eccentric exercise results in transient arterial stiffening. In this study, we sought to determine the effects of progressive eccentric resistance exercise training on vascular functions, and whether herb supplementation would enhance training adaptation by ameliorating the arterial stiffening effects. METHODS: By using a double-blinded randomized placebo-controlled design, older adults were randomly assigned to either the Panax ginseng and Salvia miltiorrhiza supplementation group (N=12) or the placebo group (N=11)...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27910952/protective-effects-of-ginsenoside-rg1-on-intestinal-ischemia-reperfusion-injury-induced-oxidative-stress-and-apoptosis-via-activation-of-the-wnt-%C3%AE-catenin-pathway
#2
Guo Zu, Jing Guo, Ningwei Che, Tingting Zhou, Xiangwen Zhang
Ginsenoside Rg1 (Rg1) is one of the major bioactive ingredients in Panax ginseng, and it attenuates inflammation and apoptosis. The aims of our study were to explore the potential of Rg1 for the treatment of intestinal I/R injury and to determine whether the protective effects of Rg1 were exerted through the Wnt/β-catenin signaling pathway. In this study, Rg1 treatment ameliorated inflammatory factors, ROS and apoptosis that were induced by intestinal I/R injury. Cell viability was increased and cell apoptosis was decreased with Rg1 pretreatment following hypoxia/reoxygenation (H/R) in the in vitro study...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27899249/ginsenoside-20-s-rg3-induced-autophagy-to-inhibit-migration-and-invasion-of-ovarian-cancer
#3
Xia Zheng, Wei Chen, Huilian Hou, Jie Li, Huijin Li, Xiaomin Sun, Le Zhao, Xu Li
BACKGROUND: Autophagy maintains cellular homeostasis through engulfing cytoplasmic proteins and organelles, and plays an important role in cancer initiation and progression. Ginsenoside 20(S)-Rg3, an active ingredient of Panax ginseng, exerts anti-cancer functions in various cancers. However, its molecular mechanisms, including its effect on autophagy, are not fully elucidated in tumor models. METHODS: Ovarian cancer cell line SKOV3 was treated by various concentrations of 20(S)-Rg3...
November 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27893436/carbon-nanotubes-as-carriers-of-panax-ginseng-metabolites-and-enhancers-of-ginsenosides-rb1-and-rg1-anti-cancer-activity
#4
Mohamed H Lahiani, Souzan Eassa, Charlette Parnell, Zeid Nima, Anindya Ghosh, Alexandru S Biris, Mariya V Khodakovskaya
A major benefit to nanomaterial based-medicine is the ability to provide nanosized vehicles for sporadic metabolites. Here, we describe how the conjugation of valuable ginseng secondary metabolites (ginsenoside Rb1 or Rg1) with carbon nanotubes (CNT) can enhance their anti-proliferative and anti-cancer effects. Ginsenoside-CNT conjugate (Rb-CNT or Rg-CNT) permitted the ginsenosides to be used at a low dose, yet achieve a higher incidence of cancer killing. We were able to demonstrate that the ginsenoside-CNT conjugate can decrease cell viability up to 62% in breast cancer cells (MCF-7) and enhance antiproliferation of drug-resistant pancreatic cancer cells (PANC-1) by 61%...
November 28, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27864798/pharmacokinetic-drug-interactions-with-panax-ginseng
#5
REVIEW
Meenakshi R Ramanathan, Scott R Penzak
Panax ginseng is widely used as an adaptogen throughout the world. The major active constituents of P. ginseng are ginsenosides. Most naturally occurring ginsenosides are deglycosylated by colonic bacteria to intestinal metabolites. Ginsenosides along with these metabolites are widely accepted as being responsible for the pharmacologic activity and drug interaction potential of ginseng. Numerous preclinical studies have assessed the influence of various ginseng components on cytochrome P450 (CYP), glucuronidation, and drug transport activity...
November 18, 2016: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27863345/suppression-of-tnf-%C3%AE-and-free-radicals-reduces-systematic-inflammatory-and-metabolic-disorders-radioprotective-effects-of-ginseng-oligopeptides-on-intestinal-barrier-function-and-antioxidant-defense
#6
Li-Xia He, Jun-Bo Wang, Bin Sun, Jian Zhao, Lin Li, Teng Xu, Hui Li, Jing-Qin Sun, Jinwei Ren, Rui Liu, Qi-He Chen, Zhao-Feng Zhang, Yong Li
Irradiation therapy is markedly associated with intestinal injure and oxidant stress. This study aimed to investigate the effects of ginseng (Panax ginseng C.A. Mey.) oligopeptides (GOP) on irradiation-induced intestinal injury and antioxidant defense in mice. BALB/c mice (8 weeks old) were randomly divided into six groups: vehicle control, irradiation control (IR), IR+whey protein [0.30 g/kg body weight (BW)], IR+GOP 0.15 g/kg BW, IR+GOP 0.30 g/kg BW and IR+GOP 0.60 g/kg BW. Postirradiation 30-day survival trial, white blood cells count and bone marrow hematopoietic system damage were performed to identify the injury degree induced by irradiation...
October 26, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27860473/use-of-plant-extracts-as-an-efficient-alternative-therapy-of-respiratory-tract-infections
#7
Karel Šmejkal, Veronika Rjašková
Medicinal plants are advantageously used in the treatment of respiratory tract diseases. Upper respiratory tract catarrh is one of the diseases associated with seasonal weakening of immunity, and therefore, plant drugs with a non-specific immunomodulation effect are often used. Such plants include, but are not limited to, Echinacea (Echinacea purpurea) and American ginseng (Panax quinquefolius). In combination with medicinal plants having antibacterial and antiseptic effects, such as thyme (Thymus vulgaris) and pelargonium (Pelargonium sidoides), they can constitute efficient help in the treatment of respiratory tract diseases, shorten the duration of the disease and reduce the need of antibiotic therapy...
2016: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/27855495/pharmacological-importance-characterization-and-applications-of-gold-and-silver-nanoparticles-synthesized-by-panax-ginseng-fresh-leaves
#8
Priyanka Singh, Hina Singh, Sungeun Ahn, Verónica Castro-Aceituno, Zuly Jiménez, Shakina Yesmin Simu, Yeon Ju Kim, Deok Chun Yang
Previously, we showed the rapid and eco-friendly synthesis of gold and silver nanoparticles within 3 and 45 min by fresh leaves extract of herbal medicinal plant Panax ginseng. In addition, we characterized the nanoparticles in terms of shape, size, morphology and stability by FE-TEM, EDX, elemental mapping, SEAD, XRD and particles size analysis. In addition of this, we showed their antimicrobial, anti-coagulant, and biofilm inhibition activity of nanoparticles. Continuing our previous study, here we highlight the further characterization and biomedical applications of P...
November 18, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27843725/development-of-highly-transferable-microsatellites-for-panax-ginseng-araliaceae-using-whole-genome-data
#9
Peng Jiang, Feng-Xue Shi, Ya-Ling Li, Bao Liu, Lin-Feng Li
PREMISE OF THE STUDY: Highly transferable expressed sequence tag (EST) microsatellites were developed for Panax ginseng (Araliaceae), one of the most celebrated traditional Chinese medicines and an endangered species in East Asia, using whole-genome data. METHODS AND RESULTS: Twenty-one EST microsatellites were characterized from next-generation sequencing and were composed of di- and trinucleotide repeats. Polymorphisms and genetic diversity were evaluated for 45 accessions of three ginseng landraces...
November 2016: Applications in Plant Sciences
https://www.readbyqxmd.com/read/27837549/purification-and-characterization-of-a-novel-ginsenoside-rc-hydrolyzing-%C3%AE-glucosidase-from-armillaria-mellea-mycelia
#10
Jitendra Upadhyaya, Min-Sun Yoon, Min-Ji Kim, Nam-Soo Ryu, Young-Eun Song, Young-Hoi Kim, Myung-Kon Kim
Ginsenosides are the principal compounds responsible for the pharmacological effects and health benefits of Panax ginseng root. Among protopanaxadiol (PPD)-type ginsenosides, minor ginsenosides such as ginsenoside (G)-F2, G-Rh2, compound (C)-Mc1, C-Mc, C-O, C-Y, and C-K are known to be more pharmacologically active constituents than major ginsenosides such as G-Rb1, G-Rb2, G-Rc, and G-Rd. A novel ginsenoside Rc-hydrolyzing β-glucosidase (BG-1) from Armillaria mellea mycelia was purified as a single protein band with molecular weight of 121...
December 2016: AMB Express
https://www.readbyqxmd.com/read/27831475/pglox6-encoding-a-lipoxygenase-contributes-to-jasmonic-acid-biosynthesis-and-ginsenoside-production-in-panax-ginseng
#11
Shadi Rahimi, Yu-Jin Kim, Johan Sukweenadhi, Dabing Zhang, Deok-Chun Yang
No abstract text is available yet for this article.
November 9, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27828760/ginseng-stem-and-leaf-saponins-gsls-enhanced-protective-immune-responses-induced-by-toxoplasma-gondii-heat-shocked-protein-70-hsp70-against-toxoplasmosis-in-mice
#12
Xunhui Zhuo, Hongchao Sun, Suhua Wang, Xiaolu Guo, Haojie Ding, Yi Yang, Ying Shan, Aifang Du
Toxoplasma gondii is an obligate intracellular protozoan parasite and is able to infect birds and mammals including humans. In order to find effective antigen-adjuvant combinations that can boost the immunogenicity and protection of antigen vaccines against toxoplasmosis, we examined the protective efficacy in mice immunized with recombinant protein HSP70 when co-administered with ginseng stem-and-leaf saponins (GSLS) isolated from Panax ginseng. All immunized mice produced significantly high levels of specific antibodies against rTgHSP70 and splenocytes from mice presented strong proliferative immune responses...
November 9, 2016: Journal of Parasitology
https://www.readbyqxmd.com/read/27818924/identification-and-differentiation-of-panax-ginseng-panax-quinquefolium-and-panax-notoginseng-by-monitoring-multiple-diagnostic-chemical-markers
#13
Wenzhi Yang, Xue Qiao, Kai Li, Jingran Fan, Tao Bo, De-An Guo, Min Ye
To differentiate traditional Chinese medicines (TCM) derived from congeneric species in TCM compound preparations is usually challenging. The roots of Panax ginseng (PG), Panax quinquefolium (PQ) and Panax notoginseng (PN) are used as popular TCM. They contain similar triterpenoid saponins (ginsenosides) as the major bioactive constituents. Thus far, only a few chemical markers have been discovered to differentiate these three species. Herein we present a multiple marker detection approach to effectively differentiate the three Panax species, and to identify them in compound preparations...
November 2016: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/27816645/stereospecificity-of-ginsenoside-rg2-epimers-in-the-protective-response-against-uv-b-radiation-induced-oxidative-stress-in-human-epidermal-keratinocytes
#14
Hyun-Ji Kang, Yu-Hua Huang, Hye-Won Lim, Daehyun Shin, Kyounghee Jang, Yoonjin Lee, Kyunghoon Kim, Chang-Jin Lim
Ginseng, referring to the dried roots of Panax ginseng C.A. Meyer, has been known as a famous traditional folkloric medicine in East Asian countries for a long time. In recent years, it has been gaining a worldwide popularity as a dietary herbal supplement. Ginsenosides are bioactive ingredients that are responsible for most pharmacological efficacies of ginseng. Ginsenoside Rg2 (Rg2), one of minor protopanaxatriol (PPT)-type ginsenosides, exists in two epimeric forms, 20(S)-ginsenoside Rg2 [20(S)-Rg2] and 20(R)-ginsenoside Rg2 [20(R)-Rg2]...
October 29, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27811076/pglox6-encoding-a-lipoxygenase-contributes-to-jasmonic-acid-biosynthesis-and-ginsenoside-production-in-panax-ginseng
#15
Shadi Rahimi, Yu-Jin Kim, Johan Sukweenadhi, Dabing Zhang, Deok-Chun Yang
Ginsenosides, the valuable pharmaceutical compounds in Panax ginseng, are triterpene saponins that occur mainly in ginseng plants. It was shown that in vitro treatment with the phytohormone jasmonic acid (JA) is able to increase ginsenoside production in ginseng plants. To understand the molecular link between JA biosynthesis and ginsenoside biosynthesis, we identified a JA biosynthetic 13-lipoxygenase gene (PgLOX6) in P. ginseng that promotes ginsenoside production. The expression of PgLOX6 was high in vascular bundles, which corresponds with expression of ginsenoside biosynthetic genes...
November 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27798744/pedobacter-panacis-sp-nov-isolated-from-panax-ginseng-soil
#16
Priyanka Singh, Hina Singh, Yeon-Ju Kim, Deok-Chun Yang
A novel strain, DCY108(T) was isolated from soil of a Panax ginseng field, Yeoncheon province (38°04'N 126°57'E), Republic of Korea. Strain DCY108(T) is Gram-negative, non-motile, non-flagellate, rod-shaped, and aerobic. The bacterium grows optimally at 25-30 °C, pH 6.5-7.0 and 1 % NaCl. Phylogenetically, strain DCY108(T) is closely related to Pedobacter jejuensis JCM 18824(T), Pedobacter aquatilis JCM 13454(T), Pedobacter kyungheensis LMG 26577(T) and the type strain of the genus Pedobacter heparinus DSM 2366(T)...
October 31, 2016: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/27797280/north-american-ginseng-panax-quinquefolius-suppresses-%C3%AE-adrenergic-dependent-signalling-hypertrophy-and-cardiac-dysfunction
#17
Xilan Tang, Xiaohong Tracey Gan, Venkatesh Rajapurohitam, Cathy Xiaoling Huang, Jenny Xue, Edmund M K Lui, Morris Karmazyn
There is increasing evidence for a beneficial effect of ginseng on cardiac pathology. Here, we determined whether North American ginseng can modulate the deleterious effects of the β-adrenoceptor agonist isoproterenol on cardiac hypertrophy and function using in vitro and in vivo approaches. Isoproterenol was administered for 2 weeks at either 25 mg/kg per day or 50 mg/kg per day (ISO25 or ISO50) via a subcutaneously implanted osmotic mini-pump to either control rats or those receiving ginseng (0.9 g/L in the drinking water ad libitum)...
December 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27795912/profiling-of-ginsenosides-in-the-two-medicinal-panax-herbs-based-on-ultra-performance-liquid-chromatography-electrospray-ionization-mass-spectrometry
#18
Jia Liu, Yang Liu, Long Zhao, Zhong-Hua Zhang, Zhong-Hua Tang
As the king of herb plants, ginseng has been used for nearly 5000 years in medicines in Asia and recently in the West. Ginsenosides, the main active constituents in Panax herbs, have prominent immunoregulatory effects. Although extensively studied in the roots, ginsenosides have not been studied with regard to their profiles and natural variations in the leaf, stem, petiole, lateral root, and main roots during development or among species. In this study, a sensitive ultra-performance liquid chromatography-electrospray ionization-mass spectrometry method with a shorter chromatographic running time was developed and validated for simultaneous quantification of ten ginsenosides...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27790730/development-and-validation-of-an-uplc-q-tof-ms-assay-for-the-quantitation-of-neopanaxadiol-in-beagle-dog-plasma-application-to-a-pharmacokinetic-study
#19
Cong Geng, Chun-Hong Wang, Hong Hu, Xiao-Ping Gao, Ai-Hua Gong, Ying-Wei Lin, Xiu-Shuang Fan, Heng Li, Jian-Yuan Yin
Neopanaxadiol (NPD), the main panaxadiol constituents of Panax ginseng C. A. Meyer (Araliaceae), has been regarded as the active component for the treatment of Alzheimer's disease. However, few references are available about pharmacokinetic evaluation for NPD. Accordingly, a rapid and sensitive method for quantitative analysis of NPD in beagle dog plasma based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry was developed and validated. Analytes were extracted from plasma by liquid-liquid extraction and chromatographic separation was achieved on an Agilent Zorbax Stable Bond C18 column...
October 27, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27776327/component-analysis-and-target-cell-based-neuroactivity-screening-of-panax-ginseng-by-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#20
Jinbin Yuan, Yang Chen, Jian Liang, Chong-Zhi Wang, Xiaofei Liu, Zhihong Yan, Yi Tang, Jiankang Li, Chun-Su Yuan
Ginseng is one of the most widely used natural medicines in the world. Recent studies have suggested Panax ginseng has a wide range of beneficial effects on aging, central nervous system disorders, and neurodegenerative diseases. However, knowledge about the specific bioactive components of ginseng is still limited. This work aimed to screen for the bioactive components in Panax ginseng that act against neurodegenerative diseases, using the target cell-based bioactivity screening method. Firstly, component analysis of Panax ginseng extracts was performed by UPLC-QTOF-MS, and a total of 54 compounds in white ginseng were characterized and identified according to the retention behaviors, accurate MW, MS characteristics, parent nucleus, aglycones, side chains, and literature data...
December 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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