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Panax ginseng

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https://www.readbyqxmd.com/read/28430162/ameliorative-effects-and-possible-molecular-mechanism-of-action-of-black-ginseng-panax-ginseng-on-acetaminophen-mediated-liver-injury
#1
Jun-Nan Hu, Zhi Liu, Zi Wang, Xin-Dian Li, Lian-Xue Zhang, Wei Li, Ying-Ping Wang
Background: Frequent overdosing of acetaminophen (APAP) has become the major cause of acute liver injury (ALI). The present study aimed to evaluate the potential hepatoprotective effects of black ginseng (BG) on APAP-induced mice liver injuries and the underlying mechanisms of action were further investigated for the first time. Methods: Mice were treated with BG (300, 600 mg/kg) by oral gavage once a day for seven days. On the 7th day, all mice were treated with 250 mg/kg APAP which caused severe liver injury after 24 h and hepatotoxicity was assessed...
April 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28428445/pectinase-treated-panax-ginseng-protects-heat-stress-induced-testicular-damage-in-rats
#2
Min Kyoung Kim, Kyu-Min Cha, Seock-Yeon Hwang, Un-Kyu Park, Seok Kyo Seo, Sang-Ho Lee, Min-Sik Jeong, SiHyun Cho, Spandana Rajendra Kopalli, Si-Kwan Kim
Testicular hyperthermia is well studied to cause impaired spermatogenesis. In the present study, the protective effect of enzymatically modified (pectinase-treated) Panax ginseng (GINST) against intermittent sub-chronic heat stress-induced testicular damage in rats was investigated. Male Sprague-Dawley rats were divided into four groups: normal control (NC), heat-stressed control (HC), heat-stressed plus GINST-100 mg/kg/day (HG100) and heat-stressed plus GINST-200 mg/kg/day (HG200) treatment groups. GINST (100 and 200 mg/kg/day) was mixed separately with a regular pellet diet and was administered orally for 8 weeks starting from 1 week before heat exposure...
June 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28427912/hepataprotective-effects-of-ginsenoside-rg1-a-review
#3
REVIEW
Yan Gao, Shifeng Chu, Zhao Zhang, Naihong Chen
BACKGROUND AND ETHNOPHARMACOLOGICAL RELEVANCE: Ginseng has been used as efficient tonic and for the treatment of various diseases including hepatic disorders. Ginseng saponins, also known as ginsenosides, are principal constituents and have been treated to be responsible for disparate ginseng health benefits. The current review mainly focuses on ginsenoside Rg1, a compound isolated from traditional Chinese herbal medicine Panax ginseng Meyer. AIMS: To summary the hepataprotective effects and related mechanisms of ginsenoside Rg1, we conclude this review by combining the literature and our own researches...
April 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28421197/ginsenoside-rg1-ameliorates-cigarette-smoke-induced-airway-fibrosis-by-suppressing-the-tgf-%C3%AE-1-smad-pathway-in-vivo-and-in-vitro
#4
Sibin Guan, Qian Liu, Fengfeng Han, Wen Gu, Lin Song, Yue Zhang, Xuejun Guo, Weiguo Xu
Small airway fibrosis is a key pathological process accompanying chronic obstructive pulmonary disease (COPD) and includes fibroblast/myofibroblast transdifferentiation and excessive extracellular matrix deposition. Ginsenoside Rg1, one of the main active ingredients of Panax ginseng, has been shown to exert an antifibrotic effect in many tissues. However, little is known about the underlying mechanism and whether ginsenoside Rg1 can exert an effect on small airway fibrosis. We investigated the anti-small airway fibrosis effects of ginsenoside Rg1 in human embryonic lung fibroblasts and in COPD rats...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28417089/demographic-and-medication-characteristics-of-traditional-chinese-medicine-users-among-colorectal-cancer-survivors-a-nationwide-database-study-in-taiwan
#5
Chien-Tung Wu, Yueh-Ting Tsai, Jung-Nien Lai
Chinese herbal product (CHP) is the major type of traditional Chinese medicine (TCM) and widely used to relief the symptom of colorectal cancer. The aim of the study was to analyze the utilization of CHP for treating patients with colorectal cancer in Taiwan. The usage of CHP, frequency of services, and prescription pattern for colorectal cancer were analyzed from a randomly sampled cohort of 1 million beneficiaries from the National Health Insurance Research Database. The odds ratios for utilization of CHP were estimated with logistic regression model...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28413329/protective-effect-of-ginsenoside-rh3-against-anticancer-drug-induced-apoptosis-in-llc-pk1-kidney-cells
#6
Hye Lim Lee, Ki Sung Kang
BACKGROUND: Ginsenosides are active components of Panax ginseng that exert various health benefits including kidney protection effect. The medicinal activity of ginsenosides can be enhanced by modulating their stereospecificity by heat processing. Ginsenosides Rk2 and Rh3 represent positional isomers of the double bond at C-20(21) or C-20(22). METHODS: The present study investigated the kidney-protective effects of ginsenosides Rk2 and Rh3 against cisplatin, a platinum based anticancer drug, induced apoptotic damage in renal proximal LLC-PK1 cells...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28413328/effect-of-korean-red-ginseng-intake-on-the-survival-duration-of-human-immunodeficiency-virus-type-1-patients
#7
Young-Keol Cho, Jung-Eun Kim
BACKGROUND: Long-term ginseng intake can increase longevity in healthy individuals. Here, we examined if long-term treatment with Panax ginseng Meyer (Korean Red Ginseng, KRG) can also enhance survival duration (SD) in patients with human immunodeficiency virus type 1 (HIV-1) infection. METHODS: We retrospectively analyzed 252 HIV-1 patients diagnosed from 1986 to 2013 prior to the initiation of antiretroviral therapy. Overall, 162 patients were treated with KRG (3,947 ± 4,943 g) for 86 ± 63 mo...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28413325/the-psychopharmacological-activities-of-vietnamese-ginseng-in-mice-characterization-of-its-psychomotor-sedative-hypnotic-antistress-anxiolytic-and-cognitive-effects
#8
Irene Joy I Dela Peña, Hee Jin Kim, Chrislean Jun Botanas, June Bryan de la Peña, Thi Hong Van Le, Minh Duc Nguyen, Jeong Hill Park, Jae Hoon Cheong
BACKGROUND: Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered ginseng species. Studies on its chemical constituents have shown that VG is remarkably rich in ginseng saponins, particularly ocotillol saponins. However, the psychopharmacological effects of VG have not been characterized. Thus, in the present study we screened the psychopharmacological activities of VG in mice. METHODS: VG extract (VGE) was orally administered to mice at various dosages to evaluate its psychomotor (open-field and rota-rod tests), sedative-hypnotic (pentobarbital-induced sleeping test), antistress (cold swimming test), anxiolytic (elevated plus-maze test), and cognitive (Y-maze and passive-avoidance tests) effects...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28413322/improved-antimicrobial-effect-of-ginseng-extract-by-heat-transformation
#9
Peng Xue, Yang Yao, Xiu-Shi Yang, Jia Feng, Gui-Xing Ren
BACKGROUND: The incidence of halitosis has a prevalence of 22-50% throughout the world and is generally caused by anaerobic oral microorganisms, such as Fusobacterium nucleatum, Clostridium perfringens, and Porphyromonas gingivalis. Previous investigations on the structure-activity relationships of ginsenosides have led to contrasting results. Particularly, the antibacterial activity of less polar ginsenosides against halitosis-related bacteria has not been reported. METHODS: Crude saponins extracted from the Panax quinquefolius leaf-stem (AGS) were treated at 130°C for 3 h to obtain heat-transformed saponins (HTS)...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28413321/the-beneficial-effect-of-ginsenosides-extracted-by-pulsed-electric-field-against-hydrogen-peroxide-induced-oxidative-stress-in-hek-293-cells
#10
Di Liu, Ting Zhang, Zhifei Chen, Ying Wang, Shuang Ma, Jiyun Liu, Jingbo Liu
BACKGROUND: Ginsenosides are the main pharmacological components of Panax ginseng root, which are thought to be primarily responsible for the suppressing effect on oxidative stress. METHODS: 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and oxygen radical absorption capacity were applied to evaluate the antioxidant activities of the ginsenosides. Human embryonic kidney 293 (HEK-293) cells were incubated with ginsenosides extracted by pulsed electric field (PEF) and solvent cold soak extraction (SCSE) for 24 h and then the injury was induced by 40μM H2O2...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28413320/panax-ginseng-meyer-prevents-radiation-induced-liver-injury-via-modulation-of-oxidative-stress-and-apoptosis
#11
Hyeong-Geug Kim, Seong-Soon Jang, Jin-Seok Lee, Hyo-Seon Kim, Chang-Gue Son
BACKGROUND: Radiotherapy is one of the most important modalities in cancer treatment; however, normal tissue damage is a serious concern. Drug development for the protection or reduction of normal tissue damage is therefore a clinical issue. Herein, we evaluated the protective properties of Panax ginseng Meyer and its corresponding mechanisms. METHODS: C56BL/6 mice were orally pretreated with P. ginseng water extract (PGE; 25 mg/kg, 50 mg/kg, or 100 mg/kg) or intraperitoneally injected melatonin (20 mg/kg) for 4 d consecutively, then exposed to 15-Gy X-ray radiation 1 h after the last administration...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28413317/korean-red-ginseng-improves-atopic-dermatitis-like-skin-lesions-by-suppressing-expression-of-proinflammatory-cytokines-and-chemokines-in%C3%A2-vivo-and-in%C3%A2-vitro
#12
Ji-Ye Kee, Yong-Deok Jeon, Dae-Seung Kim, Yo-Han Han, Jinbong Park, Dong-Hyun Youn, Su-Jin Kim, Kwang Seok Ahn, Jae-Young Um, Seung-Heon Hong
BACKGROUND: The prevalence of allergic inflammatory diseases such as atopic dermatitis (AD), asthma, and allergic rhinitis worldwide has increased and complete recovery is difficult. Korean Red Ginseng, which is the heat-processed root of Panax ginseng Meyer, is widely and frequently used as a traditional medicine in East Asia. In this study, we investigated whether Korean Red Ginseng water extract (RGE) regulates the expression of proinflammatory cytokines and chemokines via the mitogen-activated protein kinases (MAPKs)/nuclear factor kappa B (NF-κB) pathway in allergic inflammation...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28413316/ginsenoside-rc-from-panax-ginseng-exerts-anti-inflammatory-activity-by-targeting-tank-binding-kinase-1-interferon-regulatory-factor-3-and-p38-atf-2
#13
Tao Yu, Yanyan Yang, Yi-Seong Kwak, Gwan Gyu Song, Mi-Yeon Kim, Man Hee Rhee, Jae Youl Cho
BACKGROUND: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects. METHODS: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-α/interferon-γ-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28413314/implications-of-red-panax-ginseng-in-oxidative-stress-associated-chronic-diseases
#14
REVIEW
Yoon-Mi Lee, Haelim Yoon, Hyun-Min Park, Byeng Chun Song, Kyung-Jin Yeum
The steaming process of Panax ginseng has been reported to increase its major known bioactive components, ginsenosides, and, therefore, its biological properties as compared to regular Panax ginseng. Biological functions of red Panax ginseng attenuating pro-oxidant environments associated with chronic diseases are of particular interest, since oxidative stress can be a key contributor to the pathogenesis of chronic diseases. Additionally, proper utilization of various biomarkers for evaluating antioxidant activities in natural products, such as ginseng, can also be important to providing validity to their activities...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28412215/involvement-of-serotonergic-noradrenergic-and-dopaminergic-systems-in-the-antidepressant-like-effect-of-ginsenoside-rb1-a-major-active-ingredient-of-panax-ginseng-c-a-meyer
#15
Guo-Li Wang, Zhong-Mei He, Hong-Yan Zhu, Yu-Gang Gao, Yan Zhao, He Yang, Liangxue Zhang
ETHNOPHARMACOLOGY RELEVANCE: Ginsenoside Rb1, a 20 (S)-protopanaxadiol, is a major active ingredient of Panax ginseng C.A. Meyer, which as the King of Chinese herbs, has been wildly used for the treatment of central nervous system diseases. Previous studies have shown that 20 (S)-protopanaxadiol possesses a novel antidepressant-like effect in the treatment of depression, whereas ginsenoside Rb1 in depression has been rarely reported. AIM OF THE REVIEW: The present study was to investigate the antidepressant-like effect of ginsenoside Rb1 and its relevant mechanisms...
April 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28411325/a-literature-update-elucidating-production-of-panax-ginsenosides-with-a-special-focus-on-strategies-enriching-the-anti-neoplastic-minor-ginsenosides-in-ginseng-preparations
#16
REVIEW
Tanya Biswas, A K Mathur, Archana Mathur
Ginseng, an oriental gift to the world of healthcare and preventive medicine, is among the top ten medicinal herbs globally. The constitutive triterpene saponins, ginsenosides, or panaxosides are attributed to ginseng's miraculous efficacy towards anti-aging, rejuvenating, and immune-potentiating benefits. The major ginsenosides such as Rb1, Rb2, Rc, Rd., Re, and Rg1, formed after extensive glycosylations of the aglycone "dammaranediol," dominate the chemical profile of this genus in vivo and in vitro. Elicitations have successfully led to appreciable enhancements in the production of these major ginsenosides...
April 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28393568/assessment-of-radical-scavenging-whitening-and-moisture-retention-activities-of-panax-ginseng-berry-mediated-gold-nanoparticles-as-safe-and-efficient-novel-cosmetic-material
#17
Zuly Jiménez, Yeon-Ju Kim, Ramya Mathiyalagan, Kwang-Hoon Seo, Padmanaban Mohanan, Jong-Chan Ahn, Yu-Jin Kim, Deok Chun Yang
Panax ginseng berry extract possess remarkable pharmacological effects on skin treatment such as anti-aging, antioxidant, promotor of collagen synthesis and alleviation against atopic dermatitis. In recent years, gold nanoparticles have gained much attention due to their extensive range of applications in particular in the field of drug delivery as a result of their biological compatibility and low toxicity. In a previous study, we designed and developed biocompatible gold and silver nanoparticles based on phytochemical profile and pharmacological efficacy of P...
April 9, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28379603/the-ginsenoside-derivative-20-s-protopanaxadiol-inhibits-solar-ultraviolet-light-induced-matrix-metalloproteinase-1-expression
#18
Eungmin Han, Tae-Gyu Lim, Jong-Eun Kim, Hee Yang, Deok-Kun Oh, Jung Han Yoon Park, Dalius Yoon Park, Hee Jung Kim, Young Kyoung Rhee, Ki Won Lee
Ginsenosides are major pharmacologically active compounds present in ginseng (Panax ginseng). Among the ginsenosides, 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (GPPD) and ginsenoside Rb1 (Rb1) have previously been reported to exhibit anti-wrinkle effects. In this study, 20(S)-protopanaxadiol (20(S)-PPD), an aglycone derivative of the Rb1 metabolite was investigated for its anti-wrinkle benefit and compared to GPPD and Rb1. The anti-wrinkle effect of 20(S)-PPD during solar UV light was investigated using a human skin equivalent model and human keratinocytes...
April 5, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28378809/corrigendum-effect-of-the-interaction-of-veratrum-nigrum-with-panax-ginseng-on-estrogenic-activity-in-vivo-and-in-vitro
#19
Ying Xu, Jie Ding, Jin-Na An, Ya-Kun Qu, Xin Li, Xiao-Ping Ma, Yi-Min Zhang, Guo-Jing Dai, Na Lin
No abstract text is available yet for this article.
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28371286/impairment-of-preimplantation-and-postimplantation-embryonic-development-through-intrinsic-apoptotic-processes-by-ginsenoside-rg1-in-vitro-and-in-vivo
#20
Madonna Rica Anggelia, Wen-Hsiung Chan
Ginsenoside Rg1, which is the most abundant compound found in Asian ginseng (Panax ginseng), has demonstrated various pharmacological actions, including neuroprotective, immune-stimulatory, and antidiabetic effects. Pregnant women, especially in the Asian community, consume ginseng as a nutritive supplement. Thus, the effects of ginsenoside-Rg1 on embryonic development need to be investigated, such as in a mouse model. As previous investigations have found that ginsenoside Rg1 appears to either trigger or prevent apoptosis in different cell lines, the effects of this agent on apoptosis remain to be clarified...
March 29, 2017: Environmental Toxicology
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