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https://www.readbyqxmd.com/read/29928264/identification-of-conserved-amino-acid-substitutions-during-serial-infection-of-pregnant-cattle-and-sheep-with-bovine-viral-diarrhea-virus
#1
Thibaud Kuca, Thomas Passler, Benjamin W Newcomer, John D Neill, Patricia K Galik, Kay P Riddell, Yijing Zhang, Paul H Walz
Bovine viral diarrhea virus (BVDV) is an economically important pathogen of cattle that can also infect a wide range of domestic and wild species including sheep, goats, deer, camelids, and pigs. BVDV isolates are genetically highly diverse and previous work demonstrated that many substitutions were introduced in the viral genome during acute infections in cattle. In contrast, only limited information exists regarding changes occurring during BVDV infections in species other than cattle. The purpose of this study was to determine the changes introduced in the open reading frame (ORF) of the BVDV genome during serial infection of pregnant cattle and sheep with an isolate of bovine origin...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29927552/generation-and-identification-of-mutations-resulting-in-chronic-and-age-related-phenotypes-in-mice
#2
Andrew Blease, Thomas Nicol, Sara Falcone, Becky Starbuck, Simon Greenaway, Marie Hutchinson, Paul K Potter
Aging is inevitable, and our society must deal with the consequences: namely, an increased incidence of disease and ill health. Many mouse models of disease are acute or early onset or are induced in young mice, despite the fact that aging is a significant risk factor for a range of significant diseases. To improve modeling of such diseases, we should incorporate aging into our models. Many systems are affected by aging, with a decline in mitochondrial function, an increase in senescence, a loss of resilience, telomere shortening, and a decline in immune function being key factors in the increased susceptibility to disease that is associated with aging...
June 2018: Current Protocols in Mouse Biology
https://www.readbyqxmd.com/read/29926944/periodontal-health-and-gingival-diseases-and-conditions-on-an-intact-and-a-reduced-periodontium-consensus-report-of-workgroup-1-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#3
Iain L C Chapple, Brian L Mealey, Thomas E Van Dyke, P Mark Bartold, Henrik Dommisch, Peter Eickholz, Maria L Geisinger, Robert J Genco, Michael Glogauer, Moshe Goldstein, Terrence J Griffin, Palle Holmstrup, Georgia K Johnson, Yvonne Kapila, Niklaus P Lang, Joerg Meyle, Shinya Murakami, Jacqueline Plemons, Giuseppe A Romito, Lior Shapira, Dimitris N Tatakis, Wim Teughels, Leonardo Trombelli, Clemens Walter, Gernot Wimmer, Pinelopi Xenoudi, Hiromasa Yoshie
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium in either a non-periodontitis patient (e.g. in patients with some form of gingival recession or following crown lengthening surgery) or in a patient with a history of periodontitis who is currently periodontally stable...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926740/the-role-of-social-media-and-internet-search-engines-in-information-provision-and-dissemination-to-patients-with-kidney-stone-disease-ksd-a-systematic-review-from-eau-young-academic-urologists-yau
#4
Enakshee Jamnadass, Omar Aboumarzouk, Panagiotis Kallidonis, Esteban Emiliani, Thomas Tailly, Stephan Hruby, Francesco Sanguedolce, Gokhan Atis, Mehmet Özsoy, Francesco Greco, Bhaskar K Somani
INTRODUCTION: Kidney stone disease (KSD) affects millions of people worldwide and has an increasing incidence. Social media (SoMe) and search engines are both gaining in usage, whilst also being used by patients to research their conditions and aid in managing them. With this in mind, many authors have expressed the belief that SoMe and search engines can be used by patients and healthcare professionals to improve treatment compliance, and to help counselling and management of conditions such as KSD...
June 21, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29926499/periodontal-health-and-gingival-diseases-and-conditions-on-an-intact-and-a-reduced-periodontium-consensus-report-of-workgroup-1-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#5
Iain L C Chapple, Brian L Mealey, Thomas E Van Dyke, P Mark Bartold, Henrik Dommisch, Peter Eickholz, Maria L Geisinger, Robert J Genco, Michael Glogauer, Moshe Goldstein, Terrence J Griffin, Palle Holmstrup, Georgia K Johnson, Yvonne Kapila, Niklaus P Lang, Joerg Meyle, Shinya Murakami, Jacqueline Plemons, Giuseppe A Romito, Lior Shapira, Dimitris N Tatakis, Wim Teughels, Leonardo Trombelli, Clemens Walter, Gernot Wimmer, Pinelopi Xenoudi, Hiromasa Yoshie
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium in either a non-periodontitis patient (e.g. in patients with some form of gingival recession or following crown lengthening surgery) or in a patient with a history of periodontitis who is currently periodontally stable...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29923287/ground-state-structure-of-the-proton-bound-formate-dimer-by-cold-ion-infrared-action-spectroscopy
#6
Daniel Thomas, Mateusz Marianski, Eike Mucha, Gerard Meijer, Mark A Johnson, Gert von Helden
The proton-bound dicarboxylate motif, RCOO-·H+·-OOCR, is a prevalent chemical configuration found in many condensed phase systems. We study the archetypal proton-bound formate dimer, HCOO-·H+·-OOCH, utilizing cold-ion infrared action spectroscopy in the photon energy range of 400-1800 cm-1. The spectrum obtained at ~0.4 K utilizing action spectroscopy of ions captured in helium nanodroplets is compared to that measured at ~10 K by photodissociation of Ar-ion complexes. Similar band patterns are obtained by the two techniques that are consistent with calculations for a C2 symmetry structure with a proton shared equally between the two formate moieties...
June 19, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29922565/neuroma-implantation-into-long-bones-clinical-foundation-for-a-novel-osseointegrated-peripheral-nerve-interface
#7
Jacqueline S Israel, Aaron M Dingle, Ruston J Sanchez, Sahil K Kapur, Sarah Brodnick, Thomas J Richner, Jared P Ness, Joseph Novello, Justin C Williams, Samuel O Poore
Symptomatic neuroma after major extremity amputation is a challenging clinical problem for which there are many described treatment options. Neuroma excision and implantation into the medullary canal of long bones offers durability and insulation, and minimizes chronic pain. Another challenge in amputees is impaired function and an ongoing need for accessible and functional prostheses that are "bidirectional," in that they provide both fine motor control and sensory feedback. Drawing on clinical experience with neuroma implantation into the medullary canal of long bones, the authors propose a novel neural interface whereby a terminal nerve end is redirected into the medullary canal of a nearby long bone and interfaced with an electrode array...
May 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29917104/binning-enables-efficient-host-genome-reconstruction-in-cnidarian-holobionts
#8
Juan Sebastián Celis, Daniel Wibberg, Catalina Ramírez-Portilla, Oliver Rupp, Alexander Sczyrba, Anika Winkler, Jörn Kalinowski, Thomas Wilke
Background: Many cnidarians, including stony corals, engage in complex symbiotic associations, comprising the eukaryotic host, photosynthetic algae, and highly diverse microbial communities-together referred to as holobiont. This taxonomic complexity makes sequencing and assembling coral host genomes extremely challenging. Therefore, previous cnidarian genomic projects were based on symbiont-free tissue samples. However, this approach may not be applicable to the majority of cnidarian species for ecological reasons...
June 18, 2018: GigaScience
https://www.readbyqxmd.com/read/29912205/the-mplex-protocol-for-multi-omic-analyses-of-soil-samples
#9
Carrie D Nicora, Kristin E Burnum-Johnson, Ernesto S Nakayasu, Cameron P Casey, Richard A White, Taniya Roy Chowdhury, Jennifer E Kyle, Young-Mo Kim, Richard D Smith, Thomas O Metz, Janet K Jansson, Erin S Baker
Mass spectrometry (MS)-based integrated metaproteomic, metabolomic, and lipidomic (multi-omic) studies are transforming our ability to understand and characterize microbial communities in environmental and biological systems. These measurements are even enabling enhanced analyses of complex soil microbial communities, which are the most complex microbial systems known to date. Multi-omic analyses, however, do have sample preparation challenges, since separate extractions are typically needed for each omic study, thereby greatly amplifying the preparation time and amount of sample required...
May 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29906203/radiographic-review-of-current-therapeutic-and-monitoring-devices-in-the-chest
#10
Christopher J G Sigakis, Susan K Mathai, Thomas D Suby-Long, Nicole L Restauri, Daniel Ocazionez, Tami J Bang, Carlos S Restrepo, Peter B Sachs, Daniel Vargas
Chest radiographs are obtained as a standard part of clinical care. Rapid advancements in medical technology have resulted in a myriad of new medical devices, and familiarity with their imaging appearance is a critical yet increasingly difficult endeavor. Many modern thoracic medical devices are new renditions of old designs and are often smaller than older versions. In addition, multiple device designs serving the same purpose may have varying morphologies and positions within the chest. The radiologist must be able to recognize and correctly identify the proper positioning of state-of-the-art medical devices and identify any potential complications that could impact patient care and management...
June 15, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29898845/predictors-of-oral-anticoagulant-non-prescription-in-patients-with-atrial-fibrillation-and-elevated-stroke-risk
#11
Steven A Lubitz, Shaan Khurshid, Lu-Chen Weng, Gheorghe Doros, Joseph Walker Keach, Qi Gao, Anil K Gehi, Jonathan C Hsu, Matthew R Reynolds, Mintu P Turakhia, Thomas M Maddox
BACKGROUND: Many patients with atrial fibrillation (AF) and elevated stroke risk are not prescribed oral anticoagulation (OAC) despite evidence of benefit. Identification of factors associated with OAC non-prescription could lead to improvements in care. METHODS AND RESULTS: Using NCDR PINNACLE, a United States-based ambulatory cardiology registry, we examined factors associated with OAC non-prescription in patients with non-valvular AF at elevated stroke risk (CHA2 DS2 -VASc ≥2) between January 5, 2008 and December 31, 2014...
June 2018: American Heart Journal
https://www.readbyqxmd.com/read/29893009/estimating-mental-health-impacts-of-alcohol-s-harms-from-other-drinkers-using-propensity-scoring-methods-with-national-cross-sectional-data-from-the-u-s
#12
Katherine J Karriker-Jaffe, Libo Li, Thomas K Greenfield
BACKGROUND & AIMS: Alcohol's harms to others (AHTO) may cause substantial distress, particularly when harms are perpetrated by close others. One challenge to identifying causal impacts is that people harmed by drinkers differ in many ways from those not so harmed, so our aim was to assess mental health in relation to two serious types of AHTO, financial harm and assault by someone who had been drinking, using propensity score (PS) weighting to adjust for potentially confounding differences...
June 12, 2018: Addiction
https://www.readbyqxmd.com/read/29885081/variation-in-flexural-stiffness-of-the-lepidotrichia-within-and-among-the-soft-fins-of-yellow-perch-under-different-preservation-techniques
#13
Natalia K Taft, Benjamin N Taft, Hailey Henck, Thomas Mehner
Although the ray-finned fishes are named for their bony, segmented lepidotrichia (fin rays), we are only beginning to understand the morphological and functional diversity of this key vertebrate structure. Fin rays support the fin web, and their material properties help define the function of the entire fin. Many earlier studies of fin ray morphology and function have focused on isolated rays, or on rays from only one or two fins. At the same time, relatively little is known about how different preservation techniques affect the material properties of many vertebrate structures, including fin rays...
June 8, 2018: Journal of Morphology
https://www.readbyqxmd.com/read/29875409/oxidized-phospholipids-are-proinflammatory-and-proatherogenic-in-hypercholesterolaemic-mice
#14
Xuchu Que, Ming-Yow Hung, Calvin Yeang, Ayelet Gonen, Thomas A Prohaska, Xiaoli Sun, Cody Diehl, Antti Määttä, Dalia E Gaddis, Karen Bowden, Jennifer Pattison, Jeffrey G MacDonald, Seppo Ylä-Herttuala, Pamela L Mellon, Catherine C Hedrick, Klaus Ley, Yury I Miller, Christopher K Glass, Kirk L Peterson, Christoph J Binder, Sotirios Tsimikas, Joseph L Witztum
Oxidized phospholipids (OxPL) are ubiquitous, are formed in many inflammatory tissues, including atherosclerotic lesions, and frequently mediate proinflammatory changes 1 . Because OxPL are mostly the products of non-enzymatic lipid peroxidation, mechanisms to specifically neutralize them are unavailable and their roles in vivo are largely unknown. We previously cloned the IgM natural antibody E06, which binds to the phosphocholine headgroup of OxPL, and blocks the uptake of oxidized low-density lipoprotein (OxLDL) by macrophages and inhibits the proinflammatory properties of OxPL2-4 ...
June 6, 2018: Nature
https://www.readbyqxmd.com/read/29872359/what-a-medical-school-chair-wants-from-the-dean
#15
Robert Hromas, Robert Leverence, Lazarus K Mramba, J Larry Jameson, Caryn Lerman, Thomas L Schwenk, Ellen M Zimmermann, Michael L Good
Economic pressure has led the evolution of the role of the medical school dean from a clinician educator to a health care system executive. In addition, other dynamic requirements also have likely led to changes in their leadership characteristics. The most important relationship a dean has is with the chairs, yet in the context of the dean's changing role, little attention has been paid to this relationship. To frame this discussion, we asked medical school chairs what characteristics of a dean's leadership were most beneficial...
2018: Journal of Healthcare Leadership
https://www.readbyqxmd.com/read/29866410/follow-up-imaging-after-acute-evaluations-for-pediatric-nephrolithiasis-trends-from-a-national-database
#16
Jonathan S Ellison, Paul A Merguerian, Benjamin C Fu, Sarah K Holt, Thomas S Lendvay, John L Gore, Margarett Shnorhavorian
BACKGROUND: Overuse of computed tomography (CT) in the initial evaluation of children with upper urinary tract calculi (UUTC) has been well documented. Follow-up imaging patterns, however, remain undefined. Sequential imaging following an acute episode of UUTC represents additional opportunity for enacting good imaging stewardship, with the optimal goal to reduce unnecessary radiation exposure and cost while ensuring appropriate follow-up. OBJECTIVE: We explored nationwide imaging patterns for children following emergency department (ED) evaluations for UUTC, hypothesizing that initial imaging choice and complicated visits for UUTC increase the risk of follow-up CT scans...
May 24, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29859740/deferred-treatment-with-sofosbuvir-velpatasvir-voxilaprevir-for-patients-with-chronic-hepatitis-c-virus-who-were-previously-treated-with-an-ns5a-inhibitor-an-open-label-substudy-of-polaris-1
#17
Marc Bourlière, Stuart C Gordon, Eugene R Schiff, Tram T Tran, Natarajan Ravendhran, Charles S Landis, Robert H Hyland, Luisa M Stamm, Jie Zhang, Hadas Dvory-Sobol, G Mani Subramanian, Diana M Brainard, John G McHutchison, Lawrence Serfaty, Alex J Thompson, Thomas E Sepe, Michael P Curry, K Rajender Reddy, Michael P Manns
BACKGROUND: Direct-acting antiviral regimens containing NS5A inhibitors are highly effective treatments for chronic hepatitis C virus (HCV) infection, but are not always successful. In the POLARIS-1 phase 3 study, sofosbuvir-velpatasvir-voxilaprevir for 12 weeks was highly effective in the treatment of chronic HCV infection in patients previously treated with a direct-acting antiviral regimen containing an NS5A inhibitor. We aimed to assess the efficacy and safety of sofosbuvir-velpatasvir-voxilaprevir in patients from the deferred treatment group of POLARIS-1, who were initially assigned to masked placebo treatment...
May 30, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29858102/seafood-allergy-a-comprehensive-review-of-fish-and-shellfish-allergens
#18
Thimo Ruethers, Aya C Taki, Elecia B Johnston, Roni Nugraha, Thu T K Le, Tanja Kalic, Thomas R McLean, Sandip D Kamath, Andreas L Lopata
Seafood refers to several distinct groups of edible aquatic animals including fish, crustacean, and mollusc. The two invertebrate groups of crustacean and mollusc are, for culinary reasons, often combined as shellfish but belong to two very different phyla. The evolutionary and taxonomic diversity of the various consumed seafood species poses a challenge in the identification and characterisation of the major and minor allergens critical for reliable diagnostics and therapeutic treatments. Many allergenic proteins are very different between these groups; however, some pan-allergens, including parvalbumin, tropomyosin and arginine kinase, seem to induce immunological and clinical cross-reactivity...
May 29, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29851235/dominance-diversity-relationships-in-ant-communities-differ-with-invasion
#19
Xavier Arnan, Alan N Andersen, Heloise Gibb, Catherine L Parr, Nathan J Sanders, Robert R Dunn, Elena Angulo, Fabricio B Baccaro, Tom R Bishop, Raphaël Boulay, Cristina Castracani, Xim Cerdá, Israel Del Toro, Thibaut Delsinne, David A Donoso, Emilie K Elten, Tom M Fayle, Matthew C Fitzpatrick, Crisanto Gómez, Donato A Grasso, Blair F Grossman, Benoit Guénard, Nihara Gunawardene, Brian Heterick, Benjamin D Hoffmann, Milan Janda, Clinton N Jenkins, Petr Klimes, Lori Lach, Thomas Laeger, Maurice Leponce, Andrea Lucky, Jonathan Majer, Sean Menke, Dirk Mezger, Alessandra Mori, Jimmy Moses, Thinandavha Caswell Munyai, Omid Paknia, Martin Pfeiffer, Stacy M Philpott, Jorge L P Souza, Melanie Tista, Heraldo L Vasconcelos, Javier Retana
The relationship between levels of dominance and species richness is highly contentious, especially in ant communities. The dominance-impoverishment rule states that high levels of dominance only occur in species-poor communities, but there appear to be many cases of high levels of dominance in highly diverse communities. The extent to which dominant species limit local richness through competitive exclusion remains unclear, but such exclusion appears more apparent for non-native rather than native dominant species...
May 30, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29848375/an-update-on-the-society-for-immunotherapy-of-cancer-consensus-statement-on-tumor-immunotherapy-for-the-treatment-of-cutaneous-melanoma-version-2-0
#20
Ryan J Sullivan, Michael B Atkins, John M Kirkwood, Sanjiv S Agarwala, Joseph I Clark, Marc S Ernstoff, Leslie Fecher, Thomas F Gajewski, Brian Gastman, David H Lawson, Jose Lutzky, David F McDermott, Kim A Margolin, Janice M Mehnert, Anna C Pavlick, Jon M Richards, Krista M Rubin, William Sharfman, Steven Silverstein, Craig L Slingluff, Vernon K Sondak, Ahmad A Tarhini, John A Thompson, Walter J Urba, Richard L White, Eric D Whitman, F Stephen Hodi, Howard L Kaufman
BACKGROUND: Cancer immunotherapy has been firmly established as a standard of care for patients with advanced and metastatic melanoma. Therapeutic outcomes in clinical trials have resulted in the approval of 11 new drugs and/or combination regimens for patients with melanoma. However, prospective data to support evidence-based clinical decisions with respect to the optimal schedule and sequencing of immunotherapy and targeted agents, how best to manage emerging toxicities and when to stop treatment are not yet available...
May 30, 2018: Journal for Immunotherapy of Cancer
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