keyword
MENU ▼
Read by QxMD icon Read
search

Mani k thomas

keyword
https://www.readbyqxmd.com/read/29676732/donated-chemical-probes-for-open-science
#1
Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart Mj Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia Yi Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose...
April 20, 2018: ELife
https://www.readbyqxmd.com/read/29674451/fully-reduced-hmgb1-accelerates-the-regeneration-of-multiple-tissues-by-transitioning-stem-cells-to-g-alert
#2
Geoffrey Lee, Ana Isabel Espirito Santo, Stefan Zwingenberger, Lawrence Cai, Thomas Vogl, Marc Feldmann, Nicole J Horwood, James K Chan, Jagdeep Nanchahal
A major discovery of recent decades has been the existence of stem cells and their potential to repair many, if not most, tissues. With the aging population, many attempts have been made to use exogenous stem cells to promote tissue repair, so far with limited success. An alternative approach, which may be more effective and far less costly, is to promote tissue regeneration by targeting endogenous stem cells. However, ways of enhancing endogenous stem cell function remain poorly defined. Injury leads to the release of danger signals which are known to modulate the immune response, but their role in stem cell-mediated repair in vivo remains to be clarified...
April 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29669589/similarity-of-the-dog-and-human-gut-microbiomes-in-gene-content-and-response-to-diet
#3
Luis Pedro Coelho, Jens Roat Kultima, Paul Igor Costea, Coralie Fournier, Yuanlong Pan, Gail Czarnecki-Maulden, Matthew Robert Hayward, Sofia K Forslund, Thomas Sebastian Benedikt Schmidt, Patrick Descombes, Janet R Jackson, Qinghong Li, Peer Bork
BACKGROUND: Gut microbes influence their hosts in many ways, in particular by modulating the impact of diet. These effects have been studied most extensively in humans and mice. In this work, we used whole genome metagenomics to investigate the relationship between the gut metagenomes of dogs, humans, mice, and pigs. RESULTS: We present a dog gut microbiome gene catalog containing 1,247,405 genes (based on 129 metagenomes and a total of 1.9 terabasepairs of sequencing data)...
April 19, 2018: Microbiome
https://www.readbyqxmd.com/read/29656858/a-recurrent-de-novo-pacs2-heterozygous-missense-variant-causes-neonatal-onset-developmental-epileptic-encephalopathy-facial-dysmorphism-and-cerebellar-dysgenesis
#4
Heather E Olson, Nolwenn Jean-Marçais, Edward Yang, Delphine Heron, Katrina Tatton-Brown, Paul A van der Zwaag, Emilia K Bijlsma, Bryan L Krock, E Backer, Erik-Jan Kamsteeg, Margje Sinnema, Margot R F Reijnders, David Bearden, Amber Begtrup, Aida Telegrafi, Roelineke J Lunsing, Lydie Burglen, Gaetan Lesca, Megan T Cho, Lacey A Smith, Beth R Sheidley, Christelle Moufawad El Achkar, Phillip L Pearl, Annapurna Poduri, Cara M Skraban, Jennifer Tarpinian, Addie I Nesbitt, Dietje E Fransen van de Putte, Claudia A L Ruivenkamp, Patrick Rump, Nicolas Chatron, Isabelle Sabatier, Julitta De Bellescize, Laurent Guibaud, David A Sweetser, Jessica L Waxler, Klaas J Wierenga, Jean Donadieu, Vinodh Narayanan, Keri M Ramsey, Caroline Nava, Jean-Baptiste Rivière, Antonio Vitobello, Frédéric Tran Mau-Them, Christophe Philippe, Ange-Line Bruel, Yannis Duffourd, Laurel Thomas, Stefan H Lelieveld, Janneke Schuurs-Hoeijmakers, Han G Brunner, Boris Keren, Julien Thevenon, Laurence Faivre, Gary Thomas, Christel Thauvin-Robinet
Developmental and epileptic encephalopathies (DEEs) represent a large clinical and genetic heterogeneous group of neurodevelopmental diseases. The identification of pathogenic genetic variants in DEEs remains crucial for deciphering this complex group and for accurately caring for affected individuals (clinical diagnosis, genetic counseling, impacting medical, precision therapy, clinical trials, etc.). Whole-exome sequencing and intensive data sharing identified a recurrent de novo PACS2 heterozygous missense variant in 14 unrelated individuals...
April 10, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29651696/diversity-of-the-midstream-urine-microbiome-in-adults-with-chronic-kidney-disease
#5
Holly Kramer, Gina Kuffel, Krystal Thomas-White, Alan J Wolfe, Kavitha Vellanki, David J Leehey, Vinod K Bansal, Linda Brubaker, Robert Flanigan, Julia Koval, Anuradha Wadhwa, Michael J Zilliox
PURPOSE: To examine the characteristics of the midstream urine microbiome in adults with stage 3-5 non-dialysis-dependent chronic kidney disease (CKD). METHODS: Patients with non-dialysis-dependent CKD (estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m2 ) and diuretic use were recruited from outpatient nephrology clinics. Midstream voided urine specimens were collected using the clean-catch method. The bacterial composition was determined by sequencing the hypervariable (V4) region of the bacterial 16S ribosomal RNA gene...
April 12, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29643123/intragenic-transcriptional-interference-regulates-the-human-immune-ligand-mica
#6
Da Lin, Thomas K Hiron, Christopher A O'Callaghan
Many human genes have tandem promoters driving overlapping transcription, but the value of this distributed promoter configuration is generally unclear. Here we show that MICA , a gene encoding a ligand for the activating immune receptor NKG2D, contains a conserved upstream promoter that expresses a noncoding transcript. Transcription from the upstream promoter represses the downstream standard promoter activity in cis through transcriptional interference. The effect of transcriptional interference depends on the strength of transcription from the upstream promoter and can be described quantitatively by a simple reciprocal repressor function...
April 11, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29627334/preoperative-risk-score-to-predict-occult-metastatic-or-locally-advanced-disease-in-patients-with-resectable-perihilar-cholangiocarcinoma-on-imaging
#7
Jimme K Wiggers, Bas Groot Koerkamp, David van Klaveren, Robert J Coelen, C Yung Nio, Peter J Allen, Marc G Besselink, Olivier R Busch, Michael I D'Angelica, Ronald P DeMatteo, T Peter Kingham, Thomas M van Gulik, William R Jarnagin
BACKGROUND: Many patients with resectable perihilar cholangiocarcinoma (PHC) on imaging are intra-operatively diagnosed with occult metastatic or locally advanced disease precluding a curative-intent resection. This study aimed to develop and validate a preoperative risk score. STUDY DESIGN: Patients with resectable PHC on imaging who underwent surgery in two high-volume centers (USA and Europe) between 2000 and 2015 were included. Multivariable logistic regression analysis was used to develop the risk score...
April 5, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29626461/enoxaparin-40mg-per-day-is-inadequate-for-venous-thromboembolism-prophylaxis-after-thoracic-surgery
#8
Christopher J Pannucci, Kory I Fleming, Kathleen Holoyda, Lauren Moulton, Ann Marie Prazak, Thomas K Varghese
BACKGROUND: Many thoracic surgery patients have venous thromboembolism (VTE) events despite the receipt of chemical prophylaxis. Enoxaparin's pharmacologic impact can be quantified using anti-Factor Xa (aFXa) levels. We hypothesized that enoxaparin 40mg once daily would be inadequate for most thoracic surgery inpatients and that a real time dose adjustment algorithm would be impactful. METHODS: This prospective clinical trial enrolled thoracic surgery inpatients who were placed on enoxaparin 40mg once daily for VTE prophylaxis after surgical procedures...
April 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29626094/the-substrate-binding-cap-of-the-udp-diacylglucosamine-pyrophosphatase-lpxh-is-highly-flexible-enabling-facile-substrate-binding-and-product-release
#9
Thomas E Bohl, Pek Ieong, John K Lee, Thomas Lee, Jayakanth Kankanala, Ke Shi, Özlem Demir, Kayo Kurahashi, Rommie E Amaro, Zhengqiang Wang, Hideki Aihara
Gram-negative bacteria are surrounded by a secondary membrane of which the outer leaflet is composed of the glycolipid lipopolysaccharide (LPS), which guards against hydrophobic toxins, including many antibiotics. Therefore, LPS synthesis in bacteria is an attractive target for antibiotic development. LpxH is a pyrophosphatase involved in LPS synthesis, and previous structures revealed that LpxH has a helical cap that binds its lipid substrates. Here, crystallography and hydrogen-deuterium exchange mass spectrometry provided evidence for a highly flexible substrate-binding cap in LpxH...
April 6, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29620876/electron-rich-diiron-bis-monothiolato-carbonyls-c-s-bond-homolysis-in-a-mixed-valence-diiron-dithiolate
#10
Qianli Li, Noémie Lalaoui, Toby J Woods, Thomas B Rauchfuss, Federica Arrigoni, Giuseppe Zampella
The synthesis and redox properties are presented for the electron-rich bis(monothiolate)s Fe2 (SR)2 (CO)2 (dppv)2 for R = Me ([1]0 ), Ph ([2]0 ), CH2 Ph ([3]0 ). Whereas related derivatives adopt C2 -symmetric Fe2 (CO)2 P4 cores, [1]0 -[3]0 have Cs symmetry resulting from the unsymmetrical steric properties of the axial vs equatorial R groups. Complexes [1]0 -[3]0 undergo 1e- oxidation upon treatment with ferrocenium salts to give the mixed valence cations [Fe2 (SR)2 (CO)2 (dppv)2 ]+ . As established crystallographically, [3]+ adopts a rotated structure, characteristic of related mixed valence diiron complexes...
April 5, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29615005/improving-risk-prediction-accuracy-for-new-soldiers-in-the-u-s-army-by-adding-self-report-survey-data-to-administrative-data
#11
Samantha L Bernecker, Anthony J Rosellini, Matthew K Nock, Wai Tat Chiu, Peter M Gutierrez, Irving Hwang, Thomas E Joiner, James A Naifeh, Nancy A Sampson, Alan M Zaslavsky, Murray B Stein, Robert J Ursano, Ronald C Kessler
BACKGROUND: High rates of mental disorders, suicidality, and interpersonal violence early in the military career have raised interest in implementing preventive interventions with high-risk new enlistees. The Army Study to Assess Risk and Resilience in Servicemembers (STARRS) developed risk-targeting systems for these outcomes based on machine learning methods using administrative data predictors. However, administrative data omit many risk factors, raising the question whether risk targeting could be improved by adding self-report survey data to prediction models...
April 3, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29611822/autoinhibitory-regulation-of-s100a8-s100a9-alarmin-activity-locally-restricts-sterile-inflammation
#12
Thomas Vogl, Athanasios Stratis, Viktor Wixler, Tom Völler, Sumita Thurainayagam, Selina K Jorch, Stefanie Zenker, Alena Dreiling, Deblina Chakraborty, Mareike Fröhling, Peter Paruzel, Corinna Wehmeyer, Sven Hermann, Olympia Papantonopoulou, Christiane Geyer, Karin Loser, Michael Schäfers, Stephan Ludwig, Monika Stoll, Tomas Leanderson, Joachim L Schultze, Simone König, Thomas Pap, Johannes Roth
Autoimmune diseases, such as psoriasis and arthritis, show a patchy distribution of inflammation despite systemic dysregulation of adaptive immunity. Thus, additional tissue-derived signals, such as danger-associated molecular patterns (DAMPs), are indispensable for manifestation of local inflammation. S100A8/S100A9 complexes are the most abundant DAMPs in many autoimmune diseases. However, regulatory mechanisms locally restricting DAMP activities are barely understood. We now unravel for the first time, to our knowledge, a mechanism of autoinhibition in mice and humans restricting S100-DAMP activity to local sites of inflammation...
April 3, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29610075/low-frequency-conductivity-tensor-imaging-of-the-human-head-in-vivo-using-dt-mreit-first-study
#13
Munish Chauhan, Aprinda Indahlastari, Aditya K Kasinadhuni, Michael Schar, Thomas H Mareci, Rosalind J Sadleir
We present the first in vivo images of anisotropic conductivity distribution in the human head, measured at a frequency of approximately 10 Hz. We used magnetic resonance electrical impedance tomography techniques to encode phase changes caused by current flow within the head via two independent electrode pairs. These results were then combined with diffusion tensor imaging data to reconstruct full anisotropic conductivity distributions in 5-mm-thick slices of the brains of two participants. Conductivity values recovered in this paper were broadly consistent with literature values...
April 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29603953/iterative-optimization-in-tomographic-deconvolution-phase-microscopy
#14
Yijun Bao, Thomas K Gaylord
Tomographic deconvolution phase microscopy (TDPM) is a three-dimensional (3D) quantitative phase imaging (QPI) method using partially coherent light that can be implemented on a commercial microscope platform. However, the measurement procedure is relatively time-consuming because it requires many illumination angles. In the present work, an edge-preserving iterative optimization algorithm is presented and applied to TDPM, so that the required number of illumination angles is reduced from 15 to 3, while the measurement accuracy remains high...
April 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29600282/investigating-colonization-of-the-healthy-adult-gastrointestinal-tract-by-fungi
#15
Thomas A Auchtung, Tatiana Y Fofanova, Christopher J Stewart, Andrea K Nash, Matthew C Wong, Jonathan R Gesell, Jennifer M Auchtung, Nadim J Ajami, Joseph F Petrosino
A wide diversity of fungi have been detected in the human gastrointestinal (GI) tract with the potential to provide or influence important functions. However, many of the fungi most commonly detected in stool samples are also present in food or the oral cavity. Therefore, to recognize which gut fungi are likely to have a sustained influence on human health, there is a need to separate transient members of the GI tract from true colonizers. To identify colonizing fungi, the eukaryotic rRNA operon's second internal transcribed spacer (ITS2) was sequenced from the stool, saliva, and food of healthy adults following consumption of different controlled diets...
March 2018: MSphere
https://www.readbyqxmd.com/read/29596725/antagonists-in-the-medical-management-of-opioid-use-disorders-historical-and-existing-treatment-strategies
#16
REVIEW
Adam Bisaga, Paolo Mannelli, Maria A Sullivan, Suzanne K Vosburg, Peggy Compton, George E Woody, Thomas R Kosten
BACKGROUND AND OBJECTIVES: Opioid use disorder (OUD) is a chronic condition with potentially severe health and social consequences. Many who develop moderate to severe OUD will repeatedly seek treatment or interact with medical care via emergency department visits or hospitalizations. Thus, there is an urgent need to develop feasible and effective approaches to help persons with OUD achieve and maintain abstinence from opioids. Treatment that includes one of the three FDA-approved medications is an evidence-based strategy to manage OUD...
April 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29596051/harmonization-initiatives-in-the-generation-reporting-and-application-of-biological-variation-data
#17
REVIEW
Aasne K Aarsand, Thomas Røraas, William A Bartlett, Abdurrahman Coşkun, Anna Carobene, Pilar Fernandez-Calle, Niels Jonker, Jorge Díaz-Garzón, Federica Braga, Sverre Sandberg
Biological variation (BV) data have many applications in laboratory medicine. However, concern has been raised that some BV estimates in use today may be irrelevant or of unacceptable quality. A number of initiatives have been launched by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) and other parties to deliver a more harmonized practice in the generation, reporting and application of BV data. Resulting from a necessary focus upon the veracity of historical BV studies, critical appraisal and meta-analysis of published BV studies is possible through application of the Biological Variation Data Critical Appraisal Checklist (BIVAC), published in 2017...
March 29, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29581486/distinct-thermodynamic-signatures-of-oligomer-generation-in-the-aggregation-of-the-amyloid-%C3%AE-peptide
#18
Samuel I A Cohen, Risto Cukalevski, Thomas C T Michaels, Anđela Šarić, Mattias Törnquist, Michele Vendruscolo, Christopher M Dobson, Alexander K Buell, Tuomas P J Knowles, Sara Linse
Mapping free-energy landscapes has proved to be a powerful tool for studying reaction mechanisms. Many complex biomolecular assembly processes, however, have remained challenging to access using this approach, including the aggregation of peptides and proteins into amyloid fibrils implicated in a range of disorders. Here, we generalize the strategy used to probe free-energy landscapes in protein folding to determine the activation energies and entropies that characterize each of the molecular steps in the aggregation of the amyloid-β peptide (Aβ42), which is associated with Alzheimer's disease...
March 26, 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29580293/effects-of-oncological-care-pathways-in-primary-and-secondary-care-on-patient-professional-and-health-systems-outcomes-protocol-for-a-systematic-review-and-meta-analysis
#19
Jolanda C van Hoeve, Robin W M Vernooij, Adegboyega K Lawal, Michelle Fiander, Peter Nieboer, Sabine Siesling, Thomas Rotter
BACKGROUND: The high impact of a cancer diagnosis on patients and their families and the increasing costs of cancer treatment call for optimal and efficient oncological care. To improve the quality of care and to minimize healthcare costs and its economic burden, many healthcare organizations introduce care pathways to improve efficiency across the continuum of cancer care. However, there is limited research on the effects of cancer care pathways in different settings. METHODS: The aim of this systematic review and meta-analysis described in this protocol is to synthesize existing literature on the effects of oncological care pathways...
March 27, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29580280/report-of-the-first-international-workshop-on-onchocerciasis-associated-epilepsy
#20
EDITORIAL
Robert Colebunders, Michel Mandro, Alfred K Njamnshi, Michel Boussinesq, An Hotterbeekx, Joseph Kamgno, Sarah O'Neill, Adrian Hopkins, Patrick Suykerbuyk, Maria-Gloria Basáñez, Rory J Post, Belén Pedrique, Pierre-Marie Preux, Wilma A Stolk, Thomas B Nutman, Richard Idro
BACKGROUND: Recently, several epidemiological studies performed in Onchocerca volvulus-endemic regions have suggested that onchocerciasis-associated epilepsy (OAE) may constitute an important but neglected public health problem in many countries where onchocerciasis is still endemic. MAIN TEXT: On October 12-14th 2017, the first international workshop on onchocerciasis-associated epilepsy (OAE) was held in Antwerp, Belgium. The workshop was attended by 79 participants from 20 different countries...
March 22, 2018: Infectious Diseases of Poverty
keyword
keyword
92738
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"