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https://www.readbyqxmd.com/read/29623515/dna-methylation-based-subclassification-of-psoriasis-in-the-chinese-han-population
#1
Fusheng Zhou, Changbing Shen, Yi-Hsiang Hsu, Jing Gao, Jinfa Dou, Randy Ko, Xiaodong Zheng, Liangdan Sun, Yong Cui, Xuejun Zhang
Psoriasis (Ps) is an inflammatory skin disease caused by genetic and environmental factors. Previous studies on DNA methylation (DNAm) found genetic markers that are closely associated with Ps, and evidence has shown that DNAm mediates genetic risk in Ps. In this study, Consensus Clustering was used to analyze DNAm data, and 114 Ps patients were divided into three subclassifications. Investigation of the clinical characteristics and copy number variations (CNVs) of DEFB4, IL22, and LCE3C in the three subclassifications revealed no significant differences in gender ratio and in Ps area and severity index (PASI) score...
April 5, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29614968/biological-clocks-and-physical-functioning-in-monozygotic-female-twins
#2
Elina Sillanpää, Eija K Laakkonen, Elina Vaara, Taina Rantanen, Vuokko Kovanen, Sarianna Sipilä, Jaakko Kaprio, Miina Ollikainen
BACKGROUND: Biomarkers of biological aging - DNA methylation age (DNAm age) and leukocyte telomere length (LTL)- correlate strongly with chronological age across the life course. It is, however, unclear how these measures of cellular wear and tear are associated with muscle strength and functional capacity, which are known to decline with older age and are associated with mortality. We investigated if DNAm age and LTL were associated with body composition and physical functioning by examining 48 monozygotic twin sisters...
April 4, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29564022/no-evidence-for-association-of-mthfr-677c-t-and-1298a-c-variants-with-placental-dna-methylation
#3
Giulia F Del Gobbo, E Magda Price, Courtney W Hanna, Wendy P Robinson
Background: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in one-carbon metabolism that ensures the availability of methyl groups for methylation reactions. Two single-nucleotide polymorphisms (SNPs) in the MTHFR gene, 677C>T and 1298A>C, result in a thermolabile enzyme with reduced function. These variants, in both the maternal and/or fetal genes, have been associated with pregnancy complications including miscarriage, neural tube defects (NTDs), and preeclampsia (PE), perhaps due to altered capacity for DNA methylation (DNAm)...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29550821/blocking-cd226-promotes-allogeneic-transplant-immune-tolerance-and-improves-skin-graft-survival-by-increasing-the-frequency-of-regulatory-t-cells-in-a-murine-model
#4
Tian Liu, Dongliang Zhang, Yuan Zhang, Xiangsheng Xu, Bo Zhou, Liang Fang, Yun Zhang, Yingjun Su, Boquan Jin, Ran Zhuang, Shuzhong Guo
BACKGROUND/AIMS: Regulatory T cells (Tregs) play key roles in maintaining peripheral tolerance and preventing autoimmune disease. Treg modulation could be helpful in treating malignancies, autoimmune disease, and allergies, as well as to facilitate organ transplantation. Signals transduced by co-stimulatory molecules are essential for Treg differentiation, homeostasis, and function. One well-known active receptor, CD226, also known as DNAM-1 or PTA1, is an adhesion molecule that interacts primarily with CD155 and is involved in Treg differentiation and immune tolerance to transplanted tissue...
March 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29500431/integrative-analysis-of-omics-summary-data-reveals-putative-mechanisms-underlying-complex-traits
#5
Yang Wu, Jian Zeng, Futao Zhang, Zhihong Zhu, Ting Qi, Zhili Zheng, Luke R Lloyd-Jones, Riccardo E Marioni, Nicholas G Martin, Grant W Montgomery, Ian J Deary, Naomi R Wray, Peter M Visscher, Allan F McRae, Jian Yang
The identification of genes and regulatory elements underlying the associations discovered by GWAS is essential to understanding the aetiology of complex traits (including diseases). Here, we demonstrate an analytical paradigm of prioritizing genes and regulatory elements at GWAS loci for follow-up functional studies. We perform an integrative analysis that uses summary-level SNP data from multi-omics studies to detect DNA methylation (DNAm) sites associated with gene expression and phenotype through shared genetic effects (i...
March 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29492308/cadmium-exposure-and-age-associated-dna-methylation-changes-in-non-smoking-women-from-northern-thailand
#6
Kathryn Demanelis, Shama Virani, Justin A Colacino, Niladri Basu, Muneko Nishijo, Werawan Ruangyuttikarn, Witaya Swaddiwudhipong, Kowit Nambunmee, Laura S Rozek
DNA methylation changes with age, and may serve as a biomarker of aging. Cadmium (Cd) modifies cellular processes that promote aging and disrupts methylation globally. Whether Cd modifies aging processes by influencing establishment of age-associated methylation marks is currently unknown. In this pilot study, we characterized methylation profiles in > 450 000 CpG sites in 40 non-smoking women (age 40-80) differentially exposed to environmental Cd from Thailand. Based on specific gravity adjusted urinary Cd, we classified them as high (HE) and low (LE) exposed and age-matched within 5 years...
May 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29492307/pesticide-use-and-line-1-methylation-among-male-private-pesticide-applicators-in-the-agricultural-health-study
#7
Melannie Alexander, Stella Koutros, Matthew R Bonner, Kathryn Hughes Barry, Michael C R Alavanja, Gabriella Andreotti, Hyang-Min Byun, Ligong Chen, Laura E Beane Freeman, Jonathan N Hofmann, Freya Kamel, Lee E Moore, Andrea Baccarelli, Jennifer Rusiecki
Cancer risk may be associated with DNA methylation (DNAm) levels in Long Interspersed Nucleotide Element 1 (LINE-1), a surrogate for global DNAm. Exposure to certain pesticides may increase risk of particular cancers, perhaps mediated in part through global DNAm alterations. To date, human data on pesticide exposure and global DNAm alterations are limited. The goal of this study was to evaluate alterations of LINE-1 DNAm by pesticides in a variety of classes. Data from 596 cancer-free male participants enrolled in the Agricultural Health Study (AHS) were used to examine associations between use of 57 pesticides and LINE-1 DNAm measured via Pyrosequencing in peripheral blood leucocytes...
May 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29478063/epigenetics-early-adversity-and-child-and-adolescent-mental-health
#8
Edward D Barker
Epigenetic modification, such as DNA methylation (DNAm), is a mechanism that can help explain how early adversities can engender long-term vulnerability for mental health problems. At present, there is preliminary evidence to support the possibility of epigenetic mediation: environmental factors are reported to influence offspring DNAm, which in turn associate with child and adolescent psychopathology. However, all analyses have been correlational in nature and, as these studies have focussed on children and adolescents, DNAm has been based on peripheral tissue (cord blood, whole blood, buccal cells)...
February 23, 2018: Psychopathology
https://www.readbyqxmd.com/read/29433075/glucocorticoid-receptor-gene-methylation-moderates-the-association-of-childhood-trauma-and-cortisol-stress-reactivity
#9
Nina Alexander, Clemens Kirschbaum, Matthis Wankerl, Benjamin J Stauch, Tobias Stalder, Susann Steudte-Schmiedgen, Markus Muehlhan, Robert Miller
Exposure to childhood trauma (CT) has been linked to sustained dysregulations of major stress response systems, including findings of both exaggerated and attenuated hypothalamus-pituitary-adrenal (HPA) axis activity. Likewise, CT constitutes a common risk factor for a broad range of psychiatric conditions that involve distinct neuroendocrine profiles. In this study, we investigated the role of epigenetic variability in a stress-related gene as a potential mediator or moderator of such differential trajectories in CT survivors...
January 31, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29415463/changes-in-dna-methylation-from-age-18-to-pregnancy-in-type-1-2-and-17-t-helper-and-regulatory-t-cells-pathway-genes
#10
Sabrina Iqbal, Gabrielle A Lockett, John W Holloway, S Hasan Arshad, Hongmei Zhang, Akhilesh Kaushal, Sabarinath R Tetali, Nandini Mukherjee, Wilfried J J Karmaus
To succeed, pregnancies need to initiate immune biases towards T helper 2 (Th2) responses, yet little is known about what establishes this bias. Using the Illumina 450 K platform, we explored changes in DNA methylation (DNAm) of Th1, Th2, Th17, and regulatory T cell pathway genes before and during pregnancy. Female participants were recruited at birth (1989), and followed through age 18 years and their pregnancy (2011-2015). Peripheral blood DNAm was measured in 245 girls at 18 years; from among these girls, the DNAm of 54 women was repeatedly measured in the first (weeks 8-21, n = 39) and second (weeks 22-38, n = 35) halves of pregnancy, respectively...
February 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29399631/dna-methylation-as-a-mediator-of-the-association-between-prenatal-adversity-and-risk-factors-for-metabolic-disease-in-adulthood
#11
Elmar W Tobi, Roderick C Slieker, René Luijk, Koen F Dekkers, Aryeh D Stein, Kate M Xu, P Eline Slagboom, Erik W van Zwet, L H Lumey, Bastiaan T Heijmans
Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health in 422 individuals exposed to famine in utero and 463 (sibling) controls. We implemented a two-step analysis, namely, a genome-wide exploration across 342,596 cytosine-phosphate-guanine dinucleotides (CpGs) for potential mediators of the association between prenatal famine exposure and adult body mass index (BMI), serum triglycerides (TG), or glucose concentrations, which was followed by formal mediation analysis...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29383163/reduced-representation-bisulfite-sequencing-rrbs-of-dairy-goat-mammary-glands-reveals-dna-methylation-profiles-of-integrated-genome-wide-and-critical-milk-related-genes
#12
Xiaoyan Zhang, Sihuan Zhang, Lin Ma, Enhui Jiang, Han Xu, Rui Chen, Qing Yang, Hong Chen, Zhuanjian Li, Xianyong Lan
DNA methylation (DNAm), a major element of epigenetics, plays critical roles in individual development. Reduced representation bisulfite sequencing (RRBS) is an effective and economical method for analyzing the DNA methylation of a single base. The aims of this study were to determine the DNAm profiles of the methylation contexts (CGs and non-CGs) of lactation and dry periods of goat mammary glands using the RRBS, and to identify potential milk-related genes. The proportion of CG was the highest among all the sequence contexts...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29373860/cadmium-associated-differential-methylation-throughout-the-placental-genome-epigenome-wide-association-study-of-two-u-s-birth-cohorts
#13
Todd M Everson, Tracy Punshon, Brian P Jackson, Ke Hao, Luca Lambertini, Jia Chen, Margaret R Karagas, Carmen J Marsit
BACKGROUND: Cadmium (Cd) is a ubiquitous environmental toxicant that can accumulate in the placenta during pregnancy, where it may impair placental function and affect fetal development. OBJECTIVES: We aimed to investigate Cd-associated variations in placental DNA methylation (DNAM) and associations with gene expression; we also aimed to identify novel pathways involved in Cd-associated reproductive toxicity. METHODS: Using placental DNAM and Cd concentrations in the New Hampshire Birth Cohort Study (NHBCS, n =343) and the Rhode Island Child Health Study (RICHS, n =141), we performed an epigenome-wide association study (EWAS) between Cd and DNAM, adjusting for tissue heterogeneity using a reference-free method...
January 22, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29370095/innovative-clinical-perspectives-for-cik-cells-in-cancer-patients
#14
REVIEW
Martino Introna, Fabio Correnti
Cytokine-induced killer (CIK) cells are T lymphocytes that have acquired, in vitro, following extensive manipulation by Interferon gamma (IFN-γ), OKT3 and Interleukin 2 (IL-2) addition, the expression of several Natural Killer (NK) cell-surface markers. CIK cells have a dual "nature", due to the presence of functional TCR as well as NK molecules, even if the antitumoral activity can be traced back only to the NK-like structures (DNAM-1, NKG2D, NKp30 and CD56). In addition to antineoplastic activity in vitro and in several in-vivo models, CIK cells show very limited, if any, GvHD toxicity as well as a strong intratumoral homing...
January 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29367468/dna-methylation-signatures-reflect-aging-in-patients-with-nonalcoholic-steatohepatitis
#15
Rohit Loomba, Yevgeniy Gindin, Zhaoshi Jiang, Eric Lawitz, Stephen Caldwell, C Stephen Djedjos, Ren Xu, Chuhan Chung, Robert P Myers, G Mani Subramanian, Zachary Goodman, Michael Charlton, Nezam H Afdhal, Anna Mae Diehl
A DNA methylation (DNAm) signature (the "Horvath clock") has been proposed as a measure of human chronological and biological age. We determined peripheral blood DNAm in patients with nonalcoholic steatohepatitis (NASH) and assessed whether accelerated aging occurs in these patients. DNAm signatures were obtained in patients with biopsy-proven NASH and stage 2-3 fibrosis. The DNAm profile from one test and two validation cohorts served as controls. Age acceleration was calculated as the difference between DNAm age and the predicted age based on the linear model derived from controls...
January 25, 2018: JCI Insight
https://www.readbyqxmd.com/read/29358174/low-density-lipoprotein-uptake-inhibits-the-activation-and-antitumour-functions-of-human-vgamma9vdelta2-t-cells
#16
Neidy Varela Rodrigues, Daniel V Correia, Sofia Mensurado, Sandrina Nobrega-Pereira, Ana deBarros, Fernanda Kyle-Cezar, Andrew Tutt, Adrian C Hayday, Haakan Norell, Bruno Silva-Santos, Sergio Dias
Vgamma9Vdelta2 T cells, the main subset of gamma delta T lymphocytes in human peripheral blood, are endowed with antitumor functions such as cytotoxicity and IFNgamma production. These functions are triggered upon TCR-dependent activation by non-peptidic prenyl pyrophosphates ("phosphoantigens") that are selective agonists of Vgamma9Vdelta2 T cells, and which have been evaluated in clinical studies. Because phosphoantigens have shown inter-individual variation in Vgamma9Vdelta2 T-cell activities, we asked whether metabolic resources, namely lipids such as cholesterol, could affect phosphoantigen-mediated Vgamma9Vdelta2 T-cell activation and function...
January 22, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29338330/joint-influence-of-snps-and-dna-methylation-on-lipids-in-african-americans-from-hypertensive-sibships
#17
Michelle L Wright, Erin B Ware, Jennifer A Smith, Sharon L R Kardia, Jacquelyn Y Taylor
INTRODUCTION: Plasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Some of the observed variability in serum lipid concentrations has been associated with genetic and epigenetic variants among cohorts with European ancestry (EA). Serum lipid levels have also been associated with genetic variants in multiethnic populations...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29298087/quantitative-evaluation-of-mmp-9-and-timp-1-promoter-methylation-in-chronic-periodontitis
#18
Xiting Li, Jiaxuan Lu, Wei Teng, Chuanjiang Zhao, Xiaolei Ye
In this study, we investigated the promoter DNA methylation (DNAm) status of the MMP-9 and TIMP-1 genes in patients with chronic periodontitis to evaluate disease progression. Using pyrosequencing technology, DNAm levels of MMP-9 and TIMP-1 CpG islands were measured in 88 chronic periodontitis patients and 15 healthy controls. We found a positive correlation between methylation levels of MMP-9 CpG islands and the severity of chronic periodontitis. Methylated CpG islands were also closely associated with the duration of chronic periodontitis...
January 3, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29296800/the-number-of-cd56-dim-nk-cells-in-the-graft-has-a-major-impact-on-risk-of-disease-relapse-following-allo-hsct
#19
Luke Maggs, Francesca Kinsella, Y L Tracey Chan, Suzy Eldershaw, Duncan Murray, Jane Nunnick, Joanne Bird, Charles Craddock, Jianmin Zuo, Ram Malladi, Paul Moss
The graft-versus-leukemia (GVL) effect of allogeneic hemopoietic stem cell transplantation (allo-HSCT) is mediated by the donor immune system and acts to decrease the rate of disease relapse. Although studies of posttransplant immune reconstitution have identified correlates of clinical outcome, the number and profile of mature immune cells infused with the stem cell graft is also likely to be an important determinant and has been relatively poorly studied. We characterized immune cells within the stem cell graft of 107 patients who underwent T-cell-depleted allo-HSCT and related this to clinical outcome...
August 22, 2017: Blood Advances
https://www.readbyqxmd.com/read/29273273/utility-of-dna-methylation-to-assess-placental-health
#20
Samantha L Wilson, Wendy P Robinson
DNA methylation (DNAm), a mitotically stable epigenetic mark, can influence as well as reflect gene expression. DNAm has been gaining interest for use as a biomarker for many conditions including placental insufficiency, specifically preeclampsia (PE) and intrauterine growth restriction (IUGR). Additionally, DNAm may retain a "memory" of earlier in utero exposures and hence provide insight into pathogeneses occurring earlier in gestation. This review will discuss the placental DNA methylome, the uses of DNAm to assess placental health, and considerations and limitations to understand in epigenome-wide association studies (EWAS)...
December 14, 2017: Placenta
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