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https://www.readbyqxmd.com/read/27936239/a-broad-spectrum-chemokine-binding-protein-of-bovine-papular-stomatitis-virus-inhibits-neutrophil-and-monocyte-infiltration-in-inflammatory-and-wound-models-of-mouse-skin
#1
Saeed Sharif, Yoshio Nakatani, Lyn Wise, Michael Corbett, Nicola C Real, Gabriella S Stuart, Zabeen Lateef, Kurt Krause, Andrew A Mercer, Stephen B Fleming
Bovine papular stomatitis virus (BPSV) is a Parapoxvirus that induces acute pustular skin lesions in cattle and is transmissible to humans. Previous studies have shown that BPSV encodes a distinctive chemokine-binding protein (CBP). Chemokines are critically involved in the trafficking of immune cells to sites of inflammation and infected tissue, suggesting that the CBP plays a role in immune evasion by preventing immune cells reaching sites of infection. We hypothesised that the BPSV-CBP binds a wide range of inflammatory chemokines particularly those involved in BPSV skin infection, and inhibits the recruitment of immune cells from the blood into inflamed skin...
2016: PloS One
https://www.readbyqxmd.com/read/27935900/-thromboangiitis-obliterans-buerger-s-disease-state-of-the-art
#2
D D Zerbino, E A Zimba, N N Bagry
Thromboangiitis obliterans (Buerger's disease) is systemic vasculitis with predominant development of thrombotic occlusions of small-to-medium diameter arteries of distal portions of both upper and lower limbs. A distinctive feature of Buerger's disease from other vasculitides is the involvement of the venous bed into the pathological process in the form of migrating thrombophlebitis. The disease is encountered more often in young adult males, predominantly tobacco smokers. The clinical pattern is presented by symptoms of increasing insufficiency of blood supply of tissues of extremities...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27935888/-effect-of-angioprotective-therapy-with-bioflavonoids-on-endothelial-dysfunction-in-patients-with-acute-venous-thromboses
#3
A Yu Bryushkov, P V Ershov, N A Sergeeva, V Yu Bogachev
The study was aimed at evaluating a possibility of correcting endothelial dysfunction by means of angioprotective therapy with natural-origin bioflavonoids in patients presenting with acute venous thromboses. Ours was an open comparative prospective study including a total of thirty 34-to-60-year-old patients suffering from lower limb deep vein thrombosis. The patients were subdivided into two groups. The Study Group was composed of 15 patients receiving on the background of anticoagulant therapy with direct thrombin inhibitors (dabigatran etexilate at a daily dose of 300 mg) natural-origin angioprotectors (red grape leaf extract)...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27935884/-use-of-the-multitask-device-while-performing-endarterectomy-from-iliac-arteries
#4
I P Mikhailov, G A Isaev, L S Kokov, I M Gol'dina
AIM: The study was aimed at assessing efficacy of using the "MultiTASK" device manufactured by the Le Maitre Company while performing extended endarterectomy from iliac arteries in patients presenting with multilevel atherosclerotic lesions of the arterial bed and chronic ischaemia of lower extremities. PATIENTS AND METHODS: We analysed the outcomes of surgical management of a total of 37 patients presenting with multilevel atherosclerotic lesions of the common and external iliac arteries and arteries below the inguinal ligament over the period from 2012 to 2015 at the Department of Emergency Vascular Surgery of the Scientific Research Institute of Emergency Ambulance Care named after N...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27935789/the-development-and-validation-of-the-mood-based-indoor-tanning-scale
#5
Nick Carcioppolo, Yixin Chen, Kevin K John, Andrea Martinez Gonzalez, Andy J King, Susan E Morgan, Shasa Hu
OBJECTIVES: Research indicates that mood-based motivations may be an important predictor of indoor tanning bed use and may be related to indoor tanning dependence. Problematically, little research has been conducted to develop a psychometric measure of mood-based tanning motivations. The current study seeks to develop and validate the moodbased indoor tanning scale (MITS). METHODS: Two studies were conducted to identify and verify the MITS factor structure as well as assess construct validity...
January 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/27935061/autophagy-in-uv-damage-response
#6
Ashley Sample, Yu-Ying He
UV radiation exposure from sunlight and artificial tanning beds is the major risk factor for the development of skin cancer and skin photoaging. UV-induced skin damage can trigger a cascade of DNA damage response signaling pathways, including cell cycle arrest, DNA repair, and, if damage is irreparable, apoptosis. Compensatory proliferation replaces the apoptotic cells to maintain skin barrier integrity. Disruption of these processes can be exploited to promote carcinogenesis by allowing the survival and proliferation of damaged cells...
December 9, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27934934/long-duration-of-ground-motion-in-the-paradigmatic-valley-of-mexico
#7
V M Cruz-Atienza, J Tago, J D Sanabria-Gómez, E Chaljub, V Etienne, J Virieux, L Quintanar
Built-up on top of ancient lake deposits, Mexico City experiences some of the largest seismic site effects worldwide. Besides the extreme amplification of seismic waves, duration of intense ground motion from large subduction earthquakes exceeds three minutes in the lake-bed zone of the basin, where hundreds of buildings collapsed or were seriously damaged during the magnitude 8.0 Michoacán earthquake in 1985. Different mechanisms contribute to the long lasting motions, such as the regional dispersion and multiple-scattering of the incoming wavefield from the coast, more than 300 km away the city...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934258/capturing-lithium-from-wastewater-using-a-fixed-bed-packed-with-3-d-mno2-ion-cages
#8
Xubiao Luo, Kai Zhang, Jinming Luo, Shenglian Luo, John Crittenden
3-D MnO2 ion cages (CMO) were fabricated and shown to have a high capacity for lithium removal from wastewater. CMO had a maximum Li(I) adsorption capacity of 56.87 mg/g, which is 1.38 times greater than the highest reported value (41.36 mg/g). X-ray photoelectron spectroscopy indicated that the stability of the -Mn-O-Mn-O- skeleton played an essential role in Li adsorption. The lattice clearance had a high charge density, forming a strong electrostatic field. The Dubinin-Ashtakhov (DA) site energy distribution model based on Polanyi theory described the linear increase of Li adsorption capacity (Q0) with increasing temperature (Q0 = k3 × Em + d3 = k3 × (a × T) + d3)...
December 6, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27933555/pharmacist-s-comprehensive-geriatric-assessment-introduction-and-evaluation-at-elderly-patient-admission
#9
Faiza Rhalimi, Mounir Rhalimi, Alain Rauss
BACKGROUND: The role of the clinical pharmacist within the healthcare system remains unclear. OBJECTIVE: Our objective was to describe a pharmacist's comprehensive geriatric assessment (pCGA) at admission of elderly patients and to assess its relevance in terms of medication compliance and pharmacist interventions (PIs). METHODS: We conducted a prospective interventional study over 29 months in a 34-bed medical/rehabilitation geriatric ward in a French geriatric hospital...
December 8, 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27933514/changes-in-cardiac-repolarisation-during-spontaneous-nocturnal-hypoglycaemia-in-subjects-with-type-1-diabetes-a-preliminary-report
#10
Minna L Koivikko, Tuomas Kenttä, Pasi I Salmela, Heikki V Huikuri, Juha S Perkiömäki
AIMS: Experimental studies have revealed that hypoglycaemia can result in morphological changes in electrocardiographic repolarisation in subjects with type 1 diabetes. However, the influence of spontaneous nocturnal hypoglycaemia on repolarisation morphology in a 'real life' situation is not clear. METHODS: Adults with type 1 diabetes (n = 11) underwent continuous glucose monitoring with a subcutaneous sensor and digital 12-lead ECG recording for three nights...
December 8, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27932683/survival-of-bacteria-of-laboratory-animal-origin-on-cage-bedding-and-inactivation-by-hydrogen-peroxide-vapour
#11
Laurentiu Benga, W Peter M Benten, Eva Engelhardt, Christina Gougoula, Roland Schulze-Röbbecke, Martin Sager
This study aims to determine the ability of laboratory animal bacteria to resist desiccation and inactivation by hydrogen peroxide vapour (HPV) on paper bedding pieces. Bedding pieces were saturated with bacterial suspensions in water or 2% (w/v) bovine serum albumin (BSA) in water, and held in a mouse facility. Viable counts showed variable survival rates over time for the bacterial species used ([Pasteurella] pneumotropica, Muribacter muris, Pseudomonas aeruginosa, Acinetobacter redioresistens, Escherichia coli, Klebsiella oxytoca, Bordetella bronchiseptica, Bordetella hinzii, Enterococcus faecalis, β-haemolytic Streptococcus spp...
December 8, 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27932674/metabolic-adaptations-in-skeletal-muscle-after-84-days-bed-rest-with-and-without-concurrent-flywheel-resistance-exercise
#12
José Maria Irimia, Mario Guerrero, Paula Rodriguez-Miguelez, Joan Aureli Cadefau, Per A Tesch, Roser Cussó, Rodrigo Fernandez-Gonzalo
As metabolic changes in human skeletal muscle after long-term (simulated) spaceflight are not well understood, this study examined the effects of long-term microgravity, with and without concurrent resistance exercise on skeletal muscle oxidative and glycolytic capacity. Twenty-one men were subjected to 84 days head-down tilt bed rest with (BRE; n=9) or without (BR; n=12) concurrent flywheel resistance exercise. Activity and gene expression of glycogen synthase, glycogen phosphorylase (GPh), hexokinase, phosphofructokinase-1 (PFK-1) and citrate synthase (CS), as well as gene expression of succinate dehydrogenase (SDH), vascular endothelial growth factor (VEFG), peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1α) and myostatin, were analysed in samples from m...
December 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27932204/total-renal-denervation-reduces-sympathoexcitation-to-different-target-organs-in-a-model-of-chronic-kidney-disease
#13
REVIEW
Glaucia L Veiga, Erika E Nishi, Heder F Estrela, Gisele S Lincevicius, Guiomar N Gomes, Alex Y Simões Sato, Ruy R Campos, Cássia T Bergamaschi
It is known that increased sympathetic nerve activity in chronic kidney disease (CKD) progressively worsens kidney function and hypertension. We tested the hypothesis that total renal denervation contributes to reduce sympathetic activation to different beds and improves renal function in 5/6 nephrectomy model of CKD in male Wistar rats. After eight weeks of 5/6 nephrectomy surgery there was an increase in mean arterial pressure (CKD 179±22mmHg, n=6 vs. control animals 108±9; p<0.05, n=6) with no changes in heart rate (HR)...
December 1, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27931870/effects-of-early-mobilisation-in-patients-after-cardiac-surgery-a-systematic-review
#14
REVIEW
P M Ramos Dos Santos, N Aquaroni Ricci, É Aparecida Bordignon Suster, D de Moraes Paisani, L Dias Chiavegato
BACKGROUND: Early mobilisation is prescribed after cardiac surgery to prevent postoperative complications, decrease length of hospital stay, and augment return to daily activities. OBJECTIVE: To evaluate the evidence for the effects of early mobilisation in patients after cardiac surgery on length of hospital stay, functional capacity and postoperative complications. DATA SOURCES: The data sources used were Medline, Embase, CINAHL, PEDro, Web of Science and Cochrane Central Register of Controlled Trials...
September 14, 2016: Physiotherapy
https://www.readbyqxmd.com/read/27931564/taking-care-of-relationships-in-the-intensive-care-unit-positive-impact-on-family-consent-for-organ-donation
#15
M G Bocci, C D'Alò, R Barelli, S Inguscio, A Prestifilippo, S Di Paolo, S Lochi, M Fanfarillo, D L Grieco, R Maviglia, A Caricato, G Mistraletti, S Pulitanò, M Antonelli, C Sandroni
BACKGROUND: Organ donation refusal from relatives of potential donors with brain death significantly reduces organ availability. The need for organ donation has increased over time, but the shortage of available donors is the major limiting factor in transplantation. We analyzed the impact of a new systematic communication approach between medical staff and patients' relatives on the rate of consent to organ donation. METHODS: The study was conducted as a single-center, non-randomized, controlled, before-and-after study at an 18-bed intensive care unit (ICU) of a university hospital...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931317/influence-of-rack-design-and-disease-prevalence-on-detection-of-rodent-pathogens-in-exhaust-debris-samples-from-individually-ventilated-caging-systems
#16
Beth A Bauer, Cynthia Besch-Williford, Robert S Livingston, Marcus J Crim, Lela K Riley, Matthew H Myles
Sampling of bedding debris within the exhaust systems of ventilated racks may be a mechanism for detecting murine pathogens in colony animals. This study examined the effectiveness of detecting pathogens by PCR analysis of exhaust debris samples collected from ventilated racks of 2 different rack designs, one with unfiltered air flow from within the cage to the air-exhaust pathway, and the other had a filter between the cage and the air-exhaust pathway. For 12 wk, racks were populated with either 1 or 5 cages of mice (3 mice per cage) infected with one of the following pathogens: mouse norovirus (MNV), mouse parvovirus (MPV), mouse hepatitis virus (MHV), Helicobacter spp...
November 2016: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/27931316/exhaust-air-dust-monitoring-is-superior-to-soiled-bedding-sentinels-for-the-detection-of-pasteurella-pneumotropica-in-individually-ventilated-cage-systems
#17
Manuel Miller, Brbel Ritter, Julia Zorn, Markus Brielmeier
Reliable detection of unwanted organisms is essential for meaningful health monitoring in experimental animal facilities. Currently, most rodents are housed in IVC systems, which prevent the aerogenic transmission of pathogens between cages. Typically soiled-bedding sentinels (SBS) exposed to soiled bedding collected from a population of animals within an IVC rack are tested as representatives, but infectious agents often go undetected due to inefficient transmission. Pasteurellaceae are among the most prevalent bacterial pathogens isolated from experimental mice, and the failure of SBS to detect these bacteria is well established...
November 2016: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/27930995/predictors-of-clinicians-underuse-of-daily-sedation-interruption-and-sedation-scales
#18
B Sneyers, S Henrard, P F Laterre, M M Perreault, C Beguin, D Wouters, N Speybroeck, A Spinewine
PURPOSE: The purpose of the study is to identify predictors of underuse of sedation scales and daily sedation interruption (DSI). METHODS: We surveyed all physicians and seven nurses in every Belgian intensive care unit (ICU), addressing practices and perceptions on guideline recommendations. Underuse was defined for sedation scales as use less than 3× per day and for DSI as never using it. Classification trees and logistic regressions identified predictors of underuse...
August 11, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27930679/reconstruction-of-the-foot-and-ankle-using-pedicled-or-free-flaps-perioperative-flap-survival-analysis
#19
Xiucun Li, Jianli Cui, Suraj Maharjan, Laijin Lu, Xu Gong
OBJECTIVE: The purpose of this study is to determine the correlation between non-technical risk factors and the perioperative flap survival rate and to evaluate the choice of skin flap for the reconstruction of foot and ankle. METHODS: This was a clinical retrospective study. Nine variables were identified. The Kaplan-Meier method coupled with a log-rank test and a Cox regression model was used to predict the risk factors that influence the perioperative flap survival rate...
2016: PloS One
https://www.readbyqxmd.com/read/27930384/the-endothelial-mineralocorticoid-receptor-mediator-of-the-switch-from-vascular-health-to-disease
#20
Ana P Davel, Imran J Anwar, Iris Z Jaffe
PURPOSE OF REVIEW: Endothelial dysfunction is an early feature of vascular disease induced by cardiovascular risk factors (CRFs). In growing populations with obesity, diabetes, hypertension, and heart failure, mineralocorticoid receptor antagonism improves endothelial function. This review summarizes recent advances in our understanding of the specific role of endothelial cell mineralocorticoid receptor in vascular function in health and disease. RECENT FINDINGS: Using transgenic mice with mineralocorticoid receptor expression specifically modulated in endothelial cells, recent studies support the emerging concept that while endothelial cell mineralocorticoid receptor may be protective in health, in the presence of CRFs, endothelial cell mineralocorticoid receptor activity contributes to endothelial dysfunction and progression of vascular disease...
December 7, 2016: Current Opinion in Nephrology and Hypertension
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