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https://www.readbyqxmd.com/read/29682995/efficacy-and-safety-of-the-combination-of-isosorbide-dinitrate-spray-and-chitosan-gel-for-the-treatment-of-diabetic-foot-ulcers-a-double-blind-randomized-clinical-trial
#1
Sylvia Elena Totsuka Sutto, Yunuen Itzet Rodríguez Roldan, Ernesto German Cardona Muñoz, Teresa Arcelia Garcia Cobian, Sara Pascoe Gonzalez, Abril Martínez Rizo, Miriam Mendez Del Villar, Leonel García Benavides
AIM: To evaluate whether a combination of isosorbide dinitrate spray and chitosan gel (10%) topically applied can have additive benefits for management of diabetic foot ulcers. METHODS: In a randomized, placebo-controlled, double-blinded clinical trial, 68 patients were divided into four groups: Group 1: treated with chitosan gel; Group 2: isosorbide dinitrate spray; Group 3: combination of isosorbide dinitrate spray and chitosan gel; Group 4: placebo. RESULTS: Histological analyses showed a significant regeneration in all groups ( p < 0...
April 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29680773/changes-in-the-hippocampal-and-peripheral-phospholipid-profiles-are-associated-with-neurodegeneration-hallmarks-in-a-long-term-global-cerebral-ischemia-model-attenuation-by-linalool
#2
Angélica Maria Sabogal-Guáqueta, Rafael Posada-Duque, Natalie Charlotte Cortes, Julian D Arias-Londoño, Gloria Patricia Cardona-Gómez
Phospholipid alterations in the brain are associated with progressive neurodegeneration and cognitive impairment after acute and chronic injuries. Various types of treatments have been evaluated for their abilities to block the progression of the impairment, but effective treatments targeting long-term post-stroke alterations are not available. In this study, we analyzed changes in the central and peripheral phospholipid profiles in ischemic rats and determined whether a protective monoterpene, Linalool, could modify them...
April 19, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29679699/amaryllidaceae-alkaloids-as-agents-with-protective-effects-against-oxidative-neural-cell-injury
#3
Natalie Cortes, Carol Castañeda, Edison H Osorio, Gloria Patricia Cardona-Gomez, Edison Osorio
AIMS: Determine a relationship between the neuroprotective activity and the antioxidant capacity of the Amaryllidaceae alkaloids in a model of Glu excitotoxicity in rat cortical neurons. MATERIALS AND METHODS: Was evaluated several alkaloidal fractions isolated from Amaryllidaceae species, a family known to contain neuroprotective alkaloids, in a model of Glu excitotoxicity in rat cortical neurons. In addition, several mechanisms of antioxidant activity were used, and a theoretical study of the antioxidants was performed...
April 18, 2018: Life Sciences
https://www.readbyqxmd.com/read/29671387/positioning-europe-for-the-epitranscriptomics-challenge
#4
Michael Jantsch, Alessandro Quattrone, Mary O'Connell, Mark Helm, Michaela Frye, Manuel Macias-Gonzales, Marie Ohman, Stefan Ameres, Luc Willems, Francois Fuks, Anastasis Oulas, Stepanka Vanacova, Henrik Nielsen, Cecile Bousquet-Antonelli, Yuri Motorin, Jean-Yves Roignant, Nikolaos Balatsos, Andras Dinnyes, Pavel Baranov, Vincent Kelly, Ayelet Lamm, Gideon Rechavi, Mattia Pelizzola, Janis Liepins, Irina Holodnuka Kholodnyuk, Vanessa Zammit, Duncan Ayers, Finn Drablos, John Arne Dahl, Janusz Bujnicki, Carmen Jeronimo, Raquel Almeida, Monica Neagu, Marieta Costache, Jasna Bankovic, Bojana Banovic, Jan Kyselovic, Luis Miguel Valor, Stefan Selbert, Pinar Pir, Turan Demircan, Victoria Cowling, Matthias Schäfer, Walter Rossmanith, Denis Lafontaine, Alexandre David, Clement Carre, Frank Lyko, Raffael Schaffrath, Schraga Schwartz, Andre Verdel, Arne Klungland, Elzbieta Purta, Gordana Timotijevic, Fernando Cardona, Alberto Davalos, Ester Ballana, Donal O Carroll, Jernej Ule, Rupert Fray
The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research...
April 19, 2018: RNA Biology
https://www.readbyqxmd.com/read/29668860/alectinib-versus-chemotherapy-in-crizotinib-pretreated-anaplastic-lymphoma-kinase-alk-positive-non-small-cell-lung-cancer-results-from-the-phase-iii-alur-study
#5
S Novello, J Mazières, I-J Oh, J de Castro, M R Migliorino, Å Helland, R Dziadziuszko, F Griesinger, A Kotb, A Zeaiter, A Cardona, B Balas, H K Johannsdottir, A Das-Gupta, J Wolf
Background: This is the first trial to directly compare efficacy and safety of alectinib versus standard chemotherapy in advanced/metastatic anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC) patients who have progressed on, or were intolerant to, crizotinib. Patients and methods: ALUR (MO29750; NCT02604342) was a randomized, multicenter, open-label, phase III trial of alectinib versus chemotherapy in advanced/metastatic anaplastic lymphoma kinase (ALK)-positive NSCLC patients previously treated with platinum-based doublet chemotherapy and crizotinib...
April 14, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29668489/intravenous-lipid-emulsion-and-ethanol-for-sodium-fluoroacetate-poisoning
#6
Claudia Lucía Arroyave Hoyos, Maria Alejandra Cañas Galvis, David Ospina Estrada, Maria Camila Henao Solarte, Salomé Lopera Cardona
No abstract text is available yet for this article.
April 11, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29668137/costo-efectividad-de-dos-esquemas-de-prevenci%C3%A3-n-de-la-infecci%C3%A3-n-por-citomegalovirus-en-pacientes-con-trasplante-renal-y-riesgo-intermedio-en-colombia
#7
Kateir Contreras, María José Vargas, Paola García, Camilo A González, Patricia Rodríguez, Camilo Castañeda-Cardona, Margarita Otálora-Esteban, Diego Rosselli
Introducción. El citomegalovirus es la causa más frecuente de infección en pacientes con trasplante renal. Existen dos estrategias de similar efectividad para prevenirlo: la profilaxis universal con valganciclovir durante 90 días o el tratamiento anticipado verificando la carga viral semanal y aplicándolo solo si esta es positiva.Objetivo. Determinar cuál de estas dos estrategias sería más costo-efectiva en pacientes de riesgo intermedio en Colombia.Materiales y métodos. Se diseñó un árbol de decisiones bajo la perspectiva del tercer pagador considerando únicamente los costos médicos directos en pesos colombianos (COP) del 2014 durante un periodo de un año en una población de pacientes con riesgo intermedio para citomegalovirus (donante positivo y receptor positivo, o donante negativo y receptor positivo)...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29665804/immediate-implant-replacement-with-diep-flap-a-single-stage-salvage-option-in-failed-implant-based-breast-reconstruction
#8
Miguel De La Parra Marquez, Ricardo Fernandez-Riera, Hector Vela Cardona, Jesus María Rangel Flores
BACKGROUND: Implant-based immediate breast reconstruction after skin-sparing mastectomy has shown a significant improvement in patients' quality of life, making the procedure steadily more popular year after year. However, this technique has a high morbidity rate, including skin necrosis and implant exposure. METHODS: A retrospective review of a prospectively held database for autologous breast reconstruction in our institution of the last 5 years found eight cases with exposed implants after nipple-sparing mastectomy and immediate reconstruction...
April 17, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29660331/biophysical-characterization-of-actin-bundles-generated-by-the-chlamydia-trachomatis-tarp-effector
#9
Susmita Ghosh, Jinho Park, Mitchell Thomas, Edgar Cruz, Omar Cardona, Hyeran Kang, Travis Jewett
Chlamydia trachomatis entry into host cells is mediated by pathogen-directed remodeling of the actin cytoskeleton. The chlamydial type III secreted effector, translocated actin recruiting phosphoprotein (Tarp), has been implicated in the recruitment of actin to the site of internalization. Tarp harbors G-actin binding and proline rich domains required for Tarp-mediated actin nucleation as well as unique F-actin binding domains implicated in the formation of actin bundles. Little is known about the mechanical properties of actin bundles generated by Tarp or the mechanism by which Tarp mediates actin bundle formation...
April 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29659755/mechanical-thrombectomy-for-patients-with-infective-endocarditis-and-ischemic-large-vessel-stroke
#10
Guillermo Cuervo, Queralt Caballero, Alexander Rombauts, Immaculada Grau, Carmen Ardanuy, Pere Cardona, Y Jordi CarratalÀ
No abstract text is available yet for this article.
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29656755/the-burden-of-lung-cancer-in-latin-america-and-challenges-in-the-access-to-genomic-profiling-immunotherapy-and-targeted-treatments
#11
REVIEW
Luis E Raez, Andrés F Cardona, Edgardo S Santos, Heath Catoe, Christian Rolfo, Gilberto Lopes, Carlos Barrios, Luis A Mas, Carlos Vallejos, Zyanya Lucia Zatarain-Barrón, Christian Caglevic, Oscar Arrieta
Lung cancer is a public health problem worldwide and Latin America (LATAM) cannot escape this reality. This malignant disease has not only a high prevalence in the region, but is also the main cause of cancer related deaths, and in other emerging countries, the incidence rates are still on the rise. Interestingly in most LATAM countries, lung cancer mortality has been decreasing in men but not in women, reflecting smoking patterns in countries such as Chile, Bolivia, and Brazil. Despite the fact that these issues are well known to government agencies, physicians and patients in the region, current efforts still fall behind those needed in order to face this problem of epidemic proportions...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29627640/genetic-variants-structural-and-functional-changes-of-myelin-protein-zero-and-mannose-binding-lectin-2-protein-involved-in-immune-response-and-its-allelic-transmission-in-families-of-patients-with-leprosy-in-colombia
#12
Viviana Cardona-Pemberthy, Michelle Rendón, Juan Camilo Beltrán, Alejandro Soto-Ospina, Amalia Muñoz-Gomez, Pedronel Araque-Marín, Mauricio Corredor, Gabriel Bedoya, Nora Cardona-Castrod
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Genetic factors associated with immune response contribute to infection development and disease. M. leprae has the capacity to invade Schwann cells in the peripheral nervous system and cause neuropathy. However, while the responsible molecular mechanisms remain to be fully unveiled, they have begun being elucidated. We studied genetic variants Myelin Protein Zero (MPZ), a major structural component of the myelin sheath, and Mannose Binding Lectin 2 (MBL2), a protein involved in immune response, in 112 family groups of 114 leprosy patients using PCR-RFLP, aiming to calculate the association and allelic transmission of variants associated in first, second and third-degree relatives...
April 5, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29626328/techno-economic-and-environmental-assessment-of-biogas-production-from-banana-peel-musa-paradisiaca-in-a-biorefinery-concept
#13
Jimmy Anderson Martínez-Ruano, Ashley Sthefanía Caballero-Galván, Daissy Lorena Restrepo-Serna, Carlos Ariel Cardona
Two scenarios for the biogas production using Banana Peel as raw material were evaluated. The first scenario involves the stand-alone production of biogas and the second scenario includes the biogas production together with other products under biorefinery concept. In both scenarios, the influence of the production scale on the process economy was assessed and feasibility limits were defined. For this purpose, the mass and energy balances were established using the software Aspen Plus along with kinetic models reported in the literature...
April 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29625981/a-consistent-and-predictable-commercial-broiler-chicken-bacterial-microbiota-in-antibiotic-free-production-displays-strong-correlations-with-performance
#14
Timothy J Johnson, Bonnie P Youmans, Sally Noll, Carol Cardona, Nicholas P Evans, T Peter Karnezos, John M Ngunjiri, Michael C Abundo, Chang-Won Lee
Defining the baseline bacterial microbiome is critical towards understanding its relationship with health and disease. In broiler chickens, the core microbiome and its possible relationships with health and disease have been difficult to define due to high variability between birds and flocks. Presented are data from a large, comprehensive microbiota-based study in commercial broilers. The primary goals of this study included understanding what constitutes the core bacterial microbiota in the broiler gastrointestinal, respiratory, and barn environments; how these core players change across age, geography, and time; and which bacterial taxa correlate with enhanced bird performance in antibiotic-free flocks...
April 6, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29617656/impaired-spermatogenesis-muscle-and-erythrocyte-function-in-u12-intron-splicing-defective-zrsr1-mutant-mice
#15
Keiko Horiuchi, Serafín Perez-Cerezales, Panagiotis Papasaikas, Priscila Ramos-Ibeas, Angela Patricia López-Cardona, Ricardo Laguna-Barraza, Noelia Fonseca Balvís, Eva Pericuesta, Raul Fernández-González, Benjamín Planells, Alberto Viera, Jose Angel Suja, Pablo Juan Ross, Francisco Alén, Laura Orio, Fernando Rodriguez de Fonseca, Belén Pintado, Juan Valcárcel, Alfonso Gutiérrez-Adán
The U2AF35-like ZRSR1 has been implicated in the recognition of 3' splice site during spliceosome assembly, but ZRSR1 knockout mice do not show abnormal phenotypes. To analyze ZRSR1 function and its precise role in RNA splicing, we generated ZRSR1 mutant mice containing truncating mutations within its RNA-recognition motif. Homozygous mutant mice exhibited severe defects in erythrocytes, muscle stretch, and spermatogenesis, along with germ cell sloughing and apoptosis, ultimately leading to azoospermia and male sterility...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29608188/the-reality-of-complexity-concomitant-genomic-alterations-in-patients-with-egfr-mutations
#16
EDITORIAL
Andrés F Cardona, Zyanya Lucia Zatarain-Barrón, Leonardo Rojas, Oscar Arrieta
No abstract text is available yet for this article.
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29604300/face-memory-and-face-recognition-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-systematic-review
#17
REVIEW
Maria Romani, Miriam Vigliante, Noemi Faedda, Serena Rossetti, Lina Pezzuti, Vincenzo Guidetti, Francesco Cardona
This review focuses on facial recognition abilities in children and adolescents with attention deficit hyperactivity disorder (ADHD). A systematic review, using PRISMA guidelines, was conducted to identify original articles published prior to May 2017 pertaining to memory, face recognition, affect recognition, facial expression recognition and recall of faces in children and adolescents with ADHD. The qualitative synthesis based on different studies shows a particular focus of the research on facial affect recognition without paying similar attention to the structural encoding of facial recognition...
March 28, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29596787/gradually-transformed-parry-romberg-syndrome
#18
Carlos Felipe Matute, Felipe Jose Matute, Daniel Cardona, Daniel G Federman
No abstract text is available yet for this article.
March 26, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29596496/radiogenomics-analysis-identifies-correlations-of-digital-mammography-with-clinical-molecular-signatures-in-breast-cancer
#19
Jose-Gerardo Tamez-Peña, Juan-Andrés Rodriguez-Rojas, Hugo Gomez-Rueda, Jose-Maria Celaya-Padilla, Roxana-Alicia Rivera-Prieto, Rebeca Palacios-Corona, Margarita Garza-Montemayor, Servando Cardona-Huerta, Victor Treviño
In breast cancer, well-known gene expression subtypes have been related to a specific clinical outcome. However, their impact on the breast tissue phenotype has been poorly studied. Here, we investigate the association of imaging data of tumors to gene expression signatures from 71 patients with breast cancer that underwent pre-treatment digital mammograms and tumor biopsies. From digital mammograms, a semi-automated radiogenomics analysis generated 1,078 features describing the shape, signal distribution, and texture of tumors along their contralateral image used as control...
2018: PloS One
https://www.readbyqxmd.com/read/29589024/vanadyl-dithiolate-single-molecule-transistors-the-next-spintronic-frontier
#20
S Cardona-Serra, A Gaita-Ariño
On the road towards quantum devices, chemistry can offer elementary pieces with a built-in function, like [TbPc2]- which functions as a molecular transistor for nuclear spin detection. We argue that a large class of molecules have similar potential. In particular, we review the recent progress regarding highly coherent spin qubits based on vanadium dithiolate complexes. We propose their use as single molecule transistors to read and control a triple nuclear spin qubit, which could enable a low-current nuclear spin detection scheme by means of a spin valve effect...
March 28, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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