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https://www.readbyqxmd.com/read/29452860/pancreaticoduodenectomy-in-the-surgical-management-of-primary-retroperitoneal-sarcoma
#1
William W Tseng, Denice D Tsao-Wei, Dario Callegaro, Giovanni Grignani, Lorenzo D'Ambrosio, Sylvie Bonvalot, Cecilia G Ethun, Kenneth Cardona, John T Mullen, Robert J Canter, John E Mullinax, Ricardo J Gonzalez, Frits van Coevorden, Markus Albertsmeier, Kiran K Dhanireddy, Salvatore L Renne, Alessandro Gronchi
BACKGROUND: In retroperitoneal sarcoma (RPS), the optimal extent of resection must balance adequate disease control with potential for morbidity. We sought to study the frequency and outcomes after a Whipple procedure or pancreaticoduodenectomy (PD) in patients undergoing resection for primary RPS. METHODS: Participating referral centers within the Trans-Atlantic Retroperitoneal Sarcoma Working Group provided retrospective data from January 2007 to December 2016 for patients with primary RPS who underwent PD along with the total number of consecutive resections done during the same time period...
February 5, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29446469/clinical-trials-in-allergen-immunotherapy-current-concepts-and-future-needs
#2
REVIEW
O Pfaar, M Alvaro, V Cardona, E Hamelmann, R Mösges, J Kleine-Tebbe
Allergen immunotherapy (AIT) is a safe, effective treatment for allergic rhinoconjunctivitis and allergic asthma. However, AIT's clinical effect is still contested - primarily due to heterogeneity in clinical trial designs, study populations, therapeutic formulations and efficacy criteria. After discussing current concepts and unmet needs, an international panel of experts made several recommendations: (i) explore and validate definitions for [clinical] responders in AIT-trials; (ii) use of well-documented, standardized provocation tests prior to inclusion of subjects with relevant diseases in AIT trials; (iii) monitoring neo-sensitizations and occurrence of new allergy in extended AIT trials, and exclusion of polyallergic participants; (iv) validation of allergen exposure chambers with regard to natural exposure; (v) in studies of seasonal allergies, focus on peak exposure but also consider organising two parallel, geographically distinct but otherwise identical trials; (vi) discuss adaptive trial designs with the regulatory authorities; (vii) use e-health and m-health technologies to capture more information on individual exposure to allergens; (viii) initiate research on potential psychological, biochemical, immune, neural and even genomic markers of the placebo response; (ix) identify trial designs and primary endpoints that will give children with allergies easier, faster access to AIT formulations; and (x) promote and apply standardized methods for reporting systemic and local adverse events...
February 15, 2018: Allergy
https://www.readbyqxmd.com/read/29445028/evaluation-of-treatment-patterns-and-survival-outcomes-in-elderly-pancreatic-cancer-patients-a-surveillance-epidemiology-and-end-results-medicare-analysis
#3
Walid L Shaib, Jeb S Jones, Michael Goodman, Juan M Sarmiento, Shishir K Maithel, Kenneth Cardona, Sujata Kane, Christina Wu, Olatunji B Alese, Bassel F El-Rayes
BACKGROUND: Management of pancreatic cancer (PC) in elderly patients is unknown; clinical trials exclude patients with comorbidities and those of extreme age. This study evaluated treatment patterns and survival outcomes in elderly PC patients using linked Surveillance, Epidemiology, and End Results (SEER) and Medicare data. MATERIALS AND METHODS: Histology codes 8140, 8500, 8010, 8560, 8490, 8000, 8260, 8255, 8261, 8263, 8020, 8050, 8141, 8144, 8210, 8211, or 8262 in Medicare Parts A and B were identified...
February 14, 2018: Oncologist
https://www.readbyqxmd.com/read/29444131/chromatin-immunoprecipitation-improvements-for-the-processing-of-small-frozen-pieces-of-adipose-tissue
#4
Daniel Castellano-Castillo, Pierre-Damien Denechaud, Isabel Moreno-Indias, Francisco Tinahones, Lluis Fajas, María Isabel Queipo-Ortuño, Fernando Cardona
Chromatin immunoprecipitation (ChIP) has gained importance to identify links between the genome and the proteome. Adipose tissue has emerged as an active tissue, which secretes a wide range of molecules that have been related to metabolic and obesity-related disorders, such as diabetes, cardiovascular failure, metabolic syndrome, or cancer. In turn, epigenetics has raised the importance in discerning the possible relationship between metabolic disorders, lifestyle and environment. However, ChIP application in human adipose tissue is limited by several factors, such as sample size, frozen sample availability, high lipid content and cellular composition of the tissue...
2018: PloS One
https://www.readbyqxmd.com/read/29435454/garbage-management-an-important-risk-factor-for-hpai-virus-infection-in-commercial-poultry-flocks
#5
Emily Walz, Eric Linskens, Jamie Umber, Marie Rene Culhane, David Halvorson, Francesca Contadini, Carol Cardona
Garbage management represents a potential pathway of HPAI-virus infection for commercial poultry operations as multiple poultry premises may share a common trash collection service provider, trash collection site (e.g., shared dumpster for multiple premises) or disposal site (e.g., landfill). The types of potentially infectious or contaminated material disposed of in the garbage has not been previously described but is suspected to vary by poultry industry sector. A survey of representatives from the broiler, turkey, and layer sectors in the United States revealed that many potentially contaminated or infectious items are routinely disposed of in the trash on commercial poultry premises...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29433983/common-co-activation-of-axl-and-cdcp1-in-egfr-mutation-positive-non-smallcell-lung-cancer-associated-with-poor-prognosis
#6
Niki Karachaliou, Imane Chaib, Andres Felipe Cardona, Jordi Berenguer, Jillian Wilhelmina Paulina Bracht, Jie Yang, Xueting Cai, Zhigang Wang, Chunping Hu, Ana Drozdowskyj, Carles Codony Servat, Jordi Codony Servat, Masaoki Ito, Ilaria Attili, Erika Aldeguer, Ana Gimenez Capitan, July Rodriguez, Leonardo Rojas, Santiago Viteri, Miguel Angel Molina-Vila, Sai-Hong Ignatius Ou, Morihito Okada, Tony S Mok, Trever G Bivona, Mayumi Ono, Jean Cui, Santiago Ramón Y Cajal, Peng Cao, Rafael Rosell
Epidermal growth factor receptor (EGFR)-mutation-positive non-smallcell lung cancer (NSCLC) is incurable, despite high rates of response to EGFR tyrosine kinase inhibitors (TKIs). We investigated receptor tyrosine kinases (RTKs), Src family kinases and focal adhesion kinase (FAK) as genetic modifiers of innate resistance in EGFR-mutation-positive NSCLC. We performed gene expression analysis in two cohorts (Cohort 1 and Cohort 2) of EGFR-mutation-positive NSCLC patients treated with EGFR TKI. We evaluated the efficacy of gefitinib or osimertinib with the Src/FAK/Janus kinase 2 (JAK2) inhibitor, TPX0005 in vitro and in vivo...
February 5, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29433384/region-specific-knock-out-reveals-distinct-roles-of-chromatin-modifiers-in-adult-neurogenic-niches
#7
Christopher T Rhodes, Giulia Zunino, Shu-Wei Angela Huang, Sandra M Cardona, Astrid E Cardona, Mitchel S Berger, Vance P Lemmon, Chin-Hsing Annie Lin
Histone methyltransferases (HMTs) are present in heterogeneous cell populations within the adult brain including neurogenic niches. Yet the question remains whether loss of HMTs and the resulting changes in histone methylation alter cell fate in a region-specific manner. We utilized stereotaxic injection of Cre recombinant protein into the adult neurogenic niches, the subventricular zone (SVZ) adjacent to the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus. We confirmed that Cre protein was enzymatically active in vivo and recombination events were restricted to the vicinity of injection areas...
February 13, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29432131/t-wave-abnormality-as-electrocardiographic-signature-of-myocardial-edema-in-non-st-elevation-acute-coronary-syndromes
#8
Andrea Cardona, Karolina M Zareba, Haikady N Nagaraja, Stephen F Schaal, Orlando P Simonetti, Giuseppe Ambrosio, Subha V Raman
BACKGROUND: T-wave abnormalities are common during the acute phase of non-ST-segment elevation acute coronary syndromes, but mechanisms underlying their occurrence are unclear. We hypothesized that T-wave abnormalities in the presentation of non-ST-segment elevation acute coronary syndromes correspond to the presence of myocardial edema. METHODS AND RESULTS: Secondary analysis of a previously enrolled prospective cohort of patients presenting with non-ST-segment elevation acute coronary syndromes was conducted...
January 26, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29430403/adverse-events-in-critical-care-search-and-active-detection-through-the-trigger-tool
#9
Francisco J Molina, Paula T Rivera, Alejandro Cardona, Diana C Restrepo, Oralia Monroy, Daniel Rodas, Juan G Barrientos
AIM: To investigate the incidence of disadvantageous events by using the Global Trigger Tool in an intensive care unit (ICU). METHODS: A retrospective descriptive study was performed in a 12-bed university ICU in the city of Medellin, Colombia. Clinical charts of hospitalized patients were reviewed, between January 1 and December 31, 2016, with the following inclusion criteria: subjects aged over 18 years, with at least 24 h of hospitalization and who had a complete medical history that could be accessed...
February 4, 2018: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29429122/optimal-control-approach-for-establishing-wmelpop-wolbachia-infection-among-wild-aedes-aegypti-populations
#10
Doris E Campo-Duarte, Olga Vasilieva, Daiver Cardona-Salgado, Mikhail Svinin
Wolbachia-based biocontrol has recently emerged as a potential method for prevention and control of dengue and other vector-borne diseases. Major vector species, such as Aedes aegypti females, when deliberately infected with Wolbachia become less capable of getting viral infections and transmitting the virus to human hosts. In this paper, we propose an explicit sex-structured population model that describes an interaction of uninfected (wild) male and female mosquitoes and those deliberately infected with wMelPop strain of Wolbachia in the same locality...
February 10, 2018: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29425232/identification-and-characterization-of-influenza-a-viruses-in-selected-domestic-animals-in-kenya-2010-2012
#11
Peninah Munyua, Clayton Onyango, Lydia Mwasi, Lilian W Waiboci, Geoffrey Arunga, Barry Fields, Joshua A Mott, Carol J Cardona, Philip Kitala, Philip N Nyaga, M Kariuki Njenga
BACKGROUND: Influenza A virus subtypes in non-human hosts have not been characterized in Kenya. We carried out influenza surveillance in selected domestic animals and compared the virus isolates with isolates obtained in humans during the same period. METHODS: We collected nasal swabs from pigs, dogs and cats; oropharyngeal and cloacal swabs from poultry; and blood samples from all animals between 2010 and 2012. A standardized questionnaire was administered to farmers and traders...
2018: PloS One
https://www.readbyqxmd.com/read/29419288/deciphering-the-role-of-dipolar-interactions-in-magnetic-layered-double-hydroxides
#12
Jose A Carrasco, Salvador Cardona-Serra, Juan Modesto Clemente-Juan, Alejandro Gaita-Ariño, Gonzalo Abellán, Eugenio Coronado
Layered double hydroxides (LDHs) exhibit unparalleled anion exchange properties and the ability to be exfoliated into 2D nanosheets, which can be used as a building block to fabricate a wide variety of hybrid functional nanostructured materials. Still, if one wants to use LDHs as a magnetic building blocks in the design of complex architectures, the role played by the dipolar magnetic interactions in these layered materials needs to be understood. In this work, we synthesized and characterized a five-membered CoAl-LDH series with basal spacing ranging from 7...
February 8, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29415477/fiber-optic-pyrometer-with-optically-powered-switch-for-temperature-measurements
#13
Carmen Vázquez, Sandra Pérez-Prieto, Juan D López-Cardona, Alberto Tapetado, Enrique Blanco, Jorge Moreno-López, David S Montero, Pedro C Lallana
We report the experimental results on a new infrared fiber-optic pyrometer for very localized and high-speed temperature measurements ranging from 170 to 530 °C using low-noise photodetectors and high-gain transimpedance amplifiers with a single gain mode in the whole temperature range. We also report a shutter based on an optical fiber switch which is optically powered to provide a reference signal in an optical fiber pyrometer measuring from 200 to 550 °C. The tests show the potential of remotely powering via optical means a 300 mW power-hungry optical switch at a distance of 100 m, avoiding any electromagnetic interference close to the measuring point...
February 6, 2018: Sensors
https://www.readbyqxmd.com/read/29378537/comprehensive-economic-evaluation-of-thermotherapy-for-the-treatment-of-cutaneous-leishmaniasis-in-colombia
#14
Jaiberth Antonio Cardona-Arias, Liliana López-Carvajal, Mery Patricia Tamayo-Plata, Iván Darío Vélez
BACKGROUND: Cutaneous leishmaniasis causes a high disease burden in Colombia, and available treatments present systemic toxicity, low patient compliance, contraindications, and high costs. The purpose of this study was to estimate the cost-effectiveness of thermotherapy versus Glucantime in patients with cutaneous leishmaniasis in Colombia. METHODS: Cost-effectiveness study from an institutional perspective in 8133 incident cases. Data on therapeutic efficacy and safety were included, calculating standard costs; the outcomes were disability adjusted life years (DALYs) and the number of patients cured...
January 29, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29374233/gwas-of-epigenetic-aging-rates-in-blood-reveals-a-critical-role-for-tert
#15
Ake T Lu, Luting Xue, Elias L Salfati, Brian H Chen, Luigi Ferrucci, Daniel Levy, Roby Joehanes, Joanne M Murabito, Douglas P Kiel, Pei-Chien Tsai, Idil Yet, Jordana T Bell, Massimo Mangino, Toshiko Tanaka, Allan F McRae, Riccardo E Marioni, Peter M Visscher, Naomi R Wray, Ian J Deary, Morgan E Levine, Austin Quach, Themistocles Assimes, Philip S Tsao, Devin Absher, James D Stewart, Yun Li, Alex P Reiner, Lifang Hou, Andrea A Baccarelli, Eric A Whitsel, Abraham Aviv, Alexia Cardona, Felix R Day, Nicholas J Wareham, John R B Perry, Ken K Ong, Kenneth Raj, Kathryn L Lunetta, Steve Horvath
DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9907 individuals, we find gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleration (EEAA). Mendelian randomization analysis suggests causal influences of menarche and menopause on IEAA and lipoproteins on IEAA and EEAA...
January 26, 2018: Nature Communications
https://www.readbyqxmd.com/read/29368904/-non-hodgkin-lymphoma-incidental-finding-in-a-renal-donor-10-years-after-the-evolution-in-recipient
#16
Juan Carlos H Hernández-Rivera, María Juana Pérez-López, José Guadalupe Cardona-Chavez, Conrado Alejandro Chucuan-Castillo, Mariana Salazar-Mendoza, José Paniagua-Sierra
BACKGROUND: The incidence of cancer in transplant recipients is higher than in the general population. Cutaneous and lymphoproliferative tumors are the primary neoplasms that will develop these patients. Little is known about the transmission of cancer in organ and tissue donation; it has been described that neoplasms can be transmitted to immunosuppressed patients when donor organs with neoplasms are inadvertently transplanted. CASE REPORT: Patient of 29 years of age who underwent kidney transplantation 10 years ago...
January 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29364039/neurophysiological-correlate-of-emotional-regulation-in-cognitive-and-motor-deficits-in-tourette-s-syndrome
#17
Navkiran Kalsi, Renata Tambelli, Daniela Altavilla, Cristina Trentini, Sara Panunzi, Mariella Stanca, Paola Aceto, Francesco Cardona, Carlo Lai
OBJECTIVES: The present study investigated the role of different emotions in the expression of cognitive and motor control abilities of children having Tourette's Syndrome (TS) compared to healthy controls. METHODS: The electroencephalography (EEG) activity of thirty-three children (mean age in final sample: TS (n = 10)=10.5±2.3; control (n = 10)=10.1±2.9) was recorded during a visual task consisting of four emotional face cues (anger, happiness, neutral and sadness) followed by a target in congruent or incongruent position with emotional cue...
January 24, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29363372/synthesis-biological-activity-and-molecular-modelling-studies-of-shikimic-acid-derivatives-as-inhibitors-of-the-shikimate-dehydrogenase-enzyme-of-escherichia-coli
#18
Dulce Catalina Díaz-Quiroz, César Salvador Cardona-Félix, José Luis Viveros-Ceballos, Miguel Angel Reyes-González, Franciso Bolívar, Mario Ordoñez, Adelfo Escalante
Shikimic acid (SA) pathway is the common route used by bacteria, plants, fungi, algae, and certain Apicomplexa parasites for the biosynthesis of aromatic amino acids and other secondary metabolites. As this essential pathway is absent in mammals designing inhibitors against implied enzymes may lead to the development of antimicrobial and herbicidal agents harmless to humans. Shikimate dehydrogenase (SDH) is the fourth enzyme of the SA pathway. In this contribution, a series of SA amide derivatives were synthesised and evaluated for in vitro SDH inhibition and antibacterial activity against Escherichia coli...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29362597/health-related-quality-of-life-of-rheumatic-disease-patients-treated-in-a-specialized-ips-in-medellin-colombia
#19
J Q Franco-Aguirre, A A Cardona-Tapias, J A Cardona-Arias
PURPOSE: To compare Health-Related Quality of Life (HRQOL) profiles and their associated factors in people with rheumatoid arthritis (RA), spondyloarthritis (SpA), fibromyalgia (FM) and rheumatoid comorbidity treated in a specialized health center (SHC) in Medellin, Colombia. METHODS: A cross-sectional analytical study was performed with 93 RA patients, 30 SpA patients, 41 primary FM patients and 48 secondary FM patients with a concurrent diagnosis of RA or SpA...
October 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29362421/sporadic-nesting-reveals-long-distance-colonisation-in-the-philopatric-loggerhead-sea-turtle-caretta-caretta
#20
Carlos Carreras, Marta Pascual, Jesús Tomás, Adolfo Marco, Sandra Hochsheid, Juan José Castillo, Patricia Gozalbes, Mariluz Parga, Susanna Piovano, Luis Cardona
The colonisation of new suitable habitats is crucial for species survival at evolutionary scale under changing environmental conditions. However, colonisation potential may be limited by philopatry that facilitates exploiting successful habitats across generations. We examine the mechanisms of long distance dispersal of the philopatric loggerhead sea turtle (Caretta caretta) by analysing 40 sporadic nesting events in the western Mediterranean. The analysis of a fragment of the mitochondrial DNA and 7 microsatellites of 121 samples from 18 of these nesting events revealed that these nests were colonising events associated with juveniles from distant populations feeding in nearby foraging grounds...
January 23, 2018: Scientific Reports
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