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https://www.readbyqxmd.com/read/28818987/response-assessment-of-68-ga-dota-e-c-rgdfk-2-pet-ct-for-lung-adenocarcinoma-patients-treated-with-nintedanib-plus-docetaxel
#1
Oscar Arrieta, Francisco O Garcia-Perez, David Michel-Tello, Laura-Alejandra Ramirez-Tirado, Quetzali Pitalua-Cortes, Graciela Cruz-Rico, Eleazar-Omar Macedo-Perez, Andres F Cardona, Jaime de la Garza-Salazar
Nintedanib is an oral angiokinase inhibitor used as a second-line treatment for non-small-cell lung cancer (NSCLC). New radiotracers, such as (68)Ga-DOTA-E-[c(RGDfK)]2, that target αvβ3 integrin might impact the clinical practice as a non-invasive method for assessing angiogenesis inhibitors. Methods: From July 2014 through October 2015, 38 patients received second-line nintedanib plus docetaxel. All the patients underwent PET/CT with (68)Ga-DOTA-E-[c(RGDfK)]2 radiotracer and blood-sample tests to quantify angiogenesis factors (FGF, VEGF and PDGF-AB) prior to and after completing 2 therapy cycles...
August 17, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28818571/timing-of-palliative-care-team-referrals-for-inpatients-receiving-rapid-response-services-a-retrospective-pilot-study-in-a-us-hospital
#2
M Williams, M Cardona-Morrell, P Stevens, J Bey, M E Smith Glasgow
BACKGROUND/OBJECTIVES: Research indicates up to one-third of rapid response team calls relate to end-of-life symptoms. The CriSTAL criteria were developed as a screening tool to identify high risk of death within three months. The primary purpose of this pilot study was to investigate the timing of palliative care referrals in patients receiving rapid response team services, and patients' CriSTAL criteria score on admission. The potential feasibility of using the CriSTAL tool to stimulate earlier Palliative Care Team (PCT) referral served as an underlying goal, and investigation of a relationship between specific CriSTAL criteria and the prediction of in-hospital death was a secondary objective...
August 8, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28818563/-lower-lymphocyte-response-in-severe-cases-of-acute-bronchiolitis-due-to-respiratory-syncytial-virus
#3
José Miguel Ramos-Fernández, David Moreno-Pérez, Cristina Antúnez-Fernández, Guillermo Milano-Manso, Ana María Cordón-Martínez, Antonio Urda-Cardona
INTRODUCTION: Acute bronchiolitis (AB) of the infant has a serious outcome in 6-16% of the hospital admitted cases. Its pathogenesis and evolution is related to the response of the T lymphocytes. The objective of the present study is to determine if the lower systemic lymphocytic response is related to a worse outcome of AB in hospitalised infants. PATIENTS AND METHOD: Retrospective observational-analytical study of cases-controls nested in a cohort of patients admitted due to RSV-AB between the period from October 2010 to March 2015...
August 14, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28817787/evaluation-of-the-electron-transfer-flavoprotein-etf-as-an-antibacterial-target-in-burkholderia-cenocepacia
#4
Maria S Stietz, Christina Lopez, Osasumwen Osifo, Marcelo Tolmasky, Silvia T Cardona
There are hundreds of essential genes in multidrug resistant bacterial genomes, but only a few of their products are exploited as antibacterial targets. An example is the electron flavoprotein (ETF) which is required for growth and viability in <i>Burkholderia cenocepacia</i>. Here, we evaluated ETF as an antibiotic target for <i>Burkholderia cepacia</i> complex (Bcc). Depletion of the bacterial ETF during infection of <i>Caenorhabditis elegans</i> significantly extended survival of the nematodes, proving that ETF is essential for survival of <i>B...
August 17, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28816989/disease-duration-of-rheumatoid-arthritis-is-a-predictor-of-vascular-stiffness-a-cross-sectional-study-in-patients-without-known-cardiovascular-comorbidities-a-strobe-compliant-article
#5
Mónica Vázquez-Del Mercado, Eduardo Gomez-Bañuelos, Efrain Chavarria-Avila, Ernesto Cardona-Muñoz, Carlos Ramos-Becerra, Adrián Alanis-Sanchez, David Cardona-Muller, Fernando Grover-Paez, Felipe de J Perez-Vazquez, Rosa-Elena Navarro-Hernandez, Jorge M Valadez-Soto, Adan A Saldaña-Millan, Lorena Gonzalez-Rosas, Gabriel Ramos-Lopez, Marcelo H Petri, Magnus Bäck
The aim of this study was to analyze the impact of disease duration on carotid to femoral pulse wave velocity (cfPWV) in rheumatoid arthritis (RA) patients without either known traditional cardiovascular risk factors or previous comorbidities.Patients with RA diagnosis attending the rheumatology outpatient clinic of Hospital Civil Juan I. Menchaca, Guadalajara, Mexico, were analyzed. A total of 106 RA patients without known traditional cardiovascular risk factors were selected. All subjects were evaluated for RA disease duration, RA disease activity score on 28 joints (DAS28), serum lipids, rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28815597/cardiac-action-potential-repolarization-re-visited-early-repolarization-shows-all-or-none-behaviour
#6
Beatriz Trenor, Karen Cardona, Javier Saiz, Denis Noble, Wayne Giles
In healthy mammalian hearts the action potential (AP) waveform initiates and modulates each contraction, or heartbeat. As a result, action potential height and duration are key physiological variables. In addition, rate-dependent changes in ventricular action potential duration (APD), and variations in APD at a fixed heart rate, are both reliable biomarkers of electrophysiological stability. Present guidelines for the likelihood that candidate drugs will increase arrhythmias rely on small changes in APD and Q-T intervals as criteria for Safety Pharmacology decisions...
August 17, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28798744/the-mast-cell-contact-and-coagulation-system-connection-in-anaphylaxis
#7
REVIEW
Mar Guilarte, Anna Sala-Cunill, Olga Luengo, Moisés Labrador-Horrillo, Victoria Cardona
Anaphylaxis is the most severe form of allergic reaction, resulting from the effect of mediators and chemotactic substances released by activated cells. Mast cells and basophils are considered key players in IgE-mediated human anaphylaxis. Beyond IgE-mediated activation of mast cells/basophils, further mechanisms are involved in the occurrence of anaphylaxis. New insights into the potential relevance of pathways other than mast cell and basophil degranulation have been unraveled, such as the activation of the contact and the coagulation systems...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28796202/the-complete-connectome-of-a-learning-and-memory-centre-in-an-insect-brain
#8
Katharina Eichler, Feng Li, Ashok Litwin-Kumar, Youngser Park, Ingrid Andrade, Casey M Schneider-Mizell, Timo Saumweber, Annina Huser, Claire Eschbach, Bertram Gerber, Richard D Fetter, James W Truman, Carey E Priebe, L F Abbott, Andreas S Thum, Marta Zlatic, Albert Cardona
Associating stimuli with positive or negative reinforcement is essential for survival, but a complete wiring diagram of a higher-order circuit supporting associative memory has not been previously available. Here we reconstruct one such circuit at synaptic resolution, the Drosophila larval mushroom body. We find that most Kenyon cells integrate random combinations of inputs but that a subset receives stereotyped inputs from single projection neurons. This organization maximizes performance of a model output neuron on a stimulus discrimination task...
August 9, 2017: Nature
https://www.readbyqxmd.com/read/28793302/safety-of-adrenaline-use-in-anaphylaxis-a-multicentre-register
#9
Victòria Cardona, Laia Ferré-Ybarz, Mar Guilarte, Nuria Moreno-Pérez, Catalina Gómez-Galán, Eva Alcoceba-Borràs, Maria Belén Delavalle, Teresa Garriga-Baraut
BACKGROUND: The use of intramuscular adrenaline to treat anaphylaxis is suboptimal, despite being the first-line treatment recommended by national and international anaphylaxis guidelines. Fear of potentially severe side effects may be one of the underlying factors. The aim of this study was to assess the incidence and severity of adverse side effects after the use of adrenaline in anaphylaxis, as well as potential risk factors. METHODS: Observational study based on a multicenter online registry of cases of adrenaline administration for suspected anaphylaxis...
August 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28792962/aberrant-cgmp-signaling-persists-during-recovery-in-mice-with-oxygen-induced-pulmonary-hypertension
#10
Marta Perez, Keng Jin Lee, Herminio J Cardona, Joann M Taylor, Mary E Robbins, Gregory B Waypa, Sara K Berkelhamer, Kathryn N Farrow
Bronchopulmonary dysplasia (BPD), a common complication of preterm birth, is associated with pulmonary hypertension (PH) in 25% of infants with moderate to severe BPD. Neonatal mice exposed to hyperoxia for 14d develop lung disease similar to BPD, with evidence of associated PH. The cyclic guanosine monophosphate (cGMP) signaling pathway has not been well studied in BPD-associated PH. In addition, there is little data about the natural history of hyperoxia-induced PH in mice or the utility of phosphodiesterase-5 (PDE5) inhibition in established disease...
2017: PloS One
https://www.readbyqxmd.com/read/28776607/-joven-fuerte-program-for-young-women-with-breast-cancer-in-mexico-%C3%A2-initial-results
#11
Cynthia Villarreal-Garza, Andrea Castro-Sánchez, Alejandra Platas, Melina Miaja, Alejandro Mohar-Betancourt, Regina Barragan-Carrillo, Alan Fonseca, Yoatzin Vega, B Alejandra Martinez-Cannon, Dione Aguilar, Enrique Bargalló-Rocha, Servando Cardona-Huerta, Omar Peña-Curiel, Juan Matus-Santoso
Despite the high rates of breast cancer among young Mexican women, their special needs and concerns have not been systematically addressed. To fulfill these unsatisfied demands, we have developed "Joven & Fuerte: Program for Young Women with Breast Cancer in Mexico," the first program dedicated to the care of young breast cancer patients in Latin America, which is taking place at the National Cancer Institute of Mexico and the two medical facilities of the Instituto Tecnológico y de Estudios Superiores de Monterrey...
July 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28771336/electric-field-generation-and-control-of-bipartite-quantum-entanglement-between-electronic-spins-in-mixed-valence-polyoxovanadate-gev14o40-8
#12
Andrew Palii, Sergey Aldoshin, Boris Tsukerblat, Juan José Borràs-Almenar, Juan Modesto Clemente-Juan, Salvador Cardona-Serra, Eugenio Coronado
As part of the search for systems in which control of quantum entanglement can be achieved, here we consider the paramagnetic mixed valence polyoxometalate K2Na6[GeV14O40]·10H2O in which two electrons are delocalized over the 14 vanadium ions. Applying a homogeneous electric field can induce an antiferromagnetic coupling between the two delocalized electronic spins that behave independently in the absence of the field. On the basis of the proposed theoretical model, we show that the external field can be used to generate controllable quantum entanglement between the two electronic spins traveling over a vanadium network of mixed valence polyoxoanion [GeV14O40](8-)...
August 3, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28769074/genetic-and-constitutional-factors-are-major-contributors-to-substantia-nigra-hyperechogenicity
#13
Juan F Vázquez-Costa, José I Tembl, Victoria Fornés-Ferrer, Fernando Cardona, Lluis Morales-Caba, Gerardo Fortea, Jordi Pérez-Tur, Teresa Sevilla
Hyperechogenicity of substantia nigra (SNh) is a frequent finding in amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and other movement disorders (MD) patients, but its meaning is unclear. To ascertain the contribution of different factors to SNh area, we measured it in 108 ALS, 102 PD, 91 other MD patients and 91 healthy controls. Demographical data were collected in all patients and controls. In ALS patients, we also recorded clinical variables, performed genetic analysis and measured baseline levels of ferritin...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28763796/the-metabolic-regulator-mtorc1-controls-terminal-myeloid-differentiation
#14
Pui Y Lee, David B Sykes, Sarah Ameri, Demetrios Kalaitzidis, Julia F Charles, Nathan Nelson-Maney, Kevin Wei, Pierre Cunin, Allyn Morris, Astrid E Cardona, David E Root, David T Scadden, Peter A Nigrovic
Monocytes are derived from hematopoietic stem cells through a series of intermediate progenitor stages, but the factors that regulate this process are incompletely defined. Using a Ccr2/Cx3cr1 dual-reporter system to model murine monocyte ontogeny, we conducted a small-molecule screen that identified an essential role of mechanistic target of rapamycin complex 1 (mTORC1) in the development of monocytes and other myeloid cells. Confirmatory studies using mice with inducible deletion of the mTORC1 component Raptor demonstrated absence of mature circulating monocytes, as well as disruption in neutrophil and dendritic cell development, reflecting arrest of terminal differentiation at the granulocyte-monocyte progenitor stage...
May 26, 2017: Science Immunology
https://www.readbyqxmd.com/read/28724898/improvement-in-the-production-of-the-human-recombinant-enzyme-n-acetylgalactosamine-6-sulfatase-rhgalns-in-escherichia-coli-using-synthetic-biology-approaches
#15
Luis H Reyes, Carolina Cardona, Luisa Pimentel, Alexander Rodríguez-López, Carlos J Alméciga-Díaz
Previously, we demonstrated production of an active recombinant human N-acetylgalactosamine-6-sulfatase (rhGALNS) enzyme in Escherichia coli as a potential therapeutic alternative for mucopolysaccharidosis IVA. However, most of the rhGALNS produced was present as protein aggregates. Here, several methods were investigated to improve production and activity of rhGALNS. These methods involved the use of physiologically-regulated promoters and alternatives to improve protein folding including global stress responses (osmotic shock), overexpression of native chaperones, and enhancement of cytoplasmic disulfide bond formation...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723474/introducing-the-twitter-impact-factor-an-objective-measure-of-urology-s-academic-impact-on-twitter
#16
Diana Cardona-Grau, Igor Sorokin, Gabriel Leinwand, Charles Welliver
BACKGROUND: Social media use in academia and urology is rising. Specifically, individual journals now have Twitter accounts (Twitter Inc, San Francisco, CA, USA) and regularly tweet academic content. OBJECTIVE: To present and evaluate the Twitter impact factor (TIF), a novel means of measuring a journal's academic influence in the realm of social media. DESIGN, SETTING, AND PARTICIPANTS: Journal Citation Reports (JCR; Thomson Reuters, New York, NY, USA) for 2014 was queried for urologic academic journals...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28717213/ferroelectric-paraelectric-transition-in-a-membrane-with-quenched-induced-%C3%AE-phase-of-pvdf
#17
O García-Zaldívar, T Escamilla-Díaz, M Ramírez-Cardona, M A Hernández-Landaverde, R Ramírez-Bon, J M Yañez-Limón, F Calderón-Piñar
The stabilization of δ-phase of poly(vinylidene fluoride) PVDF in a 14 µm-thickness ferroelectric membrane is achieved by a simple route based on the use of a dimethylformamide (DMF)/acetone solvent, in which the application of external electric field is not required. X-ray diffraction and calorimetric experiments on heating reveal that, at 154 °C, the original mixture between ferroelectric δ-phase and paraelectric α-phase transits to a system with only this latter phase in the crystalline fraction. A gradual and slight increment of amorphous fraction up to the melting at 161 °C is also observed...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716979/blood-biomarkers-for-the-early-diagnosis-of-stroke-the-stroke-chip-study
#18
Alejandro Bustamante, Elena López-Cancio, Sara Pich, Anna Penalba, Dolors Giralt, Teresa García-Berrocoso, Carles Ferrer-Costa, Teresa Gasull, María Hernández-Pérez, Mónica Millan, Marta Rubiera, Pedro Cardona, Luis Cano, Helena Quesada, Mikel Terceño, Yolanda Silva, Mar Castellanos, Moisés Garces, Silvia Reverté, Xavier Ustrell, Rafael Marés, Joan Josep Baiges, Joaquín Serena, Francisco Rubio, Eduardo Salas, Antoni Dávalos, Joan Montaner
BACKGROUND AND PURPOSE: Stroke diagnosis could be challenging in the acute phase. We aimed to develop a blood-based diagnostic tool to differentiate between real strokes and stroke mimics and between ischemic and hemorrhagic strokes in the hyperacute phase. METHODS: The Stroke-Chip was a prospective, observational, multicenter study, conducted at 6 Stroke Centers in Catalonia. Consecutive patients with suspected stroke were enrolled within the first 6 hours after symptom onset, and blood samples were drawn immediately after admission...
July 17, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28716320/evaluation-and-lifetime-management-of-the-urinary-tract-in-patients-with-myelomeningocele
#19
REVIEW
Diana Cardona-Grau, George Chiang
In the United States, there are an estimated 25,000 children ages 0 to 19 years and about 166,000 of all ages currently affected by spina bifida. Management is multimodal and can be complex. Management techniques vary throughout a child's lifetime, but the goals remain the same: prevention of urinary tract infections and establishing acceptable continence. Continence is addressed as the child reaches school age. Additional considerations such as development of urolithiasis and the associated burden are highlighted in adolescence and into adulthood...
August 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28713560/massive-open-online-courses-in-health-sciences-from-latin-american-institutions-a-need-for-improvement
#20
Carlos Culquichicón, Luis M Helguero-Santin, L Max Labán-Seminario, Jaime A Cardona-Ospina, Omar A Aboshady, Ricardo Correa
Background: Massive open online courses (MOOCs) have undergone exponential growth over the past few years, offering free and worldwide access to high-quality education. We identified the characteristics of MOOCs in the health sciences offered by Latin American institutions (LAIs). Methods: We screened the eight leading MOOCs platforms to gather their list of offerings. The MOOCs were classified by region and subject. Then, we obtained the following information: Scopus H-index for each institution and course instructor, QS World University Ranking® 2015/16 of LAI, and official language of the course...
2017: F1000Research
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