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https://www.readbyqxmd.com/read/27916127/in-situ-determination-of-v-v-by-diffusive-gradients-in-thin-films-and-inductively-coupled-plasma-mass-spectrometry-techniques-using-amberlite-ira-410-resin-as-a-binding-layer
#1
Karen Silva Luko, Amauri Antonio Menegário, Carlos Alfredo Suárez, Makenly Tafurt-Cardona, Jorge Henrique Pedrobom, Ana Marta Cavinato Marchini Rolisola, Everton Tiago Sulato, Chang Hung Kiang
Amberlite IRA-410 anionic exchange resin was evaluated as the binding layer for sampling V(V) by using Diffusive Gradients in Thin Films (DGT). V(V) was determined by inductively coupled plasma mass spectrometry (ICP-MS). Mass vs. time DGT deployments (ionic strength = 0.03 mol L(-1) NaNO3, pH = 5.6 and T = 23.5 ± 0.5 °C) was characterized by excellent linear relationship (R(2) = 0.9993) and a significant retention of V(V) by the binding layer. An exchange capacity of at least 40 μg V g(-1) resin was achieved for the proposed binding layer...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27908454/fulvestrant-500-mg-versus-anastrozole-1-mg-for-hormone-receptor-positive-advanced-breast-cancer-falcon-an-international-randomised-double-blind-phase-3-trial
#2
John F R Robertson, Igor M Bondarenko, Ekaterina Trishkina, Mikhail Dvorkin, Lawrence Panasci, Alexey Manikhas, Yaroslav Shparyk, Servando Cardona-Huerta, Kwok-Leung Cheung, Manuel Jesus Philco-Salas, Manuel Ruiz-Borrego, Zhimin Shao, Shinzaburo Noguchi, Jacqui Rowbottom, Mary Stuart, Lynda M Grinsted, Mehdi Fazal, Matthew J Ellis
BACKGROUND: Aromatase inhibitors are a standard of care for hormone receptor-positive locally advanced or metastatic breast cancer. We investigated whether the selective oestrogen receptor degrader fulvestrant could improve progression-free survival compared with anastrozole in postmenopausal patients who had not received previous endocrine therapy. METHODS: In this phase 3, randomised, double-blind trial, we recruited eligible patients with histologically confirmed oestrogen receptor-positive or progesterone receptor-positive, or both, locally advanced or metastatic breast cancer from 113 academic hospitals and community centres in 20 countries...
November 28, 2016: Lancet
https://www.readbyqxmd.com/read/27906710/who-s-your-daddy-paternal-inheritance-of-metabolic-disease-risk
#3
Elvira Isganaitis, Harumi Suehiro, Connie Cardona
PURPOSE OF REVIEW: Although the importance of optimizing mothers' health prior to conception and during pregnancy is now well accepted, recent data also implicate health and nutritional status of fathers as contributors to chronic disease risk in their progeny. This brief review will highlight recent epidemiological and experimental studies linking paternal overnutrition, undernutrition, and other forms of stress, to metabolic disease in the offspring. RECENT FINDINGS: The past 2 years have brought tremendous insights into the mechanisms by which paternal exposures can contribute to disease susceptibility in the next generation...
November 30, 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27901163/synthesis-and-biological-evaluation-of-simplified-pironetin-analogues-with-modifications-in-the-side-chain-and-the-lactone-ring
#4
Steven Roldán, Adrià Cardona, Laura Conesa, Juan Murga, Eva Falomir, Miguel Carda, J Alberto Marco
The preparation of several new analogues of the natural dihydropyrone pironetin is described. They differ from the natural product mainly in the nature of the side chain and the lactone ring. Their cytotoxic activity has been measured. In addition, their interaction with tubulin, their ability to inhibit the secretion of the vascular endothelial growth factor (VEGF) and the expression of angiogenesis and telomerase-related genes have been determined. Unexpectedly, and unlike pironetin, the lactones studied in this work do not interact with tubulin...
November 30, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27900469/holocene-changes-in-the-trophic-ecology-of-an-apex-marine-predator-in-the-south-atlantic-ocean
#5
Damián G Vales, Luis Cardona, Atilio F Zangrando, Florencia Borella, Fabiana Saporiti, R Natalie P Goodall, Larissa Rosa de Oliveira, Enrique A Crespo
Predators may modify their diets as a result of both anthropogenic and natural environmental changes. Stable isotope ratios of nitrogen and carbon in bone collagen have been used to reconstruct the foraging ecology of South American fur seals (Arctocephalus australis) in the southwestern South Atlantic Ocean since the Middle Holocene, a region inhabited by hunter-gatherers by millennia and modified by two centuries of whaling, sealing and fishing. Results suggest that the isotopic niche of fur seals from Patagonia has not changed over the last two millennia (average for the period: δ(13)C2200-0BP = -13...
November 29, 2016: Oecologia
https://www.readbyqxmd.com/read/27900437/bdnf-and-ltp-ltd-like-plasticity-of-the-primary-motor-cortex-in-gilles-de-la-tourette-syndrome
#6
L Marsili, A Suppa, F Di Stasio, D Belvisi, N Upadhyay, I Berardelli, M Pasquini, S Petrucci, M Ginevrino, G Fabbrini, F Cardona, G Defazio, A Berardelli
Gilles de la Tourette syndrome (GTS) is characterized by motor and vocal tics and often associated with obsessive-compulsive disorder (OCD). Responses to intermittent/continuous theta-burst stimulation (iTBS/cTBS), which probe long-term potentiation (LTP)-/depression (LTD)-like plasticity in the primary motor cortex (M1), are reduced in GTS. ITBS-/cTBS-induced M1 plasticity can be affected by brain-derived neurotrophic factor (BDNF) polymorphism. We investigated whether the BDNF polymorphism influences iTBS-/cTBS-induced LTP-/LTD-like M1 plasticity in 50 GTS patients and in 50 age- and sex-matched healthy subjects...
November 30, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27895895/allergy-immunotherapy-across-the-life-cycle-to-promote-active-and-healthy-ageing-from-research-to-policies-an-airways-integrated-care-pathways-icps-programme-item-action-plan-b3-of-the-european-innovation-partnership-on-active-and-healthy-ageing-and-the-global
#7
REVIEW
M A Calderon, P Demoly, T Casale, C A Akdis, C Bachert, M Bewick, B M Bilò, B Bohle, S Bonini, A Bush, D P Caimmi, G W Canonica, V Cardona, A M Chiriac, L Cox, A Custovic, F De Blay, P Devillier, A Didier, G Di Lorenzo, G Du Toit, S R Durham, P Eng, A Fiocchi, A T Fox, R Gerth van Wijk, R M Gomez, T Haathela, S Halken, P W Hellings, L Jacobsen, J Just, L K Tanno, J Kleine-Tebbe, L Klimek, E F Knol, P Kuna, D E Larenas-Linnemann, A Linneberg, M Matricardi, H J Malling, R Moesges, J Mullol, A Muraro, N Papadopoulos, G Passalacqua, E Pastorello, O Pfaar, D Price, P Rodriguez Del Rio, R Ruëff, B Samolinski, G K Scadding, G Senti, M H Shamji, A Sheikh, J C Sisul, D Sole, G J Sturm, A Tabar, R Van Ree, M T Ventura, C Vidal, E M Varga, M Worm, T Zuberbier, J Bousquet
Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27894314/self-assembly-of-hexahistidine-tagged-tobacco-etch-virus-capsid-protein-into-microfilaments-that-induce-igg2-specific-response-against-a-soluble-porcine-reproductive-and-respiratory-syndrome-virus-chimeric-protein
#8
Carlos Alberto Manuel-Cabrera, Alba Adriana Vallejo-Cardona, Eduardo Padilla-Camberos, Rodolfo Hernández-Gutiérrez, Sara Elisa Herrera-Rodríguez, Abel Gutiérrez-Ortega
BACKGROUND: Assembly of recombinant capsid proteins into virus-like particles (VLPs) still represents an interesting challenge in virus-based nanotechnologies. The structure of VLPs has gained importance for the development and design of new adjuvants and antigen carriers. The potential of Tobacco etch virus capsid protein (TEV CP) as adjuvant has not been evaluated to date. FINDINGS: Two constructs for TEV CP expression in Escherichia coli were generated: a wild-type version (TEV-CP) and a C-terminal hexahistidine (His)-tagged version (His-TEV-CP)...
November 29, 2016: Virology Journal
https://www.readbyqxmd.com/read/27891075/bace1-rnai-restores-the-composition-of-phosphatidylethanolamine-derivates-related-to-memory-improvement-in-aged-3xtg-ad-mice
#9
Javier G Villamil-Ortiz, Alvaro Barrera-Ocampo, Diego Piedrahita, Claudia M Velásquez-Rodríguez, Julian D Arias-Londoño, Gloria P Cardona-Gómez
β-amyloid (Aβ) is produced by the β-secretase 1 (BACE1)-mediated enzymatic cleavage of the amyloid precursor protein through the amyloidogenic pathway, making BACE1 a therapeutic target against Alzheimer's disease (AD). Alterations in lipid metabolism are a risk factor for AD by an unknown mechanism. The objective of this study was to determine the effect of RNA interference against BACE1 (shBACEmiR) on the phospholipid profile in hippocampal CA1 area in aged 3xTg-AD mice after 6 and 12 months of treatment compared to aged PS1KI mice...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27889219/join-the-discussion-on-twitter
#10
EDITORIAL
Diana Cardona-Grau
No abstract text is available yet for this article.
November 9, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27885469/nepa-a-fixed-oral-combination-of-netupitant-and-palonosetron-improves-control-of-chemotherapy-induced-nausea-and-vomiting-cinv-over-multiple-cycles-of-chemotherapy-results-of-a-randomized-double-blind-phase-3-trial-versus-oral-palonosetron
#11
Matti Aapro, Meinolf Karthaus, Lee Schwartzberg, Igor Bondarenko, Tomasz Sarosiek, Cristina Oprean, Servando Cardona-Huerta, Vincent Hansen, Giorgia Rossi, Giada Rizzi, Maria Elisa Borroni, Hope Rugo
PURPOSE: Antiemetic guidelines recommend co-administration of targeted prophylactic medications inhibiting molecular pathways involved in emesis. NEPA is a fixed oral combination of a new NK1 receptor antagonist (RA), netupitant (NETU 300 mg), and palonosetron (PALO 0.50 mg), a pharmacologically distinct 5-HT3 RA. NEPA showed superior prevention of chemotherapy-induced nausea and vomiting (CINV) compared with oral PALO in a single chemotherapy cycle; maintenance of efficacy/safety over continuing cycles is the objective of this study...
November 24, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27882575/influence-of-the-dipolar-interactions-on-the-relative-stability-in-spin-crossover-systems
#12
Salvador Cardona-Serra, Stefano Sanvito
Molecules exhibiting a spin-crossover transition have been proposed for a number of applications such as molecular switches, spintronic tunable interfaces, and single molecule gates. Both the rational design of new spin-crossover systems and the improvement of the properties of the already existing ones require a theoretical understanding of the relative energy of the high (HS) and low spin state (LS) molecules in the solid-state. This has proved to be very challenging so far. Here, we shed some light on the importance of considering the symmetry and the geometry of the crystallographic cell to correctly evaluate the influence of the dipolar interactions on the relative energies of the molecular complex in both different spin states...
November 24, 2016: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/27879418/histopathologic-effects-of-onabotulinum-toxin-a-treatment-in-pediatric-submandibular-glands
#13
Ashley Mosseri, Isabel Cardona, Miriam Blumenkrantz, Sam J Daniel
Onabotulinum toxin A (OBTXA) is an effective treatment for drooling. Our objective was to determine if there are histologic changes in the submandibular glands (SMGs) after repetitive OBTXA injections. The study included blinded histologic analysis and comparison of SMGs with ≥4 OBTXA injections versus controls who never received OBTXA. The number of acinar cells were counted, and the morphology of the cells was evaluated within each histologic sample of the SMGs. Thirty-one glands were analyzed (14 control, 17 cases)...
November 22, 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27875582/changes-in-intracellular-na-following-enhancement-of-late-na-current-in-virtual-human-ventricular-myocytes
#14
Karen Cardona, Beatriz Trenor, Wayne R Giles
The slowly inactivating or late Na+ current, INa-L, can contribute to the initiation of both atrial and ventricular rhythm disturbances in the human heart. However, the cellular and molecular mechanisms that underlie these pro-arrhythmic influences are not fully understood. At present, the major working hypothesis is that the Na+ influx corresponding to INa-L significantly increases intracellular Na+, [Na+]i; and the resulting reduction in the electrochemical driving force for Na+ reduces and (may reverse) Na+/Ca2+ exchange...
2016: PloS One
https://www.readbyqxmd.com/read/27872884/data-on-clinical-characteristics-of-a-heart-failure-patients-cohort-with-reduced-ejection-fraction-and-analysis-of-the-circulating-values-of-five-different-heart-failure-biomarkers-high-sensitivity-troponin-t-galectin-3-c-terminal-propeptide-of-type-i-procollagen
#15
M Batlle, B Campos, M Farrero, M Cardona, B González, M A Castel, J Ortiz, E Roig, M J Pulgarín, J Ramírez, J L Bedini, M Sabaté, P García de Frutos, F Pérez-Villa
In this article, the full description of a heart failure with reduced ejection fraction (HF_REF) cohort of 192 patients is provided. Tables with the baseline demographic, prior history, ECG parameters, echocardiographic parameters, laboratory values and pharmacological treatment of these patients are included. Also, the quartile values of the analyzed circulating biomarkers: high sensitivity Troponin T (hs-TnT), galectin-3 (Gal-3), C-terminal propeptide of type I procollagen (CICP), soluble AXL (sAXL) and Brain Natriuretic Peptide (BNP) are given...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27872679/the-oxidative-and-inflammatory-state-in-patients-with-acute-renal-graft-dysfunction-treated-with-tacrolimus
#16
Sandra Carrillo-Ibarra, José Ignacio Cerrillos-Gutiérrez, Ariadna Escalante-Núñez, Enrique Rojas-Campos, Benjamín Gómez-Navarro, Sonia Sifuentes-Franco, Ernesto Germán Cardona-Muñoz, Alejandra Guillermina Miranda-Díaz
Objective. To determine the oxidative stress/inflammation behavior in patients with/without acute graft dysfunction (AGD) with Tacrolimus. Methods. Cross-sectional study, in renal transplant (RT) recipients (1-yr follow-up). Patients with AGD and without AGD were included. Serum IL-6, TNF-α, 8-isoprostanes (8-IP), and Nitric Oxide (NO) were determined by ELISA; C-reactive protein (CRP) was determined by nephelometry; lipid peroxidation products (LPO) and superoxide dismutase (SOD) were determined by colorimetry...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27872063/in-vitro-exposure-to-increasing-micafungin-concentrations-easily-promotes-echinocandin-resistance-in-candida-glabrata-isolates
#17
María Ángeles Bordallo-Cardona, Pilar Escribano, Elia Gómez G de la Pedrosa, Laura Judith Marcos-Zambrano, Rafael Cantón, Emilio Bouza, Jesús Guinea
We assessed the in vitro susceptibility of five echinocandin-susceptible C. glabrata isolates after exposure to micafungin. The direct exposure to plates at different micafungin concentrations resulted in the inhibition of growth at 0.062 μg/ml. The progressive exposure was performed on plates with 0.031 μg/ml of micafungin and sequentially propagated on plates containing the next two-fold concentration; the MICs of micafungin and anidulafungin increased sequentially and all the isolates became echinocandin-resistant showing fks2 mutations...
November 21, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27869395/-allergen-immunotherapy-mechanisms-of-action-and-therapeutic-and-socioeconomic-impact-consensus-of-the-asociaci%C3%A3-n-colombiana-de-alergia-asma-e-imunolog%C3%A3-a
#18
Jorge Sánchez, Ricardo Cardona, Luis Caraballo, Carlos Serrano, Ruth Ramírez, Susana Díez, Elizabeth García, Ana María Segura, Alfonso Cepeda, María Minotas
Allergies comprise a set of highly prevalent diseases. When allergic processes are not controlled, they can endanger patients' health and lives, and have an important economic and social impact. The aim of this paper is to present a practical consensus of the scientific evidence on the use of immunotherapy in allergic diseases. A collaborative review made by various institutes and universities in Colombia was carried out upon request of the Asociación Colombiana de Alergia, Asma e Imunología, led by general practitioners, allergists, immunologists, internists and paediatricians with experience in the field of allergies...
September 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27869390/-factors-related-to-treatment-adherence-in-patients-with-tuberculosis-in-pereira-colombia-2012-2013
#19
Magally Dueñes, Dora Cardona
INTRODUCTION: According to the World Health Organization, the adherence to the tuberculosis treatment is the extent to which a patient's medication taking coincides with the prescribed treatment. The sum of cured patients and those who have completed treatment (directly observed therapy strategy, DOTS) are pragmatic indicators of the adherence. The patients who do not complete treatment correspond to non-adherents. Objective: To determine the relationship between anti-tuberculosis treatment adherence and socio-demographic, economic, clinical, and drug-related objective and subjective factors in patients over 18 years of age...
September 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27869387/-trends-in-pertussis-mortality-and-morbidity-in-colombia-2002-2012
#20
Doris Cardona, María Osley Garzón, Mateo Calle, Maite Catalina Agudelo, Ángela Segura
Whooping cough is a public health problem that mainly affects children under one year of age with highly lethal outcomes. It is a re-emerging disease, which is preventable by immunization. Objective: To analyze mortality and morbidity trends of whooping cough in Colombia between 2002 and 2012. Materials and methods: We conducted a quantitative descriptive study of deaths by pertussis between 2002 and 2012 using data from death certificates registered by the Departamento Administrativo Nacional de Estadística, and cases reported to the Sistema Nacional de Vigilancia en Salud Pública, 2005-2012...
September 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
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