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JOURNAL ARTICLE
Heather Weerdenburg, Hannah Walker, Nigel Curtis, Stephen Duffull, Gabrielle Haeusler, Theresa Cole, Amanda Gwee
OBJECTIVES: Posaconazole is increasingly used for the treatment and prophylaxis of invasive fungal infections in immunocompromised children. We aimed to review evidence for paediatric posaconazole dosing regimens focusing on attainment of target concentrations and frequency of adverse effects. METHODS: In May 2023, the Cochrane, Embase, MEDLINE and PubMed databases were searched for articles reporting posaconazole dosing in children with malignancy or post-haematopoietic stem cell transplantation...
April 18, 2024: Journal of Antimicrobial Chemotherapy
#22
JOURNAL ARTICLE
Rosa Rossi-Goldthorpe, Steven M Silverstein, James M Gold, Jason Schiffman, James A Waltz, Trevor F Williams, Albert R Powers, Scott W Woods, Richard E Zinbarg, Vijay A Mittal, Lauren M Ellman, Gregory P Strauss, Elaine F Walker, Jason A Levin, Santiago Castiello, Joshua Kenney, Philip R Corlett
The prediction error account of delusions has had success. However, its explanation of delusions with different contents has been lacking. Persecutory delusions and paranoia are the common unfounded beliefs that others have harmful intentions towards us. Other delusions include believing that one's thoughts or actions are under external control, or that events in the world have specific personal meaning. We compare learning on two different cognitive tasks, probabilistic reversal learning (PRL) and Kamin blocking, that have relationships to paranoid and non-paranoid delusion-like beliefs, respectively...
April 18, 2024: Brain
#23
JOURNAL ARTICLE
Collin D Teague, Tamara Markovic, Xianxiao Zhou, Freddyson J Martinez-Rivera, Angelica Minier-Toribio, Alexander Zinsmaier, Nathalia V Pulido, Kyra H Schmidt, Kelsey E Lucerne, Arthur Godino, Yentl Y van der Zee, Aarthi Ramakrishnan, Rita Futamura, Caleb J Browne, Leanne M Holt, Yun Young Yim, Corrine H Azizian, Deena M Walker, Li Shen, Yan Dong, Bin Zhang, Eric J Nestler
Cocaine use disorder is a significant public health issue without an effective pharmacological treatment. Successful treatments are hindered in part by an incomplete understanding of the molecular mechanisms that underlie long-lasting maladaptive plasticity and addiction-like behaviors. Here, we leverage a large RNA-sequencing dataset to generate gene co-expression networks across 6 interconnected regions of the brain's reward circuitry from mice that underwent saline or cocaine self-administration. We identify phosphodiesterase 1b ( Pde1b ), a Ca2+ /calmodulin-dependent enzyme that increases cAMP and cGMP hydrolysis, as a central hub gene within a nucleus accumbens (NAc) gene module that was bioinformatically associated with addiction-like behavior...
April 18, 2024: Journal of Neuroscience
#24
JOURNAL ARTICLE
Anna Turkova, Man K Chan, Cissy Kityo, Adeodata R Kekitiinwa, Philippa Musoke, Avy Violari, Ebrahim Variava, Moherndran Archary, Tim R Cressey, Suwalai Chalermpantmetagul, Kanokkorn Sawasdichai, Pradthana Ounchanum, Suparat Kanjanavanit, Sakulrat Srirojana, Ussanee Srirompotong, Steven Welch, Alasdair Bamford, Cristina Epalza, Clàudia Fortuny, Angela Colbers, Eleni Nastouli, Simon Walker, Dan Carr, Magda Conway, Moira J Spyer, Nazia Parkar, Iona White, Alessandra Nardone, Margaret J Thomason, Rashida A Ferrand, Carlo Giaquinto, Deborah Ford
BACKGROUND: There is increasing interest in utilising two-drug regimens for HIV treatment with the goal of reducing toxicity and improve acceptability. The D3 trial evaluates the efficacy and safety of DTG/3TC in children and adolescents and includes a nested pharmacokinetics(PK) substudy for paediatric drug licensing. METHODS: D3 is an ongoing open-label, phase III, 96-week non-inferiority randomised controlled trial(RCT) conducted in South Africa, Spain, Thailand, Uganda and the United Kingdom...
April 16, 2024: Contemporary Clinical Trials
#25
JOURNAL ARTICLE
Fc-silent anti-TIGIT antibodies potentiate anti-tumor immunity without depleting regulatory T cells.
Dana Piovesan, Amber E de Groot, Soonweng Cho, Amy E Anderson, Rebecca D Ray, Amita Patnaik, Paul G Foster, Casey G Mitchell, Alejandra Y Lopez Espinoza, Wandi S Zhu, Carlo E Stagnaro, Hema Singh, Xiaoning Zhao, Lisa Seitz, Nigel P Walker, Matthew J Walters, Kelsey E Sivick
TIGIT is an inhibitory receptor on immune cells that outcompetes an activating receptor, CD226, for shared ligands. Tumor-infiltrating lymphocytes express TIGIT and CD226 on regulatory T cells (Treg) and on CD8+ T cells with tumor-reactive or exhausted phenotypes, supporting the potential of therapeutically targeting TIGIT to enhance anti-tumor immunity. To optimize the efficacy of therapeutic antibodies against TIGIT, it is necessary to understand whether there is therapeutic benefit from Fcγ receptor (FcγR) binding...
April 18, 2024: Cancer Research
#26
JOURNAL ARTICLE
Laura D Zambrano, Margaret M Newhams, Regina M Simeone, Amanda B Payne, Michael Wu, Amber O Orzel-Lockwood, Natasha B Halasa, Jemima M Calixte, Pia S Pannaraj, Kanokporn Mongkolrattanothai, Julie A Boom, Leila C Sahni, Satoshi Kamidani, Kathleen Chiotos, Melissa A Cameron, Aline B Maddux, Katherine Irby, Jennifer E Schuster, Elizabeth H Mack, Austin Biggs, Bria M Coates, Kelly N Michelson, Katherine E Bline, Ryan A Nofziger, Hillary Crandall, Charlotte V Hobbs, Shira J Gertz, Sabrina M Heidemann, Tamara T Bradford, Tracie C Walker, Stephanie P Schwartz, Mary Allen Staat, Samina S Bhumbra, Janet R Hume, Michele Kong, Melissa S Stockwell, Thomas J Connors, Melissa L Cullimore, Heidi R Flori, Emily R Levy, Natalie Z Cvijanovich, Matt S Zinter, Mia Maamari, Cindy Bowens, Danielle M Zerr, Judith A Guzman-Cottrill, Ivan Gonzalez, Angela P Campbell, Adrienne G Randolph
Pediatric COVID-19 vaccination is effective in preventing COVID-19-related hospitalization, but duration of protection of the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated COVID-19 vaccines. During December 19, 2021-October 29, 2023, the Overcoming COVID-19 Network evaluated vaccine effectiveness (VE) of ≥2 original monovalent COVID-19 mRNA vaccine doses against COVID-19-related hospitalization and critical illness among U...
April 18, 2024: MMWR. Morbidity and Mortality Weekly Report
#27
JOURNAL ARTICLE
Roberto Vagnetti, Michele Vicovaro, Andrea Spoto, Luca Battaglini, Margherita Attanasio, Marco Valenti, Monica Mazza
Individuals with Autism Spectrum Disorder (ASD) present atypical sensory processing in the perception of moving stimuli and biological motion. The present study aims to explore the performance of young adults with ASD in a time to contact (TTC) estimation task involving social and non-social stimuli. TTC estimation involves extrapolating the trajectory of a moving target concealed by an occluder, based on the visible portion of its path, to predict the target's arrival time at a specific position. Sixteen participants with a diagnosis of level-1 ASD (M = 19...
April 18, 2024: Journal of Autism and Developmental Disorders
#28
JOURNAL ARTICLE
Qianying Zhou, Tong Li, Xidong Li, Lintao Wei, Jiaxin Luo, Lingling Bai, Wen-Jun Duan, Baoping Xie, Bin Sun, Jin-Xiang Chen, Zong Dai, Jun Chen
The identification of a specific tumor cell is crucial for the early diagnosis and treatment of cancer. However, it remains a challenge due to the limited sensitivity and accuracy, long response time, and low contrast of the recent approaches. In this study, we develop a dual miRNA-triggered DNA walker (DMTDW) assisted by APE1 for the specific recognition of tumor cells. miR-10b and miR-155 were selected as the research models. Without miR-10b and miR-155 presence, the DNA walker remains inactive as its walking strand of W is locked by L1 and L2...
April 18, 2024: Analytical Chemistry
#29
JOURNAL ARTICLE
Emma J Walker, Carlin J Hamill, Rory Crean, Michael S Connolly, Annmaree K Warrender, Kirsty L Kraakman, Erica J Prentice, Alistair Steyn-Ross, Moira Steyn-Ross, Christopher R Pudney, Marc W van der Kamp, Louis A Schipper, Adrian J Mulholland, Vickery L Arcus
Many enzymes display non-Arrhenius behavior with curved Arrhenius plots in the absence of denaturation. There has been significant debate about the origin of this behavior and recently the role of the activation heat capacity (Δ C P ⧧ ) has been widely discussed. If enzyme-catalyzed reactions occur with appreciable negative values of Δ C P ⧧ (arising from narrowing of the conformational space along the reaction coordinate), then curved Arrhenius plots are a consequence. To investigate these phenomena in detail, we have collected high precision temperature-rate data over a wide temperature interval for a model glycosidase enzyme MalL, and a series of mutants that change the temperature-dependence of the enzyme-catalyzed rate...
April 5, 2024: ACS Catalysis
#30
JOURNAL ARTICLE
Erika M Rosen, Andrew Walker, Pamela J Trangenstein, Cassidy R LoParco, Melvin D Livingston, Adam E Barry, Matthew E Rossheim
AIMS: Sweeping policy changes during the COVID-19 pandemic increased alcohol availability through permitted to-go sales, potentially posing unique risks to college students. While to-go sales may make binge drinking more convenient, little remains known about these practices. Therefore, this study aimed to assess whether drinking establishments' to-go sales practices are associated with their other operational practices and state policy. METHOD: This cross-sectional analysis included 221 randomly selected bars, nightclubs, and restaurants within two miles of a large public university...
March 16, 2024: Alcohol and Alcoholism
#31
JOURNAL ARTICLE
Clive Ellegaard, Mogens T Levinsen
While bouncing walking silicone oil droplets (walkers) do show many quantumlike phenomena, the original, most intriguing, double-slit experiment with walkers has been shown to be an overinterpretation of data. Several experiments and numerical simulations have proven that for at least some parameter region there is no randomness. Still, true randomness was claimed to be observed in an experiment on chaotically bouncing walkers. Also, most of the available phase space has not been investigated. The main goal of this paper is therefore to look for true interference and chaos in the entire phase space...
March 2024: Physical Review. E
#32
JOURNAL ARTICLE
Rosa Flaquer-Galmés, Daniel Campos, Vicenç Méndez
We analyze a one-dimensional intermittent random walk on an unbounded domain in the presence of stochastic resetting. In this process, the walker alternates between local intensive search, diffusion, and rapid ballistic relocations in which it does not react to the target. We demonstrate that Poissonian resetting leads to the existence of a non-equilibrium steady state. We calculate the distribution of the first arrival time to a target along with its mean and show the existence of an optimal reset rate. In particular, we prove that the initial condition of the walker, i...
March 2024: Physical Review. E
#33
JOURNAL ARTICLE
Sara J Walker, Sydney Ey, Susan Hedlund
OBJECTIVE: Pre-pandemic, the healthcare workforce was already at risk for higher burnout than the general population and, in some roles (e.g., physicians, nurses), at higher risk for clinical distress and suicide. Studies of healthcare workforce well-being during and after past pandemics reflect that distress can persist after a pandemic subsides, if adequate support within the workplace is not forthcoming and accessible. The current report presents the rationale for and development of a wellness consult service to provide support to leaders and teams in an academic medical center during the COVID-19 pandemic and now as teams work to recover and rebuild after years of significant pandemic and other stressors...
April 17, 2024: Academic Psychiatry
#34
JOURNAL ARTICLE
Jiaqing Zhu, Jiahao Sun, Jinzhu Liu, Bowen Ma, Chiyu Zhang, Chao Zhang, Tianwei Xia, Jirong Shen
OBJECTIVE: To explore the short-term effectiveness of hip revision surgery guided by artificial intelligence preoperative planning (AIHIP) system. METHODS: The clinical data of 22 patients (23 hips) who were admitted between June 2019 and March 2023 and met the selection criteria were retrospectively analyzed. There were 12 males and 10 females with an average age of 69.7 years (range, 44-90 years). There were 19 hips in the first revision, 3 hips in the second revision, and 1 hip in the third revision...
April 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
#35
JOURNAL ARTICLE
Kathleen M Zacherl, Emily Carper Sterrett, Brenna L Hughes, Karley M Whelan, James Tyler-Walker, Samuel T Bauer, Heather C Talley, Laura J Havrilesky
OBJECTIVE: To improve timely and equitable access to postpartum blood pressure (BP) monitoring in individuals with hypertensive disorders of pregnancy (HDP). METHODS: A quality improvement initiative was implemented at a large academic medical centre in the USA for postpartum individuals with HDP. The primary aim was to increase completed BP checks within 7 days of hospital discharge from 40% to 70% in people with HDP in 6 months. Secondary aims included improving rates of scheduled visits, completed visits within 3 days for severe HDP and unattended visits...
April 17, 2024: BMJ Quality & Safety
#36
JOURNAL ARTICLE
Jennifer L Bryan, David Wittkower, Lisa Walker, Alfred Ozanian, Michael Fisher, Ali A Asghar-Ali
The Department of Veteran Affairs established Readjustment Counseling Service (RCS) to meet the mental health needs of active-duty service members, veterans, and their families. A diverse therapeutic skill set is needed to serve this complex population. To assess training needs, a national mixed-methods needs assessment consisting of a survey for RCS counselors and focus groups among counselors, RCS educational trainers, and national leadership was conducted. Survey results ( n = 681) showed that RCS counselors were most interested in trainings on moral injury, acceptance and commitment therapy, and military sexual trauma (MST)...
April 16, 2024: Journal of Cognitive Psychotherapy
#37
JOURNAL ARTICLE
Xia Lu, Long Wang, Guowei Li, Yuxin Wang, Guo Hao, Yi Ding, Mengjia Liu, Shangchen Fu, Liqing Xu, Na Ge, Wupeng Ge
In this work, a novel 3D-DNA walker signal amplification strategy was designed to construct a fluorescent aptasensor for the detection of kanamycin (KAN). The aptasensor utilizes split aptamers for the synergistic recognition of KAN. The presence of KAN induces the split aptamers recombination to form the Mg2+ -DNAzyme structure, which is activated by Mg2+ to drive the 3D-DNA walker process for cascading signal amplification. Employing gold nanoflowers (AuNFs) as walking substrate material increases the local DNA concentration to enhance the walker efficiency...
April 15, 2024: Science of the Total Environment
#38
JOURNAL ARTICLE
Jessica L Fairley, Dylan Hansen, Susanna Proudman, Joanne Sahhar, Gene-Siew Ngian, Jenny Walker, Lauren V Host, André La Gerche, David Prior, Andrew Burns, Kathleen Morrisroe, Wendy Stevens, Mandana Nikpour, Laura Ross
OBJECTIVES: To quantify the frequency and clinical implications of systemic sclerosis (SSc)-associated left ventricular function (LV) impairment. METHODS: Australian Scleroderma Cohort Study participants meeting ACR/EULAR criteria for SSc with ≥1 echocardiographic LVEF measurement were included. Overt LV dysfunction was indicated by reduced LV ejection fraction (LVEF) and subclinical LV dysfunction was measured using impaired LV global longitudinal strain (LV-GLS>-16 %)...
April 6, 2024: Seminars in Arthritis and Rheumatism
#39
JOURNAL ARTICLE
Jenny J Linnoila, Otto Rapalino, Melissa A Walker, Maria Martinez-Lage
New England Journal of Medicine, Volume 390, Issue 15, Page 1421-1430, April 2024.
April 18, 2024: New England Journal of Medicine
#40
JOURNAL ARTICLE
Robert C Walker, Jack Harrington, Stella P Breininger, Oliver Pickering, Samuel L Hill, Benjamin P Sharpe, Ben Grace, Ian Reddin, Rushda Rajak, Antigoni Manousopoulou, Spiros D Garbis, Zoë S Walters, Matthew J J Rose-Zerilli, Timothy J Underwood
No abstract text is available yet for this article.
April 3, 2024: British Journal of Surgery
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