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https://www.readbyqxmd.com/read/28544947/measuring-cortical-motor-hemodynamics-during-assisted-stepping-an-fnirs-feasibility-study-of-using-a-walker
#1
Andrea Cristina de Lima-Pardini, Guilherme A Zimeo Morais, Joana Bisol Balardin, Daniel Boari Coelho, Nametala Maia Azzi, Luis Augusto Teixeira, João Ricardo Sato
Walkers are commonly prescribed worldwide to individuals unable to walk independently. Walker usage leads to improved postural control and voluntary movement during step. In the present study, we aimed to provide a concept-proof on the feasibility of an event-related protocol integrating the analyses of biomechanical variables of step initiation and functional near-infrared spectroscopy (fNIRS) to measure activation of the supplementary motor area (SMA) while using a walker. Healthy young participants were tested while stepping with versus without the use of the walker...
May 17, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28544813/nursing-diagnosis-risk-for-delayed-surgical-recovery-00246-concept-clarification-and-definition-of-empirical-referents
#2
Simone Martins Rembold, Rosimere Ferreira Santana, Priscilla Alfradique de Souza, Sócrates Miranda de Oliveira Xavier Schwartz
PURPOSE: To clarify the concept of risk for delayed surgical recovery (00246) and to define the empirical referents for identification of predictive factors of delay in recovery. METHOD: A concept analysis was developed based on the eight steps proposed by Walker and Avant. RESULTS: Defining attributes were determined and antecedents and consequents identified. Cases were proposed cases and empirical referents established. CONCLUSION: The results provided evidences and instrumentalize empirical referents, which may support an accurate nursing diagnosis...
May 23, 2017: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/28544554/concept-analysis-of-posttraumatic-stress-disorder
#3
Bikram Sekhon
PURPOSE: Mental health nursing is not the same as psychiatry, so it is important for nurses to have an understanding of the defining attributes, antecedents, consequences, model cases, and empirical referents of post-traumatic stress disorder (PTSD). METHOD: Walker and Avant's (2005) method is used to guide this concept analysis of PTSD. FINDINGS: Four attributes arise from this concept analysis, which are addressed through both the DSM-IV and DSM-5 (American Psychiatric Association, /): triggering event or events, re-experiencing, fear, and helplessness...
May 23, 2017: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/28544485/preservation-of-surface-conductivity-and-dielectric-loss-tangent-in-large-scale-encapsulated-epitaxial-graphene-measured-by-noncontact-microwave-cavity-perturbations
#4
Albert F Rigosi, Nicholas R Glavin, Chieh-I Liu, Yanfei Yang, Jan Obrzut, Heather M Hill, Jiuning Hu, Hsin-Yen Lee, Angela R Hight Walker, Curt A Richter, Randolph E Elmquist, David B Newell
Regarding the improvement of current quantized Hall resistance (QHR) standards, one promising avenue is the growth of homogeneous monolayer epitaxial graphene (EG). A clean and simple process is used to produce large, precise areas of EG. Properties like the surface conductivity and dielectric loss tangent remain unstable when EG is exposed to air due to doping from molecular adsorption. Experimental results are reported on the extraction of the surface conductivity and dielectric loss tangent from data taken with a noncontact resonance microwave cavity, assembled with an air-filled, standard R100 rectangular waveguide configuration...
May 19, 2017: Small
https://www.readbyqxmd.com/read/28544037/using-experience-based-co-design-for-the-development-of-physical-activity-provision-in-non-acute-rehabilitation-and-recovery-mental-health-care
#5
Evan Matthews, Mary Cowman, Suzanne Denieffe
Despite advances in recovery focused mental health care, people with severe mental illness (SMI) experience multiple physical comorbidity compounded by unhealthy lifestyle behaviours including low levels of physical activity (Vancampfort et al. 2017; Walker et al. 2015). Responding to this, international policy is moving to include physical activity as part of fundamental care for people with severe mental illness (Pratt et al. 2016; Richardson et al. 2005). Incorporation of physical activity into mental health service provision should adopt an approach that is in keeping with best practice, recovery orientated guidelines of mental health service provision, with particular consideration shown to incorporating service users as partners in care plan development and delivery (Department of Health, 2001; Department of Health and Children, 2006)...
May 19, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28543216/bridging-with-tirofiban-during-oral-antiplatelet-interruption-a-single-center-case-series-analysis-including-patients-on-hemodialysis
#6
Elizabeth A Walker, William E Dager
INTRODUCTION: Surgical patients requiring an interruption in dual-antiplatelet therapy (DAPT) within 6 months of cardiac stenting are at risk for thrombotic events. Bridging with short-acting intravenous antiplatelet agents has been proposed to minimize the risk of thrombotic and hemorrhagic complications. METHODS: This was a retrospective analysis of a tirofiban bridging strategy that did not use an initial bolus loading dose. Tirofiban infusions were initiated 24to 48 hours after the last oral antiplatelet dose at a rate of 0...
May 23, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28542898/health-habit-a-concept-analysis
#7
Andra S Opalinski, Linda S Weglicki, Sareen S Gropper
The aim of this article is to provide clarity of the concept of health habit. Using Walker and Avant's (1983; 2010) method for conducting a concept analysis, the authors identify the attributes and characteristics of health habit, its theoretical and practical application to nursing, and sample cases to further illustrate the concept. Empirical and conceptual literature was used to inform this concept analysis. Articles and one book from 1977 to 2014 were reviewed from PsycINFO, Medline, Cumulative Index to Nursing Health Literature (CINAHL), Science Direct, EBSCOhost and Web of Science...
May 25, 2017: Nursing Forum
https://www.readbyqxmd.com/read/28542489/d-helix-influences-dimerization-of-the-atp-binding-cassette-abc-transporter-associated-with-antigen-processing-1-tap1-nucleotide-binding-domain
#8
Ahmet S Vakkasoglu, Sriram Srikant, Rachelle Gaudet
ATP-binding cassette (ABC) transporters form a large family of transmembrane importers and exporters. Using two nucleotide-binding domains (NBDs), which form a canonical ATP-sandwich dimer at some point within the transport cycle, the transporters harness the energy from ATP binding and hydrolysis to drive substrate transport. However the structural elements that enable and tune the dimerization propensity of the NBDs have not been fully elucidated. Here we compared the biochemical properties of the NBDs of human and rat TAP1, a subunit of the heterodimeric transporter associated with antigen processing (TAP)...
2017: PloS One
https://www.readbyqxmd.com/read/28542020/ciclovia-in-a-rural-latino-community-results-and-lessons-learned
#9
Cynthia K Perry, Linda K Ko, Lidia Hernandez, Rosa Ortiz, Sandra Linde
CONTEXT: Ciclovias involve the temporary closure of roads to motorized vehicles, allowing for use by bicyclists, walkers, and runners and for other physical activity. Ciclovias have been held in urban and suburban communities in the United States and Latin America. OBJECTIVE: We evaluated the first ciclovia held in a rural, predominantly Latino community in Washington State. SETTING: Three blocks within a downtown area in a rural community were closed for 5 hours on a Saturday in July 2015...
July 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28541862/nonoperative-management-of-the-damaged-spleen-a-community-surgeon-looks-back
#10
Mark L Walker
Blunt spleen injury is usually managed nonoperatively. An 8-year retrospective analysis by one community surgeon was done to provide an overview of the role of CT, angiography, and transfusion in the management algorithm. A total of 2750 patients were screened and 125 patients were identified with spleen injury. Of these 125 patients, 72 were managed without surgery. These were young (mean age 32 ± 16 years) patients with mean Injury Severity Score of 16 ± 8. Angiography was used in 14 patients. These patients received more blood (5 ± 6 vs 2 ± units of packed red blood cells) than their nonangiogram counterparts...
May 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28541665/identification-of-small-molecule-translesion-synthesis-inhibitors-that-target-the-rev1-ct-rir-protein-protein-interaction
#11
Vibhavari Sail, Alessandro A Rizzo, Nimrat Chatterjee, Radha Charan Dash, Zuleyha Ozen, Graham C Walker, Dmitry M Korzhnev, M Kyle Hadden
Translesion synthesis (TLS) is an important mechanism through which proliferating cells tolerate DNA damage during replication. The mutagenic Rev1/Polζ-dependent branch of TLS helps cancer cells survive first-line genotoxic chemotherapy and introduces mutations that can contribute to the acquired resistance so often observed with standard anti-cancer regimens. As such, inhibition of Rev1/Polζ-dependent TLS has recently emerged as a strategy to enhance the efficacy of first-line chemotherapy and reduce the acquisition of chemoresistance by decreasing tumor mutation rate...
May 25, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28541421/a-homozygous-donor-splice-site-mutation-in-the-meiotic-gene-msh4-causes-primary-ovarian-insufficiency
#12
Carolina Carlosama, Maëva El Zaiat, Liliana C Patiño, Heidi E Mateus, Reiner A Veitia, Paul Laissue
Premature ovarian insufficiency (POI) is a frequent pathology that affects women under 40 years of age, characterized by an early cessation of menses and high FSH levels. Despite recent progresses in molecular diagnosis, the etiology of POI remains idiopathic in most cases. Whole-exome sequencing of members of a Colombian family affected by POI allowed us to identify a novel homozygous donor splice-site mutation in the meiotic gene MSH4 (MutS Homolog 4). The variant followed a strict mendelian segregation within the family and was absent in a cohort of 135 women over 50 years of age without history of infertility, from the same geographical region as the affected family...
May 24, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28540148/clinical-and-microbiological-characteristics-of-bacteroides-prosthetic-joint-infections
#13
Neel Shah, Douglas Osmon, Aaron J Tande, James Steckelberg, Rafael Sierra, Randall Walker, Elie F Berbari
Clinical and microbiological characteristics of patients with Bacteroides prosthetic joint infection (PJI) have not been well described in the literature. The aim of this retrospective cohort study was to assess the outcome of patients with Bacteroides PJI and to review risk factors associated with failure of therapy. Between 1/1969 and 12/2012, 20 episodes of Bacteroides PJI in 17 patients were identified at our institution. The mean age of the patients in this cohort at the time of diagnosis was 55.6 years; 59% (n=10) had knee involvement...
2017: J Bone Jt Infect
https://www.readbyqxmd.com/read/28539871/protein-quality-control-and-the-amyotrophic-lateral-sclerosis-frontotemporal-dementia-continuum
#14
Hamideh Shahheydari, Audrey Ragagnin, Adam K Walker, Reka P Toth, Marta Vidal, Cyril J Jagaraj, Emma R Perri, Anna Konopka, Jessica M Sultana, Julie D Atkin
Protein homeostasis, or proteostasis, has an important regulatory role in cellular function. Protein quality control mechanisms, including protein folding and protein degradation processes, have a crucial function in post-mitotic neurons. Cellular protein quality control relies on multiple strategies, including molecular chaperones, autophagy, the ubiquitin proteasome system, endoplasmic reticulum (ER)-associated degradation (ERAD) and the formation of stress granules (SGs), to regulate proteostasis. Neurodegenerative diseases are characterized by the presence of misfolded protein aggregates, implying that protein quality control mechanisms are dysfunctional in these conditions...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28539342/multicenter-clinical-evaluation-of-the-luminex-aries%C3%A2-flu-a-b-rsv-assay-for-pediatric-and-adult-respiratory-tract-specimens
#15
Stefan Juretschko, James Mahony, Richard S Buller, Ryhana Manjj, Sherry Dunbar, Kimberly Walker, Arundhati Rao
Influenza A and B viruses and respiratory syncytial virus (RSV) are three common viruses implicated in seasonal respiratory tract infections and a major cause of morbidity and mortality in adults and children worldwide. In recent years, an increasing number of commercial molecular tests have become available to diagnose respiratory viral infections. The Luminex® ARIES® Flu A/B & RSV Assay is a fully automated sample-to-answer molecular diagnostic assay for the detection of influenza A, influenza B and RSV...
May 24, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28537542/malonate-degradation-in-acinetobacter-baylyi-adp1-operon-organization-and-regulation-by-mdcr
#16
Julie L Stoudenmire, Alicia L Schmidt, Melissa P Tumen-Velasquez, Kathryn T Elliott, Nicole S Laniohan, S Walker Whitley, Nickolaus R Galloway, Melesse Nune, Michael West, Cory Momany, Ellen L Neidle, Anna C Karls
Transcriptional regulators in the LysR or GntR families are typically encoded in the genomic neighbourhood of bacterial genes for malonate degradation. While these arrangements have been evaluated using bioinformatics methods, experimental studies demonstrating co-transcription of predicted operons were lacking. Here, transcriptional regulation was characterized for a cluster of mdc genes that enable a soil bacterium, Acinetobacter baylyi ADP1, to use malonate as a carbon source. Despite previous assumptions that the mdc-gene set forms one operon, our studies revealed distinct promoters in two different regions of a nine-gene cluster...
May 25, 2017: Microbiology
https://www.readbyqxmd.com/read/28537518/parenteral-nutrition-lipid-injectable-emulsion-products-shortage-considerations
#17
Steve Plogsted, Stephen C Adams, Karen Allen, M Petrea Cober, June Greaves, Amy Ralph, Daniel T Robinson, Kim Sabino, Renee Walker, Ceressa T Ward, Joe Ybarra, Beverly Holcombe
No abstract text is available yet for this article.
June 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28537398/discovery-of-clinical-candidate-2-2s-6s-2-phenyl-6-hydroxyadamantan-2-yl-1-3-hydroxyazetidin-1-yl-ethanone-bms-816336-an-orally-active-novel-selective-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-inhibitor
#18
Xiang-Yang Ye, Stephanie Y Chen, Shung Wu, David S Yoon, Haixia Wang, Zhenqiu Hong, Stepen P O'Connor, Jun Li, James J Li, Lawrence L Kennedy, Steven J Walker, Akbar Nayeem, Steven Sheriff, Daniel M Camac, Vidyhashankar Ramamurthy, Paul E Morin, Rachel Zebo, Joseph R Taylor, Nathan N Morgan, Randolph P Ponticiello, Thomas Harrity, Atsu Apedo, Rajasree Golla, Ramakrishna Seethala, Mengmeng Wang, Timothy W Harper, Bogdan G Sleczka, Bin He, Mark Kirby, David K Leahy, Jianqing Li, Ronald L Hanson, Zhiwei Guo, Yi-Xin Li, John D DiMarco, Raymond Scaringe, Brad D Maxwell, Frederick Moulin, Joel C Barrish, David A Gordon, Jeffrey A Robl
BMS-816336 (6n-2), a hydroxyl-substituted adamantyl acetamide, has been identified as a novel, potent inhibitor against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme (IC50 3.0 nM) with >10000 fold selectivity over human 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). BMS-816336 exhibits a robust acute pharmacodynamic effects in cynomolgus monkeys (ED50 0.13 mpk) and in DIO mice. It is orally bioavailable (%F ranges from 20-72% in preclinical species) and has a predicted pharmacokinetic profile of a high peak to trough ratio and short half-life in humans...
May 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28537210/demographic-characteristics-of-australian-health-consumers-who-were-early-registrants-for-opt-in-personally-controlled-electronic-health-records
#19
Emma Torrens, Sue M Walker
BACKGROUND: Differential uptake of, or access to, personal electronic health records (PEHRs) has the potential to impact on health disparities among certain social groups. In 2012, the Australian Government introduced the Personally Controlled Electronic Health Record (PCEHR), an opt-in system operated by the then National E-Health Transition Authority (NEHTA). In July 2016, the My Health Record (MyHR), an opt-out model, operated by the Australian Digital Health Agency replaced the PCEHR, providing additional support for consumers...
January 1, 2017: HIM Journal
https://www.readbyqxmd.com/read/28535262/developmental-studies-of-maize-infesting-picture-winged-flies-diptera-ulidiidae
#20
Gaurav Goyal, Gregg S Nuessly, Dakshina R Seal, Gary J Steck, John L Capinera, Kenneth J Boote
Eleven species of picture-winged flies (Diptera: Ulidiidae) attack maize (Zea mays L.) in the Americas. Field and laboratory studies were used to determine developmental times on sweet corn ears for the three most common species attacking the crop in the United States, Chaetopsis massyla (Walker), Euxesta eluta Loew, and Euxesta stigmatias Loew. Egg plus larval stage developmental times were evaluated in early Spring and late Fall 2009, and late Spring 2010, by placing newly deposited eggs in protected ears in the field...
May 23, 2017: Environmental Entomology
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