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Zofia Bakuła, Anna Brzostek, Paulina Borówka, Anna Żaczek, Izabela Szulc-Kiełbik, Agata Podpora, Paweł Parniewski, Dominik Strapagiel, Jarosław Dziadek, Małgorzata Proboszcz, Jacek Bielecki, Jakko van Ingen, Tomasz Jagielski
Molecular epidemiological studies of Mycobacterium kansasii are hampered by the lack of highly-discriminatory genotyping modalities. The purpose of this study was to design a new, high-resolution fingerprinting method for M. kansasii. Complete genome sequence of the M. kansasii ATCC 12478 reference strain was searched for satellite-like repetitive DNA elements comprising tandem repeats. A total of 24 variable-number tandem repeat (VNTR) loci were identified with potential discriminatory capacity. Of these, 17 were used to study polymorphism among 67 M...
March 13, 2018: Scientific Reports
M Dumas, C Hua, C Hotz, C Velter, T A Duong, T Maraffi, N Ortonne, S Hüe, L Fardet, N de Prost, P Wolkenstein, S Ingen-Housz-Oro, O Chosidow
Toxic epidermal necrolysis (TEN, Lyell syndrome) and Stevens-Johnson syndrome are severe cutaneous adverse reactions to drugs characterized by epidermal necrolysis (EN). However, in 15% of cases, no causative drug is identified. In these cases, other triggers such as Mycoplasma pneumoniae have been described. Furthermore, the role of lupus as triggering factor has been suggested. We report 2 cases of EN without any drug causality, revealing autoimmune diseases as a cause. This article is protected by copyright...
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
E E Becerril-Garcia, D Petatan-Ramirez, I Ortiz-Aguirre, A Ayala-Bocos
This is the first record of the Pacific seahorse Hippocampus ingens at a northern oceanic island from the eastern Pacific Ocean. The photographic record of the juvenile female H. ingens was made in November 2015 during a cage diving trip at Guadalupe Island, Mexico. The presence of H. ingens in this area could be related to long distance dispersal mechanisms, as has been observed in other species of seahorses.
March 7, 2018: Journal of Fish Biology
ShengQi Xiang, Ulric B le Paige, Velten Horn, Klaartje Houben, Marc Baldus, Hugo van Ingen
Chromatin function depends on a dense network of interactions between nucleosomes and wide range of proteins. A detailed description of these protein-nucleosome interactions is required to reach a full molecular understanding of chromatin function in both genetics and epigenetics. Here, we show that the structure, dynamics and interactions of nucleosomes can be interrogated in a residue-specific manner using state-of-the-art solid-state NMR. Using sedimented nucleosomes, high-resolution spectra are obtained for both flexible histone tails and the non-mobile histone core...
February 21, 2018: Angewandte Chemie
Bendik Slagsvold Winsvold, Annike Marvik, John-Anker Zwart, Anne Hege Aamodt
BAKGRUNN: Migrene er en vanlig nevrologisk sykdom som medfører betydelig belastning for den enkelte som rammes, og store helseøkonomiske kostnader for samfunnet. Migrene er forbundet med økt risiko for hjerneslag. Formålet med denne artikkelen er å gi en oversikt over sammenhengen mellom migrene og hjerneslag: både hjerneinfarkt og hjerneblødning, mulige underliggende mekanismer, kliniske implikasjoner og behovet for videre forskning innen feltet. KUNNSKAPSGRUNNLAG: Denne oversikten er basert på litteratursøk i PubMed med definert søkestreng supplert med et pyramidesøk i søkemotoren McMaster PLUS med ordene «migraine» og «stroke», samt gjennomgang av artiklenes referanselister...
February 20, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Faustine Drahy, Saskia Ingen-Housz-Oro, Sabine Grootenboer-Mignot, Pierre Wolkenstein, Olivier Chosidow
No abstract text is available yet for this article.
February 14, 2018: JAMA Dermatology
Zofia Bakuła, Magdalena Modrzejewska, Lian Pennings, Małgorzata Proboszcz, Aleksandra Safianowska, Jacek Bielecki, Jakko van Ingen, Tomasz Jagielski
Studies on drug susceptibility of Mycobacterium kansasii are very few and involve limited number of strains. The purpose of this study was to determine drug susceptibility profiles of M. kansasii isolates representing a spectrum of species genotypes (subtypes) with two different methodologies, i.e. broth microdilution and E-test assays. To confirm drug resistance, drug target genes were sequenced.A collection of 85 M. kansasii isolates, including representatives of eight different subtypes (I-VI, I/II, IIB) from eight countries was used...
February 5, 2018: Antimicrobial Agents and Chemotherapy
Esther Tijchon, Liesbeth van Emst, Laurensia Yuniati, Dorette van Ingen Schenau, Mylène Gerritsen, Laurens T van der Meer, Owen Williams, Peter M Hoogerbrugge, Blanca Scheijen, Frank N van Leeuwen
Translocation t(12;21) (p13;q22), giving rise to the ETV6-RUNX1 fusion gene, is the most common genetic abnormality in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). This translocation usually arises in utero, but its expression is insufficient to induce leukemia and requires other cooperating genetic lesions for BCP-ALL to develop. Deletions affecting the transcriptional coregulator BTG1 are frequently observed in ETV6-RUNX1-positive leukemia. Here we show that Btg1 deficiency enhances the self-renewal capacity of ETV6-RUNX1 positive mouse fetal liver derived hematopoietic progenitors (FL-HPCs)...
February 2, 2018: Experimental Hematology
R A Haasdijk, J van Ingen
No abstract text is available yet for this article.
January 2018: New Microbes and New Infections
F Poizeau, O Gaudin, L Le Cleach, T A Duong, C Hua, C Hotz, S Ingen-Housz-Oro, E Sbidian, O Zehou, A Colin, N de Prost, B Lebrun-Vignes, O Chosidow, P Wolkenstein, L Fardet
Ciclosporin has shown promising results for mortality in patients with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). However, available studies included only a small number of patients and did not include a validated and homogenous control group. We present the results from a retrospective monocentric study including 174 patients with SJS/TEN during 2005-2016. Among them, 95 received ciclosporin (3 mg/kg/day) plus supportive care and 79 supportive care only. Both a traditional exposed/unexposed method and a propensity-score matching method were used to compare the progression of skin detachment between day 0 and day 5, the proportion of patients with cutaneous re-epithelialization starting on day 5 or mucosal re-epithelialization on day 10, the duration of progression, and the number of deaths between the two groups...
January 21, 2018: Journal of Investigative Dermatology
L V Visseaux, A D Durlach, S B Barete, M B B Beylot-Barry, N B Bonnet, A F C Chassine, N F Franck, G H Herve, C L Leclec'h, L M Machet, S I O Ingen-Housz-Oro, T P Petrella, B V Vergier, N O Ortonne, F G Grange
BACKGROUND: A distinctive eruption referred to as "insect bite-like reaction", or "eosinophilic dermatosis of hematologic malignancy" has been described during the course of hematological B-cell malignancies (BCM). However, its clinical evolution, histopathological features and pathogenesis remain unclear. OBJECTIVES: To characterize this eruption and to investigate its pathogenesis and relationship with the underlying BCM. METHODS: In this multicenter retrospective study of the French Study Group on Cutaneous Lymphomas, 37 patients with a BCM and a cutaneous eruption consisting in chronic and/or recurrent papules, papulo-vesicles and/or nodules were included...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Gerard A Rongen, Iris van Ingen, Marc Kok, Harald Vonkeman, Matthijs Janssen, Tim L Jansen
Vasodilator function is reported to be reduced in rheumatoid arthritis (RA), and is considered an early sign of vascular dysfunction, which is normalised by TNF inhibitors (TNFi). To optimise cost-effectiveness, tapering or interruption of TNFi therapy in established RA patients is advocated. We explored whether cessation of TNFi results in impaired vasodilator function and whether this relates to the development of a Disease Activity Score (DAS28)-based flare. Forty-one patients were assessed for eligibility as RA with at least 12 months of low disease activity (based on 28 joint counts); 35 enrolled into the randomised study: 8 were randomised to continue, 27 to stopping TNFi...
January 7, 2018: Clinical Rheumatology
Julia Sanchez, Saskia Ingen-Housz-Oro, Olivier Chosidow, Frank Antonicelli, Philippe Bernard
No abstract text is available yet for this article.
January 3, 2018: JAMA Dermatology
Reginald V van der Kwast, Eva van Ingen, Laura Parma, Hendrika A Peters, Paul H Quax, A Y Nossent
Rationale: Adenosine-to-inosine (A-to-I) editing of microRNAs has the potential to cause a shift in target-site selection. 2'-O-ribose-methylation (2'OMe) of adenosine residues however, has been shown to inhibit A-to-I-editing. Objective: To investigate whether angiomiR miR487b is subject to A-to-I-editing and/or 2'OMe during neovascularization. Methods and Results: cDNA was prepared from C57BL/6-mice subjected to hindlimb ischemia. Using Sanger-sequencing and endonuclease digestion, we identified and validated A-to-I-editing of the miR487b seed-sequence...
December 28, 2017: Circulation Research
Charles Velter, Claire Hotz, S Ingen-Housz-Oro, Pierre Wolkenstein, Laurence Fardet
No abstract text is available yet for this article.
December 20, 2017: JAMA Dermatology
Faustine Drahy, Claire Hotz, Nicolas Ortonne, Lisa Ghoufi, Sabine Grootenboer-Mignot, Christophe Massard, Marie-Pierre Perrin, Olivier Chosidow, Saskia Ingen-Housz-Oro
No abstract text is available yet for this article.
December 2017: Lancet Oncology
Tullia de Risi-Pugliese, Fleur Cohen Aubart, Julien Haroche, Philippe Moguelet, Sabine Grootenboer-Mignot, Alexis Mathian, Saskia Ingen-Housz-Oro, Miguel Hie, Noémie Wendremaire, Françoise Aucouturier, François Lepelletier, Makoto Miyara, Brigitte Bader-Meunier, Philippe Rémy, Nicole Fabien, Camille Francès, Stéphane Barete, Zahir Amoura
BACKGROUND: Bullous systemic lupus erythematosus (BSLE) is a rare blistering condition associated with systemic lupus erythematosus (SLE). PATIENTS AND METHODS: We conducted a multi-center retrospective study and literature review in order to describe the clinical, immunological, and histological presentations and outcomes of BSLE. The skin biopsies were centrally reviewed, and sera obtained during a flare of BSLE were analyzed for identification of circulating anti-basement membrane zone antibodies...
November 4, 2017: Seminars in Arthritis and Rheumatism
Yuanyuan Qu, Shengnan You, Xuwang Zhang, Xiaofang Pei, Wenli Shen, Zhichao Li, Shuzhen Li, Zhaojing Zhang
A green and eco-friendly method for the synthesis of gold nanoparticles (AuNPs) was developed using the cell-free extracts of a yeast strain Magnusiomyces ingens LH-F1. UV-vis spectra showed a distinct absorption band at ~ 540 nm, corresponding to the surface plasmon resonance of AuNPs. Transmission electron microscopy images revealed that the shapes of AuNPs were almost spherical and pseudo-spherical. Fourier transform infrared spectroscopy and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analyses suggested that some proteins containing amino- and carboxyl-groups in the cell-free extracts were absorbed on the surface of nanoparticles, which could act as reducing and capping agents for AuNPs synthesis...
March 2018: Bioprocess and Biosystems Engineering
F Alcaide, J Amlerová, G Bou, P J Ceyssens, P Coll, D Corcoran, M-S Fangous, I González-Álvarez, R Gorton, G Greub, G Hery-Arnaud, J Hrábak, A Ingebretsen, B Lucey, I Marekoviċ, C Mediavilla-Gradolph, M R Monté, J O'Connor, J O'Mahony, O Opota, B O'Reilly, D Orth-Höller, M Oviaño, J J Palacios, B Palop, A B Pranada, L Quiroga, D Rodríguez-Temporal, M J Ruiz-Serrano, G Tudó, A Van den Bossche, J van Ingen, B Rodriguez-Sanchez
BACKGROUND: The implementation of MALDI-TOF MS for microorganism identification has changed the routine of the microbiology laboratories as we knew it. Most microorganisms can now be reliably identified within minutes using this inexpensive, user-friendly methodology. However, its application in the identification of mycobacteria isolates has been hampered by the structure of their cell wall. Improvements in the sample processing method and in the available database have proved key factors for the rapid and reliable identification of non-tuberculous mycobacteria isolates using MALDI-TOF MS...
November 22, 2017: Clinical Microbiology and Infection
Devy Lu, Camille Hua, Amandine Servy, Francoise Foulet, Francoise Botterel, Nicolas De Prost, Olivier Ellrodt, Berline Sigha, Dragos Popescu, Nicolas Ortonne, Pierre Wolkenstein, Saskia Ingen-Housz-Oro, Olivier Chosidow
No abstract text is available yet for this article.
November 24, 2017: European Journal of Dermatology: EJD
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