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Jan Robert Grøndahl, Øystein Fossdal, Torgeir Hauge-Iversen, Einar Husebye, Elin Olaug Rosvold, Trygve Kongshavn
BAKGRUNN: Hensikten med denne studien var å kartlegge grunnlaget for innleggelser ved en stor medisinsk avdeling i Norge. Vi har vurdert mulige alternativer til innleggelse og hvorvidt triagering kan bidra til å identifisere aktuelle pasienter. MATERIALE OG METODE: Alle innleggelser ved Medisinsk avdeling ved Drammen sykehus i en full uke høsten 2014 ble registrert med pasientens alder, kjønn, liggetid, innleggende lege/instans, hvor vedkommende ble innlagt fra og diagnose ved innleggelse og utskrivning...
May 8, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Sabrin Ibrahim, Gamal Mohamed, Rwaida Al Haidari, Amal El-Kholy, Mohamed Zayed
Background: Marine organisms are established to be a wealthy source of bioactive compounds with diverse chemical structures and bioactivities. Acanthostrongylophora ingens is known to be rich with pyrimidine b-carboline and manzamine-type alkaloids. The goal of the present work is to isolate and identify new alkaloids from A. ingens as well as to assess the cytotoxic potential of these metabolites towards various cancer cell lines. Methods: The crude MeOH extract of the sponge was separated by vacuum liquid chromatography (VLC), using n-hexane , EtOAc, and MeOH...
April 2018: Pharmacognosy Magazine
Jayaseelan Murugaiyan, Astrid Lewin, Elisabeth Kamal, Zofia Bakuła, Jakko van Ingen, Vit Ulmann, Miren J Unzaga Barañano, Joanna Humięcka, Aleksandra Safianowska, Uwe H Roesler, Tomasz Jagielski
Mycobacterium kansasii is an emerging non-tuberculous mycobacterial (NTM) pathogen capable of causing severe lung disease. Of the seven currently recognized M. kansasii genotypes (I-VII), genotypes I and II are most prevalent and have been associated with human disease, whereas the other five (III-VII) genotypes are predominantly of environmental origin and are believed to be non-pathogenic. Subtyping of M. kansasii serves as a valuable tool to guide clinicians in pursuing diagnosis and to initiate the proper timely treatment...
2018: Frontiers in Microbiology
Ketil Lunde, Ahmed Al-Ani, Reidar Bjørnerheim, Anders Hervold, Anders Opdahl, Jan Otto Beitnes
BAKGRUNN: Atrieflimmer er en vanlig tilstand i befolkningen og gir økt risiko for hjerneslag. Antikoagulasjonsbehandling er effektivt for å forebygge tromboembolisme ved atrieflimmer, men av ulike grunner blir mange atrieflimmerpasienter med indikasjon for antikoagulasjonsbehandling ikke behandlet. Kateterbasert lukking av venstre atriums aurikkel er en ny metode for å forebygge hjerneslag ved atrieflimmer. MATERIALE OG METODE: I perioden september 2014-april 2016 gjennomgikk 27 pasienter med atrieflimmer og høy risiko for hjerneslag forsøk på kateterbasert lukking av venstre atriums aurikkel ved Oslo universitetssykehus...
April 17, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
S Ingen-Housz-Oro, T-A Duong, N de Prost, A Colin, L Fardet, B Lebrun-Vignes, A Barbaud, O Chosidow, P Wolkenstein
No abstract text is available yet for this article.
April 13, 2018: Annales de Dermatologie et de Vénéréologie
Marie Beylot-Barry, Diane Mermin, Aline Maillard, Reda Bouabdallah, Nathalie Bonnet, Anne-Bénédicte Duval-Modeste, Laurent Mortier, Saskia Ingen-Housz-Oro, Caroline Ram-Wolff, Stéphane Barete, Stéphane Dalle, Eve Maubec, Gaelle Quereux, Isabelle Templier, Martine Bagot, Florent Grange, Pascal Joly, Béatrice Vergier, Pierre-Julien Vially, Audrey Gros, Anne Pham-Ledard, Eric Frison, Jean-Philippe Merlio
While the combination of rituximab and polychemotherapy has improved prognosis of primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT), advanced age of patients limits therapeutic options in relapsing/refractory cases. A multicenter single-arm phase II trial was conducted to assess benefit and safety of lenalidomide in refractory/relapsing PCDLBCL, LT. Primary endpoint was the 6-month overall response rate (ORR). Secondary endpoints were 12-month ORR, overall and specific survival, duration of response, progression-free survival (PFS), safety and identification of prognostic factors...
March 26, 2018: Journal of Investigative Dermatology
Jakko van Ingen, Timothy Aksamit, Claire Andrejak, Erik C Böttger, Emmanuelle Cambau, Charles L Daley, David E Griffith, Lorenzo Guglielmetti, Steven M Holland, Gwen A Huitt, Won-Jung Koh, Christoph Lange, Philip Leitman, Theodore K Marras, Kozo Morimoto, Kenneth N Olivier, Miguel Santin, Jason E Stout, Rachel Thomson, Enrico Tortoli, Richard J Wallace, Kevin L Winthrop, Dirk Wagner
No abstract text is available yet for this article.
March 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Reyhan Amode, Saskia Ingen-Housz-Oro, Nicolas Ortonne, Touda Bounfour, Sabine Pereyre, Frédéric Schlemmer, Emilie Bequignon, Gérard Royer, Pierre Wolkenstein, Olivier Chosidow
BACKGROUND: Mycoplasma pneumoniae (MP) infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome-toxic epidermal necrosis (SJS-TEN). Clinical aspects of MP-related EM (MP-EM) have been poorly described in the literature. OBJECTIVE: To highlight differences between MP-EM and non-MP-EM. METHODS: This monocenter retrospective cohort study included all the patients admitted for EM from 2000 to 2015 in our dermatology department...
March 17, 2018: Journal of the American Academy of Dermatology
Zofia Bakuła, Anna Brzostek, Paulina Borówka, Anna Żaczek, Izabela Szulc-Kiełbik, Agata Podpora, Paweł Parniewski, Dominik Strapagiel, Jarosław Dziadek, Małgorzata Proboszcz, Jacek Bielecki, Jakko van Ingen, Tomasz Jagielski
Molecular epidemiological studies of Mycobacterium kansasii are hampered by the lack of highly-discriminatory genotyping modalities. The purpose of this study was to design a new, high-resolution fingerprinting method for M. kansasii. Complete genome sequence of the M. kansasii ATCC 12478 reference strain was searched for satellite-like repetitive DNA elements comprising tandem repeats. A total of 24 variable-number tandem repeat (VNTR) loci were identified with potential discriminatory capacity. Of these, 17 were used to study polymorphism among 67 M...
March 13, 2018: Scientific Reports
M Dumas, C Hua, C Hotz, C Velter, T A Duong, T Maraffi, N Ortonne, S Hüe, L Fardet, N de Prost, P Wolkenstein, S Ingen-Housz-Oro, O Chosidow
No abstract text is available yet for this article.
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
E E Becerril-Garcia, D Petatan-Ramirez, I Ortiz-Aguirre, A Ayala-Bocos
This is the first record of the Pacific seahorse Hippocampus ingens at a northern oceanic island from the eastern Pacific Ocean. The photographic record of the juvenile female H. ingens was made in November 2015 during a cage diving trip at Guadalupe Island, Mexico. The presence of H. ingens in this area could be related to long distance dispersal mechanisms, as has been observed in other species of seahorses.
April 2018: Journal of Fish Biology
ShengQi Xiang, Ulric B le Paige, Velten Horn, Klaartje Houben, Marc Baldus, Hugo van Ingen
Chromatin function depends on a dense network of interactions between nucleosomes and a wide range of proteins. A detailed description of these protein-nucleosome interactions is required to reach a full molecular understanding of chromatin function in both genetics and epigenetics. Herein, we show that the structure, dynamics, and interactions of nucleosomes can be interrogated in a residue-specific manner by using state-of-the-art solid-state NMR spectroscopy. Using sedimented nucleosomes, high-resolution spectra were obtained for both flexible histone tails and the non-mobile histone core...
April 16, 2018: Angewandte Chemie
Bendik Slagsvold Winsvold, Annike Marvik, John-Anker Zwart, Anne Hege Aamodt
BAKGRUNN: Migrene er en vanlig nevrologisk sykdom som medfører betydelig belastning for den enkelte som rammes, og store helseøkonomiske kostnader for samfunnet. Migrene er forbundet med økt risiko for hjerneslag. Formålet med denne artikkelen er å gi en oversikt over sammenhengen mellom migrene og hjerneslag: både hjerneinfarkt og hjerneblødning, mulige underliggende mekanismer, kliniske implikasjoner og behovet for videre forskning innen feltet. KUNNSKAPSGRUNNLAG: Denne oversikten er basert på litteratursøk i PubMed med definert søkestreng supplert med et pyramidesøk i søkemotoren McMaster PLUS med ordene «migraine» og «stroke», samt gjennomgang av artiklenes referanselister...
February 20, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Faustine Drahy, Saskia Ingen-Housz-Oro, Sabine Grootenboer-Mignot, Pierre Wolkenstein, Olivier Chosidow
No abstract text is available yet for this article.
April 1, 2018: JAMA Dermatology
Zofia Bakuła, Magdalena Modrzejewska, Lian Pennings, Małgorzata Proboszcz, Aleksandra Safianowska, Jacek Bielecki, Jakko van Ingen, Tomasz Jagielski
Very few studies have examined drug susceptibility of Mycobacterium kansasii , and they involve a limited number of strains. The purpose of this study was to determine drug susceptibility profiles of M. kansasii isolates representing a spectrum of species genotypes (subtypes) with two different methodologies, i.e., broth microdilution and Etest assays. To confirm drug resistance, drug target genes were sequenced. A collection of 85 M. kansasii isolates, including representatives of eight different subtypes (I to VI, I/II, and IIB) from eight countries, was used...
April 2018: Antimicrobial Agents and Chemotherapy
Esther Tijchon, Liesbeth van Emst, Laurensia Yuniati, Dorette van Ingen Schenau, Mylène Gerritsen, Laurens T van der Meer, Owen Williams, Peter M Hoogerbrugge, Blanca Scheijen, Frank N van Leeuwen
Translocation t(12;21) (p13;q22), giving rise to the ETV6-RUNX1 fusion gene, is the most common genetic abnormality in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). This translocation usually arises in utero, but its expression is insufficient to induce leukemia and requires other cooperating genetic lesions for BCP-ALL to develop. Deletions affecting the transcriptional coregulator BTG1 are frequently observed in ETV6-RUNX1-positive leukemia. Here we report that Btg1 deficiency enhances the self-renewal capacity of ETV6-RUNX1-positive mouse fetal liver-derived hematopoietic progenitors (FL-HPCs)...
April 2018: Experimental Hematology
R A Haasdijk, J van Ingen
No abstract text is available yet for this article.
January 2018: New Microbes and New Infections
Florence Poizeau, Olivier Gaudin, Laurence Le Cleach, Tu-Anh Duong, Camille Hua, Claire Hotz, Saskia Ingen-Housz-Oro, Emilie Sbidian, Ouidad Zehou, Audrey Colin, Nicolas de Prost, Bénédicte Lebrun-Vignes, Olivier Chosidow, Pierre Wolkenstein, Laurence Fardet
Cyclosporine has shown promising results for mortality in patients with Stevens-Johnson syndrome/toxic epidermal necrolysis. However, available studies included only a small number of patients and did not include a validated and homogenous control group. We present the results from a retrospective monocentric study including 174 patients with Stevens-Johnson syndrome/toxic epidermal necrolysis during 2005-2016. Among them, 95 received cyclosporine (3 mg/kg/day) plus supportive care, and 79 received supportive care only...
January 31, 2018: Journal of Investigative Dermatology
L Visseaux, A Durlach, S Barete, M Beylot-Barry, N Bonnet, A Chassine, N Franck, G Herve, C Leclec'h, L Machet, S Ingen-Housz-Oro, T Petrella, B Vergier, N Ortonne, F Grange
BACKGROUND: A distinctive eruption referred to as 'insect bite-like reaction' or 'eosinophilic dermatosis of haematological malignancy' has been described during the course of haematological B-cell malignancies (BCM). However, its clinical evolution, histopathological features and pathogenesis remain unclear. OBJECTIVES: To characterize this eruption and to investigate its pathogenesis and relationship with the underlying BCM. METHODS: In this multicenter retrospective study of the French Study Group on Cutaneous Lymphomas, 37 patients with a BCM and a cutaneous eruption consisting in chronic and/or recurrent papules, papulo-vesicles and/or nodules were included...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Gerard A Rongen, Iris van Ingen, Marc Kok, Harald Vonkeman, Matthijs Janssen, Tim L Jansen
Vasodilator function is reported to be reduced in rheumatoid arthritis (RA), and is considered an early sign of vascular dysfunction, which is normalised by TNF inhibitors (TNFi). To optimise cost-effectiveness, tapering or interruption of TNFi therapy in established RA patients is advocated. We explored whether cessation of TNFi results in impaired vasodilator function and whether this relates to the development of a Disease Activity Score (DAS28)-based flare. Forty-one patients were assessed for eligibility as RA with at least 12 months of low disease activity (based on 28 joint counts); 35 enrolled into the randomised study: 8 were randomised to continue, 27 to stopping TNFi...
April 2018: Clinical Rheumatology
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