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https://www.readbyqxmd.com/read/29307093/vasodilator-function-worsens-after-cessation-of-tumour-necrosis-factor-inhibitor-therapy-in-patients-with-rheumatoid-arthritis-only-if-a-flare-occurs
#1
Gerard A Rongen, Iris van Ingen, Marc Kok, Harald Vonkeman, Matthijs Janssen, Tim L Jansen
Vasodilator function is reported to be reduced in rheumatoid arthritis (RA), and is considered an early sign of vascular dysfunction, which is normalised by TNF inhibitors (TNFi). To optimise cost-effectiveness, tapering or interruption of TNFi therapy in established RA patients is advocated. We explored whether cessation of TNFi results in impaired vasodilator function and whether this relates to the development of a Disease Activity Score (DAS28)-based flare. Forty-one patients were assessed for eligibility as RA with at least 12 months of low disease activity (based on 28 joint counts); 35 enrolled into the randomised study: 8 were randomised to continue, 27 to stopping TNFi...
January 7, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29299590/rituximab-as-single-long-term-maintenance-therapy-in-patients-with-difficult-to-treat-pemphigus
#2
Julia Sanchez, Saskia Ingen-Housz-Oro, Olivier Chosidow, Frank Antonicelli, Philippe Bernard
No abstract text is available yet for this article.
January 3, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29284691/a-to-i-editing-of-microrna-487b-alters-target-gene-selection-after-ischemia-and-promotes-neovascularization
#3
Reginald V van der Kwast, Eva van Ingen, Laura Parma, Hendrika A Peters, Paul H Quax, A Y Nossent
Rationale: Adenosine-to-inosine (A-to-I) editing of microRNAs has the potential to cause a shift in target-site selection. 2'-O-ribose-methylation (2'OMe) of adenosine residues however, has been shown to inhibit A-to-I-editing. Objective: To investigate whether angiomiR miR487b is subject to A-to-I-editing and/or 2'OMe during neovascularization. Methods and Results: cDNA was prepared from C57BL/6-mice subjected to hindlimb ischemia. Using Sanger-sequencing and endonuclease digestion, we identified and validated A-to-I-editing of the miR487b seed-sequence...
December 28, 2017: Circulation Research
https://www.readbyqxmd.com/read/29261833/stevens-johnson-syndrome-during-pregnancy-case-report-of-a-newborn-treated-with-the-culprit-drug
#4
Charles Velter, Claire Hotz, S Ingen-Housz-Oro, Pierre Wolkenstein, Laurence Fardet
No abstract text is available yet for this article.
December 20, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29208443/a-polymorphous-bullous-dermatosis
#5
Faustine Drahy, Claire Hotz, Nicolas Ortonne, Lisa Ghoufi, Sabine Grootenboer-Mignot, Christophe Massard, Marie-Pierre Perrin, Olivier Chosidow, Saskia Ingen-Housz-Oro
No abstract text is available yet for this article.
December 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29191376/clinical-histological-immunological-presentations-and-outcomes-of-bullous-systemic-lupus-erythematosus-10-new-cases-and-a-literature-review-of-118-cases
#6
Tullia de Risi-Pugliese, Fleur Cohen Aubart, Julien Haroche, Philippe Moguelet, Sabine Grootenboer-Mignot, Alexis Mathian, Saskia Ingen-Housz-Oro, Miguel Hie, Noémie Wendremaire, Françoise Aucouturier, François Lepelletier, Makoto Miyara, Brigitte Bader-Meunier, Philippe Rémy, Nicole Fabien, Camille Francès, Stéphane Barete, Zahir Amoura
BACKGROUND: Bullous systemic lupus erythematosus (BSLE) is a rare blistering condition associated with systemic lupus erythematosus (SLE). PATIENTS AND METHODS: We conducted a multi-center retrospective study and literature review in order to describe the clinical, immunological, and histological presentations and outcomes of BSLE. The skin biopsies were centrally reviewed, and sera obtained during a flare of BSLE were analyzed for identification of circulating anti-basement membrane zone antibodies...
November 4, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29188359/biosynthesis-of-gold-nanoparticles-using-cell-free-extracts-of-magnusiomyces-ingens-lh-f1-for-nitrophenols-reduction
#7
Yuanyuan Qu, Shengnan You, Xuwang Zhang, Xiaofang Pei, Wenli Shen, Zhichao Li, Shuzhen Li, Zhaojing Zhang
A green and eco-friendly method for the synthesis of gold nanoparticles (AuNPs) was developed using the cell-free extracts of a yeast strain Magnusiomyces ingens LH-F1. UV-vis spectra showed a distinct absorption band at ~ 540 nm, corresponding to the surface plasmon resonance of AuNPs. Transmission electron microscopy images revealed that the shapes of AuNPs were almost spherical and pseudo-spherical. Fourier transform infrared spectroscopy and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analyses suggested that some proteins containing amino- and carboxyl-groups in the cell-free extracts were absorbed on the surface of nanoparticles, which could act as reducing and capping agents for AuNPs synthesis...
November 29, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29174730/how-to-identify-non-tuberculous-mycobacterium-species-by-using-maldi-tof-mass-spectrometry
#8
REVIEW
Fernando Alcaide, J Amlerová, Germán Bou, Pieter-Jan Ceyssens, Pere Coll, Dan Corcoran, Marie-Sarah Fangous, Iván González-Álvarez, Rebecca Gorton, Gilbert Greub, Geneviève Hery-Arnaud, Jaroslav Hrábak, André Ingebretsen, Brigid Lucey, Ivana Marekoviċ, Concepción Mediavilla-Gradolph, James O'Connor, Jim O'Mahony, Onya Opota, Brendan O'Reilly, Dorothea Orth-Höller, Marina Oviaño, Juan José Palacios, Begoña Palop, Arthur Pranada, Lidia Quiroga, David Rodríguez-Temporal, María Jesús Ruiz-Serrano, Griselda Tudó, An van den Bossche, Jakko van Ingen, Belén Rodriguez-Sanchez
BACKGROUND: The implementation of MALDI-TOF MS for microorganism identification has changed the routine of the microbiology laboratories as we knew it. Most microorganisms can now be reliably identified within minutes using this inexpensive, user-friendly methodology. However, its application on the identification of mycobacteria isolates has been hampered by the structure of their cell wall. Improvements in the sample processing method and in the available database have proved key factors for the rapid and reliable identification of non-tuberculous mycobacteria isolates using MALDI-TOF MS AIMS: The main objective is to provide information about the proceedings for the identification of non-tuberculous isolates using MALDI-TOF MS and to review different sample processing methods, available databases and the interpretation of the results...
November 21, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29171398/primary-cutaneous-mucormycosis-as-a-complication-of-erosive-dermatitis-two-cases
#9
Devy Lu, Camille Hua, Amandine Servy, Francoise Foulet, Francoise Botterel, Nicolas De Prost, Olivier Ellrodt, Berline Sigha, Dragos Popescu, Nicolas Ortonne, Pierre Wolkenstein, Saskia Ingen-Housz-Oro, Olivier Chosidow
No abstract text is available yet for this article.
November 24, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29142422/chemotaxonomic-diversity-of-three-ficus-species-their-discrimination-using-chemometric-analysis-and-their-role-in-combating-oxidative-stress
#10
Nawal Al-Musayeib, Sherif S Ebada, Haidy A Gad, Fadia S Youssef, Mohamed Lotfy Ashour
Background: Genus Ficus (Moraceae) constitutes more than 850 species and about 2000 varieties and it acts as a golden mine that could afford effective and safe remedies combating many health disorders. Objectives: Discrimination of Ficus cordata, Ficus ingens, and Ficus palmata using chemometric analysis and assessment of their role in combating oxidative stress. Materials and Methods: Phytochemical profiling of the methanol extracts of the three Ficus species and their successive fractions was performed using high-performance liquid chromatography/electrospray ionization mass spectrometry...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29104441/species-conservation-profiles-of-endemic-spiders-araneae-from-madeira-and-selvagens-archipelagos-portugal
#11
Pedro Cardoso, Luís C Crespo, Isamberto Silva, Paulo Av Borges, Mário Boieiro
Background: The North Atlantic archipelagos of Madeira and Selvagens present a unique biological diversity including, presently, 56 endemic spider species. Several recent projects provide valuable information on their distribution across most islands and habitats. To date, the only endemic spider assessed according to the IUCN Red List criteria is Hogna ingens. The objective of this paper is to assess all remaining endemic species and advise on possible future conservation actions critical for the survival of endangered species...
2017: Biodiversity Data Journal
https://www.readbyqxmd.com/read/29055135/treatment-of-prurigo-with-methotrexate-a-multicenter-retrospective-study-of-39-cases-running-head-treatment-of-prurigo-with-methotrexate
#12
T Klejtman, M Beylot-Barry, P Joly, M A Richard, S Debarbieux, L Misery, P Wolkenstein, O Chosidow, S Ingen-Housz-Oro
BACKGROUND: Prurigo is a common primary pruritic condition. Treatment is challenging. Methotrexate (MTX) is effective for the treatment of pruriginous dermatoses, but its use in prurigo has been little studied. OBJECTIVES: To investigate the efficacy and safety of MTX in the treatment of difficult-to-treat prurigo. METHODS: Patients from six university dermatology departments treated with MTX between 2006 and 2016 for difficult-to-treat prurigo (i...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29045077/subjective-complaints-as-main-reason-for-biosimilar-discontinuation-after-open-label-transitioning-from-originator-to-biosimilar-infliximab
#13
Lieke Tweehuysen, Bart J F van den Bemt, Iris L van Ingen, Alphons J L de Jong, Willemijn H van der Laan, Frank H J van den Hoogen, Alfons A den Broeder
OBJECTIVE: To evaluate drug survival, effectiveness, pharmacokinetics, immunogenicity and safety after transitioning treatment from originator infliximab (Remicade(®) , REM) to biosimilar infliximab (CT-P13) in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis in daily practice. METHODS: 192 of 222 REM-treated patients agreed to transition to CT-P13 and were included in this multicenter prospective cohort study. Change in DAS28-CRP, BASDAI, CRP and (anti-) infliximab levels were assessed after six months and adverse events (AEs) were documented...
October 18, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28982958/the-diagnosis-is-in-the-rings
#14
Saskia Ingen-Housz-Oro, Nicolas Ortonne, Olivier Chosidow
No abstract text is available yet for this article.
October 5, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28972416/new-insights-in-the-treatment-of-nontuberculous-mycobacterial-pulmonary-disease
#15
Mike Marvin Ruth, Jakko van Ingen
No abstract text is available yet for this article.
October 2017: Future Microbiology
https://www.readbyqxmd.com/read/28947034/treatment-and-outcome-of-non-tuberculous-mycobacterial-pulmonary-disease-in-a-predominantly-fibro-cavitary-disease-cohort
#16
Sanne Zweijpfenning, Stephan Kops, Cecile Magis-Escurra, Martin J Boeree, Jakko van Ingen, Wouter Hoefsloot
BACKGROUND: The incidence of non-tuberculous mycobacterial pulmonary disease (NTM-PD) has increased in the Netherlands. The fibro-cavitary disease manifestation predominates, as elsewhere in Europe. We studied treatment and outcome of this disease manifestation, as such data are scarce. METHODS: We conducted a retrospective study of all patients diagnosed with NTM-PD according to the American Thoracic Society statement between 2008 and 2013 in a reference clinic...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28945625/expression-of-tfh-markers-and-detection-of-rhoa-p-g17v-and-idh2-p-r172k-s-mutations-in-cutaneous-localizations-of-angioimmunoblastic-t-cell-lymphomas
#17
Ariane Leclaire Alirkilicarslan, Aurélie Dupuy, Anaïs Pujals, Marie Parrens, Béatrice Vergier, Alistair Robson, Marie-Hélène Delfau-Larue, Saskia Ingen-Housz-Oro, Olivier Chosidow, Corinne Haioun, Marie Beylot-Barry, Jean-Philippe Merlio, Christiane Copie-Bergman, Philippe Gaulard, Nicolas Ortonne
Skin biopsies of 41 angioimmunoblastic T-cell lymphoma patients were retrospectively analyzed for the expression of follicular helper T-cell (TFH) markers, Epstein-Barr virus (EBV), and the presence of RHOA (p.G17V) and IDH2 (p.R172K/S) mutations using allele-specific polymerase chain reaction. We categorized cases into 4 distinctive patterns: (1) low-density lymphocytic perivascular infiltrates (n=11), (2) dense perivascular infiltrates with atypical cells and occasional inflammatory cells (n=13), (3) diffuse infiltrates reminiscent of angioimmunoblastic T-cell lymphoma (n=4), or (4) other aspects (n=13)...
December 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28922812/treatment-of-mycobacterium-avium-intracellulare-complex-a-great-leap-forward
#18
Jan-Willem C Alffenaar, Jakko van Ingen
No abstract text is available yet for this article.
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28886392/how-do-you-define-body-image-exploring-conceptual-gaps-in-understandings-of-body-image-at-an-exercise-facility
#19
K Alysse Bailey, Kimberley L Gammage, Cathy van Ingen
The definition of body image has evolved within research; however, less is known about the layperson's understanding of the construct. This study explored how members and student trainees of an exercise facility (designed for older adults, people with physical disability, and those with cardiac complications) defined body image. Nineteen participants completed a one-on-one interview, and seven of those participants took part in six additional focus group meetings. The following main themes were found: stereotypical assumptions about body image (e...
September 5, 2017: Body Image
https://www.readbyqxmd.com/read/28820087/reinstating-mycobacterium-massiliense-and-mycobacterium-bolletii-as-species-of-the-mycobacterium-abscessus-complex
#20
Toidi Adekambi, Mohamed Sassi, Jakko van Ingen, Michel Drancourt
TheMycobacterium abscessus complex is a group of rapidly growing, multiresistant mycobacteria previously divided into three species. Proposal for the union of Mycobacterium bolletii and Mycobacterium massiliense into one subspecies, so-called M. abscessus subsp. massiliense, created much confusion about the routine identification and reporting of M. abscessus clinical isolates for clinicians. Results derived from multigene sequencing unambiguously supported the reinstatement of M. massiliense and M. bolletii as species, culminating in the presence of erm(41)-encoded macrolide resistance in M...
August 2017: International Journal of Systematic and Evolutionary Microbiology
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