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David Michonneau, Tony Petrella, Nicolas Ortonne, Saskia Ingen-Housz-Oro, Nathalie Franck, Stéphane Barete, Maxime Battistella, Marie Beylot-Barry, Béatrice Vergier, Marc Maynadié, Christine Bodemer, Olivier Hermine, Martine Bagot, Nicole Brousse, Sylvie Fraitag
Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare condition usually considered as favourable. However, it is not known whether polychemotherapy or immunosuppressive-based therapy is the best approach for treating SPTCL. Using data collected between 2000 and 2012 in France, we analysed clinical, biological and pathological data of 27 patients with SPTCL. Medical history revealed that 40% of patients had been previously diagnosed with an autoimmune disorder and 22% with inflammatory panniculitis...
October 10, 2016: Acta Dermato-venereologica
C Isnard, S Ingen-Housz-Oro, L Fardet, E Matteodo, S Duval, F Hemery, M Khellaf, T-A Duong, O Chosidow, P Wolkenstein
BACKGROUND: Our dermatological department includes a dermatological emergency unit (DEU) whose activity has grown in recent years. OBJECTIVES: An audit to characterize the activity of our DEU and its evolution in terms of medical demographics of the area. METHODS: We collected the following data from administrative services: number of patients consulting each year in the DEU and in the general emergency unit (GEU) of our hospital between 2008 and 2014; daily and seasonal activity of the DEU; occurrence of a second event in the department and proportion of patients from the DEU who were hospitalized and why...
September 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Gijs van Ingen, Jin Li, André Goedegebure, Rahul Pandey, Yun Rose Li, Michael E March, Vincent W V Jaddoe, Marina Bakay, Frank D Mentch, Kelly Thomas, Zhi Wei, Xiao Chang, Heather S Hain, André G Uitterlinden, Henriette A Moll, Cornelia M van Duijn, Fernando Rivadeneira, Hein Raat, Robert J Baatenburg de Jong, Patrick M Sleiman, Marc P van der Schroeff, Hakon Hakonarson
Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, Pmeta=2.15 × 10(-09)), and show that the associated variants are correlated with the methylation status of the FNDC1 gene (cg05678571, P=1.43 × 10(-06)), and further show it is an eQTL for FNDC1 (P=9...
September 28, 2016: Nature Communications
G A Rongen, I Van Ingen, T L Jansen
No abstract text is available yet for this article.
October 6, 2016: Clinical Therapeutics
R Karkouche, C Bernigaud, J Fontugne, O Zehou, G Bellaud, M N'Diaye, K Cherif, P Wolkenstein, O Chosidow, N Ortonne, S Ingen-Housz-Oro
BACKGROUND: Equestrian cold panniculitis has been described since 1980 in horse riders or in stable employees. Histological aspect is underdescribed. PATIENTS AND METHODS: We describe clinical and histological features of 6 horse riding or stable employees patients presenting with upper lateral thigh lesions during the winter months between 2014 and 2016 in our dermatological department. RESULTS: Six horse riding or stable employees ladies without any known disease presented with similar symptoms...
September 16, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
N At van der Maas, R Donken, M J M Te Wierik, C M Swaan, S J M Hahne, H E de Melker
INTRODUCTION: Despite sustained high vaccination coverage and a national guideline by the Health Council (HC-guideline) on tetanus postexposure prophylaxis (T-PEP), tetanus sporadically occurs in the Netherlands. This study aims to assess the added value of a bedside test for tetanus immunity (Tetanos Quick Stick (TQS); Ingen BioSciences Group, France), in the context of routine T-PEP in two adult cohorts: those born before introduction of tetanus toxoid vaccination in the National Immunization Programme (NIP) in 1957 (pre-NIP-cohort; n=196) and those born after (NIP-cohort; n=405)...
September 8, 2016: Emergency Medicine Journal: EMJ
Sabrin R M Ibrahim, Gamal A Mohamed
A new β-carboline alkaloid ingenine E (4), along with three known metabolites annomontine (1), acanthomine A (2), and 1,2,3,4-tetrahydronorharman-1-one (3) were isolated from the Indonesian marine sponge Acanthostrongylophora ingens. Their structure characterization was unequivocally carried out using one- and two-dimensional NMR spectroscopy, as well as high-resolution mass spectrometry. The cytotoxic activity of the isolated compounds was evaluated toward MCF7, A549, HCT116, PC12, and Hela cancer cell lines...
September 2, 2016: Journal of Asian Natural Products Research
K Alysse Bailey, Kimberley L Gammage, Cathy van Ingen, David S Ditor
PURPOSE: This narrative explores the lived experience of a young woman, Rebecca, and her transitioned body image after sustaining and being treated for a spinal cord injury. METHOD: Data were collected from a single semi-structured in-depth interview. RESULTS: Rebecca disclosed her transitioned body image experiences after sustaining a spinal cord injury and being treated by medical staff immediately following her injury. Before her injury, she described a holistic body experience and named this experience her "temple"...
August 24, 2016: Disability and Rehabilitation
Blaine A Mathison, Henry S Bishop, Chad R Sanborn, Samaly Dos Santos Souza, Richard Bradbury
A case of acanthocephaliasis in an 18-month-old child caused by Macracanthorhynchus ingens is reported from Florida. This represents only the third documented case of this species in a human host. An overview of human cases of acanthocephaliasis in the literature is presented, along with a review of the biology, clinical manifestations and pathology in the human host, morphology, and diagnosis.
August 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Laurens T van der Meer, Samantha Y A Terry, Dorette van Ingen Schenau, Kiki C Andree, Gerben M Franssen, Debbie M Roeleveld, Bart M Metselaar, Thomas Reinheckel, Peter M Hoogerbrugge, Otto C Boerman, Frank N van Leeuwen
: The antileukemic drug asparaginase, a key component in the treatment of acute lymphoblastic leukemia, acts by depleting asparagine from the blood. However, little is known about its pharmacokinetics and mechanisms of therapy resistance are poorly understood. Here, we explored the in vivo biodistribution of radiolabeled asparaginase, using a combination of in vivo imaging and biochemical techniques, and provide evidence for tissue specific clearance mechanisms, which could reduce effectiveness of the drug at these specific sites...
August 4, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Rafael V Nunes, Fernando Z Vaz-de-Mello
Five species groups of Dichotomius (Selenocopris) are defined and separated in an illustrated key in the first effective attempt of systematization of the subgenus. Four new brachypterous species of Selenocopris are described and the also brachypterous Dichotomius ingens (Luederwaldt) is redescribed. These species are diagnosed, illustrated and assigned to the quadraticeps species group. Taxonomic issues on the subgenus are discussed.
2016: Zootaxa
Carlijn M P le Clercq, Gijs van Ingen, Liesbet Ruytjens, Marc P van der Schroeff
OBJECTIVE: Exposure to loud music has increased significantly because of the current development of personal music players and mobile phones. The aim of this study was to provide an overview of music-induced hearing loss and its symptoms in children. DATA SOURCES: The search was performed in the databases Embase, Medline (OvidSP), Web-of-science, Scopus, Cinahl, Cochrane, PubMed publisher, and Google Scholar. Only articles written in English were included. STUDY SELECTION: Articles describing hearing levels and music exposure in children were used, published from 1990 until April 2015...
October 2016: Otology & Neurotology
Michael J Thomas, Robert P Creed, James Skelton, Bryan L Brown
Animal fitness is influenced by diverse assemblages of internal and external symbionts. These assemblages often change throughout host ontogeny, but the mechanisms that underlie these changes and their consequences for host fitness are seldom revealed. Here we examine a cleaning symbiosis between crayfish and an assemblage of ectosymbiotic branchiobdellidan worms to uncover what mechanisms drive changes in symbiont composition during host ontogeny and the consequences of these changes for both the host and symbionts...
June 2016: Ecology
Beatriz E Ferro, Shashikant Srivastava, Devyani Deshpande, Jotam G Pasipanodya, Dick van Soolingen, Johan W Mouton, Jakko van Ingen, Tawanda Gumbo
In a hollow-fiber model, we mimicked the drug exposures achieved in the lungs of humans treated with standard amikacin, clarithromycin, and cefoxitin combination therapy for Mycobacterium abscessus infection. At optimal dosing, a kill rate of -0.09 (95% confidence interval, -0.04 to 0.03) log10 CFU per ml/day was achieved over the first 14 days, after which there was regrowth due to acquired drug resistance. Thus, the standard regimen quickly failed. A new regimen is needed.
October 2016: Antimicrobial Agents and Chemotherapy
Heyi Zhang, Hugo van Ingen
Proteins come together in macromolecular assemblies, recognizing and binding to each other through their structures, and operating on their substrates through their motions. Detailed characterization of these processes is particularly suited to NMR, a high-resolution technique sensitive to structure, dynamics, and interactions. Advances in isotope-labeling have enabled such studies to an ever-increasing range of systems. Here we highlight recent applications and bring to the fore the range of options to produce labeled proteins and to control the specific placement of isotopes...
June 2016: Current Opinion in Structural Biology
Amélie Beaudet, Jean Dumoncel, John Francis Thackeray, Laurent Bruxelles, Benjamin Duployer, Christophe Tenailleau, Lunga Bam, Jakobus Hoffman, Frikkie de Beer, José Braga
Despite the abundance of cercopithecoids in the fossil record, especially in South Africa, and the recent development of morphometric approaches, uncertainties regarding the taxonomic identification of isolated cranio-dental specimens remain. Because cercopithecoids, nearly always found in stratigraphic association with hominin remains in Plio-Pleistocene deposits, are considered as sensitive ecological and chronological biomarkers, a significant effort should be made to clarify their palaeobiodiversity by assessing additional reliable morphological diagnostic criteria...
June 2016: Journal of Human Evolution
Dominik Strapagiel, Paulina Borówka, Błażej Marciniak, Zofia Bakuła, Jakko van Ingen, Aleksandra Safianowska, Anna Brzostek, Jarosław Dziadek, Tomasz Jagielski
Mycobacterium kansasii belongs to the nontuberculous mycobacteria (NTM) and causes opportunistic infections with both pulmonary and extrapulmonary manifestations. Here, we report the draft genome sequences of six environmental M. kansasii strains, designated 1010001495 (type I), 1010001469 (type II), 1010001468 (type III), 1010001458 (type IV), 1010001454 (type V), and 1010001493 (type V), originally isolated in five different European countries.
2016: Genome Announcements
Kim van Eck, Dirk Faro, Melanie Wattenberg, Arjan de Jong, Saskia Kuipers, Jakko van Ingen
We have assessed matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) identification (Bruker) of nontuberculous mycobacteria from newly positive liquid cultures of respiratory samples. Twelve (22%) of 54 isolates were identified directly from liquid medium. After subculture and with manual laser operation, this rose to 49/54 isolates (91%). MALDI-TOF MS is less promising than previously suggested.
July 2016: Journal of Clinical Microbiology
K Kuipers, D A Diavatopoulos, F van Opzeeland, E Simonetti, C H van den Kieboom, M Kerstholt, M Borczyk, D van Ingen Schenau, E T Brandsma, M G Netea, M I de Jonge
For many bacterial respiratory infections, development of (severe) disease is preceded by asymptomatic colonization of the upper airways. For Streptococcus pneumoniae, the transition to severe lower respiratory tract infection is associated with an increase in nasopharyngeal colonization density. Insight into how the mucosal immune system restricts colonization may provide new strategies to prevent clinical symptoms. Several studies have provided indirect evidence that the mucosal adjuvant Cholera Toxin subunit B (CTB) may confer non-specific protection against respiratory infections...
April 24, 2016: Journal of Infectious Diseases
Janine Wechsler, Saskia Ingen-Housz-Oro, Cristina Socolovschi, Nicolas Ortonne
No abstract text is available yet for this article.
April 19, 2016: American Journal of Dermatopathology
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