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https://www.readbyqxmd.com/read/28729096/can-the-presence-of-a-surrounding-endometrium-differentiate-eccentrically-located-intrauterine-pregnancy-from-interstitial-ectopic-pregnancy
#1
Allison Grant, Ally Murji, Mostafa Atri
OBJECTIVES: Differentiation of an eccentric intrauterine pregnancy (IUP) from an interstitial ectopic pregnancy (EP) is challenging. No sign for differentiation is reported. The purpose of this study was to determine whether the presence of surrounding endometrium (SE) can distinguish eccentric IUP from interstitial EP. METHODS: This study was approved by the institutional ethics board; consent acquisition was waived. Cases were identified using ultrasound (US) reports that included the words "interstitial," "cornual," and "angular...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28547563/poor-adherence-to-national-clinical-management-guidelines-a-population-based-cross-sectional-study-of-the-surgical-management-of-melanoma-in-new-south-wales-australia
#2
Alexander H R Varey, Christine M Madronio, Anne E Cust, Chris Goumas, Graham J Mann, Bruce K Armstrong, Richard A Scolyer, Austin M Curtin, John F Thompson
BACKGROUND: Standardization of the clinical management of melanoma through the formulation of national guidelines, based on interpretation of the existing evidence and consensus expert opinion, seeks to improve quality of care; however, adherence to national guidelines has not been well studied. METHODS: A population-based, cross-sectional study of the clinical management of all patients with newly notified primary melanomas in the state of New South Wales, Australia, during 2006/2007 was conducted using cancer registry identification and questionnaires completed by treating physicians...
August 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28433727/superficial-swab-versus-deep-tissue-biopsy-for-the-microbiological-diagnosis-of-local-infection-in-advanced-stage-pressure-ulcers-of-spinal-cord-injured-patients-a-prospective-study
#3
Sara Tedeschi, Luca Negosanti, Rossella Sgarzani, Filippo Trapani, Salvatore Pignanelli, Micaela Battilana, Rita Capirossi, Donatella Brillanti Ventura, Maddalena Giannella, Michele Bartoletti, Fabio Tumietto, Francesco Cristini, Pierluigi Viale
OBJECTIVE: To assess the predictive value of superficial ulcer swab culture to make a microbiological diagnosis of deep wound infections in spinal cord injury (SCI) patients with advanced-stage pressure ulcers (PU). METHODS: From July 2011 to February 2014, we performed a prospective, single-centre study on adult SCI patients undergoing scheduled surgical debridement and reconstruction for advanced-stage PU, at Montecatone Rehabilitation Institute, a 150-bed hospital dedicated to SCI care...
April 19, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28405501/pdl1-expression-is-a-poor-prognosis-factor-in-soft-tissue-sarcomas
#4
François Bertucci, Pascal Finetti, Delphine Perrot, Agnès Leroux, Françoise Collin, Axel Le Cesne, Jean-Michel Coindre, Jean-Yves Blay, Daniel Birnbaum, Emilie Mamessier
Soft-tissue sarcomas (STS) are a group of rare, heterogeneous, and aggressive tumors, with high metastatic risk and relatively few efficient systemic therapies. In the quest for new treatments, the immune system represents an attractive therapeutic target. Recently, PD1/PDL1 inhibitors showed very promising results in patients with solid tumors. PDL1 expression has been rarely studied in STS, in small series only, by using immunohistochemistry (IHC), and with non-concordant prognostic implications. Here, we have analyzed PDL1 mRNA expression in 758 clinical STS samples retrospectively profiled using DNA microarrays and RNAseq, and searched for correlations with clinicopathological variables including metastasis-free survival (MFS) after surgery...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28286183/ordering-the-mob-insights-into-replicon-and-mob-typing-schemes-from-analysis-of-a-curated-dataset-of-publicly-available-plasmids
#5
Alex Orlek, Hang Phan, Anna E Sheppard, Michel Doumith, Matthew Ellington, Tim Peto, Derrick Crook, A Sarah Walker, Neil Woodford, Muna F Anjum, Nicole Stoesser
Plasmid typing can provide insights into the epidemiology and transmission of plasmid-mediated antibiotic resistance. The principal plasmid typing schemes are replicon typing and MOB typing, which utilize variation in replication loci and relaxase proteins respectively. Previous studies investigating the proportion of plasmids assigned a type by these schemes ('typeability') have yielded conflicting results; moreover, thousands of plasmid sequences have been added to NCBI in recent years, without consistent annotation to indicate which sequences represent complete plasmids...
May 2017: Plasmid
https://www.readbyqxmd.com/read/28279887/evaluation-of-percutaneous-vacuum-assisted-intact-specimen-breast-biopsy-device-for-ultrasound-visualized-breast-lesions-upstage-rates-and-long-term-follow-up-for-high-risk-lesions-and-dcis
#6
Cathy L Graham
OBJECTIVE: Percutaneous core biopsy of ultrasound visualized breast lesions is standard for diagnosis. Large gauge vacuum-assisted core needles have improved accuracy; but a significant underestimation of malignancy remains. The Intact(R) device was assessed for upstaging and subsequent malignancy at the biopsy site. METHODS: 469 consecutive ultrasound visualized breast lesions, < 2.0 cm in size, BIRADS 4 or 5, biopsied with Intact(R) Breast Lesion Excision System, between July 2007 and August 2014, were reviewed...
March 6, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28278000/successful-outpatient-management-of-lymphoedema-and-lymphorrhoea-with-wrap-around-compression-a-case-study
#7
L Patullo, S Rajagopalan
Referral to specialist centres for treatment of lymphoedema can often have long waiting times. Management of a patient with massive lymphoedema and lymphorrhoea was provided in a vascular outpatient setting. A new form of compression using a wraparound system was used for the management (Juxta-Fit, Medi UK). Despite having previously been non-concordant with treatment options, the patient was independent with product use. Lymphorrhoea ceased and there was a marked decrease in girth size. The patient's quality of life improved and maintenance treatment was provided...
March 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28271401/variants-of-the-eaat2-glutamate-transporter-gene-promoter-are-associated-with-cerebral-palsy-in-preterm-infants
#8
Shavanthi Rajatileka, David Odd, Matthew T Robinson, Alexandra C Spittle, Louis Dwomoh, Maggie Williams, David Harding, Miles Wagstaff, Marie Owen, Charlene Crosby, Jared Ching, Elek Molnár, Karen Luyt, Anikó Váradi
Preterm delivery is associated with neurodevelopmental impairment caused by environmental and genetic factors. Dysfunction of the excitatory amino acid transporter 2 (EAAT2) and the resultant impaired glutamate uptake can lead to neurological disorders. In this study, we investigated the role of single nucleotide polymorphisms (SNPs; g.-200C>A and g.-181A>C) in the EAAT2 promoter in susceptibility to brain injury and neurodisability in very preterm infants born at or before 32-week gestation. DNA isolated from newborns' dried blood spots were used for pyrosequencing to detect both SNPs...
March 7, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28152917/nci-community-cancer-center-program-ncccp-disparities-in-time-between-cancer-diagnosis-and-treatment-initiation
#9
Pamela Spain, Michael T Halpern, Kathleen M Castro, Irene Prabhu Das, Brenda A Adjei, Steven Clauser
279 Background: The National Cancer Institute Community Cancer Centers Program (NCCCP) was designed to improve care and reduce cancer disparities at community hospitals. This study examined the number of days between diagnosis and treatment for five National Quality Forum-endorsed cancer quality measures. METHODS: A retrospective analysis of data from patients diagnosed and receiving breast or colon cancer treatment at 12 NCCCP sites was performed. We examined time to treatment for cancer quality measures, stratified by concordant and non-concordant patients...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28118522/lack-of-concordance-in-inter-rater-scoring-of-the-provider-s-global-assessment-of-children-with-juvenile-idiopathic-arthritis-with-low-disease-activity
#10
Janalee Taylor, Edward H Giannini, Daniel J Lovell, Bin Huang, Esi Morgan
OBJECTIVE: To measure agreement among raters when scoring the physician/provider global assessment (PGA) of disease activity in patients with juvenile idiopathic arthritis (JIA) with no apparent disease activity, and to identify clinical and laboratory parameters that most strongly influence provider scoring of the PGA. METHODS: Profiles of clinical and laboratory findings from 20 patients with JIA with no apparent disease activity were given to 51 providers who were asked to score the PGA using a 21-circle VAS (range 0 - 10)...
January 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28113282/on-the-influence-of-heart-rate-and-coupling-interval-prematurity-on-heart-rate-turbulence
#11
Oscar Barquero-Perez, Carlos Figuera, Rebeca Goya-Esteban, Inmaculada Mora-Jimenez, Francisco Javier Gimeno-Blanes, Pablo Laguna, Juan Pablo Martinez Cortes, Eduardo Gil, Leif Sornmo, Arcadi Garcia-Alberola, Jose Luis Rojo-Alvarez
OBJECTIVE: Heart rate turbulence (HRT) has been successfully explored for cardiac risk stratification. While HRT is known to be influenced by the heart rate (HR) and the coupling interval (CI), non-concordant results have been reported on how the CI influences HRT. The purpose of this study is to investigate HRT changes in terms of CI and HR by means of a specially designed protocol. METHODS: A dataset was acquired from 11 patients with structurally normal hearts for which CI was altered by different pacing trains and HR by isoproterenol during electrophysiological study (EPS)...
April 15, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27999034/sustained-impact-of-a-computer-assisted-antimicrobial-stewardship-intervention-on-antimicrobial-use-and-length-of-stay
#12
Vincent Nault, Jacques Pepin, Mathieu Beaudoin, Julie Perron, Jean-Marie Moutquin, Louis Valiquette
Objectives: : Prospective audit and feedback interventions are the core components of an antimicrobial stewardship programme. Herein, we describe the sustained impact of an antimicrobial stewardship programme, based on a novel clinical decision-support system (Antimicrobial Prescription Surveillance System; APSS), on antimicrobial use and costs, hospital length of stay (LOS) in days and the proportion of inappropriate antimicrobial prescriptions. Methods: A quasi-experimental, retrospective study was conducted using interrupted time series between 2008 and 2013...
March 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27924175/serum-free-light-chain-assay-and-%C3%AE%C2%BA-%C3%AE-ratio-performance-in-patients-with-monoclonal-gammopathy-high-false-negative-rate-for-%C3%AE%C2%BA-%C3%AE-ratio
#13
Gurmukh Singh
BACKGROUND: Serum free light chain assay (SFLCA) and κ/λ ratio, and protein electrophoretic methods are used in the diagnosis and monitoring of monoclonal gammopathies. METHODS: Results for serum free light chains, serum and urine protein electrophoreses and immunofixation electrophoreses in 468 patients with a diagnosis of monoclonal gammopathy were compared. The results of the two methods were graded as concordant, non-concordant or discordant with the established diagnoses to assess the relative performance of the methods...
January 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27878846/are-the-classic-signs-of-infection-in-concordance-with-results-from-percutaneous-aspiration-to-diagnose-infection-in-pressure-injuries
#14
Joan Blanco-Blanco, Montserrat Gea-Sánchez, Francesc Valenzuela-Pascual, Eva Barallat-Gimeno, Anna Espart, Miguel Ángel Escobar-Bravo
AIM: To explore the concordance between the presence of classic signs of infection and the positive diagnosis identified by the microbiological culture of fluid collected by percutaneous aspiration. BACKGROUND: The classic signs of infection are commonly applied in some contexts to confirm infection in pressure injuries, but its accuracy has been questioned in chronic wounds. Little is known about the concordance of this method with others, such as the deep fluid culture from pressure injuries collected by percutaneous aspiration...
June 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27510520/accuracy-of-classification-of-invasive-lobular-carcinoma-on-needle-core-biopsy-of-the-breast
#15
MULTICENTER STUDY
Kalnisha Naidoo, Brooke Beardsley, Pauline J Carder, Rahul Deb, David Fish, Anne Girling, Sally Hales, Miles Howe, Laura M Wastall, Sally Lane, Andrew H S Lee, Marianna Philippidou, Cecily Quinn, Tim Stephenson, Sarah E Pinder
Although the UK National Institute for Health and Care Excellence guidelines recommend that in patients with biopsy-proven invasive lobular carcinoma (ILC), preoperative MRI scan is considered, the accuracy of diagnosis of ILC in core biopsy of the breast has not been previously investigated. Eleven pathology laboratories from the UK and Ireland submitted data on 1112 cases interpreted as showing features of ILC, or mixed ILC and IDC/no special type (NST)/other tumour type, on needle core biopsy through retrieval of histology reports...
December 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27508786/-op-6c-04-predictors-of-drug-non-adherence-in-out-patients-of-a-university-hospital-urinary-drug-detection-vs-morisky-4-items-questionnaire
#16
I Hamdidouche, V Jullien, P Boutouyrie, E Billaud, M Azizi, S Laurent
OBJECTIVE: Suboptimal drug adherence may prove to be the greatest barrier to the effectiveness of antihypertensive agents (AHT). Thanks to LC-MS/MS technology, urinary drug detection (UDD) may represent an important advancement to monitor non-adherence in routine clinical practice. Our aim was to assess drug adherence by UDD and compare it to the 4-item Morisky Medication Adherence Scale (MMAS-4). DESIGN AND METHOD: 169 patients (68 ± 11 yrs, 58 % women) with primary hypertension followed in the out-patient clinic of a university hospital were included...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27458682/the-role-of-siscom-in-preoperative-evaluation-for-patients-with-epilepsy-surgery-a-meta-analysis
#17
Tong Chen, Liang Guo
PURPOSE: To assess the specific value of subtraction ictal and inter-ictal SPECT co-registered to MRI (SISCOM) in identifying the epileptogenic zone (EZ) and predicting postoperative outcomes in epileptic surgical patients. METHOD: A meta-analysis of studies published from January 1995 to June 2015 was conducted through a comprehensive literature search, and 11 studies were included. R software was first used to calculate a pooled positive rate, concordant rate and positive predictive value (PPV) for good outcomes...
October 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27264990/within-subject-non-concordance-of-abdominal-v-general-high-adiposity-definition-and-analysis-issues
#18
Pierre Traissac, Rebecca Pradeilles, Jalila El Ati, Hajer Aounallah-Skhiri, Agnès Gartner, Francis Delpeuch
No abstract text is available yet for this article.
August 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27232766/preoperative-evaluation-using-magnetoencephalography-experience-in-382-epilepsy-patients
#19
I A Nissen, C J Stam, J Citroen, J C Reijneveld, A Hillebrand
OBJECTIVE: Identifying epilepsy patients for whom clinical MEG is likely to be beneficial avoids or optimizes burdensome ancillary investigations. We determined whether it could be predicted upfront if MEG would be able to generate a hypothesis about the location of the epileptogenic zone (EZ), and in which patients MEG fails to do so. METHODS: MEG recordings of 382 epilepsy patients with inconclusive findings regarding EZ localization prior to MEG were acquired for preoperative evaluation...
August 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27180257/a-sign-of-the-times-to-have-or-to-be-social-capital-or-social-cohesion
#20
Maria A Carrasco, Usama Bilal
Among various social factors associated with health behavior and disease, social cohesion has not captured the imagination of public health researchers as much as social capital as evidenced by the subsuming of social cohesion into social capital and the numerous studies analyzing social capital and the comparatively fewer articles analyzing social cohesion and health. In this paper we provide a brief overview of the evolution of the conceptualization of social capital and social cohesion and we use philosopher Erich Fromm's distinction between "having" and "being" to understand the current research focus on capital over cohesion...
June 2016: Social Science & Medicine
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