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Vincent Nault, Jacques Pepin, Mathieu Beaudoin, Julie Perron, Jean-Marie Moutquin, Louis Valiquette
OBJECTIVES: Prospective audit and feedback interventions are the core components of an antimicrobial stewardship programme. Herein, we describe the sustained impact of an antimicrobial stewardship programme, based on a novel clinical decision-support system (Antimicrobial Prescription Surveillance System; APSS), on antimicrobial use and costs, hospital length of stay (LOS) in days and the proportion of inappropriate antimicrobial prescriptions. METHODS: A quasi-experimental, retrospective study was conducted using interrupted time series between 2008 and 2013...
December 20, 2016: Journal of Antimicrobial Chemotherapy
Gurmukh Singh
BACKGROUND: Serum free light chain assay (SFLCA) and κ/λ ratio, and protein electrophoretic methods are used in the diagnosis and monitoring of monoclonal gammopathies. METHODS: Results for serum free light chains, serum and urine protein electrophoreses and immunofixation electrophoreses in 468 patients with a diagnosis of monoclonal gammopathy were compared. The results of the two methods were graded as concordant, non-concordant or discordant with the established diagnoses to assess the relative performance of the methods...
January 2017: Journal of Clinical Medicine Research
Joan Blanco-Blanco, Montserrat Gea-Sánchez, Francesc Valenzuela-Pascual, Eva Barallat-Gimeno, Anna Espart, Miguel Ángel Escobar-Bravo
AIM: To explore the concordance between the presence of classic signs of infection and the positive diagnosis identified by the microbiological culture of fluid collected by percutaneous aspiration. BACKGROUND: The classic signs of infection are commonly applied in some contexts to confirm infection in pressure injuries, but its accuracy has been questioned in chronic wounds. Little is known about the concordance of this method with others, such as the deep fluid culture from pressure injuries collected by percutaneous aspiration...
November 23, 2016: Journal of Advanced Nursing
Kalnisha Naidoo, Brooke Beardsley, Pauline J Carder, Rahul Deb, David Fish, Anne Girling, Sally Hales, Miles Howe, Laura M Wastall, Sally Lane, Andrew H S Lee, Marianna Philippidou, Cecily Quinn, Tim Stephenson, Sarah E Pinder
Although the UK National Institute for Health and Care Excellence guidelines recommend that in patients with biopsy-proven invasive lobular carcinoma (ILC), preoperative MRI scan is considered, the accuracy of diagnosis of ILC in core biopsy of the breast has not been previously investigated. Eleven pathology laboratories from the UK and Ireland submitted data on 1112 cases interpreted as showing features of ILC, or mixed ILC and IDC/no special type (NST)/other tumour type, on needle core biopsy through retrieval of histology reports...
December 2016: Journal of Clinical Pathology
I Hamdidouche, V Jullien, P Boutouyrie, E Billaud, M Azizi, S Laurent
OBJECTIVE: Suboptimal drug adherence may prove to be the greatest barrier to the effectiveness of antihypertensive agents (AHT). Thanks to LC-MS/MS technology, urinary drug detection (UDD) may represent an important advancement to monitor non-adherence in routine clinical practice. Our aim was to assess drug adherence by UDD and compare it to the 4-item Morisky Medication Adherence Scale (MMAS-4). DESIGN AND METHOD: 169 patients (68 ± 11 yrs, 58 % women) with primary hypertension followed in the out-patient clinic of a university hospital were included...
September 2016: Journal of Hypertension
Tong Chen, Liang Guo
PURPOSE: To assess the specific value of subtraction ictal and inter-ictal SPECT co-registered to MRI (SISCOM) in identifying the epileptogenic zone (EZ) and predicting postoperative outcomes in epileptic surgical patients. METHOD: A meta-analysis of studies published from January 1995 to June 2015 was conducted through a comprehensive literature search, and 11 studies were included. R software was first used to calculate a pooled positive rate, concordant rate and positive predictive value (PPV) for good outcomes...
October 2016: Seizure: the Journal of the British Epilepsy Association
Pierre Traissac, Rebecca Pradeilles, Jalila El Ati, Hajer Aounallah-Skhiri, Agnès Gartner, Francis Delpeuch
No abstract text is available yet for this article.
August 2016: British Journal of Nutrition
I A Nissen, C J Stam, J Citroen, J C Reijneveld, A Hillebrand
OBJECTIVE: Identifying epilepsy patients for whom clinical MEG is likely to be beneficial avoids or optimizes burdensome ancillary investigations. We determined whether it could be predicted upfront if MEG would be able to generate a hypothesis about the location of the epileptogenic zone (EZ), and in which patients MEG fails to do so. METHODS: MEG recordings of 382 epilepsy patients with inconclusive findings regarding EZ localization prior to MEG were acquired for preoperative evaluation...
August 2016: Epilepsy Research
Maria A Carrasco, Usama Bilal
Among various social factors associated with health behavior and disease, social cohesion has not captured the imagination of public health researchers as much as social capital as evidenced by the subsuming of social cohesion into social capital and the numerous studies analyzing social capital and the comparatively fewer articles analyzing social cohesion and health. In this paper we provide a brief overview of the evolution of the conceptualization of social capital and social cohesion and we use philosopher Erich Fromm's distinction between "having" and "being" to understand the current research focus on capital over cohesion...
June 2016: Social Science & Medicine
María Crespo, M M Gómez
BACKGROUND: The present study aims to analyze diagnostic concordance between the DSM-IV and the DSM-5 for posttraumatic stress disorder (PTSD) diagnostic criteria and their different groups of symptoms. Furthermore, analyses are conducted to establish the features of participants with no concordant diagnoses. METHOD: The study assessed 166 people over 18 who had experienced at least one traumatic event. PTSD diagnosis was established using the Global Scale for Posttraumatic Stress (EGEP), a self-report measure to assess PTSD...
May 2016: Psicothema
Oscar Barquero-Perez, Carlos Figuera, Rebeca Goya-Esteban, Inmaculada Mora-Jimenez, Francisco Javier Gimeno-Blanes, Pablo Laguna, Juan Pablo Martinez Cortes, Eduardo Gil, Leif Sornmo, Arcadi Garcia-Alberola, Jose Luis Rojo-Alvarez
OBJECTIVE: Heart rate turbulence (HRT) has been successfully explored for cardiac risk stratification. While HRT is known to be influenced by the heart rate (HR) and the coupling interval (CI), non-concordant results have been reported on how the CI influences HRT. The purpose of this study is to investigate HRT changes in terms of CI and HR by means of a specially designed protocol. METHODS: A dataset was acquired from 11 patients with structurally normal hearts for which CI was altered by different pacing trains and HR by isoproterenol during electrophysiological study (EPS)...
April 15, 2016: IEEE Transactions on Bio-medical Engineering
Haitham S Al Ashry, George Mansour, Andre C Kalil, Ryan W Walters, Renuga Vivekanandan
BACKGROUND: Pneumonia increases mortality in burn patients with inhalation injuries. We evaluated whether the use of High Frequency Percussive Ventilation (HFPV) in burn patients with inhalation injuries can decrease rates of Ventilator Associated Pneumonia (VAP) compared to Volume Control Ventilation (VCV). METHODS: Data were gathered from PubMed, EMBASE, Web of Science, reference lists, and hand search. For unpublished data we searched and RePORTER...
September 2016: Burns: Journal of the International Society for Burn Injuries
Nikhil G Thaker, Laurie Sturdevant, Anuja Jhingran, Prajnan Das, Marc E Delclos, Gary B Gunn, Mary Frances McAleer, Welela Tereffe, Seungtaek L Choi, Steven J Frank, William J Simeone, Wendi Martinez, Stephen M Hahn, Robin Famiglietti, Deborah A Kuban
PURPOSE: Academic centers increasingly find a need to define a comprehensive peer-review program that can translate high-quality radiation therapy (RT) to community network sites. In this study, we describe the initial results of a quarterly quality audit program that aims to improve RT peer-review and provider educational processes across community sites. MATERIALS AND METHODS: An electronic tool was used by community-based certified member (CM) sites to enter clinical treatment information about patients undergoing peer review...
April 2016: Journal of Oncology Practice
C Brendan Clark, Cosmas M Zyambo, Ye Li, Karen L Cropsey
BACKGROUND: Studies comparing self-report substance use data to biochemical verification generally demonstrate high rates of concordance. We argue that these rates are due to the relatively high true negative rate in the general population, and high degree of honestly in treatment seeking individuals. We hypothesized that high risk individuals not seeking treatment would demonstrate low concordance and a high false negative rate of self-reported substance use. METHODS: A sample of 500 individuals from a smoking cessation clinical trial was assessed over 1 year...
July 2016: Addictive Behaviors
Christine M Khosropour, Julia C Dombrowski, Fred Swanson, Roxanne P Kerani, David A Katz, Lindley A Barbee, James P Hughes, Lisa E Manhart, Matthew R Golden
BACKGROUND: Serosorting among men who have sex with men (MSM) is common, but recent data to describe trends in serosorting are limited. How serosorting affects population-level trends in HIV and other sexually transmitted infection (STI) risk is largely unknown. METHODS: We collected data as part of routine care from MSM attending a sexually transmitted disease clinic (2002-2013) and a community-based HIV/sexually transmitted disease testing center (2004-2013) in Seattle, WA...
June 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Ibraheem M Malkawi, Esther Han, Christopher S Atalla, Richard A Santucci, Brian O'Neil, Jason B Wynberg
INTRODUCTION: Noncontrast CT is the standard of care to evaluate nephrolithiasis. We evaluated the performance of low-dose CT (LDCT) scan for evaluation of renal colic in the emergency room (ER). MATERIALS AND METHODS: Patients visiting the ER with suspected nephrolithiasis received a standard-dose CT (SDCT) and an LDCT. Two urologists read the LDCTs and later they read SDCTs. Stone information was recorded on a diagram of the renal system. Findings on SDCTs and LDCTs were correlated through side-by-side comparison of the diagrams...
May 2016: Journal of Endourology
Mohamad-Ali Trad, Andreas Baisch
OBJECTIVE: Current management of hospitalised patients with community-acquired pneumonia (CAP) in an Australian regional hospital in accordance with the recommended guidelines is unknown. The prescription rate of inappropriate antibiotic therapy was measured and analysed. DESIGN: A retrospective audit, December 2012 to November 2013. SETTING: Regional Australian hospital in North East Victoria. INTERVENTIONS: Interventions were the average of inpatient and intensive care unit length of stay, time to first antibiotic and to first chest x-ray, days of intravenous antibiotics, and extra intravenous therapy; proportion of intensive care unit admissions, average time to first antibiotic administration, patients with failed outpatient management of CAP, initial microbiological investigations, positive investigations, predominant microbiology, antibiotic choice, and concordance with guidelines; proportion of justifiable deviation from guidelines, ratio of patients switched to oral therapy appropriately, complications during therapy, clinical failure, inpatient mortality, mortality at 30 days, mortality at 6 months, and readmission with CAP in 30 days and in 3 months...
December 21, 2015: Australian Journal of Rural Health
Gabriela Egaña-Ugrinovic, Anna Goncé, Laura García, Maria-Angeles Marcos, Marta López, Alfons Nadal, Francesc Figueras
OBJECTIVE: The purpose of this study was to describe the fetal/neonatal cytomegalovirus (CMV) status according to chorionicity and outcome in twin pregnancies diagnosed with CMV. METHODS: An opportunistic diagnosis of CMV infection was performed in a tertiary referral center. All cases diagnosed in twin pregnancies (2006-2011) were included. Prenatal diagnosis was performed by CMV-DNA in the amniotic fluid (AF) of both fetuses only on the evidence of sonographic findings in either one or both twins...
November 2016: Journal of Maternal-fetal & Neonatal Medicine
Jesús Villar-Del-Moral, João Capela-Costa, Antonio Jiménez-García, Antonio Sitges-Serra, Daniel Casanova-Rituerto, José Rocha, Juan Manuel Martos-Martínez, Aitor de la Quintana-Basarrate, Jorge Rosa-Santos, Xavier Guirao-Garriga, José Miguel Bravo-de-Lifante, Óscar Vidal-Pérez, Antonio Moral-Duarte, José Polónia
PURPOSE: Knowledge about compliance with recommendations derived from the positional statement of the European Society of Endocrine Surgeons on modern techniques in primary hyperparathyroidism surgery and the Third International Workshop on management of asymptomatic primary hyperparathyroidism is scarce. Our purpose was to check it on a bi-national basis and determine whether management differences may have impact on surgical outcomes. METHODS: An online survey including questions about indications, preoperative workup, surgical approach, intraoperative adjuncts, and outcomes was sent to institutions affiliated to the endocrine surgery divisions of the National Surgical Societies from Spain and Portugal...
November 2016: Langenbeck's Archives of Surgery
H E Li, Xuefei Wang, Zhaoqing Tang, Fenglin Liu, Weidong Chen, Yong Fang, Cong Wang, Kuntang Shen, Jing Qin, Zhenbin Shen, Yihong Sun, Xinyu Qin
Fatty acid synthase (FAS) and human epidermal growth factor receptor 2 (HER2) are overexpressed in gastric cancer (GC), and certain interactions have been found between FAS and HER2. A total of 94 patients were enrolled in the present study, each of whom underwent a D2 radical surgery in Zhongshan Hospital affiliated with Fudan University (Shanghai, China) between 2000 and 2005. The expression of FAS and HER2 was assessed by immunohistochemistry analysis of tissue microarrays generated from GC and non-tumor tissues...
October 2015: Oncology Letters
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