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https://www.readbyqxmd.com/read/29808462/improvisation-versus-guideline-concordance-in-surgical-antibiotic-prophylaxis-a-qualitative-study
#1
Jennifer Broom, Alex Broom, Emma Kirby, Jeffrey J Post
PURPOSE: Surgical antibiotic prophylaxis (SAP) is a common area of antimicrobial misuse. The aim of this study was to explore the social dynamics that influence the use of SAP. METHODS: 20 surgeons and anaesthetists from a tertiary referral hospital in Australia participated in semi-structured interviews focusing on experiences and perspectives on SAP prescribing. Interview data were analysed using the framework approach. RESULTS: Systematic analysis of the participants' account of the social factors influencing SAP revealed four themes...
May 28, 2018: Infection
https://www.readbyqxmd.com/read/29743018/exploring-current-and-potential-roles-of-australian-community-pharmacists-in-gout-management-a-qualitative-study
#2
Allyce B Counsell, Amy D Nguyen, Melissa T Baysari, Diluk R W Kannangara, Andrew J McLachlan, Richard O Day
BACKGROUND: Gout is an increasingly prevalent form of inflammatory arthritis. Although effective treatments for gout exist, current management is suboptimal due to low medication adherence rates and treatments that are non-concordant with guidelines. Medications are the mainstay and most effective form of gout management. Thus, there is potential for community pharmacists to play an important primary health care role in gout management, however their current role and their potential to improve management of gout treatment is currently unclear...
May 9, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29579012/the-influence-of-concordant-complex-posture-and-loading-rate-on-motion-segment-failure-a-mechanical-and-microstructural-investigation
#3
Meredith L Schollum, Kelly R Wade, Zhi Shan, Peter A Robertson, Ashvin Thambyah, Neil D Broom
STUDY DESIGN: Microstructural investigation of compression induced herniation of a lumbar disc held in a concordant complex posture. OBJECTIVE: To explore the significance of loading rate in a highly asymmetric concordant posture, comparing the mechanisms of failure to an earlier study using a non-concordant complex posture. SUMMARY OF BACKGROUND DATA: A recent study with a non-concordant complex posture (turning in the opposite direction to that which the load is applied) demonstrated the vulnerability of the disc to loading that is borne by one set of oblique-counter oblique fibre sets in the alternating lamellae of the annulus, and aggravated by an elevated loading rate...
March 23, 2018: Spine
https://www.readbyqxmd.com/read/29477653/the-diagnosis-of-chronic-endometritis-in-infertile-asymptomatic-women-a-comparative-study-of-histology-microbial-cultures-hysteroscopy-and-molecular-microbiology
#4
Inmaculada Moreno, Ettore Cicinelli, Iolanda Garcia-Grau, Marta Gonzalez-Monfort, Davide Bau, Felipe Vilella, Dominique De Ziegler, Leonardo Resta, Diana Valbuena, Carlos Simon
BACKGROUND: Chronic endometritis is a persistent inflammation of the endometrial mucosa caused by bacterial pathogens such as Enterobacteriaceae, Enterococcus, Streptococcus, Staphylococcus, Mycoplasma, and Ureaplasma. Although chronic endometritis can be asymptomatic, it is found in up to 40% of infertile patients and is responsible for repeated implantation failure and recurrent miscarriage. Diagnosis of chronic endometritis is based on hysteroscopy of the uterine cavity, endometrial biopsy with plasma cells being identified histologically, while specific treatment is determined based on microbial culture...
February 23, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29433464/the-accuracy-of-parent-reported-height-and-weight-for-6-12-year-old-u-s-children
#5
Davene R Wright, Karen Glanz, Trina Colburn, Shannon M Robson, Brian E Saelens
BACKGROUND: Previous studies have examined correlations between BMI calculated using parent-reported and directly-measured child height and weight. The objective of this study was to validate correction factors for parent-reported child measurements. METHODS: Concordance between parent-reported and investigator measured child height, weight, and BMI (kg/m2 ) among participants in the Neighborhood Impact on Kids Study (n = 616) was examined using the Lin coefficient, where a value of ±1...
February 12, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29367579/vertebrate-left-right-asymmetry-what-can-nodal-cascade-gene-expression-patterns-tell-us
#6
REVIEW
Axel Schweickert, Tim Ott, Sabrina Kurz, Melanie Tingler, Markus Maerker, Franziska Fuhl, Martin Blum
Laterality of inner organs is a wide-spread characteristic of vertebrates and beyond. It is ultimately controlled by the left-asymmetric activation of the Nodal signaling cascade in the lateral plate mesoderm of the neurula stage embryo, which results from a cilia-driven leftward flow of extracellular fluids at the left-right organizer. This scenario is widely accepted for laterality determination in wildtype specimens. Deviations from this norm come in different flavors. At the level of organ morphogenesis, laterality may be inverted (situs inversus) or non-concordant with respect to the main body axis (situs ambiguus or heterotaxia)...
December 29, 2017: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29363225/uptake-of-adjuvant-breast-cancer-treatments-recommended-by-multi-disciplinary-meetings
#7
Melinda Pattanasri, Kenneth Elder, Carolyn Nickson, Samuel Cooke, Dorothy Machalek, Allison Rose, Arlene Mou, John P Collins, Allan Park, Richard De Boer, Claire Phillips, Vicki Pridmore, Helen Farrugia, G Bruce Mann
BACKGROUND: Adjuvant therapy for breast cancer is routinely discussed and recommended in multi-disciplinary meetings (MDMs). Current literature explores how treatments received by patients differ from national guidelines; however, it does not explore whether treatment is concordant with MDMs. This study provides an Australian perspective on the uptake of MDM recommendations and reasons for non-concordance. METHODS: A retrospective cohort study of patients with breast cancer presented at The Royal Melbourne Hospital MDM in 2010 and 2014 to investigate the concordance between MDM recommendations and treatment received...
January 23, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29192946/-aripiprazole-induced-hyperhidrosis-two-case-reports
#8
Adarsh Vohra
Many drugs including anti-depressants and anti-psychotics are known to cause excessive sweating (hyperhidrosis). Hyperhidrosis may be caused by drugs acting at the hypothalamus, spinal thermoregulatory centres, and sympathetic ganglia or at the eccrine-neuroeffector junction. Hyperhidrosis can be distressing and embarrassing symptom, which if not addressed properly, may lead to non-concordance to medication. Two female patients are reported here who developed hyperhidrosis with aripiprazole. Both the patients stopped experiencing hyperhidrosis after their aripiprazole was discontinued...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/29190125/mitotic-instability-in-triploid-and-tetraploid-one-year-old-eastern-oyster-crassostrea-virginica-assessed-by-cytogenetic-and-flow-cytometry-techniques
#9
Joana Teixeira de Sousa, Standish K Allen, Brittany M Wolfe, Jessica Moss Small
For commercial oyster aquaculture, triploidy has significant advantages. To produce triploids, the principal technology uses diploid × tetraploid crosses. The development of tetraploid brood stock for this purpose has been successful, but as more is understood about tetraploids, it seems clear that chromosome instability is a principal feature in oysters. This paper is a continuation of work to investigate chromosome instability in polyploid Crassostrea virginica. We established families between tetraploids-apparently stable (non-mosaic) and unstable (mosaic)-and normal reference diploids, creating triploid groups, as well as tetraploids between mosaic and non-mosaic tetraploids...
February 2018: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29141740/a-lateral-flow-rapid-test-for-human-toxocariasis-developed-using-three-toxocara-canis-recombinant-antigens
#10
Muhammad Hafiznur Yunus, Siti Naqiuyah Tan Farrizam, Izzati Zahidah Abdul Karim, Rahmah Noordin
Laboratory diagnosis of toxocariasis is still a challenge especially in developing endemic countries with polyparasitism. In this study, three Toxocara canis recombinant antigens, rTES-26, rTES-30, and rTES-120, were expressed and used to prepare lateral flow immunoglobulin G4 (IgG4) dipsticks. The concordance of the results of the rapid test (comprising three dipsticks) with a commercial IgG-enzyme-linked immunosorbent assay (ELISA) (Cypress Diagnostics, Belgium) was compared against the concordance of two other commercial IgG-ELISA kits (Bordier, Switzerland and NovaTec, Germany) with the Cypress kit...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29122927/antipsychotic-induced-hyperprolactinaemia-case-studies-and-review
#11
REVIEW
Shweta Mittal, Suveera Prasad, Adwaita Ghosh
Antipsychotics are a known cause of hyperprolactinaemia and can be associated with significant health issues in short term and long term. The effects vary with gender and age of the individual and can contribute towards non-concordance and hence relapse in mental health of our patients. Clinicians need to educate the patients about this significant side effect of not only antipsychotic medications but other medications causing hyperprolactinaemia commonly prescribed in primary care.
April 2018: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29024067/evaluation-of-multiplex-real-time-pcr-for-identifying-dermatophytes-in-clinical-samples-a-multicentre-study
#12
Shany Sherman, Maya Goshen, Orit Treigerman, Keren Ben-Zion, Marie-Jeanne Carp, Noam Maisler, Inbal Binsky Ehrenreich, Aviva Kimchi, Sara Lifshitz, Gill Smollan, Batya Davidovici, Michael David, Emmilia Hodak, Rina Segal
The gold-standard method for dermatophyte identification involves direct microscopy and culture, which have inherent shortcomings. Only few molecular methods have been standardised for routine clinical work. This study aimed to develop and test a platform for identifying the most common dermatophytes in Israel using multiplex real-time polymerase chain reaction (RT-PCR). Specific primers were designed for the multiplex system (LightCycler 480) according to known cultures and validated by reference isolates...
February 2018: Mycoses
https://www.readbyqxmd.com/read/28878936/primary-care-physicians-utilization-of-type-2-diabetes-screening-guidelines-and-referrals-to-behavioral-interventions-a-survey-linked-retrospective-study
#13
Sandhya Mehta, Michelle Mocarski, Tami Wisniewski, Karin Gillespie, K M Venkat Narayan, Kathleen Lang
OBJECTIVE: To assess primary care physicians' (PCPs) knowledge of type 2 diabetes screening guidelines (American Diabetes Association (ADA) and 2008 US Preventive Services Task Force (USPSTF)), the alignment between their self-reported adherence and actual practice, and how often PCPs recommended diabetes prevention and self-management education programs (DPP/DSME). RESEARCH DESIGN AND METHODS: An online survey of PCPs to understand knowledge and adherence toward use of USPSTF/ADA guidelines and recommendation of DPP/DSME...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28729096/can-the-presence-of-a-surrounding-endometrium-differentiate-eccentrically-located-intrauterine-pregnancy-from-interstitial-ectopic-pregnancy
#14
Allison Grant, Ally Murji, Mostafa Atri
OBJECTIVES: Differentiation of an eccentric intrauterine pregnancy (IUP) from an interstitial ectopic pregnancy (EP) is challenging. No sign for differentiation is reported. The purpose of this study was to determine whether the presence of surrounding endometrium (SE) can distinguish eccentric IUP from interstitial EP. METHODS: This study was approved by the institutional ethics board; consent acquisition was waived. Cases were identified using ultrasound (US) reports that included the words "interstitial," "cornual," and "angular...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28547563/poor-adherence-to-national-clinical-management-guidelines-a-population-based-cross-sectional-study-of-the-surgical-management-of-melanoma-in-new-south-wales-australia
#15
Alexander H R Varey, Christine M Madronio, Anne E Cust, Chris Goumas, Graham J Mann, Bruce K Armstrong, Richard A Scolyer, Austin M Curtin, John F Thompson
BACKGROUND: Standardization of the clinical management of melanoma through the formulation of national guidelines, based on interpretation of the existing evidence and consensus expert opinion, seeks to improve quality of care; however, adherence to national guidelines has not been well studied. METHODS: A population-based, cross-sectional study of the clinical management of all patients with newly notified primary melanomas in the state of New South Wales, Australia, during 2006/2007 was conducted using cancer registry identification and questionnaires completed by treating physicians...
August 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28433727/superficial-swab-versus-deep-tissue-biopsy-for-the-microbiological-diagnosis-of-local-infection-in-advanced-stage-pressure-ulcers-of-spinal-cord-injured-patients-a-prospective-study
#16
COMPARATIVE STUDY
S Tedeschi, L Negosanti, R Sgarzani, F Trapani, S Pignanelli, M Battilana, R Capirossi, D Brillanti Ventura, M Giannella, M Bartoletti, F Tumietto, F Cristini, P Viale
OBJECTIVE: To assess the predictive value of superficial ulcer swab culture to make a microbiological diagnosis of deep wound infections in spinal cord injury (SCI) patients with advanced-stage pressure ulcers. METHODS: From July 2011 to February 2014, we performed a prospective, single-centre study on adult SCI patients undergoing scheduled surgical debridement and reconstruction for advanced-stage pressure ulcers, at Montecatone Rehabilitation Institute, a 150-bed hospital dedicated to SCI care...
December 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28405501/pdl1-expression-is-a-poor-prognosis-factor-in-soft-tissue-sarcomas
#17
François Bertucci, Pascal Finetti, Delphine Perrot, Agnès Leroux, Françoise Collin, Axel Le Cesne, Jean-Michel Coindre, Jean-Yves Blay, Daniel Birnbaum, Emilie Mamessier
Soft-tissue sarcomas (STS) are a group of rare, heterogeneous, and aggressive tumors, with high metastatic risk and relatively few efficient systemic therapies. In the quest for new treatments, the immune system represents an attractive therapeutic target. Recently, PD1/PDL1 inhibitors showed very promising results in patients with solid tumors. PDL1 expression has been rarely studied in STS, in small series only, by using immunohistochemistry (IHC), and with non-concordant prognostic implications. Here, we have analyzed PDL1 mRNA expression in 758 clinical STS samples retrospectively profiled using DNA microarrays and RNAseq, and searched for correlations with clinicopathological variables including metastasis-free survival (MFS) after surgery...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28286183/ordering-the-mob-insights-into-replicon-and-mob-typing-schemes-from-analysis-of-a-curated-dataset-of-publicly-available-plasmids
#18
Alex Orlek, Hang Phan, Anna E Sheppard, Michel Doumith, Matthew Ellington, Tim Peto, Derrick Crook, A Sarah Walker, Neil Woodford, Muna F Anjum, Nicole Stoesser
Plasmid typing can provide insights into the epidemiology and transmission of plasmid-mediated antibiotic resistance. The principal plasmid typing schemes are replicon typing and MOB typing, which utilize variation in replication loci and relaxase proteins respectively. Previous studies investigating the proportion of plasmids assigned a type by these schemes ('typeability') have yielded conflicting results; moreover, thousands of plasmid sequences have been added to NCBI in recent years, without consistent annotation to indicate which sequences represent complete plasmids...
May 2017: Plasmid
https://www.readbyqxmd.com/read/28279887/evaluation-of-percutaneous-vacuum-assisted-intact-specimen-breast-biopsy-device-for-ultrasound-visualized-breast-lesions-upstage-rates-and-long-term-follow-up-for-high-risk-lesions-and-dcis
#19
Cathy L Graham
OBJECTIVE: Percutaneous core biopsy of ultrasound visualized breast lesions is standard for diagnosis. Large gauge vacuum-assisted core needles have improved accuracy; but a significant underestimation of malignancy remains. The IntactR device was assessed for upstaging and subsequent malignancy at the biopsy site. METHODS: 469 consecutive ultrasound visualized breast lesions, < 2.0 cm in size, BIRADS 4 or 5, biopsied with IntactR Breast Lesion Excision System, between July 2007 and August 2014, were reviewed...
June 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28278000/successful-outpatient-management-of-lymphoedema-and-lymphorrhoea-with-wrap-around-compression-a-case-study
#20
L Patullo, S Rajagopalan
Referral to specialist centres for treatment of lymphoedema can often have long waiting times. Management of a patient with massive lymphoedema and lymphorrhoea was provided in a vascular outpatient setting. A new form of compression using a wraparound system was used for the management (Juxta-Fit, Medi UK). Despite having previously been non-concordant with treatment options, the patient was independent with product use. Lymphorrhoea ceased and there was a marked decrease in girth size. The patient's quality of life improved and maintenance treatment was provided...
March 2, 2017: Journal of Wound Care
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