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https://www.readbyqxmd.com/read/28938413/prenatal-diagnosis-of-resistance-to-thyroid-hormone-and-its-clinical-implications
#1
Theodora Pappa, João Anselmo, Sunnee Mamanasiri, Alexandra M Dumitrescu, Roy E Weiss, Samuel Refetoff
Context: Resistance to thyroid hormone beta (RTHβ) is an autosomal dominant disorder characterized by reduced sensitivity of target tissues to thyroid hormones (TH). Individuals with RTHβ have high TH levels usually due to mutations in the TH receptor beta (THRB) gene. The management of RTHβ during pregnancy is challenging as wild-type (WT) fetuses born to RTHβ mothers have low birth weight and suppressed postnatal TSH, due to intrauterine exposure to excess TH. Objective: To determine birth weight and postnatal TSH of WT fetuses carried by mothers with RTHβ whose fT4 levels were maintained below 20% the upper limit of normal (ULN)...
August 4, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28934915/-significant-intraventricular-hemorrhage-is-more-likely-in-very-preterm-infants-born-by-vaginal-delivery-a-multi-centre-retrospective-cohort-study
#2
Islam Gamaleldin, David Harding, Dimitrios Siassakos, Tim Draycott, David Odd
OBJECTIVES: To determine the association between mode of delivery (vaginal delivery [VD] versus cesarean section [CS]) and the rate of significant intraventricular hemorrhage (sIVH) in preterm infants. METHODS: A multicenter retrospective cohort study, based on data collected from the Vermont Oxford Network database. Infants born between 23 and 31(+6) weeks of gestational age between 2001 and 2014 were identified. Exposure was the mode of birth (VD versus CS). Primary outcome was development of sIVH...
September 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28926210/clinical-relevance-of-retinal-structure-in-children-with-laser-treated-retinopathy-of-prematurity-versus-controls-using-optical-coherence-tomography
#3
Florina Stoica, Adela Chirita-Emandi, Nicoleta Andreescu, Alina Stanciu, Cristian G Zimbru, Maria Puiu
PURPOSE: We aimed to assess the macular anatomy using spectral domain optical coherence tomography (SD-OCT), in children born preterm who had laser-treated retinopathy of prematurity (ROP), and to investigate the relationship between structural changes in macula and visual function. METHODS: Thirty-seven 3-8 years old children were included in the study in two groups: 20 children born preterm [(<34 weeks of gestation, birthweight (BW) <2000 g)] who had laser-treated ROP in the Neonatology Department, Municipal Clinical Emergency Hospital of Timisoara, Romania; and 17 controls (children born at term, without eye disease, matched for age and gender)...
September 19, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28915232/effects-of-early-nutrition-and-growth-on-brain-volumes-white-matter-microstructure-and-neurodevelopmental-outcome-in-preterm-newborns
#4
Caterina Coviello, Kristin Keunen, Karina J Kersbergen, Floris Groenendaal, Alexander Leemans, Barbara Peels, Ivana Isgum, Max A Viergever, Linda S de Vries, Giuseppe Buonocore, Virgilio P Carnielli, Manon J N L Benders
BACKGROUND: This study aimed to investigate the effect of nutrition and growth during the first 4 weeks after birth on cerebral volumes and white matter maturation at term equivalent age(TEA) and on neurodevelopmental outcome at 2 years corrected age(CA), in preterm infants. METHODS: 131 infants born at a gestational age(GA)<31weeks with MRI at TEA were studied. Cortical gray matter volumes(CGM), basal ganglia and thalami(BGT) volumes, cerebellar volumes and total brain volume(TBV) were computed...
September 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28915231/postnatal-polyunsaturated-fatty-acids-associated-with-larger-preterm-brain-tissue-volumes-and-better-outcomes
#5
Daphne Kamino, Colin Studholme, Mengyuan Liu, Vann Chau, Steven P Miller, Anne Synnes, Elizabeth E Rogers, A James Barkovich, Donna M Ferriero, Rollin Brant, Emily W Y Tam
BACKGROUND: Human studies investigating the link between postnatal polyunsaturated fatty acids and preterm brain growth are limited, despite emerging evidence of potential effects on outcomes. METHODS: Sixty preterm neonates <32 weeks gestational age with MRI scanning at near-birth and near-term age were assessed for brain tissue volumes including cortical grey matter, white matter, deep grey matter, cerebellum, brainstem and ventricular cerebrospinal fluid. Red blood cell fatty acid content was evaluated within 1 week of each MRI scan...
September 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28904809/magnetic-resonance-imaging-performance-for-diagnosis-of-ovarian-torsion-in-pregnant-women-with-stimulated-ovaries
#6
Elizabeth Asch, Jesse Wei, Koenraad J Mortele, Kathryn Humm, Kim Thornton, Deborah Levine
BACKGROUND: To determine if asymmetric ovarian edema on non-contrast MRI can be used to distinguish torsed from non-torsed stimulated ovaries in pregnant women. METHODS: In this retrospective study, our radiology database was searched for women who were pregnant and who had undergone ovarian stimulation and underwent MRI abdomen/pelvis from 1/2000-12/2012. At our institution, ultrasound is typically performed as a first line study for pregnant women with pelvic pain, with MR for those patients with indeterminate findings...
2017: Fertility Research and Practice
https://www.readbyqxmd.com/read/28877554/the-role-of-sociodemographic-factors-in-maternal-psychological-distress-and-mother-preterm-infant-interactions
#7
Kaboni W Gondwe, Rosemary White-Traut, Debra Brandon, Wei Pan, Diane Holditch-Davis
Preterm birth has been associated with greater psychological distress and less positive mother infant interactions than were experienced by mothers of full-term infants. Maternal and infant sociodemographic factors have also shown a strong association with psychological distress and the mother-infant relationship. However, findings on their effects over time are limited. In this longitudinal analysis, we explored the relationship of maternal and infant sociodemographic variables (maternal age, maternal education, marital status, being on social assistance, maternal race, infant birth weight, and infant gender) to maternal psychological distress (depressive, posttraumatic stress, anxiety, parenting stress symptoms, and maternal worry about child's health) through 12 months corrected age for prematurity, and on the home environment, and mother-infant interactions through 6 months corrected age for prematurity...
September 6, 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/28871602/elective-transfers-of-preterm-neonates-to-regional-centres-on-non-invasive-respiratory-support-is-cost-effective-and-increases-tertiary-care-bed-capacity
#8
Hussein Zein, Kamran Yusuf, Renee Paul, Derek Kowal, Sumesh Thomas
AIM: Managing capacity at regional facilities caring for sick neonates is increasingly challenging. This study estimated the clinical and economic impact of the elective transfer of stable infants requiring nasal continuous positive airway pressure (NCPAP) from level three to level two neonatal intensive care units (NICUs) within an established clinical network of five NICUs. METHODS: We retrospectively analysed the records of 99 stable infants transferred on NCPAP between two level three NICUs and three level two NICUs in Calgary, Canada, between June 2014 and May 2016...
September 4, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28866004/neurodevelopmental-outcomes-of-infants-with-very-low-birth-weights-are-associated-with-the-severity-of-their-extra-uterine-growth-retardation
#9
Han-Chun Chien, Chao-Huei Chen, Teh-Ming Wang, Ya-Chi Hsu, Ming-Chih Lin
BACKGROUND: For infants with very low birth weights (VLBW), their neurodevelopmental outcomes are thought to be associated with extra-uterine growth retardation (EUGR). In this study, based on a single institute, we analyzed the association between different levels or severity of EUGR of VLBW infants and their neurodevelopmental outcomes later at a corrected age of 24 months. METHODS: This is a hospital-based retrospective cohort study. The severity of EUGR was classified into three categories according to the z-score of discharge weight: z < -2...
August 11, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28856723/sources-of-influence-on-pregnant-women-s-preferred-mode-of-delivery-in-buenos-aires-argentina
#10
Melissa Amyx, Luz Gibbons, Xu Xiong, Agustina Mazzoni, Fernando Althabe, Pierre Buekens, José M Belizán
BACKGROUND: Understanding influences on women's preferred delivery mode is vital for planning interventions to reduce cesarean rates and for ensuring that women receive correct information. Our objectives were to: determine if sources of information influencing a pregnant woman's preferred delivery mode and knowledge of cesarean indications differ by sociodemographic characteristics; to conduct a factor analysis of items related to information sources influencing this preference; and to determine if knowledge differs by information sources influencing this preference or their underlying latent constructs...
August 29, 2017: Birth
https://www.readbyqxmd.com/read/28854518/intestinal-perforation-in-the-premature-infant
#11
K Ongbhavit, M A Underwood
OBJECTIVE: To compare demographic data, prenatal and postnatal characteristics, laboratory data, and outcomes in a cohort of premature infants with spontaneous ileal perforation (SIP), surgical necrotizing enterocolitis (sNEC) and matched controls. METHODS: A retrospective case-control study of infants with intestinal perforation with a birth weight (BW) less than 2,000 grams and gestational age (GA) less than 34 weeks and infants without perforation matched for BW (±150 grams) and GA (±1week)...
August 23, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28852074/mapping-white-matter-microstructure-in-the-one-month-human-brain
#12
D C Dean, E M Planalp, W Wooten, N Adluru, S R Kecskemeti, C Frye, C K Schmidt, N L Schmidt, M A Styner, H H Goldsmith, R J Davidson, A L Alexander
White matter microstructure, essential for efficient and coordinated transmission of neural communications, undergoes pronounced development during the first years of life, while deviations to this neurodevelopmental trajectory likely result in alterations of brain connectivity relevant to behavior. Hence, systematic evaluation of white matter microstructure in the normative brain is critical for a neuroscientific approach to both typical and atypical early behavioral development. However, few studies have examined the infant brain in detail, particularly in infants under 3 months of age...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818852/accuracy-of-11-formulae-to-guide-umbilical-arterial-catheter-tip-placement-in-newborn-infants
#13
Wei Ling Lean, Jennifer A Dawson, Peter G Davis, Christiane Theda, Marta Thio
BACKGROUND: Umbilical arterial catheter (UAC) insertion is a common procedure in the neonatal intensive care unit (NICU). Correct placement of the tip of the UAC at first attempt minimises handling of the infant and reduces the risk of infection and complications. We aimed to determine the accuracy of 11 published formulae to guide UAC placement. METHODS: This was a one-year prospective observational study in a tertiary NICU. Clinicians used their preferred formula for UAC insertion, with X-rays performed immediately post-procedure to check the tip position...
August 17, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28814566/neurodevelopmental-outcome-at-2-years-for-preterm-children-born-at-22-to-34-weeks-gestation-in-france-in-2011-epipage-2-cohort-study
#14
Véronique Pierrat, Laetitia Marchand-Martin, Catherine Arnaud, Monique Kaminski, Matthieu Resche-Rigon, Cécile Lebeaux, Florence Bodeau-Livinec, Andrei S Morgan, François Goffinet, Stéphane Marret, Pierre-Yves Ancel
Objectives To describe neurodevelopmental outcomes at 2 years corrected age for children born alive at 22-26, 27-31, and 32-34 weeks' gestation in 2011, and to evaluate changes since 1997.Design Population based cohort studies, EPIPAGE and EPIPAGE-2.Setting France.Participants 5567 neonates born alive in 2011 at 22-34 completed weeks' gestation, with 4199 survivors at 2 years corrected age included in follow-up. Comparison of outcomes reported for 3334 (1997) and 2418 (2011) neonates born alive in the nine regions participating in both studies...
August 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28797126/development-of-salivary-cortisol-circadian-rhythm-in-preterm-infants
#15
Katrin Ivars, Nina Nelson, Annette Theodorsson, Elvar Theodorsson, Jakob O Ström, Evalotte Mörelius
OBJECTIVES: To investigate at what age preterm infants develop a salivary cortisol circadian rhythm and identify whether it is dependent on gestational age and/or postnatal age. To evaluate whether salivary cortisol circadian rhythm development is related to behavioral regularity. To elucidate salivary cortisol levels in preterm infants during the first year of life. METHODS: This prospective, longitudinal study included 51 preterm infants. 130 healthy full-term infants served as controls...
2017: PloS One
https://www.readbyqxmd.com/read/28795424/going-with-the-flow-an-aid-in-detecting-and-differentiating-bronchopulmonary-sequestrations-and-hybrid-lesions
#16
Edward R Oliver, Suzanne E DeBari, Mariann M Giannone, Jennifer E Pogoriler, Ann M Johnson, Steven C Horii, Juliana S Gebb, Lori J Howell, N Scott Adzick, Beverly G Coleman
OBJECTIVES: To assess the ability of prenatal ultrasound (US) in identifying systemic feeding arteries in bronchopulmonary sequestrations and hybrid lesions and report the ability of US in classifying bronchopulmonary sequestrations as intralobar or extralobar. METHODS: Institutional Review Board-approved radiology and clinical database searches from 2008 to 2015 were performed for prenatal lung lesions with final diagnoses of bronchopulmonary sequestrations or hybrid lesions...
August 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28794133/presence-and-pattern-of-scarring-in-children-born-very-preterm
#17
Anna C Tottman, Jane M Alsweiler, Frank H Bloomfield, Jane E Harding
The long-term scarring burden of preterm infants undergoing modern neonatal intensive care is not known. This observational cohort study aimed to document the presence and pattern of scarring in children born <30 weeks' gestation or <1500 g birth weight and cared for at the National Women's Health neonatal intensive care unit, Auckland, New Zealand. Children were examined at 7 years' corrected age and the presence, size, number and distribution of scars documented. Scarring was seen in 90% of 129 children assessed, with 81% having multiple scars, 60% having large scars (85% of whom had no history of major neonatal surgery) and 75% having more than one body area scarred...
August 9, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28774688/prenatal-exposure-to-drinking-water-chlorination-by-products-cytochrome-p450-gene-polymorphisms-and-small-for-gestational-age-neonates
#18
Samuella G Bonou, Patrick Levallois, Yves Giguère, Manuel Rodriguez, Alexandre Bureau
Genetic susceptibility may modulate chlorination by-products (CBPs) effects on fetal growth, especially genes coding for the cytochrome P450 involved in the metabolism of CBPs and steroidogenesis. In a case-control study of 1432 mother-child pairs, we assessed the association between maternal and child single nucleotide polymorphisms (SNPs) within CYP1A2, CYP2A6, CYP2D6 and CYP17A1 genes and small-for-gestational-age neonates (SGA<10th percentile) as well as interaction between these SNPs and maternal exposure to trihalomethanes or haloacetic acids (HAAs) during the third trimester of pregnancy...
July 31, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28766127/metabolic-profiling-of-gestational-diabetes-in-obese-women-during-pregnancy
#19
Sara L White, Dharmintra Pasupathy, Naveed Sattar, Scott M Nelson, Debbie A Lawlor, Annette L Briley, Paul T Seed, Paul Welsh, Lucilla Poston
AIMS/HYPOTHESIS: Antenatal obesity and associated gestational diabetes (GDM) are increasing worldwide. While pre-existing insulin resistance is implicated in GDM in obese women, the responsible metabolic pathways remain poorly described. Our aim was to compare metabolic profiles in blood of obese pregnant women with and without GDM 10 weeks prior to and at the time of diagnosis by OGTT. METHODS: We investigated 646 women, of whom 198 developed GDM, in this prospective cohort study, a secondary analysis of UK Pregnancies Better Eating and Activity Trial (UPBEAT), a multicentre randomised controlled trial of a complex lifestyle intervention in obese pregnant women...
August 1, 2017: Diabetologia
https://www.readbyqxmd.com/read/28754278/-effects-of-deformational-plagiocephaly-during-the-first-12%C3%A2-months-on-the-psychomotor-development-of-prematurely-born-infants
#20
M Fabre-Grenet, P Garcia-Méric, V Bernard-Niel, V Guagliardo, S Cortaredona, M Aymeric-Ponsonnet
AIMS: The link between deformational plagiocephaly and psychomotor development is a recurrent question in medical publications. Main publications concentrate on term infants, but there is a lack of data on the impact of deformational plagiocephaly on the long-term neurodevelopment of premature infants. We attempted to establish a possible relation between deformational plagiocephaly during the 1st year of life and the psychomotor score at 4 years in prematurely born infants. Other risk factors potentially impacting the psychomotor score were also studied...
July 25, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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