Chao Yu, Jing Zhao, Feng Cheng, Jiangjie Chen, Jinyang Chen, Haibin Xu, Kesi Shi, Kaishun Xia, Siwen Ding, Kanbin Wang, Ronghao Wang, Yazhou Chen, Yi Li, Hao Li, Qixin Chen, Xiaohua Yu, Fangwei Shao, Chengzhen Liang, Fangcai Li
Circular RNAs (circRNAs) play a critical regulatory role in degenerative diseases; however, their functions and therapeutic applications in intervertebral disc degeneration (IVDD) have not been explored. Here, we identified that a novel circATXN1 highly accumulates in aging nucleus pulposus cells (NPCs) accountable for IVDD. CircATXN1 accelerates cellular senescence, disrupts extracellular matrix organization, and inhibits mitochondrial respiration. Mechanistically, circATXN1, regulated by heterogeneous nuclear ribonucleoprotein A2B1-mediated splicing circularization, promotes progerin translocation from the cell nucleus to the cytoplasm and inhibits the expression of insulin-like growth factor 1 receptor (IGF-1R)...
2024: Research: a science partner journal