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correction for prematurity

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https://www.readbyqxmd.com/read/28087723/prophylactic-propranolol-for-prevention-of-rop-and-visual-outcome-at-1%C3%A2-year-prerop-trial
#1
Kishore Pratap Sanghvi, Nandkishor S Kabra, Phalguni Padhi, Umesh Singh, Swarup Kumar Dash, Bhupendra S Avasthi
OBJECTIVE: To evaluate the role of prophylactic propranolol in the prevention of retinopathy of prematurity (ROP) in infants ≤32 weeks of gestational age and their visual outcome at 1 year of corrected gestational age. DESIGN: Randomised double blind placebo controlled trial, parallel group nrolment with allocation ratio of 1:1. SETTINGS: Two level III neonatal intensive care units. PARTICIPANTS: 109 preterm neonates of ≤32 weeks of gestation with postnatal age ≤8 days old...
January 13, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28087423/is-middle-cerebral-artery-doppler-related-to-neonatal-and-2-year-infant-outcome-in-early-fetal-growth-restriction
#2
Tamara Stampalija, Birgit Arabin, Hans Wolf, Caterina M Bilardo, Christoph Lees
BACKGROUND: Reduced fetal middle cerebral artery Doppler impedance is associated with hypoxemia in fetal growth restriction. It remains unclear as to whether this finding could be useful in timing delivery especially in third trimester. In this regard there is a paucity of evidence from prospective studies. OBJECTIVES: The aim of this study was to determine whether there is an association between middle cerebral artery Doppler impedance and its ratio with the umbilical artery in relation to neonatal and 2-year infant outcome in early fetal growth restriction (26(+0)-31(+6) weeks of gestation)...
January 10, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28074825/goldenhar-syndrome-cardiac-anesthesiologist-s-perspective
#3
REVIEW
Minati Choudhury, Poonam Malhotra Kapoor
Goldenhar syndrome or oculo-auriculo-vertebral dysplasia was defined by Goldenhar in 1952 and redefined by Grolin et al. later. As the name denotes, children with this syndrome present with craniofacial and vertebral anomalies which increase the risk of airway compromise. Neonates and infants with this syndrome often have premature internal organs, low birth weight, and airway disorders. For this reason, safe anesthesia in such infants requires a complete knowledge regarding metabolism and side effects of the drugs...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28065590/mechanism-and-evidence-of-nonsense-suppression-therapy-for-genetic-eye-disorders
#4
REVIEW
Rose Richardson, Matthew Smart, Dhani Tracey-White, Andrew Webster, Mariya Moosajee
Between 5 and 70% of genetic disease is caused by in-frame nonsense mutations, which introduce a premature termination codon (PTC) within the disease-causing gene. Consequently, during translation, non-functional or gain-of-function truncated proteins of pathological significance, are formed. Approximately 50% of all inherited retinal disorders have been associated with PTCs, highlighting the importance of novel pharmacological or gene correction therapies in ocular disease. Pharmacological nonsense suppression of PTCs could delineate a therapeutic strategy that treats the mutation in a gene- and disease-independent manner...
January 5, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28058660/hepatobiliary-scintigraphy-may-improve-radioembolization-treatment-planning-in-hcc-patients
#5
Manon N G J A Braat, Hugo W de Jong, Beatrijs A Seinstra, Mike V Scholten, Maurice A A J van den Bosch, Marnix G E H Lam
BACKGROUND: Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pretreatment liver function and its segmental distribution, using hepatobiliary scintigraphy may improve patient selection and treatment planning. A case series will be presented to illustrate the potential of this technique. Hepatocellular carcinoma patients with cirrhosis (Child-Pugh A and B) underwent hepatobiliary scintigraphy pre- and 3 months post-radioembolization as part of a prospective study protocol, which was prematurely terminated because of limited accrual...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28054213/visual-outcome-and-refractive-status-in-first-3%C3%A2-years-of-age-in-preterm-infants-suffered-from-laser-treated-type-1-retinopathy-of-prematurity-rop-a-6-year-retrospective-review-in-a-tertiary-centre-in-hong-kong
#6
Julie Y C Lok, Wilson W K Yip, Abbie S W Luk, Joyce K Y Chin, Henry H W Lau, Alvin L Young
PURPOSE: To report the visual outcome and refractive status in first 3 years of age in preterm infants suffered from laser-treated Type 1 retinopathy of prematurity (ROP): a 6-year review in Hong Kong DESIGN: Retrospective case series METHODOLOGY: Clinical records of all infants suffered from Type 1 ROP who had undergone laser therapy between 2007 and 2012 were retrospectively reviewed. Basic demographic data, serial changes of refractive error, visual acuity, severity of ROP and laser were analyzed...
January 4, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28045768/body-composition-trajectories-from-infancy-to-preschool-in-children-born-premature-versus-full-term
#7
Johannah M Scheurer, Lei Zhang, Heather L Gray, Katherine Weir, Ellen W Demerath, Sara E Ramel
OBJECTIVES: The aim of the study was to longitudinally characterize infancy to preschool body composition trajectories and the association of early fat and fat-free mass gains with preschool age body composition in children born premature versus full-term. METHODS: A cohort of appropriate-for-gestational age preterm (n = 20) and term (n = 51) infants were followed at 3 visits: "neonatal" visit 1 at 2 weeks of age for term and near term corrected age for preterm; "infancy" visit 2 at 3 to 4 months (preterm corrected age); "preschool" visit 3 at 4 years...
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28045727/parental-perception-of-risk-associated-with-their-premature-infant
#8
Laura Fletcher, Tammy Pham, Helen Papaioannou, Regina Spinazzola, Ruth Milanaik
BACKGROUND: Preterm birth has been linked to increased parental stress, depression, and anxiety. Although the rate of neonatal morbidity and mortality decreases with increasing gestational age, recent research has revealed that there is no threshold age for risk or parental concern. PURPOSE: This study examines parental concern about medical and developmental outcomes of their premature infant. METHODS: Parents of 60 premature infants were surveyed in a follow-up clinic regarding their level of concern about 11 morbidities and their child's gestation-adjusted age; these were compared with the infant's inpatient chart...
December 31, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28041598/premature-ovarian-insufficiency-and-perinatal-parameters-a-retrospective-case-control-study
#9
S Sadrzadeh, R C Painter, Y M van Kasteren, D D M Braat, C B Lambalk
OBJECTIVE: The peak number of oocytes is reached during intrauterine development, after which numbers decline until reserves are depleted and a woman enters menopause. In premature ovarian insufficiency (POI), the process of follicle depletion occurs at a young age (generally taken as 40 years); the condition affects about 1% of women. In this study, we investigate whether women with POI had experienced a different perinatal milieu, as reflected in their birth weight or prematurity. STUDY DESIGN: In this retrospective case-control study, we evaluated whether women diagnosed with POI had a different birth weight or prematurity rate (<37 weeks) compared with women aged over 40 at natural menopause (the controls)...
February 2017: Maturitas
https://www.readbyqxmd.com/read/28034625/patient-specific-biodegradable-implant-in-pediatric-craniofacial-surgery
#10
H Essig, D Lindhorst, T Gander, P Schumann, D Könü, S Altermatt, M Rücker
Surgical correction of premature fusion of calvarial sutures involving the fronto-orbital region can be challenging due to the demanding three-dimensional (3D) anatomy. If fronto-orbital advancement (FOA) is necessary, surgery is typically performed using resorbable plates and screws that are bent manually intraoperatively. A new approach using individually manufactured resorbable implants (KLS Martin Group, Tuttlingen, Germany) is presented in the current paper. Preoperative CT scan data were processed in iPlan (ver...
November 30, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28026734/-callus-distraction-in-the-treatment-of-post-traumatic-defects-of-the-femur-and-tibia
#11
R Veselý, V Procházka
PURPOSE OF THE STUDY Evaluation of the results in patients treated for post-traumatic defects by the method of callus distraction of the femur and tibia using a monolateral external fixator. MATERIAL AND METHODS The group comprised 42 patients, 38 men and 4 woman, who underwent callus distraction using a monolateral external fixator in the Trauma Hospital Brno in the period from 2003 to 2010. The average age of the patients on the day gradual callus distraction was commenced was 32 (18-64) years. Post-traumatic bone defects were treated in 31 patients and deformities resulting from resection of post-traumatic infection loci in 11 patients...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28013296/thoracoabdominal-asynchrony-is-not-associated-with-oxyhemoglobin-saturation-in-recovering-premature-infants
#12
Colleen Brennan, Lara Ulm, Samuel Julian, Aaron Hamvas, Thomas Ferkol, Julie Hoffman, Laura Linneman, James Kemp
BACKGROUND: Recovering premature infants are at risk for hypoxemia and lack of synchrony between their rib cage and abdomen due to airflow obstruction and poor respiratory compliance. Thoracoabdominal asynchrony (TAA) is a useful marker of resistive and elastic lung properties. Whether TAA predicts oxygenation is unknown. OBJECTIVES: We investigated oxyhemoglobin saturation (SpO2%) and TAA (phase angle, φ) in preterm infants with/without high-humidity nasal cannula (HHNC)...
December 24, 2016: Neonatology
https://www.readbyqxmd.com/read/28011827/localization-of-premature-ventricular-contractions-from-the-papillary-muscles-using-the-standard-12-lead-electrocardiogram-a-feasibility-study-using-a-novel-cardiac-isochrone-positioning-system
#13
Peter M van Dam, Noel G Boyle, Michael M Laks, Roderick Tung
AIMS: The precise localization of the site of origin of a premature ventricular contraction (PVC) prior to ablation can facilitate the planning and execution of the electrophysiological procedure. In clinical practice, the targeted ablation site is estimated from the standard 12-lead ECG. The accuracy of this qualitative estimation has limitations, particularly in the localization of PVCs originating from the papillary muscles. Clinical available electrocardiographic imaging (ECGi) techniques that incorporate patient-specific anatomy may improve the localization of these PVCs, but require body surface maps with greater specificity for the epicardium...
December 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28009319/-ultrasound-monitoring-of-central-and-cerebral-hemodynamics-during-the-treatment-of-arterial-hypotension-in-preterm-infants
#14
A Zakrevskyy, O Karapetyan, V Agashkov, K Kosenko
The purpose of the study was to evaluate and identify patterns of changes in central and cerebral hemodynamics in neonates with low and extremely low birth weight and birth asphyxia, in order to achieve the early diagnosis of disorders of the central hemodynamics and autoregulation of cerebral blood flow, for timely fluid correction and inotropic therapy. Observation data on 44 preterm infants who were treated at the Kharkiv City Perinatal Centre and Regional Children's Clinical Hospital №1 of Kharkiv has been analyzed...
November 2016: Georgian Medical News
https://www.readbyqxmd.com/read/28003553/economics-of-home-monitoring-for-apnea-in-late-preterm-infants
#15
Brian L Montenegro, Michael Amberson, Lauren Veit, Christina Freiberger, Dmitry Dukhovny, Lawrence M Rhein
BACKGROUND: Apnea of prematurity affects a small proportion but large absolute number of late preterm infants, with out-patient management variably utilized despite relative clinical equipoise and potential for improved cost-effectiveness. METHODS: Over a 5-y period, from 2009 to 2013, infants born at ≥34 weeks gestational age at a level IIIB academic center in Boston, Massachusetts, with discharge-delaying apnea, bradycardia, and desaturation (ABD) events were identified...
January 2017: Respiratory Care
https://www.readbyqxmd.com/read/28002904/the-meniscus-vascularization-the-direct-correlation-with-tissue-composition-for-tissue-engineering-purposes
#16
A Di Giancamillo, L Mangiavini, I Tessaro, A Marmotti, R Scurati, G M Peretti
Meniscal lesions still represent an unsolved problem in clinical practice. Like the articular cartilage, meniscus has a scarce healing potential. Thus, when this tissue is damaged, the joint biomechanics is completely altered, leading to the development and progression of premature osteoarthritis. Therefore, in the last years, several tissue-engineering strategies have been developed to regenerate the meniscus with debated results. The comprehension of complex processes underlying meniscus maturation and structure is essential for a correct approach for the generation of a biomimetic meniscal substitute...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27991614/evaluation-of-the-winrop-system-for-identifying-retinopathy-of-prematurity-in-czech-preterm-infants
#17
Juraj Timkovic, Martina Pokryvkova, Katerina Janurova, Denisa Barinova, Renata Polackova, Petr Masek
AIMS: Retinopathy of Prematurity (ROP) is a potentially serious condition that can afflict preterm infants. Timely and correct identification of individuals at risk of developing a serious form of ROP is therefore of paramount importance. WinROP is an online system for predicting ROP based on birth weight and weight increments. However, the results vary significantly for various populations. It has not been evaluated in the Czech population. This study evaluates the test characteristics (specificity, sensitivity, positive and negative predictive values) of the WinROP system in Czech preterm infants...
December 13, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27977831/spectral-domain-optical-coherence-tomography-in-older-patients-with-history-of-retinopathy-of-prematurity
#18
Aristomenis Thanos, Yoshihiro Yonekawa, Bozho Todorich, Natalie Huang, Kimberly A Drenser, George A Williams, Michael T Trese, Antonio Capone
BACKGROUND AND OBJECTIVE: To characterize the in vivo microstructural features of patients with history of retinopathy of prematurity (ROP). PATIENTS AND METHODS: A single-center, retrospective imaging case series during which a chart review was performed of consecutive patients with history of ROP who underwent spectral-domain optical coherence tomography (SD-OCT) with or without enhanced depth imaging. Eyes with time-domain OCT, no light perception, or uninterpretable SD-OCT images were excluded...
December 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27957430/signaling-mechanisms-implicated-in-cranial-sutures-pathophysiology-craniosynostosis
#19
REVIEW
Maria A Katsianou, Christos Adamopoulos, Heleni Vastardis, Efthimia K Basdra
Normal extension and skull expansion is a synchronized process that prevails along the osteogenic intersections of the cranial sutures. Cranial sutures operate as bone growth sites allowing swift bone generation at the edges of the bone fronts while they remain patent. Premature fusion of one or more cranial sutures can trigger craniosynostosis, a birth defect characterized by dramatic manifestations in appearance and functional impairment. Up until today, surgical correction is the only restorative measure for craniosynostosis associated with considerable mortality...
December 2016: BBA Clinical
https://www.readbyqxmd.com/read/27928730/guided-growth-may-not-be-the-best-option-for-knee-valgus-deformity-in-adolescent-patients-with-morquio-a
#20
D Colmenares-Bonilla, M Vasconcelos-Martinez, J Guerra-Jasso, L Ocampo-Perez
INTRODUCTION: Valgus deformity in knees is a common concern in Morquio-A patients, preceding premature arthrosis and pain leading to walking disability and loss of ambulatory status. Treatment alternative is the guided growth, but this is sometimes not applied on time. Due to short height reached on these patients, not all will benefit from guided growth surgery. PURPOSE: The purpose of this study is to describe early results of physeal osteotomy for acute valgus correction in adolescent patients and those almost at height peak to achieve alignment...
December 7, 2016: Musculoskeletal Surgery
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