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JOURNAL ARTICLE
Nlandu-Roger Ngatu, Daniel-Kuezina Tonduangu, Emmanuel Munyeshyaka, Tomohiro Hirao, Georges-Matondo Balenda, Yusuke Yamadori, Takayuki Deguchi, Berthier Nsadi-Fwene, Jose-Nzunzu Lami, Steeve Akumwami, Kanae Kanda, Akitsu Murakami, Marie-Claire Yandju, Dieudonne-Tshipukane Nyembue, Antoine Tshimpi, Stanislas-Okitotsho Wembonyama
BACKGROUND: Air pollution and a number of metabolic disorders have been reported to increase the risk of severe COVID-19 outcomes. This study explored the association between severe COVID-19 outcomes, metabolic disorders and environmental air pollutants, at regional level, across 38 countries. METHODS: We conducted an ecological study using COVID-19 data related to countries of the Organization for Economic Cooperation and Development (OECD), with an estimated population of 1...
2024: Environmental Health and Preventive Medicine
#22
RANDOMIZED CONTROLLED TRIAL
Wassilios G Meissner, Philippe Remy, Caroline Giordana, David Maltête, Pascal Derkinderen, Jean-Luc Houéto, Mathieu Anheim, Isabelle Benatru, Thomas Boraud, Christine Brefel-Courbon, Nicolas Carrière, Hélène Catala, Olivier Colin, Jean-Christophe Corvol, Philippe Damier, Estelle Dellapina, David Devos, Sophie Drapier, Margherita Fabbri, Vanessa Ferrier, Alexandra Foubert-Samier, Solène Frismand-Kryloff, Aurore Georget, Christine Germain, Stéphane Grimaldi, Clémence Hardy, Lucie Hopes, Pierre Krystkowiak, Brice Laurens, Romain Lefaucheur, Louise-Laure Mariani, Ana Marques, Claire Marse, Fabienne Ory-Magne, Vincent Rigalleau, Hayet Salhi, Amandine Saubion, Simon R W Stott, Claire Thalamas, Claire Thiriez, Mélissa Tir, Richard K Wyse, Antoine Benard, Olivier Rascol
BACKGROUND: Lixisenatide, a glucagon-like peptide-1 receptor agonist used for the treatment of diabetes, has shown neuroprotective properties in a mouse model of Parkinson's disease. METHODS: In this phase 2, double-blind, randomized, placebo-controlled trial, we assessed the effect of lixisenatide on the progression of motor disability in persons with Parkinson's disease. Participants in whom Parkinson's disease was diagnosed less than 3 years earlier, who were receiving a stable dose of medications to treat symptoms, and who did not have motor complications were randomly assigned in a 1:1 ratio to daily subcutaneous lixisenatide or placebo for 12 months, followed by a 2-month washout period...
April 4, 2024: New England Journal of Medicine
#23
JOURNAL ARTICLE
Saleh A Alqahtani, Reem AlAhmed, Mariam M Hamza, Saleh A Alessy, Ada Alqunaibet, Amal AlGhammas, David Watkins, William Msemburi, Fadiah Alkhattabi, Sarah Pickersgill, Severin Rakic, Reem F Alsukait, Christopher H Herbst, Hazzaa M Al-Hazzaa
BACKGROUND: Insufficient physical activity (PA) was estimated to cause 4.8% of deaths and 2.6% of disability-adjusted life-years (DALYs) due to noncommunicable diseases in Saudi Arabia in 2019. While Saudi Arabia is already achieving great improvements, we predict the health and economic burden of insufficient PA up to 2040 to present a case for policy makers to invest more in the uptake of PA. METHODS: Using a population health model to estimate avoidable health loss, we identified four causes of health loss related to low PA (cardiovascular diseases, diabetes, breast cancer, and colorectal cancer) and estimated the deaths and DALYs from these causes...
2024: PloS One
#24
REVIEW
Mucio Tavares de Oliveira, Rui Baptista, Sergio A Chavez-Leal, Marcely Gimenes Bonatto
Heart failure (HF) is associated with disabling symptoms, poor quality of life, and a poor prognosis with substantial excess mortality in the years following diagnosis. Overactivation of the sympathetic nervous system is a key feature of the pathophysiology of HF and is an important driver of the process of adverse remodelling of the left ventricular wall that contributes to cardiac failure. Drugs which suppress the activity of the renin-angiotensin-aldosterone system, including β-blockers, are foundation therapies for the management of heart failure with reduced ejection fraction (HFrEF) and despite a lack of specific outcomes trials, are also widely used by cardiologist in patients with HF with preserved ejection fraction (HFpEF)...
2024: Current Medical Research and Opinion
#25
REVIEW
Alejandro Lorente, Leire Pelaz, Pablo Palacios, María Benlloch, José Enrique de la Rubia Ortí, Carlos Barrios, Gonzalo Mariscal, Rafael Lorente
Background : Evaluating the predictors of unfavorable outcomes in patients with ankle fractures is crucial for identifying high-risk patients and implementing personalized treatment strategies. This study aimed to analyze factors that influence quality of life in patients with ankle fractures. Methods : Four databases were consulted. The main outcomes were functionality and quality of life scales combined using the standard mean difference (SMD) (Review Manager 5.4). Results : Eight studies with 2486 patients were included...
February 20, 2024: Journal of Clinical Medicine
#26
JOURNAL ARTICLE
Xiao-Xiao Zhu, Kai-Feng Yao, Hai-Yan Huang, Li-Hua Wang
BACKGROUND: Type 2 diabetes mellitus (T2DM), a fast-growing issue in public health, is one of the most common chronic metabolic disorders in older individuals. Osteoporosis and sarcopenia are highly prevalent in T2DM patients and may result in fractures and disabilities. In people with T2DM, the association between nutrition, sarcopenia, and osteoporosis has rarely been explored. AIM: To evaluate the connections among nutrition, bone mineral density (BMD) and body composition in patients with T2DM...
March 15, 2024: World Journal of Diabetes
#27
JOURNAL ARTICLE
Xiaoyang Sun, Xinyu Yang, Xiaopeng Zhu, Yu Ma, Xu Li, Yuying Zhang, Qiling Liu, Chenmin Fan, Miao Zhang, Binger Xu, Yanlan Xu, Xin Gao, Jihong Dong, Mingfeng Xia, Hua Bian
BACKGROUND: Diabetic peripheral neuropathy (DPN) contributes to disability and imposes heavy burdens, while subclinical DPN is lack of attention so far. We aimed to investigate the relationship between vitamin D and distinct subtypes of subclinical DPN in type 2 diabetes (T2DM) patients. METHODS: This cross-sectional study included 3629 T2DM inpatients who undertook nerve conduction study to detect subclinical DPN in Zhongshan Hospital between March 2012 and December 2019...
2024: Frontiers in Endocrinology
#28
JOURNAL ARTICLE
Fikadu Ambaw Yehualashet, Dorothy Kessler, Segenet Bizuneh, Catherine Donnelly
BACKGROUND: Diabetes mellitus is the third most prevalent chronic metabolic disorder and a significant contributor to disability and impaired quality of life globally. Diabetes self-management coaching is an emerging empowerment strategy for individuals with type 2 diabetes, enabling them to achieve their health and wellness goals. The current study aims to determine the feasibility of a diabetes self-management coaching program and its preliminary effectiveness on the clinical and psychosocial outcomes in the Ethiopian primary healthcare context...
April 8, 2024: Pilot and Feasibility Studies
#29
Onur Ozturk, Nihan Hande Akcakaya, Mehmet Osman Akcakaya
Hemiballism/Hemichorea (HH) is a hyperkinetic movement disorder observed mostly after cerebrovascular diseases in elderly patients. Even though the improvement in symptoms would be maintained without treatment, in rare cases, lesioning or DBS (deep brain stimulation) surgery provide a chance on relieving the severe involuntary movements. HH is a more rarely reported entity as a diabetic complication and we encountered very few cases treated with surgical intervention for diabetic HH. A 75-year-old female patient with type-II diabetes mellitus was admitted for left-sided disabling involuntary movement despite being medically treated for six months...
April 7, 2024: Neurocirugía (English Edition)
#30
JOURNAL ARTICLE
Shaoxia Pu, Yaowen Liu, Wenjun Wu, Fei Sun, Hongsheng Lu, Xiaocui Xu, Yanhua Su, Wenming Cheng, Haizhen Wang
Age-related functional deterioration in skeletal muscle raises the risk for falls, disability, and mortality in the elderly, particularly in obese people or those with type 2 diabetes mellitus (T2D). However, the response of the skeletal muscle to transitioning from obesity to diabetes remains poorly defined, despite that obesity is classified as a stage of pre-diabetes. We screened and selected spontaneously obese and diabetic rhesus monkeys and examined altered protein expression in skeletal muscle of healthy aging (CON), obesity aging (OB), and type 2 diabetes mellitus aging (T2D) rhesus monkeys using Tandem Mass Tags (TMT)-based quantitative proteomic analysis...
April 15, 2024: Heliyon
#31
JOURNAL ARTICLE
M Lucía Fernández-Millones, Gianelli S Curi-Vilchez, Jose F Parodi, Fernando M Runzer-Colmenares
BACKGROUND: There is evidence that sarcopenia and functionality are closely related. However, the association between geriatric syndromes, such as dependence, on instrumental activities and sarcopenia could be affected by the presence of certain comorbidities, such as overweight, obesity, diabetes, and chronic obstructive pulmonary disease (COPD). Therefore, the present study aimed to determine the association between instrumental activities of daily living and muscle mass in the elderly and evaluate the impact of certain comorbidities on this association...
April 8, 2024: Annals of geriatric medicine and research
#32
REVIEW
I-Weng Yen, Hung-Yuan Li
Vascular adhesion protein-1 (VAP-1) plays a dual role with its adhesive and enzymatic properties, facilitating leukocyte migration to sites of inflammation and catalyzing the breakdown of primary amines into harmful by-products, which are linked to diabetic complications. Present in various tissues, VAP-1 also circulates in a soluble form in the bloodstream. Diabetes is associated with several complications such as cardiovascular disease, retinopathy, nephropathy, and neuropathy, significantly contributing to disability and mortality...
April 6, 2024: Journal of Diabetes Investigation
#33
JOURNAL ARTICLE
Marie Balslev Backe, Per Kallestrup, Kurt Rasmussen, Marit Eika Jørgensen, Michael Lynge Pedersen
INTRODUCTION: Noncommunicable diseases (NCDs) constitute a massive global burden and are the leading cause of death and disability worldwide. In Greenland, the prevalence of NCDs has historically been low. However, during the past approximately 70 years, life circumstances have changed dramatically resulting in increased life expectancy. Today, the proportion of inhabitants in Greenland ≥65 years has nearly tripled since the 1980s, and the prevalence of obesity and diabetes has increased rapidly within the past decades...
April 5, 2024: Scandinavian Journal of Primary Health Care
#34
JOURNAL ARTICLE
Yi-Jia Guo, Xin-Ling Gan, Ru-Yun Zhang, Yong Liu, Er-Li Wang, Shui-Hua Lu, Hui Jiang, Hong-Fei Duan, Zheng-Zhou Yuan, Wei-Min Li
BACKGROUND: The underlying mechanism for stroke in patients with tuberculous meningitis (TBM) remains unclear. This study aimed to investigate the predictors of acute ischemic stroke (AIS) in TBM and whether AIS mediates the relationship between inflammation markers and functional disability. METHODS: TBM patients admitted to five hospitals between January 2011 and December 2021 were consecutively observed. Generalized linear mixed model and subgroup analyses were performed to investigate predictors of AIS in patients with and without vascular risk factors (VAFs)...
2024: Frontiers in Public Health
#35
JOURNAL ARTICLE
Daris Francis, Kandaswami Kotteeswaran, Pramod Padinhare Veedu
BACKGROUND AND OBJECTIVES: The widespread presence of diabetic peripheral neuropathy (DN) and its related variables among diagnosed diabetes mellitus (DM) patients in Kerala lacks sufficient evidence. The objective of this study was to evaluate the frequency of DN and its related risk variables among those with DM who were receiving care at a tertiary health institution in Kerala. MATERIALS AND METHODS: This study was conducted in a tertiary health center in Kerala using a cross-sectional design...
March 2024: Curēus
#36
JOURNAL ARTICLE
Owen Nkoka, Shekinah Munthali-Mkandawire, Kondwani Mwandira, Providence Nindi, Albert Dube, Innocent Nyanjagha, Angella Mainjeni, Jullita Malava, Abena S Amoah, Estelle McLean, Robert C Stewart, Amelia C Crampin, Alison J Price
In low-income Africa, the epidemiology of physical multimorbidity and associated mental health conditions is not well described. We investigated the multimorbidity burden, disease combinations, and relationship between physical multimorbidity and common mental health disorders in rural and urban Malawi using early data from 9,849 adults recruited to an on-going large cross-sectional study on long-term conditions, initiated in 2021. Multimorbidity was defined as having two or more measured (diabetes, hypertension) or self-reported (diabetes, hypertension, disability, chronic pain, HIV, asthma, stroke, heart disease, and epilepsy) conditions...
2024: PLOS Glob Public Health
#37
JOURNAL ARTICLE
Moein Moghaddam Ahmadi, Mohammad Taghi Ashoobi, Zohreh Darabi, Hossein Ramezannezhad, Mahta Moghaddam Ahmadi
Diabetic foot ulcers (DFUs) pose a significant clinical challenge, often leading to amputations and hospitalisation. This study aimed to investigate the characteristics and outcomes of DFUs treated with surgical debridement and standardised wound care. This descriptive cross-sectional study focused on diabetic patients with appropriate vascular conditions, as determined by an Ankle Brachial Index >0.9. Based on their infection status, participants were admitted to Poursina Hospital in Rasht, Iran, and subjected to initial supportive measures, antibiotic therapy and surgical debridement...
April 2024: International Wound Journal
#38
Melanie Ayers
Adults with intellectual disabilities (ID) experience age-related diseases, such as diabetes, hypertension, cardiovascular disease, and obesity much earlier than their typical peers. Therefore, health promotion is essential in this population.1 This population tends to live sedentary lives; exercise needs to be a focus. Exercise positively impacts survival rates for those with ID.2 Motivation and support are vital factors to successfully incorporate exercise into their lives. Prevalent barriers are a lack of access to health promotion programs, support, and transportation...
March 2024: Delaware journal of public health
#39
JOURNAL ARTICLE
Igor Kazadi Kabanda, Credo Kiangebeni Ngonzo, Christian-Khalifa Emeka Bowamou, Jean-Paul Divengi Nzambi, Nono Kiatoko Ponte, Olivier Tuyinama Madoda, Aliocha Nkodila Natuhoyila, Jean-René M'buyamba-Kabangu, Benjamin Longo-Mbenza, Degani Banzulu Bomba, Bernard Kianu Phanzu
BACKGROUND: Rapid recognition and early medical intervention are essential to reduce stroke-related mortality and long-term disability. This study aimed to evaluate awareness of stroke symptoms/signs and determine factors delaying the hospital arrival of patients with acute stroke in Kinshasa. METHODS: Patients with stroke and/or accompanying family members were interviewed using a standard questionnaire, and their medical records were reviewed. Factors independently associated with a late arrival (≥4...
April 15, 2024: Heliyon
#40
JOURNAL ARTICLE
Luisa Schertel Cassiano, Fábio R M Leite, Silas Alves-Costa, Susilena Arouche Costa, Gustavo G Nascimento
AIM: To explore the association between oral conditions and their interaction with salt taste disability among American adults. METHODS: Data from the 2013-2014 NHANES cycle were used (n = 2373). The exposures were periodontitis, defined by the 2017 EFP-AAP classification, dental caries, missing teeth, and edentulism, as per the DMF-T index, and xerostomia. The outcome was salt taste disability, objectively assessed. Covariates included sex, age, educational level, poverty index, obesity, diabetes, smoking, alcohol consumption, and medications related to mouth dryness...
April 2, 2024: Oral Diseases
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