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https://www.readbyqxmd.com/read/28528738/our-initial-experience-with-ventriculo-epiplooic-shunt-in-treatment-of-hydrocephalus-in-two-centers
#1
Valentin Titus Grigorean, Aurelia Mihaela Sandu, Mihai Popescu, Ioan Stefan Florian, Cristian Dumitru Lupascu, Corina Lupascu Ursulescu
INTRODUCTION: Hydrocephalus represents impairment in cerebrospinal fluid (CSF) dynamics. If the treatment of hydrocephalus is considered difficult, the repeated revisions of ventriculo-peritoneal (VP) shunts are even more challenging. OBJECTIVE: The aim of this article is to evaluate the efficiency of ventriculo-epiplooic (VEp) shunt as a feasible alternative in hydrocephalic patients. MATERIAL AND METHODS: A technical modification regarding the insertion of peritoneal catheter was imagined: midline laparotomy 8-10cm long was performed in order to open the peritoneal cavity; the great omentum was dissected between its two layers; we placed the distal end of the catheter between the two epiplooic layers; a fenestration of 4cm in diameter into the visceral layer was also performed...
May 11, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28523294/autophagy-in-aging-and-disease
#2
Mădălina Fîlfan, Raluca Elena Sandu, Alexandra Daniela Zăvăleanu, Andrei GreşiŢă, Daniela Gabriela Glăvan, Denissa Greta Olaru, Aurel Popa-Wagner
Autophagy is a catabolic degradation system used to destroy and recycle the unnecessary or damaged components of a cell. Autophagy is present at a basal level in all mammals and is regulated by some conditions, such as oxidative stress, starvation or hypoxia. In aged tissues, increased but also decreased expression of autophagy-specific proteins, Beclin 1, LC3, Atg5 and Atg7 has been reported. Likewise, it could be shown that the lifespan of yeast, nematodes and flies is prolonged by pharmacologically stimulated autophagy using exogenous administered spermidine...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28443268/complicated-postoperative-course-after-pulmonary-artery-sling-repair-and-slide-tracheoplasty
#3
Angelika Weber, Birgit Donner, Marie-Hélène Perez, Stefano Di Bernardo, Daniel Trachsel, Kishore Sandu, Nicole Sekarski
Pulmonary artery sling (PAS) is a rare congenital condition in which the left pulmonary artery (LPA) arises from the right pulmonary artery, and then passes between the trachea and the esophagus to reach the left lung, thereby forming a sling around the airway. It is often associated with intrinsic tracheal stenosis due to complete cartilaginous rings. Therapeutic management nowadays consists of one-stage reimplantation of the LPA and tracheoplasty with cardiopulmonary bypass support. Here, we present a 7-week-old boy with PAS and long-segment tracheal stenosis (LSTS) who underwent surgical intervention consisting of reimplantation of the LPA and slide tracheoplasty...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28413344/analytical-results-regarding-electrostatic-resonances-of-surface-phonon-plasmon-polaritons-separation-of-variables-with-a-twist
#4
R C Voicu, T Sandu
The boundary integral equation (BIE) method ascertains explicit relations between localized surface phonon and plasmon polariton resonances and the eigenvalues of its associated electrostatic operator. We show that group-theoretical analysis of the Laplace equation can be used to calculate the full set of eigenvalues and eigenfunctions of the electrostatic operator for shapes and shells described by separable coordinate systems. These results not only unify and generalize many existing studies, but also offer us the opportunity to expand the study of phenomena such as cloaking by anomalous localized resonance...
March 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28193123/ventriculoportal-shunt-a-new-transomphalic-extraperitoneal-surgical-technique-in-treatment-of-hydrocephalus
#5
Valentin Titus Grigorean, Aurelia Mihaela Sandu, Mihai Popescu, Victor Strambu
AIM: The aim of this article was to report a new transomphalic extraperitoneal surgical technique for treatment of hydrocephalus, called ventriculoportal shunt. MATERIALS AND METHODS: We performed ventriculoportal shunt on an experimental animal (pig). The particularity of ventriculoportal shunt consists in the fact that the distal end of the catheter is inserted transomphalic extraperitoneally in the portal system through reopened umbilical vein. We present technical details regarding this new surgical technique...
June 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28159008/unravelling-networks-in-local-public-health-policymaking-in-three-european-countries-a-systems-analysis
#6
Hilde P E M Spitters, Cathrine J Lau, Petru Sandu, Marcel Quanjel, Diana Dulf, Charlotte Glümer, Hans A M van Oers, Ien A M van de Goor
BACKGROUND: Facilitating and enhancing interaction between stakeholders involved in the policymaking process to stimulate collaboration and use of evidence, is important to foster the development of effective Health Enhancing Physical Activity (HEPA) policies. Performing an analysis of real-world policymaking processes will help reveal the complexity of a network of stakeholders. Therefore, the main objectives were to unravel the stakeholder network in the policy process by conducting three systems analyses, and to increase insight into the similarities and differences in the policy processes of these European country cases...
February 3, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28149941/a-comparison-of-measurement-methods-of-hippocampal-atrophy-rate-for-predicting-alzheimer-s-dementia-in-the-aberdeen-birth-cohort-of-1936
#7
Arnab K Rana, Anca-Larisa Sandu, Kenna L Robertson, Christopher J McNeil, Lawrence J Whalley, Roger T Staff, Alison D Murray
INTRODUCTION: Various methods are available to measure hippocampal atrophy rate. We compared methods to predict Alzheimer's dementia. METHODS: Participants with brain imaging at ages 69 and 73 years were identified from a previous study. Simple manual measures and computationally automated volumetry were performed. Receiver operating characteristics assessed the predictive ability of each method at baseline and on logit regression analysis of two serial scans. RESULTS: Ten of 149 participants developed Alzheimer's dementia and had lower baseline volumes (3647 vs...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28139253/determinants-of-evidence-use-in-public-health-policy-making-results-from-a-study-across-six-eu-countries
#8
Ien van de Goor, Riitta-Maija Hämäläinen, Ahmed Syed, Cathrine Juel Lau, Petru Sandu, Hilde Spitters, Leena Eklund Karlsson, Diana Dulf, Adriana Valente, Tommaso Castellani, Arja R Aro
The knowledge-practice gap in public health is widely known. The importance of using different types of evidence for the development of effective health promotion has also been emphasized. Nevertheless, in practice, intervention decisions are often based on perceived short-term opportunities, lacking the most effective approaches, thus limiting the impact of health promotion strategies. This article focuses on facilitators and barriers in the use of evidence in developing health enhancing physical activity policies...
January 20, 2017: Health Policy
https://www.readbyqxmd.com/read/28121201/trigeminocardiac-reflex-in-cerebrovascular-surgery-a-review-and-an-attempt-of-a-predictive-analysis
#9
REVIEW
Nora Sandu, Tumul Chowdhury, Cyrill Meuwly, Bernhard Schaller
Trigemino-cardiac reflex (TCR) is a well-established neurogenic reflex that is primarily observed in many neurosurgical procedures, especially skull base surgery. Few management strategies have been highlighted in the literature; however, controversies still exist related to this topic. Areas covered: The authors present for the first time the results of a multivariable analysis to predict the TCR during cerebrovascular surgery. However, such first statistical results have not yet any impact on the treatment of the TCR, as correlation is not the cause...
March 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28099335/micronodular-pattern-of-organizing-pneumonia-case-report-and-systematic-literature-review
#10
REVIEW
François Lebargy, Davy Picard, Jean Hagenburg, Olivier Toubas, Jeanne-Marie Perotin, Sebastian Sandu, Gaëtan Deslee, Sandra Dury
RATIONALE: Organizing pneumonia (OP) is a clinicopathological entity characterized by granulation tissue plugs in the lumen of small airways, alveolar ducts, and alveoli. OP can be cryptogenic (primary) (COP) or secondary to various lung injuries. PATIENT CONCERNS: We report the case of a 38-year-old male smoker with COP presenting in the form of diffuse micronodules on computed tomography (CT) scan and describe the clinical, radiological, and functional characteristics of micronodular pattern of organizing pneumonia (MNOP) based on a review of the literature including 14 cases...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28093317/stem-cell-therapies-in-preclinical-models-of-stroke-is-the-aged-brain-microenvironment-refractory-to-cell-therapy
#11
Raluca Elena Sandu, Adrian Tudor Balseanu, Catalin Bogdan, Mark Slevin, Eugen Petcu, Aurel Popa-Wagner
Stroke is a devastating disease demanding vigorous search for new therapies. Initial enthusiasm to stimulate restorative processes in the ischemic brain by means of cell-based therapies has meanwhile converted into a more balanced view recognizing impediments that may be related to unfavorable age-associated environments. Recent results using a variety of drug, cell therapy or combination thereof suggest that, (i) treatment with Granulocyte-Colony Stimulating Factor (G-CSF) in aged rats has primarily a beneficial effect on functional outcome most likely via supportive cellular processes such as neurogenesis; (ii) the combination therapy, G-CSF with mesenchymal cells (G-CSF+BM-MSC or G-CSF+BM-MNC) did not further improve behavioral indices, neurogenesis or infarct volume as compared to G-CSF alone in aged animals; (iii) better results with regard to integration of transplanted cells in the aged rat environment have been obtained using iPS of human origin; (iv) mesenchymal cells may be used as drug carriers for the aged post-stroke brains...
January 14, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28048293/su-f-t-605-implementation-of-the-conformity-gradient-index-cgi-to-intracranial-linac-based-stereotactic-plans-to-evaluate-possible-improvements-in-treatment-planning
#12
A Sandu, S Thompson, A Ayan, J Woollard, N Gupta
PURPOSE: To retrospectively evaluate the planning quality of a sample of intracranial, linac-based, dynamic arc MLC and VMAT stereotactic plans by calculating the effective gradient, Conformity Score (CGIc) and Gradient Score Index (CGIg), and determine if the Conformity/Gradient Index (CGI) may be a useful metric to guide our current treatment planning process. METHODS: We evaluated single lesion VMAT, single lesion dynamic arc, and single isocenter, 2-lesion linac-based, intracranial, VMAT treatment plans originally created in Eclipse™...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27881131/an-evaluation-of-equity-and-equality-in-physical-activity-policies-in-four-european-countries
#13
Riitta-Maija Hämäläinen, Petru Sandu, Ahmed M Syed, Mette W Jakobsen
BACKGROUND: There is strong research evidence on the importance of health equity and equality for wellbeing in societies. As chronic non-communicable diseases are widespread, the positive impact of physical activity (PA) on health has gained importance. However, PA at the population level is far from optimal. PA depends not only on individual factors, but also on policies for PA in sport, health, transport, education and other sectors, on social and cultural factors, and on the environment...
November 24, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27826458/factors-influencing-the-incidence-of-severe-complications-in-head-and-neck-free-flap-reconstructions
#14
Martin Broome, Naline Juilland, Yann Litzistorf, Yan Monnier, Kishore Sandu, Philippe Pasche, Peter K Plinkert, Philippe A Federspil, Christian Simon
BACKGROUND: Complications after head and neck free-flap reconstructions are detrimental and prolong hospital stay. In an effort to identify related variables in a tertiary regional head and neck unit, the microvascular reconstruction activity over the last 5 years was captured in a database along with patient-, provider-, and volume-outcome-related parameters. METHODS: Retrospective cohort study (level of evidence 3), a modified Clavien-Dindo classification, was used to assess severe complications...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27681009/-housing-first-for-homeless-youth-with-mental-illness
#15
Nicole Kozloff, Carol E Adair, Luis I Palma Lazgare, Daniel Poremski, Amy H Cheung, Rebeca Sandu, Vicky Stergiopoulos
BACKGROUND AND OBJECTIVES: "Housing First" has been shown to improve housing stability in homeless individuals with mental illness, but had not been empirically tested in homeless youth. We aimed to evaluate the effect of "Housing First" on housing stability in homeless youth aged 18 to 24 years participating in At Home/Chez Soi, a 24-month randomized trial of "Housing First" in 5 Canadian cities. METHODS: Homeless individuals with mental illness were randomized to receive "Housing First" (combined with assertive community treatment or intensive case management depending on their level of need) or treatment as usual...
October 2016: Pediatrics
https://www.readbyqxmd.com/read/27668040/impacts-of-parameterized-orographic-drag-on-the-northern-hemisphere-winter-circulation
#16
Irina Sandu, Peter Bechtold, Anton Beljaars, Alessio Bozzo, Felix Pithan, Theodore G Shepherd, Ayrton Zadra
A recent intercomparison exercise proposed by the Working Group for Numerical Experimentation (WGNE) revealed that the parameterized, or unresolved, surface stress in weather forecast models is highly model-dependent, especially over orography. Models of comparable resolution differ over land by as much as 20% in zonal mean total subgrid surface stress (τtot ). The way τtot is partitioned between the different parameterizations is also model-dependent. In this study, we simulated in a particular model an increase in τtot comparable with the spread found in the WGNE intercomparison...
March 2016: Journal of Advances in Modeling Earth Systems
https://www.readbyqxmd.com/read/27569547/impaired-presynaptic-high-affinity-choline-transporter-causes-a-congenital-myasthenic-syndrome-with-episodic-apnea
#17
Stéphanie Bauché, Seana O'Regan, Yoshiteru Azuma, Fanny Laffargue, Grace McMacken, Damien Sternberg, Guy Brochier, Céline Buon, Nassima Bouzidi, Ana Topf, Emmanuelle Lacène, Ganaelle Remerand, Anne-Marie Beaufrere, Céline Pebrel-Richard, Julien Thevenon, Salima El Chehadeh-Djebbar, Laurence Faivre, Yannis Duffourd, Federica Ricci, Tiziana Mongini, Chiara Fiorillo, Guja Astrea, Carmen Magdalena Burloiu, Niculina Butoianu, Carmen Sandu, Laurent Servais, Gisèle Bonne, Isabelle Nelson, Isabelle Desguerre, Marie-Christine Nougues, Benoit Bœuf, Norma Romero, Jocelyn Laporte, Anne Boland, Doris Lechner, Jean-François Deleuze, Bertrand Fontaine, Laure Strochlic, Hanns Lochmuller, Bruno Eymard, Michèle Mayer, Sophie Nicole
The neuromuscular junction (NMJ) is one of the best-studied cholinergic synapses. Inherited defects of peripheral neurotransmission result in congenital myasthenic syndromes (CMSs), a clinically and genetically heterogeneous group of rare diseases with fluctuating fatigable muscle weakness as the clinical hallmark. Whole-exome sequencing and Sanger sequencing in six unrelated families identified compound heterozygous and homozygous mutations in SLC5A7 encoding the presynaptic sodium-dependent high-affinity choline transporter 1 (CHT), which is known to be mutated in one dominant form of distal motor neuronopathy (DHMN7A)...
September 1, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27522662/laser-supraglottoplasty-for-laryngomalacia-a-14%C3%A2-year-experience-of-a-tertiary-referral-center
#18
Antoine Reinhard, François Gorostidi, Crispin Leishman, Philippe Monnier, Kishore Sandu
To review the outcomes of laser supraglottoplasty performed in children with symptomatic laryngomalacia and determine the factors influencing them. We retrospectively reviewed the medical records of patients who underwent laser supraglottoplasty for symptomatic laryngomalacia at the Lausanne University Hospital from November 2001 to November 2014. We examined the patient's demography, symptoms, comorbidities, type of laryngomalacia, synchronous airway lesions, and final outcomes. Seventy-nine patients were included in this study; median age at the time of surgery was 12...
January 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27516006/molecular-mechanisms-underlying-neurodevelopmental-disorders-adhd-and-autism
#19
REVIEW
George Mihai Bădescu, Mădălina Fîlfan, Raluca Elena Sandu, Roxana Surugiu, Ovidiu Ciobanu, Aurel Popa-Wagner
Neurodevelopmental disorders such as attention deficit hyperactivity disorder and autism represent a significant economic burden, which justify vigorous research to uncover its genetics and developmental clinics for a diagnostic workup. The urgency of addressing attention deficit hyperactivity disorder comorbidities is seen in the chilling fact that attention deficit hyperactivity disorder (ADHD), mood disorders, substance use disorders and obesity each increase the risk for mortality. However, data about comorbidity is mainly descriptive, with mechanistic studies limited to genetic epidemiological studies that document shared genetic risk factors among these conditions...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27507433/controlled-creation-and-displacement-of-charged-domain-walls-in-ferroelectric-thin-films
#20
L Feigl, T Sluka, L J McGilly, A Crassous, C S Sandu, N Setter
Charged domain walls in ferroelectric materials are of high interest due to their potential use in nanoelectronic devices. While previous approaches have utilized complex scanning probe techniques or frustrative poling here we show the creation of charged domain walls in ferroelectric thin films during simple polarization switching using either a conductive probe tip or patterned top electrodes. We demonstrate that ferroelectric switching is accompanied - without exception - by the appearance of charged domain walls and that these walls can be displaced and erased reliably...
2016: Scientific Reports
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