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https://www.readbyqxmd.com/read/29319013/intraoperative-cardiovascular-response-of-natural-orifice-transluminal-endoscopic-surgery-versus-laparoscopy-a-comparative-animal-study
#1
Stefan Patrascu, Catalin Andu Copaescu, Valeriu Surlin, Sandu Ramboiu, Alice Nicoleta Dragoescu, Sorin Stanilescu, Dan Cristian, Bogdan Silviu Ungureanu, Daniela Elena Burtea, Ana Maria Patrascu, Florin Turcu, Adrian Saftoiu
BACKGROUND: Natural orifice transluminal endoscopic surgery (NOTES) emerged as a new alternative method in minimally invasive techniques. Although a very small number of studies have compared the physiologic response in NOTES to laparoscopy, the results remain controversial. AIM: This experimental animal study aims to evaluate the intraoperative cardiovascular and respiratory effects of pure transluminal natural orifice surgery and conventional laparoscopy. MATERIALS AND METHODS: Twenty female pigs (Sus scrofa domesticus) equally divided into two study groups were assigned to either pure natural orifice transluminal endoscopic techniques (Group 1) or conventional laparoscopic surgery (Group 2) and monitored intraoperatively in terms of heart rate (HR), systolic blood pressure (SBP) and O2saturation (SpO2) for 1 h...
January 10, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29286319/cellular-and-molecular-mechanisms-underlying-non-pharmaceutical-ischemic-stroke-therapy-in-aged-subjects
#2
REVIEW
Raluca Elena Sandu, Danut Dumbrava, Roxana Surugiu, Daniela-Gabriela Glavan, Andrei Gresita, Eugen Bogdan Petcu
The incidence of ischemic stroke in humans increases exponentially above 70 years both in men and women. Comorbidities like diabetes, arterial hypertension or co-morbidity factors such as hypercholesterolemia, obesity and body fat distribution as well as fat-rich diet and physical inactivity are common in elderly persons and are associated with higher risk of stroke, increased mortality and disability. Obesity could represent a state of chronic inflammation that can be prevented to some extent by non-pharmaceutical interventions such as calorie restriction and hypothermia...
December 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29258483/developing-a-policy-game-intervention-to-enhance-collaboration-in-public-health-policymaking-in-three-european-countries
#3
H P E M Spitters, J A M van Oers, P Sandu, C J Lau, M Quanjel, D Dulf, R Chereches, L A M van de Goor
No abstract text is available yet for this article.
December 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29163001/implantation-of-3d-constructs-embedded-with-oral-mucosa-derived-cells-induces-functional-recovery-in-rats-with-complete-spinal-cord-transection
#4
Javier Ganz, Erez Shor, Shaowei Guo, Anton Sheinin, Ina Arie, Izhak Michaelevski, Sandu Pitaru, Daniel Offen, Shulamit Levenberg
Spinal cord injury (SCI), involving damaged axons and glial scar tissue, often culminates in irreversible impairments. Achieving substantial recovery following complete spinal cord transection remains an unmet challenge. Here, we report of implantation of an engineered 3D construct embedded with human oral mucosa stem cells (hOMSC) induced to secrete neuroprotective, immunomodulatory, and axonal elongation-associated factors, in a complete spinal cord transection rat model. Rats implanted with induced tissue engineering constructs regained fine motor control, coordination and walking pattern in sharp contrast to the untreated group that remained paralyzed (42 vs...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29106858/congenital-pharyngeal-webs-treatment-of-a-rare-clinical-entity-by-endoscopic-co2-laser-approach
#5
Grégoire B Morand, Karma Lambercy, Pierre Guilcher, Kishore B Sandu
IMPORTANCE: Oesophageal inlet stenosis can promote dysphagia and aspiration. We report the cases of syndromic children with congenital pharyngeal webs successfully treated with endoscopic CO2 laser. OBSERVATIONS: Pharyngeal webs were excised with CO2 laser (Ultrapulse mode) and resurfaced using mucosal advancement flaps to avoid restenosis and/or formation of secondary synechia. This led to a significant enlargement of the oesophageal inlet, which was documented immediately postoperatively and the clinical improvement of dysphagia and decreased aspiration persisted at distant follow-up...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29106439/increased-diastolic-blood-pressure-is-associated-with-mri-biomarkers-of-dementia-related-brain-pathology-in-normative-ageing
#6
Christopher J McNeil, Phyo Kyaw Myint, Anca-Larisa Sandu, John F Potter, Roger Staff, Lawrence J Whalley, Alison D Murray
Background: hypertension is a risk for brain ageing, but the mechanisms underlying this effect remain unclear. Magnetic resonance imaging (MRI) detected biomarkers of brain ageing include white matter hyperintensities (WMHs), a marker of cerebrovascular disease, and hippocampal volume, a marker of Alzheimer's disease pathology. Objective: to examine relationships between blood pressure (BP) components and brain pathology in older adults. Subjects: two hundred and twenty-seven members of the Aberdeen 1936 Birth Cohort between ages 64 and 68 years...
January 1, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29075983/temporary-tracheal-stenting-using-endovascular-prosthesis-in-the-management-of-severe-refractory-stenosis-following-slide-tracheoplasty
#7
Kishore Sandu, Antoine Reinhard, Karma Lambercy, Rene Pretre, Francois Gorostidi
OBJECTIVES: To evaluate the role of endovascular stents in temporary tracheal stenting and endoscopic treatment strategy for patients with severe refractory tracheal stenosis following slide tracheoplasty. METHODS: Two patients had severe tracheal stenosis after slide tracheoplasty for long segment congenital tracheal stenosis. Both these patients were managed endoscopically and an endovascular prosthesis was used to temporarily stent the trachea. Short and long term results were evaluated clinically and with repeated endoscopies...
October 26, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29038859/refashioned-lamb-tissue-as-an-animal-model-for-training-complex-techniques-of-laryngotracheal-stenosis-surgery
#8
Lluís Nisa, Pedro Teiga, Gustavo Barreto da Cunha, Biswanath Roy, Riza Onder Gunaydin, Kishore Sandu
Open reconstructive upper airway surgery for laryngotracheal stenosis (LTS), whether for subglottic or tracheal stenosis, constitutes a group of complex approaches. LTS requiring open reconstruction is overall rare and primarily performed at tertiary centres. This poses an obvious challenge for the acquisition and maintenance of surgical skills for this group of complex approaches. In this context, animal models provide a unique opportunity for open reconstructive airway surgery training. Such models ought to take into consideration ethical aspects, be easily available and easy to maintain, and have similar macroscopic anatomical features to the human laryngotracheal frame...
December 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28961383/caloric-restriction-stabilizes-body-weight-and-accelerates-behavioral-recovery-in-aged-rats-after-focal-ischemia
#9
Ovidiu Ciobanu, Raluca Elena Sandu, Adrian Tudor Balseanu, Alexandra Zavaleanu, Andrei Gresita, Eugen Bogdan Petcu, Adriana Uzoni, Aurel Popa-Wagner
Obesity and hyperinsulinemia are risk factors for stroke. We tested the hypothesis that caloric restriction, which reduces the incidence of age-related obesity and metabolic syndrome, may represent an efficient and cost-effective strategy for preventing stroke and its devastating consequences. To this end, we placed aged, obese Sprague-Dawley aged rats on a calorie-restricted diet for 8 weeks prior to the experimental infarction. Stroke in this animal model caused a progressive decrease in weight that reached a minimum at day 6 for the young rats, and at day 10 for the aged, ad libitum-fed rats...
December 2017: Aging Cell
https://www.readbyqxmd.com/read/28921522/extraluminal-biodegradable-splint-to-treat-upper-airway-anterior-malacia-a-preclinical-proof-of-principle
#10
François Gorostidi, Cécile Courbon, Marco Burki, Antoine Reinhard, Kishore Sandu
OBJECTIVE: Upper airway malacia highly complicates the treatment of benign laryngotracheal stenosis, and no ideal option is available to date. We here explore the use of extraluminal biodegradable splints in an animal model of long-segment anterior tracheomalacia (TM). We show the efficacy, as well as the tissue tolerance, of a custom-made biodegradable extraluminal device surgically inserted around the trachea. STUDY DESIGN: Preclinical animal study. METHODS: Anterior TM was induced in rabbits through an anterior neck approach by removing eight consecutive anterior tracheal rings without damaging the underlying mucosa...
September 16, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28910075/mechanochemical-synthesis-of-pedot-pss-hydrogels-for-aqueous-formulation-of-li-ion-battery-electrodes
#11
Georgiana Sandu, Bruno Ernould, Julien Rolland, Nathalie Cheminet, Jérémy Brassinne, Pratik R Das, Yaroslav Filinchuk, Luhua Cheng, Lidiya Komsiyska, Philippe Dubois, Sorin Melinte, Jean-François Gohy, Roberto Lazzaroni, Alexandru Vlad
Water-soluble binders can enable greener and cost-effective Li-ion battery manufacturing by eliminating the standard fluorine-based formulations and associated organic solvents. The issue with water-based dispersions, however, remains the difficulty in stabilizing them, requiring additional processing complexity. Herein, we show that mechanochemical conversion of a regular poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) water-based dispersion produces a hydrogel that meets all the requirements as binder for lithium-ion battery electrode manufacture...
October 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28860128/opioid-receptor-activation-impairs-hypoglycemic-counterregulation-in-humans
#12
Michelle Carey, Rebekah Gospin, Akankasha Goyal, Nora Tomuta, Oana Sandu, Armand Mbanya, Eric Lontchi-Yimagou, Raphael Hulkower, Harry Shamoon, Ilan Gabriely, Meredith Hawkins
Although intensive glycemic control improves outcomes in type 1 diabetes mellitus (T1DM), iatrogenic hypoglycemia limits its attainment. Recurrent and/or antecedent hypoglycemia causes blunting of protective counterregulatory responses, known as hypoglycemia-associated autonomic failure (HAAF). To determine whether and how opioid receptor activation induces HAAF in humans, 12 healthy subjects without diabetes (7 men, age 32.3 ± 2.2 years, BMI 25.1 ± 1.0 kg/m(2)) participated in two study protocols in random order over two consecutive days...
November 2017: Diabetes
https://www.readbyqxmd.com/read/28829051/dopamine-transporter-and-reward-anticipation-in-a-dimensional-perspective-a-multimodal-brain-imaging-study
#13
Manon Dubol, Christian Trichard, Claire Leroy, Anca-Larisa Sandu, Mehdi Rahim, Bernard Granger, Eleni T Tzavara, Laurent Karila, Jean-Luc Martinot, Eric Artiges
Dopamine function and reward processing are highly interrelated and involve common brain regions afferent to the Nucleus Accumbens, within the mesolimbic pathway. While dopamine function and reward system neural activity are impaired in most psychiatric disorders, it is unknown if alterations in the dopamine system underlie variations in reward processing across a continuum encompassing health and these disorders. We explored the relationship between dopamine function and neural activity during reward anticipation in twenty-seven participants including healthy volunteers and psychiatric patients with schizophrenia, depression or cocaine addiction, using functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) multimodal imaging with a voxel-based statistical approach...
August 22, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28792656/amygdala-and-regional-volumes-in-treatment-resistant-versus-nontreatment-resistant-depression-patients
#14
Anca-Larisa Sandu, Eric Artiges, André Galinowski, Thierry Gallarda, Frank Bellivier, Hervé Lemaitre, Bernard Granger, Damien Ringuenet, Eleni T Tzavara, Jean-Luc Martinot, Marie-Laure Paillère Martinot
BACKGROUND: Although treatment-resistant and nontreatment-resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented. METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls...
August 9, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28730223/histopathological-diagnosis-and-its-correlations-with-anatomoclinical-features-surgical-approach-and-postoperative-prognosis-in-sacral-tumors
#15
Oana Ilona David, Corina Veronica Lupaşcu-Ursulescu, Cristian Dumitru Lupaşcu, Aurelia Mihaela Sandu, Victor Dan Eugen Strâmbu, Daniel Alin Cristian, Ştefan Iulian Bedereag, Irina Alexandra Calangea, Elena Violeta Radu, IonuŢ Simion Coman, Vlad Andrei Porojan, Valentin Titus Grigorean
INTRODUCTION: Sacral tumors encompass numerous histopathological types. They represent an uncommon pathology and, when diagnosed, they are often in advanced stage of the disease, becoming a therapeutic challenge. The correct treatment of a sacral tumor should be established by a multidisciplinary team that will assess the exact anatomical, imagistic and histopathological characteristic of the tumors thus choosing an optimal surgical approach while taking into consideration the risk of recurrence...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28630074/the-enterohemorrhagic-escherichia-coli-effector-espw-triggers-actin-remodeling-in-a-rac1-dependent-manner
#16
Pamela Sandu, Valerie F Crepin, Hauke Drechsler, Andrew D McAinsh, Gad Frankel, Cedric N Berger
Enterohemorrhagic Escherichia coli (EHEC) is a diarrheagenic pathogen that colonizes the gut mucosa and induces attaching-and-effacing lesions. EHEC employs a type III secretion system (T3SS) to translocate 50 effector proteins that hijack and manipulate host cell signaling pathways, which allow bacterial colonization and subversion of immune responses and disease progression. The aim of this study was to characterize the T3SS effector EspW. We found espW in the sequenced O157:H7 and non-O157 EHEC strains as well as in Shigella boydii Furthermore, a truncated version of EspW, containing the first 206 residues, is present in EPEC strains belonging to serotype O55:H7...
September 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28528738/our-initial-experience-with-ventriculo-epiplooic-shunt-in-treatment-of-hydrocephalus-in-two-centers
#17
Valentin Titus Grigorean, Aurelia Mihaela Sandu, Mihai Popescu, Ioan Stefan Florian, Cristian Dumitru Lupascu, Corina Lupascu Ursulescu
INTRODUCTION: Hydrocephalus represents impairment in cerebrospinal fluid (CSF) dynamics. If the treatment of hydrocephalus is considered difficult, the repeated revisions of ventriculo-peritoneal (VP) shunts are even more challenging. OBJECTIVE: The aim of this article is to evaluate the efficiency of ventriculo-epiplooic (VEp) shunt as a feasible alternative in hydrocephalic patients. MATERIAL AND METHODS: A technical modification regarding the insertion of peritoneal catheter was imagined: midline laparotomy 8-10cm long was performed in order to open the peritoneal cavity; the great omentum was dissected between its two layers; we placed the distal end of the catheter between the two epiplooic layers; a fenestration of 4cm in diameter into the visceral layer was also performed...
July 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28523294/autophagy-in-aging-and-disease
#18
Mădălina Fîlfan, Raluca Elena Sandu, Alexandra Daniela Zăvăleanu, Andrei GreşiŢă, Daniela Gabriela Glăvan, Denissa Greta Olaru, Aurel Popa-Wagner
Autophagy is a catabolic degradation system used to destroy and recycle the unnecessary or damaged components of a cell. Autophagy is present at a basal level in all mammals and is regulated by some conditions, such as oxidative stress, starvation or hypoxia. In aged tissues, increased but also decreased expression of autophagy-specific proteins, Beclin 1, LC3, Atg5 and Atg7 has been reported. Likewise, it could be shown that the lifespan of yeast, nematodes and flies is prolonged by pharmacologically stimulated autophagy using exogenous administered spermidine...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28443268/complicated-postoperative-course-after-pulmonary-artery-sling-repair-and-slide-tracheoplasty
#19
Angelika Weber, Birgit Donner, Marie-Hélène Perez, Stefano Di Bernardo, Daniel Trachsel, Kishore Sandu, Nicole Sekarski
Pulmonary artery sling (PAS) is a rare congenital condition in which the left pulmonary artery (LPA) arises from the right pulmonary artery, and then passes between the trachea and the esophagus to reach the left lung, thereby forming a sling around the airway. It is often associated with intrinsic tracheal stenosis due to complete cartilaginous rings. Therapeutic management nowadays consists of one-stage reimplantation of the LPA and tracheoplasty with cardiopulmonary bypass support. Here, we present a 7-week-old boy with PAS and long-segment tracheal stenosis (LSTS) who underwent surgical intervention consisting of reimplantation of the LPA and slide tracheoplasty...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28413344/analytical-results-regarding-electrostatic-resonances-of-surface-phonon-plasmon-polaritons-separation-of-variables-with-a-twist
#20
R C Voicu, T Sandu
The boundary integral equation (BIE) method ascertains explicit relations between localized surface phonon and plasmon polariton resonances and the eigenvalues of its associated electrostatic operator. We show that group-theoretical analysis of the Laplace equation can be used to calculate the full set of eigenvalues and eigenfunctions of the electrostatic operator for shapes and shells described by separable coordinate systems. These results not only unify and generalize many existing studies, but also offer us the opportunity to expand the study of phenomena such as cloaking by anomalous localized resonance...
March 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
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